JPH09135887A - Solution for contact lens - Google Patents

Abstract

PROBLEM TO BE SOLVED: To enhance the sterilizing effect and to reduce the effective volume of a bactericide by adding ascorbicacid-phosphate estermagnecium salt and a sterilizing agent. SOLUTION: A solution for a contact lens contains ascorbic acid-phosphate estermagnecium salt (formula I) and bactericide. The concentration of the ascorbic acid-phosphate estermagnecium salt (formula I) is preferably greater than 0.1mM and less than 100mM. Cationic bactericide having a high sterilizing effect and being stable is used as the bactericide. When the solution is to be prepared, the components are dissolved in a sterilized purified water or physiological salt water. Accordingly, a sterilizing effect inherent to the bactericide is further enhanced so as to reduce the effective quantity of the bactericide, thereby it is possible to enhance the safety for the human body.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a liquid agent for contact lenses. More specifically, the present invention relates to a contact lens liquid agent which has a bactericidal effect for keeping a contact lens clean and can be suitably used when cleaning, disinfecting and storing the contact lens.

[0002]

2. Description of the Related Art Conventionally, cleaning, disinfection of contact lenses,
A germicidal agent is blended in the contact lens solution used for storage.

However, since the bactericide contained in the contact lens liquid preparation may cause eye disorders such as eye irritation, allergy and cell damage, the amount of the bactericide contained in the contact lens liquid preparation is sufficient. It is desired that the amount be as small as possible while exhibiting various bactericidal effects.

[0004]

DISCLOSURE OF THE INVENTION The present invention has been made in view of the above-mentioned prior art, in which the bactericidal effect originally possessed by the bactericide is further enhanced, and the effective amount of the bactericide is reduced. An object of the present invention is to provide a contact lens liquid agent capable of achieving the following.

[0005]

DISCLOSURE OF THE INVENTION The present invention relates to a liquid agent for contact lenses, which comprises ascorbic acid phosphate magnesium salt and a bactericide.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION As described above, the liquid agent for contact lens of the present invention contains ascorbic acid phosphoric acid ester magnesium salt and a bactericide.

One of the major features of the present invention is that the liquid agent for contact lenses contains magnesium ascorbyl phosphate magnesium salt.

The ascorbic acid phosphoric acid ester magnesium salt exhibits the excellent property of increasing the bactericidal effect of the bactericide. Therefore, it can be said that the ascorbic acid phosphoric acid ester magnesium salt is a component that further improves the bactericidal effect of the bactericidal agent.

Therefore, when the germicide is used in combination with ascorbic acid phosphate, the effective amount of the germicide can be reduced while exhibiting a sufficient germicidal effect.

The ascorbic acid phosphate magnesium salt has the formula (I):

[0011]

Embedded image

It is a compound represented by the formula (1), which is described in the Japan Cosmetics Ingredients Collection, and has the safety of not exhibiting acute toxicity, skin irritation, teratogenicity, chronic toxicity, reversion resistance, etc. It is described in numerous documents.

The concentration of ascorbic acid phosphoric acid ester magnesium salt contained in the liquid medicine for contact lenses of the present invention varies depending on the kind of the bactericide used, and therefore cannot be determined unconditionally. Usually, in order to sufficiently enhance the bactericidal effect of the bactericide, the concentration of the ascorbic acid phosphoric acid ester magnesium salt is preferably 0.01 mM or more, more preferably 0.1 mM or more, but if it is too much, On the contrary, since the bactericidal effect is reduced, the concentration of the magnesium salt of ascorbic acid phosphate is 100 mM or less, especially 50
It is preferably at most mM.

As the bactericide used in the present invention, a cationic bactericide is preferable because it has a large bactericidal effect and excellent stability.

Typical examples of the cationic bactericide include:
Examples thereof include benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, cetylpyridinium bromide, guazatine, albazone, chlorhexidine, and polyhexamethylene biguanidine. These cationic bactericides are usually used alone or in admixture of two or more. Among these cationic bactericides, benzalkonium chloride, benzethonium chloride and the like having an alkyl group preferably have 8 to 18 carbon atoms in the alkyl group in order to enhance antibacterial activity.

One of the indexes for evaluating the antibacterial activity of bactericides is
Minimum bactericidal concentration (Minimum Bactericide
l Concentration), which represents the minimum concentration of bactericide required to kill microorganisms (fungi).

The minimum bactericidal concentration of the bactericide differs depending on the type of the bactericide and the use conditions. For example, when chlorhexidine is used as a bactericide, the literature indicates that the minimum bactericidal concentration is Pseudomonas a ( Pseudomonas a).
eruginosa (ATCC 9027);
P. a. About 400 ppm for Escherichia coli (ATCC
8739); hereinafter, E. c. About 10)
When benzethonium chloride is used as a bactericide, the minimum bactericidal concentration is P.O. a. About 80
0 ppm, E. c. Is about 50 ppm, and when benzalkonium chloride is used as a bactericide, the minimum bactericidal concentration is P. a. About 200 ppm, E.
c. Is about 80 ppm.

The contact lens liquid agent of the present invention exhibits a minimum bactericidal concentration at a concentration of the bactericidal agent lower than the normally used minimum bactericidal concentration by the combined use of the bactericidal agent and ascorbic acid phosphate magnesium salt. is there.

The effective amount of the bactericide varies depending on the microorganism (bacteria) and the type and use conditions of the bactericide, but the minimum amount of sterilization necessary for the contact lens solution of the present invention to kill the microorganism (bacteria). The concentration of the agent. Usually, the effective amount of the bactericide is 5 to 80 which is the minimum bactericidal concentration of the bactericide.
A sufficient bactericidal effect is exhibited even when the content is wt%, preferably 7 to 65 wt%.

The contact lens solution of the present invention may contain, if necessary, a buffer such as a phosphate buffer, a borate buffer, a citrate buffer, or an isotonic sodium chloride or potassium chloride solution. Agent, water-soluble surfactant,
A chelating agent such as ethylenediaminetetraacetic acid can be added in an amount within the range that does not impair the object of the present invention.

In order to make it isotonic, the osmotic pressure is 200 to 400 mmo using, for example, sodium chloride.
It may be 1 / kg, especially 270-320 mmol / kg.

In preparing the contact lens liquid preparation of the present invention, no special method is particularly required, and each component is added to predetermined sterile purified water, physiological saline, etc. in the same manner as in the case of preparing an ordinary aqueous solution. By dissolving
The liquid agent for contact lenses of the present invention can be obtained.

The obtained contact lens solution is clear, and if necessary, such contact lens solution can be subjected to aseptic filtration or the like.

By dipping a contact lens in the contact lens solution, the contact lens can be preserved and sterilized, and the contact lens solution can be used for rinsing and rubbing with fingers. As a result, the contact lens can be rinsed, washed, and disinfected.

As described above, the contact lens liquid composition of the present invention is further combined with an ascorbic acid phosphoric acid ester magnesium salt in addition to the bactericidal agent, so that the bactericidal effect of the bactericidal agent is further enhanced. It is possible to reduce the effective amount of the bactericide.

[0026]

EXAMPLES Next, the liquid agent for contact lenses of the present invention will be described in more detail based on examples, but the present invention is not limited to these examples.

Examples 1 and 2 and Comparative Example 1 Ascorbic acid phosphate magnesium salt was added at a concentration of 0 mM (Comparative Example 1), 1 mM (Example 1) or 1
The solution was dissolved in physiological saline to a concentration of 0 mM (Example 2), and chlorhexidine as a bactericide was added to the solution to a concentration of 50 ppm and dissolved.

Next, the obtained solution was added to a pore size of 0.2.
A sterile test solution (solution for contact lenses) was obtained by filtering with a 0 μm sterile membrane filter.

Using the sterilized test solution thus obtained, its sterilizing effect was examined according to the following sterilizing effect test method. Table 1 shows the results.

(Test method for bactericidal effect) As a test bacterium , Candida albicans was used.
s (ATCC 10231), hereinafter C.I. a. ,), E. c. Or P. a. Was used.

The test bacteria were suspended in physiological saline and the number of bacteria was 1
A bacterial suspension of 0 ⁷ to 10 ⁸ cfu / ml was prepared.

Next, 10 ml of the test solution was injected into the test tube, then 50 μl of the bacterial suspension was injected, and the test solution was stored in a thermostat at 25 ° C.

After a lapse of 60 minutes or 240 minutes from the start of storage, an appropriate amount of the test solution was collected, diluted with sterilized physiological saline, and the viable cell count was determined by the pour plate method (the number of colonies on the agar plate was counted. I asked for). At this time, C.I.
a. For 5 days at 25 ° C. c. And P.
a. Was cultured at 35 ° C. for 3 days.

The viable cell count at the start of the test was determined by the pour plate method after appropriately diluting the prepared bacterial suspension with sterile physiological saline.

Comparative Example 2 A contact lens solution was prepared in the same manner as in Example 1 except that chlorhexidine was not used, and the sterilizing effect was examined. Table 1 shows the results.

Comparative Example 3 A contact lens solution was prepared in the same manner as in Example 2 except that chlorhexidine was not used, and the bactericidal effect was examined. Table 1 shows the results.

[0037]

[Table 1]

From the results shown in Table 1, comparing Examples 1 and 2 with Comparative Example 1, when a bactericidal agent (chlorhexidine) and an ascorbic acid phosphate magnesium salt were used in combination ( It can be seen that the viable cell count is remarkably smaller and the bactericidal effect is superior to those of Examples 1 and 2) and the case of using only the bactericide (Comparative Example 1).

When Example 1 is compared with Comparative Example 2 and Example 2 is compared with Comparative Example 3, only ascorbic acid phosphoric acid ester magnesium salt is used without using the bactericide (chlorhexidine). (Comparative Examples 2 to 3), it can be seen that the bactericidal effect is hardly exhibited.

From the above, it is understood that when the bactericide and the magnesium phosphate ascorbate salt are used together, the bactericidal effect originally possessed by the bactericide is further enhanced.

[0041]

The contact lens liquid agent of the present invention comprises:
Ascorbic acid phosphoric acid ester magnesium salt that is safe for the human body is used, and since the ascorbic acid phosphoric acid ester magnesium salt further enhances the bactericidal effect that the bactericidal agent originally has, the effectiveness of the bactericidal agent is improved. The effect is that the amount can be reduced and the safety for the human body can be enhanced.

Claims (3)

[Claims] 1. A contact lens solution comprising an ascorbic acid phosphate magnesium salt and a bactericide. 2. The liquid agent for contact lenses according to claim 1, wherein the concentration of the magnesium salt of ascorbic acid phosphoric acid ester is 0.01 to 100 mM. 3. The contact lens liquid preparation according to claim 1, wherein the bactericide is a cationic bactericide.