JPH10324624A - Bactericidal disinfectant composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition useful as a bactericidal disinfectant capable of suppressing skin drying (hand roughening) by mixing a lower alcohol using as a major component, a cationic bactericide, an amphipathic amide derivative and water. SOLUTION: This composition is prepared by mixing 30-95 wt.%, preferably 70-80 wt.%, of a lower alcohol (e.g. ethanol), 0.01-3.0 wt.%, preferably 0.05-0.3 wt.%, of a cationic bactericide (e.g. benzalkonium chloride bearing 8-18 C), 0.01-5.0 wt.%, preferably 0.1-1.0 wt.% of an amphipathic amide derivative a compound of the formula [R<1> and R<2> are each a 1-40 C (hydroxylated) hydrocarbon; R<3> is an 1-6 C alkylene or single bond; R<4> is H, an l-12 C alkoxy, etc., however, R<4> is H when R<3> is single bond]} and a water residual part.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for disinfecting a finger or the like containing a lower alcohol such as ethanol as a main component, and more particularly, to a disinfectant composition capable of suppressing skin dryness (roughness of the hand) due to a lower alcohol. Things.

[0002]

2. Description of the Related Art In hospitals, medical workers such as doctors and nurses, as well as hospitalized or outpatients, suffer from various infectious diseases. Pathogens are brought into hospitals by various routes and can cause nosocomial infections. In addition, the same infection may be caused not only in hospitals but also in home medical care. Such hospital-acquired infections can be prevented to some extent by such medical workers and patients by practicing sufficient hand washing, but it is difficult to completely eliminate the pathogenic bacteria by hand washing alone. Therefore, a quick-drying ethanol preparation containing ethanol for disinfection as a main component has recently been used.

That is, an ethanol preparation containing an appropriate disinfectant for disinfecting fingers is provided at a nurse station, a ward entrance, an ICU, each ward entrance, etc. of a hospital, and this ethanol preparation is prepared before and after treatment and care of a patient. Disinfection of fingers with preparations. This ethanol preparation can easily disinfect fingers by receiving an appropriate amount of antiseptic solution on the palm at the time of use and rubbing it, and it is quick-drying, so that wiping with a towel is unnecessary.

There are four types of finger disinfection: a basin method (immersion method), a swab method (wiping method), a scrub method (cleaning method), and a rubbing method (rubbing method). The basin method is a method of disinfecting a wash basin by applying a disinfectant solution thereto and immersing a finger in the disinfectant solution. The swab method removes contamination by wiping the skin surface with a cotton ball or gauze soaked with a disinfectant,
It is to be cleaned and disinfected. Ethanol for disinfection is often used as a disinfectant, and is used for skin disinfection at an operation site or an injection site. In this case, the disinfecting effect cannot be expected unless the disinfecting solution is sufficiently applied and the skin is in contact with the disinfecting solution for a certain period of time. The scrub method is hand washing under running water, and washing with water alone is effective but not perfect. If the washing time is short, bacteria indigenous to the skin come out of the pores, which may increase the number of bacteria. There is also a method of washing hands with a disinfectant containing a cleaning agent and water, but both have the drawback that they cannot be used without equipment because they require hand washing equipment. The rubbing method takes a quick-drying disinfectant in your palm,
This method disinfects the skin by rubbing it until it dries, and does not require water. The ethanol preparation is used for this rubbing method.

[0005] The ethanol preparation according to the present invention is used not only in hospitals for medical staff such as doctors and nurses, but also for inpatients or outpatients, as well as general use in homes such as nursing homes and home medical treatment sites. Disinfectant, and an ethanol preparation for hand disinfection that can be used everywhere, such as in food processing workers including restaurants and restaurants.

[0006] Generally, ethanol preparations include ethanol for local disinfection (76.9-81.4 v / v% aqueous ethanol solution).
Is used. However, if this pharmacological disinfectant ethanol is used frequently by healthcare workers in a day,
The sebum component, intercellular lipid component, NMF (natural moisturizing factor) component, etc. are eluted due to the permeation of ethanol into the skin, resulting in a decrease in the amount of water in the stratum corneum and a decrease in water retention capacity, resulting in rough hands (skin damage) Trigger. In addition, fingers that are in a rough state are more likely to adhere to bacteria and are more likely to cause secondary infection.

[0007] Therefore, as a means for suppressing hand roughness caused by ethanol for local disinfection, ethanol preparations containing a water-soluble humectant or an oil-soluble emollient for protecting the skin have already been marketed. Such an ethanol preparation suppresses hand roughness due to a water-soluble humectant or an oil-soluble emollient remaining on the skin surface. Medical workers at medical institutions and home medical sites are expected to engage in various tasks after disinfecting their hands with ethanol preparations. Therefore, when adding the water-soluble humectant or emollient, it is necessary to prevent the work from being hindered by stickiness of the fingers. In addition, when engaging in various operations, there is a physical load such as rubbing due to water washing such as hand washing, use of medical equipment, and contact with clothing. Therefore, from the viewpoint of suppressing hand roughness, it is necessary to maintain the moisturizing effect, to be excellent in water resistance and friction resistance even after being used for fingers, and to protect fingers from excessive drying.

However, mere addition of a water-soluble humectant provides good rub resistance but poor water resistance. Further, the water resistance is good only by adding the oil-soluble emollient, but the friction resistance is not good. As a countermeasure against this, if a large amount of an emollient is mixed in order to improve the friction resistance, the fingers become sticky, which hinders the work. As described above, when both the water-soluble humectant and the emollient are added alone, the effect of suppressing hand roughness is insufficient, and no ethanol preparation having a sufficient effect of suppressing hand roughness has been found.

Against this background, JP-A-7-165571 discloses a composition containing a lower alcohol, a cationic disinfectant and a wetting agent in order to obtain a disinfecting composition free of rough hands and stickiness. In addition, it has been proposed to mix a predetermined polar oil and a cyclic or chain silicone, however, even with this composition, it cannot be said that the anti-hand roughness in frequent rubbing use is sufficiently suppressed.

[0010]

Means for Solving the Problems In order to solve the above-mentioned problems, the present inventors have made intensive studies and found that a disinfectant disinfectant composition using an amphiphilic amide derivative in combination with a lower alcohol and a cationic disinfectant has been used. The present inventors have found that even when the frequency is high, they do not cause rough hands, and have completed the present invention.

That is, the present invention provides a germicidal / disinfectant composition containing the following components (A), (B), (C) and (D). (A) Lower alcohol 30-95% by weight (B) Cationic fungicide 0.01-3.0% by weight (C) Amphiphilic amide derivative 0.01-5.0% by weight (D) Water

[0012]

Embodiments of the present invention will be described below in detail.

The germicidal disinfectant composition of the present invention can be used not only for in-hospital use for medical staff such as doctors and nurses, hospitalized or outpatients, but also for general use at home such as the elderly and home medical treatment sites. Disinfectant, and a disinfectant composition for hand disinfection that can be used everywhere, such as workers in the food processing industry including restaurants and restaurants.

The component (A) of the present invention is a lower alcohol, preferably ethanol and / or isopropanol, particularly preferably ethanol. Component (A) is the main component of the germicidal disinfectant composition of the present invention, and is contained in the composition in an amount of 30 to 95% by weight, preferably 70 to 80% by weight. Also, (A)
It is particularly preferred that ethanol accounts for 50 to 100% by weight of the components.

[0015] The composition of the present invention is added to the disinfectant composition.
Examples of the cationic germicide of the component (B), benzalkonium chloride C ₈ -C _18, benzethonium chloride, chlorhexidine gluconate, alkyl bromide isoquinolinium, C ₈ ~
Alkyl trimethyl ammonium chloride C _24, N-like cocoyl -L- arginine ethyl ester · DL-pyrrolidone carboxylate and the like, one or Of these 2
More than seeds are used. In particular benzalkonium chloride C ₈ -C ₁₈ are preferred in the present invention. In the present invention, the component (B) is contained in the composition in an amount of 0.01 to 3.0% by weight, preferably 0.05 to 0.3% by weight.
% By weight.

The fungicidal disinfectant composition of the present invention contains (C) an amphiphilic amide derivative in an amount of 0.01 to 5.0% by weight, preferably 0.1 to 5.0% by weight.
1.01.0% by weight. By blending the amide derivative in this range, a germicidal disinfectant composition that does not cause roughening even when frequently used can be obtained.

Here, (C) the amphipathic amide derivative is ceramide or a synthetic structural analogue thereof, and has two or more hydrophobic or hydrophilic groups such as a long-chain alkyl or alkenyl group in one molecule. A substance that has a hydroxyl group and an amide bond as a linking group, does not dissolve in water, and can be oriented.
As ceramide structural analogs, Japanese Patent Publication No. 62-4254,
JP-A-4-282304, JP-A-4-342553, JP-A-63-22751
No. 4, JP-A-2-306949, JP-A-6-145123, JP-A-6-145123
157507, JP-A-8-319263, JP-A-6-157283, WO94 / 07844 and the like. Commercially available sphingolipids E60, E66
(Manufactured by Kao Corporation), Questamide H (registered trademark, Quest
And the like).

As the amphiphilic amide derivative used in the present invention, a compound represented by the following general formula (1) is particularly preferred.

[0019]

Embedded image

(Wherein R ¹ and R ² are the same or different and each represent an optionally hydroxylated hydrocarbon group having 1 to 40 carbon atoms, and R ³ is a linear or branched chain having 1 to 6 carbon atoms) R ⁴ is a hydrogen atom, carbon number 1
It represents 12 linear or branched alkoxy groups or 2,3-dihydroxypropyloxy groups. However, when R ³ is a single bond, R ⁴ is a hydrogen atom. The amide derivative represented by the above general formula (1) is disclosed in
It can be produced by the method described in JP-A-319263.

The germicidal disinfectant composition of the present invention comprises the above (A)
The component (C) is essential, and the balance is water (D), but other components can also be blended.

The germicidal disinfectant composition of the present invention contains a wetting agent.
It is preferred to blend (E). As the wetting agent (E),
Polyhydric alcohols such as glycerin, diglycerin, ethylene glycol, propylene glycol, butylene glycol, erythritol, and sorbitol can be used. Among them, glycerin is preferable. These wetting agents
(E) is present in the composition at 0.01 to 10% by weight, preferably 0.3 to 10% by weight.
3.0% by weight.

It is preferable to add a feel improving agent (F) to the germicidal disinfectant composition of the present invention. Examples of the feel improving agent (F) include polyethylene glycol, TPS (polysaccharide derived from tuberose) and the like. These feel improvers
(F) is contained in the composition in an amount of 0.001 to 1.0% by weight, preferably 0.1 to 1.0% by weight.
005 to 0.5% by weight. In addition to the above, lactic acid or its alkali metal salts such as sodium and potassium, alkaline earth metal salts such as calcium, ammonium salts or alkanolamine salts, urea, NMF-related components such as sodium pyrrolidonecarboxylate, hyaluronic acid, chondroitin Acidic mucopolysaccharides such as sulfuric acid or salts thereof can be used. Among them, lactic acid or salts thereof are preferable, and sodium lactate is particularly preferable. These components are incorporated in the composition in an amount of 0.001 to 1.0% by weight, preferably 0.005 to 0.5% by weight.

[0024]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Preferred embodiments of the present invention will be described below. Note that the present invention is not limited to these examples. The percentages in the examples are on a weight basis unless otherwise specified.

Example 1 <Evaluation method of skin roughness scaling> A confirmation test of skin roughness scaling was performed by the following method. Ethanol preparations (products 1 to 38 of the present invention, comparative products 1 to 14) were applied to predetermined portions (5 cm ² , 10 sections) of the left and right arms on the forearm flexion side of 27 male subjects (23 to 46 years old). / Person: 2 untreated areas /
1 ml was applied to each formulation (including humans, the number of repetitions was set to 4), and this operation was performed 10 times a day for 5 consecutive days.

After 10 days from the end of application, the application area was observed with a microscope (Keyence, VH-6200, × 10 magnification)
The state of scaling was determined. The criteria were as follows. Judgment criteria: Evaluation of scaling 3: Peeling of the epidermis and stratum corneum is recognized quite frequently. 2: Many peeling of the epidermis and stratum corneum is observed. 1: Peeling of epidermis and stratum corneum is slightly recognized. 0: There is no change in the state of the epidermis and the stratum corneum as compared with the untreated part.

Tables 1 to 7 show the evaluation results of each ethanol preparation (blend). The displayed values are the average values of 26 persons.
The amphiphilic amide derivatives 1 to 3 used are as follows.

[0028]

Embedded image

[0029]

[Table 1]

[0030]

[Table 2]

[0031]

[Table 3]

[0032]

[Table 4]

[0033]

[Table 5]

[0034]

[Table 6]

[0035]

[Table 7]

Example 2 Using the product 23 of the present invention and the comparative product 16 prepared in Example 1, a test was conducted to confirm the effect of preventing hand roughness when used continuously.
Twenty male subjects (23-38 years old) were divided into two 10 subjects, and 3 ml of each ethanol preparation was evenly rubbed into the fingers.
They were used 10 times a day every 60 minutes for 14 consecutive days. The criteria were determined by self-evaluation according to the following. Table 8 shows the results.

[0037]

[Table 8]

Example 3 <Evaluation of the degree of recovery of the water content of the stratum corneum> The product 34 of the present invention prepared in Example 1 and the comparative product 12 were used to obtain the results shown in FIG.
The water content of the stratum corneum was evaluated according to the procedure shown in (1). 5 men (23
The forearm flexion site of a subject aged 36 to 36 years is forcibly made rough in advance with an 80% v / v aqueous ethanol solution, and the ethanol preparation composition is applied to predetermined portions (12 cm ² ) of the left and right arms respectively.
ml was applied. 60 minutes after application, the test site is washed (with physical load), the applied material on the epidermis is removed, and the horny layer moisture (skin conductance) is measured 60 minutes after washing, and the recovery rate of the skin conductance is measured. did. Table 9 shows the results. The skin conductance recovery rate 60 minutes after washing with water was determined by the following equation.

[0039]

(Equation 1)

[0040]

[Table 9]

[Brief description of the drawings]

FIG. 1 is a chart showing a procedure for measuring a skin conductance recovery rate in Example 3.

Claims (5)

[Claims] (1) The following components (A), (B), (C) and
A germicidal disinfectant composition comprising (D) a component. (A) Lower alcohol 30-95% by weight (B) Cationic fungicide 0.01-3.0% by weight (C) Amphiphilic amide derivative 0.01-5.0% by weight (D) Water 2. The disinfectant composition according to claim 1, wherein the lower alcohol as the component (A) is ethanol and / or isopropanol. 3. The amphiphilic amide derivative of the component (C) is an amide derivative represented by the following general formula (1).
Or the germicidal disinfectant composition according to 2. Embedded image (Wherein, R ¹ and R ² are the same or different and each represent an optionally hydroxylated hydrocarbon group having 1 to 40 carbon atoms, and R ³ is a linear or branched alkylene group having 1 to 6 carbon atoms. R ⁴ represents a hydrogen atom, a linear or branched alkoxy group having 1 to 12 carbon atoms or a 2,3-dihydroxypropyloxy group, provided that when R ³ is a single bond, R ⁴ represents a single bond; Is a hydrogen atom.) 4. The disinfectant composition according to claim 1, further comprising (E) 0.01 to 10% by weight of a wetting agent. 5. The disinfectant composition according to claim 1, further comprising (F) a feel improver in an amount of 0.001 to 1.0% by weight.