JP5033657B2 - Contact lens solution, contact lens, and antibacterial agent prevention method for contact lens - Google Patents

Description

  The present invention relates to a contact lens solution, a contact lens, and a method for preventing the adhesion of a bactericidal agent to a contact lens, and more particularly to a technique that can effectively suppress or prevent the bactericidal agent from adhering to a contact lens.

  Conventionally, in order to use contact lenses safely and comfortably, contact lens care, such as cleaning treatment to remove proteins and eye grease adhering to contact lenses, and sterilization treatment to prevent the growth of microorganisms, etc. Has been done on a daily basis. In such contact lens care, care products corresponding to the material and type of the contact lens are usually used. In recent years, in particular, a contact lens cleaning process, a rinsing process, and a disinfecting process with one liquid agent. Multipurpose solution (MPS) that can perform all of the storage processing is easier and more convenient than conventional care products that require complicated processing such as boiling and hydrogen peroxide neutralization. Since it is excellent, it is rapidly spreading.

  Such MPS usually contains polyhexamethylene biguanide (PHMB), benzalkonium chloride, etc. in order to prevent the growth of microorganisms in the liquid and the contamination of the contact lenses by microorganisms, and to keep the contact lenses clean. Although the cationic polymer bactericidal agent is added to the contact lens treated with the MPS, other liquid agents are used because the content is suppressed to a very small amount (about 1 to 10 ppm). It is allowed to be worn directly on the eyes without rinsing.

  However, recent studies have shown that eye damage such as corneal epithelial damage may be caused by a cationic polymer fungicide contained in MPS in a very small amount, particularly PHMB. This is because the contact lenses (especially silicone hydrogel contact lenses) are treated with a hydrophilic surface to improve tear wettability, so that the contact lenses themselves can easily incorporate cationic polymer disinfectants. It is speculated that this is caused by the fact that More specifically, when the contact lens is subjected to a surface hydrophilization treatment, for example, an OH group or an anionic group is formed on the surface of the contact lens. It is thought that the disinfectant is easily attached or adsorbed. For this reason, even if the concentration of the bactericidal agent contained in MPS is kept low, the bactericidal agent is impregnated or adsorbed on the inside or surface of the contact lens and accumulated by daily contact lens care using MPS, and It is presumed that the accumulated bactericidal agent is released onto the surface of the eye by tears after wearing the contact lens, causing eye irritation and eye damage. Therefore, as one of the measures for solving the problem of eye damage caused by the bactericidal agent, it is required to prevent the bactericidal agent from adhering to the contact lens without weakening the bactericidal effect of the bactericidal agent. .

  By the way, Patent Document 1 discloses a contact lens for cleaning a dirt adhered to a contact lens and further imparting hydrophilicity to the surface of the contact lens to prevent the dirt from being reattached and to improve the wearing feeling of the contact lens. In order to provide a solution, a contact lens solution containing a water-soluble cationized polymer and a surfactant has been proposed. In this case, the surface of the lens is imparted with hydrophilicity to prevent the reattachment of dirt. However, some investigations have been made regarding the problems caused by the disinfectant adhering to the contact lens. No. Patent Documents 2 and 3 propose a method in which a cationic polysaccharide is brought into contact with the surface of a biomedical device in order to prevent adhesion of bacteria to the surface of a biomedical device such as a contact lens. Even in this case, as in the above-mentioned Patent Document 1, no consideration has been given to the problem caused by the disinfectant adhering to the contact lens.

  Patent Document 4 clearly discloses a method of treating a contact lens surface with a cationic polysaccharide (cationic polysaccharide) for the purpose of inhibiting the ability of a biomaterial such as a contact lens to absorb an antibacterial agent. However, in the method disclosed in Patent Document 4, even if a cationic polysaccharide is coated on the surface of the contact lens, it can be easily removed, so that the antibacterial agent can be permanently prevented from adhering to the contact lens. The effect was not obtained so much and there was still room for improvement.

JP 2000-347145 A Special table 2004-517653 gazette JP-T-2004-537348 JP-T-2004-515813

  Here, the present invention has been made in the background of such circumstances, and the problem to be solved is to effectively suppress or prevent adhesion of the bactericide to the contact lens. It is an object of the present invention to provide a contact lens solution that can be prevented, and to provide a contact lens in which such disinfectant can be prevented from adhering, and to prevent adhesion of the disinfectant to the contact lens. There is also to provide a method.

  Then, as a result of extensive studies by the present inventors to solve the above-described problems, the contact lens is immersed in a contact lens solution containing a specific polymer component and subjected to a predetermined heating operation. Therefore, the present inventors have found that the disinfectant is less likely to adhere and have completed the present invention.

That is, the present invention is a contact lens solution which is used by being heated to a temperature of at least 60 ° C. or more under the condition that the contact lens is immersed for the above-mentioned problem, groups have a and nitrogen content having a nitrogen atom as a cationic group is 0.1 to 40 wt% der Ru cationic polymer and / or (B) degree of saponification: 99.4 mol% or more polyvinyl alcohol, sterilization The gist of the liquid agent is a contact lens solution characterized by being contained as an agent adhesion preventing agent.

In the contact lens solution according to the present invention, a quaternary ammonium group is preferably selected as the group having a nitrogen atom of the cationic polymer (A).

Further, according to one preferred embodiment of the contact lens liquid agent according to the present invention, as the cationic polymer is selected from the group consisting of cationized cellulose, cationized polyvinyl pyrrolidone, cationic starch, cationic dextran, and polyquaternium It is.

  In addition, in the contact lens solution according to the present invention, as a distribution stock solution used when packaging new contact lenses that are shipped from manufacturers and provided to users (consumers) through a distribution process, It will be used advantageously.

  In the present invention, the antibacterial agent is adhered by heating to a temperature of at least 60 ° C. in a state immersed in the contact lens solution as described above. Contact lenses are also the gist.

  The present invention also provides that the antibacterial agent is adhered to the contact lens by immersing the contact lens in the contact lens solution as described above and then heating the contact lens to a temperature of at least 60 ° C. or higher. The gist of the method for preventing the disinfectant from adhering to the contact lens is also a gist thereof.

  In addition, according to the method for preventing adhesion of a bactericidal agent to a contact lens according to the present invention, when a biguanide type and / or quaternary ammonium type bactericidal agent is used as the bactericidal agent, its adhesion can be advantageously prevented. Become.

Thus, in the contact lens solution according to the present invention, (A) a polymer having a cationic group in the molecule and (B) a saponification degree: 99.4 mol% or more of polyvinyl alcohol as the antibacterial agent And at least 60 ° C. in a state in which the contact lens is immersed, such a component is firmly attached to the contact lens. Since it is fixed or bonded, adhesion of the bactericide to the contact lens can be effectively prevented or suppressed.

  More specifically, by immersing the contact lens in the contact lens solution according to the present invention, heating the contact lens solution and the contact lens to a temperature of 60 ° C. or higher, and applying thermal energy, the above-mentioned The polymer having a cationic group (A) and / or the polyvinyl alcohol (B) can be firmly fixed or bonded to the surface or inside of the contact lens. As a result, the contact lens subjected to such immersion / heating treatment is immersed in a contact lens / care solution (eg, MPS) containing a bactericide such as a biguanide bactericide or a quaternary ammonium bactericide. Even so, it is possible to effectively prevent or suppress the disinfectant contained in the contact lens / care solution from adhering to the contact lens. That is, in a contact lens immersed in the liquid for contact lenses according to the present invention and heat-treated at 60 ° C. or higher, a contact lens to which bactericides such as biguanide bactericides and quaternary ammonium bactericides easily adhere. Is immersed in a contact lens / care solution containing a bactericidal agent from the point where the part is coated with a polymer having a cationic group as the component (A) and / or polyvinyl alcohol as the component (B) in advance. Even so, the attachment of such disinfectants is effectively blocked, and the anti-adhesion effect is advantageously realized and can be sustained.

  As a result, when the contact lens solution according to the present invention is used, it is possible to advantageously avoid the disinfectant from adhering to the contact lens. No problems such as eye damage caused by the agent are caused.

  Further, even in the contact lens according to the present invention and the antibacterial agent prevention method for the contact lens, the contact lens is immersed in the contact lens solution as described above, and heat treatment is performed. The effect of preventing the disinfectant from being attached can be enjoyed advantageously.

By the way, the liquid agent for contact lenses according to the present invention is (A) a polymer having a cationic group in the molecule as an antibacterial agent preventing agent in an aqueous medium mainly composed of water (hereinafter referred to as a cationic polymer). And (B) Saponification degree: It is comprised by melt | dissolving and making it contain any one or both of 99.4 mol% or more of polyvinyl alcohol (PVA).

  Here, the cationic polymer of the component (A) is applicable to any structure as long as it has excellent compatibility with contact lenses and low toxicity to the eye and has a cationic group. For example, the polymer main chain skeleton has a cationic group, the polymer side chain has a cationic group, or both the polymer main chain skeleton and side chain. May have a cationic group. Moreover, even if it exists in this cationic group, although it does not specifically limit, in particular, what has a quaternary ammonium group is used suitably in this invention.

  Here, specific examples of the cationic polymer of the component (A) include cationized cellulose, cationized polyvinylpyrrolidone, cationized starch, cationized dextran, polyquaternium, cationized guar gum, cationized chitosan, cationized PVA, phosphorus Lipid polymers, polyethyleneimine, ε-polylysine and the like can be mentioned, and one of these cationic polymers can be used alone, or two or more thereof can be used in combination.

  More specifically, as the cationized cellulose, polyquaternium-10 or polyquaternium-67 having a cationic group in the side chain of hydroxyethylcellulose is preferably used. The cationized dextran preferably has a weight average molecular weight in the range of 10,000 to 1,000,000, and the cationized chitosan preferably has a weight average molecular weight in the range of 35,000 to 350,000. is there. Furthermore, specific examples of polyquaternium include polyquaternium-10 (cationized cellulose) having a cationic group in the side chain, polyquaternium-67 (cationized cellulose), polyquaternium-51 (phospholipid polymer), and cation in the main chain skeleton. Examples thereof include polyquaternium-6, polyquaternium-7, and polyquaternium-22 having a group.

  In addition, when a polymer having a cation group having a nitrogen atom such as a quaternary ammonium group, a tertiary ammonium group, a secondary ammonium group, or a primary ammonium group is used as the cationic polymer, the nitrogen content thereof However, it is generally desirable to be about 0.1 to 40% by weight, preferably about 0.5 to 35% by weight. By using such a polymer, the surface of the contact lens can be further coated with the cationic polymer. It can be done effectively. If the nitrogen content is too small, the cationic polymer has a low degree of cationization, and the contact lens may not be sufficiently covered with the cationic polymer. On the other hand, if the nitrogen content is too high, the contact lens may not be sufficiently covered due to electrical repulsion between the cationic polymers, which is not desirable.

On the other hand, as the polyvinyl alcohol of the component (B), polyvinyl alcohol having a saponification degree of 99.4 mol% or more is used, whereby the polyvinyl alcohol is effectively fixed or bonded to the contact lens surface. Doo ing. Contact name if the saponification degree is not sufficient, the content of OH groups of the polyvinyl alcohol is decreased, polyvinyl alcohol is difficult to firmly fixed to the coupling to the contact lens surface, adhesion preventing effect of fungicides Can not get enough.

  In the present invention, the polyvinyl alcohol having the saponification degree as described above is not particularly limited. However, from the viewpoint of the feeling of use of the liquid agent for contact lenses, it is 20 ° C., 4 w / w. % Having a kinematic viscosity of 4 to 70 mPa · s is more preferably used.

  In the contact lens solution according to the present invention, at least one of the above-mentioned (A) cationic polymer and (B) polyvinyl alcohol is contained, particularly preferably (A) cationic. Both the polymer and (B) polyvinyl alcohol will be contained.

  Here, the content of the cationic polymer of the component (A) is not particularly limited, and may be appropriately set according to the type of contact lens or the type of the cationic polymer. However, preferably, a concentration range of 0.0001 to 1 w / w% (weight%), more preferably 0.001 to 0.1 w / w%, is advantageously employed. If the content of the cationic polymer is too small, the effect of the addition may not be sufficiently exhibited. Conversely, if the content of the cationic polymer is too large, the viscosity of the liquid agent becomes high. This is not desirable because the diffusion of the cationic polymer is lowered and a sufficient effect may not be obtained.

  On the other hand, even if it is in the content of the polyvinyl alcohol of the component (B), it is not particularly limited, and may be appropriately set according to the type of contact lens to be targeted, the degree of saponification of polyvinyl alcohol, and the like. However, preferably, a concentration range of 0.0001 to 1 w / w%, more preferably 0.001 to 0.1 w / w%, is advantageously employed. If the content of the polyvinyl alcohol is too small, the effect of the addition may not be sufficiently exhibited. Conversely, if the content of the polyvinyl alcohol is too large, the viscosity of the liquid agent becomes too high. This is not desirable because the diffusion of polyvinyl alcohol is lowered and a sufficient effect may not be obtained.

  Further, in the present invention, as described above, if any one of (A) cationic polymer and (B) polyvinyl alcohol is contained, the contact lens is sterilized by such a component. The agent adsorption site is effectively coated, and the effect of preventing the adhesion of the bactericide to the contact lens is advantageously obtained. More preferably, (A) the cationic polymer and (B) the polyvinyl alcohol. Are preferably used in combination, and by doing so, the contact lens is coated more firmly, and the effect of preventing the disinfectant from adhering to the contact lens is further improved. As described above, when the above (A) cationic polymer and (B) polyvinyl alcohol are used in combination, the content ratio thereof is not particularly limited, but (A) the cationic polymer and (B) the polyvinyl alcohol. The concentration ratio (weight ratio) is desirably used in a ratio of (A) :( B) = 1: 10 to 10: 1. By adopting such a content ratio, the disinfectant is attached or removed. The cationic polymer and polyvinyl alcohol are securely fixed or bonded to the portion of the contact lens that is easily adsorbed, so that the disinfectant can be effectively blocked.

  By the way, in addition to the above-mentioned (A) cationic polymer and (B) polyvinyl alcohol, the contact lens solution according to the present invention does not irritate eyes when wearing a contact lens immersed in the solution. In addition, the osmotic pressure is usually made isotonic for the purpose of adjusting the osmotic pressure within a range substantially equal to the physiological osmotic pressure of about 250 to 400 mOsm / kg so as not to affect the shape of the contact lens. An agent can be included.

  Such isotonic agents are generally ionic tonicity agents such as sodium chloride, potassium chloride, amino acids (such as glycine), non-ionic properties such as sugars, sugar alcohols, polyhydric alcohols or ethers or esters thereof. An isotonizing agent can be mentioned, and any one or more of these conventionally known ones are appropriately selected and used. The above-mentioned (A) cationic polymer and / or (B) polyvinyl Among them, a nonionic tonicity agent is particularly preferably used from the viewpoint of further improving the effect of preventing the disinfectant by alcohol. This is because (A) the cationic polymer and / or (B) polyvinyl alcohol can be adjusted within a range equal to the physiological osmotic pressure without interfering with the fixation or bonding of the polyvinyl alcohol to the contact lens.

  Specific examples of the nonionic tonicity agent may include propylene glycol, glycerin, glycine, sorbitol, etc., and one of these may be used alone or in combination of two or more. it can. And by adding and including such a nonionic tonicity agent, generation | occurrence | production of eye irritation will be suppressed more advantageously, and a further outstanding usability will come to be obtained. Among these, in particular, propylene glycol is more preferably employed because it can be advantageously adjusted within a range equal to the physiological osmotic pressure at a relatively low concentration. And when such a nonionic tonicity agent is added, the addition amount is set so as to be the desired osmotic pressure according to the addition amount of other components, etc. The contact lens solution according to the invention is usually used in a concentration range of 0.1 to 3 w / w%.

  In addition to the isotonic agent, the contact lens solution according to the present invention includes a chelating agent, a pH adjusting agent, a buffering agent, a surface active agent, as long as the antifouling effect of the bactericide according to the present invention is not impaired. Various known additives that have been conventionally added to and contained in liquid agents for contact lenses, such as agents and thickeners, can be appropriately selected and contained. In the contact lens solution according to the present invention, the antibacterial agent that causes eye damage such as corneal epithelial disorder, that is, prevention of adhesion to the contact lens, for the purpose of preventing the antibacterial agent from adhering to the contact lens. Quaternary ammonium germicides such as biguanide germicides such as PHMB (biguanide polymer) and alexidine (biguanide dimer), benzalkonium chloride (quaternary ammonium low molecular weight compounds), etc. Such a disinfectant is not added.

  Here, the chelating agent is blended to prevent metal ions such as calcium from being deposited or adsorbed on the contact lens. For example, ethylenediaminetetraacetic acid (EDTA) and salts thereof such as ethylenediamine Examples thereof include acetic acid · disodium (EDTA · 2Na), ethylenediaminetetraacetic acid · trisodium (EDTA · 3Na), and the like. Such a chelating agent is generally added at a rate of about 0.005 to 0.5 w / w%.

  In addition, the pH adjuster and buffering agent are blended to adjust the pH value of the contact lens solution to near neutral so as not to irritate the eyes, For example, sodium hydroxide, potassium hydroxide, hydrochloric acid and the like can be mentioned, and examples of the buffer include phosphate buffer, borate buffer, carbonate buffer, 2-amino-2-methyl. Good-Buffer such as -1,3-propane (AMP) buffer, tris (hydroxymethyl) aminomethane (Tris) buffer, bis (2-hydroxyethyl) iminotris (hydroxymethyl) methane (Bis-Tris), etc. Can be mentioned.

  Furthermore, the surfactant is blended in order to stably solubilize the water-insoluble component in the aqueous medium or to remove dirt such as eye fat, and the like. Any conventionally known surfactant can be added as long as the prevention effect is not impaired. Among these, nonionic surfactants are particularly suitable. Specific examples include polyglycerin fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene / polyoxypropylene block copolymer, polyoxyethylene / polyoxypropylene ethylenediamine, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkylphenyl ether formaldehyde condensation , Polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl phenyl ether, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene castor oil, polyoxyethylene sterol, polyoxyethylene hydrogenated sterol, polyoxy Ethylene fatty acid ester, polyoxyethylene / polyoxypropylene alkyl ether, poly Examples thereof include xylethylene lanolin alcohol, polyoxyethylene alkylamine, polyoxyethylene alkylamide, polyoxyethylene alkyl ether phosphoric acid, polysorbate and the like. Generally, at a concentration of about 0.001 to 5 w / w%, it is advantageous. Used.

  In addition, the thickener is blended in order to adjust the viscosity of the liquid for contact lenses and improve the feeling of use. For example, various gums such as heteropolysaccharides, synthetic organic High molecular compounds such as poly-N-vinylpyrrolidone, polyethylene glycol, polypropylene glycol, polyacrylamide, and the like, and further cellulose derivatives and starch derivatives can be used as appropriate.

  By the way, in preparing the contact lens solution according to the present invention containing (A) a cationic polymer and / or (B) polyvinyl alcohol as described above, no special method is required, purified water, It can be easily obtained by dissolving each component in an aqueous medium such as distilled water.

  The contact lens solution according to the present invention obtained as described above is used, for example, when packaging a new contact lens, and is shipped from a manufacturer and provided to users (consumers). It is preferably used as a distribution preservation solution (packaging solution) used for immersing new contact lenses, and as a conditioning solution for adjusting the lens state of contact lenses (non-new lenses) after wearing. As a result, the effect of preventing the attachment of the bactericide by the liquid for contact lenses according to the present invention can be exhibited very advantageously. In addition to the above-mentioned distribution preservation solution and conditioning solution, other contact lens care products (for example, contact lenses) as long as they can be brought into contact with the contact lens while being heated to a predetermined temperature, as will be described later. It can also be applied to rinsing liquids, preserving liquids, etc.).

<Distributed stock solution>
When the contact lens solution according to the present invention is used as a distribution preservation solution (packaging solution) as described above, for example, first, at least one new contact lens is used together with the contact lens solution according to the present invention in a blister case. After immersing the entire contact lens in the contact lens solution, covering the opening of the packaging container with a packaging sheet such as a plastic film, Seal fluid tightly. Thereafter, in order to sterilize the new contact lens and solution in the packaging container, the autoclave sterilization treatment (heat treatment) with high-temperature and high-pressure saturated steam is performed on the contact lens package product containing the new contact lens and the solution. ). At this time, since the autoclave sterilization treatment (heat treatment) is generally performed under conditions of about 120 to 125 ° C. and about 10 to 30 minutes, both the liquid agent and the contact lens accommodated in the packaging container are 120 ° C. It will be heated to a certain temperature.

  Thereby, at the same time as the sterilization process is performed, the (A) cationic polymer and / or (B) polyvinyl alcohol is applied to the surface or inside of the contact lens, in particular, a biguanide-type disinfectant such as PHMB or Alexidine, or a benzil chloride It becomes extremely firmly fixed or bonded to a contact lens portion to which a bactericidal agent such as a quaternary ammonium type bactericidal agent such as ruthenium is likely to adhere. As a result, after taking out the contact lens from the sealed contact lens package and wearing it, the contact lens is treated with a CL care (contact lens care) solution (for example, MPS) containing a cationic polymer disinfectant. ) Can effectively prevent or suppress the disinfectant contained in the CL care solution from adhering to the contact lens. Moreover, since the cationic polymer and / or polyvinyl alcohol is firmly fixed or bonded to the contact lens when heat energy is applied, the disinfectant is not as heat-resistant as compared with the lens not applied with heat. The anti-adhesion effect lasts for a long time. That is, even when the contact lens is repeatedly worn and repeatedly immersed in a CL care solution containing a bactericidal agent, the effect of preventing the bactericidal agent from being attached can be obtained many times. For this reason, when the contact lens solution according to the present invention is used as a circulation preservation solution, it is possible to effectively prevent the occurrence of eye damage caused by a bactericidal agent in the initial stage of contact lens use.

  In addition, since the cationic polymer and polyvinyl alcohol firmly fixed to or bonded to the contact lens do not inhibit the bactericidal effect of the bactericidal agent, the contact lens subjected to the above-mentioned immersion / heating treatment is used. Even when immersed in the CL care solution, the bactericidal action of the bactericide in the CL care solution can be sufficiently exerted. In addition, the contact lens that has been dipped and heat-treated using the contact lens solution according to the present invention is coated with a cationic polymer and / or polyvinyl alcohol as described above. In addition, it is possible to enjoy the benefit of preventing adhesion of cationic soil components such as lysozyme protein contained in tears during wearing.

<Conditioning solution>
When the contact lens solution according to the present invention is used as a conditioning solution, for example, firstly, a contact lens after wearing (non-new contact lens) removed from the eye, a CL care solution to which a cleaning component is added, or the present invention. After removing dirt such as protein by rubbing or soaking using a contact lens solution according to the present invention, the cleaned contact lens is housed in a lens case together with the contact lens solution according to the present invention. The entire contact lens is immersed in the contact lens solution. Thereafter, the lens case containing the contact lens and the liquid agent is put in a conventionally known contact lens boiling device (boiling disinfection device) and boiled to be heated to a temperature of about 100 ° C. As a result, the (A) cationic polymer and / or (B) polyvinyl alcohol is extremely firmly fixed or bonded to the surface or inside of the contact lens, particularly to the contact lens portion where the bactericide is easily attached. It becomes like this. As a result, the same effect as in the case of the above-mentioned circulation preservation solution can be obtained.

  By the way, according to the present invention, in order to prevent the disinfectant from adhering, as described above, after the contact lens is immersed in a contact lens solution containing (A) a cationic polymer and / or (B) polyvinyl alcohol, It is only necessary to heat the contact lens solution in the immersed state, but the heating temperature at this time needs to be set to at least 60 ° C., and by adopting such a temperature, The conductive polymer or polyvinyl alcohol is firmly fixed or bonded to the contact lens, and the surface layer portion of the contact lens is coated with the cationic polymer or polyvinyl alcohol.

  When the heating temperature is less than 60 ° C., the cationic polymer or polyvinyl alcohol is difficult to adhere firmly to the contact lens, and even if the surface of the contact lens is coated with the cationic polymer or polyvinyl alcohol, Since the adhesion is not strong, the attached components are easily detached by wearing a contact lens and the effect is not sustained. Moreover, if it is at least 60 ° C. or higher, the antibacterial agent can be prevented from adhering, but in order to obtain a more firmly fixed or bonded state, it is preferably heated to 80 ° C. or higher, more preferably 100 ° C. or higher. In addition, by adopting such a high temperature, it becomes possible to sterilize or disinfect the contact lens at the same time. The upper limit of the heating temperature can be appropriately set according to the material of the contact lens so as not to cause deterioration or deformation of the contact lens, but it is usually desirable that the heating temperature is 150 ° C. or lower.

  In the present invention, the type of contact lens to be subjected to the treatment for preventing the attachment of the bactericide is not limited in any way, for example, non-water content, low water content, high water content, etc. Any of the soft contact lenses and the hard contact lenses classified into all of the above can be targeted, and the material of the contact lenses is not questioned when the contact lens solution according to the present invention is applied. Among them, in the present invention, contact lenses that easily take in biguanide fungicides such as PHMB and Alexidine and quaternary ammonium fungicides such as benzalkonium chloride that cause eye damage, especially soft contacts made of silicone hydrogel. The immersion / heating treatment using the contact lens solution as described above is advantageously performed on the lens. As such silicone hydrogel lenses, Asmofilcon A (Premio, manufactured by Menicon Co., Ltd.), Galyfilcon A (Acuvue Advance, manufactured by Johnson and Johnson Vision Care), Senofilcon A (Accumuation Oasis, Johnson and Johnson Vision Care) Product), Balafilcon A (Pure Vision, manufactured by Bausch & Lomb), and the like.

  Some examples of the present invention will be shown below to clarify the present invention more specifically. However, the present invention is not limited by the description of such examples. Needless to say. In addition to the following examples, the present invention includes various changes and modifications based on the knowledge of those skilled in the art without departing from the spirit of the present invention, in addition to the specific description described above. It should be understood that improvements and the like can be added.

First, a predetermined additive component was added to purified water at various ratios shown in Tables 1 and 2 below, and the osmotic pressure was adjusted to about 290 mOsm / kg and the pH was adjusted to around 7. the contact lens liquid agent according to our case 1 to 24 and Comparative examples 1 to 5, respectively, were prepared.

  In preparing the contact lens solution, the cationic polymer (A) includes polyquaternium-6 (Mercoat 100, manufactured by NALCO, nitrogen content: 11% by weight), polyquaternium-7 (Mercoat 2200, NALCO). Manufactured, nitrogen content: 14% by weight), cationized cellulose polyquaternium-67 (SL-30, manufactured by Amerchol, nitrogen content: 1.0% by weight), cationized chitosan (Kimikachitosan, Kimika Co., Ltd.) Manufactured, Mw: 350,000, nitrogen content: 8.7% by weight), cationized guar gum (Jaguar C17, manufactured by Sanki Co., Ltd., nitrogen content: 1.4% by weight), cationized dextran (CDC-NK, Mewaku Sangyo Co., Ltd., Mw: 1,000,000, nitrogen content: 2.8% by weight), cationized starch (Excel NL, Nippon Star Chemical) Co., Ltd., nitrogen content: 3.0% by weight), polyethyleneimine (Epomin, Nippon Shokubai Co., Ltd., nitrogen content: 31% by weight), phospholipid polymer (LIPIDURE-PMB, manufactured by NOF Corporation) , Nitrogen content: 5.2% by weight), and cationized polyvinyl alcohol (Gosephimer K (K-210), manufactured by Nippon Synthetic Chemical Industry Co., Ltd., degree of saponification: 85.5 to 88.0 mol%, On the other hand, the polyvinyl alcohol of the above (B) has a saponification degree of 99.4 mol% or more and a kinematic viscosity at 20 ° C. and 4 w / w% of 60%. Polyvinyl alcohol (GOHSENOL NH-26, manufactured by Nippon Synthetic Chemical) having a viscosity of ˜68 mPa · s was prepared. Moreover, propylene glycol, glycerin, glycine and sorbitol, which are nonionic tonicity agents, were prepared as isotonic agents. Furthermore, for comparison, a polyvinyl pyrrolidone as a hydrophilic polymer, carboxymethyl cellulose (CMC) as a thickener, and poloxamer 407 as a nonionic surfactant were prepared.

On the other hand, as a test contact lens, made of adhesion fungicides easily material (silicone hydrogel), new contact lens (Premio, Ltd. Menicon) was prepared, by the evaluation method described below, experimental examples 1 to 24 and Comparative Examples 1 to 5 were used to evaluate the effect of preventing the disinfectant from adhering to the contact lens by each contact lens solution.

<Evaluation method of fungicide adsorption rate>
(1) The test contact lens is immersed in physiological saline for one night or more to replace it.
(2) substituted contact lens in saline, immersing the contact lens liquid agent prepared as described above (experimental examples 1 to 24, Comparative Examples 1 to 5).
(3) Then, for experimental Examples 1 to 22 and Comparative Examples 1 to 3, was subjected to autoclave treatment (121 ° C. × 20 minutes), it is immersed in room temperature three nights or liquid formulation for contact lenses. As for the experimental examples 22 and 23, after the heat treatment (80 ° C. × 20 minutes), it is immersed in room temperature three nights or liquid formulation for contact lenses. Further, Comparative Examples 4 and 5 are not subjected to any heat treatment, and are immersed in a contact lens solution for 3 nights or more at room temperature.
(4) Next, the contact lens is immersed in a bactericide aqueous solution containing 0.01 w / w% PHMB for about 16 hours.
(5) After that, the contact lens is placed in a staining solution (0.06 w / v% Eosin Y aqueous solution: 2.5 ml, 4 w / v% sodium acetate aqueous solution: 1.0 ml, water: 3.5 ml mixed solution). Dip for 30 seconds.
(6) The contact lens soaked in the staining solution is soaked in 7 mL of ethanol for about 30 seconds to remove excess Eosin Y.
(7) Next, the absorption spectrum of the contact lens is measured under the following conditions using a spectrophotometer.
Analysis conditions Measurement mode: ABS.
Measurement wavelength region: 450-600 nm
Slit width: 8nm
(8) The absorbance (X) at the maximum absorption wavelength (λmax: around 531 nm) of the obtained absorption spectrum is determined. At this time, as the contact lens to which more PHMB is attached, the absorbance (X) shows a larger value.
(9) The above-mentioned operations (1) and (5) to (8) are carried out in the same manner. After immersing in physiological saline, the absorption spectrum of the contact lens immersed in the dyeing solution without immersing in the bactericidal solution. (Y in FIG. 1) is measured, and the absorbance (Y) at the maximum absorption wavelength is obtained. Further, the above-mentioned operations (1) and (4) to (8) are carried out in the same manner. After immersion in physiological saline, the absorption spectrum of a contact lens immersed in a bactericidal solution and dyed with a staining solution (FIG. 1). Z) is measured, and the absorbance (Z) at the maximum absorption wavelength is determined.
(10) Then, using each of the obtained absorbances (X to Z), the bactericide adsorption rate of each contact lens solution is calculated by the following formula. In addition, it shows that adhesion of PHMB can be prevented, so that the value of PHMB adsorption rate is small, and it was immersed in the physiological saline conventionally used as a distribution preservation | save liquid so that it may be clear also from a following formula. When the contact lens is immersed in a disinfectant solution containing PHMB, the PHMB adsorption rate becomes 100% (∵X = Z), and the contact lens is smaller than 100% compared to the physiological saline. It shows that the antifouling property of the bactericide is high.
PHMB adsorption rate [%] = (XY) / (ZY) × 100

And the adsorption rate (%) of the calculated disinfectant (PHMB) was shown together in the following Table 1 and Table 2. Also, of the absorption spectrum obtained by the above evaluation method, cationized cellulose heat treated contact lenses at 121 ° C. with a solution containing (polyquaternium -67) (Experiment Example 3), saponification degree 99. at 121 ° C. heat treated contact lenses (experiment example 13), and a degree of saponification of cationized cellulose (polyquaternium -67) is 99.4 mol% or more with a liquid formulation containing 4 is mol% PVA although immersed in liquid containing 121 ° C. in heat-treated contact lenses (experiment example 20) and cationized cellulose (polyquaternium -67) using a liquid containing a PVA, it has been subjected heat treatment Nanito FIG. 1 shows the absorption spectrum of the contact lens (Comparative Example 4) not shown in FIG. It indicated.

As is clear from the results of Tables 1 and 2 and FIG. 1, the temperature is 80 ° C. or higher in the state of being immersed in the liquid for contact lenses containing (A) a cationic polymer and / or (B) polyvinyl alcohol. contact lens according to experimental examples 1 to 24, which is heated, the polyvinyl pyrrolidone and carboxymethyl cellulose, in a state of being immersed in the liquid preparation for contact lenses containing other polymers such as poloxamer 407, comparison heated to 121 ° C. Compared with the contact lenses according to Examples 1 to 3, it can be seen that the adsorption rate of the bactericide on the contact lenses is greatly reduced.

In Comparative Example only the presence or absence of heat treatment is different experimental examples 3 and 23 4, and Comparative Examples 5 and Experimental Examples 13 and 24, when respectively compared, by heat treatment, adsorption of fungicides to a contact lens It can be seen that the rate is greatly reduced. Moreover, when heating temperature is compared, it turns out that the one with higher heating temperature (121 degreeC) has the low adsorption rate of the disinfectant.

Furthermore, experimental examples a combination of a plurality of cationic polymers 15-17, and experimental examples 18 to 22 which is a combination of a cationic polymer and polyvinyl alcohol, as compared to that with cationic polymers or polyvinyl alcohol alone The adsorption rate of the bactericide on the contact lens is low. In particular, in the experimental example 20 which combines cationized cellulose and polyvinyl alcohol, the adsorption rate of the sterilant and only 5% is observed that fungicides contact lens is hardly adhered.

It is a graph showing the absorption spectrum of the contact lens measured in the Example.

Claims (9)

Under a state in which by immersing the contact lens, a contact lens solutions used are heated to at least 60 ° C. above the temperature, (A) have a group having a nitrogen atom as a cationic group in a molecule and a nitrogen content contact, characterized in that 99.4 mol% or more of polyvinyl alcohol, contains as fungicides antiadherent: There 0.1-40 wt% der Ru cationic polymer and / or (B) degree of saponification Lens solution. The contact lens solution according to claim 1, wherein the group having a nitrogen atom of the cationic polymer is a quaternary ammonium group. The cationic polymer, cationized cellulose, cationized polyvinyl pyrrolidone, cationic starch, liquid formulation for contact lenses according to claim 1 or claim 2 selected from the group consisting of cationic dextran and Polyquaternium. The contact lens solution according to any one of claims 1 to 3, further comprising a nonionic tonicity agent, and having an osmotic pressure adjusted to 250 to 400 mOsm / kg. The contact lens solution according to claim 4, wherein the nonionic tonicity agent is propylene glycol. The contact lens solution according to any one of claims 1 to 5 , which is a circulating storage solution used when packaging a new contact lens. In the state immersed in the liquid agent for contact lenses of any one of Claims 1 thru | or 6 , the said disinfectant | attachment antibacterial agent is made to adhere by heating to the temperature of 60 degreeC or more at least. A contact lens characterized by that. The contact lens is immersed in the contact lens solution according to any one of claims 1 to 6 , and then heated to a temperature of at least 60 ° C, whereby the antibacterial agent is prevented from adhering to the contact lens. A method for preventing the attachment of a bactericide to a contact lens, wherein The method according to claim 8 , wherein the bactericide is a biguanide and / or quaternary ammonium bactericide.

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