KR101751809B1 - Biomaterial sensing device and sensing method of biomaterial - Google Patents

Biomaterial sensing device and sensing method of biomaterial Download PDF

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KR101751809B1
KR101751809B1 KR1020160015041A KR20160015041A KR101751809B1 KR 101751809 B1 KR101751809 B1 KR 101751809B1 KR 1020160015041 A KR1020160015041 A KR 1020160015041A KR 20160015041 A KR20160015041 A KR 20160015041A KR 101751809 B1 KR101751809 B1 KR 101751809B1
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electrode
auxiliary electrode
impedance
reference electrode
voltage
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KR1020160015041A
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윤치성
윤영준
이규인
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주식회사 에이엠피올
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/028—Circuits therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers

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Abstract

The present invention relates to a biosensor measuring sensor, comprising: a first power supply unit for applying a predetermined direct current voltage between a counter electrode and a reference electrode; A second power supply for applying a predetermined high frequency voltage between the auxiliary electrode and the reference electrode; And a controller for deriving the biomaterial, wherein the controller measures a voltage between a working electrode and the auxiliary electrode when the set direct current voltage is applied between the auxiliary electrode and the reference electrode, Wherein a voltage between the working electrode and the auxiliary electrode is measured to detect a first current value between the auxiliary electrode and the reference electrode and when the set high frequency voltage is applied between the auxiliary electrode and the reference electrode, Detecting an impedance between the auxiliary electrode and the reference electrode from the set high frequency voltage and the detected second current value after detecting a second current value between the reference electrode and the first current value, Thereby deriving the biomaterial.

Figure R1020160015041

Description

TECHNICAL FIELD [0001] The present invention relates to a biomaterial sensing device and a biomaterial sensing method,

The present invention relates to a biosensor, and more particularly, to a biosensor sensor capable of accurately measuring the biosensor by improving its sensitivity by correcting itself even if the electrode deteriorates due to the adsorption of foreign matter during long- To a measurement sensor.

Recently, the number of patients being treated with diabetes, one of the representative adult diseases, is continuously increasing. With this tendency, there is a rapid increase in interest and demand for blood glucose measuring devices, particularly, blood glucose measuring devices that are portable and easy to use in daily life, which are essential for the treatment of diabetes.

Conventionally, techniques for disposable blood glucose strip sensors have been developed as devices for measuring and managing blood glucose. However, in the case of the disposable blood glucose strip sensor, there is a disadvantage in that it is accompanied by pain or stress due to the need to directly collect blood using a needle or the like every time blood is collected. Recently, In fact.

An example of a technique for such a continuous measurement type blood glucose sensor is disclosed in Korean Patent Laid-Open Publication No. 10-2005-0055202, which discloses an implantable continuous measurement biosensor.

However, when the continuous insertion type biosensor as described above is used for a long time, foreign substances such as proteins are adsorbed on the electrodes and deteriorated, resulting in a problem that the measurement sensitivity of the electrodes is deteriorated. In particular, the degree of deterioration of the electrode can not be easily confirmed by the naked eye of the subject, and the subject must be relied on even if the measurement result is not accurate. Conventionally, in order to solve such a problem, the blood was sampled several times at a predetermined time, the blood glucose value read as blood glucose was used as a standard, the value was input to the continuous insertion biosensor in the body, and then the blood glucose value was compared with the output signal. However, this calibration method also has a problem in that the measurement efficiency of the blood glucose is decreased.

Korean Patent Publication No. 10-2005-0055202

An object of the present invention is to provide a biosensor measuring sensor that can accurately measure biomaterial by improving the measurement sensitivity by correcting itself even if the electrode deteriorates due to the adsorption of foreign matter during long-term use and the measurement sensitivity is lowered.

The present invention relates to a three-electrode type biosubstance measurement sensor capable of measuring a biomaterial of a subject, comprising: a first power source unit for applying a predetermined direct current voltage between a counter electrode and a reference electrode; A second power supply for applying a predetermined high frequency voltage between the auxiliary electrode and the reference electrode; And a controller for deriving the biomaterial, wherein the controller measures a voltage between a working electrode and the auxiliary electrode when the set direct current voltage is applied between the auxiliary electrode and the reference electrode, Wherein a voltage between the working electrode and the auxiliary electrode is measured to detect a first current value between the auxiliary electrode and the reference electrode and when the set high frequency voltage is applied between the auxiliary electrode and the reference electrode, Detecting an impedance between the auxiliary electrode and the reference electrode from the set high frequency voltage and the detected second current value after detecting a second current value between the reference electrode and the first current value, And a biomolecule measurement sensor for deriving the biomaterial based thereon.

The biosensor measuring sensor according to the present invention has the following effects.

First, the impedance can be detected by applying a high-frequency voltage between the auxiliary electrode and the reference electrode. Thus, the degree of deterioration of the electrodes can be grasped through the detected impedance, and the impedance variation between the auxiliary electrode and the reference electrode can be measured So that accurate measurement results of the biomaterial can be obtained.

Second, since the high frequency voltage is applied separately from the DC voltage applied between the auxiliary electrode and the reference electrode, the degree of deterioration of the electrode can be grasped in real time through the impedance detected by the application of the high frequency voltage, Lt; / RTI >

1 is a circuit diagram showing a structure of a biosensor measurement sensor according to an embodiment of the present invention.
FIG. 2 is a view showing a biomaterial measurement method using the biosensor measurement sensor according to FIG.

1 and 2 show a biosensor measurement sensor according to the present invention.

The biosubstance measurement sensor according to the present invention can measure the biosubstance by inserting the biosubstance into the body or can measure the biosubstance without insertion into the body. In the embodiment of the present invention, the biosensor is inserted into the body to measure the biosubstance, and the biosubstance is blood sugar. However, since the biomaterial is not limited to blood glucose, it is also possible to measure various biomaterials other than blood glucose.

First, a biosensor measurement sensor 100 according to an embodiment of the present invention will be described with reference to FIG. 1, a biosensor measurement sensor 100 according to an embodiment of the present invention includes a counter electrode (C '), a working electrode (W'), a reference electrode A first power source unit 110, a second power source unit 130, and a control unit 150. The first power source unit 110 includes a plurality of reference electrons (hereinafter, referred to as 'R').

As described above, the biosensor measurement sensor according to an embodiment of the present invention is a three-electrode type biosensor measurement sensor 100 comprising an auxiliary electrode C, the working electrode W, and the reference electrode R The auxiliary electrode C, the working electrode W, and the reference electrode R are inserted into the body.

Before describing the biosensor measurement sensor 100 according to an embodiment of the present invention, the above-described electrodes will be concretely described. The auxiliary electrode C means a working electrode W and a reference electrode R Means an electrode in an electrochemical circuit that functions to allow a constant voltage to be applied to complete an electrochemical circuit. The reference electrode R means an electrode for providing a reference potential and the working electrode W means an electrode for measuring an amount of current generated by an oxidation-reduction reaction with an analyte by an applied voltage.

The first power supply unit 110 is configured to apply a predetermined direct current voltage between the auxiliary electrode C and the reference electrode R. In the present embodiment, the first power source unit 110 is applied as a DC direct current power source. Particularly, in this embodiment, the first power supply unit 110 applies a DC voltage of about 0.4 V between the auxiliary electrode C and the reference electrode R. FIG. However, since the voltage of 0.4 V is limited to the present embodiment, DC voltages of various sizes can be appropriately applied at a level that does not cause harm to the examinee.

The first power supply unit 110 applies a predetermined direct current voltage between the auxiliary electrode C and the reference electrode R in response to a command transmitted from the controller 150 to be described later. At this time, the first power supply unit 110 does not continuously apply the set direct current voltage between the auxiliary electrode C and the reference electrode R, but applies the predetermined direct current voltage to the auxiliary electrode C and the reference electrode R And a set direct current voltage is applied between the electrodes R. Therefore, as described later, the controller 150 is provided with a first timer 157 so that the first power supply unit 110 can transmit a command for applying a voltage at predetermined time intervals.

For example, if 5 minutes is input as the first predetermined time set in the first timer 157, the controller 150 determines that the first power source 110 is turned on at the latest time, The first power supply unit 110 may supply a predetermined DC voltage between the auxiliary electrode C and the reference electrode R at a time point of 5 minutes after the reset, A command to apply the set DC voltage is repeated.

The second power supply 130 applies a predetermined high frequency voltage between the auxiliary electrode C and the reference electrode R. In the present embodiment, the second power source unit 130 is applied as a high frequency power source. In this embodiment, the second power supply unit 130 uses a high frequency of 100 Hz or more, and has a power of -10 dBm or less between the auxiliary electrode C and the reference electrode R in order to minimize the influence on the human body of the examinee The application of a high frequency voltage will be described as an example. Also, the second power supply 130 may apply a high-frequency voltage having a single frequency or a high-frequency voltage mixed with multiple frequencies.

The second power supply unit 130 applies a predetermined high frequency voltage between the auxiliary electrode C and the reference electrode R in response to a command transmitted from the controller 150 in the same manner as the first power supply unit 110. The control unit 150 may be configured to measure the first current value between the auxiliary electrode C and the reference electrode R by applying the set direct current voltage by the first power source unit 110, And instructs the second power supply unit 130 to apply the set high-frequency voltage.

In this embodiment, as described above, if the first DC power supply 110 applies the set DC voltage every 5 minutes, the first current value between the auxiliary electrode C and the reference electrode R And the second power supply unit 130 applies the high-frequency voltage.

1, the control unit 150 is connected to the first power supply unit 110 and transmits a command to apply the set direct current voltage to the first power supply unit 110. The second power supply unit 130, And transmits a command to apply the set high-frequency voltage to the second power supply unit 130. [ The control unit 150 is connected to the auxiliary electrode C and the working electrode W to measure a voltage between the auxiliary electrode C and the working electrode W to generate the auxiliary electrode C ) And the reference electrode (R).

In particular, the impedance between the auxiliary electrode (C) and the reference electrode (R) is derived through the second current value, and the derived impedance is compared with the set impedance to derive the blood glucose based on the first current value Or derives blood glucose based on the first current value and an impedance change amount between the auxiliary electrode (C) and the reference electrode (R).

The controller 150 includes a voltage measurer 151, a transmitter 155, and a first timer 157. The controller 150 may be a microprocessor, The voltage measuring device 151 is connected to the auxiliary electrode C and the working electrode W and is connected to the auxiliary electrode C when applying the set direct current voltage between the auxiliary electrode C and the reference electrode R. [ The auxiliary electrode C and the working electrode W are connected to each other by measuring a voltage between the auxiliary electrode C and the working electrode W or by applying the set high frequency voltage between the auxiliary electrode C and the reference electrode R, Is measured. In the present embodiment, the voltage meter 151 is illustratively applied as a potentiometer.

The control unit 150 may measure the voltage between the auxiliary electrode C and the working electrode W by the voltage measuring unit 151 so that the auxiliary electrode C and the reference electrode And the voltage between the auxiliary electrode (C) and the working electrode (W) is measured by the voltage meter (151) when the set high frequency voltage is applied to the auxiliary electrode (C ) And the reference electrode (R). The impedance between the auxiliary electrode (C) and the reference electrode (R) is detected through the second current value, and the impedance between the auxiliary electrode (C) and the reference electrode Can be derived.

The voltage between the auxiliary electrode C and the working electrode W is measured through the voltage measuring device 151 and the voltage of the auxiliary electrode C is measured by the second power source 130, C and the reference electrode R, the impedance between the auxiliary electrode C and the reference electrode R is detected from the second current value. The impedance thus detected is compared with the pre-stored set impedance, wherein the pre-stored set impedance means the initial impedance detected by the biosubstance electrode sensor 100.

When the detected impedance is equal to the set impedance, it is determined that the electrodes are not deteriorated. If the detected impedance is different from the set impedance, it is determined that the electrodes are deteriorated. When the detected impedance is different from the set impedance, the blood glucose is derived based on the impedance change amount between the auxiliary electrode (C) and the reference electrode (R) and the first current value.

<Function formula 1>

Biomaterial = f (first current value)

Conventionally, blood glucose has been derived using the above-described <Function Formula 1>. However, as shown in the above-mentioned <Function Formula 1>, blood glucose has been derived without taking impedance into consideration. none.

<Function formula 2>

Biomaterial = g 1 (first current value, impedance)

<Function formula 3>

Biomaterial = g 2 (first current value, impedance change amount)

However, in this embodiment, blood glucose is derived using the above-described <Function 2> or <Function 3>. As shown in the above function, since blood glucose is derived by taking impedance into account, accurate blood glucose can be derived have. That is, if the detected impedance is equal to the set impedance as described above, blood glucose can be derived using the above-described < Function 2 >. If the detected impedance is different from the set impedance, Can be used to derive blood glucose.

The transmitter 155 transmits the blood glucose derived as described above to an output unit (not shown) separately provided to the subject so that the subject can check the blood glucose. The output unit (not shown) may be applied as a display, but the present invention is not limited thereto.

As described above, the first timer 157 is configured to transmit a command to the controller 150 to apply the voltage by the first power unit 110 at the first set time.

FIG. 2 shows a method of measuring blood glucose using the biosensor measurement sensor 100 having the above-described configuration.

Referring to FIG. 2, the first timer 157 of the controller 150 controls the first power supply unit 110 to supply the auxiliary electrode C, The set direct current voltage is applied between the reference positive polarity R (step S205)

When the set DC voltage is applied between the auxiliary electrode C and the reference electrode R by the first power supply unit 110, the controller 150 controls the auxiliary electrode C and the reference electrode R, (Step S210)

More specifically, the voltage measuring device 151 of the control unit 150 connected to the auxiliary electrode C and the working electrode W detects a voltage between the auxiliary electrode C and the working electrode W And a first current value between the auxiliary electrode (C) and the reference electrode (R) is detected therefrom.

After the first current value between the auxiliary electrode C and the reference electrode R is detected as described above, the controller 150 controls the second power source 130 to supply the auxiliary electrode C ) And the reference positive electrode R (step S215).

When the set high frequency voltage is applied between the auxiliary electrode C and the reference electrode R by the second power supply unit 130, the controller 150 controls the auxiliary electrode C and the reference positive electrode R (Step &lt; RTI ID = 0.0 &gt; S220). &Lt; / RTI &

More specifically, the voltage measuring device 151 of the controller 150 measures the voltage between the auxiliary electrode C and the working electrode W, and from the auxiliary electrode C to the working electrode W, And a second current value between the electrodes R is detected. The controller 150 detects an impedance between the auxiliary electrode C and the reference electrode R from the detected second current value.

Then, the blood glucose level of the examinee is derived by reflecting the detected impedance and the first current value (step S225)

The detected impedance is compared with the preset impedance stored in the controller 150, that is, the initial impedance. At this time, if the detected impedance is equal to the set impedance, the controller 150 determines that the auxiliary electrode C, the working electrode W, and the reference electrode R are not deteriorated, The blood glucose is derived based on the first current value and the detected impedance using the function formula 2.

However, if the detected impedance and the set impedance are not equal to each other, the controller 150 determines that the auxiliary electrode C, the working electrode W, and the reference electrode R are deteriorated, The blood glucose is derived based on the first current value and the impedance change amount between the auxiliary electrode (C) and the reference electrode (R) using the function formula (3).

Finally, the transmitter 155 of the controller 150 transmits the derived blood glucose to the output unit (not shown) separately provided to the outside, and transmits the blood glucose to the subject through the output unit (not shown) You can check your blood sugar.

In the present embodiment, the current between the auxiliary electrode C and the reference electrode R is detected first, and the impedance between the auxiliary electrode C and the reference electrode R is detected. , But the present invention is not limited thereto. That is, the impedance between the auxiliary electrode (C) and the reference electrode (R) is detected first without detecting the first current value between the auxiliary electrode (C) and the reference electrode (R) The degree of change may be determined first, and the first current value between the auxiliary electrode C and the reference electrode R may be measured to derive blood glucose.

The biosensor measurement sensor according to an embodiment of the present invention can detect foreign substances such as proteins due to the foreign substances such as proteins adsorbed on the electrodes of the biosubstance measurement sensor due to long time use, Since the correction of the current can be made, it is possible to accurately measure the biomaterial even if it is used for a long time.

While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims. Accordingly, the true scope of the present invention should be determined by the technical idea of the appended claims.

100: Biomaterial measuring sensor
110: first power supply unit 130: second power supply unit
150: controller 151: voltage meter
155: transmitting unit 157: first timer

Claims (8)

A three-electrode type biological material measurement sensor capable of measuring a biomaterial of a subject,
A first power supply unit for applying a predetermined direct current voltage between a counter electrode and a reference electrode inserted in the body;
A second power source for applying a high frequency voltage of 100 Hz or more between the auxiliary electrode and the reference electrode and having a power of -10 dBm or less; And
A voltage between the working electrode inserted into the body and the auxiliary electrode is measured to determine a first current value between the auxiliary electrode and the reference electrode, / RTI &gt;
A second current value between the auxiliary electrode and the reference electrode is measured by measuring a voltage between the working electrode and the auxiliary electrode when the high frequency voltage is applied between the auxiliary electrode and the reference electrode,
Detecting an impedance between the auxiliary electrode and the reference electrode from the second current value, comparing the detected impedance with a pre-stored set impedance to determine whether the auxiliary electrode and the reference electrode are deteriorated,
If it is determined that the auxiliary electrode and the reference electrode are not deteriorated, deriving the biomaterial using the following Equation 1 based on the first current value and the impedance,
Determining whether the auxiliary electrode and the reference electrode are deteriorated, determining an impedance change amount between the auxiliary electrode and the reference electrode, determining the impedance change amount based on the first current value and the impedance change amount, And a controller for deriving the biomaterial.
<Function formula 1>
Biomaterial = g 1 (the first current value, the impedance)
<Function formula 2>
Biomaterial = g 2 (the first current value, the impedance change amount)

(Wherein g 1 and g 2 is a function) The method according to claim 1,
Wherein the control unit includes a transmitter for transmitting the biomaterial to an output unit separately provided to the subject so that the subject can confirm the biomaterial. The method according to claim 1,
Wherein,
And the impedance is measured by the high-frequency voltage before or after the measurement of the first current value by the DC voltage. The method according to claim 1,
Wherein the set high-frequency voltage is applied with a voltage of a single frequency or a mixed frequency. The method according to claim 1,
Wherein the biomaterial is blood sugar. A method for measuring a biological material by a three-electrode type biological material measurement sensor capable of measuring a biological material of a subject,
Applying a predetermined direct current voltage between a counter electrode and a reference electrode by a first power supply unit;
Applying a high frequency voltage having a power of not more than -10 dBm to the second power supply unit between the auxiliary electrode and the reference electrode by 100 Hz or more;
When the set direct current voltage is applied between the auxiliary electrode and the reference electrode, the control unit measures the voltage between the working electrode and the auxiliary electrode to detect the first current value between the auxiliary electrode and the reference electrode ;
Detecting a second current value between the auxiliary electrode and the reference electrode by measuring a voltage between the working electrode and the auxiliary electrode when the high frequency voltage is applied between the auxiliary electrode and the reference electrode;
The control unit detects an impedance from the second current value and compares the impedance with a pre-stored set impedance to determine whether the auxiliary electrode and the reference electrode are deteriorated; And
Wherein the controller determines whether the auxiliary electrode and the reference electrode are deteriorated or not,
In the step of determining whether or not the deterioration occurs,
If it is determined that the auxiliary electrode and the reference electrode are not deteriorated, deriving the biomaterial using the following Equation 1 based on the first current value and the impedance,
In the step of determining whether or not the deterioration occurs,
Determining an amount of change in impedance between the auxiliary electrode and the reference electrode when it is determined that the auxiliary electrode and the reference electrode have deteriorated; and determining, based on the first current value and the impedance change amount, And the biomaterial is derived from the biomaterial.

<Function formula 1>
Biomaterial = g 1 (the first current value, the impedance)
<Function formula 2>
Biomaterial = g 2 (the first current value, the impedance change amount)

(Wherein g 1 and g 2 is a function) delete delete
KR1020160015041A 2016-02-05 2016-02-05 Biomaterial sensing device and sensing method of biomaterial KR101751809B1 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190061674A (en) 2017-11-28 2019-06-05 주식회사 엘지화학 Vapor deposition apparatus and deposition method using the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011053232A (en) * 2004-06-18 2011-03-17 F Hoffmann-La Roche Ag System and method for quality assurance of biosensor test strip

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011053232A (en) * 2004-06-18 2011-03-17 F Hoffmann-La Roche Ag System and method for quality assurance of biosensor test strip

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190061674A (en) 2017-11-28 2019-06-05 주식회사 엘지화학 Vapor deposition apparatus and deposition method using the same

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