JPS62239058A - Automatic analyzer - Google Patents

Abstract

PURPOSE:To enable multi-purpose multinominal measurement in which the measurement of the concn. of the drug in blood and immunological analysis can be executed with and at high accuracy and high speed with the same instrument by using many samples, many kinds of reagents, many reaction tubes, etc. CONSTITUTION:A sampling pipetter 9 operates and a pipetting nozzle at one end sucks a required amt. of specimen from the inside of a sample vessel and dispenses the specimen into the reaction tube 5. On the other hand, the specimen is used as a diluting specimen for a certain measuring item and after a required amt. of the diluting specimen is sucked upon operation of the pipetter 9, the specimen is dispensed into the tube 5. The pipetting nozzles at the respective one end of the 1st reagent pipetter 11 and 2nd reagent pipetter 13 is operate to suck and the 1st and 2nd reagents, then pour the same into the tube 5 when the 1st reagent bottle 10 and 2nd reagent bottle 8 corresponding to the measuring item arrive at the prescribed sample suction position. The reactive liquids dispensed into the tube 5 are stirred by the air fed therein. the measuring light transmitted through the reaction tube in the tube 5 is separated into its spectral components by a concave diffraction grating of an optical measuring instrument, by which the measurement is made. The concn. is calculated by a microcomputer.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to an automatic analyzer, and in particular, it can be used for biochemical analysis, electrolyte analysis, blood drug concentration measurement, and immunological analysis using the same device. This invention relates to an automatic analyzer capable of performing multi-purpose and multi-item measurements that can perform high-accuracy, high-speed analysis.

[Prior Art] Various automatic analyzers of this type have been proposed in the past, and biochemical analyzes and the like are performed using simple and miniaturized devices.

For example, a sample table holding a required number of sample containers and dilution tubes, a rotatable reaction table on the outer circumference of the table, and a first reagent table and a second reagent table near the reaction table. a sampling pipette device for selectively dispensing a sample or a diluted sample into a reaction tube or a dilution tube, a first reagent pipette device and a second reagent pipette for dispensing a first reagent and a second reagent into the reaction tubes, respectively; Each device was placed near the reaction table, and colorimetric measurements were performed using an optical measuring device. In this way, biochemical analysis and the like can be performed using the automatic analyzer. (For example, see Japanese Patent Application No. 139553/1983.) An automatic analyzer uses a large number of samples, various types of reagents, and a large number of reaction tubes to handle a large number of measurement items. There are demands for speed, accuracy, simplicity of the device, etc.

[Problems to be Solved by the Invention] However, the above-mentioned conventional automatic analyzers disclosed in, for example, Japanese Patent Application No. 139553/1980, cannot quickly carry out operations for sampling large quantities, dispensing reagents, and reaction operations. Moreover, there was a problem in that it could not be done easily. In addition, there is a problem in that the structure of the optical measuring device becomes complicated, such as requiring a correction device for the difference in light amount between the filters.

The present invention solves these conventional problems,
Sampling and reagent dispensing operations, reaction operations, and optical measurements can be performed quickly and easily for a large number of samples, and can be used not only for biochemical analysis and electrolyte analysis but also for homogeneous immunology. The purpose is to provide an excellent automatic analyzer that can perform multi-purpose and multi-item measurements that can perform high-accuracy, high-speed analysis of blood drug concentration measurement using antigen-antibody method or fluorescence method and immunological analysis using the same device. It is.

[Means for Solving the Problems] In order to achieve the above object, the present invention holds a plurality of sample containers for general specimens on the outer periphery and has the same number of dilution tubes as the sample containers for general specimens on the intermediate periphery. A turret-shaped sample table that holds a sample container for an emergency specimen on its inner periphery, and a required number of reaction tubes arranged concentrically on the outer periphery of the sample table so as to be rotatable in forward and reverse directions are held. a reaction table, a first reagent table and a second reagent table respectively arranged near the reaction table, and the reaction table for selectively dispensing the specimen or diluted specimen in the sample container into the reaction tube or dilution tube. a sampling pipette device disposed adjacent to the table; and a system between the reaction table and the first reagent table for dispensing a required amount of the first reagent in the reagent bottle placed on the first reagent table into the reaction tube. a first reagent pipetting device disposed between;
A second reagent pipette disposed between the reaction table and the second reagent table for dispensing a required amount of the second or third reagent in the reagent bottle placed on the second reagent table into the reaction tube. The device, an optical measurement device that colorimetrically measures the reaction solution in the reaction tube and is placed in the middle consisting of a reaction table, a first reagent table, and a second reagent table, and a sampling pot is provided in the movement path of the sampling pipette device. The apparatus includes an electrolyte analyzer and a fluorescence analyzer placed near the reaction table.

[Function] The present invention has the following effects due to the above configuration. In other words, the sampling pipette device operates and the pipette nozzle at one end aspirates the required amount of sample from the sample container, then dispenses it into the reaction tube, and at the same time, the pipette nozzle at the other end is cleaned internally and externally. be done. Subsequently, the above-described sampling operation corresponding to the measurement item of the specimen is repeated. On the other hand, for a certain measurement item, the sample is diluted at a predetermined ratio as a diluted sample, and the sampling pipette device is activated to aspirate the diluted sample for the required amount of time from the dilution tube, and then dispense it into the reaction tube. Ru.

The types of specimens are classified into general specimens and emergency specimens i, depending on the degree of urgency of the clinical test, and emergency specimens are sampled with priority over general specimens. Next, when the first reagent bottle and second reagent bottle table corresponding to the measurement item arrive at the predetermined reagent suction position, the pipette nozzle at one end of the first reagent pipette device and the pipette nozzle at one end of the second reagent pipette device respectively After the first reagent and the second reagent are actuated and measured by suction, they are injected into the reaction tube. At about the same time, the pipette nozzle at each other end is cleaned internally and externally. The reaction solution dispensed into these reaction tubes is stirred by the movement of air bubbles generated by introducing air into the reaction tubes, thereby performing an operation for uniformizing and promoting the reaction. In the optical measurement device, the measurement light enters the light guiding hole of the reaction table and passes through the reaction liquid in the reaction tube, is separated by a concave diffraction grating, and is measured using a photodiode element, etc., and is then measured by a microcomputer. Concentration calculations are performed. As mentioned above, multiple sets of sample containers and dilution tubes for general samples and emergency samples can be held, and operations for reagent dispensing and reaction operations can be performed very quickly and easily according to a predetermined sequence. be able to.

[Example] Embodiments of the present invention will be described below with reference to the drawings.

1 and 2 show the configuration of an embodiment of the present invention. In Figures 1 and 2, X indicates an automatic analyzer,
Reference numeral 4 designates a turret-shaped sample table, 6 a reaction table placed on the outer peripheral side of the sample table 4, 7 a first reagent table placed near the reaction table 6, and 8 a second reagent table. Further, 9 is a sampling pipette device, 11 is a first reagent pipette device, and 13 is a second reagent pipette device, all of which are arranged adjacent to the reaction table 6. Reference numeral 14 denotes an optical measuring device disposed at an intermediate portion between the first reagent table 7 and the second reagent table 8. On the sample table 4, a plurality of sample containers 1 for general specimens are arranged on the outer periphery, then the same number of dilution tubes 2 are arranged on the middle periphery, and further sample containers 3 for emergency specimens are arranged concentrically on the inner periphery. A large number of each is maintained. The sample containers 1 and 3 contain the required amount of specimen (serum, urine, etc.) collected from the living body to be measured, and the dilution tube 2 contains diluted specimens obtained by diluting the specimen at a predetermined ratio. be accommodated. The turret-shaped sample table 4, reaction table 6, first reagent table 7, and second reagent table 8 are controlled to freely rotate in forward and reverse directions according to a predetermined sequence using drive devices 41, 61, 71, and 81, respectively. .

When the sample table 4 is rotationally driven by the drive device 41 and a predetermined sample container 1 reaches a predetermined sample suction position a, the sample in the sample container 1 is passed through the pipette nozzle 105 at one end of the sampling pipette device 9. After the required amount is aspirated, it is dispensed into the corresponding reaction tube 5 at the sample discharge position. When the sample in a predetermined sample container 3 is used, the sample table 4 is rotated and transferred to a predetermined sample suction position a' as shown in FIG. 104 moves and the pipette nozzle 105 at one end aspirates a required amount of the sample in the sample container 3, after which the sample is dispensed into the corresponding reaction tube 5 at the sample discharge position shown in FIG.

Furthermore, when storing a diluted specimen obtained by diluting the specimen in the sample container 1 or sample container 3 at a required ratio into the dilution tube 2, the holder 104 of the sampling pipette device moves in the same way as described above, and one end of the specimen is moved. Pipette nozzle 1 in
05 aspirates the specimen in the sample container 1 or the sample container 3, and then injects it into the dilution tube 2 as a diluted specimen.

Note that when the diluted sample is dispensed from the dilution tube 2 into the corresponding reaction tube 5, it is also dispensed via the pipette nozzle 105 at one end of the sampling pipette device 9 in accordance with the above operation.

Next, the first reagent table 7 and the second reagent table 8
, a plurality of first reagent bottles 10 and a plurality of second reagent bottles 12 used for the reaction are placed respectively, and when the reaction tube 5 into which the first sample has been dispensed comes to the first reagent discharge position f, the first reagent bottle 10 and the second reagent bottle 12 used for the reaction are placed. The reagent table 7 rotates and transfers the first reagent bottle 10 corresponding to the measurement item to the first reagent suction position d, and the first reagent is pipetted from inside the first reagent bottle 10 via the first reagent pipette device 11 to the pipette nozzle. 39, the first reagent pipette is transferred to the first reagent discharge position f, and the required amount is dispensed into the reaction tube 5. Next, when two pitches of the reaction table 6 are sent, a stirring pump (not shown) is sent to the stirring nozzle 41 which is arranged adjacent to the first reagent pipette 1 to the nozzle 39.
Air is sent through the reaction tube 5, and the reaction liquid inside the reaction tube 5 is stirred. Furthermore, the reaction tubes 5 are transferred at a required pitch,
When the second reagent discharge position q is reached, the second reagent table 8 rotates and transfers the reagent bowl 1 well 12 according to the measurement item to the second reagent suction position e, and the second reagent table 8 rotates and transfers the reagent bowl 1 well 12 according to the measurement item to the second reagent suction position e, and the second reagent table 8 rotates and transfers the reagent bowl 1 well 12 according to the measurement item to the second reagent suction position e. The second reagent is pipetted into the nozzle 4 through the pipetting device 13.
0, the second reagent pipette is transferred to the second reagent discharge position q, and the required amount is dispensed into the reaction tube 5. Subsequently, when two pitches of the reaction table 6 are fed, air is sent by a stirring pump (not shown) to the stirring nozzle 42 arranged in parallel with the second reagent pipette, and the reaction liquid in the reaction tube 5 is stirred. The stirring positions of the reaction solution using the first reagent and the second reagent on the reaction table 6 are respectively indicated by i.

The reaction solution in the above is sufficiently stirred by introducing air to generate bubbles and move the bubbles.
This is done to make the reaction uniform and promote it, and the stirring can be performed on the reaction table 6 without the whites of the reaction tubes 5 being transferred to the outside of the apparatus.

The optical measuring device 14 uses a multi-wavelength luminous intensity h1, and as shown in FIGS. 1 and 2, a light source lamp 141 is used.
The light passes through the condensing lens 142, enters the light guide hole 63 of the reaction table 6, and the measuring light transmitted through the reaction liquid in the reaction tube 5 is reflected by the reflecting mirror 143 and passes through the sleeves 1 to 144 to the concave diffraction grating. 145 and a plurality of light receiving elements 146, the current change of each wavelength is calculated by a microcomputer via an amplifier and an AD converter.

For optical measurement, the measurement wavelength for each item of all reaction tubes is adjusted every time the reaction table 6 rotates one rotation and one pitch.
Perform absorbance measurement. Therefore, the absorbance can be measured at each step up to the first nozzle position J of the reaction tube cleaning device 19 after stirring the second reagent, and the time course of the reaction can be obtained. Measurements can be made.

When this colorimetric measurement is completed, the reaction tube 5 reaches the first reaction tube cleaning position J, is cleaned by the reaction tube cleaning device 19, and is used again.

As mentioned above, since the optical measurement device 14 does not use a large number of filters that each convert to a different wavelength,
Not only can the device and operation for setting the optical path be omitted, but also the circuit for electrically correcting the difference in the light intensity of each filter can be omitted, making it possible to speed up measurement and simplify the structure. I can do it.

FIG. 3 is a detailed explanatory diagram of the 1-non-pull pipette 1 to the device 9. 1 Non-pull pipette 1 device 9 includes holders 10 that hold pipette nozzles 105 at both ends, respectively.
It is composed of a vertical drive device 101, a rotation drive device 102, and a telescopic drive device i03 of the holder 104, and the pipette nozzle 105 is arranged at both ends of the holder 104 at symmetrical positions with respect to the rotation axis 106. When transferring the samples and diluted samples from the sample containers 1 and 3 and the dilution tube 2 to the reaction tube 5, these samples are aspirated and weighed using the sampling pump 21 as shown in FIG. Transfer is performed using the drive device 101, rotary drive device 102, and telescopic drive device 103, and when the injection into the reaction tube 5 is completed, the flow path is changed by the solenoid valve 107, and the pipette nozzle 105 at the other end Cleaning is performed using the remaining amount of water pumped out by the bring pump 21. Thus, the υ-sampling speed going into the υ-sampling operation can be significantly increased.

FIG. 4 is a detailed explanatory diagram of the first reagent pipette 1 to device 11 and the second reagent pipette device 13, and the same reference numerals are used to describe parts having common configurations.

First reagent pipette 1 to device 11 and second reagent pipette 1 to
The device 13 is composed of a holder 205 that holds pipette nozzles 39 and 40 at both ends, a vertical drive device 201 of the holder 205, and a rotational drive device 202. The stirring nozzles 41 and 42 are arranged at both ends in symmetrical positions with respect to the rotating shaft 205. 10. When transferring the first reagent and second reagent from the second reagent bottle 12 to the reaction tube 5, these reagents are transferred by the first reagent pump 22 and second reagent pump 23 shown in FIG. Along with suction metering, the above-mentioned vertical drive device 2
01 and a rotary drive device 202 to perform the transfer,
When the injection into the reaction tube 5 is completed, the flow path is changed by the solenoid valve 203, and the pipette nozzle 39, 40 at the other end is cleaned by the remaining amount of water pushed out by the first reagent pump 22 and the second reagent pump 23. be exposed. Thus, the speed of reagent dispensing can be significantly increased.

The first and second reagents are measured by filling microsyringes (not shown) in the first reagent pump 22 and second reagent pump 23 with water, and separating the reagent and water through air. In addition, although not shown in the figure, the pipette nozzles 39 and 40 are equipped with liquid level sensors that change the vertical stroke to prevent the outside of the pipette nozzles 39 and 40 from being filled with more reagent than necessary. It looks like it won't get wet.

As mentioned above, 1] - Pulling pipette device 9
The first reagent pipette device 11 and the second reagent pipette device 13 are each equipped with a pipette nozzle at both ends, and the pipette nozzle at one end discharges a suction-side amount, and at the same time, the pipette nozzle at the other end discharges a suction-side amount. Since the pipette nozzle is cleaned, operations for sampling and reagent dispensing can be significantly speeded up.

When performing biochemical analysis using automatic analyzer X,
It is also possible to use the second reagent table 8 for the first or third reagent. In this case, reaction table 6 is
After dispensing the sample, rotate the required steps to the second reagent discharge position q
After dispensing the first reagent in the second reagent table 8, the operation of returning to the original position +1 is repeated. Similarly, the third reagent can be dispensed by rotating the reaction table 6 in forward and reverse directions.

Next, the case where electrolyte analysis is performed using automatic analyzer X will be described. An electrolyte sampling pot 1 is provided in the vicinity of the reaction table 6 and at a position C along the moving path of the sampling pipette I to the apparatus 9.

Electrolyte analysis can be performed in parallel with biochemical analysis;
By discharging the sample to be dispensed into the reaction tube 5 to the electrolyte limping pot position C, the electrode measurement device 18 automatically measures the sample, and the data is sent to the microcomputer 34 and printed together with the biochemical analysis results.

Also, a case will be described in which the automatic analyzer X is used to measure drug concentration during music. A fluorescence analyzer 15 is installed near the reaction table 6. The operation at this time is almost the same as that for biochemical analysis, but since fluorescence measurement cannot be performed while the reaction table 6 is rotating, the rotation is stopped and fluorescence measurement is performed. Although it is not possible to display the reaction time course, it is possible to perform highly sensitive micro-extrusion measurements.

-16= The fluorescence analyzer 15 is mainly used for precise measurement of the concentration of the drug during treatment, and it applies light from a light source that has passed through an interference filter for excitation light (e.g. 485 nm) to the reaction tube 5, which is proportional to the drug concentration. Filter the fluorescence using an interference filter (e.g. 525
nm) to the photodetector, converted to digital by an amplifier/AD converter, and then measured by a microcomputer at temperature t1.
I am doing calculations.

In FIG. 1, reference numeral 19 denotes a reaction tube cleaning device, which is disposed near the reaction table 6 between the one-pumping pipette device 9 and the bead cleaning/discarding device 17, and is installed on the reaction tube after the measurement operation has been completed. When the reaction tube 5 placed on the tube 6 reaches the cleaning position J, the cleaning pump device 24 discharges the cleaning liquid into the reaction tube 5 and suctions it to clean it, and discharges the waste liquid out of the system.Washing The operation is as follows: 8-stage cleaning is performed, alkaline detergent is injected into the second stage, acidic detergent is injected into the fourth stage, and pure water is injected into the other lines to ensure sufficient cleaning.

Furthermore, the case of performing enzyme immunoassay (FIΔ) using bead solid phase using automatic analyzer X will be described. 1st
In the figure, 16 indicates a bead table, and 17 indicates a bead washing/discarding device, which are arranged on both sides of the fluorescence analyzer 15 in the vicinity of the reaction table 6. FIG. 7 is a detailed explanatory diagram of the bead solid-phase EIA measuring device. 1 and 7, the bead table 16 is used when performing bead solid-phase EIA, and the bead table 16 includes a plurality of bead stockers 25 storing EIA beads 404 corresponding to measurement items.
The bead table 16 is rotated by a rotary drive device 403, and the beads 1 to 25 corresponding to the measurement items are rotationally transferred to the bead drop position k. The bead stocker 25 is equipped with a lever 405 for dropping the beads 404 one by one, and an electromagnetic solenoid 406 is used to drop the beads 404 into the reaction tube 5 according to the measurement item.
4 can be dropped one by one. The bead washing/discarding device 17 is used when performing bead solid-phase EIA, and is composed of a vertical drive device (not shown), a rotation drive device, a bead washing nozzle, and a bead suction nozzle. Wash the beads and discard the beads after measurement.

FIGS. 5 and 6 show an optical measuring device used for bead solid-phase EIA measurements.

Furthermore, the operation in bead solid-phase EIA measurement will be explained.

The reaction tube 5 into which the beads have been inserted is rotated and transferred to a sample dispensing position by the rotation of the reaction table 6, and the sample is dispensed by the sampling pipette device 9. After the required time has elapsed, the first reagent is dispensed by the first reagent pipette device 11 and stirred through two steps. After the required time has elapsed, the reaction tube 5 is cleaned/discarded by the bead cleaning/disposal device 17.
The beads are transferred to the disposal position and the beads are washed by discharging and suctioning the washing liquid into the reaction tube. Next, the reaction tube 5 is rotated to the second reagent discharge position, and the second reagent is dispensed by the second reagent pipette device 13. After the required time has elapsed, the nuclear reaction tube 5 is cleaned again in the bead cleaning/disposal device 7. Next, the third reagent on the second reagent table B is dispensed in the same manner, and after the required time has elapsed, it is measured by the optical measuring device 14.

After the measurement, the used beads are suctioned and discarded from the reaction tube 5 by the waste nozzle of the bead cleaning/disposal device 17, and the used reaction tube 5 is further cleaned by the reaction tube cleaning device 19 and used again. be given

FIGS. 5 and 6 show an optical measuring device 14 used for bead solid-phase EIA measurements. The optical measurement device 14 is attached with an optical path selection device 30B, and is capable of measurement for both normal biochemical analysis and bead solid-phase EIA. The optical path selection device 308 consists of a beam correction lens 306, four total reflection mirrors 307, and a vertical drive device 309, and is positioned at the bottom for normal measurement, and the light from the light source lamp 141 passes through the condenser lens 142. The measurement is then carried out by a multi-wavelength photometer Y after passing through a reaction tube 5 containing the liquid to be measured. Bead solid-phase EIA measurements are performed using the vertical drive device 309.
Optical path selection device 3 so that the light beam passes above beads 404
0B is positioned above and optical measurements are taken avoiding the beads. The optical path selection device 308 has the advantage that it can perform measurements with a small amount of reaction liquid in normal measurements, and can also perform measurements for bead in-phase EIA using the same multi-wavelength photometer.

Then, according to the predetermined sequence described in the examples,
The opening operation described above is performed using a control device.

In FIG. 1, the control device of the automatic analyzer
2, a microcomputer 33, and an operation panel 34,
It is composed of a personal computer 42 for data processing. Further, the personal computer 42 includes a CPtJ, a keyboard 35, a CRT display device 36, a magnetic disk storage device 37, and a printer 38 for printing measurement results. The magnetic disk storage device 37 stores required data such as measurement request items for clinical tests.

The temperature control device 31 is used to keep the reaction temperature of the reaction tube 5 constant and also controls the first and second reagent tables 7.8.
The temperature is controlled to be maintained at approximately 10°C using cold air to prevent deterioration of the reagents.

It goes without saying that the embodiments of the invention of this application are not limited to the above-mentioned embodiments.

[Effects of the Invention] As is clear from the above embodiments, the present invention can be applied to automatic analysis using a large number of samples, a large number of types of reagents, a large number of reaction tubes, etc., and corresponding to a large number of measurement items. It has the advantage of speed, accuracy, and simplicity of the device. Based on a predetermined sequence, the main parts used for analysis operations are placed close to each other and their operations are interconnected, allowing the transfer of samples, reagents, etc. over short distances. The analysis can be carried out in a short time, and compared to conventional automatic analyzers, the apparatus can be made more compact, and the speed and analytical ability can be significantly improved.

Since the sampling pot for electrolytic analysis is provided at a position on the movement path of the sampling pipette device, a separate sampling pipette device is not required, and the device can be simplified.

Furthermore, the present invention has devices for not only biochemical analysis but also electrolyte analysis, blood drug concentration measurement, fluorescence analysis, and enzyme immunoassay (EIA) using bead solid phase, which all have the same configuration. In the above-mentioned automatic analysis, it is possible to carry out continuous sample analysis with high accuracy and high speed, and the effects are great.

[Brief explanation of drawings]

FIG. 1 is a plan view of an automatic analyzer according to an embodiment of the present invention, FIG. 2 is a sectional view of the same device in FIG. 1, FIG. 3 is a schematic explanatory diagram of the sampling pipette device of the same device, and FIG. The figure is a schematic illustration of the first and second reagent pipette devices of the same device, FIGS. 5 and 6 are illustrations of the optical measurement device of the same device, and FIG. 7 is an illustration of the bead table of the same device. . X... Automatic analyzer 1... Sample container for general samples 2... Dilution tube 3... Sample container for emergency samples 4... Sample table 5... Reaction tube 6... Reaction table 7 ...First reagent table 8...Second reagent table 9...Sampling pipette device 10...First reagent bottle 11...First reagent pipette device 12...Second reagent bottle 13...・Second reagent pipette device 14...Optical measurement device 15...Fluorescence detection device Applicant Nippon Techtron Co., Ltd. Figure 4 Figure 11, 13 Figure 7 Figure 5 Figure 6 Procedure amendment (frog) 1986 November 28th, Commissioner of the Patent Office, Kuro 1) Mr. Akihiro ■ Paste 1, Indication of the case 1986 Patent Application No. 838!11 2, Name of the invention Automatic analysis device 3, Relationship with the amendment person case Patent Applicant Address: 4-8-5 Nakano Kamimachi, Hachioji City, Tokyo @Mr.
Name: Nippon Techtron Co., Ltd. Representative Tominaga
Public road 4, agent 〒103 6, subject of amendment

Claims (1)

[Claims] A turret-shaped sample table that holds a plurality of sample containers for general specimens on the outer periphery, holds dilution tubes in the same number as the sample containers for general specimens on the intermediate periphery, and holds sample containers for emergency specimens on the inner periphery. , a reaction table holding a required number of reaction tubes arranged concentrically on the outer circumferential side of the sample table so as to be able to rotate forward and backward, and a first reagent table and a second reagent table respectively arranged near the reaction table. a second reagent table; a sampling pipette device placed adjacent to the reaction table for selectively dispensing the sample or diluted sample in the sample container into a reaction tube or dilution tube; and a sampling pipette device placed on the first reagent table. a first reagent pipette device placed between the reaction table and the first reagent table for dispensing a required amount of the first reagent in the reagent bottle into the reaction tube; and a first reagent pipette device placed on the second reagent table. a second reagent pipette device disposed between the reaction table and the second reagent table for dispensing a required amount of the second reagent or third reagent in the reagent bottle into the reaction tube; An optical measuring device for performing colorimetric measurements and placed in the middle section consisting of a reaction table, a first reagent table, and a second reagent table; an electrolyte analyzer having a sampling pot in the movement path of the sampling pipette device; An automatic analyzer characterized by comprising a fluorescence analyzer placed nearby.