KR101752303B1 - Implantable biomaterial sensing device - Google Patents

Implantable biomaterial sensing device Download PDF

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KR101752303B1
KR101752303B1 KR1020160015044A KR20160015044A KR101752303B1 KR 101752303 B1 KR101752303 B1 KR 101752303B1 KR 1020160015044 A KR1020160015044 A KR 1020160015044A KR 20160015044 A KR20160015044 A KR 20160015044A KR 101752303 B1 KR101752303 B1 KR 101752303B1
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electrode
voltage
reference electrode
auxiliary electrode
impedance
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KR1020160015044A
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Korean (ko)
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윤치성
윤영준
이규인
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주식회사 에이엠피올
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/023—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance where the material is placed in the field of a coil
    • G01N27/025—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance where the material is placed in the field of a coil a current being generated within the material by induction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/028—Circuits therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements

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Abstract

The present invention relates to a body-insertable biosensor sensor, comprising: a first power supply unit for applying a predetermined direct-current voltage between a counter electrode and a reference electrode inserted into a body; A second power supply for applying a predetermined high frequency voltage between the auxiliary electrode and the reference electrode; And a controller for measuring a voltage between a working electrode inserted into the body and the auxiliary electrode when the set direct current voltage is applied between the auxiliary electrode and the reference electrode, And comparing the detected current with the data stored in the data storage unit to derive the biomaterial of the subject and if the set high frequency voltage is applied between the auxiliary electrode and the reference electrode, And a controller for detecting a current between the auxiliary electrode and the reference electrode by measuring a voltage between the working electrodes, and deriving an impedance from the detected current to detect an abnormality of the in-vivo biosensor measurement sensor.

Figure R1020160015044

Description

[0001] The present invention relates to an implantable biomaterial sensing device,

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a body-insertable biosensor sensor, and more particularly, to a body-insertable biosensor sensor capable of determining an abnormality of a sensor by applying a high-frequency voltage while a biosubstance is not measured.

Recently, the number of patients being treated with diabetes, one of the representative adult diseases, is continuously increasing. With this tendency, there is a rapid increase in interest and demand for blood glucose measuring devices, particularly, blood glucose measuring devices that are portable and easy to use in daily life, which are essential for the treatment of diabetes.

Conventionally, techniques for disposable blood glucose strip sensors have been developed as devices for measuring and managing blood glucose. However, in the case of the disposable blood glucose strip sensor, there is a disadvantage in that it is accompanied by pain or stress due to the need to directly collect blood using a needle or the like every time blood is collected. Recently, In fact.

An example of a technique for such a continuous measurement type blood glucose sensor is disclosed in Korean Patent Laid-Open Publication No. 10-2005-0055202, which discloses an implantable continuous measurement biosensor.

However, in the case of the continuous insertion type biosensor as described above, even if the electrode to which the voltage is applied is disconnected or short-circuited or the position of the sensor is changed, the current can be measured by the biomaterial bonded to the electrode. And the blood glucose measurement becomes unclear.

Korean Patent Publication No. 10-2005-0055202

An object of the present invention is to provide an in-vivo biosensor sensor capable of determining whether a sensor is abnormal by applying a high-frequency voltage while the biosensor is not being measured.

The present invention relates to a three-electrode type body-insertable biosensor sensor inserted into a body to measure a subject's biomaterial, wherein a set DC voltage is applied between a counter electrode inserted into the body and a reference electrode A first power supply unit for applying the first power supply voltage; A second power supply for applying a predetermined high frequency voltage between the auxiliary electrode and the reference electrode; And a controller for measuring a voltage between a working electrode inserted into the body and the auxiliary electrode when the set direct current voltage is applied between the auxiliary electrode and the reference electrode, And comparing the detected current with the data stored in the data storage unit to derive the biomaterial of the subject and if the set high frequency voltage is applied between the auxiliary electrode and the reference electrode, And a controller for measuring a voltage between the working electrodes to detect a current between the auxiliary electrode and the reference electrode and deriving an impedance from the detected current to detect an abnormality of the inserted biomolecule measurement sensor in the body, A material measurement sensor is provided.

The body-insertable biosensor sensor according to the present invention has the following effects.

First, by applying a high-frequency voltage between the auxiliary electrode and the reference electrode, the impedance between the auxiliary electrode and the reference electrode can be derived from the voltage difference measured between the auxiliary electrode and the working electrode, thereby determining whether the electrodes are disconnected, There is an effect that can be done.

Second, since a high frequency voltage is applied while the biomolecule is not measured, it is determined whether the sensor is abnormal, so that it is possible to grasp the abnormality of the sensor in real time.

FIG. 1 is a circuit diagram showing the structure of a body-insertable biosensor measuring sensor according to an embodiment of the present invention.

FIG. 1 is a perspective view of a body-insertable biosensor sensor according to the present invention.

In the body-insertable biosensor measuring sensor according to the present invention, the biosubstance is blood glucose. However, since the biomaterial is not limited to blood glucose, it is also possible to measure various biomaterials other than blood glucose.

First, a body-insertable biosensor measurement sensor 100 according to an embodiment of the present invention will be described with reference to FIG. 1, a body-insertable biosensor measuring sensor 100 according to an embodiment of the present invention includes a counter electrode (C), a working electrode (W), a reference electrode A first power source unit 110, a second power source unit 130, and a control unit 150. The first power source unit 110 includes a plurality of electrodes,

As described above, the body-insertable biosensor measurement sensor according to an embodiment of the present invention includes a three-electrode type implantable biomaterial measurement unit including the auxiliary electrode (C), the working electrode (W), and the reference electrode The auxiliary electrode C, the working electrode W and the reference electrode R are inserted into the body.

The auxiliary electrode C may be configured to apply a predetermined voltage to the working electrode W and the reference electrode R prior to a specific description of the in-vivo biomolecule measurement sensor 100 according to an embodiment of the present invention, Means an electrode in an electrochemical circuit for completing an electrochemical circuit. The reference electrode R means an electrode for providing a reference potential and the working electrode W means an electrode for measuring an amount of current generated by an oxidation-reduction reaction with an analyte by an applied voltage.

The first power supply unit 110 is configured to apply a predetermined direct current voltage between the auxiliary electrode C and the reference electrode R. In the present embodiment, the first power source unit 110 is applied as a DC direct current power source. Particularly, in this embodiment, the first power supply unit 110 applies a DC voltage of about 0.4 V between the auxiliary electrode C and the reference electrode R. FIG. However, since the voltage of 0.4 V is limited to the present embodiment, DC voltages of various sizes can be appropriately applied at a level that does not cause harm to the examinee.

The first power supply unit 110 applies a predetermined direct current voltage between the auxiliary electrode C and the reference electrode R in response to a command transmitted from the controller 150 to be described later. At this time, the first power supply unit 110 does not continuously apply the set direct current voltage between the auxiliary electrode C and the reference electrode R, but applies the predetermined direct current voltage to the auxiliary electrode C and the reference electrode R And a set direct current voltage is applied between the electrodes R. Therefore, as described later, the controller 150 is provided with a first timer 157 so that the first power supply unit 110 can transmit a command for applying a voltage at predetermined time intervals.

For example, if 5 minutes is input as the first predetermined time set in the first timer 157, the control unit 150 determines that the first power source unit 110 is at the first point in time, The first DC power supply 110 supplies the set DC voltage between the auxiliary electrode C and the reference electrode R at a time point 5 minutes after the reset, Quot; is repeated.

The second power supply 130 applies a predetermined high frequency voltage between the auxiliary electrode C and the reference electrode R. In the present embodiment, the second power source unit 130 is applied as a high frequency power source. In this embodiment, the second power supply unit 130 uses a high frequency of 100 Hz or more, and has a power of -10 dBm or less between the auxiliary electrode C and the reference electrode R in order to minimize the influence on the human body of the examinee The application of a high frequency voltage will be described as an example. Also, the second power supply 130 may apply a high-frequency voltage having a single frequency or a high-frequency voltage mixed with multiple frequencies.

The second power supply unit 130 applies a predetermined high frequency voltage between the auxiliary electrode C and the reference electrode R in response to a command transmitted from the controller 150 in the same manner as the first power supply unit 110. Unlike the first power supply unit 110, the second power supply unit 130 applies a set high-frequency voltage continuously or a set high-frequency voltage between the auxiliary electrode C and the reference electrode R at predetermined time intervals . However, if the set high-frequency voltage is continuously applied, the useful life of the inserted-type biomolecule measurement sensor 100 may be shortened.

Therefore, in order to increase the use efficiency of the insertion-type biomolecule measurement sensor 100, the controller 150 controls the first power supply unit 110 to supply the set DC voltage between the auxiliary electrode C and the reference electrode R, The second power supply unit 130 instructs the second power supply unit 130 to apply the set high frequency voltage between the auxiliary electrode C and the reference electrode R before or after the blood glucose level of the subject is applied.

Therefore, if the first DC power supply unit 110 applies the set DC voltage every 5 minutes, the blood glucose level of the subject is derived and the first timer 157 is reset while the first timer 157 is reset, And the second power supply unit 130 applies the high-frequency voltage.

1, the control unit 150 is connected to the first power supply unit 110 and transmits a command to apply the set direct current voltage to the first power supply unit 110. The second power supply unit 130, And transmits a command to apply the set high-frequency voltage to the second power supply unit 130. [ The control unit 150 is connected to the auxiliary electrode C and the working electrode W to measure a voltage between the auxiliary electrode C and the working electrode W to supply the auxiliary electrode C ) And the reference electrode (R) and derives the blood sugar of the subject from the detected current or derives the impedance to detect whether the electrodes are disconnected, short-circuited, or abnormality of the sensor.

The control unit 150 includes a voltage meter 151, a data storage unit 153, an alarm unit 155, and a first timer 157. The voltage meter 151 is connected to the auxiliary electrode C and the working electrode W to measure a voltage between the auxiliary electrode C and the working electrode W. In the present embodiment, the voltage meter 151 is illustratively applied as a potentiometer.

The current between the auxiliary electrode (C) and the reference electrode (W) is detected through the voltage between the auxiliary electrode (C) and the working electrode (W) measured as described above. The control unit 150 compares the detected current with the data stored in the data storage unit 153 to derive the blood glucose of the subject. When the current is detected through the above-described process, the data storage unit 153 extracts the blood glucose of the subject through comparison with the data storage unit 153, You can do it.

More specifically, the first power supply unit 110 to which the voltage application command is transmitted by the first timer 157 of the controller 150 is connected between the auxiliary electrode C and the reference electrode R The voltage measuring unit 151 connected to the auxiliary electrode C and the working electrode W measures the voltage between the auxiliary electrode C and the working electrode W. [

The controller 150 detects the current of the auxiliary electrode C and the reference electrode R with the voltage measured by the voltage meter 151. [ When the current is detected, the control unit 150 compares the detected current with the data stored in the data storage unit 153 to derive the blood glucose of the subject.

Meanwhile, when the control unit 150 receives the voltage command from the second power source unit 130 before deriving the blood sugar of the subject or derives the blood sugar of the subject by the procedure described above, When the voltage measuring unit 151 connected to the auxiliary electrode C and the working electrode W applies a predetermined high frequency voltage between the auxiliary electrode C and the reference electrode R, The voltage between the electrode (C) and the working electrode (W) is measured.

The control unit 150 controls the current flowing between the auxiliary electrode C and the reference electrode R by using the voltage between the auxiliary electrode C and the working electrode W measured by the voltage meter 151, And derives an impedance using the detected current and the set high-frequency voltage. The controller 150 determines that the inserted biomaterial measurement sensor 100 is normal when the derived impedance is within a set maximum impedance and a set maximum impedance range.

However, when the derived impedance is out of the set minimum impedance and the set maximum impedance range, it is determined that the electrodes are disconnected or short-circuited, or that there is an abnormality in the internal body type biomolecule measurement sensor 100, Let it ring.

Since the high frequency voltage has a waveform shape, reactance occurs in the impedance. Therefore, it is possible to detect whether the electrodes are disconnected or short-circuited by setting the set minimum impedance and the set maximum impedance range as described above. That is, if the derived impedance is in the range below the set minimum impedance, it is possible to sense that the electrodes are short-circuited. If the derived impedance is within the set maximum impedance, it can be detected that the electrodes are disconnected.

Meanwhile, although not shown in the figure, the controller 150 may further include a transmitter (not shown). The transmitter (not shown) transmits the blood sugar derived from an output unit (not shown) provided separately to the outside so that the blood sugar can be determined by the subject when the blood glucose is derived as described above.

While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims. Accordingly, the true scope of the present invention should be determined by the technical idea of the appended claims.

100: In-body biomaterial sensor
110: first power supply unit 130: second power supply unit
150: controller 151: voltage meter
153: Data storage unit
155: alarm unit 157: first timer

Claims (6)

A three-electrode type implantable biosensor sensor inserted into a body to measure a biomaterial of a subject,
A first power supply unit for applying a predetermined direct current voltage between a counter electrode and a reference electrode inserted in the body;
A second power supply for applying a predetermined high frequency voltage between the auxiliary electrode and the reference electrode;
And a control unit for deriving the biomaterial of the subject or detecting an abnormality of the biomaterial measurement sensor in the body,
Wherein the controller transmits a command to apply the set high-frequency voltage to the second power supply unit before deriving the biomaterial of the subject,
When the set high frequency voltage is applied between the auxiliary electrode and the reference electrode, the voltage between the working electrode inserted into the body and the auxiliary electrode is measured to detect the current between the auxiliary electrode and the reference electrode And derives an impedance from the detected current,
The reference electrode, the working electrode, and the working electrode, if the derived impedance is within the set minimum impedance and the set maximum impedance range, if the impedance is less than the set minimum impedance, It is determined that the reference electrode and the working electrode are disconnected when the maximum impedance is greater than the set maximum impedance,
The set direct current voltage is applied between the auxiliary electrode and the reference electrode to measure the voltage between the working electrode and the auxiliary electrode only when the biosensor measurement sensor is determined to be normal, And detects the current and compares the detected current with the data stored in the data storage unit to derive the biomaterial of the subject. The method according to claim 1,
Wherein,
And an alarm unit for determining that there is an abnormality in the internal body type biosensor measurement sensor and for alarming the internal body type biosensor measurement sensor. The method according to claim 1,
Wherein,
Further comprising: a first timer for transmitting an instruction to apply said set direct current voltage by said first power source unit at a first set time. delete The method according to claim 1,
Wherein the set high-frequency voltage is 100 Hz or more, and a high-frequency voltage having a power of -10 dBm or less is applied. The method according to claim 1,
Wherein the set high-frequency voltage is a voltage of a single frequency or a mixed voltage of multiple frequencies.
KR1020160015044A 2016-02-05 2016-02-05 Implantable biomaterial sensing device KR101752303B1 (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011053232A (en) * 2004-06-18 2011-03-17 F Hoffmann-La Roche Ag System and method for quality assurance of biosensor test strip
JP2015200672A (en) * 2012-04-19 2015-11-12 パナソニックヘルスケアホールディングス株式会社 Biological information measurement device and biological information measurement method using the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011053232A (en) * 2004-06-18 2011-03-17 F Hoffmann-La Roche Ag System and method for quality assurance of biosensor test strip
JP2015200672A (en) * 2012-04-19 2015-11-12 パナソニックヘルスケアホールディングス株式会社 Biological information measurement device and biological information measurement method using the same

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