JPH01111657A - Concentration preventive container - Google Patents

Abstract

PURPOSE:To prevent the evaporation of a solvent and the accompanying change in its concentration, by bringing the outer surface of a pipe near the upper end thereof into contact with the inner surface of the opening portion of a liquid container to such an extent as to substantially cause airtightness and by positioning the lower end of the pipe below a predetermined height of the interior of the container. CONSTITUTION:A pipe 5 in intimate contact with the inner wall of an opening portion which is sealable with a lid 2 and which is provided on the upper part of a liquid container 1 is inserted in a solution 4 of the container 1 with the lower end of the pipe 5 positioned below a predetermined height of the interior of the container. This height is smaller than that of the liquid initially accommodated in the container and selected appropriately from the amount of the liquid to be stored therein. The material of the pipe inserted into the liquid does not affect the liquid composition, preferably flexible to retain the airtightness of the container opening and, if the container is cylindrical, it is desired that the shape of the pipe be cylindrical for the intimate contact of its upper part or the adjoining portion with the container opening. This permits the area of direct contact of the solution with the external air to be reduced, so long as the pipe end reaches the liquid surface, extremely reducing the evaporation rate and accordingly preventing changes in the concentration.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a container for storing a solution having a fixed composition and dispensing the same a plurality of times for use.

Specifically, it is a container for containing solutions called standard solutions, standard solutions, calibrators, control solutions, reference solutions, etc., which are frequently used in the field of analytical chemistry, particularly in the field of clinical chemistry testing.

[Prior art] In the field of analytical chemistry, especially in the field of clinical chemistry testing, analysis is often performed using a solution of a certain concentration as a standard.This standard solution includes standard solutions, control solutions, reference solutions, etc. There is something called. In the case of commercially available products, which are widely used in the field of clinical chemistry testing and are often commercially available, such solutions are generally stored in vials with a pressure of about 5 to 10 mZ. Since the opening area of a vial is large compared to its volume, evaporation of the solvent cannot be ignored due to repeated opening and closing of the lid to take out the liquid.

It is a general rule that containers containing standard solutions, etc. are tightly capped before performing analysis operations, and the caps are removed only when they are taken out with a pipette, and then capped again after fractionation.

In general, the standard solution is taken out and used several thousand to several hundred times, but during this time it gradually evaporates and the concentration of the remaining solution becomes thicker. Work may be continued without plugging, in which case evaporation will proceed rapidly.

As a result, the concentration of the solution used as a reference for analysis increases, making it impossible to obtain accurate measurement results.

Biological body fluids (whole blood, plasma,
Quantitative analysis of target components (analytes) in cerebrospinal fluid, urine, saliva, etc.) requires high precision, but concentrating the reference solution will cause measurement errors, which is critical for analytical measurements. It may become a problem. In particular, the concentration of electrolyte ions such as Na'', Ni', and C1- in the blood is maintained at homeostasis within a very narrow range in normal living bodies, and measurement errors pose an extremely serious problem in clinical diagnosis. Against this background, there has been a need for an easy-to-use, inexpensive container that can suppress concentration caused by evaporation of the solvent.

In order to reduce the concentration change in a normal bottle, it is sufficient to reduce the inner diameter A of the liquid storage part of the bottle or to make the aperture B of the stopper sufficiently small. However, reducing the inner diameter A of the bottle There is a limit to stability against rotation. There is also a limit to reducing the aperture B in terms of ease of use.

[Technical Problems to be Solved] In the present invention, a bottle of a conventionally used shape is used as a liquid container having an opening at the top that can be sealed tightly.
A technical problem is to prevent the evaporation of the solvent and the resulting change in the concentration of the liquid without making it inconvenient to take out the liquid.

[Means for solving technical problems] In the present invention, by passing a tube tightly attached to the inside of the opening of a liquid container having an opening at the top that can be sealed tightly into the solution in the container, By using conventionally shaped bottles (e.g. vial bottles),
This makes it possible to sufficiently suppress concentration of the liquid due to evaporation of the solvent. The lower end of the tube is located below a predetermined height within the container.

The predetermined height is a height that is selected as appropriate from the range of the liquid level within the range of the amount of liquid normally stored and used, which is usually below the level of the amount of liquid to be initially stored. .

[Details of specific configuration] It is important that the material of the tube passed through the above solution does not affect the liquid composition, and in order to maintain airtightness between it and the opening of the container, it is especially important that it is flexible. preferable. Examples of materials that meet these conditions include acrylic resin, Teflon resin, polyethylene, polypropylene, polyvinyl chloride, silicone rubber, other synthetic rubbers, and vulcanized natural rubber. Furthermore, if the shape of the upper end of the tube matches the shape of the opening of the container, it is convenient for the tube to be brought into close contact with the inner wall of the opening. Needless to say, the lid must remain tightly closed even after insertion.

When the container is a general cylindrical shape, the shape of the tube is preferably cylindrical in order for the upper end or the vicinity of the upper end to come into close contact with the opening of the container.The diameter of the cylindrical tube may be uniform, or it may have a length. The thickness of the tube wall may be uniform along its length, which may vary in part or throughout the length;
It may vary in part or throughout the length.

A typical example of the shape of the tube is shown in FIG. The position of the lower end of the tube is, for example, 1/30 to 1/2 of the height of the liquid storage portion of the container.

The upper end or the vicinity of the upper end of the tube is brought into close contact with the opening of the container on the outside or inside to the extent that airtightness can be maintained.

It may be directly attached to the opening of the container body, or it may be indirectly attached to the opening of the container body through another suitable member that is tightly attached to the opening of the container body to the extent that airtightness can be maintained.

Some examples of containers of the present invention are shown in FIG. 1, A is a case where the cylindrical tube fits tightly inside the opening of the container at the upper end, and B is a case where the cylindrical tube fits tightly inside the opening of the container near the upper end. In this case, C is a case where the cylindrical tube is in close contact with the outside of the relay member provided inside the opening of the container on the inside of the upper end.

[Example] A conventionally used glass vial (rM mouth inner diameter LoI: main body inner diameter 23 mm: height 50 mm)
Pour oTa1 reference solution, then add a cylindrical tube made of polyvinyl chloride (outer diameter 1oss: inner diameter 8+me+: length 401)
inserted.

By doing this, while the tip of the tube reached the liquid level, the area of the solution in direct contact with the outside air was reduced to about 1/8, and the evaporation rate was extremely slow. In other words, open the bottle once a day and drink 5
30 days, 60 days and 10 days when 0 μl was taken out.
The concentration changes after 0 days were as shown in Table 1 for the cases with and without the 5-cylindrical tube inserted (the unit of concentration is milligram 1 ridge/1).

(Go to next page) Table 1 It can be seen from Table 1 that when the container of the present invention is used, the change in the concentration of the solution in the container is much smaller than that of a conventional container.

The example described above is for reference solutions for ion-selective electrodes, but is not limited to this, and can also be used to avoid changes in the concentration of the contents of containers due to evaporation, such as standard solutions and calibrators for other clinical chemistry tests. Useful if you want to.

[Brief explanation of the drawing]

FIG. 1 is a sectional view showing a specific example of the container of the present invention. FIG. 2 is a plan view and a sectional view showing examples of various cylindrical tubes. FIG. 3 is a sectional view showing a conventional liquid container. The meanings of the symbols in Figures 1 and 3 are as follows. 1: Container body 1a: Male threaded portion 2; Lid 2a: TFI threaded portion 3: Packing 4: Liquid 5: Cylindrical tube Applicant: Fuji Photo Film Co., Ltd. Figure 1

Claims (6)

[Claims] (1) A liquid container having an opening in the upper part that can be sealed tightly, and having a tube whose open upper end or the vicinity of the upper end is in close contact with the inside of the opening to the extent that substantially no ventilation occurs; A liquid container characterized in that the open lower end of the liquid container is located below a predetermined height within the container. (2) The container according to claim (1), wherein the upper end or the outer surface of the vicinity of the upper end of the tube is in close contact with the inner surface of the opening of the container. (3) The container according to claim (1), wherein the cross-sectional shape of the tube is similar to the cross-sectional shape of the opening of the container. (4) The container according to claim (1), wherein the tube is made of a material that does not affect the liquid composition. (5) The container according to claim (1), wherein the solution is a solution used as a standard during chemical analysis. (6) Claims (1) wherein the solution is a solution used as a standard for chemical analysis in clinical chemistry tests;
) Containers listed.