JPH078275B2 - In vivo equivalent current dipole tracker - Google Patents
In vivo equivalent current dipole trackerInfo
- Publication number
- JPH078275B2 JPH078275B2 JP63182163A JP18216388A JPH078275B2 JP H078275 B2 JPH078275 B2 JP H078275B2 JP 63182163 A JP63182163 A JP 63182163A JP 18216388 A JP18216388 A JP 18216388A JP H078275 B2 JPH078275 B2 JP H078275B2
- Authority
- JP
- Japan
- Prior art keywords
- current dipole
- calculating
- potential
- equivalent current
- measuring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000001727 in vivo Methods 0.000 title claims description 8
- 238000005259 measurement Methods 0.000 claims description 24
- 210000003128 head Anatomy 0.000 claims description 16
- 210000004761 scalp Anatomy 0.000 claims description 15
- 238000006073 displacement reaction Methods 0.000 claims description 10
- 238000004364 calculation method Methods 0.000 description 9
- 210000003625 skull Anatomy 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 7
- 238000013480 data collection Methods 0.000 description 7
- 238000004070 electrodeposition Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 210000004556 brain Anatomy 0.000 description 3
- 210000004958 brain cell Anatomy 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000008035 nerve activity Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 208000014644 Brain disease Diseases 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000007177 brain activity Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Landscapes
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は、脳疾患の臨床診断や脳神経系の機能の解明に
用いる生体内等価電流双極子追跡装置に係り、特に生体
の神経活動を電流双極子に置換し、この置換によって体
表上に投影される電位分布から逆に電流双極子の発生源
に関する情報を得るようにした等価電流双極子追跡装置
に関する。Description: TECHNICAL FIELD The present invention relates to an in vivo equivalent current dipole tracking device used for clinical diagnosis of brain diseases and elucidation of functions of the cranial nervous system. The present invention relates to an equivalent current dipole tracking device which substitutes a dipole and obtains information on the source of the current dipole from the potential distribution projected on the body surface by this substitution.
従来から、生体の神経活動により、体表面上に現われる
電位を測定する装置としては脳波計、筋電計、誘発電位
加算装置等が使用されている。近時、生体の神経活動に
伴って体表面上に発生する電位を計測し、生体内の活動
部位を推定する等価双極子法が提案されている。この方
法は例えば、脳の各活動部位の細胞が刺激されると起電
力を発生して、脳波上に電位分布を生ずる。この様な電
位分布から各部位を電気的な双極子で対応させ、この双
極子の位置とベクトル成分を上述の電位分布から演算し
て活動している脳細胞の位置を推定することにより脳の
活動状態を追跡する様にしたものである。この様な双極
子を推定する等価双極子法に於ては、双極子が発生する
電位分布を繰り返し演算する関係から、あまり複雑な頭
蓋モデルを使うことは計算量の点から現実的でなく、最
初は被験者の頭を球又は同心球で置き換えるというもの
が大部分であった。しかし、球状でない頭蓋を球状モデ
ルで近似する方法は電位計算に誤差を伴うばかりでなく
推定された等価双極子の位置が脳内のどこに対応してい
るかが判然としなかった。Conventionally, an electroencephalograph, an electromyogram, an evoked potential adding device, etc. have been used as a device for measuring the potential appearing on the body surface by the nerve activity of the living body. Recently, an equivalent dipole method has been proposed in which the potential generated on the body surface is measured with the nerve activity of the living body and the active site in the living body is estimated. This method, for example, generates an electromotive force when a cell at each active site of the brain is stimulated to generate a potential distribution on the electroencephalogram. Corresponding each part with an electric dipole from such a potential distribution, the position of this dipole and the vector component are calculated from the above potential distribution, and the position of the active brain cell is estimated by estimating the position of the brain cell. It is designed to track the activity status. In the equivalent dipole method for estimating such a dipole, it is not realistic to use a very complicated cranial model from the viewpoint of the amount of calculation because of the relation that the electric potential distribution generated by the dipole is repeatedly calculated. Initially, most of the time, the subject's head was replaced with a sphere or a concentric sphere. However, the method of approximating a non-spherical skull with a spherical model not only involves errors in the potential calculation, but it was not clear where the estimated position of the equivalent dipole corresponds to in the brain.
最近、この頭蓋形状を考慮するアルゴリズムが開発さ
れ、またコンピュータの発達により高速計算が可能とな
り、ソフト面でもコンピュータのグラフィック技術が進
歩したこともあり、等価双極子をかなり正確に推定でき
る新技術が確立された（例えば特願昭62−285728号，特
願昭63−86463号の明細書及び図面を参照）。Recently, an algorithm that considers this skull shape has been developed, high-speed calculation has become possible due to the development of computers, and computer graphics technology has advanced in terms of software.Therefore, there is a new technology that can estimate the equivalent dipole fairly accurately. It has been established (see, for example, the specification and drawings of Japanese Patent Application No. 62-285728 and Japanese Patent Application No. 63-86463).
この場合、電位分布を測定するための電極は、被験者の
頭部（頭蓋）寸法を測りながら１電極ずつ装着し、電極
位置の情報はキーボード等の入力装置から電位計算を行
わせるコンピュータに入力している。また、頭部（頭
蓋）形状を知る手段としては、Ｘ線CT（コンピュータ・
トモグラフ）やMRI（核磁気共鳴コンピュータ・トモグ
ラフ）などから得られる画像情報を元にしている。In this case, the electrodes for measuring the potential distribution are attached one electrode at a time while measuring the size of the subject's head (skull), and the information on the electrode positions is input from an input device such as a keyboard to a computer for calculating the potential. ing. In addition, as a means to know the shape of the head (skull), X-ray CT (computer
It is based on image information obtained from tomographs and MRI (nuclear magnetic resonance computer tomographs).
電極の装置を人間の手により行った場合、頭皮上の電極
の位置とコンピュータに入力される電極位置情報とを正
確に一致させることは困難であり、その結果、起電力源
の位置を正確に算出するときに誤差を生じてしまう。When the electrode device is operated by human hands, it is difficult to accurately match the position of the electrode on the scalp and the electrode position information input to the computer, and as a result, the position of the electromotive force source can be accurately determined. An error will occur when calculating.
また、Ｘ線CTやMRIは脳内の構造的異常についての情報
を得るものであり、単に頭蓋形状を測定する為だけに使
用することを考えると、測定時間を要し、コスト的にも
メリットがない。In addition, X-ray CT and MRI are used to obtain information about structural abnormalities in the brain, and considering that they are used only to measure the shape of the skull, they require measurement time and are cost-effective. There is no.
本発明では、上記の問題点を解消し、被験者に肉体的に
も精神的にも苦痛を与えないで、しかも短時間に電極を
自動装着し、同時に頭部（頭蓋）形状の情報と正確なる
電極位置情報及び頭皮上の電位分布が得られるデータ収
集部を備えた生体内等価電流双極子追跡装置を提供する
ことを目的としたものである。According to the present invention, the above problems are solved, the electrodes are automatically attached in a short time without causing physical or mental pain to the subject, and at the same time, the head (cranium) shape information becomes accurate. It is an object of the present invention to provide an in-vivo equivalent current dipole tracking device provided with a data collection unit capable of obtaining electrode position information and potential distribution on the scalp.
本発明の装置のデータ収集部の原理的な構成と機能を第
２図に示す。以下第２図に従って説明する。FIG. 2 shows the basic configuration and function of the data collection unit of the device of the present invention. This will be described below with reference to FIG.
測定基準面21は平均的な人の頭蓋より例えば20〜30mm大
きな形状をしたヘルメットのようなもので、被験者はこ
のヘルメットをかぶらせ、この面を測定の基準面とす
る。距離測定兼電位測定手段22は、被験者にヘルメット
をかぶらせたときに、被験者の頭皮と測定基準面21との
距離を、測定基準面の格子上の例えば100点について測
定し、同時にその点における頭皮上の電位を測定できる
手段である。距離測定兼電位測定手段22の出力Ａは距離
を示す情報であり、距離−電圧変換手段23にて電圧値に
変換される。距離−電圧変換手段23の出力Ｂはアナログ
値なので、A/D変換手段（＃１）24によりディジタル値
に変換され、出力Ｃは計算手段25に入力される。計算手
段25にはあらかじめ測定基準面21の形状を示す情報を測
定点の正確なる測定基準面上の位置に情報が入力されて
おり、これら情報とA/D変換手段24の出力Ｃすなわち各
測定点における測定基準面と頭皮上との距離情報から計
算手段25にて計算し頭部（頭蓋）形状を求めるわけであ
る。得られる頭部形状データは記憶手段26に記憶され
る。The measurement reference plane 21 is like a helmet having a shape larger than the skull of an average person by, for example, 20 to 30 mm. The subject puts on this helmet and uses this surface as a reference plane for measurement. Distance measuring and potential measuring means 22, when the subject is wearing a helmet, the distance between the subject's scalp and the measurement reference plane 21, for example, at 100 points on the grid of the measurement reference plane, at the same time at that point. It is a means of measuring the potential on the scalp. The output A of the distance measuring / potential measuring means 22 is information indicating the distance and is converted into a voltage value by the distance-voltage converting means 23. Since the output B of the distance-voltage conversion means 23 is an analog value, it is converted into a digital value by the A / D conversion means (# 1) 24, and the output C is input to the calculation means 25. Information indicating the shape of the measurement reference plane 21 is input to the calculation means 25 in advance at a position on the measurement reference plane at which the measurement point is accurate. The information and the output C of the A / D conversion means 24, that is, each measurement From the distance information between the measurement reference plane at the point and the scalp, the calculation means 25 calculates the head (skull) shape. The obtained head shape data is stored in the storage means 26.
一方、距離測定兼電位測定手段22の出力Ｄは距離測定点
における頭皮上の電位を示すものであり電位増幅手段27
により増幅され、出力ＥとしてA/D変換手段（＃２）28
に入力される。A/D変換手段（＃２）28の出力Ｆは計算
手段25に入力されている。この情報を正確なる位置情報
（先に示した頭部形状に算出する時に得られる。）を伴
った頭皮上の電位情報として計算手段25に取り込むわけ
である。得られた電位測定データは記憶手段26に記憶さ
れる。On the other hand, the output D of the distance measuring and potential measuring means 22 indicates the potential on the scalp at the distance measuring point, and the potential amplifying means 27
A / D conversion means (# 2) 28 which is amplified by
Entered in. The output F of the A / D conversion means (# 2) 28 is input to the calculation means 25. This information is taken into the calculation means 25 as potential information on the scalp accompanied by accurate position information (obtained when calculating the head shape shown above). The obtained potential measurement data is stored in the storage means 26.
この様に構成されたデータ収集部で得られた頭部形状デ
ータと正確な位置（電極の位置）情報を伴った頭皮電位
測定データは外部記憶装置（例えばフロッピーディス
ク）を介して、生体内等価電流双極子追跡装置の本体部
（追跡・表示部）へ送られる。The head shape data obtained by the data collection unit configured in this way and the scalp potential measurement data with accurate position (electrode position) information are equivalent to the in-vivo data via an external storage device (eg, floppy disk). It is sent to the main body (tracking / display) of the current dipole tracking device.
本体部は、生体内の任意の位置に電流双極子を仮定し、
電流双極子によって作られる複数の電極に夫々対応する
電位を演算する演算手段と、前記電位測定手段の実測値
と上記演算手段の計算値との間の二乗誤差を演算する二
乗誤差演算手段と、二乗誤差演算手段から得た二乗誤差
値を最小にする電流双極子の位置とベクトル成分を求め
て等価電流双極子とする等価電流双極子設定手段と、上
記電位測定手段の実測値と上記等価電流双極子設定手段
から残差を求めて所定値以上の近似度を演算する近似度
演算手段とを有して構成されている。なお、この本体部
の構成と機能についての詳細は、例えば前記の特願昭63
−86463号の明細書と図面を参照されたい。The body part assumes a current dipole at any position in the living body,
A calculating means for calculating a potential corresponding to each of the plurality of electrodes formed by the current dipole; and a square error calculating means for calculating a squared error between the measured value of the potential measuring means and the calculated value of the calculating means, Equivalent current dipole setting means for obtaining the position and vector component of the current dipole that minimizes the squared error value obtained from the squared error calculating means, the measured value of the potential measuring means and the equivalent current And a degree-of-approximation calculating means for calculating a residual from the dipole setting means and calculating the degree of approximation of a predetermined value or more. The details of the structure and function of the main body are described in, for example, the above-mentioned Japanese Patent Application No.
-86463, see the specification and drawings.
脳内活動による起電力源の位置を頭皮電位分布から測定
する場合において、十分に正確な頭蓋形状の測定がMRI
などの大規模装置を使用せずに被験者にヘルメットをか
ぶせるだけでおこなえ、同時に電極を自動装着し、正確
なる電極位置情報及び頭皮上の電位分布を得ることがで
き、しかも短時間（例えば測定時間20ms）でおこなえ
る。When measuring the position of the electromotive force source due to brain activity from the scalp potential distribution, a sufficiently accurate cranial shape measurement is MRI.
It can be done by putting a helmet on the subject without using a large-scale device such as etc., and at the same time, the electrode can be automatically attached, accurate electrode position information and potential distribution on the scalp can be obtained, and in a short time (for example, measurement time 20ms).
本発明の一実施例について第１図に示したブロック図を
用いて説明する。An embodiment of the present invention will be described with reference to the block diagram shown in FIG.
測定基準面１（ヘルメット）には、格子上（第３図参照
のこと）に＃１〜＃100までの100個の変位センサ２が取
付けられている。変位センサ２（＃１〜＃100）と基準
電圧電源３の構成により第２図の距離測定兼電位測定手
段22と距離−電圧変換手段23とを実現している。On the measurement reference plane 1 (helmet), 100 displacement sensors 2 # 1 to # 100 are attached on a grid (see FIG. 3). The configuration of the displacement sensor 2 (# 1 to # 100) and the reference voltage power supply 3 realizes the distance measuring / potential measuring means 22 and the distance-voltage converting means 23 of FIG.
変位センサ単体は第４図（ａ）に示すように、通常、測
定棒41はバネ42により一番引き出された状態になってい
る（例えばａは50mm）。ヘルメットを被験者の頭にかぶ
せ、何らかの方法でヘルメットと頭蓋を固定すると、第
４図（ｃ）に示すように測定棒41は頭皮により押し上げ
られた状態となる。センサ本体43には端子があり第４図
（ｂ）の電気的等価回路が示すとうり、測定棒の長さａ
に比例し、端子〜間の抵抗値が変化するので、端子
に基準電圧電源から一定電圧を供給すれば、端子〜
間の電圧V23はａに比例した電圧値が得られる。変位
センサ２の＃１〜＃100のうち、例えば32個は第４図
（ｄ）に示すように、センサ本体43にさらに端子があ
り、測定棒41に電線等で結線されている。ここで測定棒
41は導体であり、被験者にヘルメットをかぶせたとき、
測定棒41の先端が頭皮に接触するので、同時に電位測定
電極となる。なお、測定棒を絶縁体で作り、内部に導体
を通して埋め込み型の測定電極を設けるようにしてもよ
い。As shown in FIG. 4 (a), the displacement sensor alone normally has the measuring rod 41 in the most pulled-out state by the spring 42 (for example, a is 50 mm). When the helmet is put on the subject's head and the helmet and the skull are fixed by some method, the measuring rod 41 is pushed up by the scalp as shown in FIG. 4 (c). The sensor body 43 has terminals, and the electrical equivalent circuit of FIG.
The resistance value between the terminals changes in proportion to, so if a constant voltage is supplied to the terminals from the reference voltage power supply,
A voltage value proportional to a can be obtained as the voltage V 23 between them. Of the displacement sensors 2 # 1 to # 100, for example, 32 of them, as shown in FIG. 4 (d), further have terminals on the sensor body 43 and are connected to the measuring rod 41 by electric wires or the like. Measuring rod here
41 is a conductor, and when the subject wears a helmet,
Since the tip of the measuring rod 41 comes into contact with the scalp, it also serves as a potential measuring electrode. Alternatively, the measuring rod may be made of an insulating material, and an embedded measuring electrode may be provided through a conductor.
端子の出力は増幅器４にて増幅され、マルチプレクサ
５、A/D変換器６を介してパーソナルコンピュータ10の
入力ポート11に送られる。The output of the terminal is amplified by the amplifier 4 and sent to the input port 11 of the personal computer 10 via the multiplexer 5 and the A / D converter 6.
端子に得られたセンサ出力はマルチプレクサ７、A/D
変換器６を介してパーソナルコンピュータ10の入力ポー
ト11に送られる。なお、マルチプレクサ５と７の選択し
た信号をディジタル信号に変換するのに一つのA/D変換
器６で兼用させて行っているので、切換器８を設けてい
るが、A/D変換器を二つ設けて独立に信号の変換処理を
行うように構成し、変換器を省くようにしてもよい。The sensor output obtained at the terminal is the multiplexer 7, A / D
It is sent to the input port 11 of the personal computer 10 via the converter 6. Since one A / D converter 6 also serves to convert the signals selected by the multiplexers 5 and 7 into a digital signal, the switching device 8 is provided, but the A / D converter is Two converters may be provided to perform the signal conversion processing independently, and the converter may be omitted.
パーソナルコンピュータ10は、制御手段及び演算手段用
のCPU13,ROM14,RAM15,キーボード16と、入力ポート11,
出力ポート12を備え、さらに外部記憶装置17として例え
ばフロッピーディスクが接続されている。The personal computer 10 includes a CPU 13, a ROM 14, a RAM 15, a keyboard 16 for the control means and the arithmetic means, an input port 11,
An output port 12 is provided, and a floppy disk, for example, is connected as the external storage device 17.
ここまで述べてきた各構成要素により、生体内等価電流
双極子追跡装置のデータ収集部が構成されている。な
お、説明が後になってしまったが、マルチプレクサ５
は、パーソナルコンピュータ10の出力ポート12より出力
される選択信号S1により、32個の電位測定電極のうちの
どの増幅器出力をA/D変換器６のアナログ入力に接続す
るかを決定する役割をはたす。The data collection unit of the in-vivo equivalent current dipole tracking device is configured by the components described above. Note that the multiplexer 5
Has a role of determining which amplifier output of the 32 potential measuring electrodes is connected to the analog input of the A / D converter 6 by the selection signal S 1 output from the output port 12 of the personal computer 10. Support
マルチプレクサ７は、同じく選択信号S2により、＃１〜
＃100までの100個の変位センサ２のうち、どのセンサ出
力をA/D変換器６のアナログ入力に接続するかを決定す
る役割をはたす。Multiplexer 7 is also by the selection signal S 2, #. 1 to
It plays a role of determining which sensor output of 100 displacement sensors 2 up to # 100 is connected to the analog input of the A / D converter 6.
パーソナルコンピュータ10は、キーボード16より、ある
コードが入力されると、出力ポート12より選択信号S1,S
2とA/D変換スタート信号S3を出力し、第５図に示したフ
ローチャートに従って電位測定を行ない、第６図に示し
たフローチャートに従って頭部形状計測を行う。When a certain code is input from the keyboard 16, the personal computer 10 outputs selection signals S 1 and S from the output port 12.
2 and the A / D conversion start signal S 3 are output, the potential is measured according to the flowchart shown in FIG. 5, and the head shape is measured according to the flowchart shown in FIG.
次に装置の本体部（追跡・表示部）の説明をする。本体
部30は制御手段及び演算手段用にCPU31,ROM32,RAM33,と
データ収集部20で得られたデータを記憶された外部記憶
装置（例えばフロッピーディスク）17を接続する入出力
ポート34及び双極子等の表示用のプリンタ36や表示器
（CRT）37等を接続する出力ポート35を有するコンピュ
ータで構成されている。Next, the main body (tracking / display) of the apparatus will be described. The main body unit 30 is a CPU 31, ROM 32, RAM 33 for control means and arithmetic means, and an input / output port 34 and a dipole for connecting an external storage device (for example, a floppy disk) 17 in which data obtained by the data collecting unit 20 is stored. It is composed of a computer having an output port 35 for connecting a printer 36 for displaying etc. and a display (CRT) 37 etc.
この本体部の動作は第７図のフローチャートで示した通
りである。先ず電源を“オン”して生体内等価電流双極
子追跡装置を第１ステップST1に示す様に初期状態に設
定する。次の第２ステップST2では各種演算用のプログ
ラム及び信号処理用のプログラム等を外部記憶装置17か
ら読み出してコンピュータ内のRAM33に格納する。この
様なプログラムはコンピュータ内の不揮発性メモリであ
るROM32内に予め記憶して置けば第２ステップST2は不要
となる。The operation of this main body is as shown in the flowchart of FIG. First, the power is turned on to set the in-vivo equivalent current dipole tracking device to the initial state as shown in the first step ST 1 . In the next second step ST 2 , various calculation programs and signal processing programs are read from the external storage device 17 and stored in the RAM 33 in the computer. If such a program is stored in advance in the ROM 32, which is a non-volatile memory in the computer, the second step ST 2 becomes unnecessary.
次の第３ステップST3,ではデータ収集部20より収集され
た頭部形状および頭皮電位測定データを外部記憶装置17
を介してRAM33に記憶する。以下のステップは従前（例
えば特願昭62−285728号）のものと同一である。In the next third step ST 3 , the head shape and scalp potential measurement data collected by the data collection unit 20 is stored in the external storage device 17
It is stored in the RAM 33 via. The following steps are the same as those in the prior art (for example, Japanese Patent Application No. 62-285728).
上記実施例の説明では、変位センサや電極の数等を説明
したが、これらの数はあくまでも一例であり、本発明は
これにより限定されるものではなく。種々の変更が可能
である。Although the number of displacement sensors and electrodes and the like have been described in the above description of the embodiments, these numbers are merely examples, and the present invention is not limited thereto. Various changes are possible.
以上説明したように、本発明によれば、非常に取扱いが
簡便でしかも短時間に頭部（頭蓋）形状測定及び正確な
頭皮上の電位分布の測定が可能となり、確立された新技
術を臨床診断等へ利用できる具体的なシステムを比較的
安価に構成することができる。As described above, according to the present invention, the handling of the head (cranium) shape and the accurate measurement of the potential distribution on the scalp can be performed very easily and in a short time. A specific system that can be used for diagnosis and the like can be constructed at a relatively low cost.
第１図は本発明の構成と動作を示すブロック図、第２図
は本発明のデータ収集部の原理的な構成と機能の説明
図、第３図は測定ポイントの説明図である。第４図は変
位センサと測定棒の説明図で、同図の（ａ）は構造、
（ｂ）は電気的等価回路、（ｃ）は動作、（ｄ）は測定
棒と電極の説明図である。第５図は電位測定のフローチ
ャート、第６図は頭部形状計測のフローチャート、第７
図は本発明の装置本体部の動作を示したフローチャート
である。 1,21……測定基準面（ヘルメット）、 ２……変位センサ、 ３……基準電圧電源、 ４……増幅器、 5,7……マルチプレクサ、 ６……A/D変換器、 10……パーソナルコンピュータ、 17……外部記憶装置、 20……データ収集部、 30……本体部、 41……測定棒。FIG. 1 is a block diagram showing the configuration and operation of the present invention, FIG. 2 is an explanatory diagram of the fundamental configuration and function of the data collection unit of the present invention, and FIG. 3 is an explanatory diagram of measurement points. FIG. 4 is an explanatory view of the displacement sensor and the measuring rod, in which (a) is a structure,
(B) is an electrical equivalent circuit, (c) is operation | movement, (d) is explanatory drawing of a measuring rod and an electrode. FIG. 5 is a potential measurement flowchart, FIG. 6 is a head shape measurement flowchart, and FIG.
The figure is a flow chart showing the operation of the apparatus main body of the present invention. 1,21 …… Measurement reference plane (helmet), 2 …… Displacement sensor, 3 …… Reference voltage power supply, 4 …… Amplifier, 5,7 …… Multiplexer, 6 …… A / D converter, 10 …… Personal Computer, 17 ... External storage device, 20 ... Data collection unit, 30 ... Main body unit, 41 ... Measuring rod.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 庁内整理番号 ＦＩ 技術表示箇所 // Ａ６１Ｂ 5/05 Ａ 7638−4Ｃ (72)発明者 足立 正博 東京都八王子市元本郷町１丁目９番９号 中央電子株式会社内 (56)参考文献 特開 昭60−227732（ＪＰ，Ａ) 特開 昭52−81981（ＪＰ，Ａ) 特開 平１−126949（ＪＰ，Ａ) 特開 平１−256931（ＪＰ，Ａ) 実開 昭49−134986（ＪＰ，Ｕ) 電気学会雑誌 第106巻５号 ＰＰ．409 〜412─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. 6 Identification number Reference number within the agency FI Technical indication location // A61B 5/05 A 7638-4C (72) Inventor Masahiro Adachi 1 Motohongocho, Hachioji, Tokyo 9-9 9 Chuo Denshi Co., Ltd. (56) Reference JP-A-60-227732 (JP, A) JP-A-52-81981 (JP, A) JP-A-1-126949 (JP, A) JP-A Hei 1-2596931 (JP, A) Actual development Sho 49-134986 (JP, U) The Institute of Electrical Engineers of Japan Vol. 106, No. 5, PP. 409 ~ 412
Claims (2)
を規定するヘルメットと、該ヘルメットの所定の測定ポ
イントに頭皮面に接触し伸縮自在な測定棒を突出させて
設けた変位センサを用いて構成した頭部形状計測手段
と、 生体に装着された複数の電極が検出した電位を測定する
電位測定手段と、 生体内の任意の位置に電流双極子を仮定し、該電流双極
子によって作られる上記複数の電極に夫々対応する電位
を演算する演算手段と、 上記電位測定手段の実測値と、上記演算手段の計算値と
の間の二乗誤差を演算する二乗誤差演算手段と、 上記二乗誤差演算手段から得た二乗誤差値を最小にする
電流双極子の位置とベクトル成分を求めて等価電流双極
子とする等価電流双極子設定手段と、上記電位測定手段
の実測値と上記等価電流双極子設定手段から残差を求め
て所定値以上の近似度を演算する近似度演算手段とを有
することを特徴とする生体内等価電流双極子追跡装置。1. A helmet mounted on the head to define a measurement point and a measurement reference plane, and a displacement sensor provided at a predetermined measurement point of the helmet by projecting a stretchable measuring rod in contact with the scalp surface. A head shape measuring means configured by using, a potential measuring means for measuring the potential detected by a plurality of electrodes attached to a living body, a current dipole is assumed at an arbitrary position in the living body, and the current dipole is used. Calculating means for calculating potentials respectively corresponding to the plurality of electrodes to be formed; square error calculating means for calculating a squared error between the measured value of the potential measuring means and the calculated value of the calculating means; Equivalent current dipole setting means for obtaining the position and vector component of the current dipole that minimizes the squared error value obtained from the error calculating means, and the equivalent current dipole setting means, the measured value of the potential measuring means and the equivalent current dipole. Child An in-vivo equivalent current dipole tracking device, comprising: an approximation degree calculating means for obtaining a residual from the determining means and calculating an approximation degree equal to or larger than a predetermined value.
極を設け、頭部形状計測手段と電位測定手段を一体化構
成した請求項１記載の生体内等価電流双極子追跡装置。2. The in-vivo equivalent current dipole tracking device according to claim 1, wherein a living body mounting electrode is provided at the tip of the measuring rod of the displacement sensor, and the head shape measuring means and the potential measuring means are integrally configured.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63182163A JPH078275B2 (en) | 1988-07-21 | 1988-07-21 | In vivo equivalent current dipole tracker |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63182163A JPH078275B2 (en) | 1988-07-21 | 1988-07-21 | In vivo equivalent current dipole tracker |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0231736A JPH0231736A (en) | 1990-02-01 |
| JPH078275B2 true JPH078275B2 (en) | 1995-02-01 |
Family
ID=16113454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63182163A Expired - Lifetime JPH078275B2 (en) | 1988-07-21 | 1988-07-21 | In vivo equivalent current dipole tracker |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH078275B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006325754A (en) * | 2005-05-24 | 2006-12-07 | Brain Research & Development:Kk | Electroencephalogram (eeg) dipole tracing apparatus, eeg dipole tracing method, program for eeg dipole tracing, and storage medium storing the program |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101980658A (en) * | 2008-03-27 | 2011-02-23 | 皇家飞利浦电子股份有限公司 | Method and system for measuring an object of interest |
| CN104352238A (en) * | 2014-11-08 | 2015-02-18 | 天津大学 | Method of collecting electrical resistance chromatographic chromatographic data of thoracic cavity of human body |
-
1988
- 1988-07-21 JP JP63182163A patent/JPH078275B2/en not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| 電気学会雑誌第１０６巻５号ＰＰ．４０９〜４１２ |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006325754A (en) * | 2005-05-24 | 2006-12-07 | Brain Research & Development:Kk | Electroencephalogram (eeg) dipole tracing apparatus, eeg dipole tracing method, program for eeg dipole tracing, and storage medium storing the program |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0231736A (en) | 1990-02-01 |
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