JPH01111660A - Concentration preventive container - Google Patents

Abstract

PURPOSE:To prevent changes in the concentration of a solvent due to its evaporation by inserting a pipe in the solution within a liquid container with its end in intimate contact with the inner wall of a sealable opening provided at the upper part of the container. CONSTITUTION:A pipe is provided with a bottom at the lower end thereof and either the pipe bottom or the side wall adjacent the lower end thereof is provided with a hole in communication with the outside. Preferably, this hole is located below a first predetermined height and above a second predetermined height in the container. The second height refers to the liquid surface corresponding to that of the liquid in the minimum limit of the amount, with changes in the liquid concentration resulting from evaporation confined within such a limit as not to create hindrance to its practical application. This method prevents the liquid from being reduced by removal to such a small amount that changes in the liquid concentration resulting from evaporation cause hindrance to its practical application. It is important that the material of the pipe to be inserted in the solution does not affect the liquid composition, preferably flexible to retain the airtightness of the container opening and the size of the hole may be such as not to hinder the flow of the liquid on the removal of the liquid.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a container for storing a solution having a fixed composition and dispensing the same a plurality of times for use.

Specifically, it is a container for storing solutions such as standard solutions, calibrators, control solutions, and reference solutions that are frequently used in the field of analytical chemistry, particularly in the field of clinical chemistry testing.

[Prior art] In the field of analytical chemistry, especially in the field of clinical chemistry testing, analysis is often performed using a solution with a certain concentration as a standard.This standard solution includes standard solutions, calibration solutions, calibrators, and control solutions. , reference liquid, etc. In particular, in the case of commercial products, which are widely used routinely in the field of clinical chemistry testing and are often commercially available, such solutions are generally stored in vials with a pressure of 5 to 10 mN'.

Vials have a large opening area compared to their volume, so
Evaporation of the solvent due to repeated opening and closing of the lid to take out the liquid cannot be ignored.

It is a general rule that containers containing standard solutions, etc. are tightly capped before performing analysis operations, and the caps are removed only when they are taken out with a pipette, and then capped again after fractionation.

In general, the standard solution is taken out and used several thousand to several hundred times, but during this time it gradually evaporates and the concentration of the remaining solution becomes thicker. Work may be continued without plugging, in which case evaporation will proceed rapidly.

As a result, the concentration of the solution used as a reference for analysis increases, making it impossible to obtain accurate measurement results.

Biological body fluids (whole blood, plasma,
Quantitative analysis of target components (analytes) in cerebrospinal fluid, urine, saliva, etc.) requires high precision, but concentrating the reference solution will cause measurement errors, which is critical for analytical measurements. It may become a problem. In particular, Na”, K in blood
", CI-, and other electrolyte ion concentrations are maintained at homeostasis within a very narrow range in normal living organisms, and measurement errors pose an extremely serious problem in clinical diagnosis. There has been a need for an easy-to-use, inexpensive container that suppresses concentration.

If you want to reduce the concentration change in a normal bottle, you can reduce the inner diameter A of the liquid storage part of the bottle or make the stopper diameter B sufficiently small. However, reducing the inner diameter A of the bottle However, there is a limit when considering the stability of the container against overturning. Furthermore, there is a limit to reducing the diameter B from the viewpoint of ease of use.

[Technical Issue M to be Solved] In the present invention, a bottle of a conventionally used shape is used as a liquid container having an opening at the top that can be sealed tightly.
A technical problem is to prevent changes in the concentration of a liquid due to evaporation of the solvent without making it inconvenient to take out the liquid.

[Means for solving technical problems] In the present invention, by passing a tube tightly attached to the inside of the opening of a liquid container having an opening at the top that can be sealed tightly into the solution in the container, This makes it possible to sufficiently suppress evaporation of the solvent by using containers such as wide-mouthed bottles (for example, vials) that are conventionally used.

Said tube has a bottom at its lower end, and the bottom or side wall of the tube near its lower end is provided with a hole leading to the outside, which hole is located below a predetermined height within the container. The predetermined height corresponds to the height of the liquid level of the normally accommodated amount of liquid.

Preferably, the hole provided in the side wall near the bottom or lower end of the tube is located below a first predetermined height within the container and above a second predetermined height.
The second height is a liquid level that corresponds to the minimum amount of liquid within a range where concentration of the liquid by evaporation does not pose a practical problem. In this way, the liquid is prevented from being collected until the concentration of the liquid due to evaporation reaches such a small residual amount that it poses a practical problem.

[Deception of specific structure] It is important that the material of the tube passed through the above solution does not affect the liquid composition, and in order to maintain airtightness between it and the opening of the container, it must be flexible. More preferred materials that satisfy these conditions include Teflon resin, polyethylene, polyvinyl chloride, acrylic resin, and silicone rubber. Furthermore, if the shape of the upper end of the tube matches the shape of the opening of the container, it is convenient for the tube to be brought into close contact with the inner wall of the opening. It goes without saying that the lid must remain tightly closed even after the tube is inserted.

When the container is a general cylindrical shape, the shape of the tube is preferably cylindrical in order for the upper end or the vicinity of the upper end to come into close contact with the opening of the container.The diameter of the cylindrical tube may be uniform, or it may have a length. The thickness of the tube wall may be uniform along its length, which may vary in part or throughout the length;
It may vary in part or throughout the length.

A typical example of the shape of the tube is shown in FIG.

The upper end or the vicinity of the upper end of the tube is brought into close contact with the opening of the container on the outside or inside to the extent that airtightness can be maintained.

It may be directly attached to the opening of the container body, or it may be indirectly attached to the opening of the container body through another suitable member that is tightly attached to the opening of the container body to the extent that airtightness can be maintained.

The size of the hole provided in the bottom of the tube or the side wall near the lower end should be large enough so that the flow of the liquid is not obstructed when taking out the liquid. Preferably, this prevents the tip of a liquid collection device, such as a pipette, from penetrating below the bottom of the tube, and also avoids damage to the tip of the pipette. When holes are provided in the side wall, they are preferably in contact with the bottom of the tube, so that no part of the liquid remains at the bottom of the tube after liquid collection.

Some examples of containers of the present invention are shown in FIG.
C is a case where the cylindrical tube is in close contact with the inside of the opening of the container near the top end, and C is a case where the cylindrical tube is in close contact with the outside of a member provided closely inside the opening of the container at the inside of the top end. A and B have a hole in the side wall near the bottom end of the tube, and C has a hole located off-center at the bottom of the tube.

[Example] A conventional glass vial (opening inner diameter 10+UA: main body inner diameter 23mm: height 5°-) is made of polyvinyl chloride and has a closed lower end (outer diameter 1U).
ss: inner diameter 8 mm: length 45+am> was inserted as shown in FIG. 1A. A hole with a diameter of 3 mm was provided in the bottom of the tube close to the III wall. By doing so, the area of the contained solution in direct contact with the outside air was approximately 178, and the evaporation rate was extremely slow. In other words, when a 10-1 reference solution was added, the cap was opened once a day, and 50 μl was taken out, 3
The concentration changes after 0, 100, and 160 days were as shown in Table 1 with and without the cylindrical tube inserted (concentration units are milligrams per liter).
.

Table 1 It can be seen from Table 1 that when the container of the present invention is used, no change in the concentration of the solution in the container is observed until 100 samples are taken, unlike conventional containers. Liquid sampling can be continued until the 160th time, when the effect of concentration due to evaporation is negligible.

Although the above-mentioned example relates to a reference solution for an ion-selective electrode, the present invention is not limited thereto, and includes standard solutions and calibrators in clinical chemistry tests, and the concentration of the contents of a container due to evaporation. This is useful when you want to avoid changes.

[Brief explanation of the drawing]

No. 111Z is a sectional view showing a specific example of the container of the present invention. FIG. 2 is a plan view and a sectional view showing examples of various cylindrical tubes. FIG. 3 is a sectional view showing a conventional liquid container. The meanings of the symbols in Figures 1 and 3 are as follows. 1: Container body 1a: Male threaded part 2; Lid 2a: Female threaded part 3: Packing 4: Liquid 5: Cylindrical tube 6: Hole Applicant Fuji Photo Film Co., Ltd. Figure 1A Figure 2B 'C Figure 3

Claims (4)

[Claims] (1) A liquid container having an opening in the upper part that can be sealed tightly, and having a tube whose open upper end or the vicinity of the upper end is in close contact with the inside of the opening to the extent that substantially no ventilation occurs; A liquid container characterized in that it has a bottom at its lower end and a hole leading to the outside in the bottom of the tube or in the side wall near the bottom end, said hole being located below a predetermined height within the container. (2) When the above solution is chemically analyzed in a clinical chemistry test,
Claim (1) which is a solution used as a standard
Container as described. (3) The container according to claim (1), wherein the upper end of the tube or the outer surface near the upper end is in close contact with the inner surface of the opening of the container. (4) The hole provided in the side wall near the bottom or lower end of the tube is located below a predetermined first height within the container and above a predetermined second height within the container. Container according to claim (1), characterized in that: