JP3161869B2 - Water-in-oil aerosol composition and process for producing the same - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

FIELD OF THE INVENTION The present invention relates to a water-in-oil aerosol composition and a method for producing the same. More specifically, it has excellent storage stability and affinity for skin and hair, gives a refreshing feeling of use, for example, cosmetics, quasi-drugs, and a water-in-oil aerosol composition that can be suitably used for pharmaceuticals, And a method for easily producing the composition without requiring complicated production steps.

[0002]

2. Description of the Related Art Heretofore, it has been known that a water-in-oil type aerosol composition is excellent as an aerosol composition used for, for example, a cream for skin and hair, in terms of protection of skin and hair. .

[0003] However, in order to prepare a stock solution of the water-in-oil aerosol composition, it is necessary to heat each component and to stir it with, for example, a homomixer, so that the operation is very complicated. . In addition, even if the formulation and manufacturing conditions are sufficiently designed, during mass production, the resulting stock solution of the water-in-oil aerosol composition varies, making management difficult or If the water content is increased to reduce stickiness during use, there is a problem that the viscosity of the stock solution increases, emulsifying properties deteriorate, and layer separation easily occurs.

[0004]

The inventors of the present invention have conducted intensive studies in view of the above-mentioned prior art, and as a result, have found that a specific surfactant is blended in at least one of oils having a specific blending ratio. In the case of using an undiluted solution obtained by mixing the component and the water component, a water-in-oil aerosol composition that has excellent storage stability and affinity for skin and hair and gives a refreshing feeling of use is used. They have found that they can be easily obtained, and have completed the present invention.

[0005]

That is, the present invention provides:
From hydrocarbons, vegetable oils, animal oils and fatty acid esters
5 to 40 % by weight of at least one selected oil component, poly
Glycerin fatty acid ester, decaglycerin fatty acid ester
Ter, diglycerin fatty acid esters and monoglycerides
At least one non-ionic surfactant 0.05 to 10 wt% and water component selected from emissions fatty acid ester 5
Stock solution containing 0 to 90 % by weight 50 to 97% by weight
And a liquefied gas in an amount of 3 to 50% by weight, and 5 to 40 % by weight based on the stock solution.
Hydrocarbons, vegetable oils, animal oils and fatty acid esters
At least one oil component selected from the group consisting of 0.05 to 1
0% by weight of polyglycerin fatty acid ester, decaglycer
Phosphoric acid fatty acid esters, diglycerin fatty acid esters and
And monoglycerin fatty acid esters
It is also necessary to prepare a stock solution by mixing one kind of nonionic surfactant and 50 to 90 % by weight of a water component, and to mix 50 to 97% by weight of the stock solution with 3 to 50% by weight of a liquefied gas. 5 to 40 % by weight of hydrocarbons, vegetable oils, animal oils, etc.
At least one oil component selected from fatty acids and fatty acid esters , 50 to 90 % by weight of a water component, and 0.05 to 10% by weight of polyglycerin fatty acid ester, decaglycerin
Fatty acid esters, diglycerin fatty acid esters and
At least one selected from noglycerin fatty acid esters
A stock solution is prepared by mixing with a kind of nonionic surfactant,
The present invention relates to a method for producing a water-in-oil aerosol composition, which comprises mixing 50 to 97% by weight of the stock solution and 3 to 50% by weight of a liquefied gas.

[0006]

Operation and Examples As described above, the water-in-oil aerosol composition of the present invention contains hydrocarbons, vegetable oils, animal oils and the like.
5 to 40 % by weight of at least one oil component selected from fatty acids and fatty acid esters;
Caglycerin fatty acid ester, diglycerin fatty acid ester
Selected from ter and monoglycerin fatty acid esters
At least one nonionic surfactant 0.05 to 10
It comprises 50 to 97% by weight of a stock solution containing 50% to 90 % by weight and a water component, and 3 to 50% by weight of a liquefied gas.

[0007] The oil component used in the stock solution is a component for imparting permeability and gloss to the skin and hair, and for protecting and maintaining its healthy condition and improving spreadability .
All SANYO which can be used for such purposes, presents a liquid at room temperature, der Ru coal hydrocarbons such as for human, Ru least 1 Tanedea selected from vegetable oils, animal oils and fatty acid esters.

[0008] Specific examples of the oil component, liquidity paraffin, for example Isopar A, Isopar C, Isopar D, Isopar E, Isopar G, Isopar H, Isopar K, Isopar L, Isopar M (manufactured by Exxon) Hydrocarbons such as isoparaffinic hydrocarbons, petrolatum, squalane, α-olefin oligomers, squalene; olive oil, almond oil, jojoba oil, peanut oil, castor oil, coconut oil, palm oil, safflower oil, sunflower oil, Cottonseed oil, avocado oil, camellia oil,
Corn oil, wheat germ oil, rice bran oil, cocoa butter,
Vegetable oils such as sesame oil, evening primrose oil, safflower oil, sasanqua oil, soybean oil, rapeseed oil; animal oils such as lanolin, lanolin derivatives, turtle oil, mink oil, beeswax, pristane, egg yolk oil; butyl stearate, hexyl laurate, isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, diisopropyl adipate, fatty acid ester le as diisopropyl sebacate
There Agerare, it may be used alone or in admixture of two or more thereof.

The mixing ratio of the oil component to the stock solution is 5 to 4
0% by weight. When the blending ratio of the oil component is less than 5 % by weight, the obtained water-in-oil aerosol composition becomes poor in elongation, and when it exceeds 40 % by weight, the water-in-oil The aerosol composition becomes sticky.

The nonionic surfactant used in the stock solution is a component that acts as an emulsifier for obtaining a water-in-oil aerosol composition.

[0011] The nonionic surfactants are, Po Li glycerin fatty acid ester, decaglycerin fatty acid esters,
A diglycerol fatty acid esters and monoglycerol fatty acid esters, they Ru can be used alone or in admixture of two or more. These are, even when many compounding ratio of the water component to be described later to reduce the stickiness of the resulting water-in-oil aerosol composition, emulsifying power hardly decreases.

The mixing ratio of the nonionic surfactant to the stock solution is 0.05 to 10% by weight, preferably 0.1 to 7% by weight. When the mixing ratio of the nonionic surfactant is less than 0.05% by weight, the emulsifying power becomes insufficient, phase separation occurs, and the desired water-in-oil aerosol composition cannot be obtained. When the content exceeds 10% by weight, the tackiness of the surfactant itself increases, and the water-in-oil aerosol composition becomes tacky.

The water component used in the undiluted solution is a component for giving the obtained water-in-oil aerosol composition a refreshing feeling of use. Such a water component is not particularly limited, and is usually used in the form of an aerosol. Purified water such as distilled water and ion-exchanged water used for the composition can be used.

The mixing ratio of the water component to the stock solution is 50 to
90 % by weight. When the mixing ratio of the water component is less than 50% by weight, the refreshing feeling of use of the obtained water-in-oil aerosol composition is reduced,
If it exceeds 90 % by weight, the amount of other components such as the oil component and the nonionic surfactant is reduced, and the desired water-in-oil aerosol composition cannot be obtained. .

The stock solution used in the present invention is prepared by mixing an oil component, a nonionic surfactant and a water component whose desired amounts are adjusted within the above ranges.

In the present invention, in preparing such a stock solution, a nonionic surfactant is added to only one of the oil component and the water component, and then the oil component and the water component are mixed. Alternatively, the oil component and the water component may be mixed after being mixed with both the oil component and the water component.

The stock solution used in the present invention contains an oil component, a nonionic surfactant and a water component as described above. In addition to these, for example, indomethacin, bufexamak, ketoprofen , Dexamethasone, sulfur, tolnaftate, silica microbeads, lipophilic powders such as powders obtained by silicone treatment of zinc oxide and the like; monohydric alcohols such as ethanol and isopropanol, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, glycerin , Alcohols such as polyhydric alcohols such as 1,3-butylene glycol; acetic acid-d
l-α-tocopherol, azulene, l-menthol,
pharmacologically active substances such as dl-camphor; active ingredients;
Preservatives such as parabenzoic acid esters such as methylparaben; antioxidants such as dibutylhydroxytoluene; ultraviolet absorbers such as octyl paradimethylaminobenzoate and octyl methoxycinnamate; cosmetics, quasi-drugs, pharmaceuticals, etc. Can be appropriately selected and blended depending on the use within a range that does not impair the purpose of the present invention. These components may be mixed with either one of the oil component or the water component, or with both components when preparing the stock solution, and are not particularly limited.

In the present invention, the lipophilic powder is added in an amount of 30% by weight or less based on the stock solution, since the water-in-oil type aerosol composition is further improved in dispersibility and hardly causes aggregation. In particular, it is preferable to mix in the range of 1 to 15% by weight. When the mixing ratio of the lipophilic powder exceeds 30% by weight, there is a tendency that when the obtained water-in-oil type aerosol composition is used as an aerosol product, clogging may occur with a valve or the like. is there.

The liquefied gas used as a propellant in the present invention includes, for example, liquefied petroleum gas mainly containing propane, i-butane and n-butane, dimethyl ether,
Hydrofluorocarbons such as difluoromonochloroethane, monochlorodifluoromethane, tetrafluoroethane and the like can be mentioned, and these can be used alone or as a mixture of two or more kinds. Liquefied petroleum gas is preferred in that a water-in-oil aerosol composition can be easily obtained.

The water-in-oil aerosol composition of the present invention is obtained by mixing the stock solution and the liquefied gas and shaking lightly.

The mixing ratio of the stock solution and the liquefied gas is as follows:
It is 50-97% by weight, preferably 60-95% by weight, ie 3-50% by weight of liquefied gas, preferably 5-40% by weight. When the mixing ratio of the stock solution is less than 50% by weight, that is, when the mixing ratio of the liquefied gas exceeds 50% by weight, when the obtained water-in-oil type aerosol composition is sprayed, scattering becomes remarkable, When the amount of the composition adhering to the propellant becomes small and the compounding ratio of the stock solution exceeds 97% by weight, that is, when the compounding ratio of the liquefied gas is less than 3% by weight, the jetting power becomes small , It is difficult to perform the function as an aerosol composition.

The water-in-oil aerosol composition thus obtained is filled into a pressure-resistant container for aerosol by a usual method, and an aerosol valve can be obtained to obtain an aerosol product.

The pressure-resistant container for aerosol is not particularly limited, and a commonly used container can be used.
When filling the water-in-oil type aerosol composition into the pressure-resistant container for aerosol, the internal pressure of the product is usually 8 k at 35 ° C.
g / cm ² · G or less, especially 7 kg / cm ² · G or less, is preferable from the viewpoint of safety.

In the present invention, as described above, a nonionic surfactant is blended with one or both of the oil component and the water component, and the oil component and the water component are mixed. The water-in-oil aerosol composition can be manufactured by mixing the undiluted solution and the liquefied gas, and the composition can be filled in a pressure-resistant container for aerosol. The components are separately charged to form a stock solution, and then the liquefied gas is charged into the pressure-resistant container for aerosol, and the contents are shaken and mixed to form a water-in-oil aerosol composition in the pressure-resistant container for aerosol. Can also be manufactured.

The form of injection of the water-in-oil aerosol composition is not particularly limited, and examples thereof include mist, foam, stream, droplet, and paste.

The production method of the present invention is a method capable of easily producing an aerosol composition without requiring complicated steps,
The aerosol composition obtained by the production method is a water-in-oil type, and has excellent storage stability without phase separation.
In addition, it is less irritating to the skin and hair, has excellent affinity, and gives a fresh feeling without stickiness, so that it can be suitably used for cosmetics, quasi-drugs, pharmaceuticals, and the like.

Next, the water-in-oil aerosol composition of the present invention and the production method thereof will be described in more detail with reference to Examples, but the present invention is not limited to only these Examples.

Example 1 The oil component (A) and the water component (B) shown in Table 1 were separately charged into an aerosol pressure-resistant container (full filling amount: 160 ml), mixed, and then used as a propellant in Table 1. Liquefied gas shown in (C)
, And the mixture was fitted with an aerosol valve and mixed with gentle shaking to obtain an aerosol product filled with a water-in-oil aerosol composition as a soft pomade.

The internal pressure at this time was 4 kg / 35 ° C.
cm ² · G.

[0030]

[Table 1]

The storage stability of the obtained water-in-oil aerosol composition was determined by comparing the state of the composition sprayed immediately after preparation with the composition at room temperature by 1%.
After being left for a month, the state of the composition sprayed was visually observed and examined, and evaluated based on the following evaluation criteria. Table 6 shows the results.

(Evaluation Criteria) A: Even after standing for one month, it can be jetted uniformly, and there is no change in the state of the jetted water-in-oil aerosol composition. B: After standing for one month, phase separation occurs in the jetted water-in-oil aerosol composition. C: After standing for one month, the jetted water-in-oil aerosol composition is completely phase-separated.

Next, 3 g of the water-in-oil type aerosol composition was sprayed on the hair, and the hair was adjusted.
The part where the water-in-oil aerosol composition was jetted could clean hair more clearly than the part where it was not jetted, and it was found that the water-in-oil aerosol composition exhibited a hair-styling effect.

The characteristics of the obtained water-in-oil type aerosol composition were as follows: the characteristics of familiarity with the hair, stickiness and irritation to the skin were measured by randomly extracting the head (hair) of 50 male panelists. 3 g of the water-based aerosol composition was sprayed and examined, and each was evaluated based on the following evaluation criteria. Table 6 shows the results.

(Evaluation Criteria) (a) Familiarity with the Hair A: More than 40 people felt that the familiarity was good. B: 30-39 people felt familiar. C: 20-29 people felt familiar. D: 10 to 19 people felt familiar. E: Only 9 or less felt familiar.

(B) Stickiness A: 9 or less felt that there was stickiness. B: 10 to 19 people felt sticky. C: 20 to 29 people felt sticky. D: 30 to 39 people felt sticky. E: More than 40 people felt sticky.

(C) Skin irritation A: 9 or less felt irritation to the skin. B: 10 to 19 people felt irritation to the skin. C: 20 to 29 persons felt irritation to the skin. D: 30 to 39 people felt irritation to the skin. E: More than 40 people felt irritation to the skin.

Example 2 The oil component (A) and water component (B) used in Example 1 were used.
An aerosol product filled with a water-in-oil aerosol composition as an ultraviolet cut cream was obtained in the same manner as in Example 1 except that the liquefied gas (C) was changed as shown in Table 2.

[0039]

[Table 2]

The storage stability of the obtained water-in-oil aerosol composition was examined in the same manner as in Example 1. Table 6 shows the results.
Shown in

Next, 2 g of the water-in-oil aerosol composition was sprayed on one cheek, and after spending 3 hours outdoors in fine weather, the effect of blocking ultraviolet rays was examined. The cheeks you didn't do are red,
The jetted cheek did not change at all, indicating that the water-in-oil aerosol composition exhibited an ultraviolet blocking effect.

As for the characteristics of the water-in-oil aerosol composition, 2 g of the water-in-oil aerosol composition was randomly applied to the cheeks of 50 female panelists regarding skin familiarity, stickiness and skin irritation. Inspection was carried out, and each was evaluated in the same manner as in the evaluation criteria used in Example 1.
(Similar to the evaluation criteria for familiarity with hair)). Table 6 shows the results.

Example 3 The oil component (A) and water component (B) used in Example 1 were used.
An aerosol product filled with a water-in-oil aerosol composition as a skin disease agent (anti-inflammatory) was obtained in the same manner as in Example 1 except that the liquefied gas (C) was changed as shown in Table 3.

[0044]

[Table 3]

The storage stability of the obtained water-in-oil aerosol composition was examined in the same manner as in Example 1. Table 6 shows the results.
Shown in

Next, 3 g of the water-in-oil aerosol composition was sprayed onto the inflamed portion of the upper arm to examine the anti-inflammatory effect. The inflammation was almost alleviated, and the water-in-oil aerosol composition exhibited the anti-inflammatory effect. I understand.

Further, the characteristics of the water-in-oil aerosol composition were examined in the same manner as in Example 2 (however, sprayed on the upper arms of panelists of 50 men and women randomly selected) and evaluated. Table 6 shows the results.

Example 4 The oil component (A) and water component (B) used in Example 1 were used.
An aerosol product filled with a water-in-oil aerosol composition as a night cream was obtained in the same manner as in Example 1 except that the liquefied gas (C) was changed as shown in Table 4.

[0049]

[Table 4]

The storage stability of the obtained water-in-oil aerosol composition was examined in the same manner as in Example 1. Table 6 shows the results.
Shown in

Next, 2 g of the water-in-oil aerosol composition was sprayed on one cheek, and after going to bed overnight, the moisturizing (moisturizing) effect was examined. The water-in-oil aerosol composition was sprayed. The cheek was more moist and moist than the cheek that was not sprayed, indicating that the water-in-oil aerosol composition exhibited a moisturizing (moisturizing) effect.

The properties of the water-in-oil aerosol composition were examined and evaluated in the same manner as in Example 2. Table 6 shows the results.
Shown in

Example 5 The oil component (A) and the water component (B) used in Example 1 were used.
An aerosol product filled with a water-in-oil aerosol composition as an athlete's foot was obtained in the same manner as in Example 1 except that the liquefied gas (C) was changed as shown in Table 5.

[0054]

[Table 5]

The storage stability of the obtained water-in-oil aerosol composition was examined in the same manner as in Example 1. Table 6 shows the results.
Shown in

Next, 1 g of the water-in-oil aerosol composition was sprayed onto the athlete's foot on the toes for 2 weeks to examine the healing effect. The athlete's foot was almost cured, and the water-in-oil aerosol composition was obtained. It was found that it exhibited a healing effect of athlete's foot.

The characteristics of the water-in-oil type aerosol composition were examined in the same manner as in Example 2 (however, sprayed on the toes of 50 male panelists randomly selected) and evaluated. Table 6 shows the results.

The components shown in Tables 1 to 5 are as shown below.

Liquid paraffin high coal K-140, diglyceryl monooleate NIKKOL DGMO-C manufactured by Kaneda Corporation, decaglyceryl pentaoleate NIKKOL Decaglyn 5-0 manufactured by Nikko Chemicals Co., Ltd., diglyceryl manufactured by Nikko Chemicals Co., Ltd. Dioleate NIKKOL DGMO, Nikko Chemicals Co., Ltd. Diglyceryl monostearate NIKKOL DGMS, Nikko Chemicals Co., Ltd.

[0060]

[Table 6]

From the results shown in Table 6, the water-in-oil aerosol compositions obtained in Examples 1 to 5 did not undergo phase separation even after long-term storage, and had good compatibility. It can be seen that it was excellent without sticky feeling and irritation to the skin.

[0062]

The production method of the present invention is a method capable of easily producing an aerosol composition without requiring complicated steps, and the water-in-oil type aerosol composition obtained by the production method has no phase separation. It is excellent in storage stability, has little affinity for skin and hair, has good affinity, and gives a fresh feeling without stickiness, so it is suitable for use in cosmetics, quasi-drugs, pharmaceuticals, etc. Can be.

Continuation of the front page (58) Field surveyed (Int. Cl. ⁷ , DB name) A61K 9/12 A61K 47/00-47/48 A61K 7/00

Claims (9)

(57) [Claims] 1. Hydrocarbons, vegetable oils, animal oils and fats
At least one oil component selected from acid esters 5 to 4
0 % by weight, polyglycerin fatty acid ester, decaglycer
Phosphoric acid fatty acid esters, diglycerin fatty acid esters and
And monoglycerin fatty acid esters
Is also one nonionic surfactant in an amount of 0.05 to 10% by weight .
Undiluted solution 50 containing 50 to 90 % by weight of water component
A water-in-oil aerosol composition comprising about 97% by weight and 3-50% by weight of a liquefied gas. 2. A liquefied gas is liquefied petroleum gas claim 1
Serial water-in-oil aerosol composition of the mounting. 3. A stock solution is a water-in-oil aerosol composition of 2 claim 1 or those containing 1 to 15 wt% lipophilic powder. 4. An undiluted solution of 50 to 70% by weight and a liquefied gas of 30 to
The oil according to claim 1, 2 or 3, comprising 50% by weight.
Water type aerosol composition. 5. Hydrocarbon of 5 to 40 % by weight with respect to the stock solution
Selected from bases, vegetable oils, animal oils and fatty acid esters
At least one oil component and 0.05 to 10% by weight
Polyglycerin fatty acid ester, decaglycerin fat
Acid ester, diglycerin fatty acid ester and monog
A stock solution is prepared by mixing at least one nonionic surfactant selected from lyserine fatty acid esters and 50 to 90 % by weight of a water component, and 50 to 97% by weight of the stock solution is mixed with a liquefied gas. A method for producing a water-in-oil aerosol composition, comprising mixing 3 to 50% by weight. 6. An undiluted solution of 50 to 70% by weight and a liquefied gas of 30 to
6. A water-in-oil type azo according to claim 5, which is mixed with 50% by weight.
Method for preparing the composition. 7. Hydrocarbon of 5 to 40 % by weight with respect to the stock solution
Selected from bases, vegetable oils, animal oils and fatty acid esters
At least one oil component, 50 to 90 % by weight of water component and 0.05 to 10% by weight of polyglycerin fatty acid ester;
Stele, decaglycerin fatty acid ester, diglycerin
Fatty acid esters and monoglycerin fatty acid esters?
A non-ionic surfactant selected from at least one nonionic surfactant to prepare a stock solution, and mixing 50 to 97% by weight of the stock solution with 3 to 50% by weight of a liquefied gas. A method for producing a water-based aerosol composition. 8. The oil component is mixed with the nonionic surfactant so that the total amount of the nonionic surfactant mixed with the water component is 0.05 to 10% by weight based on the stock solution. A method for producing the water-in-oil aerosol composition according to claim 7. 9. An undiluted solution of 50-70% by weight and a liquefied gas of 30-70%
9. Water-in-oil according to claim 7 or 8, which is mixed with 50% by weight.
A method for preparing aerosol compositions.