KR101724654B1 - Micro-needle patch and menufacturing method thereof - Google Patents

Abstract

The present invention can reduce the manufacturing cost by forming a gel film for supplying skin serum by electrospinning or electrospinning, and it is also possible to provide a micro-filter which can uniformly distribute drug or skin serum to the gel material for supplying the substance to be delivered, Needle patches and a method for manufacturing the same.
The microneedle patch of the present invention includes: a support having a groove formed therein; A plurality of micro needles protruding from a bottom surface of the groove; A gel membrane for supplying a substance to be transferred, which is composed of a mixture of a substance to be delivered and a biodegradable resin and filled in the groove in a gel state; And a protective film covering the gel membrane for supplying the transferred substance and adhered to the support.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a micro needle patch and a manufacturing method thereof,

The present invention relates to a microneedle patch, and more particularly, to a microneedle patch which can reduce a manufacturing cost by forming a gel film for supplying a substance to be delivered by electrospinning or electrospinning, To a microneedle patch which can smoothly permeate to the skin, and a manufacturing method thereof.

The micro needle patch is a kind of drug delivery system. It attaches the micro needle patch to the skin and injects the drug into the skin. This is a new concept drug injection technique with little pain.

Micro needle patches are used in medical and cosmetic applications by penetrating the stratum corneum of the epidermis and delivering the active ingredient into the skin.

Here, the microneedle is a fine needle that can create a passage directly through the epidermal layer and the dermal layer of the skin.

As described above, the micro needle patch has been variously applied to micro needle patches in the medical field in recent years, since the micro needle patch can administer the drug through the skin without pain unlike the conventional injection type, easy to use and simple operation.

Korean Patent Registration No. 10-1392947 discloses a polymer material which constitutes a common protrusion of micro protrusions and a common base portion of the micro protrusions, And microprojection massage patches comprising fibers of a linear structure of 0.1 mu m to 100 mu m in thickness dispersed in the polymer material. This massage patch has the advantage of being free from warping in the drying step during the manufacturing process, maintaining the flexibility, being free from the shape change that does not break even after being bent or bent, and has excellent air permeability.

However, in the massage patch disclosed in Korean Patent Registration No. 10-1392947, the microprojections that perforate the skin contain medicines, and these microprojections dissolve or melt and penetrate the skin to perform treatment and skin beauty Therefore, the amount of the pharmaceutical agent injected into the skin depends on the size of the microprojections, so that the amount of the pharmaceutical agent injected into the skin can not be increased and the manufacturing cost increases.

Accordingly, the present inventors have continued research on a technique capable of reducing the manufacturing cost of a micro needle patch, thereby forming a gel film for supplying a substance to be delivered into a thin film by electrospinning or electrospinning, The present invention has been completed and the present invention has been made more economical and feasible to compete with the present invention, by inventing and inventing structure and method features that can be applied to the inner skin region along the side wall of the skin to improve the effect of treatment and skin care.

Korean Patent Registration No. 10-1392947

SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned problems, and it is an object of the present invention to provide a drug delivery device for a drug delivery device, which comprises a micro needle for piercing a stratum corneum of a skin, And a microneedle patch that allows the same material to be permeated to penetrate into the skin along the outer surface of the microneedle, and a method of manufacturing the same.

Another object of the present invention is to provide a microneedle patch and a method of manufacturing the same that can form a gel film for supplying a substance to be delivered in an electrospinning or electrospray process, have.

In order to achieve the above-mentioned object, an embodiment of the present invention provides a semiconductor device comprising: a support having a groove formed therein; A plurality of micro needles protruding from a bottom surface of the groove; A gel membrane for supplying a substance to be transferred, which is composed of a mixture of a substance to be delivered and a biodegradable resin and filled in the groove in a gel state; And a protective film covering the gel membrane for supplying the transferred substance and adhered to the support section.

According to an embodiment of the present invention, there is provided a method of manufacturing a microfluidic device, comprising: preparing a support having a groove formed on one surface thereof and a plurality of micro needles protruding from the bottom surface of the groove; Mixing a substance to be delivered, a biodegradable resin and a solvent to prepare a spinning solution or a spraying solution; Electrostatically spinning the spinning solution or spraying the injection solution onto the groove of the support to form a gel film for supplying a transferring material; And adhering a protective film for protecting the gel membrane for supplying the transferred substance to the supporter.

As described above, in the present invention, the micro-holes formed on the skin by the microneedles are used to transfer substances to be delivered, such as drugs or skin serum, located on the outer surface of the microneedles to a predetermined region on the inner side of the skin along the outer surface of the microneedles By implementing a patch structure that can be injected, a larger amount of drug or skin serum can be injected into the skin area than a patch having the same size, and the effect of treatment and skin beauty can be improved.

In addition, in the present invention, a biodegradable resin mixed with a drug or a skin cosmetic and a solvent is filled in a groove of a support in the form of a thin film by electrospinning or electric spraying to form a gel film for supplying a substance to be transferred into a thin film, There is an advantage in that the manufacturing cost of the patch can be remarkably reduced.

In addition, in the present invention, a gel film for supplying a substance to be delivered, which can be injected into the skin, is formed by electrospinning or electrospinning so that the drug or skin serum is uniformly distributed in the gel film for supplying the substance to be delivered, Technology can be provided.

1 is a schematic cross-sectional view of a micro needle patch according to the present invention,
FIG. 2 is a schematic cross-sectional view illustrating a state in which a micro needle according to the present invention is infiltrated into the skin,
FIG. 3 is a schematic cross-sectional view illustrating a shape of a micro needle patch according to the present invention,
4 is a flowchart of a method of manufacturing a micro needle patch according to the present invention,
5A and 5B are schematic cross-sectional views illustrating a method of manufacturing a microneedle patch by electrospunning according to the present invention,
6 is a schematic cross-sectional view for explaining a method of manufacturing a microneedle patch by electric spraying according to the present invention,
7 is a schematic view of an electrospinning or electrospray device applied to the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

FIG. 1 is a schematic cross-sectional view of a microneedle patch according to the present invention, FIG. 2 is a schematic cross-sectional view schematically illustrating a state in which a microneedle according to the present invention penetrates the skin, Sectional view for explaining the shape of the light guide plate.

Referring to FIG. 1, a micro needle patch 200 according to the present invention includes a support 100 having a groove 110 formed therein; A plurality of micro needles 120 protruding from a bottom surface 111 of the groove 110; A gelatin (130) for supplying a substance to be transferred, which is formed in the groove (110) by being filled with a substance to be transferred and a biodegradable resin such as drug or skin serum by electrospinning or electrospinning; And a protective film 150 that covers the gel layer 130 for supplying the transferred substance and is bonded to the support portion 100.

The supporting part 100 has a groove 110 that can be filled with a nanofiber made of a drug or a skin cosmetic and a biodegradable resin or a droplet, and the groove 110 is electrospun or electrosprayed to form a drug or skin serum The biodegradable resin in which the substance to be delivered and the solvent are mixed is filled. The supporting part 100 has a dam on the outer circumferential part so that a groove 110 is formed therein.

At this time, since the micro needle patch of the present invention has a predetermined thickness after being attached to the skin, it protrudes from the skin. Preferably, the support portion 100 is formed in the form of a thin film because the protrusion degree should be good.

Here, the grooves 110 having a low depth can be formed by the support portion 100 in the form of a thin film, so that the filling capacity in the grooves 110 can be made small. Therefore, even if a small amount of medicines or skin cosmetic and biodegradable resins are injected into the grooves 110 of the support part 100, they can be filled in a full amount, thereby reducing manufacturing costs.

It is preferable that the support part 100 is made of a polymer material harmless to human body, and ULTEM among the polymer materials is preferably used. The supporting portion 100 may be formed by a plurality of microneedles 120 protruding at a predetermined interval from the bottom surface 111 of the groove 110 and the groove 110 by an injection molding process.

The mold for molding the supporting portion 100 can be precisely manufactured by a MEMS (Micro Electro Mechanical System).

The protective film 150 has a function of preventing gelation of the gelatinous membrane 130 for supplying a substance to be delivered and a function of blocking the penetration of foreign substances from the outside. The protective film 150 is formed of a gelatin 130 and is attached to the edge of the support portion 100.

An adhesive agent (not shown) is formed on the adhesion area where the protective film 150 and the support part 100 are bonded. In order to perform the micro needle patch 200, the protective film 150 is peeled off from the support part 100 The micro-needle patch 200 can be adhered to the skin because adhesive components remain in the adhesive region of the support portion 100 to which the protective film 150 is adhered.

The protective film 150 is provided for safely storing and transporting the microneedle patch 200, and performs a function similar to that of the release film.

When the user presses the supporting part 100 while peeling the protective film 150 from the supporting part 100 and bringing the gel membrane 130 for supplying the substance to be supplied into contact with the skin, the plurality of micro needles 120 punctures the skin And penetrate into the inside of the skin.

2, a hole 11 is formed in the skin 10 by the microneedle 120, and a gel-like medicament or skin serum existing on the side of the microneedle 120 is supplied to the microneedle 120. In this case, (10) along the outer surface of the skin (120) to receive treatment or skin care.

3, it is preferable that the width W1 of the upper region is narrower than the width W2 of the lower region with respect to the bottom surface 111 of the groove 110 for penetrating the skin . Here, the ends of the plurality of micro needles 120 may be sharp or rounded.

Therefore, the microneedle 130 can penetrate the stratum corneum of the skin, and the drug or skin serum can be injected into a predetermined region inside the skin along the outer surface of the micronee needle 120.

Since the hemorrhaging should not occur when a plurality of micro needles 120 penetrate the stratum corneum of the skin and drugs or skin serum are injected into a predetermined region on the inside of the skin, the height H of the plurality of micro needles 120 is preferably 1000 占 퐉 , And may be designed to be several micros to several hundreds of micros.

The plurality of micro needles 120 may be formed of a material capable of being biodegraded or dissolved by the body fluid in the skin so that the plurality of micro needles 120 penetrate into the inside of the skin to prevent side effects. Here, the biodegradation or dissolution of the plurality of micro needles 120 can be performed for a long time of a few hours in a short time of several seconds. In addition, the material of the plurality of micro needles 120 may be a harmless resin.

It is preferable that the support part 100 is integrally formed with a plurality of micro needles 120. In this case, the support part 100 in which the grooves 110 and the plurality of micro needles 120 are formed, Or may be formed of a material that can be biodegraded or dissolved by the reaction.

The materials that can be biodegraded or dissolved include polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), cellulose, hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC) Propyl methylcellulose (HPMC).

The gel membrane 130 for supplying a substance to be delivered is formed by a nanofiber or a droplet made of a biodegradable resin mixed with a drug or a skin serum and a solvent by electrospinning or electrospinning in the groove 110 of the supporter 100 And is kept in a gel state.

Herein, the solvent may be water-based, alcohol which is harmless to the human body, and an example of the biodegradable resin may be gelatin which is used as a medicine capsule in which collagen extracted from cartilage tissue of animals is processed.

In addition, the drug may be a single drug or a mixture of drugs, and may be in the form of an anesthetic, an anesthetic vaccine, an immunosuppressant, an immunogen, an immunomodulator, an immunoreactive agent, an immunostimulant, an analgesic, an antibiotic, a chitosan, collagen, A single drug of one of gelatin, hyaluronic acid, polylactic acid, and polyglycolic acid, or a mixed drug thereof. Thus, the drug can be diffused through the skin to the body tissue or the blood stream of the patient, so that the therapeutic effect can be given to the patient.

The skin serum is made up of cosmetic ingredients for skin care, such as, for example, essences.

Therefore, in the present invention, a patch structure that can inject drug or skin serum located on the outer surface of the micro needle into the dermal layer on the inner side of the skin along the outer surface of the micro needle with the hole formed in the skin by the micro needle, It is possible to inject a larger amount of drug or skin serum into the inner skin area than the patch of the same size, thereby improving the treatment and skin care efficiency.

5A and 5B are schematic sectional views for explaining a method of manufacturing a microneedle patch by electrospunning according to the present invention, and FIG. 6 is a cross- 1 is a schematic cross-sectional view for explaining a method of manufacturing a microneedle patch by electric spraying according to the present invention.

In the present invention, a micro needle patch is produced by electrospinning or electrospraying a biodegradable resin mixed with a drug or a skin serum and a solvent onto a support.

4, in order to manufacture a microneedle patch, a support having a plurality of micro needles protruding from the bottom surface of the groove is formed (S100), and then a drug or a drug The skin serum is mixed with a solvent and a biodegradable resin to prepare a spinning solution or a spraying solution (S110).

Thereafter, the spinning solution is electrospun or the injection solution is sprayed to the groove of the support to form a gel layer 130 for supplying a substance to be transferred (S120).

Subsequently, the gel film for supplying the substance to be delivered is wrapped with a protective film and adhered to the support (S130).

5A, when a spinning solution prepared by mixing a drug or skin serum and a solvent with a biodegradable resin is electrospun, the spinning nozzle 210 is used to spin the nanofibers 300, And is accumulated in the grooves 110 of the supporting part 100 to form the gel layer 130 for supplying the transferred substance to the nanofibers 300. [

When the nanofibers 300 are filled in the grooves 110 of the support part 100 and the formation of the gel layer 130 for supplying a substance to be transferred is completed, the electrospinning is terminated, The protective film 150 is adhered to the supporter 100 so as to surround the gel film 130 for supplying the substance to be delivered, as shown in FIG. 5B.

In addition, as shown in FIG. 6, in the step of performing the electric spraying, a spray solution made by mixing a drug or skin serum and a solvent with a biodegradable resin is sprayed from the spray nozzle 211. At this time, the droplets 310 are discharged from the injection nozzle 211, and the droplets 310 are accumulated in the grooves 110 of the supporter 100 to form the gel layer 130 for supplying a substance to be transferred.

As described above, in the present invention, by accumulating electrospun or electrospun nanofibers or droplets in the grooves 110 of the supporter 100 to form the gel membrane 130 for supplying the substance to be transferred, The micro needle patch has the following three structural features.

First, some of the plurality of microneedles 120 are completely surrounded by the gel layer 130 for supplying the substance to be transferred, and the rest of the plurality of microneedles 120 are not wrapped with the gel layer 130 , And the end thereof protrudes from the surface of the gel membrane 130 for supplying the substance to be delivered.

Secondly, all of the plurality of microneedles 120 are completely surrounded by the gel membrane 130 for supplying a substance to be transferred, so that a plurality of microneedles 120 can not be seen on the surface of the gel layer 130 for supplying a substance to be transferred Lt; / RTI >

Third, the ends of all of the plurality of microneedles 120 can not be wrapped by the gel layer 130 for supplying the transfer material, so that the ends of the plurality of microneedles 120 protrude from the surface of the gel layer 130 .

Accordingly, in the present invention, a gel film for supplying a substance to be transferred is filled by filling a biodegradable resin mixed with a drug or a skin cosmetic and a solvent in the grooves of the thin film support by electrospinning or electric spraying, It is possible to remarkably reduce the manufacturing cost of the semiconductor device.

In addition, in the present invention, a gel film for supplying a substance to be delivered, which can be injected into the skin, is formed by electrospinning or electrospinning so that the drug or skin serum is uniformly distributed in the gel film for supplying the substance to be delivered, will be.

7 is a schematic view of an electrospinning or electrospray device applied to the present invention.

7, the electrospinning or electrospray apparatus according to the present invention includes a solution tank 520 in which a drug solution or a skin cosmetic solution and a spinning solution obtained by mixing a solvent with a biodegradable resin are stored, a nozzle (not shown) connected to a high voltage generator (550).

The nozzles 550 are arranged on the upper side of the grounded collector 560 in the form of a conveyor moving at a constant speed and a plurality of nozzles 550 are arranged along the traveling direction (horizontal arrow direction) of the collector 560, The tank 520 may incorporate an agitator 530 using the mixing motor 510 as a driving source.

When the spinning solution or spraying solution sequentially discharged from the nozzle 550 is electrospun while passing through the nozzle 550 charged by the high voltage generator, the droplet is released (emitted in the direction of the vertical arrow) (Not shown) of the supporter 100 on the grounded collector 560 of a conveyor type moving at a constant speed to form a gel film for supplying a substance to be transferred in a gel state.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is clearly understood that the same is by way of illustration and example only and is not to be construed as limited to the embodiments set forth herein. Various changes and modifications may be made by those skilled in the art.

The present invention relates to a drug delivery system (DDS) and can be applied to a microneedle patch capable of effectively injecting a substance to be delivered, such as drug or skin serum, into the skin at low cost.

100: Support part 110: Home
111: bottom surface 120: micro needle
130: Gelatinized membrane for supplying transferring material 150: Protective film
200: Micro needle patch 210, 211, 550: Nozzle
300: nanofiber 310: droplet
510: mixing motor 520: solution tank
530: stirrer 560: collector

Claims (15)

A support having a groove formed therein;
A plurality of micro needles protruding from a bottom surface of the groove;
A gel membrane for supplying a substance to be transferred, which is composed of a mixture of a substance to be delivered and a biodegradable resin and filled in the groove in a gel state; And
And a protective film covering the gel membrane for supplying the substance to be transferred and adhered to the support,
Wherein the gel membrane for supplying a substance to be delivered is a gel formed by accumulating nanofibers or droplets made of a drug or a mixture of a skin serum and a biodegradable resin in the groove by electrospinning or electrospinning. delete delete delete The micro-needle according to claim 1, wherein the support portion is formed integrally with the plurality of micro needles,
The support is formed of a material that can be biodegraded or dissolved by bodily fluids. The method of claim 5, wherein the biodegradable or dissolvable material is selected from the group consisting of polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), cellulose, hydroxypropylcellulose (HPC) Micro needle patches, either cellulose (HEC) or hydroxypropyl methylcellulose (HPMC). The microneedle patch according to claim 1, wherein the microneedles have a width of an upper region narrower than a width of a lower region with respect to a bottom surface of the groove. The micro needle patch according to claim 1, wherein the microneedles are formed at a height capable of penetrating the stratum corneum of the skin, and the transferred material is injected into the skin along the outer surface of the microneedles. The micro needle patch according to claim 1, wherein the height of the micro needle is less than 1000 mu m. The method of claim 1, wherein the substance to be delivered comprises a drug,
The medicament may be an anesthetic, an anesthetic vaccine, an immunoadjuvant, an immunogen, an immunomodulator, an immunoreactive agent, an immunostimulant, an analgesic, an antibiotic, chitosan, collagen, gelatin, hyaluronic acid, A micro needle patch, which is a single drug of one of polylactic acid, polyglycolic acid, or a mixed drug thereof. The method according to claim 1, wherein the substance to be delivered comprises skin serum,
Wherein the skin serum is a cosmetic ingredient for skin care. The method according to claim 1, wherein a state in which a plurality of microneedles are protruded from a surface of the gel membrane for supplying a substance to be transferred, And the end of each of the plurality of micro needles protrudes from the surface of the gel layer for feeding the substance to be transferred, the gel film for feeding the substance to be transferred is filled in the groove. Preparing a support having a groove on one surface thereof and a plurality of micro-needles protruding from the bottom surface of the groove;
Mixing a substance to be delivered, a biodegradable resin and a solvent to prepare a spinning solution or a spraying solution;
The spinning solution is electrospun or the spraying solution is injected into the groove of the support to accumulate nanofibers or droplets mixed with the substance to be transferred and the biodegradable resin to form a gel film for supplying a substance to be transferred step; And
And adhering a protective film for protecting the gel membrane for supplying transferred materials to the support. 14. The method of claim 13, wherein the deliverable material comprises a drug or skin serum.





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