JPS5767602A - Preparation of pullulan for expanding plasma - Google Patents

Preparation of pullulan for expanding plasma

Info

Publication number
JPS5767602A
JPS5767602A JP14295380A JP14295380A JPS5767602A JP S5767602 A JPS5767602 A JP S5767602A JP 14295380 A JP14295380 A JP 14295380A JP 14295380 A JP14295380 A JP 14295380A JP S5767602 A JPS5767602 A JP S5767602A
Authority
JP
Japan
Prior art keywords
pullulan
molecular weight
average molecular
weight
fraction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14295380A
Other languages
Japanese (ja)
Other versions
JPS6121481B2 (en
Inventor
Mikihiko Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hayashibara Seibutsu Kagaku Kenkyujo KK
Original Assignee
Hayashibara Seibutsu Kagaku Kenkyujo KK
Hayashibara Biochemical Laboratories Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hayashibara Seibutsu Kagaku Kenkyujo KK, Hayashibara Biochemical Laboratories Co Ltd filed Critical Hayashibara Seibutsu Kagaku Kenkyujo KK
Priority to JP14295380A priority Critical patent/JPS5767602A/en
Publication of JPS5767602A publication Critical patent/JPS5767602A/en
Publication of JPS6121481B2 publication Critical patent/JPS6121481B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To obtain a pullulan in high yield having a specific molecular weight useful as an plasma expander for preventing and remedying traumatic shocks caused by bleeding, excellent in safety, obtained by hydrolyzing a raw material pullulan partially, followed by fractionation.
CONSTITUTION: A raw material pullulan is partially hydrolyzed with an acid (lactic acid, etc.) or an enzyme (e.g., α-amylase, etc.), and fractionated with a hydrophilic organic solvent (e.g., methanol, etc.), to give a pullulan fraction, which is decolored with active carbon, etc. and desalted. The fraction is filtered by a membrane filter, concentrated of further dried, to give the desired pullulan having a ratio of weight-average molecular weight to number-average molecular weight of ≤1.5 and a weight-average molecular weight of 30,000W90,000.
COPYRIGHT: (C)1982,JPO&Japio
JP14295380A 1980-10-15 1980-10-15 Preparation of pullulan for expanding plasma Granted JPS5767602A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14295380A JPS5767602A (en) 1980-10-15 1980-10-15 Preparation of pullulan for expanding plasma

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14295380A JPS5767602A (en) 1980-10-15 1980-10-15 Preparation of pullulan for expanding plasma

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP15613481A Division JPS57141401A (en) 1981-10-02 1981-10-02 Production of pullulan with narrowed molecular weight distribution

Publications (2)

Publication Number Publication Date
JPS5767602A true JPS5767602A (en) 1982-04-24
JPS6121481B2 JPS6121481B2 (en) 1986-05-27

Family

ID=15327485

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14295380A Granted JPS5767602A (en) 1980-10-15 1980-10-15 Preparation of pullulan for expanding plasma

Country Status (1)

Country Link
JP (1) JPS5767602A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57141401A (en) * 1981-10-02 1982-09-01 Hayashibara Biochem Lab Inc Production of pullulan with narrowed molecular weight distribution
US5518902A (en) * 1992-08-20 1996-05-21 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo High pullulan content product, and its preparation and uses

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57141401A (en) * 1981-10-02 1982-09-01 Hayashibara Biochem Lab Inc Production of pullulan with narrowed molecular weight distribution
JPH0248561B2 (en) * 1981-10-02 1990-10-25 Hayashibara Seibutsu Kagaku Kenkyusho Kk
US5518902A (en) * 1992-08-20 1996-05-21 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo High pullulan content product, and its preparation and uses

Also Published As

Publication number Publication date
JPS6121481B2 (en) 1986-05-27

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