JP7158969B2 - Organic probes and molecular detectors - Google Patents

Description

Embodiments relate to organic probes and molecular detection devices.

Household water heaters are equipped with a device that detects carbon monoxide, which is generated when incomplete combustion occurs, and alerts you to danger at an early stage. Such gas components have a serious effect on the human body. According to the guidelines of the LP Gas Safety Commission, a carbon monoxide concentration of about 200 ppm (one part per million) causes a headache. Various methods are known for detecting relatively high-concentration gas components. methods are limited.

At disaster sites and sites where acts of terrorism have taken place, it is required to sense danger in advance by detecting extremely small amounts of gas components. Very low-concentration gas components are often detected using large equipment in research facilities. In such cases, expensive, heavy and bulky stationary equipment such as gas chromatographs and mass spectrometers are required. From this point of view, a device capable of detecting extremely low-concentration gas components in real time, that is, it is small in weight and volume and excellent in portability, and can selectively detect extremely low-concentration gas components on the order of ppt to ppb. There is a demand for a detection device capable of detecting both in a simple and highly sensitive manner.

Those who primarily orchestrate terrorism and carry home-made explosives carry out terrorism by involving civilians, called soft targets. Therefore, there is a need for a detection device that is highly effective, compact, and highly portable in crowded places such as airports, train stations, and exhibition halls. Constantly visible vigilance can have a high deterrent effect.

Explosives emit a small amount of volatile explosive components even when sealed, and it is common at airports and other sites to detect this with a trained police dog or other detector. This is highly effective from a deterrence standpoint, but animal-based coping methods are expensive and difficult to consistently ensure accuracy.

In order to realize a portable detection device with high detection accuracy, a target is detected by forming a charge-transfer complex between an aromatic nitro component on a nanotube or nanowire and an amine component surface-modified on the detection surface. A method to do so is proposed.

In addition to explosives, the above detection method can also detect poisonous substances such as sarin, emission components of electronic cigarettes such as formaldehyde, and drugs such as stimulants seized by customs. Such objects float in the air at low concentrations of about ppm to ppb. Public facilities such as train stations and airports are required to quickly detect these objects and prevent illegal drugs from being brought in, for example.

International Publication No. 2011/154939

The problem to be solved by the present invention is to selectively detect extremely low-concentration gas components with high sensitivity.

An organic matter probe of an embodiment includes a first organic matter probe and a second organic matter probe. Each of the first and second organic probes has a head portion having a purine structure, a pyrimidine structure, or a triazine structure, a base portion that bonds to the substrate, and a bonding portion that connects the head portion and the base portion. and an organic compound having The base portion has a monovalent polycyclic aromatic hydrocarbon group. The first organic probe and the second organic probe are combined. The second organic probe has a structure different from that of the first organic probe.

It is a block diagram which shows a molecule|numerator detection apparatus. FIG. 4 is a block diagram showing another example of a molecule detection device; It is a figure which shows the structure of the detector in a molecule|numerator detection apparatus. FIG. 4 is a diagram showing an example of a waveform detected by a molecule detection device; FIG. 4 is a diagram showing an example of multiple detection cells in a molecule detection device; FIG. 10 is a diagram showing an example of detection results of an object by a plurality of detection cells; FIG. 4 is a diagram showing an example of an organic compound used for an organic matter probe; FIG. 10 is a diagram showing another example of a detection element; It is a figure which shows the information processing part in a molecule|numerator detection apparatus.

Hereinafter, embodiments will be described with reference to the drawings. In addition, in each embodiment, the same code|symbol may be attached|subjected to the substantially same component part, and the description may be partially abbreviate|omitted. The drawings are schematic, and the relationship between the thickness of each part and the planar dimensions, the ratio of the thickness of each part, and the like may differ from the actual constituent parts.

FIG. 1 is a block diagram showing the molecule detection device of the embodiment. A molecule detection device 1 shown in FIG. 1 is a device for detecting target molecules 2 from, for example, a target gas 3 generated from a gas source, and includes a detector 10 and a discriminator 20 . A target gas 3 containing target molecules 2 is first sent to the detector 10 of the molecular detection device 1 . Here, the target gas 3 may contain substances having similar molecular weights and molecular structures to the target molecules 2 as impurities. Further, as shown in FIG. 2, the target molecules 2 floating in the air are often present in a state of being mixed with various contaminants 4 (4a, 4b) such as odor components and fine particles. From this point of view, as shown in FIG. 2, the target gas 3 may be pretreated by a filter device 5, a molecule distribution device 6, or the like, and then sent to the detector 10 of the molecule detection device 1. FIG.

A general medium-high performance filter or the like is used for the filter device 5 of the pretreatment device. Particulate matter such as fine particles contained in the target gas 3 is removed by the filter device 5 . The target gas 3 from which particulate matter has been removed by the filter device 5 is sent to the molecule distribution device 6 . As the molecular distribution device 6, the target gas 3 is ionized into an ionized substance group, a voltage is applied to the ionized substance group, and the ionized substance group is caused to fly at a speed proportional to the mass, and the flight speed due to this mass difference and the flight time based thereon are used. As an example, an apparatus for separating the ionized substance of the target molecule 2 from the ionized substance group is exemplified. As such a molecule distribution device 6, a device including an ionization section, a voltage application section, and a time-of-flight separation section is used.

A target gas 3 containing target molecules 2 is directed to a detector 10 either directly or after being pretreated in a device such as a filter device 5 or a molecule distribution device 6 . The detector 10 has a detection surface partitioned into a plurality of detection cells 101, as shown in FIG. Although FIG. 3 shows a state in which the detection surface 10A of the detector 10 is arranged facing the end portion 6a of the molecule distribution device 6, the arrangement of the detector 10 is not limited to this. A plurality of detection cells 101 each comprise a sensor 11 and a detection element 13 having an organic probe 12 attached to the sensor 11 . FIG. 3 shows a sensing element 13 using a graphene field effect transistor (GFET) for the sensor 11 . The sensor 11 is not limited to a GFET, and may be a field effect transistor using carbon nanotubes, a surface acoustic wave sensor, or the like.

The GFET includes a semiconductor substrate functioning as a gate electrode 14, an insulating film functioning as a gate insulating layer 15 on the gate electrode 14, and a graphene layer 16 functioning as a channel forming region on the gate insulating layer 15. , a source electrode 17 provided at one end of the graphene layer 16 , and a drain electrode 18 provided at the other end of the graphene layer 16 . An organic substance probe 12 is provided on the graphene layer 16 . An organic compound that selectively binds to the target molecule 2 is used for the organic substance probe 12 . The target molecules 2 guided to the detector 10 are captured by the organic substance probes 12 on the graphene layer 16 . Some impurities do not interact with the organic substance probe 12 and are not captured by the detection element 13 . Electrons are transferred from the target molecule 2 captured by the organic substance probe 12 to the GFET, thereby performing electrical detection. Thereby, the target molecule 2 of interest is selectively detected.

Since the organic matter constituting the organic matter probe 12 has a property of being dissolved in a solvent, the organic matter probe 12 can be placed on the graphene layer 16 by applying the solution dissolved in the solvent. The organic matter probe 12 preferably has a site having a structure such as a pyrene ring in order to facilitate interaction with graphene. A molecule having a structure like a pyrene ring interacts with a hexagonal π-electron system composed of graphene carbons, forming an interaction state called π-π stacking. When a low-concentration probe molecule is dissolved in a solvent and applied to graphene, π-π stacking is formed between the pyrene rings and the graphene, and the probe molecules are aligned and immobilized on the graphene. The organic substance probe 12 can be placed on the graphene layer 16 using such a self-arrangement action. The organic compound that constitutes the organic matter probe 12 will be described in detail later.

When the target molecule 2 is captured by the organic substance probe 12 provided on the graphene layer 16, the output of the GFET changes. Electricity continues to flow normally between the source electrode 17 and the drain electrode 18 because there is a zero gap when the graphene is a single layer. When the number of layers of graphene increases to two or three layers, a bandgap occurs, but the bandgap is relatively smaller in the actual system than expected from the strict theoretical values. When the gate insulating layer 15 has a dielectric constant similar to that of a silicon oxide film, electricity often continues to flow between the source electrode 17 and the drain electrode 18 . Therefore, the graphene layer 16 is not limited to a graphene single-layer structure, and may be composed of a graphene laminate of about five layers or less.

The target molecule 2 flying near the organic substance probe 12 is attracted to the organic substance probe 12 by the force of hydrogen bonding, and in some cases comes into contact with the organic substance probe 12 . When the target molecule 2 contacts, electrons are exchanged with the organic probe 12, and an electrical change is transmitted to the graphene layer 16 with which the organic probe 12 is in contact. The electrical change transmitted from the organic matter probe 12 to the graphene layer 16 disturbs the electrical flow between the source electrode 17 and the drain electrode 18 , so the GFET functions as the sensor 11 .

According to the GFET using the graphene layer 16, even a very small electrical change appears as an output remarkably. Therefore, a highly sensitive detection element 13 can be configured. In the sensor 11 using a GFET, since graphene has properties as a zero-gap semiconductor, there is a tendency for current to flow between the source electrode 17 and the drain electrode 18 even if no voltage is applied to the gate electrode 14 . Although the sensor 11 functions as it is, normally, a current is passed between the source electrode 17 and the drain electrode 18 with a voltage applied to the gate electrode 14, and the gate electrode when the target molecule 2 is captured by the organic substance probe 12. 14 electrical changes are observed.

FIG. 4 shows an example of detection waveforms of target molecules 2 by the molecule detection device 1 . When the organic substance probe 12 captures the target molecule 2, the detected waveform changes as shown in FIG. Various methods are conceivable for converting the detected waveform into signal intensity. For example, a value calculated from the areas of P1 and P2 in FIG. 4 and P3, which is the tip of the peak, is set as the intensity. However, it is not necessarily limited to this method.

In the detection of the target molecule 2 by the detection element 13 described above, the higher the transfer of electrons from the target molecule 2 captured by the organic substance probe 12 to the GFET, the higher the function of the sensor 11 becomes. The sensor 11 using a GFET is considered to be the most sensitive FET sensor, and can improve the sensitivity by about three times compared to a sensor using a carbon nanotube. Therefore, by using the detection element 13 in which the GFET and the organic substance probe 12 are combined, the target molecule 2 can be detected with high sensitivity.

FIG. 5 shows a hexagonal grid sensor in which the detection surface 10A of the detector 10 is divided into six detection cells: detection cell A, detection cell B, detection cell C, detection cell D, detection cell E and detection cell F. ing. At least some of the detection cells A to F are provided with organic probes 12 of different types, that is, a plurality of organic probes 12 having different binding strengths with the target molecule 2 . Each of the plurality of organic probes 12 interacts with the target molecule 2, but has different bonding strength with the target molecule 2, so that detection signals with different intensities are output. The detection signals from the detection cells A to F have different signal intensities depending on the bonding strength of the organic matter probe 12 with the target molecule 2 .

Signals detected by detection cells A to F are sent to discriminator 20 for signal processing. The discriminator 20 converts the detection signals from the detection cells A to F into intensities, and analyzes signal patterns based on the intensity difference of these detection signals (for example, six detection signal patterns shown in FIG. 6). The discriminator 20 stores signal patterns corresponding to substances to be detected. By comparing these signal patterns with the signal patterns detected by the detection cells A to F, the object detected by the detector 10 can be identified. Identification of molecule 2 is performed. Such signal processing is referred to herein as a pattern recognition method. According to pattern recognition methods, target molecules 2 can be detected and identified by means of object-specific signal patterns, for example fingerprint inspection. Therefore, extremely low-concentration gas components (target molecules 2) on the order of ppt to ppb can be detected selectively and with high sensitivity.

By applying the pattern recognition method described above, target molecules 2 can be selectively and highly sensitively detected and identified even when impurities are mixed in the target gas 3 guided to the detector 10. can. For example, when the target molecule 2 is dimethyl methylphosphonate (DMMP, molecular weight: 124), which is a representative material of a toxic organophosphorus compound, pesticides having phosphoric acid such as dichlorvos, which has a similar chemical structure, malathion, Organophosphorus pesticides, such as chlorpyrifos and diazinon, are often used. In order to prevent erroneous detection of these substances, it is effective to identify them by signal patterns as shown in FIG. That is, since the signal patterns detected by the detection cells A to F differ depending on the substances described above, by applying the pattern recognition method, even if impurities with similar molecular weights and similar constituent elements are mixed, A substance to be detected can be detected selectively and with high sensitivity. Even when the target molecule 2 is N-methyl-2-phenylethylamine (NMPA, molecular weight: 135), which is a representative material of a compound similar to the illegal drug methamphetamine, DMMP can be obtained by selecting an appropriate organic substance probe. Identification by the signal pattern is possible in the same way as in .

Next, the organic substance probes 12 used in the plurality of detection cells A to F of the molecular detection device 1 will be explained. FIG. 7 is a diagram showing an example of an organic compound that constitutes an organic substance probe. FIG. 7 shows organic compounds 100A-100F. The organic compound 100A has a 1,1,1,3,3,3-hexafluoro-2-phenyl-2-propanol structure. Organic compound 100B has a thianuric acid structure. Organic compound 100C has a thymine (T) structure. Organic compound 100D has an adenine (A) structure. Organic compound 100E has a cytosine (C) structure. Organic compound 100F has a guanine (G) structure.

The organic compound 100A has a hydroxyl group (--OH) and an amino group (--NH) as reactive groups with respect to the target molecule 2. FIG. On the other hand, when the target molecule 2 is a drug such as an illicit drug or an illegal drug, and particularly contains an amine derivative compound such as amphetamine or methamphetamine, which are stimulant components, the hydroxy group (--OH) or amino group (--NH) Organic compounds having an amide group (-NH-C=O) instead are preferred. The amide group interacts with the amine group of the amine derivative compound. In particular, an organic compound having a cyclic amide structure has a high action effect with an amine group of an amphetamine structure or a methamphetamine structure, and can capture amphetamine or methamphetamine well. Therefore, the tianuric acid structure, the thymine (T) structure, the cytosine (C) structure, and the guanine (G) structure are suitable for detection of target molecules 2 having amine derivative compounds.

The configuration of the organic matter probe 12 will be further described. The organic substance probe 12 includes a head portion HS, a base portion BS that serves as an installation site for the graphene layer 16 and the like, and a joint portion CS that joins the head portion HS and the base portion BS.

As described above, the head portion HS has a purine structure such as an adenine (A) structure or a guanine (G) structure, a pyrimidine structure such as a thymine (T) structure or a cytosine (C) structure, or a triazine structure such as a cyanuric acid structure. is preferred. Adenine (A) structure or guanine (G) structure has a carbonyl group or an amine group. A thymine (T) or cytosine (C) structure has a carbonyl group and an amine group. A cyanuric acid structure has a carbonyl group and an amine group. When having a purine structure, a pyrimidine structure, or a triazine structure, the organic matter probe 12 is preferably in a dry state.

Base part BS is preferably a monovalent substituted or unsubstituted polycyclic aromatic hydrocarbon group having a polycyclic structure such as pyrene ring, anthracene ring, naphthacene ring, phenanthrene ring, etc. A pyrene group is more preferred.

The bond CS is a single bond or a double bond (divalent group) and may be an alkyl group or an alkylene group, but an ether bond (-O-), an ester bond (-C(=O)O- ), carbonyl bond (--CO--), amide bond (--NH--CO--), imide bond (--CO--NH--CO--), and the like. The bond CS of the organic compound 100A has a (—NH—CO—C ₄ H ₈ —) group. Bond CS of organic compound 100B has a (—C ₆ H ₁₂ —) group. The bond CS of organic compounds 100C-F has a (--C ₅ H ₁₀ --O--C ₂ H ₄ --) group.

The base portion BS is bonded to a substrate such as the graphene layer 16, for example. Base part BS is preferably a monovalent substituted or unsubstituted polycyclic aromatic hydrocarbon group having a polycyclic structure such as pyrene ring, anthracene ring, naphthacene ring, phenanthrene ring, etc. A pyrene group is more preferred. The base portion BS of organic compounds 100A-100F has a pyrene group.

An organic substance probe 12 having a purine structure, a pyrimidine structure, or a triazine structure may be bound to another organic substance probe 12 . FIG. 8 is a diagram showing another example of the detection element 13. As shown in FIG. Note that the configuration of the sensor 11 is the same as the configuration of the detection element 13 shown in FIG. 3, so the description of FIG. 3 is used as appropriate.

The detection element 13 shown in FIG. 8 has an organic probe 12a and an organic probe 12b coupled to the organic probe 12a. The organic substance probe 12a and the organic substance probe 12b are bonded by a chemical bond such as a hydrogen bond.

Examples of the combination of the organic probe 12a and the organic probe 12b include the combination of the organic probe 12a having a purine structure and the organic probe 12b having a pyrimidine structure bonded to the purine structure by hydrogen bonding, and the organic probe having a triazine structure. A combination of 12a and an organic substance probe 12b having a purine or pyrimidine structure bonded to the triazine structure by hydrogen bonding, and an organic substance probe 12a having a triazine structure and an organic substance probe having a triazine structure bonded to the triazine structure by hydrogen bonding. 12b, and the like. In addition, it is not limited to this, and three or more kinds of organic matter probes 12 may be combined.

A combination of an organic substance probe 12a having a thymine structure (T) and an organic substance probe 12b having an adenine (A) structure, a combination of an organic substance probe 12a having a cytosine (C) structure and an organic substance probe 12b having a guanine structure (G). form a pair structure that stabilizes by binding to each other, similar to the base sequence of deoxyribonucleic acid (DNA).

An organic substance probe 12a and an organic substance having a pair structure (TA structure) of thymine (T) structure and adenine (A) structure or a pair structure (CG structure) of cytosine (C) structure and guanine (G) structure When the probe 12b comes into contact with the target molecule 2, the bonding state with the target molecule 2 changes from that of the organic substance probe 12 alone, and the polarization change of the probe itself also differs. In addition, when the target molecule 2 is positioned between the organic probe 12a and the organic probe 12b, and the bond between the probes is cleaved due to interference with the target molecule 2, the organic probe 12 alone does not separate from the target molecule 2. The binding state changes and the polarization change of the probe itself is also different. As a result, it is possible to obtain a different signal pattern than when the organic substance probe 12 is used alone, so that the types of signal patterns for identifying the target molecule 2 can be increased. In addition, for example, when one of the organic probes 12a and 12b interacts with the target molecule 2, the polarization state of the other probe also changes, so that the detection sensitivity can be improved more than when the organic probe 12 is used alone. can be done.

The detection and identification results of the target molecule 2 obtained by the molecule detection device 1 may be transmitted via an information network and utilized. FIG. 9 includes an information processing unit 30 having at least one selected from a function of transmitting detection information of the target molecule 2 via an information network and a function of collating the detection information with reference information obtained from the information network. An internal molecular detection device 1 is shown. The information processing section 30 includes an information transmission section 31 that transmits detection information of the target molecule 2, an information reception section 32 that receives reference information, and an information collation section 33 that collates the detection information with the reference information. . The information processing section 30 may have only one of the information transmission function and the information reception and collation function.

The detection information of the target molecule 2 is transmitted from the information transmission unit 31 through the network N to the information user. Also, in order to compare the detection information of the target molecule 2 with existing reference information, the information receiving unit 32 acquires the reference information via the network N. FIG. The acquired reference information is collated with the detected information by the information collating section 33 . By obtaining information from the external network N and referring to it, the function of carrying around and analyzing a large amount of information can be substituted for the outside, so that the molecular detection device 1 can be miniaturized and improved in portability. Furthermore, by using the network N, new signal patterns in the pattern recognition method can be acquired immediately. On the receiving side of the information, the next action can be taken based on this information. The portable molecular detection device 1 can be placed in various places, and the obtained data can be collected from various places and analyzed to be useful for evacuation guidance in an abnormal situation. By connecting the network N and the molecular detection device 1, many usages that could not be achieved in the past are created, and the industrial value is improved.

According to the molecule detection device 1 of the embodiment, it is possible to selectively detect extremely low-concentration gas component molecules on the order of ppt to ppb with high sensitivity. Furthermore, by increasing the detection sensitivity and detection accuracy with the detector 10 and the discriminator 20, the size of the molecule detection device 1 can be reduced. Therefore, it is possible to provide the molecule detection device 1 that achieves both portability and detection accuracy. The molecular detection device 1 of the embodiment can effectively exhibit its function when detecting drugs such as stimulants.

(Example 1)
A detection element combining a GFET and an organic substance probe was prepared as follows. A graphene layer can be formed by transferring it to a substrate by a peeling method from graphite, or by growing it on a metal surface using a chemical vapor deposition method (CVD). A single layer or multiple layers of graphene grown on a metal surface were transferred to a polymer film, and then transferred again to a semiconductor substrate for fabricating a desired field effect transistor (FET). Specifically, a graphene layer was formed on the surface of the copper foil by CVD in which methane gas was flowed at about 1000°C.

Next, a polymethyl methacrylate film was applied at 4000 rpm using a spin coating method, the copper foil film on the opposite surface was etched with a 0.1 M ammonium persulfate solution, and the graphene film floating in the solution was recovered. As a result, the graphene film is transferred to the polymethylmethacrylate film side. After sufficiently cleaning the surface, it was transferred again onto the silicon substrate. Excess polymethyl methacrylate film was dissolved by acetone and removed. The graphene transferred to the silicon substrate was patterned by applying a resist, and a pattern with an electrode interval of 10 μm was formed by oxygen plasma. An FET having a source electrode and a drain electrode was formed by vapor deposition of electrodes. A GFET sensor was fabricated in which graphene was arranged on an oxide film formed on the surface of a silicon substrate, the graphene was sandwiched between a source electrode and a drain electrode, and the silicon substrate side was used as a gate electrode. The order of the steps may be reversed, that is, the electrodes may be formed first, and the graphene may be transferred and processed later.

Next, an organic substance probe was provided on the graphene surface. The organic matter probe was dissolved in a methanol solution at a concentration of 10 nM, and the GFET surface was immersed in this solution for several minutes and set. In Example 1, a probe having an organic compound 100A was installed in the detection cell A shown in FIG. , detection cell D was equipped with a probe containing organic compound 100D, detection cell E was equipped with a probe containing organic compound 100E, and detection cell F was equipped with a probe containing organic compound 100F.

Next, the aforementioned NMPA was prepared as target molecule 2 . For target molecule 2, the vapor was diluted with nitrogen gas to a concentration of about 5 ppb, and this diluted gas was sent to the molecular detection device equipped with the detection element. NMPA molecules were captured by organic probes in detection cells AF, respectively. Since the organic substance probes of the detection cells A to F have different binding strengths with NMPA molecules, the signals detected by the gate electrodes are also different. The results detected by the detection cell were sent to a discriminator for signal processing and converted into intensities. Detection results were output as relative intensity representations. Each intensity is shown in Table 1.

(Example 2)
A GFET sensor was fabricated in the same manner as in Example 1. Furthermore, an organic substance probe was provided on the surface of the graphene. The organic matter probe was dissolved in a methanol solution at a concentration of 10 nM, and the GFET surface was immersed in this solution for several minutes and set. In Example 2, a probe having an organic compound 100A is installed in the detection cell A shown in FIG. A probe combined with a probe containing 100D is placed, a probe combined with a probe containing organic compound 100E and a probe containing organic compound 100F are placed in detection cell D, and a probe containing organic compound 100C is placed in detection cell E. A probe combined with a probe containing the organic compound 100F was placed, and a probe combined with a probe containing the organic compound 100B and a probe containing the organic compound 100D was placed in the detection cell F. The number ratios of the various probes in detection cells C to F are the same.

Next, the aforementioned NMPA was prepared as target molecule 2 . For target molecule 2, the vapor was diluted with nitrogen gas to a concentration of about 5 ppb, and this diluted gas was sent to the molecular detection device equipped with the detection element. NMPA molecules were captured by organic probes in detection cells AF, respectively. Since the organic substance probes of cells A to F have different binding strengths with NMPA molecules, the signals detected by the gate electrodes are also different. The results detected by the detection cell were sent to a discriminator for signal processing and converted into intensities. Detection results were output as relative intensity representations. Each intensity is shown in Table 2.

As can be seen from Tables 1 and 2, in the molecular detection devices of Examples 1 and 2, specific signal patterns can be obtained for NMPA molecules. In addition, it can be seen that in the molecular detection devices of Examples 1 and 2, signal patterns with different intensities can be obtained.

It should be noted that while several embodiments of the invention have been described, these embodiments are provided by way of example and are not intended to limit the scope of the invention. These novel embodiments can be embodied in various other forms, and various omissions, replacements, and modifications can be made without departing from the scope of the invention. These embodiments and modifications thereof are included in the scope and gist of the invention, and are included in the scope of the invention described in the claims and equivalents thereof.

DESCRIPTION OF SYMBOLS 1... Molecular detection apparatus, 2... Target molecule, 3... Target gas, 4... Contaminants, 5... Filter device, 6... Molecular distribution apparatus, 6a... Edge, 10... Detector, 10A... Detection surface, 11... Sensor , 12... Organic probe, 12a... Organic probe, 12b... Organic probe, 13... Detection element, 14... Gate electrode, 15... Gate insulating layer, 16... Graphene layer, 17... Source electrode, 18... Drain electrode, 20... Identification Device, 30... Information processing section, 31... Information transmitting section, 32... Information receiving section, 33... Information collating section, 100A to 100F... Organic compound, 101... Detection cell.

Claims (11)

a first organic substance probe;
a second organic substance probe;
Each of the first and second organic probes is
An organic compound having a head portion having a purine structure, a pyrimidine structure, or a triazine structure, a base portion that bonds to a substrate, and a bonding portion that connects the head portion and the base portion,
The base portion has a monovalent polycyclic aromatic hydrocarbon group,
The first organic probe and the second organic probe are bound,
The organic probe, wherein the second organic probe has a structure different from that of the first organic probe. the first organic probe includes the purine structure;
the second organic probe includes the pyrimidine structure;
2. The organic probe according to claim 1, wherein said purine structure and said pyrimidine structure are bonded by hydrogen bonding. the first organic probe includes the triazine structure;
the second organic probe includes the purine structure or the pyrimidine structure;
2. The organic substance probe according to claim 1, wherein said triazine structure and said purine structure or said pyrimidine structure are bonded by a hydrogen bond. the purine structure includes an adenine structure or a guanine structure,
The adenine structure or the guanine structure has a carbonyl group or an amine group,
The organic substance probe according to any one of claims 1 to 3 . the pyrimidine structure comprises a thymine structure or a cytosine structure,
5. The organic substance probe according to claim 1, wherein said thymine structure or cytosine structure has a carbonyl group and an amine group. The triazine structure includes a cyanuric acid structure,
2. The organic substance probe according to claim 1 , wherein said cyanuric acid structure has a carbonyl group and an amine group. an organic substance probe according to any one of claims 1 to 6 ;
and a detection cell that detects the target molecule through interaction between the organic substance probe and the target molecule. an organic substance probe according to any one of claims 1 to 6 ;
a detection cell that detects the target molecule through interaction between the organic substance probe and the target molecule;
The detection cell detects the target molecule by cleaving a hydrogen bond between the first organic probe and the second organic probe and detecting the target molecule. 9. The molecular detection device according to claim 7 , wherein said target molecule includes an amine derivative compound. 10. The molecular detection device according to claim 8 , wherein the detection cell includes a field effect transistor having a graphene layer containing graphene provided with the organic substance probe and an electrode connected to the graphene layer. 11. The molecule detection device according to any one of claims 8 to 10, further comprising a discriminator that discriminates the target molecule based on the detection signal from the detection cell.

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