JPS63264520A - Production of sheet-like cataplasm - Google Patents

Abstract

PURPOSE:To obtain the titled cataplasm prevented in volatilization and oxidation of active ingredients even in long storage, by extending solution-like plaster into dish vessels continuously connected in two numbers or more, pressing a sheet-like support on the semigel-like plaster, further piling a film for lid material up on the support and sealing the plaster. CONSTITUTION:A solution-like or semigel-like plaster 4 containing active ingredients is packed in a definite amount into dish vessels 1 having arbitrary shape and connected in two numbers or more and stretched in uniform thickness to extend into the bottom wall of the vessel 1 and a sheet-like support 5 punched after adjusting into shape of the vessel is put on the semigel-like plaster 4 which is on the way to gelling and then film for lid material 3 is piled up, as necessary while encapsulating an inert gas such as nitrogen and bonded to a flange 2 of the dish vessel 1 to seal the vessel 1. Thereafter, perforation 8 is formed on the flange 2. When used, the contents are separated in the perforation 8 and the film for lid material 3 is peeled by holding it in notched part 9 and a cataplasm consisting of integrated plaster 4 and sheet-like support 5 is taken out and the effective face of the cataplasm is applied.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a method for manufacturing a sheet-like patch such as a medical or non-medical poultice or a cosmetic pack.

[Conventional technology]

BACKGROUND ART Many sheet-like adhesives such as poultices and cosmetic packs that are applied to affected areas for the purpose of treating bruises, sprains, etc. or relieving stiff shoulders have been commercially available.

This type of sheet-like adhesive is prepared by spreading the poultice paste on a sheet-like support such as cloth or non-woven fabric, and covering the medicinal surface with an appropriate protective film to protect it before use. The film can be peeled off and applied immediately to the affected area.

The conventional method for manufacturing sheet-like adhesives is to spread a semi-gel-like adhesive paste that is in the process of transitioning from a solution to a gel onto a sheet-like support, and then cover the effective surface with an appropriate protective film. It is manufactured by coating the material with a coating and then cutting it into a predetermined size. And its packaging form.

Multiple sheets of adhesive are made into one packaging unit and are sealed inside a multilayer film containing metal foil such as aluminum foil or a gas-impermeable flexible material such as soft plastic film that is heat-sealed on all sides. .

[Problem that the invention seeks to solve]

In the conventional manufacturing method for sheet-like adhesives as described above, multiple sheets are packaged in a single bag, so if the user wants to store the remainder after opening the bag repeatedly, the unsealed part must be folded. However, if stored for a long time, volatile medicinal ingredients, active ingredients such as cosmetic ingredients, moisture, etc. will evaporate to a large extent and the quality will deteriorate. For this purpose, inert gas such as nitrogen is sometimes sealed inside the bag, but once the bag is opened, air enters the bag and the active ingredients are oxidized, resulting in a decrease in quality. It's easy to do.

Furthermore, in conventional manufacturing methods, adhesives with large areas are cut into predetermined sizes, so most of the adhesives are rectangular and tend to peel off from the corners after being applied. If you want to make it round, circular, or any other shape, in the conventional method, the sheet-like adhesive must be punched out with a die of a predetermined shape, so the scraps punched out with the die are wasted. There were problems such as.

The object of the present invention is that the adhesive can be manufactured in a series of steps from the solution of the adhesive to the forming and packaging of the adhesive sheet, and that the active ingredients of the adhesive sheet will not volatilize or oxidize even during long-term storage. To provide a method for producing a sheet-like adhesive that can maintain quality over a long period of time without causing any waste such as scraps.

[Means for solving problems]

In the present invention, a solution-like or semi-gel-like paste containing an active ingredient is spread in two or more consecutive dish-like containers of arbitrary shapes, and the paste becomes a gel in each dish-like container. Manufacture of a sheet-like adhesive characterized by pressing a sheet-like support punched out to fit the shape of each container onto a semi-gel-like paste in the middle, and then overlaying a lidding film and sealing it. It's a method.

The adhesive paste used in the present invention is in the form of a solution or semi-gel containing active ingredients such as medicinal ingredients and cosmetic ingredients, and is gelled by standing, heating, cooling, cross-linking monopolymerization, etc. A material that changes from semi-gel-like to gel-like depending on the method used can be used. Such plasters include proteins such as gelatin, casein, albumin, and sericin; gum arabic,
Gum tragacanth, sodium alginate, corn starch, methylcellulose, ethylcellulose, hydroxyethylcellulose, carboxymethylcellulose, dextrin, carboxymethyl starch, soluble starch, polyvinyl alcohol, sodium polyacrylate,
Water-soluble polymer solutions such as polyacrylic acid, methoxyethylene maleic anhydride copolymer, polyvinyl ether, polyvinylpyrrolidone, polyethylene glycol, polypropylene glycol, polyacrylamide, water-soluble alkyd, polyethyleneimine, sodium polyphosphate, water glass; or Inorganic fillers such as kaolin, bentonite, zinc white, and titanium dioxide are added to these mixed solutions;
Moisturizers such as glycerin or propylene glycol:
and, if necessary, adhesives such as rosin, ester gum, polybutene, and polyisobutyne, aldehyde compounds such as N-hydroxysuccinimide compounds, geltaraldehyde, glyoxal, dialdehyde starch, acetaldehyde, isocyanate compounds, epoxy compounds, and chlorides. Crosslinking agents such as aluminum, aluminum sulfate, aluminum nitrate, and potassium alum are added, and methyl salicylate, glycol salicylate, and d
-camphor, lye camphor, borneol, pepper oil,
Menthol, eucalyptus oil, glycyrrhetinic acid, glycyrrhizic acid and its salts, nonylic acid vanilylamide, cabsaicin, nicotinic acid benzyl ester, capsicum powder, capsicum extract, capsicum tincture, turpentine oil, arnica tincture, isothipendyl hydrochloride, diphenhydramine, diphenhydramine hydrochloride , diphenhydramine lauryl sulfate, diphenhydramine salicylate,
Chlorpheniramine, Chlorpheniramine Maleate,
4,5-diphenylimidazole, nitroglycerin,
Scopolamine, indomethacin, ketoprofen, isosorbide nitrate, pentaerythritol tetranate, estradiol, clonidine, adriamycin, vitamin E
, glycyrrhizin, γ-oryzanol, and other medicinal ingredients: or fragrance, peppermint oil, Q-menthol, nutrients, vitamin A, vitamin D, squalane, lanolin, avocado oil, olive oil, dimethylsiloxane, methylphenylpolysiloxane, silicone oil, egg white. Dry powder of boiled egg yolk, ethanol, parabens, tocopherol acetate (vitamin E), stawarane, ceresin, liquid paraffin, turdle oil, mink oil, beeswax, spermaceti, stearic acid, palmitic acid, isopropyl myristate. , octyldodecyl myristate, sodium carboxymethylcellulose, collagen, polyethylene glycol, lauric acid jetanolamide, polyoxyethylene lanolin, preservatives, gibberellin, proteolytic enzymes.

It is obtained by blending and kneading active ingredients such as cosmetic ingredients such as pigments, antioxidants, and buffering agents.

The above-mentioned dish-shaped container for spreading the plaster is a container having two or more consecutive dish-shaped recesses of any shape, and each container is separated by a flange etc. to become an independent container, and it is suitable for sewing machines. Preferably, it can be separated by eye or the like. The shape of such a dish-shaped container is preferably flat, and it can be made of any material. Such containers include, for example, ethylene-vinyl alcohol copolymers; butadiene-methylacrylonitrile copolymers, polyvinylidene chloride, and gas-impermeable flexible materials such as amorphous nylon and metal foils such as aluminum foils. or polyethylene such as polypropylene, high-density polyethylene, low-density polyethylene, ultra-high molecular weight polyethylene, polyester, modified nylon, 6
- Nylon, nylon such as 46-nylon, acrylic homopolymer or acrylic copolymer such as methacrylic resin, acrylic resin, tetrafluoroethylene resin, tetrafluoroethylene-hexafluoropropylene copolymer, tetrafluoroethylene-perfluoroalkyl vinyl ether copolymer Polymers, ethylene-tetrafluoroethylene copolymers, chlorotrifluoroethylene resins, fluororesins such as polyvinylidene fluoride and polyvinyl fluoride, polycarbonates, polyvinyl chloride, chlorinated polyvinyl chloride, polyvinyl chloride, high impact polystyrene , polystyrene such as biaxially oriented polystyrene, polyvinyl alcohol, acrylonitrile-butadiene-styrene copolymer (ABS resin), polyethylene terephthalate, polybutylene terephthalate.

Polyphenylene sulfide, modified polyphenylene oxide, melamine resin, urea resin, phenolic resin,
Epoxy resin, unsaturated polyester resin, diallyl terephthalate resin, silicone resin, silicone rubber, polyurethane, polyimide, polyetherimide, aromatic polyamideimide resin, polyamide, polyacetal,
polyether sulfone, polyether ether ketone,
polyarylate, polysulfone, polymethylpentene,
Oxybenzoyl polyester, polyolefin resin,
Sheets that use gas-permeable flexible materials such as polyparabanic acid resin, thermoplastic elastomer, cellophane, and easy-open sealants alone, and multilayer sheets made by laminating 2 to 10 of these sheets together. Some are molded into dish-shaped containers of arbitrary shapes.

Furthermore, the film for the lid used in the present invention may be made of the same material as the above-mentioned dish-shaped container.

Next, the sheet-like support (backing) used in the present invention is a sheet made of a material that can evaporate moisture, such as cloth, nonwoven fabric, paper, sfumos, flannel, etc., in consideration of the cooling effect of the adhesive. Films that use a single support, metal foil such as aluminum foil that prevents the evaporation of moisture and active ingredients, various plastic films, etc., and multilayer films that are made by laminating 2 to 10 of these films together. There are things. As the plastic film, the same materials as mentioned above for the dish-shaped container can be used.

The method for producing a sheet-like adhesive of the present invention involves preparing a solution-like or semi-gel-like paste containing the above-mentioned active ingredient as a final product.
A semi-gelatinous state in the process of being filled with a certain amount into a series of dish-shaped containers of any shape, stretched and spread to a uniform thickness, and gelled by leaving, heating, cooling, crosslinking, polymerization, etc. A sheet-like support punched out to match the shape of each container is placed on top of the paste and pressed, and then a lidding film is stacked on top of the container while filling in an inert gas such as nitrogen as necessary. Glue it to the flange of the shaped container and seal it so that each container is independent. Then, perforations or the like are formed in the flange portions etc. that partition each container, so that each container can be separated.

The sheet-like adhesive thus produced can be used as a medical or non-medical poultice, a cosmetic pack, or the like, depending on the type of active ingredient. In either case, separate each container, or peel off the lid film for each container without separating, remove the sheet-like support with the plaster attached, and apply the effective side of the plaster to the skin. use.

〔Example〕

Examples of the present invention will be described below. 1 to 3 show different embodiments, and (,) is a plan view of two or more dish-shaped containers in a row, and (b) is a cross-sectional view of the whole. In the figure, 1 is a dish-shaped container, 2 is a flange thereof, 3 is a lidding film, 4 is a plaster containing an active ingredient,
5 is a sheet-like support (backing), 6 is an adhesive or adhesive, 7 is a rib for increasing the strength of the container 1 and the surface area of the plaster 4, 8 is a perforation, 9 is a notch, 10 0 is a linear protrusion, a plate-shaped container 1, a film for lid material 3. The sheet-like support 5 and the like are formed into arbitrary shapes as shown in FIGS. 1 to 3. Two or more dish-shaped containers 1 are connected and separated by flanges 2 so that each container is independent. If necessary, ribs 7 are provided on the bottom wall of the container 1, and linear protrusions 10 are provided on the flange 2.

The method for producing a sheet-like adhesive is to fill a certain amount of a solution or semi-gel paste 4 into a dish-shaped container 1 formed in the shape shown in FIGS. Stretch it to a uniform thickness and spread it on the bottom wall of container 1, leave it, heat it, cool it,
Crosslinking 1 A sheet-like support 5 punched out to fit the shape of each container is placed on the semi-gel-like paste 4 which is in the process of being gelatinized by polymerization or other means, and is then pressure-bonded. While filling with inert gas such as nitrogen,
The lidding film 3 is overlapped and adhered to the flange 2 of the dish-shaped container 1 to seal it. Thereafter, perforations 8 are formed in the flange 2.

A method of bonding the dish-shaped container 1 and the lidding film 3 is to apply adhesive or pressure-sensitive adhesive 6 to the flange 2 of the container 1 or the portion of the lidding film 3 that contacts the flange 2, and press and seal. Alternatively, a lidding film 3 is placed on the flange 2 of the container 1, and a heated metal plate or metal wire is pressed onto the top of the film 3 at a certain pressure for a certain period of time to perform thermocompression bonding.

In these cases, by providing the linear protrusion 10 on the flange 2, adhesive force and sealing performance can be improved.

When sealing is performed by thermocompression bonding, the heating temperature of the metal plate or metal wire, the pressure and time during thermocompression bonding, the material of the part of the flange 2 of the container 1 that comes into contact with the lidding film 3, and the lidding material are determined as necessary. By arbitrarily changing the combination of the materials of the portion of the film 3 that comes into contact with the container 1, the adhesive strength between the container 1 and the lidding film 3 can be changed arbitrarily. In this way, it is possible to manufacture lidding film 3 with adhesive strength that allows it to be easily pulled off by pinching it by hand, to adhesive strength that is so strong that it is difficult to peel it off even if you try to peel it off.

The sheet-like adhesive thus produced can be carried as is or after being cut at the perforations, and when used, it is folded at the cut 9, the lidding film 3 is peeled off, and the adhesive sheet 4 and sheet-like support 5 are removed. Take out the sheet-like adhesive with which the adhesive is integrated and apply the effective side.

The above-mentioned sheet-like adhesive has the following features.

(1) By changing the shape of the container 1, it is possible to manufacture adhesives of any size, shape, and thickness.

(2) In conventional manufacturing methods, the corners of the adhesive are rounded.

If it were made into a circular shape, the remaining part of the paste 4 that was punched out would be generated as waste, and the collection of the paste 4 would be poor.However, in the manufacturing method of the present invention, a fixed amount of the paste 4 is put into the container 1. Since it only needs to be filled, the 1-minute retention time will be high.

(3) Since each patch is individually sealed, the user can always use a fresh patch, and this prevents moisture and volatile active ingredients from evaporating after opening, unlike conventional adhesives. There is no deterioration in quality during storage, such as oxidative deterioration of active ingredients caused by oxygen in the air.

(4) After the conventional adhesive is opened, the unique odor of the volatile active ingredient in the adhesive is emitted into the surrounding area during storage, so users have to be careful about where it is stored after opening. However, the adhesive manufactured by the manufacturing method of the present invention is
Since each piece is completely sealed independently, it can be easily stored in your home refrigerator.

(5) In order to improve the adhesion of the plaster 4 to the skin, the bottom of the container 1 can be made uneven to increase the surface area of the plaster 4.

(6) Since two or more containers 1 are connected, a plurality of adhesives can be manufactured at the same time, and at the stage of use, they can be cut to any size and carried.

〔Effect of the invention〕

As described above, according to the present invention, two or more consecutive molding containers can also be used as packaging materials.

Adhesive adhesives can be formed and packaged efficiently through a series of simple processes, the active ingredients can be prevented from volatilization and oxidation even during long-term storage, the quality can be maintained for a long time, and materials can be used effectively. effective.

[Brief explanation of drawings]

1 to 3 show other embodiments, respectively (a
) is a plan view of two or more dish-shaped containers. (b) is a cross-sectional view of the whole. In each figure, the same reference numerals indicate the same or equivalent parts, 1 is a dish-shaped container, 2 is a flange, 3 is a lidding film, 4 is a plaster, 5 is a sheet-like support, 8 is a perforation, and 9 is a It is a notch. Agent Patent Attorney Sei Yanagihara 1 Figure 1: S, Shape 2: Fra>ㅅ 3: 5 hahofil gourd 4: 11 A Hon 5, Sheet A Inukyu Collar Right To 8゛Mishi/Eye 9: Seven Swords Including

Claims (3)

[Claims] (1) A solution-like or semi-gel-like paste containing an active ingredient,
The paste is spread into two or more consecutive dish-shaped containers of any shape, and punched out according to the shape of each container on the semi-gel-like paste that is in the process of gelling in each dish-shaped container. A method for producing a sheet-like adhesive, which comprises pressing a sheet-like support, and further overlaying and sealing a lidding film. (2) The manufacturing method according to claim 1, wherein the flanges of two or more successive dish-like containers are fixed to a lidding film to seal each dish-like container. (3) The manufacturing method according to claim 1 or 2, in which two or more dish-shaped containers connected in a row can be separated from each other.