JP5686454B1 - Contact lens mounting liquid and method for improving refractive index of contact lens using the same - Google Patents

Abstract

[PROBLEMS] To provide a novel contact lens mounting solution that improves the wettability of a contact lens and achieves elimination of poor visibility immediately after mounting and prevention of bacterial adhesion. As the component (A), at least one selected from flavin adenine dinucleotide sodium, cyanocobalamin, retinol acetate, retinol palmitate, pyridoxine hydrochloride, panthenol, calcium pantothenate, sodium pantothenate, tocopherol acetate, When each of two or more kinds is selected at 0.00005 to 0.0025% by weight, it is contained so that the sum of the blending amounts thereof is less than 0.015% by weight. Further, as component (B), polyvinyl alcohol And at least one selected from hypromellose and polyvinylpyrrolidone, and not including any of pranoprofen, tranilast, acitazanolast, anhydrous caffeine, berberine chloride, lomefloxacin hydrochloride, and zinc sulfate. [Selection figure] None

Description

The present invention relates to a contact lens mounting solution used for adhering to a contact lens when the contact lens is mounted, such as a contact lens mounting solution, a mounting drug, and a contact lens preserving solution. The present invention also relates to the refractive index improving how the contact lens using such contact lens mounting solutions.

  Conventionally, contact lenses mounted on the cornea include contact lens storage solutions that have been soaked before mounting, and contact lens mounting solutions that are separately applied to contact lenses before mounting for the purpose of improving wearing comfort. The liquid for mounting is attached, and the smooth insertion of the contact lens onto the cornea is realized by suppressing the foreign object feeling and discomfort that tend to occur when the contact lens is worn.

  As an example of such a contact lens mounting liquid, Japanese Patent Application Laid-Open No. 2001-125052 (Patent Document 1) discloses a contact lens that improves the wearing feeling of the contact lens by improving the wettability of the contact lens. The mounting fluid is described. In the contact lens mounting liquid described in Patent Document 1, the wettability of the contact lens surface is improved by blending polyvinyl alcohol or hypromellose (hydroxypropylmethylcellulose) as a thickener. Discomfort is suppressed.

  By the way, contact lens mounting solutions such as contact lens preservatives and mounting drugs that were attached to the contact lens when the contact lens was mounted mix with tear fluid on the cornea due to blinking or movement of the contact lens. It is known that the so-called Schlieren phenomenon in which distortion such as haze occurs due to the difference in refractive power between the two causes the field of view to become unstable temporarily, resulting in insufficient visual acuity.

  Such temporary poor visibility due to the Schlieren phenomenon is solved by uniformly mixing the tear solution and the contact lens mounting liquid with frequent blinking, but it was particularly attached to the contact lens. When the contact lens mounting liquid is higher in viscosity than tear fluid as described in Patent Document 1, it is difficult to mix them quickly, and it may take time to eliminate poor visibility. It was. Due to such poor visibility, there was a problem that it was very dangerous to drive a car or operate a machine immediately after wearing a contact lens.

  However, effective measures are currently not taken against temporary visual field failures due to the Schlieren phenomenon immediately after wearing, and users rub their eyes or blink more than necessary. So I had to resolve the poor visibility.

  In addition, the occurrence of eye damage due to bacterial adherence to contact lenses (including fashionable contact lenses) is a problem, and is particularly correlated with the wettability of contact lenses. As a matter of course, no means has been proposed for achieving both the improvement of the wettability of the contact lens as well as the problem of poor visibility immediately after wearing and the problem of bacterial adhesion.

JP 2001-125052

  The present invention has been made in the background of the above-mentioned circumstances, and the problem to be solved is to improve the wettability of the contact lens and improve the wearing feeling, while eliminating the poor visibility immediately after wearing and the adhesion of bacteria. An object of the present invention is to provide a novel contact lens mounting solution that can achieve both preventions. It is another object of the present invention to provide a method for improving the refractive index of a contact lens, a method for suppressing bacterial adhesion, and a method for suppressing moisture transpiration using such a contact lens mounting solution.

  In order to solve the above-mentioned problems, the present inventors have intensively studied to eliminate the temporarily unstable visual field due to the schlieren phenomenon immediately after wearing and the poor visual field due to the lack of visual acuity, and clear the visual field immediately after wearing. In order to solve this problem, the contact lens surface is of course uniformly wetted, but it has been newly found that it can be eliminated by temporarily increasing the vertex power of the lens. And even if temporarily increasing the vertex power of the contact lens creates a state where the power of the lens is too strong, that is, overcorrection, the degree of increase in the vertex power should be limited. Thus, the present invention has been completed.

A first aspect of the present invention according to the contact lens mounting solutions, as the component (A), flavin adenine dinucleotide sodium, cyanocobalamin, retinol acetate, pyridoxine hydrochloric acid, panthenol, calcium pantothenate, sodium pantothenate, tocopherol acetate At least one selected from the group consisting of 0.00005 to 0.0025% by weight, such that when two or more are selected, the sum of their blending amounts is less than 0.015% by weight, and And (B) component containing at least one selected from polyvinyl alcohol, hypromellose, and polyvinylpyrrolidone, and pranoprofen, tranilast, acitazanolast, anhydrous caffeine, berberine chloride, lomefloxacin hydrochloride, zinc sulfate , palmiticin Retinol, acid B, phenylethyl alcohol, it does not contain benzyl alcohol, any of ethanol, characterized in that.

  According to this aspect, while containing the said (B) component conventionally used for the liquid agent for contact lens mounting as a thickener etc., at least 1 sort (s) of said (A) component is 0.00005-0. In the case where two or more types are selected at 0025% by weight, the sum of their blending amounts is less than 0.015% by weight, and by containing in a specific range, while ensuring improvement in wearing feeling at the time of wearing, For the first time, it was possible to demonstrate the function of improving the refractive power of a contact lens, which cannot be exhibited by conventional mounting liquids. Vitamins that have been conventionally formulated as active ingredients such as eye drops and the like have surprisingly been found that these ingredients contribute to improving the refractive index of contact lenses. Moreover, by setting the concentration to be lower than the compounding amount showing the effectiveness as vitamins, a desired refractive index improving function could be imparted to the contact lens mounting liquid. Thus, it was found for the first time that the component (A) with a predetermined blending amount contributes to the function of improving the refractive index of the contact lens, and was adopted to solve the problem.

  Specifically, when the contact lens is attached to the contact lens before wearing with the contact lens mounting solution of the present invention, the wettability is improved by the component (B), and the contact lens surface is uniformly wetted. Secured. Furthermore, by containing the component (A) at a specific blending ratio, the vertex refractive power of the contact lens can be improved to the extent that no overcorrection is created. This eliminates the lack of visual acuity caused by the instability of the visual field immediately after wearing the contact lens, and does not create overcorrection because the formulation is optimized. Moreover, by improving the wettability by the component (B), it is possible to simultaneously improve the feeling of wearing at the same time as before. In addition, in the case of only the component (B) conventionally used as a thickener, it induces a lack of visual acuity that has been a problem conventionally, and since the component (A) is not included, the above-mentioned lack of visual acuity is also compensated. Absent.

  In addition, since the composition does not contain any of pranoprofen, tranilast, acitazanolast, anhydrous caffeine, berberine chloride, lomefloxacin hydrochloride, or zinc sulfate, the (A) component and the (B) component are combined. It is advantageously avoided that the refractive index improvement rate of the contact lens, which is a unique effect produced by the inclusion, is excessive.

  Furthermore, the present inventors contain a combination of the component (A) and the component (B), and further include any of pranoprofen, tranilast, acitazanolast, anhydrous caffeine, berberine chloride, lomefloxacin hydrochloride, and zinc sulfate. Therefore, it has also been newly found that, due to the synergistic effect thereof, it has a function of suppressing bacterial adhesion to a remarkable contact lens, which has never been seen before. As a result, the contact lens mounting solution of the present invention has both the improvement of wearing feeling by improving the wettability of the contact lens and the elimination of poor visibility immediately after mounting, as well as the effect of suppressing the adhesion of bacteria to the contact lens. An epoch-making contact lens mounting solution that can be achieved at the same time can be provided.

  A second aspect of the present invention relating to a contact lens mounting solution is the contact lens refraction at 20 ° C. when purified water is attached to the contact lens in the contact lens mounting solution described in the first aspect. The contact lens refractive index is improved by 0.05% or more and 3.3% or less with respect to the ratio.

  According to this aspect, the refractive index improving function has a contact lens refractive index of 0.05% or more and 3.3% or less with respect to the contact lens refractive index at 20 ° C. when purified water is attached to the contact lens. Since the improvement rate is brought about, the lack of visual acuity immediately after wearing the contact lens and the avoidance of overcorrection can be reliably achieved.

  According to a third aspect of the present invention relating to a contact lens mounting liquid, in the contact lens mounting liquid described in the first or second aspect, the contact lens is a contact lens that is not surface-treated. . With respect to a contact lens that is not subjected to such surface treatment, the refractive index improving function of the present invention is more advantageously exhibited. Specifically, the contact lens refractive index can be improved by 0.05% or more and 3.3% or less with respect to the contact lens refractive index when purified water is adhered to the contact lens.

  According to a fourth aspect of the present invention relating to a contact lens mounting liquid, in the contact lens mounting liquid described in any one of the first to third aspects, the contact lens contains boric acid. It is a soft contact lens that has been immersed and stored in a distribution storage solution.

  Generally, in the distribution of soft contact lenses (soft contact lenses such as disposable and non-reusable soft contact lenses, frequent contact type soft contact lenses, and regular replacement type soft contact lenses), physiological saline is used as a preservative solution, It is distributed and sold after high-pressure steam sterilization with soft contact lenses immersed in vials, blister cases, and aluminum pouches. In the distribution stock solution, various pH buffering agents such as boric acid and phosphoric acid are blended for the purpose of storage stability at the expiration date. From the viewpoint of bacterial control during contact lens production, bacteriostatic In many cases, a borate buffer having excellent properties is used. The inventors of the present invention have a specific range (A) component and (B) component in accordance with the present invention for a soft contact lens that has been soaked and stored in a contact lens circulation preservation solution containing boric acid. It has also been newly found that the contact lens mounting solution has an effect of suppressing moisture transpiration.

  According to a fifth aspect of the present invention relating to a contact lens mounting liquid, in the contact lens mounting liquid described in any one of the first to fourth aspects, a care product in which the contact lens contains boric acid. It is a soft contact lens that is mounted after being processed by.

  In recent years, as care products (hereinafter referred to as contact lens care products) for sterilization, disinfection, storage and rinsing of frequent exchange type soft contact lenses, periodic exchange type soft contact lenses, etc., as pH buffering agents, or Care products containing boric acid are generally widely used for the purpose of improving the storage efficacy and the bactericidal effect. The present inventors have prepared a contact lens mounting solution containing the components (A) and (B) within a specific range according to the present invention for soft contact lenses treated with a care product containing boric acid. However, it has also been found that it has an effect of suppressing moisture transpiration.

  According to a sixth aspect of the present invention relating to a contact lens mounting solution, in the contact lens mounting solution described in any one of the first to fifth aspects, the contact lens mounting agent, the contact lens rinsing solution, and the contact lens It is used as at least one selected from circulating stock solutions.

  According to this aspect, it is possible to advantageously provide an excellent contact lens mounting liquid and the like that can achieve both improvement in wearing feeling of a contact lens and improvement in poor visibility immediately after mounting.

  A first aspect of the present invention relating to a method for improving the refractive index of a contact lens is as follows: (A) component flavin adenine dinucleotide sodium, cyanocobalamin, acetic acid retinol, retinol palmitate, pyridoxine hydrochloride, panthenol, calcium pantothenate, pantothene When at least one selected from sodium acid and tocopherol acetate is selected from 0.00005 to 0.0025% by weight, and when two or more are selected, the sum of the blending amounts is less than 0.015% by weight. And at least one selected from polyvinyl alcohol, hypromellose and polyvinylpyrrolidone as component (B), and pranoprofen, tranilast, acitazanolast, anhydrous caffeine, berberine chloride , Lomefloxacin hydrochloride Using a contact lens wetting solutions that do not contain any of zinc sulfate, before wearing contact lenses, the contact lens mounting liquid is brought into contact with the contact lens, it is characterized.

  According to this aspect, the contact lens mounting solution according to the present invention is temporarily brought about by the Schlieren phenomenon immediately after mounting, which has been a problem in the past, by a simple method of simply contacting the contact lens before the mounting of the contact lens. Such poor visibility can be eliminated by temporarily improving the refractive index of the contact lens. In addition, the component (A) is temporarily taken into the surface or inside of the contact lens or stays in the tear film between the cornea and the lens. The component (A) is released from The component (B) also serves to control the amount of the above component (A) incorporated into the contact lens and the release rate. Therefore, in the first aspect of the present invention relating to the method for improving the refractive index of the contact lens, as described above, the release control of the component (A) from the contact lens using the contact lens mounting solution according to the present invention. It also includes methods.

  The first aspect of the present invention relating to the method for inhibiting bacterial adhesion of contact lenses is as component (A): flavin adenine dinucleotide sodium, cyanocobalamin, acetic acid retinol, retinol palmitate, pyridoxine hydrochloride, panthenol, calcium pantothenate, pantothenic acid When at least one selected from sodium acid and tocopherol acetate is selected from 0.00005 to 0.0025% by weight, and when two or more are selected, the sum of the blending amounts is less than 0.015% by weight. And at least one selected from polyvinyl alcohol, hypromellose and polyvinylpyrrolidone as component (B), and pranoprofen, tranilast, acitazanolast, anhydrous caffeine, berberine chloride , Lomefloxaci hydrochloride , Using a contact lens wetting solutions that do not contain any of zinc sulfate, before wearing contact lenses, the contact lens mounting liquid, said contacting in the contact lenses, it is characterized in.

  According to this aspect, the contact lens mounting solution according to the present invention has an effect of suppressing bacterial adhesion to the contact lens, which is not conventionally obtained, by a simple method of simply contacting the contact lens before mounting the contact lens. It is obtained.

  The first aspect of the present invention relating to the method for suppressing moisture evaporation of contact lenses is that flavin adenine dinucleotide sodium, cyanocobalamin, retinol acetate, retinol palmitate, pyridoxine hydrochloride, panthenol, calcium pantothenate, pantothene as component (A) When at least one selected from sodium acid and tocopherol acetate is selected from 0.00005 to 0.0025% by weight, and when two or more are selected, the sum of the blending amounts is less than 0.015% by weight. And at least one selected from polyvinyl alcohol, hypromellose and polyvinylpyrrolidone as component (B), and pranoprofen, tranilast, acitazanolast, anhydrous caffeine, berberine chloride , Lomefloxaci hydrochloride , Using a contact lens mounting solution that does not contain any of zinc sulfate, and before the contact lens is mounted, the contact lens mounting solution, boric acid pre-adhered to the contact lens, contact lens circulation storage solution, It is made to contact on the said contact lens with at least 1 type chosen from a contact lens care article.

  According to this aspect, the contact lens mounting solution according to the present invention is brought into contact with the contact lens before the contact lens is mounted, and the contact lens distribution storage solution containing boric acid previously attached to the contact lens, contact lens care An effect of suppressing moisture evaporation of a contact lens, which cannot be obtained conventionally, can be obtained by a simple method in which at least one selected from articles is brought into contact with the contact lens. For contact lens care products, soft contact lenses can be sterilized, cleaned, rinsed and stored in a single solution, a multipurpose solution for soft contact lenses (so-called multi-purpose solution (MPS)), and hydrogen peroxide preparations. Sterilization, cleaning, neutralization, rinsing, contact lens sterilization, povidone iodine preparation, povidone iodine formulation, neutralizing agent (neutralizing tablet), and contact lens sterilization, cleaning In addition, a contact lens rinsing solution for removing residual unneutralized hydrogen peroxide and povidone iodine after storage is included.

  According to the contact lens mounting liquid according to the present invention, the component (B) and the component (A), which are conventionally used in liquids for mounting a contact lens as a thickener or the like, are contained at a specific blending ratio, Furthermore, by not containing any of pranoprofen, tranilast, acitazanolast, anhydrous caffeine, berberine chloride, lomefloxacin hydrochloride, or zinc sulfate, it is the first time to improve the wettability of contact lenses and the poor visibility immediately after wearing. In addition, it was possible to simultaneously achieve any effect of suppressing the adhesion of bacteria to contact lenses. Further, by simply bringing the contact lens mounting solution of the present invention into contact with the contact lens before mounting, it is possible to temporarily improve the refractive power of the contact lens immediately after mounting or to suppress bacterial adhesion to the contact lens. Furthermore, the contact lens mounting solution of the present invention is attached to the contact lens before mounting, and contact with at least one selected from a contact lens distribution storage solution containing boric acid previously attached to the contact lens, contact lens care products The water evaporation of the contact lens can be suppressed only by making contact on the lens.

  Hereinafter, in order to clarify the present invention more specifically, an embodiment of the present invention relating to a contact lens mounting solution will be described in detail.

  The contact lens mounting solution as one embodiment of the present invention comprises, as component (A), flavin adenine dinucleotide sodium, cyanocobalamin, acetate retinol, retinol palmitate, pyridoxine hydrochloride, panthenol, calcium pantothenate, sodium pantothenate, At least one selected from tocopherol acetate is contained at 0.00005 to 0.0025% by weight, so that when two or more are selected, the sum of the blending amounts is less than 0.015% by weight. And as a (B) component, at least 1 sort (s) selected from polyvinyl alcohol, a hypromellose, and polyvinylpyrrolidone is contained. And the refractive index improvement function and bacterial adhesion suppression function of a contact lens can be exhibited by mix | blending combining the (A) component and (B) component of this specific range.

  More specifically, the contact lens mounting liquid according to the present embodiment can be used as various solutions that are attached to the contact lens and used when the contact lens is mounted. For example, the contact lens mounting solution described in “Pharmaceutical Manufacturing Guidelines, separate volume, OTC Manufacturing (Import) Approval Standard 2000 Edition; Pharmaceutical Affairs Research Group, Jiho Co., Ltd., June 30, 2000”, “July 2004 Contact Lens Wearing Agent described in and prescribed in the Ministry of Health, Labor and Welfare Ministry of Health, Labor and Welfare Ministry of Food and Drug Administration No. 0716006, “Safety Voluntary Standards for Contact Lens Cleaning Agents, Preservatives, Cleaning Preservatives, 6th revised edition” It is preferably used as a contact lens preserving solution, a contact lens rinsing solution, or a contact lens distribution preserving solution defined in (General Contact Association, Contact Lens Association, November 2011). It can also be used as a contact lens wearing / eye drop solution that can be instilled, a contact lens wearing / eye wash solution that combines an eye wash and a mounting solution, and a liquid solution that combines a mounting solution and a preservative or distribution preservative solution. Is possible. Generally speaking, it refers to a liquid used in a method of use in which a lens (including care products already in contact with the lens, including a preservative solution) is attached and the lens is mounted as it is before wearing the contact lens. On the other hand, as the application of the contact lens mounting liquid according to the present embodiment, a form that can be used for both a soft contact lens and a hard contact lens is possible, or a form dedicated to a hard contact lens may be used. In the present application, “contact lens mounting drug” and “contact lens mounting liquid” are collectively referred to as “contact lens mounting liquid” without being distinguished from each other. In addition, those used as eyewashes or eye drops alone are excluded from the contact lens mounting solution of the present application.

  The contact lens mounting solution according to the present embodiment can be used for various known contact lenses. For example, hard contact lenses and soft (hydrogel) that meet the contact lens approval criteria described in “Revision of contact lens approval criteria” issued on April 28, 2009 by the Ministry of Health, Labor and Welfare. Includes contact lenses and non-vision correction soft (hydrogel) contact lenses. The non-sight correction software (hydrogel) contact lens includes “changing the appearance (color, pattern, shape) of the iris or pupil” in the efficacy and effect of the contact lens. According to the approval criteria, eyesight correction is not included in the efficacy / effect, but there are actually products that also include eyesight correction in the efficacy / effect. Therefore, in the description of the present application, a contact lens that includes “changing the appearance (color, pattern, shape) of the iris or pupil” in the efficacy / effect, regardless of whether the vision correction is included in the efficacy / effect, is “fashionable” Contact lens ". Fashionable contact lenses include those by the so-called sandwich method in which the dye interface is covered with a contact lens material and those in which the dye is exposed to the contact lens surface. Furthermore, those of hydrogel materials classified as groups I to V in ISO 18369-1 (2006 and Amendment 1, 2009) and non-hydrogel materials classified as groups I to IV (non-hydrogel) materials). In addition, eye contact, anterior chamber sealing, drug delivery, corneal curvature changes (including orthokeratology contact lenses), retina treatment, and other therapeutic and examination contact lenses, visual field contrast It also includes sunglasses contact lenses that have functions such as amplification and reduction of incident light, reduction of incident light, polarization, and dimming. In the present application, when the term “hard contact lens” is simply used, it means a hard lens corresponding to the above notification, standard, or the like. Even in the case of simply indicating “soft contact lens”, it means a soft lens corresponding to the above notification, standard, or the like.

  Concerning the shape of contact lenses, there are two or more types of materials, including corneal contact lenses, semi-scleral contact lenses, scleral contact lenses, and hybrid contact lenses (contact lenses that combine oxygen-permeable hard contact lenses and soft contact lenses). It may be a contact lens). Any contact lens design may be used, such as for astigmatism, for farsightedness, for astigmatism, for both near and near, and for shortsightedness. The contact lens may be a disposable contact lens that is used only for a short period such as one day or one week to several months, or may be a normal contact lens that is used for a longer period of time. Good. In order to impart wettability to the contact lens, surface treatment (physical treatment such as plasma treatment or chemical treatment such as graft polymerization) may be performed as secondary processing in the manufacturing process of the contact lens. The contact lens mounting liquid according to the present embodiment can be used for all known contact lenses regardless of the presence or absence of the surface treatment of the contact lens. This can be advantageously achieved in soft contact lenses that have not been subjected to. On the other hand, with regard to hard contact lenses, among non-hydrogel materials classified as groups I to IV in the above-mentioned ISO 18369-1 (2006), particularly silicon components and fluorine components are included in contact lens materials. Those belonging to Group III included in can be advantageously exhibited.

  The component (A) blended in this contact lens mounting solution is selected from flavin adenine dinucleotide sodium, cyanocobalamin, retinol acetate, retinol palmitate, pyridoxine hydrochloride, panthenol, calcium pantothenate, sodium pantothenate, tocopherol acetate At least one kind. The blending ratio of the component (A) is adjusted so that each component is in the range of 0.00005 to 0.0025% by weight, and when two or more kinds are selected, the sum of the blending amounts is less than 0.015% by weight. Have been adjusted so that. Thereby, the vertex refractive power of a contact lens can be suitably improved to such an extent that an overcorrected state is not created for a contact lens wearing eye immediately after wearing. That is, when each component of the component (A) is less than 0.00005% by weight, a sufficient function of improving the refractive index of the contact lens cannot be exhibited. On the other hand, when the blending amount of each of the components (A) exceeds 0.0025% by weight, the desired effect is rather attenuated, which is not preferable. Moreover, even if the component (A) is a single type, if it is added in a large amount, the refractive index may be improved more than necessary, resulting in an overcorrected state. Furthermore, when two or more types of component (A) are selected, the refractive index is improved more than necessary because the sum of the blended amounts is less than 0.015% by weight. Thus, overcorrection is prevented in advance.

  In addition, the blending ratio of the component (A) is 0.00005 to 0.0025% by weight for each component, and when two or more kinds are selected, the sum of the blended amounts is less than 0.015% by weight. The detailed reason why such a refractive index improvement effect is manifested is not clear, but when the contact lens mounting solution comes into contact with the contact lens, the component (A) contributes to the improvement of the refractive index, and the contact lens surface Is taken into the interior, and it is assumed that the refractive index of the contact lens is improved. Here, the refractive index improvement function of the contact lens mounting liquid is when the contact lens mounting liquid of the present embodiment is attached to the contact lens with respect to the refractive index when purified water is attached to the contact lens. Is preferably adjusted so as to bring about an improvement in refractive index of 0.05% or more and 3.3% or less. Further, a more preferable function of improving the refractive index of the contact lens mounting solution is to attach the contact lens mounting solution of the present embodiment to the contact lens with respect to the refractive index when a physiological saline solution is attached to the contact lens. The refractive index is adjusted so as to provide a refractive index improvement rate of 0.2% or more and less than 2.5% under the measurement condition of 20 ° C. As a result, it is possible to reliably achieve the elimination of insufficient visual acuity immediately after wearing the contact lens and the avoidance of overcorrection. In particular, the function of improving the refractive index by the contact lens mounting solution of the present embodiment is remarkably exhibited in a contact lens that has not been surface-treated. (A) Ingredients in the application for approval of manufacture and sale of ingredients may be active ingredients or approved as additives specified in paragraph (6) of the sixteenth revised Japanese Pharmacopoeia General Rules for Preparations [1] General Rules for Preparations However, if it is particularly preferred in this embodiment, the resulting concentration is relatively lower than those previously used and disclosed.

  In addition, the component (A) is temporarily taken into the surface or inside of the contact lens or is retained in the tear film between the cornea and the lens. The component (A) is released from the contact lens. Therefore, immediately after wearing as described above, the refractive index is improved by the component (A), and the lack of visual acuity is resolved. The lack of visual acuity naturally resolves with time and the number of blinks. At that time, since the component (A) is released from the contact lens, the refractive index does not remain improved, but the desired lens power. Therefore, the high frequency state does not continue.

  In addition, the component (B) blended in the contact lens mounting liquid of this embodiment is at least one selected from polyvinyl alcohol, hypromellose, and polyvinylpyrrolidone. The blending ratio of the component (B) is arbitrarily set depending on the specific use of the contact lens mounting solution, but is 0.01 to 3.0 weight, particularly when used as a contact lens mounting solution. It is preferable to blend in the range of about%. Thereby, the contact lens mounting solution can improve the wettability of the contact lens and improve the wearing feeling of the contact lens.

  In addition, as a polyvinyl alcohol, the thing for commercially available industrial use and a pharmaceutical use may be used suitably, However, As a specific characteristic, the viscosity of 2-50 mPa * s of 4 w / w% aqueous solution in 20 degreeC is a thing. Is used. In addition, the saponification degree of polyvinyl alcohol can be variously selected. For example, the saponification type is selected from complete saponification type, intermediate saponification type, and partial saponification type. Among them, the partial saponification type and intermediate saponification type are particularly preferably selected. Furthermore, polyvinyl alcohol (partially saponified product) listed in the Pharmaceutical Additives Standard 2013 is preferable. Specific examples of commercially available products include Gohsenol (registered trademark) EG series manufactured by Nippon Synthetic Chemical Co., Ltd. EG-05, EG-05P, EG-30, EG-30P, EG-40, EG-40P, and VP series made by Nihon Ventures-Poval Co., Ltd. are listed, and the model numbers are VP-03, VP-04 VP-05, VP-10, VP-15, VP-18, VP-20, VP-24, VP-33, VP-45, etc. can be employed. Moreover, as hypromellose (hydroxypropyl methylcellulose), the viscosity of a 2 w / w% aqueous solution at 20 ° C. is 2.5 mPa · s or more, preferably 2.5 to 10,000, more preferably 2.5 to 5000 mPa · s. Used. The viscosity of this hypromellose is a value measured according to the method for measuring the viscosity of hypromellose described in the 16th revision Japanese Pharmacopoeia. Further, such hypromellose is hypromellose listed in the 16th revised Japanese Pharmacopoeia and can be easily obtained on the market, and various substitution degrees of hypromellose can be selected. For example, the substitution degree type is selected from 2208, 2906, and 2910. Among them, those having the substitution degree type of 2910 and 2906 are particularly preferably selected. Specifically, for example, TC-5 (registered trademark) E and TC-5M, TC-5R, TC-5S, METOLOSE (registered trademark) 60SH-50, METOLOSE 60SH-4000, METOLOSE 60SH manufactured by Shin-Etsu Chemical Co., Ltd. -10000, METOLOSE 65SH-50, METOLOSE 65SH-400, METOLOSE 65SH-4000, etc. can be employed. More preferably, those having a substitution degree type of 2910 are selected, and specifically, TC-5E and METOLOSE 60SH-4000 are particularly preferably selected. The polyvinyl pyrrolidone may be any commercially available one as long as it is commercially available, but those listed in the 16th revision Japanese Pharmacopoeia are particularly preferred. Specific examples include Kollidon (registered trademark) (12PF, 17PF, 25, 30, 90F) manufactured by BASF Japan. These can be used individually by 1 type or in combination of 2 or more types.

  Further, the contact lens mounting liquid of the present embodiment is a combination of the component (A) and the component (B) adjusted to the specific mixing amount as described above, so that the conventional contact lens mounting liquid can be used. It can also exert a high bacterial adhesion inhibitory effect that cannot be obtained. That is, even if the component (A) is contained in a predetermined amount, if the component (B) is not included, a sufficient bacterial adhesion inhibitory effect is not exhibited. Even if the component (B) is included, the component (A) in a predetermined amount must be included. Similarly, the effect of inhibiting bacterial adhesion is not exhibited. Furthermore, when (A) component is contained exceeding a predetermined compounding quantity, even if it contains (B) component, a microbe adhesion inhibitory effect is restrict | limited. Although the detailed reason why such a bacterial adhesion inhibitory effect is manifested is not clear, it works as a balanced interaction on the contact lens surface at a specific blending ratio of the component (A) and the component (B). It is estimated that the effect of covering the contact lens surface is exhibited. And, such a bacterial adhesion suppression effect is obtained when the contact lens mounting solution of this embodiment is applied to a contact lens that has not been surface-treated, more preferably a silicone hydrogel contact lens that has not been subjected to a surface treatment. It is advantageous in that.

  In addition, by combining the component (A) adjusted to the specific blending amount as described above and the component (B), the contact lens mounting liquid according to the present embodiment is distributed as a contact lens containing boric acid. Excellent moisture transpiration control when used for soft contact lenses that have been soaked in a preservative solution or treated with contact lens care products containing boric acid and then applied to the eye. The effect can also be exhibited. That is, even if the component (A) is contained in a predetermined amount, if the component (B) is not included, a sufficient moisture transpiration suppressing effect is not exhibited regardless of the presence or absence of boric acid. If the component (A) is not included, a sufficient moisture transpiration suppressing effect is not exhibited regardless of the presence or absence of boric acid. Furthermore, when (A) component is contained exceeding a predetermined compounding amount, even if it contains (B) component, the moisture transpiration suppression effect deteriorates regardless of the presence or absence of boric acid. In short, when the contact lens mounting solution of this embodiment is used for a specific object called a contact lens in contact with a contact lens treatment agent containing boric acid, a remarkable water transpiration suppression effect that has not been seen in the past is exhibited. It is done. Although the detailed reason why such a moisture transpiration suppressing effect is manifested is not clear, the contact lens mounting solution of this embodiment with boric acid blended in the distribution preservation solution and care products attached to the contact lens By mixing, the moisture transpiration rate is delayed due to the interaction between boric acid and the component (B), and the predetermined blending amount of the component (A) becomes a structure due to the interaction between the boric acid and the component (B). It is presumed that the delay of moisture transpiration rate is stably maintained.

  In addition, the remaining amount other than the components (A) and (B) of the predetermined blending amount has a wettability improving effect, a refractive index improving effect, a bacterial adhesion suppressing effect, and further a moisture transpiration suppressing effect of the contact lens mounting solution. As long as it is not impaired, the additive etc. which are used for the composition for a well-known contact lens may be mix | blended in the range accept | permitted ophthalmically. Specifically, for example, known buffers, pH adjusters, surfactants, thickeners, tonicity agents, chelating agents, wetting agents, stabilizers, fragrances or cooling agents, drugs, antibacterial agents, preservatives -A disinfectant etc. may be mix | blended 1 type or in combination of 2 or more types. On the other hand, even if it is a component and density | concentration of the range accept | permitted ophthalmically, the various effects of the liquid used for a contact lens or contact lens wear may be impaired. In addition, there are components that are not suitable for use in liquids used for wearing contact lenses. For example, components such as pranoprofen, acitazanolast, caffeine, tranilast, berberine chloride, lomefloxacin hydrochloride, and zinc sulfate are feared to be adsorbed on the contact lens material and concentrated inside the material. Should be excluded.

  Examples of the buffer include boric acid, borax and borate buffer, carbonate buffer, citric acid and citrate buffer, carboxylic acids such as acetic acid, acids such as oxycarboxylic acid and salts thereof, aminoethyl Amino acids such as sulfonic acid, aspartic acid (salt), glycine, arginine, glutamic acid, ε-aminocaproic acid, 2-amino-2-methyl-1,3-propane (AMP), 2-amino-2-methyl-1 , 3-propanediol (AMPD), tris (hydroxymethyl) aminomethane (Tris), bis (2-hydroxyethyl) iminotris (hydroxymethyl) methane (Bis-Tris), phosphate and phosphate buffer, Good- Buffer etc. are mentioned.

  Examples of the pH adjusting agent include hydrochloric acid, citric acid, acetic acid, sodium hydroxide, potassium hydroxide, sodium carbonate, sodium hydrogen carbonate, sodium hydrogen phosphate, sodium dihydrogen phosphate, phosphates, sulfuric acid and the like. .

  As the surfactant, any of conventionally known anionic surfactants, nonionic surfactants, cationic surfactants, and amphoteric surfactants can be appropriately employed. Examples of such surfactants include polyglycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters (polysorbates), polyoxyethylene alkylphenyl ether formaldehyde condensates, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkylphenyl ether, Polyoxyethylene glycerin fatty acid ester, polyoxyethylene castor oil, polyoxyethylene sterol, polyoxyethylene hydrogenated sterol, polyoxyethylene fatty acid ester, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene block copolymer (poloxamer) ), Polyoxyethylene polyoxypropylene substituted ethylenediamine (poloxamines), polyoxy Tylene lanolin alcohol, polyoxyethylene alkylamine, polyoxyethylene alkylamide, polyoxyethylene alkyl ether phosphate, polyoxyethylene alkyl ether carboxylate, polyoxyethylene alkyl ether sulfate, alkyl fatty acid salt, alkyl phosphate, N-acyl taurine salt, alkyl glutamate, alkyl glycine salt, alkyl alanine salt, cocoyl fatty acid arginine, alkyl sulfate, alkyl sulfonate, betaine acetate type double-sided activator, alkyloxyhydroxypropyl arginine salt, cocoyl arginine ethyl PCA, etc. Is mentioned.

  As the thickener, in addition to the component (B), for example, synthesis of polyethylene glycol, polypropylene glycol, polyacrylamide, poly (meth) acrylic acid and salts, Polymer 845 (copolymer of polyvinyl pyrrolidone and dimethylaminoethyl methacrylate), etc. Organic polymer compounds, etc., cellulose derivatives such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, starch derivatives, alginic acid (salt), pectin, chitosan and their salts, cationization Chitosan derivative polysaccharides such as chitosan, heteropolysaccharides such as gellan gum, hyaluronic acid (salt), chondroitin sulfate (salt), etc. Co polysaccharides may be added.

  Examples of tonicity agents include inorganic salts such as sodium chloride, potassium chloride, sodium bisulfite, sodium sulfite, magnesium chloride, potassium acetate, sodium acetate, sodium thiosulfate, and magnesium sulfate, and polyhydric alcohols such as propylene glycol and glycerin. Alternatively, ethers or esters thereof may be mentioned.

  Examples of chelating agents include ethylenediaminetetraacetic acid (EDTA) and salts thereof (ethylenediaminetetraacetic acid, disodium (EDTA, 2Na), ethylenediaminetetraacetic acid, trisodium (EDTA, 3Na), ethylenediaminetetraacetic acid, tetrasodium (EDTA, 4Na). Etc.), phytic acid, citric acid and the like.

  Examples of the wetting agent include glycerin, propylene glycol, polyethylene glycol, polypropylene glycol, xylitol, sorbitol, mannitol, erythritol, trehalose, glucose, sucrose, maltose, lactose and other polyhydric alcohols, sugars, sugar alcohols, glucosamines (salts), Amino sugars such as acetylglucosamine, galactosamine, acetylgalactosamine, sugar derivatives such as glucosyl trehalose, polyvinylpyrrolidone, poly (meth) acrylic acid and salts, copolymer 845 (copolymer of polyvinylpyrrolidone and dimethylaminoethyl methacrylate), 2-methacryloyloxy Polyvinyl compounds such as ethyl phosphorylcholine, cationized cellulose, hydroxyethyl cellulose Cellulose derivatives such as methylcellulose, lower or higher alcohols such as ethanol, isopropanol, oleyl alcohol, lauryl alcohol, almond oil, lanolin, olive oil, oleic acid and / or salts thereof, liquid paraffin, triglycerides, squalane, petrolatum, silicone oil And oils such as sesame oil, perilla oil, soybean oil, camellia oil, jojoba oil, corn oil and castor oil. In addition, because it is safe for the eyes and reduces the influence on the contact lens, and further improves the usability of the contact lens composition, glycerin, propylene glycol, polyethylene glycol, polypropylene glycol, xylitol, Polysaccharides such as sorbitol, mannitol, erythritol, trehalose, glucose, sucrose, maltose, lactose, sugar derivatives such as sugar, sugar alcohol, glucosyl trehalose, polyvinylpyrrolidone, poly (meth) acrylic acid and salts, Copolymer 845 (polyvinylpyrrolidone and Copolymers of dimethylaminoethyl methacrylate), polyvinyl compounds such as 2-methacryloyloxyethyl phosphorylcholine, and the like, cationized cellulose Scan, it is preferable that the cellulose derivatives such as hydroxyethyl cellulose and methylcellulose are selected.

  Stabilizers include ascorbic acid, ascorbic acid glucoside, sodium edetate, cyclodextrin, condensed phosphoric acid, sulfite, citric acid, dibutylhydroxytoluene, trometamol, sodium formaldehyde sulfoxylate (Longalite), tocopherol, sodium pyrosulfite, Examples include monoethanolamine and aluminum monostearate.

  Examples of the fragrance or refreshing agent include anethole, eugenol, camphor, chlorobutanol, geraniol, cineol, borneol, menthol, limonene, ryuuno, fennel oil, cool mint oil, cinnamon oil, spearmint oil, peppermint water, peppermint oil, peppermint Oil, bergamot oil, eucalyptus oil, rose oil and the like.

  Examples of the drug include antiallergic agents such as cromoglycic acid, chlorpheniramine maleate, diphenhydramine hydrochloride, amlexanox, ibudilast, pemirolast potassium, emedastine fumarate, ketotifen fumarate, olopatadine hydrochloride, ebastine, levocabastine, cetirizine hydrochloride, Glycyrrhizic acid and its salts, ε-aminocaproic acid, allantoin, sodium azulene sulfonate, lysozyme, fluorometholone and other steroidal or nonsteroidal anti-inflammatory agents, epinephrine, epinephrine hydrochloride, ephedrine hydrochloride, naphazoline hydrochloride, naphazoline nitrate, phenylephrine hydrochloride , Vasoconstrictors such as tetrahydrozoline hydrochloride, focus control function improvers such as neostigmine methylsulfate, betaxolol, timolol, di Bephrin, carteolol, latanoplast, tafluplast, travoplast, nipradilol, levobnol and other intraocular pressure-lowering agents, rebamipide, diquafosol sodium and other mucin secretion production promoters, aspartic acid and its salts, aminoethylsulfonic acid, chondroitin sulfate And amino acids such as arginine, alanine, lysine and glutamic acid.

  Antibacterial agents include, for example, sulfamethoxazole, sulfamethoxazole sodium, sulfisoxazole, sulfisomidine sodium and other sulfa drugs, ofloxacin, norfloxacin, levofloxacin, gatifloxacin, moxifloxacin, tosufloxacin , New quinolone antibacterial agents such as ciprofloxacin, aminoglycoside antibacterial agents such as tobramycin, gentamicin, micronomycin, dibekacin and sisomycin, tetracycline antibacterial agents such as tetracycline and minocycline, macrolide antibacterial agents such as erythromycin, Examples include chloramphenicol antibacterial agents such as ramphenicol and cephem antibacterial agents such as cefmenoxime.

  Examples of preservatives and bactericides include sorbic acid, potassium sorbate, benzoic acid or salts thereof, ethyl paraoxybenzoate, butyl paraoxybenzoate, propyl paraoxybenzoate, methyl paraoxybenzoate, chlorobutanol, benzalkonium chloride, Polyhexanide hydrochloride (polyhexamethylene biguanide; PHMB), alkyldiaminoethylglycine hydrochloride, cetylpyridinium chloride (CPC), chlorhexidine, alexidine, chlorpheniramine or a salt thereof, allantoin, chlorine dioxide, stabilized chlorine dioxide, sodium chlorite, And polyquaterniums such as sodium perborate and polydronium chloride. The amount of preservatives and bactericides should be taken into account because of concerns about contact lens adsorption and drug product safety (toxicity). The preferred blending amount is 0.1 ppm to 0.5%, but especially polyhexanide hydrochloride is 5 ppm or less, more preferably 1 ppm or less, and most preferably less than 1 ppm. About polydronium chloride, it is 20 ppm or less, More preferably, it is 15 ppm or less, Most preferably, it is less than 12 ppm. In addition, when such a preservative is used, it is possible to set the expiration date of the product after opening the product to 2 to 3 months, for example. However, the contact lens mounting liquid according to the present embodiment has a preservative. It is also possible not to add so-called preservative-free. In the case of preservative-free, in addition to the normal multi-dose type, it can be a single-dose type that can be used once, or a multi-dose type that can be used several times, or the propagation of bacteria, etc. in the composition does not occur. Thus, an aspect such as a multi-dose type using a filter-equipped discharge container having a structure capable of maintaining sterility can be appropriately selected. It is preferable that the container conforms to the standard and test method of the eye drop plastic container (Notification of Drug Development No. 336) dated March 28, 1996, and the material is polyethylene, polypropylene, polyethylene terephthalate, Polycarbonate, polystyrene, acrylonitrile-styrene copolymer and the like are selected. Examples of the method for forming the container include injection molding, direct blow molding, biaxial stretch blow molding, tube molding, thermoforming molding, and blow fill seal. The container body (bottle) is more preferably selected from direct blow molding, biaxial stretch blow molding, and blow fill seal, which are excellent in moldability, molding accuracy, and confidentiality.

The pH and osmotic pressure of the contact lens mounting solution have an effect on the target wettability improvement effect, refractive index improvement effect, bacteria adhesion suppression effect, moisture evaporation suppression effect, physical properties of the user's eyes and contact lenses, etc. It is desirable to adjust appropriately to a range that does not reach. For example, the pH is desirably adjusted to a range of 3.0 to 9.0, preferably 5.0 to 9.0, and more preferably 5.5 to 8.0. The osmotic pressure is preferably 100 to 1000 mOsm / kg, preferably 170 to 450 mOsm / kg, more preferably 250 to 450 mOsm / kg. In addition, water is desirable as a solvent for hypromellose and polyvinyl alcohol and other additives. Specifically, for example, normal water, purified water, sterilized purified water, and water for injection prescribed by the Japanese Pharmacopoeia, Pure water, distilled water, filtered water or the like is arbitrarily employed. Moreover, the liquid agent for mounting a contact lens in the present embodiment has a kinematic viscosity at 20 ° C. of the liquid of 1.0 to 15.0 mm ² / s. The kinematic viscosity at 20 ° C. of the liquid is more preferably 1.1 to 10.0 mm ² / s, and still more preferably 1.2 to 8.0 mm ² / s. These kinematic viscosities are values measured in accordance with General Test Method 2.53 Viscosity Measurement Method Method 1 described in the 16th revised Japanese Pharmacopoeia.

Although the following Table 1-Table 7 show the specific prescription example of the liquid medicine for contact lens mounting of this embodiment, this invention is not limited by these prescription examples. In addition, when there is no description as a prescription example, it is a contact lens mounting | wearing medicine which can be used for both a hard contact lens and a soft contact lens. In addition, in the table, “instillation / mounting solution” can be used as both an ophthalmic solution and a contact lens mounting solution, “CL” means a contact lens, and “HCL” means a hard contact lens. In addition, the blending amount unit of each component is g / 100 mL unless otherwise stated.
In the table, polyvinyl alcohol (partially saponified product) is Gohsenol EG-05 (manufactured by Nippon Synthetic Chemical Co., Ltd.) or VP-18 (manufactured by Nippon Vinegarten Poval Co., Ltd.). Hypromellose is TC-5E or METOLOSE 60SH-50 or 65SH-50 or 60SH-4000 (above, manufactured by Shin-Etsu Chemical Co., Ltd.). Polyvinylpyrrolidone is Kollidon 25 or Kollidon 90F (manufactured by BASF). Sodium hyaluronate is hyaluronic sun HA-AM or hyaluronic sun HA-QSE (manufactured by QP Corporation). Chondroitin sulfate sodium is an external standard chondroitin sulfate sodium (manufactured by Nippon Biocon Co., Ltd.). The cyclodextrin is Celdex (registered trademark) A-100 (α cyclodextrin: manufactured by Nippon Food Processing Co., Ltd.) or Celdex B-100 (β cyclodextrin: manufactured by Nippon Food Processing Co., Ltd.), and is appropriately selected. Used.

  As described above, according to the contact lens mounting liquid according to the present embodiment, as component (A), flavin adenine dinucleotide sodium, cyanocobalamin, retinol acetate, retinol palmitate, pyridoxine hydrochloride, panthenol, calcium pantothenate, pantothenate, When at least one selected from sodium acid and tocopherol acetate is selected from 0.00005 to 0.0025% by weight, and when two or more are selected, the sum of the blending amounts is less than 0.015% by weight. And at least one selected from polyvinyl alcohol, hypromellose and polyvinylpyrrolidone as component (B), and further, pranoprofen, tranilast, acitazanolast, anhydrous caffeine, berberine chloride, hydrochloric acid Lomefloxasi , It does not contain any of zinc sulfate. As a result, it has become possible to simultaneously achieve both the improvement of wettability of contact lenses, which has been difficult to achieve at the same time, the improvement of poor visibility immediately after wearing, and the effect of suppressing the adhesion of bacteria to contact lenses. It is.

  As mentioned above, although this invention regarding the liquid agent for contact lens mounting has been explained in full detail, demonstrating a suitable embodiment concretely, these are illustrations to the last, Comprising: By this specific description, this invention is what It should not be construed as limiting. For example, the contact lens mounting solution according to the present embodiment has a refractive index improving function and a bacteria adhesion suppressing function, and the present invention includes those that exhibit a further function with respect to a specific contact lens. Of course. Furthermore, a method for imparting a refractive index improving function to a contact lens mounting solution, a method for inhibiting bacterial adhesion, and a function for inhibiting moisture transpiration from the contact lens are also included.

  Hereinafter, in order to further clarify the technical significance of the present invention, the present invention will be described more specifically with reference to examples and comparative examples. However, the present invention is not limited to the following examples.

[Examples 1 to 97, Comparative Examples 1 to 21]
According to the composition table of the following Tables 8 to 26, each component in the table was dissolved in purified water according to a conventional method, pH was adjusted, and then each solution was sterile filtered to prepare a contact lens mounting solution. The following tests were carried out for each of the solutions of Examples 1 to 97 and Comparative Examples 1 to 21 and physiological saline (Japanese Pharmacopoeia physiological saline Otsuka raw food injection Co., Ltd., Otsuka Pharmaceutical Factory). In the following description,% by weight (W / V%) is the same as g / 100 mL. In addition, each component of flavin adenine dinucleotide sodium, cyanocobalamin, retinol acetate, retinol palmitate, pyridoxine hydrochloride, panthenol, calcium pantothenate, sodium pantothenate, and tocopherol acetate shown in Tables 8 to 26 is the component (A). Yes, each component of polyvinyl alcohol, hypromellose and polyvinylpyrrolidone is the component (B). In the table, polyvinyl alcohol (partially saponified product) is VP-18 (manufactured by Nippon Vinegar Poval Co., Ltd.). Hypromellose is METOLOSE 60SH-50 (manufactured by Shin-Etsu Chemical Co., Ltd.). As the polyvinyl pyrrolidone, Kollidon 25 (manufactured by BASF) was used.

[Refractive index improvement function test]
The test contact lens is a typical example of a soft contact lens not subjected to surface treatment. Accuview (registered trademark) Advance (registered trademark) (BC: 8.3, Dia: 14.0, Power: -0.50) Johnson End Johnson, Inc .: Silicone hydrogel contact lens (hereinafter abbreviated as AA) and One Day AccuBue True Eye (registered trademark) (BC: 8.5, Dia: 14.2, Power: -0.50; Johnson End A product manufactured by Johnson: Silicone hydrogel contact lens (hereinafter abbreviated as TrE) was prepared. As a representative example of a soft contact lens subjected to plasma CVD as a surface treatment, Air Optics (registered trademark) Aqua (BC: 8.6, Dia: 14.2, Power: -0.50; Ciba Vision Co., Ltd.) Manufactured: Silicone hydrogel contact lens (hereinafter abbreviated as AO). For these test contact lenses, the refractive index was measured by a general measurement method according to JIS K0062. That is, about each contact lens for a test, after immersing in each liquid agent of Examples 1-97 and Comparative Examples 1-21 and physiological saline for 4 hours, respectively, using an Abbe refractometer (1T made by Atago Co., Ltd.) The refractive index (sodium-D line) at 20 ° C. of a test contact lens (a contact lens having an apex refractive power of −0.50 D) was measured.

Each solution and physiological saline was measured 5 times using 5 test contact lenses. The refractive index obtained for each solution is increased with respect to the refractive index (AA: 1.050, TrE: 1.4043, AO: 1.4235) of each test contact lens immersed in physiological saline. The rate was evaluated by obtaining the following equation. In Tables 8 to 26, the average value of the refractive index increase rate measured five times for each liquid was listed.
[Formula 1]
Refractive index increase rate (%) = ({(refractive index when using each liquid agent) / (refractive index when using physiological saline)}-1) × 100

  From Tables 8 to 26, when the contact lens mounting solutions of Examples 1 to 97 are used, in any of the test contact lenses, 0.20% to 2.49 compared to the case where physiological saline is used. % (Less than 2.5%) is ensured (see Examples 13, 36, 48, 54, 55, 76, 96, 97, etc.), and the refraction by the contact lens mounting liquid according to the present invention. It can be seen that the rate improvement function is stably exhibited. In addition, by setting the ratio to less than 2.5%, the vertex refractive power (D) of the attached contact lens is prevented from changing greatly from, for example, a contact lens that is normally −3.00D to more than −0.25D. it can. In particular, 0.50% to 2.49% (see Examples 16, 31, 76, 97, etc.) for AA and TrE, which are test contact lenses made of silicone hydrogel not subjected to surface treatment. Thus, it was confirmed that the function of improving the refractive index of the present invention is advantageously exerted on a contact lens made of silicone hydrogel that is not subjected to surface treatment.

  On the other hand, in Comparative Examples 5, 8, 11, 16, 17, 20, and 21, which contain the component (B) but do not contain any component (A), the refractive index increase rate is 0.00% to 0.02. It was confirmed that the refractive index improving function was hardly exhibited. In addition, in the case of Comparative Examples 7, 10, 13 in which the blending amount of each component used among the components (A) exceeds 0.0025% by weight, and the blending amount in the case where two or more components (A) are selected. In the case of Comparative Examples 6, 9, 12, 14, 15, 18, 19 in which the sum of the values exceeds 0.015%, the refractive index increase rate is 2.5% or more, and there is a problem of creating overcorrection. It was confirmed that there was.

[Examples 98 to 160, Comparative Examples 22 to 60]
According to the composition table of the following Tables 27 to 40, each component in the table was dissolved in purified water according to a conventional method, pH was adjusted, and then each solution was sterile filtered to prepare a contact lens mounting solution. The same tests as those described above were carried out for the solutions and purified water obtained in Examples 98 to 160 and Comparative Examples 22 to 60 (Japanese Pharmacopoeia purified water (contained in Nikon Pharmaceutical Co., Ltd.)). did. In the following description,% by weight (W / V%) is the same as g / 100 mL. In addition, each component of flavin adenine dinucleotide sodium, cyanocobalamin, acetic acid retinol, retinol palmitate, pyridoxine hydrochloride, panthenol, calcium pantothenate, sodium pantothenate and tocopherol acetate shown in Tables 27 to 40 is the component (A). Yes, each component of polyvinyl alcohol, hypromellose and polyvinylpyrrolidone is the component (B). In the table, polyvinyl alcohol (partially saponified product) is VP-18 (manufactured by Nippon Vinegar Poval Co., Ltd.). Hypromellose is METOLOSE 60SH-4000 (manufactured by Shin-Etsu Chemical Co., Ltd.). As the polyvinylpyrrolidone, Kollidon 30 (manufactured by BASF) was used.

  As a representative example of a soft contact lens not subjected to surface treatment, a test contact lens is a Menicon 1DAY flat pack (registered trademark) (BC: 8.6, Dia: 14.2, Power: -0.50; Manufactured by Menicon Co., Ltd., hereinafter abbreviated as FP). Further, as a representative example of a soft contact lens subjected to plasma treatment as a surface treatment, 2WEEK Menicon Premio (registered trademark) (BC: 8.6, Dia: 14.0, Power: -0.50; Co., Ltd.) Menicon manufactured silicone hydrogel contact lens; hereinafter abbreviated as MP). For these test contact lenses, the refractive index was measured by a general measuring method according to JIS K0062, as described above. That is, each test contact lens was immersed in each solution of Examples 98 to 160 and Comparative Examples 22 to 60 and purified water for 4 hours, and then each test was performed using an Abbe refractometer (1T manufactured by Atago Co., Ltd.). The refractive index (sodium-D line) at 20 ° C. of the contact lens for use was measured.

Each solution and purified water was measured 5 times using 5 test contact lenses. The refractive index obtained for each solution is based on the refractive index (MP: 1.4069, FP: 1.3969) of each test contact lens soaked in purified water, and the rate of increase with respect to it is given by [Equation 2]. Evaluated by seeking. In Tables 27 to 40, the average value of the refractive index increase rate measured five times for each liquid was listed.
[Formula 2]
Refractive index increase rate (%) = ({(refractive index when using each liquid agent) / (refractive index when using purified water)}-1) × 100

  From Tables 27 to 40, if the contact lens mounting solutions of Examples 98 to 160 were used, 0.05% to 3.3% of any test contact lens compared to the case where purified water was used. (See Examples 128, 131, 153, etc.), it can be seen that the function of improving the refractive index by the contact lens mounting liquid according to the present invention is stably exhibited. In particular, FP, which is a contact lens that has not been subjected to surface treatment, has a higher refractive power increase rate than MP, which is a contact lens that has been subjected to surface treatment, and improves the refractive index of the present invention. It was confirmed that the function is exerted advantageously.

  On the other hand, in Comparative Examples 40 to 45 that contain the component (B) but do not contain any component (A), the refractive index increase rate is 0% to 0.02%, and the function of improving the refractive index is almost achieved. It was confirmed that it was not demonstrated. Moreover, the sum of the blending amounts in the case of Comparative Examples 22 to 30 in which the blending amount of each component used in the component (A) exceeds 0.0025% by weight and when two or more (A) components are selected. In Comparative Examples 31 to 33 exceeding 0.015%, the refractive index increase rate exceeded 3.3%, and it was confirmed that there was a problem of overcorrection.

  In addition, as shown in Tables 39 and 40, for examples (comparative examples 47 to 60) containing pranoprofen, acitazanolast, tranilast, anhydrous caffeine, berberine chloride, lomefloxacin hydrochloride, and zinc sulfate in the composition, Even if a small amount of these is included, it has been confirmed that the refractive index improvement rate of the contact lens becomes excessive. Moreover, although description to a table | surface is omitted, the refractive index improvement rate of the contact lens became excessive similarly also when things other than cyanocobalamin were used as (A) component. On the other hand, after measuring the refractive index of the contact lens immersed in these comparative examples for 4 hours, the contact lens was further immersed in purified water for 4 hours, and then the refractive index of the contact lens was measured. It did not return to the value of the refractive index of the contact lens as a control, and maintained a relatively high refractive index. Therefore, since it was suggested that these components are selectively taken in and remain in the contact lens, it can be determined that the formulation of the component should be avoided in the contact lens mounting liquid according to the present invention.

[Bacterial adhesion suppression function test]
The same five types of test contact lenses as those for the refractive index improvement function test were prepared, and the following procedures were used.
(1) In order to remove the circulation preservation solution or the like attached to each test contact lens, each test contact lens is treated with 5 mL of a physiological saline solution (hereinafter referred to as ISO physiological saline) defined by ISO18369-3 (2006). ) For 8 hours or more.
(2) Each solution of Examples 1 to 160 and Comparative Examples 1 to 60 and ISO physiological saline were placed in each well of a 24-well cell culture multiplate (hereinafter referred to as multiplate) in a volume of 1 mL.
(3) After the moisture on the surface of each test contact lens taken out from the ISO physiological saline is blotted with a paper waste (Kimwipe (registered trademark): manufactured by Nippon Paper Crecia Co., Ltd.), each solution and the ISO physiological saline are One contact lens for each test was placed in the multiplate.
(4) After 3 minutes, each test contact lens is removed from each multiplate using sterilized tweezers, and the water on the surface of each test contact lens is lightly cut off from the edge of the well, and then 1 × 10 ⁸ CFU / mL. Pseudomonas aeruginosa ATCC9027 bacterial solution (suspended in ISO physiological saline) 5 mL prepared in the above was placed in a 6-well multiplate and stored at room temperature for 30 minutes.
(5) Next, each test contact lens is taken out using sterilized tweezers, and in order to remove excess bacteria in contact with each lens, a 12-well multiplate containing 5 mL of ISO physiological saline is used. Each test contact lens was placed and shaken with tweezers for 1 minute.
(6) Next, each test contact lens is transferred to a plastic centrifuge tube containing 5 mL of new ISO physiological saline, subjected to ultrasonic waves (38 kHz) for 3 minutes, and then stirred for 1 minute with a test tube mixer. Then, bacteria attached to each soft contact lens were peeled off, and each adherent bacterial solution was collected.
(7) The adherent bacterial solution obtained from each test contact lens is diluted to an appropriate concentration for measurement, seeded on a viable count medium (SCD agar medium), and 1 at 33 ° C. After the overnight culture, the number of colonies observed was counted, and the number of bacteria attached to each lens (viable cell count) was determined by correcting with the dilution factor.

Each solution and ISO physiological saline was measured 5 times using 5 test contact lenses. The number of attached bacteria obtained for each solution was evaluated by determining the bacterial adhesion inhibition rate (%) according to the following formula 3 based on the number of attached bacteria of each test contact lens immersed in ISO physiological saline. . In Tables 8 to 26 and Tables 27 to 40, the average values of the number of attached bacteria measured 5 times for each solution are listed.
[Formula 3]
Bacterial adherence inhibition rate (%) = {1− (the number of adherent bacteria when using each solution) / (the number of adherent bacteria when using ISO physiological saline)} × 100

  From Tables 8 to 40, if the contact lens mounting solutions of Examples 1 to 160 were used, 5% to 49% of bacteria in any test contact lens compared to the case where ISO physiological saline was used. It is confirmed that the adhesion suppression rate is ensured (see Examples 16, 59, 128, 149, 151, 155, etc.) and the bacterial adhesion suppression function by the contact lens mounting liquid according to the present invention is stably exhibited. did it. In particular, when comparing the presence or absence of the surface treatment of the contact lens, in the case of AA, TrE, and FP, which are contact lenses that are not subjected to the surface treatment, than the silicone hydrogel lenses (AO, MP) that are subjected to the surface treatment. It was also confirmed that the effect of suppressing bacterial adhesion was remarkably exhibited. In addition, since water is used as a solvent in the present embodiment, water-soluble flavin adenine dinucleotide sodium, cyanocobalamin, pyridoxine hydrochloride, panthenol, calcium pantothenate, and sodium pantothenate are used as a component in the formulation design. More preferably, on the other hand, especially when each component of component (A) is included at 0.0020 to 0.0025%, a bacterial adhesion inhibition rate of 10% to 49% is secured. (See Examples 41, 45, 59, 124, 155, etc.), it was confirmed that the bacterial adhesion suppression function by the contact lens mounting liquid according to the present invention was exhibited more advantageously. In addition, when two or more types of component (A) are selected and the sum of their blending amounts is less than 0.015%, a high bacterial adhesion inhibition rate of 10% to 26% is demonstrated. (See Examples 19, 38, 57, 76, 77, 96, 97, 152 to 154, etc.). In addition, although there is no significant difference in the bacterial adhesion inhibition rate depending on the type of component (B), the bacterial adhesion inhibition rate is slightly different when polyvinyl alcohol is selected or when polyvinyl alcohol and hypromellose are used in combination. However, there was a tendency to improve. (See Examples 99, 155, 158, etc.).

  On the other hand, in the case of Comparative Examples 1 to 4 and Comparative Examples 34 to 39 that contain the component (A) at a predetermined blending amount but do not contain the component (B), the bacterial adhesion inhibition rate is -7% to 0%. It was confirmed that not only a sufficient bacterial adhesion inhibition rate could not be obtained, but also the effect was attenuated. Furthermore, in the case of Comparative Examples 6, 7, 9, 10, 12 to 15, 18, 19, 22 to 30 including the component (A) in a predetermined amount or more, the component (B) is included. It was confirmed that the effect was attenuated as compared with the case (comparison between Example 2 and Comparative Example 7). Moreover, in the case of the comparative examples 5, 8, 11, 40-46 which do not contain (A) component but contain (B) component, it has remained in the bacterial adhesion suppression rate of 0%-1%, and sufficient bacterial adhesion suppression rate It was confirmed that cannot be obtained. Furthermore, about the case where the component which may have a bad influence with respect to a contact lens shown to Comparative Examples 47-60 was mix | blended, even if (A) component and (B) component contained the predetermined compounding quantity. However, it was also confirmed that the bacterial adhesion inhibition rate could not be sufficiently obtained. In this example, it is clear that the same effect as described above appears even when a fashionable contact lens (including non-silicone hydrogel and silicone hydrogel material) manufactured by a sandwich manufacturing method is used. .

[Examples 161-214, Comparative Examples 61-138]
According to the composition table of the following Tables 41 to 59, each component in the table was dissolved in purified water according to a conventional method, pH was adjusted, and then each solution was sterile filtered to prepare a contact lens mounting solution. The following tests were carried out for each of the solutions of Examples 161 to 214 and Comparative Examples 61 to 138 obtained. In the following description,% by weight (W / V%) is the same as g / 100 mL. In addition, each component of flavin adenine dinucleotide sodium, cyanocobalamin, retinol palmitate, pyridoxine hydrochloride, calcium pantothenate, and tocopherol acetate shown in Tables 41 to 59 is component (A), and polyvinyl alcohol, hypromellose, polyvinylpyrrolidone Each component is the component (B). In the table, polyvinyl alcohol (partially saponified product) is Gohsenol EG-05 (manufactured by Nippon Synthetic Chemical Co., Ltd.). Hypromellose is METOLOSE 60SH-50 (manufactured by Shin-Etsu Chemical Co., Ltd.). As the polyvinylpyrrolidone, Kollidon 30 (manufactured by BASF) was used.

[Water transpiration suppression effect test]
In general, contact lenses are packaged in a circulating storage solution, and in the case of non-reusable disposables, the lens is taken out from the package and worn as it is, or a solution such as a contact lens mounting solution or a contact lens rinsing solution is used. It is worn after contacting. In particular, in the case of the latter form of use, the distribution storage solution and the contact lens mounting solution are directly contacted and mixed. In addition, on the first day of wear, contact lenses that are regularly exchanged or frequently exchanged, such as a two-weekly exchangeable type, are in direct contact with the liquid stock solution and the contact lens mounting liquid as in the above-mentioned reusable type. Although it is mixed, it is used after being stored in a contact lens sterilizing solution (multipurpose solution (hereinafter referred to as MPS) or the like) on a subsequent wearing day. Therefore, the MPS or the like and the contact lens mounting liquid are directly contacted and mixed. The following tests take into account two cases: (1) the case of non-reusable disposable contact lenses (contact with circulating stock solution) and (2) the case of two-week exchangeable contact lenses (contact with MPS). Carried out. After the following pretreatment was performed as test contact lenses, these six types were subjected to the test (Tables 41 to 59).
(1) In the case of non-reusable disposable contact lenses (i) Boric acid-containing distribution stock solution lens (1A)
1D Accuview (registered trademark) (BC: 9.0, DIA: 14.2, POWER: -3.00; manufactured by Johnson &Johnson; non-reusable disposable contact lens) The following process 1 is performed, and the specimen is referred to as “boric acid blended distribution preservation solution lens (1A)”.
(Ii) Boric acid-containing distribution stock solution lens (TrE)
-1D AccuBu True Eye (BC: 9.0, DIA: 14.2, POWER: -3.00; manufactured by Johnson &Johnson; non-reusable disposable contact lenses). The following process 1 is performed, and the specimen is referred to as a “boric acid-containing circulation stock solution lens (TrE)”.
(Process 1)
As a pretreatment of the contact lens of (i) and (ii) above, each test contact lens is taken out of the package, and in order to remove the influence of the circulating preservation solution in the package, 8% in ISO physiological saline adjusted to 20 ° C. Soaked for hours. Thereafter, the lens was taken out and rinsed with ISO physiological saline, and then a boric acid-based preservation solution (boric acid 1.0%, sodium chloride 0.33%, pH = 7.3 (0.05 mol / L sodium hydroxide) Adjusted with aqueous solution), osmotic pressure ratio = 1) Each piece was immersed in a pressure-resistant heat-resistant bottle containing 5 mL. Thereafter, dry heat steam sterilization was performed at 121 ° C. for 20 minutes.
(Iii) Boric acid-free distribution stock solution lens (1A / N)
1A (BC: 9.0, DIA: 14.2, POWER: −3.00; manufactured by Johnson &Johnson; non-reusable disposable contact lens). The following processing is performed, and the specimen is referred to as “boric acid non-blending distribution stock solution lens (1A / N)”.
(Iv) Boric acid-free distribution stock solution lens (TrE / N)
TrE (BC: 9.0, DIA: 14.2, POWER: −3.00; manufactured by Johnson &Johnson; non-reusable disposable contact lens). The following processing is performed, and the specimen is referred to as “boric acid non-blending distribution stock solution lens (TrE / N)”.
(Process 2)
As a pretreatment of the contact lens of (iii) and (iv) above, each test contact lens was taken out of the package and immersed in ISO physiological saline adjusted to 20 ° C. for 8 hours. Thereafter, the lens was taken out, rinsed with ISO physiological saline, and then immersed one by one in a pressure-resistant heat-resistant bottle containing 5 mL of ISO physiological saline. Thereafter, dry heat steam sterilization was performed at 121 ° C. for 20 minutes.
(2) In the case of a two-week exchangeable contact lens (v) A lens using MPS containing boric acid (AA)
AA (BC: 8.7, DIA: 14.0, POWER: −3.00; manufactured by Johnson &Johnson; two-week exchangeable contact lens).
As a pretreatment of the contact lens of (v) above, the contact lens was removed from the package and immersed in ISO physiological saline adjusted to 20 ° C. for 8 hours in order to eliminate the influence of the circulating storage solution. Thereafter, the lens was taken out and rinsed with ISO physiological saline. Then, MPS containing boric acid (polyhexanide hydrochloride: 1 ppm, boric acid: 0.5%, sodium chloride: 0.55%, sodium edetate: 0.011% Poloxamer 407: 0.25%, sodium hydroxide: appropriate amount (pH = 7.3 amount), purified water: appropriate amount) for 4 hours at room temperature, one by one contact lens case (made of polypropylene, 5 mL Stored). The obtained specimen was referred to as “Boric acid-containing MPS use lens (AA)”.
(Vi) MPS use lens without boric acid (AA / N)
AA (BC: 8.7, DIA: 14.0, POWER: −3.00; manufactured by Johnson &Johnson; two-week exchangeable contact lens).
As a pretreatment of the contact lens of (vi) above, the contact lens was taken out of the package and immersed in ISO physiological saline adjusted to 20 ° C. for 8 hours in order to eliminate the influence of the circulating stock solution. Thereafter, the lens was taken out and rinsed with ISO physiological saline, and then borated MPS (polyhexanide hydrochloride: 1 ppm, sodium hydrogen phosphate: 0.5%, sodium chloride: 0.60%, sodium edetate: 0 0.11%, Poloxamer 407: 0.25%, Sodium hydroxide: appropriate amount (amount to reach pH = 7.3), purified water: appropriate amount) for 4 hours at room temperature, one by one contact lens case (polypropylene) And 5 mL volume). The obtained specimen was referred to as “Boric acid non-compounding MPS use lens (AA / N)”.

About each test contact lens by which the pre-processing was carried out as mentioned above, the moisture transpiration suppression effect was measured as follows. First, the surface of each test contact lens was wetted with liquid droplets of Examples 161 to 214 and Comparative Examples 61 to 138, then placed on an electronic balance, and the change in weight was measured every minute for 15 minutes. The measurement was carried out in a constant temperature and humidity room adjusted to 25.0 ° C. and 30 RH%. For each test solution, five experiments were performed using five lenses. Based on the obtained measurement results, the weight change rate (%) was calculated from Equation 4 and plotted against time (t). The slope of the obtained plot was obtained from an approximate expression by the least square method, and the moisture transpiration suppression effect was obtained from Expression 4. In addition, the liquid agent of the comparative example 74 used by Formula 5 is a liquid agent which does not contain any of (A) component (B) component. It shows that the moisture transpiration from a contact lens is suppressed, so that the value of the moisture transpiration suppression effect degree is large.
[Formula 4]
Weight change rate (%) = lens weight after t minutes (g) / lens weight at the start of measurement (g) × 100
[Formula 5]
Moisture transpiration suppression effect = (1−gradient of weight change rate under each test condition / gradient of weight change rate when using liquid agent of Comparative Example 74) × 100

  From Tables 41 to 56, when the contact lens mounting solutions of Examples 161 to 214 were used, lenses immersed in a contact lens distribution storage solution containing boric acid (boric acid-containing distribution storage solution lens (1A), ( TrE)) is effective in suppressing moisture transpiration of lenses immersed in a contact lens circulation preservation solution that does not contain boric acid (boric acid-free circulation preservation solution lenses (1A / N), (TrE / N)). It was confirmed that it was significantly higher than the suppression effect. Similarly, when the contact lens mounting liquids of Examples 161 to 214 were used for the lens using boric acid-containing MPS (lens using boric acid-containing MPS (AA)), the non-boric acid-containing MPS was used. Compared with the case of a lens (lens not containing boric acid MPS (AA / N)), the water evaporation suppression effect was extremely high.

  On the other hand, in Comparative Examples 68 to 73, 75 to 80, 88 to 99, and 107 to 124 that include the component (A) in the specified range of the present invention but do not include the component (B), the moisture transpiration is suppressed more than in Comparative Example 74. It was confirmed that the effectiveness was equal or rather worse. In Comparative Examples 61 to 66, 81 to 86, and 100 to 105 including the component (B) exceeding the specified range of the present invention, moisture transpiration even in the case of boric acid blending. It was found that the inhibitory effect level was not greater than 17, the sufficient moisture transpiration inhibitory effect was not exhibited, and the moisture transpiration inhibitory effect level tended to increase due to the large amount of component (A). In addition, in Comparative Examples 67, 87, and 106 that contain the component (B) but do not contain the component (A), even when boric acid is blended, the moisture transpiration suppression effect does not exceed 15, and sufficient moisture content is obtained. It was found that no transpiration control effect was obtained. Furthermore, although both component (A) and component (B) are included in the specified range, a comparison that includes any of pranoprofen, tranilast, acitazanolast, anhydrous caffeine, berberine chloride, lomefloxacin hydrochloride, or zinc sulfate as other components In Examples 125 to 138, it was found that the water transpiration suppressing effect was rather attenuated as compared with the case where these components were not included (Example 164). As described above, Examples 161 to 214 show examples of non-reusable disposable contact lenses in which boric acid is blended with a circulation preservation solution and two-week exchangeable contact lenses treated with care products containing boric acid. It was confirmed that the contact lens mounting liquid agent can provide an excellent effect of suppressing moisture transpiration.

  In addition, when retinol acetate is used as the component (A), substantially the same effect as that of retinol palmitate, which is the same retinol derivative, is obtained, and panthenol or sodium pantothenate is used as the component (A). In this case, it is clear that substantially the same effect as that of calcium pantothenate, which is the same panthenol derivative, can be obtained, which is the same as the case of the refractive index improvement function test and the bacterial adhesion suppression function test.

Claims (7)

As the component (A), flavin adenine dinucleotide sodium, cyanocobalamin, retinol acetate, pyridoxine hydrochloric acid, panthenol, calcium pantothenate, sodium pantothenate, at least one selected from tocopherol acetate, each 0.00005 to 0. When two or more kinds are selected at 0025% by weight, the sum of the blending amounts is less than 0.015% by weight,
(B) as a component contains at least one selected from polyvinyl alcohol, hypromellose, polyvinylpyrrolidone, and
Contact characterized by not containing any of pranoprofen, tranilast, acitazanolast, anhydrous caffeine, berberine chloride, lomefloxacin hydrochloride, zinc sulfate , retinol palmitate, chlorobutanol, phenylethyl alcohol, benzyl alcohol, ethanol Lens mounting fluid.   The contact lens refractive index is improved by 0.05% or more and 3.3% or less with respect to the contact lens refractive index at 20 ° C. when purified water is adhered to the contact lens. The liquid for contact lens mounting of description.   The contact lens mounting solution according to claim 1 or 2, wherein the contact lens is a contact lens that is not subjected to a surface treatment.   The contact lens mounting solution according to any one of claims 1 to 3, wherein the contact lens is a soft contact lens immersed and stored in a contact lens circulation storage solution containing boric acid.   The contact lens mounting solution according to any one of claims 1 to 4, wherein the contact lens is a soft contact lens mounted after being treated with a care product containing boric acid.   The contact lens mounting liquid according to any one of claims 1 to 5, which is used as at least one selected from a contact lens mounting drug, a contact lens rinsing liquid, and a contact lens circulation preserving liquid. As component (A), at least one selected from flavin adenine dinucleotide sodium, cyanocobalamin, retinol acetate, retinol palmitate, pyridoxine hydrochloride, panthenol, calcium pantothenate, sodium pantothenate, tocopherol acetate, 0.00005 each. -0.0025 wt%, when two or more types are selected, the sum of their amounts is less than 0.015 wt%, and
(B) as a component contains at least one selected from polyvinyl alcohol, hypromellose, polyvinylpyrrolidone, and
Using a contact lens mounting solution that does not contain any of pranoprofen, tranilast, acitazanolast, anhydrous caffeine, berberine chloride, lomefloxacin hydrochloride, zinc sulfate, and before mounting the contact lens, the contact lens mounting solution, A method for improving the refractive index of a contact lens, wherein the contact lens is brought into contact with the contact lens.