JP5926806B2 - アブレーションされた組織を視覚化するシステムと方法 - Google Patents
アブレーションされた組織を視覚化するシステムと方法 Download PDFInfo
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Description
Claims (26)
- 血管組織を撮影するシステムであって、
末端部と基端部を有し、血管組織に血管内から接近できる大きさの血管カテーテルと、
前記血管カテーテルの前記末端部の近くに配置され、紫外線透過材料で形成されて前記血管組織に対して配置される形状を有する膨張可能なバルーンと、
前記血管カテーテルを前記血管組織に案内するガイドワイヤと、
前記血管組織の一部を除去するために前記バルーンの外側に配置されたアブレーション部材と、
前記血管カテーテルから前記バルーンの中に伸びる光学ハウジングとを有し、
前記光学ハウジングは、前記バルーンの外側で前記血管組織を照明して前記血管組織のNADH蛍光を励起するために、約300ナノメートルから約400ナノメートルの間の波長を有する光を出射する紫外線源と、前記照明された組織を撮影するカメラとを有する、システム。 - 前記光源が紫外線の発光ダイオード(LED)である、請求項1のシステム。
- 前記カメラが、光学画像を電子信号に変換する撮像センサを含む、請求項1のシステム。
- 前記光学ハウジングの外面と前記バルーンの内壁との間に隙間が形成されており、
前記隙間は、前記血管カテーテルの膨張ルーメンと前記バルーンとの間に、前記バルーンを収縮するための流体経路を提供する、請求項1のシステム。 - 前記バルーンに対して前記光学ハウジングが回転する、請求項1のシステム。
- 前記バルーンを支持するための支持構造を提供するために、前記カテーテルの前記末端部を越えて伸びる支持チューブを有する、請求項1のシステム。
- 前記支持チューブの末端部近傍に先端を備えており、前記先端はアブレーション部材として機能するように構成されている、請求項6のシステム。
- 前記アブレーション部材を前記バルーンの末端側に向けて移動させるために、前記支持チューブは前記カテーテルの内腔に連通する内側ルーメンを有する、請求項6のシステム。
- 第1の光源と、前記第1の光源とは異なる波長の光を発生することができる第2の光源を有する、請求項1のシステム。
- 前記カメラで検出されたNADH蛍光に基づいて、照明された組織の画像を作成するために、前記カメラに接続されたディスプレイ装置を有する、請求項1のシステム。
- 前記カメラと前記ディスプレイ装置は無線接続されている、請求項10のシステム。
- 前記カメラに連結され、中心波長が460ナノメートルで、50ナノメートルのバンド幅を有するフィルタを有する、請求項1のシステム。
- 前記カメラが、約460ナノメートルの波長に対して少なくとも約50〜約70%の量子効率を有する電荷結合素子(CCD)カメラに連結されている、請求項1のシステム。
- 前記カメラが、約460ナノメートルの波長に対して約90%の量子効率を有する電荷結合素子(CCD)カメラに連結されている、請求項1のシステム。
- 血管組織を撮影するシステムであって、
末端部と基端部を有し、血管組織に血管内から接近できる大きさの血管カテーテルと、
前記血管カテーテルの前記末端部を超えて伸び且つ末端部の周りに先端部を有する支持チューブと、
前記血管カテーテルの前記末端部の周りに配置されており、紫外線透過材料で形成されて前記血管組織の近くに配置される形状を有する膨張可能なバルーンと、
前記血管カテーテルを前記血管組織に案内するガイドワイヤと、
前記血管組織の一部を除去するために前記バルーンの外側に配置されたアブレーション部材と、
前記血管カテーテルから前記バルーンの中に伸びる光学ハウジングと、
前記バルーンの内側に設けた紫外線源であって、前記紫外線源は前記光学ハウジングに支持されており、前記紫外線源は前記バルーンの外側で前記血管組織を照明して前記血管組織のNADHを励起するために、約300ナノメートルから約400ナノメートルの間の波長を有する光を出射する紫外線源と、
前記バルーンの内側に設けたカメラであって、前記光学ハウジングに支持されており、前記紫外線源からの光で照明された前記血管組織からのNADH蛍光を検出して、前記紫外線源の光で照明された組織を撮影するカメラと、を有するシステム。 - 前記光学ハウジングは、前記バルーンに対して前記カメラと前記光源を回転するように、前記バルーンに対して回転可能である、請求項15のシステム。
- 白色光を提供するための第2の光源を備えている、請求項15のシステム。
- 前記カメラに連結され、中心波長が460ナノメートルで、50ナノメートルのバンド幅を有するフィルタを有する、請求項15のシステム。
- 前記カメラが、約460ナノメートルの波長に対して少なくとも約50〜約70%の量子効率を有する電荷結合素子(CCD)カメラに連結されている、請求項15のシステム。
- 前記カメラが、約460ナノメートルの波長に対して約90%の量子効率を有する電荷結合素子(CCD)カメラに連結されている、請求項15のシステム。
- 血管組織を撮影するシステムであって、
末端部と基端部を有し、心臓組織に血管内から接近できる大きさの血管カテーテルと、
前記血管カテーテルを前記心臓組織に案内するガイドワイヤと、
前記血管カテーテルの前記末端部に配置されたアブレーション部材と、
前記カテーテルの前記末端部の周りの血管を流体に置き換えるかん流ポートと、
前記カテーテルの前記末端部から伸びる光学ハウジングであって、前記光学ハウジングは発光ダイオード光源を支持するように構成されており、前記発光ダイオード光源は前記心臓組織を照明して前記心臓組織のNADHを励起するために約300ナノメートルから約400ナノメートルの間の光を出射し、前記光学ハウジングはまた前記照明された組織を撮影するために光学画像を電子信号に変換する複数の撮像センサを含む撮影装置を有する、光学ハウジングと、
前記血管カテーテルの前記末端部の周りに配置された膨張可能なバルーンであって、前記バルーンは紫外線透過材料で形成されており且つ前記心臓組織に対して配置される形状を有する、バルーンとを備えており、
前記発光ダイオード光源と前記撮影装置は、前記血管カテーテルの前記末端部を超えて、前記バルーンの内側に配置されている、システム。 - 組織を撮影するシステムであって、
血液を移動させるとともに光を送ることができる、流体を注入するためのシースと、
前記シース内に配置され、末端部と基端部を有し、心臓組織に血管を通じて接近できる大きさを有する血管カテーテルと、
前記血管カテーテルを前記心臓組織に案内するガイドワイヤと、
前記血管カテーテルの前記末端部に配置されたアブレーション部材と、
前記カテーテルの前記末端部から伸びる光学ハウジングであって、前記光学ハウジングは発光ダイオード光源を支持するように構成されており、前記発光ダイオード光源は前記心臓組織を照明して前記心臓組織のNADHを励起するために約300ナノメートルから約400ナノメートルの間の光を出射し、前記光学ハウジングはまた前記照明された組織を撮影するために光学画像を電子信号に変換する複数の撮像センサを含む撮影装置を有する、光学ハウジングと、
前記血管カテーテルの前記末端部の周りに配置された膨張可能なバルーンであって、前記バルーンは紫外線透過材料で形成されており且つ前記心臓組織に対して配置される形状を有する、バルーンとを備えており、
前記発光ダイオード光源と前記撮影装置は、前記血管カテーテルの前記末端部を超えて、前記バルーンの内側に配置されている、システム。 - 心臓組織を撮影するシステムであって、
末端部と基端部を有し、血管組織に血管内から接近できる大きさの血管カテーテルと、
前記血管カテーテルの前記末端部の近くに配置され、紫外線透過材料で形成されて前記血管組織に対して配置される形状を有する膨張可能なバルーンと、
前記血管カテーテルを前記血管組織に案内するガイドワイヤと、
前記血管カテーテルを介してアブレーションするために、前記バルーンの外側に配置されたアブレーション部材と、
前記血管カテーテルの外側に配置され、約300ナノメートルから約400ナノメートルの間の波長を有する光を提供する光源と、
前記膨張可能なバルーンの内側に末端部を有するとともに前記光源に接続された、1つ又は複数の光伝送ファイバと、
前記血管カテーテルの外側に配置された電荷結合素子(CCD)カメラと、
前記膨張可能なバルーンの内側に末端部を有し且つ前記電荷結合素子(CCD)カメラに接続された、1つ又は複数の撮影用ファイバとを有する、システム。 - 前記カメラに連結され、中心波長が460ナノメートルで、50ナノメートルのバンド幅を有するフィルタを有する、請求項23のシステム。
- 前記カメラが、約460ナノメートルの波長に対して少なくとも約50〜約70%の量子効率を有する電荷結合素子(CCD)カメラに連結されている、請求項23のシステム。
- 前記カメラが、約460ナノメートルの波長に対して約90%の量子効率を有する電荷結合素子(CCD)カメラに連結されている、請求項23のシステム。
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