JPS62232569A - Automatic analyser - Google Patents

Abstract

PURPOSE:To rapidly and simply perform each operation, reaction operation and optical measurement, by a method wherein principal parts used in analytical operation on the basis of a predetermined sequence are arranged in close vicinity to each other and cooperated in connection with each other. CONSTITUTION:When a sampling table 4 is rotated and a predetermined specimen container 1 reaches a sample sucking position (a), the specimen in the container 1 is injected in the reaction tube 5 in parts corresponding to an emitting position (b) by a sampling pipet device 9. When the specimen in a specimen container 3 for an emergency specimen, said specimen is similarly injected in the reaction tube 5 in parts. Subsequently, the reagents of the reagent bottles 10, 12 of reagent tables 7, 8 are portionwise injected in the container 5 through reagent pipets 11, 13. The reaction liquid in each tube 5 is subjected to colorimetric measurement, fluorescent analysis, electrolyte analysis and oxygen immunoassay in an optical measuring apparatus 14, a fluorescent detector 15, an electrode side measuring device 18 and a bead table 16. The reaction tube 5 after the finish of measuring operation is washed by a reaction tube washing apparatus 19.

Description

[Detailed Description of the Invention] [Industrial Application Field 1] The present invention relates to an automatic analyzer, and in particular, it can be used for biochemical analysis, electrolyte analysis, blood drug concentration measurement, and immunological analysis using the same device. The present invention relates to an automatic analyzer capable of performing multi-purpose and multi-item measurements that can perform high-accuracy, high-speed analysis.

[Prior Art] Various automatic analyzers of this type have been proposed in the past, and biochemical analyzes and the like are performed using simple and miniaturized devices.

For example, a sample table holding a required number of sample containers and dilution tubes, a rotatable reaction table on the outer circumference of the table, and a first reagent table and a second reagent table near the reaction table. a sampling pipette device for selectively dispensing a sample or diluted sample into a reaction tube or a dilution tube, a first reagent pipette device and a second reagent pipette for dispensing a first reagent and a second reagent into the reaction tubes respectively; Each device was placed near the reaction table, and colorimetric measurements were performed using an optical measuring device. In this way, biochemical analysis and the like can be performed using the automatic analyzer. (For example, see Japanese Patent Application No. 139553/1983.) An automatic analyzer uses a large number of samples, various types of reagents, and a large number of reaction tubes to handle a large number of measurement items. There are demands for speed, accuracy, simplicity of the device, etc.

[Problems to be Solved by the Invention] However, the above-mentioned conventional automatic analyzers disclosed in, for example, Japanese Patent Application No. 139553/1980, cannot quickly carry out operations for sampling large quantities, dispensing reagents, and reaction operations. Moreover, there was a problem in that it could not be done easily. In addition, there is a problem in that the structure of the optical measuring device becomes complicated, such as requiring a correction device for the difference in light amount between the filters.

The present invention solves these conventional problems,
Sampling and reagent dispensing operations, reaction operations, and optical measurements can be performed quickly and easily for a large number of samples, and can be used not only for biochemical analysis and electrolyte analysis but also for blood drug analysis. The object of the present invention is to provide an excellent automatic analyzer that can perform concentration measurement and immunological analysis with high precision and high speed using the same device, and can perform multi-purpose and multi-item measurements.

[Means for Solving the Problems] In order to achieve the above object, the present invention holds a plurality of sample containers for general specimens on the outer periphery and has the same number of dilution tubes as the sample containers for general specimens on the intermediate periphery. A turret-shaped sample table that holds a sample container for an emergency specimen on its inner periphery, and a required number of reaction tubes arranged concentrically on the outer periphery of the sample table so as to be rotatable in forward and reverse directions are held. a reaction table, a first reagent table and a second reagent table respectively arranged near the reaction table, and the reaction table for selectively dispensing the specimen or diluted specimen in the sample container into the reaction tube or dilution tube. a sampling pipette device disposed adjacent to the table; and a system between the reaction table and the first reagent table for dispensing a required amount of the first reagent in the reagent bottle placed on the first reagent table into the reaction tube. a first reagent pipetting device disposed between;
A second reagent pipette disposed between the reaction table and the second reagent table for dispensing a required amount of the second or third reagent in the reagent bottle placed on the second reagent table into the reaction tube. an optical measurement device that performs colorimetric measurement of the reaction solution in the reaction tube and is provided with an optical path selection means disposed in the middle of the reaction table, the first reagent table, and the second reagent table; and the movement path of the sampling pipette device. an electrolyte analyzer equipped with a sampling pot, a fluorescence analyzer located near the reaction table, and an enzyme immunometer located adjacent to the reaction table between the fluorescence analyzer and a second reagent pipette device. It is equipped with a bead table for measurement.

[Function] The present invention has the following effects due to the above configuration. In other words, the sampling pipette device operates and the pipette nozzle at one end aspirates the required amount of sample from the sample container, then dispenses it into the reaction tube, and at the same time, the pipette nozzle at the other end is cleaned internally and externally. be done. Subsequently, the above-described sampling operation corresponding to the measurement item of the specimen is repeated. On the other hand, for a certain measurement item, the sample is diluted at a predetermined ratio as a diluted sample, and after the sampling pipette device is activated and the required amount of diluted sample is aspirated from the dilution tube, it is dispensed into the reaction tube. Ru.

The types of specimens are classified into general specimens and emergency specimens, depending on the degree of urgency of the clinical test, and emergency specimens are sampled with priority over general specimens. Next, when the first reagent bottle and second reagent bottle table corresponding to the measurement item arrive at the predetermined reagent suction position, the pipette nozzle at one end of the first reagent pipette device and the pipette nozzle at one end of the second reagent pipette device respectively After the first reagent and the second reagent are actuated and measured by suction, they are injected into the reaction tube. At about the same time, the pipette nozzle at each other end is cleaned internally and externally. The reaction solution dispensed into these reaction tubes is stirred by the movement of air bubbles generated by introducing air into the reaction tubes, thereby performing an operation for uniformizing and promoting the reaction. In the optical measurement device, the measurement light enters the light guiding hole of the reaction table and passes through the reaction liquid in the reaction tube, is separated by a concave diffraction grating, and is measured using a photodiode element, etc., and is then measured by a microcomputer. Concentration calculations are performed. As mentioned above, multiple sets of sample containers and dilution tubes for general samples and emergency samples can be held, and operations for reagent dispensing and reaction operations can be performed very quickly and easily according to a predetermined sequence. be able to.

[Example] Embodiments of the present invention will be described below with reference to the drawings.

1 and 2 show the configuration of an embodiment of the present invention. In Figure 1.2, X represents an automatic analyzer;
Reference numeral 4 designates a turret-shaped sample table, 6 a reaction table placed on the outer peripheral side of the sample table 4, 7 a first reagent table placed near the reaction table 6, and 8 a second reagent table. Further, 9 is a sampling pipette device, 11 is a first reagent pipette device, and 13 is a second reagent pipette device, all of which are arranged adjacent to the reaction table 6. Reference numeral 14 denotes an optical measuring device disposed at an intermediate portion between the first reagent table 7 and the second reagent table 8. On the sample table 4, a plurality of sample containers 1 for general specimens are arranged on the outer periphery, then the same number of dilution tubes 2 are arranged on the middle periphery, and further sample containers 3 for emergency specimens are arranged concentrically on the inner periphery. A large number of each is maintained. The sample containers 1 and 3 contain the required amount of specimen (serum, urine, etc.) collected from the living body to be measured, and the dilution tube 2 contains diluted specimens obtained by diluting the specimen at a predetermined ratio. be accommodated. The turret-shaped sample table 4, reaction table 6, first reagent table 7, and second reagent table 8 are controlled to freely rotate in forward and reverse directions according to a predetermined sequence using drive devices 41, 61, 71, and 81, respectively. .

When the sample table 4 is rotationally driven by the drive device 41 and a predetermined sample container 1 reaches a predetermined sample suction position a, the sample in the sample container 1 is passed through the pipette nozzle 105 at one end of the sampling pipette device 9. After the required amount is aspirated, it is dispensed into the corresponding reaction tube 5 at the sample discharge position. When the sample in a predetermined sample container 3 is used, the sample table 4 is rotated and transferred to a predetermined sample suction position a' as shown in FIG. 104 moves and the pipette nozzle 105 at one end aspirates a required amount of the sample in the sample container 3, after which the sample is dispensed into the corresponding reaction tube 5 at the sample discharge position shown in FIG.

Roughly speaking, when storing a diluted specimen obtained by diluting the specimen in the sample container 1 or sample container 3 at a required ratio into the dilution tube 2, the holder 104 of the sampling pipette device moves in the same manner as described above. Pipette nozzle 1 at one end
05 aspirates the specimen in the sample container 1 or the sample container 3, and then injects it into the dilution tube 2 as a diluted specimen.

Note that the diluted sample is transferred from the dilution tube 2 to the corresponding reaction tube 5 (
When dispensing, the liquid is dispensed via the pipette nozzle 105 at one end of the numbering pipette device 9 in accordance with the above-described operation.

Next, the first reagent table 7 and the second reagent table 8
, a plurality of first reagent bottles 10 and a plurality of second reagent bottles 12 used for the reaction are placed respectively, and when the reaction tube 5 into which the first sample has been dispensed comes to the first reagent discharge position f, the first reagent bottle 10 and the second reagent bottle 12 used for the reaction are placed. The reagent table 7 rotates and transfers the first reagent bottle 10 corresponding to the measurement item to the first reagent suction position d, and the first reagent is pipetted from inside the first reagent bottle 10 via the first reagent pipette device 11 to the pipette nozzle. 39, and the first reagent pipette is transferred to the first reagent discharge position f (the required amount is dispensed into the reaction tube 5.Next, when the reaction table 6 is fed two pitches, the first reagent pipette nozzle Air is sent by a stirring pump (not shown) to the stirring nozzle 41 arranged in parallel adjacent to the reaction tube 39, and the reaction liquid in the reaction tube 5 is stirred.

Roughly speaking, the reaction tubes 5 are transferred at a required pitch, and when they reach the second reagent discharge position q, the second reagent table 8 rotates and transfers the reagent bottles 12 corresponding to the measurement item to the second reagent suction position e, and A required amount of the second reagent is sucked into the pipette nozzle 40 from inside the reagent bottle 12 via the second reagent pipette device 13 C, and the second reagent pipette is transferred to the second reagent discharge position q, where the required amount is transferred into the reaction tube 5. be noted. Subsequently, when two pitches of the reaction table 6 are fed, air is sent by a stirring pump (not shown) to the stirring nozzle 42 arranged in parallel with the second reagent pipette, and the reaction liquid in the reaction tube 5 is stirred. The stirring positions of the reaction solution using the first reagent and the second reagent in 6 are respectively indicated by i.

The reaction solution in the above is sufficiently stirred by introducing air to generate bubbles and move the bubbles.
This is done to make the reaction uniform and promote it, and the stirring can be performed on the reaction table 6 without the reaction tube 5 itself being moved outside the apparatus.

The optical measuring device 14 uses a multi-wavelength photometer, and the first
As shown in the figure and FIG. 2, the light from the light source lamp 141 passes through the condenser lens 142, and
The measurement light that enters the light guide hole 63 and passes through the reaction solution in the reaction tube 5 is separated by an anti-tJA mirror 143 through a slit 144 and a concave diffraction grating 145, and a plurality of light receiving elements 146 change the current of each wavelength. The concentration is calculated by a microcomputer via an amplifier and an AD converter.

In the optical measurement, the absorbance at each measurement wavelength of each reaction tube is measured every time the reaction table 6 rotates one rotation and one pitch. Therefore, the absorbance can be measured at each step up to the first nozzle position J of the reaction tube cleaning device 19 after stirring the second reagent, and the time course of the reaction can be obtained. Measurements can be made. When this colorimetric measurement is completed, the reaction tube 5 reaches the first reaction tube cleaning position J, is cleaned by the reaction tube cleaning device 19, and is used again.

As mentioned above, since the optical measurement device 14 does not use a large number of filters that each convert to a different wavelength,
Not only can the device and operation for setting the optical path be omitted, but also the circuit for electrically correcting the difference in the light intensity of each filter can be omitted, making it possible to speed up measurement and simplify the structure. I can do it.

FIG. 3 is a detailed explanatory diagram of the sampling pipette device 9. The sampling pipette device 9 is composed of a holder 104 that holds a pipette nozzle 105 at each end, a vertical drive device 101 for the holder 104, a rotary drive device 102, and a telescopic drive device 103. The rotation axis 1 at both ends of
It is arranged at a symmetrical position of sample container 1.0B.
3 and the sample from dilution tube 2 and the reaction tube 5 for the diluted sample.
When transferring these samples to the reactor, the samples are suctioned and weighed using the sampling pump 21 shown in FIG. When the injection into the pipe 5 is completed, the flow path is changed by the solenoid valve 107, and the pipette nozzle 105 at the other end is connected to the sampling pump 2.
Cleaning is performed according to the remaining amount of extruded water in step 1. Thus, the sampling rate in the sampling operation can be significantly increased.

FIG. 4 is a detailed explanatory diagram of the first reagent pipette device 11 and the second reagent pipette device 13, and parts having common configuration will be described using the same reference numerals.

The first reagent pipette device 11 and the second reagent pipette device 13 include a holder 205 that holds pipette nozzles 39 and 40 at both ends, respectively, and a vertical drive device 2 for the holder 205.
01 and a rotational drive device 202, pipette nozzles 39.40 are arranged at both ends of the holder 205 at symmetrical positions with respect to the rotation axis 205, and stirring nozzles 41.42 are provided roughly. As mentioned above. First reagent bottle corresponding to the measurement item 10. When transferring the first reagent and second reagent from the second reagent bottle 12 to the reaction tube 5, these reagents are transferred to the first reagent pump 22 and second reagent pump 23 shown in FIG.
At the same time, the above-mentioned vertical drive device 201 and rotation drive device 202 are used to perform suction and metering, and when the injection into the reaction tube 5 is completed, the flow path is changed by the solenoid valve 203, and the pipette nozzle 39. 40 is cleaned by the remaining amount of water pumped out by the first reagent pump 22 and the second reagent pump 23. Thus, the reagent dispensing speed in the reagent dispensing operation can be significantly increased. Note that the measurement of the first reagent and the second reagent is performed by the first reagent pump 22,
Microsyringe in second reagent pump 23 (not shown)
The container is filled with water, and suction measurement is performed with the reagent and water separated through air. In addition, although not shown, the pipette nozzles 39 and 40 are equipped with liquid level sensors, so that the pipette nozzles 39 and 40 can be adjusted by changing the vertical movement stroke.
This prevents the outside of the 0 from getting wet with the reagent more than necessary.

As mentioned above, the sampling pipette device 9, the first reagent pipette I~ device 11, and the second reagent pipette device 13 are each provided with pipette nozzles at both ends, and the pipette nozzle at one end is used to aspirate and dispense. At the same time, since the pipette nozzle at the other end is cleaned at the same time, operations for sampling and reagent dispensing can be significantly speeded up.

When performing biochemical analysis using automatic analyzer X,
It is also possible to use the second reagent table 8 for the first or third reagent. In this case, reaction table 6 is
After dispensing the sample, rotate the required steps to the second reagent discharge position q
After dispensing the first reagent in the second reagent table 8, the operation of returning to the original position +1 is repeated. Similarly, the third reagent can be dispensed by rotating the reaction table 6 in forward and reverse directions.

Next, the case where electrolyte analysis is performed using automatic analyzer X will be described. An electrolyte sampling pot is installed near the reaction table 6 and at a position C along the movement path of the sampling pipette device 9.

Electrolyte analysis can be performed in parallel with biochemical analysis;
By discharging the sample to be dispensed into the reaction tube 5 into the electrolyte sampling pot Ha, the electrode measuring device 18 automatically measures the sample, and the data is sent to the microcomputer 34 and printed together with the results of the biochemical analysis.

In addition, a case will be described in which blood drug concentration is measured using the automatic analyzer X. A fluorescence analysis bag @15 is provided near the reaction table 6. This initial operation is almost the same as that for biochemical analysis, but since fluorescence measurement cannot be performed while the reaction table 6 is rotating, the fluorescence measurement is performed after the rotation is stopped. Therefore, although the reaction time course cannot be displayed, highly sensitive fine ff1f1 degree measurement can be performed.

The fluorescence analyzer 15 is mainly used for precise measurement of blood drug concentration, and is connected to an interference filter (for excitation light) from a light source.
Light passing through the reaction tube 5 (e.g. 485 nm) is applied to the reaction tube 5, and fluorescence proportional to the drug concentration is filtered through an interference filter (e.g. 5°25 nm).
nm) is applied to a light receiving element, converted into digital data by an amplifier/AD converter, and then calculated by a microcomputer.

In FIG. 1, reference numeral 19 indicates a reaction tube cleaning device, which is disposed near the reaction table 6 between the sampling pipette device 9 and the bead cleaning/discarding device 17, and is placed on the reaction table 6 after the measurement operation. When the placed reaction tube 5 reaches the washing position J, the washing pump device 24 discharges the washing liquid into the reaction tube 5 and suctions it to wash it, and discharges the waste liquid out of the system. The cleaning operation is carried out in eight stages, with alkaline detergent being injected into the second stage, acidic detergent being injected into the fourth stage, and pure water being injected into the other lines to ensure sufficient cleaning.

Furthermore, a case will be described in which enzyme immunoassay (EIA) using the automatic analyzer X is performed using beads in the same phase. 1st
In the figure, 16 indicates a bead table, and 17 indicates a bead washing/discarding device, which are arranged on both sides of the fluorescence analysis bag @15 in the vicinity of the reaction table 6. FIG. 7 is a detailed explanatory diagram of the bead solid-phase EIA measuring device. 1 and 7, the bead table 16 is used when performing bead solid-phase EIA, and the bead table 16 includes a plurality of bead stockers 25 storing EIA beads 404 corresponding to measurement items.
The bead table 16 is rotated by a rotary drive device 403, and the bead stocker 25 corresponding to the measurement item is rotationally transferred to the bead drop position k. The bead stocker 25 is equipped with a lever 405 for dropping beads 404 one by one, and the electromagnetic solenoid 4
06 into the reaction tube 5 according to the measurement item 404
can be dropped one by one. The bead washing/discarding device 17 is used when performing bead solid-phase EIA, and is composed of a vertical drive device (not shown), a rotation drive device, a bead washing nozzle, and a bead suction nozzle. Wash the beads and discard the beads after measurement.

FIGS. 5 and 6 show an optical measuring device used for bead solid-phase EIA measurements.

The operation in bead solid-phase EIA measurement will be briefly described.

The reaction tube 5 into which the beads have been inserted is rotated and transferred to a sample dispensing position by the rotation of the reaction table 6, and the sample is dispensed by the sampling pipette device 9. After the required time has elapsed, the first reagent is dispensed from the first reagent pipette 1 to the device 11, and stirred through two steps. After the required time has elapsed, the reaction tube 5 is transferred to the cleaning/discarding position of the bead cleaning/discarding device 17, and a cleaning liquid is discharged and sucked into the reaction tube to perform bead cleaning. Next, the reaction tube 5 is rotated to the second reagent discharge position, and the second reagent is dispensed by the second reagent pipette device 13. After the required time has passed, the first reagent 5 is again bead washed/
It is cleaned in a disposal device 7. Next, the third reagent on the second reagent table 8 is dispensed in the same manner, and after the required time has elapsed, it is measured by the optical measuring device 14.

After the measurement, the used beads are suctioned and discarded from the reaction tube 5 by the waste nozzle of the bead cleaning/disposal device 17. Finally, the used reaction tube 5 is cleaned by the reaction tube cleaning device 19 and can be used again. It is offered.

FIGS. 5 and 6 show an optical measuring device 14 used for bead solid-phase EIA measurements. The optical measurement device 14 is attached with an optical path selection device 30B, and is capable of measurement for both normal biochemical analysis and bead solid phase EIA. The optical path selection device 308 is composed of a beam correction lens 306, four total reflection mirrors 307, and a vertical drive device 309, and is positioned at the bottom for normal measurement, and the light from the light source lamp 141 passes through the condenser lens 142. The measurement is then carried out by a multi-wavelength photometer Y after passing through a reaction tube 5 containing the liquid to be measured. Bead in-phase EIA measurements are performed using the vertical drive device 309.
Optical path selection device 3 so that the light beam passes above beads 404
0B is positioned above and optical measurements are taken avoiding the beads. The optical path selection device 308 has the advantage that it can perform measurements with a small amount of reaction liquid in normal measurements, and can also perform measurements for bead in-phase EIA using the same multi-wavelength photometer.

Then, according to the predetermined sequence described in the examples,
The opening operation described above is performed using a control device.

In FIG. 1, the control device of the automatic analyzer
2, a microcomputer 33, and an operation panel 34,
It is composed of a personal computer 42 for data processing. Further, the personal computer 42 includes a CPU, a keyboard 35, a CRT display device 36, a magnetic disk storage device 37, and a printer 38 for printing measurement results. The magnetic disk storage device 37 stores required data such as measurement request items for clinical tests.

The temperature control device 31 is used to keep the reaction temperature of the reaction tube 5 constant and also controls the first and second reagent tables 7.8.
The temperature is controlled to be maintained at approximately 10'C using cold air to prevent deterioration of the reagents.

It goes without saying that the embodiment/II aspect of the invention of this application is not limited to the above-mentioned embodiments.

[Effects of the Invention] As is clear from the above embodiments, the present invention can be used for automatic analysis using a large number of samples, various types of reagents, and a large number of reaction tubes, etc., and corresponding to a large number of measurement items. It has the advantage of speed, accuracy, and simplicity of the device. Based on a predetermined sequence, the main parts used for analysis operations are placed close to each other and their operations are interconnected, allowing the transfer of samples, reagents, etc. over short distances. The analysis can be carried out in a short time, and compared to conventional automatic analyzers, the apparatus can be made more compact, and the speed and analytical ability can be significantly improved.

Since the sampling pot for electrolytic analysis is provided at a position on the movement path of the sampling pipette device, a separate sampling pipette device is not required, and the device can be simplified.

In addition, since the present invention is equipped with an optical measurement device equipped with an optical path selection means, it is possible to easily perform biochemical analysis or enzyme immunoassay without using a special optical measurement device for bead in-phase EIA. can.

In general, the present invention has devices for not only biochemical analysis but also electrolyte analysis, blood drug concentration measurement, fluorescence analysis, and enzyme immunoassay (EIA) using bead solid phase, which have the same configuration. It has great effects, such as being able to perform continuous sample analysis at high speed and with high precision for the above-mentioned automatic analysis.

[Brief explanation of drawings]

FIG. 1 is a plan view of an automatic analyzer according to an embodiment of the present invention, FIG. 2 is a sectional view of the same device in FIG. 1, FIG. 3 is a schematic explanatory diagram of the sampling pipette device of the same device, and FIG. The figure is a schematic illustration of the first and second reagent pipette devices of the same device, FIGS. 5 and 6 are illustrations of the optical measurement device of the same device, and FIG. 7 is an illustration of the bead table of the same device. . X... Automatic analyzer 1... Sample container for general samples 2... Dilution tube 3... Sample container for emergency samples 4... Sample table 5... Reaction tube 6... Reaction table 7 ...First reagent table 8...Second reagent table 9...Sampling pipette device 10...First reagent bottle 11...First reagent pipette device 12...Second reagent bottle 13... -Second reagent pipette device 14...Optical measurement device 15...Fluorescence detection device 16...Bead table 17...Bead cleaning/disposal device 18...Electrode side measurement device 19...Reaction tube cleaning Equipment Figure 4 11, 13 Figure 7 Figure 6 Procedure Ner11 Positive Dry (voluntary) November 1988
28th of the month, 4. □, 6, □, □ヮ Audience 1. Indication of the case 1986 Patent Application No. 76122 2. Name of the invention Automatic analyzer 3. Relationship with the amendment person case Patent applicant address Hachioji City, Tokyo Nakano Kamimachi 4-chome 8-5 @ Name: Nippon Techtron Co., Ltd. Representative Tominaga Komichi

Claims (1)

[Claims] A turret-shaped sample table that holds a plurality of sample containers for general specimens on the outer periphery, holds the same number of dilution tubes as the sample containers for general specimens on the middle periphery, and holds sample containers for emergency specimens on the inner periphery. , a reaction table holding a required number of reaction tubes arranged concentrically on the outer circumferential side of the sample table so as to be able to rotate forward and backward, and a first reagent table and a second reagent table respectively arranged near the reaction table. a second reagent table; a sampling pipette device placed adjacent to the reaction table for selectively dispensing the sample or diluted sample in the sample container into a reaction tube or dilution tube; and a sampling pipette device placed on the first reagent table. a first reagent pipette device placed between the reaction table and the first reagent table for dispensing a required amount of the first reagent in the reagent bottle into the reaction tube; and a first reagent pipette device placed on the second reagent table. a second reagent pipette device disposed between the reaction table and the second reagent table for dispensing a required amount of the second reagent or third reagent in the reagent bottle into the reaction tube; An optical measurement device that performs colorimetric measurements and has an optical path selection means placed in the middle of a reaction table, a first reagent table, and a second reagent table, and an electrolyte analyzer that has a sampling pot in the movement path of a sampling pipette device. and a fluorescence analyzer disposed near the reaction table, and a bead table for enzyme immunoassay disposed adjacent to the reaction table between the fluorescence analyzer and a second reagent pipette device. An automatic analyzer characterized by: