JPS5827608A - Body liquid filter - Google Patents

Abstract

PURPOSE:To reduce the damage of a blood corpuscle at the surface of a membrane even if a microporous membrane is used, by supporting a filter membrane by a flow passage regulating plate having protrusions with a specific dimension provided at specific intervals. CONSTITUTION:This body liquid filter has such a structure that a filter membrane 2, a body liquid flow passage regulating plate 3 and a filtrate flow passage forming plate 4 are laminated to be accomodated in a housing. As the filter membrane 2, a flat microporous membrane having a pore size of about 0.05-1mu is effectively used. The body liquid flow passage regulating plate 3 formes flow passage between this plate and the filter membrane 2 and plural protrusions 35 are formed on the surface thereof. The height (h) of the protrusions is adjusted to 50-250mu and the distance therebetween is set to 100-1,500mu. By providing this dimension and the distance, the thickness of the flow passage can be adjusted in good preciseness and a filtering amount corresponding to the area of the membrane is obtained while the filter membrane can be economically used and the damage amount of a blood corpuscle can be reduced more efficiently.

Description

DETAILED DESCRIPTION OF THE INVENTION ■ Background of the Invention Technical Field The present invention relates to a body fluid FJI device. For more details, please refer to the flat plate-shaped microporous membrane or the company's extra membrane! l! The present invention relates to a body fluid filter that handles the body fluids of LII and is used as a blood septic separator, a filtration type artificial front, etc.

B. Prior Art In such a body fluid filter, body fluids such as blood are allowed to flow through a flat filtration membrane almost parallel to the 1XWii, and the blood, etc. is filtered. In such a case, if the thickness of the flow path for blood or the like is made thinner, the pressure loss of the blood flow will be reduced, the shear rate of the blood flow will be increased, the amount of filtration will be increased, and the filtration efficiency will be improved.

However, in conventional body fluid filters, the flow path thickness of the in-fluid flow can be controlled by interposing a backing member thickener between the end of the filtration layer and the container wall or the laminated filtration membrane. Therefore, the P,4 membrane is deformed and becomes thinner, so if the thickness of the flow path is made thin especially for blood etc., the thickness of the flow path will not be uniform within the flow path, and the thickness of the flow path will not be uniform within the flow path. When the fluid flow path and the v-liquid flow path are layered, the thickness of the flow path for blood or the like becomes non-uniform between the flow paths. For this reason, the amount of filtration varies,
*m, prevents blood coagulation. In addition, even if the membrane area is increased and the flow channels are layered in order to increase the processing efficiency of filtration, unbalanced fi (channeling) occurs within the flow channels and between the channels, and the efficiency that matches the increase in the membrane area increases. cannot be improved. In addition, when a microporous membrane is used as a filtration membrane and blood is filtered, minerals,
This channeling causes damage to the JLL sphere between the membranes.

In view of this actual situation, Book I! IT experts have previously proposed that a filtration membrane is provided with a large number of protrusions on its surface and supported by a corpse liquid flow path regulating plate. A body like this [filtration @
According to - it is possible to prevent deformation of the filtration membrane, to ensure a flow path for blood, etc. with a desired flow path thickness in the interval between the eastern part and the protrusion, to obtain the desired filtration amount, and to reduce the variation in filtration. small.

However, even when using such a body fluid flow path regulating plate, the
If a microporous membrane is used for this purpose, damage to blood cells such as hemolysis may be significant. In order to reduce the damage to blood cells, it is possible to increase the thickness of the channel, but if we try to reduce the amount of damage to blood cells to a level that is practically satisfactory, the amount of filtration will be insufficient, and the filtration efficiency will be reduced. This will cause a decline.

1. Purpose of the invention The present invention was made in view of the above circumstances, and
The first purpose is to improve the body fluid flow path regulating plate having the protrusions proposed above, to reduce the occurrence of channeling, and to provide an integrated fluid filter with higher filtration efficiency. be. The second object is to provide a body fluid filter that causes less damage to blood cells, especially when filtering blood, even when a large amount of filtration is performed.

The inventors of the present invention conducted extensive research for this purpose and found that the amount of channeling that occurs depends on the dimensions and spacing of the protrusions, and as a result of further research,
The present invention was achieved by finding the optimum dimensions and optimum spacing of the protrusions that minimize the occurrence of channeling. That is, the present invention includes a body fluid filtration membrane consisting of a flat plate-shaped microporous membrane or an ultrafiltration membrane, and a synthetic resin-made membrane provided on one side of the filtration membrane with convex portions formed at regular intervals on the surface. body fluid flow path regulating plate and a p liquid flow path forming plate provided on the other side of the filtration membrane and forming an F liquid flow path, these are connected to the body fluid inlet, the body tlLrIL outlet, and the p liquid flow path. The housing is housed in a housing having an outflow port, and the body fluid introduced from the body fluid inlet passes through the gap between the membrane and the body fluid flow path regulating plate, separates the P-tub, and then flows into the body fluid outflow port. In a body fluid F:iM device, a body fluid F:iM device is formed by forming a body fluid path leading to a fluid F:iM device, and a fluid path F through which the filtrate separated by the filtration membrane passes through the F fluid flow path forming plate to the fluid F outlet, The value obtained by subtracting the thickness of the filtration membrane from the height of the protrusion above is 50
~250μ, and the distance between the protrusions is 100~! ,
There is a body IP filter characterized by 600μ and 9.

Furthermore, the main object of the embodiments of the present invention is to provide a configuration that more effectively achieves the above object.

Examples of implementation of the present invention include the following.

1) The body fluid filter of the present invention, wherein the value obtained by dividing the square root of the area of the bottom of the protrusions by the interval between the protrusions is 0.3 to 1.

++) The body fluid filter according to the present invention or 1) above, wherein the area of the bottom of the protrusion is larger than the area of the top of the protrusion.

111) Young's modulus of the protrusion is 1.0X10' to 2X1
0”dyn /-Shore Aii of the protrusion
! Kien BA with a degree of 20 to 100 or 1) above
Or the body fluid filter described in 1i) above.

lv) The body fluid filter according to any one of 1) to 111) of the present invention, wherein the protrusions are formed on one or both sides of the blood flow path regulating plate.

V) Kinoe BA or the above i) to IV in which the filtration membrane consists of a microporous layer having an average pore diameter of 0.05 to 1μ
) The body fluid F1a device according to any one of the above. v1) Insert a body fluid flow path regulating plate with protrusions on both sides between the two filtration membranes, seal the gap between the two filtration membranes to prevent body fluid and p-liquid from mixing, and connect this with a mesh. The present invention or the body fluid filtration device according to 1) to 2) above, which is formed by laminating layers with F liquid flow path forming plates in the form of a shaped or porous body interposed therebetween.

ViD A mesh or porous p filter is placed between two filtration membranes.
The body fluid filter of the present invention or the above 1) to vl), in which a liquid flow path forming plate is inserted and body fluid and furnace fluid are mixed.

Vll+) At least one of the two upper and lower plate-like bodies constituting the housing is made slidable, and a filter membrane and body v1. The body fluid filter according to Kinoe 8A or any one of 1) to vll) above, which houses a flow-path regulating plate and a P-liquid flow-path forming plate, and is capable of suppressing the space between the two collapsing plate-like bodies from above and below. .

■Specific structure of the invention The present invention will be described in detail below with reference to Examples.

Embodiments of the present invention are shown in FIGS. 1-3.

In FIG. 1, the body fluid filter of the present invention includes a housing 1
Equipped with. In the illustrated example, the housing l includes a side plate 101 having a body fluid inlet 11, a side plate 102 having a body fluid outlet 12, and a side plate 101 having a body fluid outlet 151.
03, a side plate 104 having a V liquid outlet 152, an upper plate 105, and a lower plate 106.

The side plates 101 to 104, the upper plate 105, and the lower plate 106 are each made of hard plastic or the like in a rectangular shape. The side plates 101 to 104 are arranged so that the inside can be kept airtight.
Each has a through hole formed in the center of the surface, which has a body fluid inlet 11, a body fluid outlet 12, and a fluid outlet 15.
1, 152 is attached 0 In such a housing 1, a Pma2, a body fluid flow path regulating plate s, and an r* flow path forming plate 4 are housed in a stacked manner.

In this case, the filtration M2 is a flat membrane-like ultra-P:A filter or a microporous membrane.

The ultrafiltration membrane may be any membrane as long as it stops O blood cell components, proteins, etc. at about 30 to 100 A or more. Also,
Any microporous membrane may be used as long as it has a pore diameter of 1 fi or less and can efficiently separate blood cell components and blood plasma components.

However, according to the present invention, it is effective that the P:A membrane is a porous paper membrane of about 0.05 to 1 μm in terms of more significantly reducing damage to blood cells. As such microporous membranes, esters of cellulose such as cellulose butyrate, acetic acid cellulose, cellulose derivatives such as nitrocellulose, alkaline or polycarbonate), PMMA, etc.
, polyvinyl chloride, polyester, polyamide, polysulfo/, PVA, and other synthetic resins, generally having a thickness of 30 to 200 degrees and 8 degrees, and using known so-called phase separation methods, extraction methods, Any material in which fine pores are provided by a grinding method, a charged particle irradiation method, or the like is suitable.

The body 11 flow path regulating plate 3 forms a flow path for O body fluids such as blood in conjunction with the V overload 2, and is made of synthetic resin.
As shown in 12111, it has a flat plate shape, and a plurality of center portions 35 are formed on its surface.

In this case, the protrusion 35 may be formed only on one side or may be formed on a 9-sided plate, and the thickness of the plate, excluding the protrusion, is approximately 500 to 2,000. Ru.

The dimensions, arrangement, etc. of the protrusions 35 formed on the body fluid flow path regulating plate 3 are subject to the following limitations.

First, referring to FIG. 3, the height b of the protrusion 35 is 50 to 250μ. The reason for regulating the height h as the dimension of the protrusion is as follows.

That is, the body fluid flow path regulating plate 3 is usually made of elastic synthetic resin, and can compress the P filter to narrow the thickness of the body fluid flow path, and can also relax the pressure so that the flow path is reversible. It is preferable that it be restored to . Therefore, the channel thickness is changed by pressure, but if the height ht when not pressed is regulated, the channel thickness can be easily changed to 1tiIIl.
can.

In the present invention, the height h is thus in the range of 50 to 250μ. When the height h becomes smaller than 50μ, it becomes difficult to manufacture the protrusion 35 itself, the height of the protrusion varies, and it becomes difficult to precisely adjust the channel thickness. , the amount of channeling increases, causing problems such as increased blood cell damage, failure to obtain a V excess amount that meets the lxm product, and decreased filtration efficiency.

Furthermore, if h exceeds 150μ, an error in the channel thickness is likely to occur when an attempt is made to narrow the body fluid channel thickness by pressing. In addition, the amount of channeling increases, causing greater blood damage, and the amount of overdose decreases, resulting in a lower efficiency of overdose.

Further, the spacing between the protrusions s35, more specifically, the spacing between the centers of the tops of the protrusions (Fig. 383, d) Fi, is 100 to L5·OO.

When the interval d is less than 100 voices, the membrane area decreases and pressure loss increases, so the filtration membrane! ! In addition to being economically unusable, the amount of F-water decreases, and when blood is FAed, the damage to blood cells increases. On the other hand, the interval d! , when the number of voices exceeds 500, the amount of deformation of the bimembrane becomes large. jo, fij!
-The thickness varies and the amount of channeling increases, F:
When the amount of A is increased, blood cell damage becomes J[lI.

Furthermore, the shape of the base of one protrusion may be various shapes such as a cone, a pyramid, a cylinder, a prism, etc., but the square root of the base area is
It is preferable that the value divided by the distance d between the protrusions is 0.3 to 1. By doing so, the V excess amount under suppression at a constant pressure loss is increased, and the amount of blood cell damage at that time is further reduced.

Also, is the protrusion bottom sO area equal to the protrusion top SOW product?
Or preferably larger than that 0 protrusion top 5 oi
This is because when isi is made larger than that of the bottom of the protrusion, it becomes difficult to manufacture KFi, and the thickness of the OR path during compression tends to become non-uniform.

In addition, although it is preferable that the protrusion s35 has elasticity as described above, the Young's modulus of the protrusion, that is, the Young's modulus of the entire body fluid flow path regulating plate 3 is usually between 1X10 and 2X10.
” dyn/'s is preferable atxxO@ or 2
X I Qlod)'n /cj is preferably 0. In addition, the shore h*lnz of the projection s35, that is, the body fluid flow path regulating plate 3 is preferably 20 to 100.

Such synthetic ams with blowfish ratio and Shore A11I degree include Ll such as low density polyethylene, silicone rubber, isoprene rubber, butyl rubber, styrene-butadiene rubber (SBR), polytetrafluoroethylene (
PTFE), ethylene vinyl acetate^ polymer resin (EVA)
) etc.

In this range of Fugu modulus and surface hardness, Young's modulus and Shorem hardness are lXl0'd7n/a
j and less than 20, the ability to support the filtration membrane and prevent its deformation is improved, and 2 x 10
"Compared to the case where d7n/Cj is larger than 100 (for example, Borig tetrapyrene), the elastic deformation of the protrusion due to compression is much easier, and the amount of filtration can be increased. On the other hand, If the material is too soft, it will not be able to withstand the deformation stress of the filtration membrane, and if it is too hard, the channel thickness may not change due to pressure.

Note that, as shown in the second figure, the body fluid flow path regulating plate 3 does not have the protrusions 35 formed on both sides, but has the protrusions 3 only on one side.
5 may be formed. Moreover, when providing protrusions on both sides, a hard plate-like body may be inserted inside the protrusions for reinforcement.

Furthermore, as disclosed in the above-mentioned proposal, various aspects are available for laminating the body fluid flow path regulating plate 3, the above-mentioned filtration membrane 2, and the below-mentioned F liquid flow path forming plate 4. For example, the body fluid flow path regulating plate 3 may have a portion formed at its end to serve as a backing member for lamination. , screen mesh, etc., and has a mesh size of approximately 80 to 500.
μ, and the layer thickness is approximately 80 to 1.200 μ. Then, through this F liquid flow path forming plate 4, filtration Jl! It is filtered through I2 and the channel thickness of 9P1fL is determined. In this case, if the opening is too small, the flow path resistance will be large, making it difficult for the F liquid to flow, and conversely, if the opening is too large,
The filtration membrane is deformed, causing channeling, and hemolysis and coagulation.Furthermore, the Fil channel forming plate 4 may be formed into a porous body having pores similar to those described above, in addition to the mesh shape.

Furthermore, as illustrated in the previous proposal, this P'WL
The flow path forming plate 4 has the above-described solid filtration membrane 2, the body fluid flow path regulating plate 3, the F liquid flow path forming plate 4, and one surface of the filtration membrane 2 at the end thereof, if necessary. The body fluid flow path regulating plate 3 is brought into contact with one surface, and the F fluid flow path forming plate 4 is brought into contact with the other surface, and these are housed in the housing 1. In this case, in order to increase the membrane area, usually several V filters are stacked and each filter [
Each surface of 12 is the body ta path regulating plate 3 and the P liquid flow path forming plate 4! ! K to do so, and it is stored.

When these are housed in the housing l, the body fluid introduced from the body fluid inlet 11 of the housing l is filtered, After passing through the gap with the regulation plate 3 and separating the P liquid, there is a body fluid path leading to the body fluid outlet 12, and the F liquid separated by the filtration membrane 2 passes through the F liquid flow path forming plate 4 to form the V liquid flow. Exit 15
It is important that the filtrate path is formed to reach 1.152.

, if you configure it like this, it will be very similar to mine, if
4 is as disclosed in the above-mentioned earlier proposal.

However, since the structure is much simpler, for example, as shown in FIGS. 1 and 2, the body fluid flow path regulating plate 30
The above-mentioned protrusions 35 are formed on both sides, and these are inserted between the two filtration membranes 2.2, and the two filtration membranes 1 [2, 2, for example, tfF liquid Outlet 151,1
5211 end portions are sealed, and these are laminated with, for example, a mesh-like ν liquid flow path forming plate 4 interposed therebetween, and further, the twill portion and body fluid outlet and inlet ports 151 and 152 @ end faces of the laminate are sealed with, for example, an adhesive 5. The upper plate 105 and the lower plate 10 are sealed using a sealing material or a wire heat seal.
6 and housed in the housing IP3. When the body fluid such as blood is passed through the body fluid inlet 11, the body fluid flow path regulating plate 3 between the filtration membrane turtle 2 is configured as shown in FIG.
(passes within the interval of the protrusions 35) and reaches the body fluid outlet. Maku,
The tPtIiL is discharged from the rPI liquid flow channel type tube 4 and the F liquid outlet 151 and 152.

Another embodiment of the invention is shown in FIGS. 4 and 5.

In the same figure, the housing 1 has a body fluid inlet 11 and a body @
A cylindrical case 1 having an outlet 12 at the bottom and sealed at the lower end.
08 and an upper plate 109 having P liquid outlets 151 and 152.
are connected to each other via an O-ring 17, and a v filter 2, a body fluid flow path regulating plate 3, and an F liquid flow path forming plate 4 are housed in a stacked manner in this housing 1.

In this case, the body fluid flow path regulating plate 3 has protrusions 3 on both sides inside and outside.
5. Then, the upper and lower filtration membranes A2 are arranged so as to sandwich the F liquid flow path forming plate 4, which is a mesh or porous material made of a screen mesh or the like, and the periphery of the filtration membrane A2 and the periphery of the center opening % 23 are sealed. In addition, a sealing material 55 is attached to the outer periphery of the p-liquid passage holes 251 and 252.

Body fluid flow path regulating plates 3 are disposed above and below this filtration membrane 2.2, and are integrally joined to the filtration M2.2 with a sealing material 55, and these are stacked as shown in the figure. It is housed in housing 1.

Even in such a case, the structure is extremely simple. 0 ■ Specific effects of the invention The body fluid evaporator of the present invention removes blood, blood, etc. from the human body or blood or body fluid container by the action of a pump or the like. body fluids are discharged and flowed into the filter, which is used as a blood separator or a diaphragm-type artificial kidney.

In this case, body fluid such as blood flows in from the body fluid inlet 11, passes between the filtration membrane 2 and the body fluid flow path regulating plate 4, and collects molecules smaller than predetermined components such as blood cell components and protein components. The blood plasma component with its components is separated as a V fluid, and the remaining fluid is discharged through the body fluid outlet 12, added with a desired replacement fluid, and returned to the human body.

On the other hand, the V liquid passes through the F liquid flow path forming plate 4 and is discharged from the furnace liquid outlet, and is either discarded or purified and returned as a replacement liquid.

In such use, it is preferable to apply a pressing force to the flat plate filtration (perpendicular to the plane of 12, using a coil spring, screw, etc.) and adjust the pressure drop in the body fluid flow path as desired. .

According to the present invention, by overlapping the filtration M2 and the body fluid flow path regulating plate 3 having a large number of protrusions 35 to form a body fluid flow path, deformation of the filtration membrane 2 is extremely small. A uniform flow path for body fluid is formed in the gap between the protrusions 35.

Furthermore, by changing the pressing force, the thickness of the body fluid flow path can be varied, and this can be precisely controlled on the order of tens of microns using the expansion force loss as an index.

As a result of regulating the dimensions and arrangement of the protrusions 35 in a predetermined manner, channeling is significantly reduced, the amount of filtration is significantly increased, the amount of permeation commensurate with the membrane area is obtained, and the filtration efficiency is significantly increased. In addition, during blood filtration, damage to blood cells such as hemolysis is significantly reduced, and the filtration efficiency or membrane agent rate is extremely high.

In this case, according to the above-mentioned embodiment 1) or ii), such an effect becomes even better when the ratio between the dimension of the bottom of the protrusion and the interval between the protrusions and the shape of the protrusion are regulated to a predetermined value. Become.

Further, according to the above embodiment 111), if the Young's modulus and the Table III hardness of the protrusion are set within a predetermined range, the thickness of the body fluid flow path can be changed more precisely.

Further, according to the above-mentioned embodiment 1v), when the average pore diameter of the filtration membrane is 0.05 to 1 μ, such an effect becomes significantly more pronounced.

Further, as in the embodiment 111), the body fluid flow path regulating plate 3 may have protrusions formed on either one side or both sides. According to the embodiment Vl) or Vll), the body fluid flow path regulating plate 3 or the F liquid flow path forming plate is sandwiched between the two filtration sheets M2 and laminated, resulting in an extremely simple structure and easy handling. It becomes easier.

Furthermore, by freely pressing the laminate according to the above-mentioned Aspect V), the thickness of the flow path can be changed using a simple control system using the pressure loss as an index. Various experiments were conducted to confirm the effects of the present invention. An example is shown below.

Experimental Example 111g In the apparatus shown in Figures 4 and 5, a microporous Mt-made cellulose acetate membrane having an average pore diameter of 0.45 μm and a membrane thickness as shown in Table 1 was used as the filtration membrane, and As a body fluid flow path regulating plate, the thickness is 0.
7 proverbial low density polyethylene (Young's modulus 2 x 10'
The body fluid filtration method of the present invention is made of dyn/cIls (Shore A hardness: 64) and has convex portions of height b, distance ad, and 4/d (S is the cross-sectional area of the bottom of the convex portion) as shown in Table 1. Filters A1 to A10 and filters A11 to A18 for comparison were prepared.

Also, for reference, the body fluid flow path regulating plate was replaced with a ring-shaped one having the thickness shown in Table 1, and filters 19 to 24 were made into circles.

Blood is passed through these filters AX~24 under the conditions shown in Table 2, and at that time the filters are pressed to obtain the pressure loss PD (mmHg) shown in Table 2, and the calculated flow path thickness at that time is bCa+], actual measurement of free hemoglobin (V'dAl and membrane efficiency).

In this case, the calculated flow path *b was determined from the following formula.

b"312QB ・fi ・Lt PD-@-g to ζ
, QB is the blood flow rate C11 minutes], μ is the blood viscosity, Gourd is the blood flow path length (a+), and gc is the gravity coefficient (5I/set")
It is.

In addition, the amount of mogbin released into blood plasma is expressed as the difference between the control value and the membrane efficiency.
It was determined from the ratio between the actually measured filtration amount Qr(2) (m/min) and the filtration amount QF(1) as the calculated value below.

QF(1) = I X (?)'X a X Lt
= 6Qn/ab" where I and J are coefficients determined experimentally depending on the p-layer film used, I = 1.4 x 10-', J =
0 which is 0.8 Also, t is the blood flow path length [country].

The effects of the present invention are clear from the results shown in Table 1.

[Brief explanation of the drawing]

FIG. 1 and FIG. 2 are diagrams showing embodiments of the present invention.
1 is an exploded perspective view, and FIG. 2 is an enlarged exploded perspective view of FIG. 1. FIG. 3 is an end view for explaining the present invention in detail. 4 and 5 are diagrams showing other embodiments of the present invention, of which FIG. 4 is an exploded perspective view and FIG. 5 is a sectional view. 1... Housing, 11... Body fluid inlet, 12...
・Body fluid outflow port, 151.152...p excess outflow port, 2.
... V membrane, 3... Body fluid flow path regulating plate, 35... Protrusion, 4... Ftfi tract forming plate Applicant Terumo Corporation Representative Patent Attorney Yo Ishii - Fang 2 Tsuri Fang 8 illustration tusk 4 illustration

Claims (1)

[Claims] 1. F'J exchange of bodily fluids consisting of a flat microporous membrane or an ultrafiltration membrane, and protrusions provided at regular intervals on one surface of the filtration membrane [, Table Wk] It consists of a body fluid flow path regulating plate made of synthetic resin and a filtrate flow path forming plate provided on the other side of the membrane to form a filtrate flow path, and these are connected to the body fluid inlet and body fluid flow path. The body fluid introduced from the body fluid inlet passes through the gap between the filtration membrane and the body fluid flow path regulating plate to separate the P fluid, and then the body fluid is A body fluid path leading to the outflow port, and a Fl'l! where the F fluid separated by the membrane passes through the filtrate flow path forming plate and reaches the filtrate outflow port. The height of the upper central part is 50 to 25 mm.
0 s, and the interval between the protrusions is 100-1,80
A body*filter characterized by having 0 μ. λ Body i [filter 03, area of the bottom of the protrusion] according to claim 1, wherein the value obtained by dividing the square root of the area of the bottom of the protrusion by the interval between the protrusions is 0.3 to 1. The body fluid filter according to claim 1 or 2, wherein the area is equal to or larger than the area of the top of the protrusion. 4. Young's modulus of the protrusion is 1.0X10' to 2X10''
It is dyn/cj, and the shore A hardness of the protrusion is 2.
0 to 100 of claims 1 to jI
The body fluid filter 05 according to any one of claims 3, the body fluid f according to any one of claims 1 to 4, wherein the center portion is formed on one piece W1 or both sides of the body fluid flow path regulating plate. Overage. 6. The body fluid filter according to any one of claims 1 to 5, wherein the filtration membrane is a microporous membrane having an average pore diameter of 0.05 to 1μ. A protrusion is formed in the cadaver fluid flow path regulating plate, and a seal is placed between the two F-A membranes so that the body fluid and Pli do not mix. A body fluid-transfer device according to any one of claims 1 to 6, which is laminated with forming plates interposed therebetween. & Insert a mesh or porous V liquid flow path forming plate between the two temporary membranes to prevent body fluid and F liquid from mixing.
A body fluid FM device according to claims 1 to 6, which is formed by sealing between two temporary membranes and stacking them with a body fluid flow path regulating plate having a central portion formed on both sides. . At least one of the upper and lower two plate-like bodies constituting the housing is slidable, and the KP filtration membrane body fluid flow path regulating plate and the p-liquid flow path forming plate are housed between the two plate-like bodies. 2
A body fluid evaporator according to any one of claims 1 to 8, wherein the space between the plate-shaped bodies can be suppressed from above and below.