KR100479018B1 - A process for producing a high L-carnitine-containing egg - Google Patents
A process for producing a high L-carnitine-containing egg Download PDFInfo
- Publication number
- KR100479018B1 KR100479018B1 KR10-1998-0056982A KR19980056982A KR100479018B1 KR 100479018 B1 KR100479018 B1 KR 100479018B1 KR 19980056982 A KR19980056982 A KR 19980056982A KR 100479018 B1 KR100479018 B1 KR 100479018B1
- Authority
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- South Korea
- Prior art keywords
- carnitine
- feed
- meal
- eggs
- feeding
- Prior art date
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- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title claims abstract description 52
- 238000000034 method Methods 0.000 title claims description 10
- 235000012054 meals Nutrition 0.000 claims abstract description 10
- 239000010977 jade Substances 0.000 claims abstract description 6
- 235000019733 Fish meal Nutrition 0.000 claims abstract description 5
- 108010068370 Glutens Proteins 0.000 claims abstract description 5
- 235000019779 Rapeseed Meal Nutrition 0.000 claims abstract description 5
- 235000019764 Soybean Meal Nutrition 0.000 claims abstract description 5
- 240000008042 Zea mays Species 0.000 claims abstract description 5
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims abstract description 5
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims abstract description 5
- 235000005822 corn Nutrition 0.000 claims abstract description 5
- 235000012343 cottonseed oil Nutrition 0.000 claims abstract description 5
- 239000004467 fishmeal Substances 0.000 claims abstract description 5
- 235000021312 gluten Nutrition 0.000 claims abstract description 5
- 239000004456 rapeseed meal Substances 0.000 claims abstract description 5
- 239000004455 soybean meal Substances 0.000 claims abstract description 5
- 239000003760 tallow Substances 0.000 claims abstract description 5
- 238000000855 fermentation Methods 0.000 claims abstract description 4
- 230000004151 fermentation Effects 0.000 claims abstract description 4
- 244000005700 microbiome Species 0.000 claims abstract description 4
- 235000013601 eggs Nutrition 0.000 abstract description 28
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 210000002969 egg yolk Anatomy 0.000 description 11
- 235000013345 egg yolk Nutrition 0.000 description 9
- 102000002322 Egg Proteins Human genes 0.000 description 8
- 108010000912 Egg Proteins Proteins 0.000 description 8
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 6
- 235000004347 Perilla Nutrition 0.000 description 5
- 241000229722 Perilla <angiosperm> Species 0.000 description 5
- 235000016709 nutrition Nutrition 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 229940012843 omega-3 fatty acid Drugs 0.000 description 3
- 239000006014 omega-3 oil Substances 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000007704 transition Effects 0.000 description 3
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 239000003674 animal food additive Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 150000004668 long chain fatty acids Chemical class 0.000 description 2
- 210000004165 myocardium Anatomy 0.000 description 2
- 229910052711 selenium Inorganic materials 0.000 description 2
- 239000011669 selenium Substances 0.000 description 2
- 235000011649 selenium Nutrition 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 208000010496 Heart Arrest Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- 210000004413 cardiac myocyte Anatomy 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 238000010668 complexation reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- -1 iron ions Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000020665 omega-6 fatty acid Nutrition 0.000 description 1
- 229940033080 omega-6 fatty acid Drugs 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 238000009374 poultry farming Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229940091258 selenium supplement Drugs 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 235000021195 test diet Nutrition 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L15/00—Egg products; Preparation or treatment thereof
- A23L15/25—Addition or treatment with microorganisms or enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/06—Amino acid
- A23V2250/0612—Carnitine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Birds (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Abstract
본 발명은 옥수수, 대두박, 채종박, 면실박, 옥글루텐, 옥배아박, 어분 및 우지로 이루어진 기초사료에 미생물의 발효에 의해 생산된 활성형 L-카르니틴 30ppm 이상, 바람직하게는 50ppm 이상, 더욱 바람직하게는 100ppm 이상을 첨가하고 이 사료를 산란계에 1주 이상 급여함을 특징으로 하는 L-카르니틴 고함량 계란의 제조방법을 제공한다.The present invention is at least 30ppm, preferably at least 50ppm, of active L-carnitine produced by fermentation of microorganisms in a basic feed consisting of corn, soybean meal, rapeseed meal, cottonseed meal, ox gluten, jade germ meal, fish meal and tallow. Preferably, at least 100 ppm is added, and the feed is provided for the production of L-carnitine high content eggs, characterized in that the feeding of at least one week to laying hens.
Description
본 발명은 양계산업에 관한 것으로서, 보다 상세하게는 L-카르니틴(L-Carnitine)이 계란내로 효율적으로 이행되도록 L-카르니틴을 적당량 함유한 사료를 일정기간 산란계에 급여함으로써 고함량의 L-카르니틴이 함유된 계란을 제조하는 방법에 관한 것이다.The present invention relates to the poultry industry, and more specifically, L-carnitine by feeding a suitable amount of L-carnitine to a laying hen for a certain period so that L-carnitine is efficiently transferred into eggs. The present invention relates to a method for preparing the contained eggs.
최근에 계란의 부가가치를 향상시키기 위한 목적으로 일부 비타민 및 지방산을 사료에 강화시켜 계란내로의 이행을 증가시키기 위한 시도가 다양하게 이루어져 왔다. 한국특허 제87081호는 소화가 잘되며 섭취시에 정상적인 성장이나 건강을 향상시켜 주는 동시에 질병 예방을 할 수 있는 다량의 비타민 A와 셀레늄 및 비타민 E를 함유하는 특수란 제조용 사료 조성물에 관한 것으로 사료 1kg당 비타민 A 30,000IU, 셀레늄 1.16mg 내지 8.16mg, 비타민 E 30mg 내지 5mg을 첨가하여 이 사료를 산란중인 산란계에 투여하여 계란을 제조하는 방법을 기술하고 있다. 한국특허공고 제92-7672호는 사료를 가축에 급여하여서 생산되는 고기내 오메가 지방산의 함량을 높이고 콜레스테롤 함량을 낮추게 하는 지방 사료 첨가제를 기술하고 있다. 한국특허공고 제93-11396호는 EPA + DHA 강화 첨가제를 함유한 산란계 배합 사료와 이 사료를 효과적으로 급여함으로써 생리적으로 유효한 EPA + DHA가 계란의 난황에 함유하도록 하는 계란의 제조방법을 교시한다. 한국특허공고 제95-13949호는 곡류를 위주로 배합한 산란계 사료에 오메가-3 불포화 지방산을 함유한 오일을 총 사료 무게중 3 내지 10중량% 혼합하고 이 혼합된 사료를 산란계에 공급하여 이 산란계로부터 오메가-3 불포화 지방산이 다량 함유된 계란을 제조하는 방법을 기술하고 있다. 한국특허공고 제95-11789호는 오메가-3 지방산이 풍부한 들깨유를 전체 조성물중 3 내지 10중량% 함유되도록 들깨, 들깨유 또는 들깨박을 첨가시켜 고농도의 오메가-3 지방산을 함유하는 난 생산용 사료를 만들고 이를 급여하여 혈중 콜레스테롤 함량을 저하시키는 등의 작용을 하는 오메가-3 지방산이 다량 함유된 특수한 난을 제조하는 방법을 기술하고 있다. 한국특허공고 제95-10933호는 유채종실과 들깨를 총 배합사료의 중량당 6.0 내지 8.0중량% 및 2.0 내지 4.0중량%의 비율료 함유하는 사료를 산란계에 급여하여 오메가-6 지방산 대 오메가-3 지방산(LNA, EPA, DPA, DHA)의 비율이 3 내지 7:1로 조정된 계란을 제조하는 방법을 기술하고 있다.Recently, various attempts have been made to increase the transition into eggs by fortifying some vitamins and fatty acids in the feed for the purpose of improving the added value of eggs. Korean Patent No. 87081 relates to a feed composition for the manufacture of special eggs containing a large amount of vitamin A, selenium, and vitamin E, which is well digestible and improves normal growth or health when ingested, and prevents disease. This method describes the preparation of eggs by administering this feed to laying hens with the addition of 30,000 IU of sugar A, 1.16 mg to 8.16 mg of selenium, and 30 mg to 5 mg of vitamin E. Korean Patent Publication No. 92-7672 discloses a fat feed additive that increases the content of omega fatty acids and lowers cholesterol content in meat produced by feeding feed to livestock. Korean Patent Publication No. 93-11396 teaches laying hen formulated feed containing EPA + DHA fortifying additives and a method for producing eggs in which the physiologically effective EPA + DHA is contained in egg yolk by effectively feeding the feed. Korean Patent Publication No. 95-13949 discloses an omega-3 unsaturated fatty acid oil mixed with 3-10 wt% of the total feed weight in a laying hen based on cereals, and feeding the mixed feed to the hen. A method for preparing eggs containing large amounts of omega-3 unsaturated fatty acids is described. Korean Patent Publication No. 95-11789 is for egg production containing high concentrations of omega-3 fatty acids by adding perilla, perilla oil or perilla seed to contain perilla oil, which is rich in omega-3 fatty acids, in the total composition. It describes how to make special eggs containing large amounts of omega-3 fatty acids, which are made by feeding and feeding them to lower blood cholesterol. Korean Patent Publication No. 95-10933 discloses omega-6 fatty acids versus omega-3 by feeding hens a diet containing 6.0-8.0% by weight and 2.0-4.0% by weight of rapeseed seed and perilla per weight of the total feed. A method for preparing eggs is described wherein the ratio of fatty acids (LNA, EPA, DPA, DHA) is adjusted to 3 to 7: 1.
L-카르니틴은 그 영양적 중요성 및 잠재적 가치가 최근에 이르러 광범위하게 밝혀지고 있다. 유럽 및 북미지역에서는 가장 보편화되어 있는 특수 목적용 기능성 건강 보조제 중의 하나로 자리잡고 있다. 현재까지 밝혀진 L-카르니틴의 생리적 주요기능은 체내에서의 에너지 발생을 위한 세포의 미토콘드리아에서의 장쇄지방산의 산화를 촉진하고, 심장근육이나 정자 내에서 주요 에너지 공급원인 활성화된 아세틸기의 저장 수단으로 작용하며, 세포내 자유기(free radical) 및 철이온의 착화에 의한 항산화제로 작용함으로써, 세포의 노화를 방지하며, 체내에서의 아세틸화 과정을 통해 아세틸-ℓ-카르니틴으로 전변되어 뇌 세포 등에서 중요한 신경전달물질로서 작용한다. 특히 심장근육의 지속적인 운동성을 위해 요구되는 에너지의 60 내지 80%는 심장근육 세포내 지방산의 산화에 의해 공급되기 때문에 L-카르니틴은 심장마비 예방제로서의 기능도 의학적 측면에서 인정되고 있다. 이밖에도 L-카르니틴은 간에서의 지방대사를 촉진시킴으로서 간경화증 및 지방간 예방 효과도 보고되고 있다. 따라서 이러한 L-카르니틴의 영양 기능적 특성을 중요한 식품중의 하나인 계란에 이용할 경우 특수 목적에 부합되는 기능성 란으로서의 계란의 부가가치를 높일 수 있을 뿐만 아니라 국민건강의 향상에도 기여할 수 있으리라 판단된다.L-carnitine has been widely discovered in recent years for its nutritional significance and potential value. It is one of the most common special purpose functional health supplements in Europe and North America. The main physiological functions of L-carnitine, which have been discovered to date, promote the oxidation of long chain fatty acids in the mitochondria of cells for energy generation in the body, and act as a storage means of activated acetyl group, which is a major energy source in the heart muscle or sperm. It acts as an antioxidant by the complexation of free radicals and iron ions in the cell, preventing aging of cells, and transforming it into acetyl-l-carnitine through acetylation in the body, which is important for brain cells. It acts as a transporter. In particular, since 60 to 80% of the energy required for the sustained motility of the heart muscle is supplied by the oxidation of fatty acids in the heart muscle cells, L-carnitine has also been recognized in the medical aspect as a cardiac arrest agent. In addition, L-carnitine has been reported to prevent liver cirrhosis and fatty liver by promoting fat metabolism in the liver. Therefore, if the nutritional functional properties of L-carnitine are used for eggs, one of the important foods, it is expected to not only increase the added value of eggs as functional eggs for special purposes but also contribute to the improvement of national health.
그러나, L-카르티닌의 영양적 기능적 중요성은 오래 전부터 인식되었으나 L-카르니틴의 상업적 대량생산이 이루어지지 않아 사료첨가제로서의 활용이 그 동안 제한되어 왔으며, L-카르니틴의 잠재적 기능의 중요성 및 응용성에 대한 이해의 부족으로 L-카르니틴의 영양적 기능적 목적을 중심으로 한 기능성 란의 개발이 이루어지지 않았다. 게다가 순수한 활성형태의 L-카르니틴의 확보와 이의 급여를 통한 계란내로의 이행효율 확대방법 및 이를 위한 사료내 적정 첨가수준 설정 및 배합설계가 어려웠다. L-카르니틴은 체내에서 에너지공급을 위한 장쇄지방산의 산화에 있어서 필수적인 영양소이나 식물성 사료원료 내에서는 거의 존재하지 않기 때문에 동물의 체내에서 요구되는 양은 자체적으로 합성되어 공급되어져야 한다. 체내에서 L-카르니틴의 합성은 필수 아미노산인 라이신으로부터 비롯되지만, 체내에서의 L-카르니틴의 합성은 여러 요인에 의해 제한을 받게 되며, 계란내로의 이행도 제한적인 수준에 그치고 만다. 따라서 활성형 L-카르니틴의 적정수준 첨가 및 사료성분조정에 의한 동물체내에서의 L-카르니틴의 이용효율의 증가는 결과적으로 계란내로의 이행효율을 증가시키게 되어 인체 영양에 있어서 중요한 기능을 나타내게되는 기능성 란으로서의 활용 잠재성 및 부가가치를 향상시키게 된다. 미국특허 제5362753호는 사료에 L-카르니틴을 사료에 첨가하고 이 사료를 산란계에 급여하여 난황내 L-카르니틴의 함량을 높여 병아리의 부화율을 3 내지 5% 개선시킬 수 있음을 교시한다. 그러나 본 특허는 계란내로의 L-카르니틴의 이행효율을 높일 수 있는 방안을 구체적으로 제시하지 못하고 있다.However, the nutritional and functional importance of L-cartinine has been recognized for a long time, but the commercial use of L-carnitine has not been achieved, so its use as a feed additive has been limited for some time, and the importance and applicability of the potential function of L-carnitine has been limited. Lack of understanding prevented the development of functional eggs centered on the nutritional and functional purposes of L-carnitine. In addition, it was difficult to secure the pure active form of L-carnitine and to increase the efficiency of transition into eggs through its feeding, and to set the proper level of feed in the feed and to design the formulation. Since L-carnitine is rarely present in nutrients or vegetable feedstock which is essential for the oxidation of long chain fatty acids for energy supply in the body, the amount required in the body of the animal must be synthesized and supplied by itself. The synthesis of L-carnitine in the body comes from lysine, an essential amino acid, but the synthesis of L-carnitine in the body is limited by several factors, and the transition into eggs is limited. Therefore, the increase in the utilization efficiency of L-carnitine in the animal body by the addition of the appropriate level of active L-carnitine and the adjustment of the feed ingredient result in an increase in the transfer efficiency into the egg, which is an important function in human nutrition. Improve the potential and value added as a column. U.S. Patent No. 5362753 teaches that L-carnitine can be added to feed and fed to laying hens to increase the content of L-carnitine in egg yolk to improve the hatching rate of chicks by 3-5%. However, the patent does not specifically suggest a method for improving the transfer efficiency of L-carnitine into eggs.
영양학적으로 인체가 요구하는 특정 기능성 물질인 L-카르니틴이 계란내에 효율적으로 이행되도록 적정한 사료를 개발하고 이러한 사료를 산란계에게 급여하여 고함량의 L-카르니틴이 함유된 계란의 제법 개발이 요구되고 있다. 본 발명자는 옥수수, 대두박, 채종박, 면실박, 옥글루텐, 옥배아박, 어분 및 우지로 구성된 기초사료에 미생물의 발효에 의해 생산되는 활성형의 L-카르니틴을 일정량 첨가하고 이 사료를 산란계에 일정기간 이상 급여함으로써 L-카르니틴이 상당히 효율적으로 계란내로 이행되고 고함량의 L-카르니틴을 함유한 계란을 얻을 수 있음을 발견하였다. It is necessary to develop a suitable feed for the efficient implementation of L-carnitine, which is a nutritionally specific functional substance required by the human body, and to feed eggs to laying hens to develop an egg-containing high content of L-carnitine. . The present inventors add a certain amount of active L-carnitine produced by fermentation of microorganisms to a basic feed consisting of corn, soybean meal, rapeseed meal, cottonseed meal, ox gluten, jade germ meal, fish meal and tallow, and feed the feed to the laying hens. It has been found that by feeding over a period of time, L-carnitine can be transferred into eggs quite efficiently and eggs containing high content of L-carnitine are obtained.
본 발명은 옥수수, 대두박, 채종박, 면실박, 옥글루텐, 옥배아박, 어분 및 우지로 이루어진 기초사료에 미생물의 발효에 의해 생산된 활성형 L-카르니틴 30ppm 이상을 첨가하고 이 사료를 산란계에 1주 이상 급여함을 특징으로 하는 L-카르니틴 고함량 계란의 제조방법을 제공한다. L-카르니틴의 바람직한 첨가 수준은 50ppm 이상, 보다 바람직하게는 100ppm 이상이다. The present invention adds more than 30ppm of active L-carnitine produced by the fermentation of microorganisms to the basic feed consisting of corn, soybean meal, rapeseed meal, cottonseed meal, ox gluten, jade germ meal, fish meal and tallow, and feed the feed to the laying hens. It provides a method for producing a high L-carnitine egg, characterized in that more than one week. The preferred addition level of L-carnitine is at least 50 ppm, more preferably at least 100 ppm.
본 발명은 하기 실시예로 구체적으로 예시된다.The invention is specifically illustrated by the following examples.
실시예 1 내지 3Examples 1 to 3
L-카르니틴의 첨가수준을 달리하여 산란계에게 급여했을 때 급여기간에 따른 계란내로의 L-카르니틴의 이행수준을 조사하기 위해 다음과 같은 실험을 수행하였다.The following experiments were conducted to investigate the level of L-carnitine in eggs according to the feeding period when fed to laying hens with different levels of L-carnitine.
- 시험 동물: IsaBrown(49주령): 2,880수 (240수 ×3반복 ×4처리구)Test animals: IsaBrown (49 weeks old): 2,880 trees (240 trees × 3 repetitions × 4 treatments)
- 시험 시간: 6주(42일)-Exam time: 6 weeks (42 days)
- 기초 사료: 옥수수, 대두박, 채종박, 면실박, 옥글루텐, 옥배아박, 어분, 우지-Basic feed: corn, soybean meal, rapeseed meal, cottonseed meal, jade gluten, jade germ meal, fish meal, tallow
- 사료내 L-카르니틴의 함량: 표 1-L-carnitine content in feed: Table 1
[표 1]TABLE 1
위의 제조된 시험사료를 산란계에 급여했을 때 급여기간에 따른 난황내 L-카르니틴의 함량은 표 2에서 보는 바와 같다.The content of L-carnitine in egg yolk according to the feeding period when the prepared test feed was fed to laying hens is shown in Table 2.
[표 2]TABLE 2
표 2에서 보는 바와 같이 시험 사료를 급여하기 전 난황내 L-카르니틴의 함량은 6.78ppm이었던 반면에 시험사료 급여 1주일 후 처리구별 난황내 L-카르니틴의 함량은 각각 7.3, 8.8, 9.67 및 11.5ppm으로써 L-카르니틴 급여에 의한 증가율은 각각 7, 30, 43 및 70%이었다. 즉, L-카르니틴 첨가 사료 급여 1주일 후 난황내 L-카르니틴의 함량 증가는 30내지 70%로서 L-카르니틴이 매우 효율적으로 난황내로 이행됨을 알 수 있다. 시험개시 7 내지 42일에 있어서 0, 50, 100 및 200ppm의 L-카르니틴 첨가수준에 따른 각 처리구별 난황내 L-카르니틴의 평균 함량은 각각 6.96, 9.33, 10.58 및 13.15ppm으로써 0일 기준에 비해 각각 3, 38, 56 및 94%가 증가됨을 나타내었다. 그리고 급여기간에 따른 각 처리구별 난황내 L-카르니틴의 함량변화는 도1에서 보는 바와 같다. L-카르니틴 첨가구의 경우 난황내 L-카르니틴 함량은 급여 3주 후에 최고 수준에 달하여 그후 지속되는 경향을 보인 반면에 무 첨가구의 경우에는 시간이 지날수록 다소 감소하는 경향을 보였다.As shown in Table 2, the content of L-carnitine in egg yolk before feeding the test diet was 6.78 ppm, whereas the content of L-carnitine in egg yolk by treatment group after 1 week of feeding was 7.3, 8.8, 9.67 and 11.5 ppm, respectively. The rate of increase by L-carnitine supplementation was 7, 30, 43 and 70%, respectively. That is, one week after feeding L-carnitine supplemented feed, the content of L-carnitine in egg yolk increased from 30 to 70%, indicating that L-carnitine was efficiently transferred into egg yolk. The average content of L-carnitine in egg yolks of each treatment group was 7.96, 9.33, 10.58 and 13.15 ppm, respectively, depending on the level of 0, 50, 100 and 200 ppm of L-carnitine added at 7 to 42 days from the start of the test. 3, 38, 56 and 94% increase, respectively. And the change in the content of L-carnitine in yolk for each treatment group according to the feeding period is as shown in FIG. In case of L-carnitine supplemented group, the content of L-carnitine in egg yolk reached the highest level after 3 weeks of feeding, and tended to be sustained thereafter.
이상의 결과로부터 본 발명의 방법은 계란내의 L-카르니틴의 함량을 일반란에 비해 약 30% 이상 높게 함유하는 계란을 제공하므로 산업적으로 특히 양계업에 매우 유용할 것으로 기대된다.From the above results, the method of the present invention is expected to be very useful industrially, especially in poultry farming, since it provides eggs containing about 30% or more of L-carnitine content in eggs.
도1은 기초사료에 L-카르니틴 첨가수준에 따른 난황내 L-카르니틴 함량의 변화를 보여주는 그래프이다 (◆ 0ppm; ● 50ppm; ▲ 100ppm; ■ 200ppm).1 is a graph showing the change of L-carnitine content in yolk according to the level of L-carnitine added to the basic feed (◆ 0ppm; ● 50ppm; ▲ 100ppm; ■ 200ppm).
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