JPH0435211B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention uses glycyrrhizin or its salt as an emulsifier, which is a naturally occurring crude drug that has corticoid action, detoxification action, anti-allergy action, and anti-peptic ulcer action, and is also known to be effective against acute and chronic dermatitis. An oil-in-oil emulsion composition of a polyhydric alcohol (hereinafter referred to as "oil-in-oil emulsion composition") obtained by containing a polyhydric alcohol, glycyrrhizin or its salt, an oil phase component, and water as necessary, is intended to be effectively used in cosmetics and pharmaceuticals. , simply referred to as emulsified composition),
The present invention also provides an oil-in-water emulsion composition obtained by adding an aqueous phase component to this emulsion composition. In recent years, much research has been conducted on emulsification, a large number of emulsifiers have been developed, and emulsification technology has made remarkable progress, and extremely stable emulsions are now widely used in all industries. However, in most of them, nonionic surfactants containing polyoxyethylene chains, anionic surfactants such as fatty acid soaps, cationic surfactants, and amphoteric surfactants are used as emulsifiers, and they are not safe for the human body. There are many things that are of concern. Therefore, the present inventors researched the development of emulsions with uniform and fine particles using natural substances with high stability in the human body as emulsifiers, and as a result, discovered a new emulsifying composition containing glycyrrhizin or its salt. Ta. That is, according to studies conducted by the present inventors, it exhibits excellent emulsifying power for oil phase components and produces a uniform and stable emulsion. That is,
Combine a polyhydric alcohol that does not dissolve in oil, glycyrrhizin or its salt, and water as necessary,
It has been discovered that by adding an oil phase component to these, an emulsion composition in which the oil phase component is solubilized or uniformly dispersed as a microemulsion in polyhydric alcohol or water can be obtained. The inventors have discovered that by adding these compounds, a stable oil-in-water emulsion composition in which fine particles are uniformly dispersed can be obtained, leading to the completion of the present invention. The emulsion composition obtained according to the present invention is a transparent or translucent viscous liquid or gel, and the oil-in-water emulsion composition with water added is an emulsion of milky white fine particles. The cause of these fine particles is thought to be that glycyrrhizin or its salt interacts with the polyhydric alcohol, and the oil phase components are efficiently encapsulated in the polyhydric alcohol or polyhydric alcohol aqueous solution. The polyhydric alcohol used in the present invention is a hydrophilic polyhydric alcohol having two or more hydroxyl groups in the molecule, such as ethylene glycol, propylene glycol, 1,3-butylene glycol, dipropylene glycol, glycerin, diglycerin, triglycerin, Polyglycerin such as tetraglycerin, glucose, maltose, maltitol sucrose, fructose, xylitol, inositol, pentaerythritol, sorbitol, maltotriol, threitol, erythritol,
These include starch decomposing sugar and starch decomposing sugar reducing alcohol, and the blending amount thereof is preferably 2 to 95 wt%. As the glycyrrhizin in the present invention, glycyrrhizin extracted from Raul licorice etc. is used, and
Substances that form salts include inorganic bases such as lithium hydroxide, sodium hydroxide, potassium hydroxide, cesium hydroxide, and ammonium hydroxide;
Basic amino acids such as arginine, lysine, histidine, ornithine, basic amines such as monoethanolamine, diethanolamine, triethanolamine, etc. are used, and the amount of neutralization may be arbitrary. Glycyrrhizin in the present invention also includes glycyrrhizinic acid, which is a raw material for cosmetics. The salt may not only be produced in advance, but may also be produced during the process of producing the emulsion composition. The weight ratio of glycyrrhizin or its salt to polyhydric alcohol is preferably 1:2 to 1000. When adding water as necessary to polyhydric alcohol and glycyrrhizin or its salt, the amount used is within a range that does not exceed 1/2 of the weight of the polyhydric alcohol, and the total amount
It is preferable that it is 10W/W% or less. Oil phase components include animal and vegetable oils and fats such as beef tallow, squalane, olive oil, and jojoba oil, hydrocarbons, mineral oils such as liquid paraffin, petrolatum, and esters such as isopropyl myristate, pentaerythritol tetra-2-ethylhexanate, and vitamin A acetate. Oils, silicones such as dimethyl silicone and methylphenyl silicone, and oils commonly used in the cosmetics, pharmaceutical, food, and other industries are used. It is desirable that the total amount used of the polyhydric alcohol, casein or its salt, and optionally the content of the oil phase component is 20 wt% or more. Depending on the intended use, nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants may be mixed and added. Further, water, alcohol, fatty acids, various water-soluble polymers, etc. may be added for the purpose of homogeneity stabilization, viscosity adjustment, etc. The emulsified composition obtained here is a uniform, transparent or translucent gel or viscous liquid, so it can be used as it is, for example, as sun care oil, beauty serum, jelly, medicated jelly, lubricating oil, etc., in foods, It can be suitably used in all fields such as cosmetics, medicine, and feed. Next, an emulsified composition containing the above-mentioned glycyrrhizin or its salt, a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule, an oil phase component, and optionally water is added to an oil-in-water composition containing an aqueous phase component. The type emulsion composition will be explained. To obtain the oil-in-water emulsion composition according to the present invention,
It can be obtained by gradually adding an aqueous phase component to the emulsified composition. In this case, it is of course preferable to perform homomixer treatment. The oil-in-water emulsion composition obtained here has extremely excellent stability. Regarding the quantitative relationship between the emulsifying composition and the aqueous phase components, it is possible to produce emulsions in a very wide range of proportions, and by diluting 5 to 80 parts of the emulsifying composition with 95 to 20 parts of the aqueous phase components. Fine particles are dispersed to prepare a stable oil-in-water emulsion composition. The aqueous phase components are commonly used aqueous phase components in the cosmetics, pharmaceutical, food, and other industries, such as wetting agents, water-soluble vitamins, water-soluble preservatives, water-soluble drugs, and water-soluble polymers, dissolved in water. be. The oil-in-water emulsion composition obtained here is a milky-white viscous or low-viscosity liquid in which uniform fine particles are dispersed, so it can be used as is or for homogeneity stabilization, viscosity adjustment, or medicinal efficacy. By adding higher alcohols, fatty acids, water-soluble polymers, drugs, and surfactants, we can improve the quality of cosmetics such as emulsions, creams, and foundations, toiletry products such as shampoo and conditioner, and urea. It can be suitably used in all fields such as medicines such as creams and foods such as mayonnaise. The present invention will be explained below using Examples and Comparative Examples. Examples 1 to 9, Comparative Examples 1 to 3 Glycyrrhizin salt, polyhydric alcohol, purified water and oil were blended in the composition and amounts shown in Table 1,
An emulsion composition was prepared by processing in a homomixer at 70°C. Additionally, this emulsified composition has 10%
An oil-in-water emulsion composition was prepared by adding twice the amount of water with stirring at room temperature. The states of the emulsified composition and oil-in-water emulsified composition were observed, and the results are shown in Table 1. Note that the numbers for each component are parts by weight. As is clear from the table, a stable transparent or translucent viscous liquid or gel was obtained, and a stable oil-in-water emulsion composition was also obtained.

[Table] Example 10 Aqueous cosmetic oil (wt%) (A) Glycyrrhizin monosodium 1.0 Glycerin 30.0 Dipropylene glycol 5.0 (B) Olive oil 30.0 Squalane 20.0 Jojoba oil 13.1 Vitamin E acetate 0.2 Vitamin A palmitate 0.2 Preservatives 0.2 Fragrance 0.3 Stir phase (A) thoroughly at 70℃, dissolve (B) at 70℃, add the amount to phase (A) with homomixer treatment, stir and cool, and prepare for water-based cosmetics. I got oil. This aqueous cosmetic oil was in the form of a viscous, transparent liquid, and had a highly safe and stable texture that spread easily. Example 11 Nutritional cream (wt%) (A) Glycerin 20.0 Pentaerythritol 5.0 Dipropylene glycol 5.0 Glycyrrhizin monoammonium 5.0 (B) Cetanol 5.0 Squalane 18.0 Cetyl iso-octanoate 2.0 Jojoba oil 4.0 Preservative 0.4 Fragrance 0.2 ( C) Purified water 34.4 Carboxymethylcellulose 1.0 According to the production method of Example 10, an emulsified composition was obtained from (A) and (B), and the temperature was adjusted to 70°C. Separately adjusted and maintained at 70°C, a carboxymethylcellulose aqueous solution (C) After dilution and dispersion, the mixture was cooled to obtain an oil-in-water emulsion nutritional cream. The hardness of this cream was 14 at 25° C., the emulsion particle size was 0.5 to 1 μm, and it was stable and had an excellent feel when used. Furthermore, the cream was expected to have medicinal effects due to glycyrrhizin monoammonium. Example 12 Hair cream (wt%) (A) Glycerin 10.0 1,3-butylene glycol 5.0 Glycyrrhizic acid 2.0 Potassium hydroxide 0.3 (B) Liquid paraffin 30.0 Methylphenyl silicone 5.0 Vaseline 5.0 Preservative 0.3 Fragrance 0.4 (C) Purification Water 41.7 Carboxyvinyl polymer 0.3 According to the manufacturing method of Example 11, a hair cream was obtained. This hair cream has a viscosity of 30℃, 5700cps,
The hair cream was stable, had an emulsified particle size of 0.5 to 2μ, had an excellent texture, and was expected to have medicinal effects.

Claims (1)

[Claims] 1 Glycyrrhizin or its salt and 2 in the molecule
A method for producing an oil-in-water emulsion composition obtained by further mixing an oil-in-water emulsion composition containing a water-soluble polyhydric alcohol having at least one hydroxyl group and an oil phase component with water.