JPH0753234B2 - Emulsified composition - Google Patents

Description

TECHNICAL FIELD The present invention relates to an emulsified composition deeply related to various industrial fields such as foods, cosmetics, quasi drugs, pharmaceuticals, toiletries and the like.

[Conventional technology]

In recent years, a lot of researches on emulsification have been carried out, new emulsifiers or emulsification techniques have made remarkable progress, and very stable emulsions have been widely used in various industrial fields. However, most of them are nonionic surfactants, anionic surfactants, cationic surfactants,
Alternatively, a synthetic product such as an amphoteric surfactant is used as an emulsifier. Thus, for example, triethanolamine
It is well known that higher fatty acid-based emulsifiers have allergic properties depending on their constitution. Also, it is difficult to adjust the pH value with caustic potash / higher fatty acid-based emulsifiers, and it is difficult to use at high temperatures. There is a risk of developing allergenicity when the amount of borax used is large, such as deterioration of the emulsifying property below, and for borax and beeswax emulsifiers.
Since polyoxyethylene-based products have problems with skin irritation and the like, general consumers are particularly cautious about safety to the human body, and anxiety is recently increasing.
Further, recently, an emulsified composition utilizing a protein represented by sodium caseinate, a water-soluble natural polymer such as saponin, and lecithin has been developed. These are highly technically utilized natural surfactants as emulsifiers, but many consumers feel uneasy only because they are surfactants.

[Problems to be solved by the invention]

As described above, most of the emulsions that have been widely used in various industrial fields are those that use surfactants, and it can be said that there are no problems with safety and irritation, and general consumers There was a problem when he was given more anxiety than necessary.

Further, as an improvement in view of the above problems, the inventors of the present application have disclosed an emulsion composition containing a mammalian salivary gland mucin, a water-soluble polyhydroxy compound, and an oil phase component, as disclosed in JP-A-61- No. 129038.

However, the conventional emulsion composition has a high pH value,
An emulsion composition which does not exhibit mild acidity suitable as a cosmetic and has sufficiently satisfactory physical properties for the skin could not be obtained.

[Means for solving problems]

In order to solve the above-mentioned problems, the present invention provides a highly safe surfactant system containing no surfactant,
(1) A gastric mucosa mucin of a mammal, a water-soluble polyhydroxy compound, and an oil phase component (the above is referred to as the first invention), and (2) the above first Oil-in-water consisting of the emulsion composition of the invention and the water phase component (O /
The present invention provides an emulsified composition characterized by being of the W type (the above is referred to as the second invention). The details will be described below.

First, the gastric mucosa mucin of mammals, which is one of the important substances of the present invention, is a glycoprotein (mucin) obtained from the gastric mucosa of mammals such as cows, horses, pigs, sheep, and other animals. It has unique viscosity depending on the type, and is extracted and purified from gastric mucosa mucin, which is a macromolecule containing sialic acid and having a molecular weight of 100,000 to 1,000,000. Examples thereof include cattle gastric mucin, horse gastric mucin mucin, pig gastric mucin mucin, sheep gastric mucin mucin, and other gastric mucosal mucins of all mammals such as dogs and cats. Furthermore, the gastric mucosa of these mammals can be used without any trouble in the present invention even if they are hydrolyzed with a proteolytic enzyme such as acid, alkali or protease. The gastric mucosa mucin used in the present invention is not limited to the above-exemplified animal as long as it is a mammal, and the animal species are different.
There is no problem even if two or more kinds are properly selected and mixed and used.

Next, the water-soluble polyhydroxy compound in the present invention is a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule, such as ethylene glycol, propylene glycol, 1,3-butylene glycol, 1,4-butylene. Glycol, hexylene glycol, diethylene glycol, dipropylene glycol or higher polyalkylene glycols, or glycerin, diglycerin, triglycerin or higher polyglycerins, or glucose, maltose, maltitol, sucrose, fructose , Xylitol, sorbitol, maltotriose, threitol or erythritol, or various invert sugars obtained by hydrolysis of starch, starch syrup, syrup, isomerized sugar, honey, jam, or glycerin, sugar Ethylene oxide, such as alcohol or saccharide (EO) or propylene oxide (PO)
One or a mixture of two or more selected from adducts and the like is not limited to the above-exemplified substances, and can be used without any particular problems as long as it is substantially water-soluble. The amount of such a water-soluble polyhydroxy compound is preferably 1 to 95% by weight of the final emulsified composition. This is because the effect of addition cannot be expected with a small amount of less than 1% by weight, and conversely, solubilization and emulsification become unstable with a large amount of more than 95% by weight, which is not preferable. The mixing ratio of the gastric mucosa mucin of mammals and the water-soluble polyhydroxy compound is 1: (2 to 2 by weight.
The range of 1000) is preferable. This is because when the mixing ratio of the water-soluble polyhydroxy compound is less than 2, it becomes difficult to dissolve the gastric mucosa of mammals, and when it is more than 1000, solubilization and emulsification become difficult. .

Further, the oil phase component in the present invention includes liquid or semi-solid (grease) hydrocarbons such as liquid paraffin, squalane, and vaseline, or octyldodecyl myristate, isopropyl palmitate, cetyl-2-.
Ester oils such as ethyl hexanoate, glyceryl-tri-2-ethylhexanoate, vitamin E acetate, vitamin A palmitate, vitamin C stearate, or solid paraffin, microcrystalline wax, ceresin wax, beeswax, Wax such as spermaceti, olive oil, cottonseed oil, soybean oil, safflower oil, rice bran oil, almond oil, jojoba oil, grape seed oil, apricot kernel oil and other vegetable oils, or mink oil, turtle oil, etc. Animal oil of or, higher alcohols such as cetanol, stearyl alcohol, cetostearyl alcohol, behenyl alcohol, oleyl alcohol, octyldodecanol, or lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid,
Higher fatty acids such as oleic acid, behenic acid, linoleic acid and linoleic acid, or silicone oils such as dimethyl silicone, methylphenyl silicone, cyclic silicone, etc., conventionally foods, cosmetics, quasi drugs, pharmaceuticals, toiletries. It is a component substance that is widely used in fields such as
One or more of these substances may be appropriately selected and used. The total amount of water-soluble polyhydroxy compound and mammalian gastric mucosa mucin used for such an oil phase component is 15% or more of the total amount from the viewpoint of system solubilization and emulsion stability. Is desirable.

As described above, it is not necessary to add a surfactant to the emulsified composition of the first invention composed of the gastric mucosa of mammals, the water-soluble polyhydroxy compound, and the oil phase component, but it is necessary to use the emulsion. According to, nonionic surfactants, anionic surfactants, amphoteric surfactants, cationic surfactants,
The combined use of synthetic or natural surfactants such as lecithin, sodium caseinate, and saponin does not impair the effects of the present invention, and various additives that have been widely used in the past, such as ultraviolet absorbers and antiseptic agents, are used. A bactericidal agent, an antioxidant, a medicinal substance, a flavoring agent, a coloring agent, a thickening agent composed of a water-soluble polymer, a stabilizer, and the like may be appropriately added. Then, this emulsion composition becomes a transparent or translucent viscous liquid or gel when homogenized by stirring or the like under normal temperature or conditions of heating to such an extent that the deterioration of each active ingredient does not occur. , For example, in the form of fortified food jelly, beauty essence, medicated jelly, etc., and can be used as it is in various fields such as food, cosmetics, external medicines, etc. can do.

Such an emulsion composition of the second invention is obtained by further adding an aqueous phase component to the emulsion composition according to the first invention, and the aqueous phase component at this time is a wetting agent in water, water-soluble vitamins, Water-soluble polymer, water-soluble drug, water-soluble antiseptic, ethanol, amino acids, and other water-soluble ingredients commonly used in conventional food, cosmetics, quasi-drugs, pharmaceuticals, toiletries, etc. The oil-in-water (O / W) type emulsion composition can be obtained by adding the above-mentioned aqueous phase component while stirring the emulsion composition according to the first invention. Here, the mixing ratio of the emulsion composition of the first invention and the aqueous phase component is not particularly limited, but in order to obtain an oil-in-water type emulsion (emulsion) having excellent stability, the weight ratio is It is desirable to be within the range of 0.1: 99.9 to 90:10. The oil-in-water type emulsion obtained here is a viscous or low-viscosity milky white liquid in which fine particles are uniformly dispersed, including nutritional drinks,
Cosmetics such as emulsion, cream or foundation,
Or, quasi-drugs, medicinal products such as external medicated skin agents
Alternatively, it is a suitable emulsified composition which can be widely used in various fields such as toiletry products such as shampoo, conditioner and treatment.

[Action]

In the emulsified composition of the present invention, mammalian gastric mucosa mucin having extremely high safety to the human body, that is, glycoprotein (mucin), which is a macromolecule containing sialic acid and having a molecular weight of 100,000 to 1,000,000, and water-soluble polyhydroxy The system composed of the compound exhibits an excellent surfactant action on the oil phase, and a solubilized liquid or an emulsion is obtained by this action. Furthermore, an aqueous phase component is added to such an emulsion composition. It was clarified that a milky white oil-in-water emulsion can be obtained by emulsification. This is because the above-mentioned glycoprotein (mucin)
And a water-soluble polyhydroxy compound form a quasi-polymer complex based on hydrogen bonds, etc., which becomes a continuous phase that exerts a surface-active effect, and the oil phase component is effectively solubilized in this continuous phase. It is considered that the oil phase component is made into ultrafine particles and included by adding an aqueous phase to this.

〔Example〕

Examples 1 to 6: Emulsion compositions prepared by mixing mammalian gastric mucosa mucin, water-soluble polyhydroxy compound and oil phase component in the proportions shown in Table 1 (% by weight, hereinafter the same) and mixing with a homomixer at room temperature. I got A. Furthermore, 90 parts by weight of water at room temperature was added to 10 parts by weight of this emulsion composition A with stirring to obtain an oil-in-water emulsion composition B. The obtained emulsified composition A was subjected to state observation, viscosity (cp) and pH measurement at 25 ° C., and the oil-in-water type emulsified composition B was emulsified particles after standing for 1 day after preparation. The diameter was measured.
The respective results obtained are shown in Table 2. All resulted in a stable, transparent or translucent viscous liquid or gel.

Comparative Examples 1 to 6: Mammalian gastric mucosa, water-soluble polyhydroxy compound and oil phase component in the proportions shown in Table 3 The same operations as in Examples 1 to 6 were carried out except that they were mixed to obtain an emulsified composition C and an oil-in-water emulsified composition D. Particles of the same observation as in Examples 1 to 6 for each of the obtained emulsion compositions, measurement of viscosity (cp) and pH at 25 ° C., and one day left after preparation of the oil-in-water emulsion composition D The diameter was measured and the results are summarized in Table 4.

As is clear from Tables 2 and 4, Comparative Examples 1-6
None of them were stable gels or emulsions in a uniform and dispersed state as in Examples 1 to 6.

Example 7: Phase 1 Porcine gastric mucosa mucin 2.0 (%) Sodium hyaluronate 0.1 Glycerin 40.0 Sorbitol (75%) 32.1 Phase 2 Vitamin E acetate 0.5 Avocado oil 10.0 Squalane 15.0 Preservative 0.2 Perfume 0.1 Each component at room temperature At the room temperature, the second phase at room temperature
The phases are added with stirring. This was applied to a homomixer to obtain emollient gel (cosmetic gel). The emollient gel was a transparent gel with a viscosity of 18500 cp at 25 ° C. and a pH of 5.69, which was highly safe and had an emulsified particle size of 1 μm or less and was extremely excellent in usability.

Example 8: Phase I Porcine gastric mucosa mucin 1.0 (%) Glycerin 15.0 1,3-Butylene glycol 5.0 L-Arginine (50% aqueous solution) 0.1 Phase II squalane 5.0 Jojoba oil 2.0 Natural vitamin E 0.2 Vitamin A palmitate 0.2 No. Three-phase carboxyvinyl polymer 0.1 Preservative 0.2 Purified water 71.2 At a temperature of 80 ° C., the first phase and the second phase were mixed in the same manner as in Example 7 to obtain an emulsion composition. This emulsified composition was diluted with a separately prepared third phase aqueous solution at 80 ° C. and cooled to room temperature. This was an oil-in-water emulsion having a viscosity (25 ° C.) of 1200 cp and a pH of 5.74, and the emulsion particle size of this emulsion was 2 μm or less, and the usability was very excellent.

Example 9: Phase 1 Porcine gastric mucosa mucin 3.5 (%) Glycerin 60.5 Purified water 3.0 Chlorhexidine gluconate (20%) 1.0 Phase 2 Vitamin E Acetate 2.0 Squalane 15.0 Octyldodecyl myristate 15.0 In a manner similar to Example 7. An emulsified composition was obtained from the first phase and the second phase. This was a gel composition having a viscosity (25 ° C.) of 34000 cp and a pH of 5.78, which was a stable external pharmaceutical skin external preparation having an emulsion particle size of 1 μm or less.

Example 10: Phase 1 Porcine Gastric Mucosa Mucin 3.5 (%) Sorbitol (70%) 35.0 Glycerin 35.0 Phase 2 Vitamin E Acetate 26.5 In the same manner as in Example 7, an emulsified composition was prepared from Phase 1 and Phase 2. Obtained. This is a water-soluble preparation of fat-soluble vitamin, which is a liquid composition with viscosity (25 ° C) of 10,000 cp and pH 5.72, which has an emulsion particle size of 1 μm or less and is extremely stable. It was extremely effective as an E acetate solution. When 1 part by weight of this emulsified composition was diluted to 99 parts by weight of water, it was easily stably dispersed and dissolved in water.

〔effect〕

As is clear from the above description, the emulsion composition of the present invention has an advantage that it exhibits a weak acidity suitable for cosmetics and has sufficiently preferable physical properties for skin. The emulsified composition of the present invention does not need to use the conventional emulsification method performed at a high temperature of about 80 ° C., and can be microemulsified at room temperature or at a temperature at which the oil phase component is uniformly dissolved. Therefore, there is no concern that high temperature deterioration will occur even when trying to add easily degradable medicinal components such as vitamins, and since it does not contain various conventional surfactants, it is anxiety for general consumers. It can be said that it is an extremely safe emulsion composition without causing a feeling. Further, in producing the emulsion composition of the present invention, it is preferable from the viewpoint of energy saving that the steps such as heating and cooling can be omitted or shortened, and the significance of the present invention is extremely large. it can.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification number Reference number within the agency FI Technical indication location A61K 9/107 B 47/36 H B01F 17/38 17/56 (72) Inventor Shigeo Aoyama Osaka Prefecture 2-51, Dosho-cho, Higashi-ku, Osaka, Iwase Coshua Co., Ltd. (72) Inventor, Yuji Shibayama, 2-51, Dosho-cho, Higashi-ku, Osaka-shi, Osaka (56) Reference: JP-A-59-98727 (JP, A)

Claims (2)

[Claims] 1. An emulsified composition containing a mammalian gastric mucosa mucin, a water-soluble polyhydroxy compound, and an oil phase component. 2. An oil-in-water (O / W) type comprising an emulsion composition containing a gastric mucosa of a mammal, a water-soluble polyhydroxy compound, and an oil phase component, and an aqueous phase component. An emulsified composition characterized.