JP3140733B2 - Biological magnetic field map display - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method of measuring a magnetic field of a living body, which is suitable for measuring a magnetic field of the living body caused by an electric current in the living body, such as a neural activity of the living brain or a cardiac muscle activity of the heart. About.

[0002]

2. Description of the Related Art The distribution of a weak magnetic field generated from a living body is measured using a superconducting quantum interference device (SQUID), which is a conventional magnetic sensor, and the position of an active current inside the living body is estimated from the measurement result. A multi-channel biomagnetic imaging device for imaging the distribution is known. Such a conventional example is disclosed in, for example, Japanese Patent Application Laid-Open No. Hei 4-3193.
No. 34 or JP-A-5-146416.

[0003]

The above-mentioned prior art relates to the principle of operation of a biomagnetic imaging apparatus, and its disclosure does not disclose any technical problems or means for implementing the present invention. Further, the conventional example relates to a biological activity current generated inside the brain, and does not specifically disclose other parts.

An object of the present invention is to provide a device which can easily display a magnetic field diagram of a living body from the magnetic field intensities at a plurality of measurement positions and has good operability. It is an object of the present invention to provide a biological magnetic field map display device that can perform the above.

[0005]

The present invention is characterized in that a processing function display, analysis data display and operation item display are performed on the same screen for a biomagnetic field diagram. There are other features in the arrangement.

The present invention specifically provides the following devices.

According to the present invention, a biomagnetic field of a subject is set at a plurality of positions.
The living body that measures with the and displays the magnetic field diagram as the processing result
In the magnetic field map display device, processing function items including measurement
Processing function display section and AFA parameter setting display
Operation area display section and the set AFA parameters
Analysis data display section that displays data measured under the following conditions
And display processing functions and operation area on the same screen
And measured under the conditions of the set AFA parameters.
Of the living body performing the display processing of the analysis data display showing the
A magnetic field map display is provided.

[0008] The present invention further relates to the above AFA parameter setting.
The display is a biological magnetic field map display device having an HPF setting display.
I will provide a.

In the present invention, the operation area display section may further include
Including the measurement time setting display for setting the measurement time
A magnetic field map display is provided.

In the present invention, the operation area display section may further include
Biological magnetic field chart with display for setting measurement intervals
An indication device is provided.

In the present invention, the operation area display section may further include
Horizontal time of output display in the analysis data display
It has a scale setting display for setting the scale.
Solutions that display measured data on a set time scale
Provided is an apparatus for displaying a magnetic field map of a living body having an analysis data display section.
I do.

In the present invention, the operation area display section may further include
Includes display of measurement start button to instruct measurement start
An apparatus for displaying a magnetic field map of a living body is provided.

According to the present invention, a biomagnetic field of a subject is set at a plurality of positions.
The living body that measures with the and displays the magnetic field diagram as the processing result
In the magnetic field map display device, processing function items including measurement
Processing function display section and the superconducting quantum interference device at the measurement point
Magnetic field lock setting to set or release magnetic field lock
Operation area display including display and measurement at the above measurement points
Has an analysis data display section for displaying the
In addition, processing function display, operation area display and measurement point on the same screen
Analysis data display showing data measured in
An apparatus for displaying a magnetic field diagram of a living body to be processed is provided.

According to the present invention, the biomagnetic field of the subject is set at a plurality of positions.
The living body that measures with the and displays the magnetic field diagram as the processing result
In the magnetic field diagram display method of
Display the processing function items, and display the AFA parameter on the operation area display.
Displays the meter setting display and is set in the analysis data display section.
The data measured under the conditions of the AFA parameters
And display processing functions and operation areas on the same screen.
And the AFA parameters set in the analysis data display section
Analysis data display showing data measured under the following conditions
A method for displaying a magnetic field diagram of a living body to be processed is provided.

According to the present invention, the operation area display unit may further include a measurement unit.
The living body that displays the measurement time setting display for setting the time
To provide a method for displaying a magnetic field diagram.

According to the present invention, the operation area display unit may further include a measurement unit.
Chart of the biological body to display the display for setting the interval of
Provide a method of indicating.

In the present invention, the operation area display section may further include
Horizontal time of output display in the analysis data display
Biological body displaying scale setting for setting the scale
To provide a method for displaying a magnetic field diagram.

According to the present invention, the operation area display section further includes a
Displays a measurement start button for instructing the start of measurement.
A method for displaying a magnetic field diagram of a body is provided.

The present invention further relates to the AFA parameter setting.
The display is a method of displaying a magnetic field diagram of a living body having an HPF setting display.
I will provide a.

According to the present invention, the biomagnetic field of a subject is
The living body that measures with the and displays the magnetic field diagram as the processing result
In the magnetic field diagram display device of
Display the processing function items, and
Magnetic field lock for setting the magnetic field lock of a conduction quantum interference device
And display the measurement settings in the analysis data display section.
Display measured data and process it on the same screen
Function display, operation area display and measurement at the above measurement points
Living body performing display processing of the analysis data display showing the extracted data
To provide a method for displaying a magnetic field diagram.

According to the present invention, the biomagnetic field of the subject is
The living body that measures with the and displays the magnetic field diagram as the processing result
In the magnetic field map display device, processing function items including measurement
Processing function display section and AFA parameter setting display
Operation area display section and the set AFA parameters
Analysis data display section that displays data measured under the following conditions
And display processing functions and operation area on the same screen
And measured under the conditions of the set AFA parameters.
Display processing of the analysis data display showing the
The work area display shows the magnetic field of the superconducting quantum interference device at the measurement point.
Displays the magnetic field lock setting to set or cancel the lock.
To provide a magnetic field map display of a living body.

[0022]

FIG. 1 shows a schematic configuration of an embodiment of a biomagnetism measuring apparatus according to the present invention. In order to remove the influence of environmental magnetic noise, the biomagnetism measuring device is installed in the magnetic shield room 1. The subject 2, which is a subject composed of a living body, is measured while lying on the bed 3. The body surface of the subject (in the case of the chest, generally parallel to the chest wall) is assumed to be substantially parallel to the surface of the bed 3, and this surface is defined by the xy plane of the rectangular coordinate system (x, y, z). It is assumed that they are parallel. Although the subject's chest is curved and inclined, it is assumed to be substantially parallel for ease of explanation.

Above the chest of the subject 2, a dewar 4 filled with a liquid He as a refrigerant is arranged, and the dewar is made of a superconducting quantum interference device (SQUID = Superconducting Qu).
It contains a plurality of magnetic sensors including an antum interference device and a detection coil connected to the SQUID. The liquid He is continuously replenished from the automatic replenishing device 5 outside the magnetic shield 1.

The output of the magnetic sensor outputs a voltage which has a specific relationship with the strength of the biomagnetic field generated from the subject 2 and which is detected by the detection coil (it can be considered as a magnetic flux density). The signal is input to a FLL (Flux Locked loop) circuit 6. The FLL circuit 6 cancels a change in the biomagnetic field (biomagnetism) input to the SQUID via a feedback coil so as to keep the output of the SQUID constant (this is called a magnetic field lock). By converting the current flowing through the feedback coil into a voltage, a voltage output having a specific relationship with a change in the biomagnetic signal can be obtained. Since the detection is performed via the feedback coil as described above, a weak magnetic field can be detected with high sensitivity. The output voltage is input to an amplifier / filter / amplifier (AFA) 7 whose output is sampled and A / D converted.
The data is taken into the computer 8. The computer 8 is composed of a personal computer, 8-1 is its display unit, 8-2
Indicates a keyboard, and 8-3 indicates a mouse. Mouse 8
Reference numeral -3 is used to select a processing target by moving a cursor on the screen. This operation can also be performed by operating the keyboard. The input gain (I _gain ) and the output gain (O _gain ) of the AFA 7 are adjustable, and the AFA 7 is a low-pass filter (LPF) that passes a frequency signal equal to or lower than the first reference frequency. It includes a high-pass filter (HPF) that passes a frequency signal equal to or higher than the low second reference frequency and a notch filter (BEF) that cuts off the commercial power frequency.
The computer 8 can perform various types of processing, and the processing results can be displayed on the display unit 8-1. Note that the computer 8 shown in FIG. 1 shows one embodiment, and the present invention is not limited to this. For example, a device provided with a display having a touch panel, or a device using another coordinate pointing device, for example, a trackball or a joystick, instead of a mouse may be used. In some cases, the computer may be connected via a public telephone line.

As the SQUID, for example, a DC SQUID is used as an example. When an external magnetic field is applied to the SQUID, a DC bias current ( _Ibias ) is supplied to the SQUID so that a voltage (V) corresponding to the external magnetic field is generated. When the external magnetic field is represented by a magnetic flux Φ, a characteristic curve of V with respect to Φ, that is, a Φ-V characteristic curve is given by a periodic function. Prior to the measurement, an operation is performed to adjust the offset voltage (V _OFF ) of the FLL circuit 6 to make the DC voltage of the Φ-V characteristic curve zero level. Furthermore, A
The offset voltage (A _OFF ) of the AFA 7 is adjusted so that when the input of the FA 7 is zero, the output becomes zero.

When a large magnetic field is applied to the SQUID from the outside, the magnetic field is trapped by the SQUID and its normal operation cannot be performed. In that case, SQUID
Can be heated once to a normal state, and then the heating can be stopped to remove the trapped magnetic field. The heating operation of the SQUID in that case is called a heat flash.

FIG. 2 shows the arrangement of the magnetic sensors. The detection coil of the magnetic sensor includes a coil for detecting a tangential component of the biomagnetic field (a component substantially parallel to the living body plane, that is, the xy plane) and a normal component of the biomagnetic field (a component orthogonal to the living body plane, that is, the xy plane). There is a coil that detects As a coil for detecting a tangential component of a biomagnetic field, the coil surface is in the x direction and y direction.
Two coils, each oriented in the direction, are used,
As the coil for detecting the normal component of the biomagnetic field, a coil whose coil surface faces the z direction is used. A plurality of magnetic sensors 20-1 to 20-8, 21-1 to 21-8, 22-
1-22-8, 23-1-23-8, 241-1-24-
8, 25-1 to 25-8, 26-1 to 26-8 and 27
As illustrated in FIG. 2, -1 to 27-9 are arranged in a matrix on a biological surface, that is, a surface substantially parallel to the xy plane. Although the number of magnetic sensors may be arbitrary, in FIG. 2, the number of magnetic sensors is 8 × 8 = 64 since the matrix of magnetic sensors is composed of 8 rows and 8 columns. As shown in FIG. 2, each magnetic sensor is arranged so that its longitudinal direction coincides with the direction perpendicular to the living body plane, that is, the xy plane (z direction). In this embodiment, the bed surface and the XY surface of the sensor are parallel to each other. However, in order to increase the measurement accuracy, it is better to approach the body, and it is possible to tilt the body. However, since the human body, which is the subject, is constantly moving, if the human body is brought into close contact with the human body, this movement will move the detection unit, and it will be difficult to perform highly accurate detection.

FIG. 3 shows the structure of each magnetic sensor for detecting the normal component Bz of the biomagnetic field. In the figure, a coil made of a superconducting wire (Ni-Ti wire) is arranged so that its coil surface faces the z direction. This coil is composed of a combination of two coils 10 and 11 having opposite directions. The coil 10 closer to the subject 2 is a detection coil, and the coil 11 farther away is a reference coil for detecting external magnetic field noise. You. External magnetic field noise originates from a signal source that is farther than the subject, so that the noise signal is detected by both the detection coil 10 and the reference coil 11. On the other hand, the magnetic field signal from the subject is weak. Therefore, the biomagnetic signal is detected by the detection coil 10, but the reference coil 11 is hardly sensitive to the biomagnetic signal. For this reason, since the detection coil 10 detects the biomagnetic field signal and the external magnetic field noise signal, and the reference coil 11 detects the external magnetic field noise signal, the difference between the signals detected by both coils is used to obtain the S / N ratio. Measurement of a high biomagnetic field becomes possible. These coils are connected to the input coil of the SQUID via the superconducting wire of the mounting board on which the SQUID 12 is mounted, whereby the component Bz in the normal direction of the detected biomagnetic signal is transmitted to the SQUID.

FIG. 4 shows the configuration of each of the magnetic sensors for detecting the tangential components Bx and By of the biomagnetic field. In the figure, a planar coil is used in a sensor for detecting a biomagnetic component in a tangential direction. That is, the detection coil 10 '
And 10 "and reference coils 11 'and 11" comprise planar coils, which are respectively located in first and second planes that are spaced apart in the z-direction.
These coils are SQUID12 'as well as for normal components.
And the input coil of the 12 ″ mounting board. A sensor 13 for detecting the Bx component and a sensor 14 for detecting the By component are affixed to two mutually orthogonal surfaces of the quadrangular prism. A sensor capable of detecting the By component is formed.

The tangent components Bx and By are shown in FIG.
Alternatively, the normal component Bz obtained by the magnetic sensor shown in FIG. 3 may be obtained by partially differentiating x and y with the magnetic sensor shown in FIG. In this case, both the tangential components Bx and By and the normal component Bz can be detected and measured by one magnetic sensor.

FIG. 5 shows the positional relationship between the magnetic sensor and the chest 30 which is the measurement portion of the subject 2. The points shown represent the intersections of the rows and columns on the matrix shown in FIG. 2, that is, the measurement points of the subject 2, that is, the measurement positions. Each of these measurement positions is also called a channel. As you can see from the figure,
In this embodiment, the height direction of the subject 2 is the y direction, and the lateral direction of the subject 2 is the x direction.

FIG. 6 shows the measurement results of the biomagnetic field at the respective measurement positions shown in FIG. This measurement result shows the time-varying biomagnetic field waveform obtained by performing the above-described processing based on the signals detected by the magnetic sensors corresponding to the respective measurement positions for each corresponding channel in the matrix. Things. In this embodiment, since each channel is provided at a position where the magnetic field generated by the heart muscle can be detected, the waveform in FIG. 6 shows a magnetocardiogram waveform. In addition, the waveform obtained by measuring the magnetic field emitted from the heart muscle is called a magnetocardiogram waveform. As shown in FIG. 6, when the measurement data measured for each channel is displayed corresponding to the position for each channel, this is called a grid map display.
FIG. 6 shows the waveform of the measurement result of the magnetocardiogram for a certain healthy person. Here, (a) shows the magnetocardiogram waveform of the tangential component Bx, and (b)
Shows the magnetocardiogram waveform of the tangential component By, and (c) shows the magnetocardiogram waveform of the normal component Bz.

FIG. 7 shows a magnetocardiogram of a tangential component Bx measured for a certain healthy person by focusing on two specific channels. The solid line shows the magnetocardiogram waveform of one channel, and the dotted line shows the magnetocardiogram waveform of another channel. The time zone T ₁ during which the ventricle of the heart is depolarized, that is, the time of each waveform peak in the systolic QRS wave is shown as t _Q , t _R and t _S , respectively. The time period of the T wave, which is the heart repolarization process (diastole), is indicated as T ₂ . When displaying the measured data, in addition to the grid map display, the data of a single channel may be displayed for each row or column,
Data of all channels or a plurality of channels may be displayed in a superimposed manner. The former is called a single waveform display, and the latter is called a superimposed waveform display.

The obtained magnetocardiogram waveform data is subjected to averaging (averaging) processing, an isomagnetic map or a time integral chart is created based on a biomagnetic field, and the results are displayed. be able to. For example, referring to FIG. 7, a predetermined time (t _OFF ) goes back from the time when the rising portion of the QRS wave coincides with the threshold value S _L, and a predetermined time T starts from the time t ₁ when it goes back. number of times data predetermined to between only up to time t ₂ has elapsed ₃ adding is performed. As shown in the figure, a QRS wave exists between t ₁ and t ₂ . This is averaging, and a predetermined time T ₃ is defined as an averaging time, t
_OFF is called an offset time. The magnetocardiogram waveform data may be integrated over a predetermined time range. A map formed by connecting points (channels) having the same time integration value is called an isochronous integration diagram. A map formed by connecting points having the same magnetocardiogram waveform signal value is called an isomagnetic diagram. In addition,
Since each channel is roughly set, it is possible to make a diagram more suitable for diagnosis by drawing the isomagnetic lines by linearly interpolating between the channels by setting the intervals of the isomagnetic lines, that is, the magnetic field strength difference in advance. it can. Referring to the magnetocardiogram waveform shown in FIG. 7, the time from time t ₁ to the peak position of the QRS wave (time t _R ) is called a propagation time, and a map formed by connecting points at which the propagation times are equal is shown. It is called an equal propagation time diagram. Setting the level of the threshold S _L can be changed. t ₁ for the time, which, thresholds rise portion of the QRS wave S _L
Is determined on the basis of the time when the threshold value coincides with the threshold value S _L. The time point t ₁ may be further determined by detecting a peak position time point (t _R time point) of the QRS wave and using this time point as a reference. The measured biomagnetic signal is generated by an electrophysiological phenomenon in a living body, and its source is approximated by a current dipole model. The current dipole of the magnetic field source is synthesized and displayed on the isomagnetic diagram, which is called a magnetic field source display.

A series of operations from registration of a subject to measurement of data of the registered subject and analysis of the measured data are performed on a display screen displayed on the display 8-1. It is performed while watching. Therefore, prior to the description of the series of operations, the layout of the display screen will be described first.

FIG. 8 shows a basic layout of a display screen displayed on the display 8-1 in FIG. The upper part of the display screen is a title bar part 80 arranged in order from the top.
1. Occupied by a menu bar section 802 and a toolbar section 803 in which icons are arranged. Each of the above units can be considered as a display area or area. These arrangements can be used for other processing purposes, such as registering and retrieving subjects,
The display is also commonly displayed on the display screen in the measurement of the magnetic field, the processing for analyzing the measurement data, and the like. This increases ease of use and reduces measurement and processing time.

The center of the display screen is a subject information section 804 arranged in order from left to right, an analysis data section 805 for displaying analysis data such as a diagram and a waveform, and an operation area section 8.
06. The lower part is occupied by a status bar 807, which is arranged on the left side of a message bar part 807-1 for displaying a guide message relating to the next operation and a date and time display part 8 arranged on the right side thereof.
07-2. The message bar 807
-1 and the date and time display 807-2 may be one display area.

On the display screen in this embodiment, a title bar section 801 at which the name of this system is always displayed at the top, a menu bar section 802 for performing basic operations of the system, and a menu bar section 802 Since the toolbar unit 803 capable of frequently used operations is arranged, the user does not need to search the operation area every time the display screen changes, and always knows the currently operating system by looking at the upper part of the display screen. be able to. Moreover, since the upper part of the display screen is the first part to look at, assuming that a person reads a sentence, it is possible to provide basic items in the operation of this system at the top. In a natural way, usability has been improved. In the center of the display screen, an analysis data display section 805, which is a main body of the display screen, is provided in the center to improve the visibility, and on the right side, an operation area specific to the display screen is provided. By providing 806, the display screen and the operation area in the right-hand operation are arranged in the same manner, so that the operation can be performed without discomfort.
Therefore, even if this display screen is adopted as a display screen with a touch panel, the right hand operating the operation area section 806 does not disturb the analysis data display section 805. Similarly, since the subject information unit 804 having only the confirmation function is provided on the left side of the analysis data display unit 805, the operation can be performed while always confirming the patient. In addition, since the left position is the farthest position in the right hand operation, even if adopted for a display screen with a touch panel, it does not affect the visibility of the display.

The analysis data display section 805 and the operation area section 806 are replaced only when the subject list and the data list of the subject are displayed (FIG. 24). When the subject list screen (FIG. 24) is displayed, the subject information section 804 always displays information on the subject on which the cursor is placed in the subject list on the screen. When analysis data such as a diagram or a waveform is displayed in the analysis data section (see FIGS. 25 to 3)
4) The information of the subject from whom the displayed analysis data is obtained is always displayed. Thus, the relationship between the displayed analysis data and the subject from which the analysis data has been obtained can be clearly known. As described above, on the display screen of this system, the subject information section 804 is always displayed at the fixed position (left side) of the display screen, similar to the menu bar section 802. There is no need to search for the subject information area each time it changes, and it can be known by always looking at a predetermined position (left side) on the display screen.

The title bar displays the name of the frame, specifically, the name "Multichannel MCG System" (FIGS. 24 to 34). In the operation area 806, operation elements such as buttons and text boxes are arranged. The menu bar is where you select the operation menu.
The menu consists of “File (F)”, “Edit (E)”, “List (L)”, “Data measurement (Q)”, “Data analysis (A)”, and “Help (H)”. They are arranged in order.

FIG. 9 shows the contents of each operation menu in the menu section on the display screen. The contents of these menus are displayed as pull-down menus by clicking the corresponding menu buttons.
For this reason, when the operation menu is not required, only the keywords for calling the respective menus are compactly displayed in the menu bar section, so that the display area necessary for each work such as the analysis data section and the operation area section is set. Can be set widely. And when you need an operation menu,
By selecting the keywords arranged in accordance with the operation procedure from the menu bar, the keywords can be displayed and operated. At this time, since the keywords are arranged according to an arrangement of characters (from left to right), the operation can be instructed in a natural manner.

A pull-down menu of "File (F)" is a page layout dialog box (not shown).
To open the “Page layout (U)” for setting the page layout, “Preview (V)” for preview before printing, “Print (P)” for data printing, and terminate the Multichannel MCG System. Includes an item "End of magnetocardiography system (X)".

The "edit (E)" pull-down menu includes an item "delete (D)". The measurement data of the subject in the subject list on the subject list screen (FIG. 24) is displayed in the data list on the same screen, but the item "Delete (D)" is displayed in the data list. This is for deleting the data on which the cursor is placed, and the data must be selected in advance. Clicking this menu opens a confirmation dialog box asking if you want to delete it. When the deletion is required, the button "OK" in the dialog box is clicked, and when the user wants to cancel the deletion, the button "Cancel" is clicked. By displaying and operating this confirmation dialog box, it is possible to reduce erroneous operations of deleting measurement data of the subject by mistake.

The "List (L)" pull-down menu includes "Registration (R)", "List (L)", "Delete (D)",
It includes items of “search (S)” and “cancel (X)”.
When the button “Registration (R)” in the pull-down menu is clicked, a subject registration dialog box shown in FIG. 10 is opened. This is used when registering data on the subject. Items that can be registered are the registration date, the subject's ID number up to a predetermined digit, name, date of birth, height, weight, sex, illness And the subject's comment indicating the classification information of the subject. When the "Register" button in the dialog box is clicked, the data entered for registration is registered, and all of the input boxes are cleared so that re-entry is possible, and the "Cancel" button is clicked. If so, all of the input boxes are cleared, and if the button "Exit" is clicked, the subject registration dialog box is closed.

When "List (L)" in the pull-down menu is clicked, a subject list screen (FIG. 24) is displayed. “Delete (D)” in the pull-down menu is for deleting the subject on which the cursor is placed in the subject list on the subject list screen (FIG. 24), and is clicked. Before the deletion, a confirmation dialog box is displayed to confirm whether or not the deletion is the same as when "Delete (D)" in the pull-down menu is clicked. If deletion is required, the dialog box is displayed. A button “OK” is clicked, and a button “Cancel” is clicked to cancel the deletion. When a subject is deleted, all data in the data list for that subject is also deleted.

When "search (S)" in the pull-down menu is clicked, a search dialog box shown in FIG. 11 is displayed. The subject and the data are searched, and only the searched subject and the data are displayed on the subject list screen. The subjects and data to be searched are all subjects and all data. Data is searched for by giving the subject name, registration date, gender, data type, measurement date, diagnosis result, comment, laboratory technician, body position, etc. as keywords. A composite search combining a plurality of the above keywords can be performed. “Release (X)” in the pull-down menu is used to release the display of only the retrieved subjects and data and display all subjects and all data. The pull-down menu of “Data measurement (Q)” is “Adjustment value file (F)”, “Fully automatic adjustment (A)”, “V _OFF adjustment (V)”, “Manual adjustment (M)”, “Adjustment value file” (F) "," measurement panel (P) "," automatic waveform diagnosis (D) ", and" AFA offset adjustment (O) ".

When the "adjustment file (F)" is clicked, a sub pull-down menu containing "open (O)", "overwrite save (S)" and "save as (A)" is displayed. Is done. “Open (O)” in the sub pull-down menu displays the system adjustment screen (FIG. 34), opens the specified adjustment value file, and sets the system adjustment values, ie, I _bias and V _OFF in the system. Used. “Save (S)” is used to open a confirmation dialog box and overwrite the current adjustment value to the currently opened adjustment value file. “Save as (A)” is used to change the name of the current adjustment value data and save it in another adjustment value file.

When "Fully automatic adjustment (A)" is selected from the pull-down menu, the system adjustment screen (FIG. 34)
Is displayed, and the bias current I _bias and the offset voltage V _{OFF of the} FLL circuit 6 are set according to the flow of FIG.
Is automatically adjusted. When "V _OFF adjustment (V)" is selected, a system adjustment screen (FIG. 34) is displayed, and the offset voltage V _OFF of the FLL circuit 6 is automatically adjusted according to the flow of FIG. 23 described later. When "manual adjustment (M)" is selected, a manual adjustment dialog box shown in FIG. 12 is opened. The operator selects the channel using the scroll bar and mouse, to change the bias current I _bias and offset voltage V _OFF.
If there is no problem with the entered value, the value is set by clicking the "OK" button. If the "Cancel" button is clicked, the changes are invalidated and the dialog box is closed.

When the "measurement panel (P)" is clicked, a data measurement screen including a grid map (FIG. 25) is displayed. When "automatic waveform diagnosis (D)" is clicked, an automatic diagnosis dialog box shown in FIG. 13 is opened. The automatic waveform diagnosis is performed by using Φ-V in the display screen of FIG.
Automatically check the amplitude, median and period of the characteristic curve,
When displaying the V characteristic curve or updating the display of the curve being displayed to the latest state, a channel outside the specified range is notified to the operator as an inappropriate state for measurement. If a channel in an inappropriate state for measurement is detected, an error dialog box is opened and an error message is displayed to notify the operator, but the Φ-V characteristic curve of the channel is displayed in a different color to indicate an inappropriate state. May be indicated. When the minimum amplitude value is checked, when the difference between the maximum value and the minimum value in the Φ-V characteristic curve is smaller than the minimum amplitude value, it is determined that the state is inappropriate for measurement. When the median value is specified, it is determined that the case where the absolute value of the average of the maximum value and the minimum value is larger than the specified median value is inappropriate for measurement. When the period is specified, the measurement is not performed when the period of Φ in the Φ-V characteristic curve is out of the range specified by the first text box (lower limit) and the second text box (upper limit). It is assumed that it is in an appropriate state.
To enable automatic diagnosis of the minimum amplitude, median and period, click the check box to the left of each item with the mouse so that the X mark is displayed, and enter the desired value in the corresponding text box. Should be input. The parameters of the automatic diagnosis input in this manner are enabled by pressing the “OK” button, and the dialog box is closed. When the "Cancel" button is pressed, the entered parameters become invalid and the dialog box is closed. "AFA offset adjustment (O)" is AF
When the "AFA offset adjustment (O)" is clicked, the data measurement screen belonging to the single waveform display (FIG. 2) is used when adjusting the offset voltage A _{OFF of} A7.
5) is displayed.

The pull-down menu of “Data analysis (A)” includes “Averaging (A)”, “Single waveform display (W)”, “Overlap waveform display (M)”, “Grid map display (G)”, “Equimagnetic field diagram (B)”, “Time integration diagram (T)”, “Propagation time diagram (P)”, “Magnetic field source display (S)”, “Line mode (L)”, and “Fill mode ( F) ".

When "Averaging (A)" is clicked, the averaging screen (FIG. 27) is displayed. When "Single waveform display (W)" is clicked, a single waveform display character screen (FIG. 2) is displayed.
8) When the “overlap waveform display (M)” is clicked, the overlay waveform display screen (FIG. 29) is displayed. When the “grid map display (G)” is clicked, the grid map display screen (FIG. 30) is displayed. A check mark (x) is displayed on the left side of the menu to indicate that the selection has been made.
Clicking on “Equimagnetic field diagram (B)” displays the isomagnetic diagram screen (FIG. 31), and clicking on “Time integral diagram (T)” displays the isochronous diagram screen (FIG. 32). When the "Propagation time diagram (P)" is clicked, the equal propagation time diagram screen (Fig. 3
3) are displayed, and a check mark (x) is displayed on the left side of the menu to indicate that the selection has been made. Also,
When "magnetic field source display (S)" is clicked, an inverted triangle mark is displayed on the left side of the menu, and when displaying the isomagnetic map, the magnetic field source approximated by the current dipole is superimposed and displayed (not shown). . When the “line mode (L)” is selected on the screen for the isomagnetic diagram, isochronous integration diagram, isopropagation time diagram, and magnetic field source display, the space between the lines is displayed without filling, and the “filling mode (F ) "Is displayed in a state in which the space between lines is filled. A check mark is displayed on the left side of the menu to indicate the current mode.

The "Help (H)" pull-down menu includes "Table of Contents (C)", "Search by Keyword (S)", and "Version Information (A)". Used to search for topics by keyword and to open the version dialog box.

"Examinee registration" is displayed in the toolbar 803.
(808), “Subject list” (809), “Print”
(810), “Preview” (811), “System adjustment” (812), “Data measurement” (813), and “Data analysis” (814) are arranged. Although these are not shown, they are linked to the functions of the menu, and it is possible to select a frequently used item from the items of the pull-down menu. That is,
"Subject registration" (808) is "Registration (R)" of "List (L)", "Subject list" (809) is "List (L)" of "List (L)", “Print” (810) is “Print (P)” of “File (F)”, “Preview” (811) is “Preview (V)” of “File (F)”, and “System adjustment” (812). ) Is “manual adjustment (M)” of “data measurement (Q)”, “data measurement” (813) is “measurement panel (P)” of “data measurement (Q)”, and “data analysis” ( 814) respectively correspond to "grid map display (G)" of "data analysis (A)". As described above, the menu linked to the icon can be selected by simply clicking the icon. Therefore, frequently used operations can be easily performed simply by clicking on the icon adjacent to the analysis data display section. can do. In addition,
The icon may be selected by the user, or may be automatically displayed on the toolbar 803 according to the frequency of use (the number of times).

Next, a series of operations from registration of the subject to measurement of the data of the registered subject and analysis of the measured data, including the adjustment operation of the system, are performed. This will be described with reference to FIGS.

FIG. 16 shows the flow of the entire operation. When the power of the computer 8 is turned on (S-1), the operating system is started up and the program start icon is displayed on the display unit 8-1. Displayed (S-
2). Multichannel MCG System from the icon
Is selected (S-3), the subject list screen shown in FIG. 24 is displayed instead (S-4).

In the system according to this embodiment, a subject list screen shown in FIG. 24 is displayed as an initial screen at the start of the system. The reason for this is that the relationship between the subject and the measurement or analysis data of the subject is extremely important, and the system manages the subject information as keywords in this system. That is, measurement data and analysis data cannot be managed without subject information. For this reason, in this system, on the subject list screen, first, when the subject is registered or registered, the subject is specified. If there is, specify the target data. It is to be noted that a display screen for waiting time at system startup may be provided prior to the subject list screen, and a display screen serving as a table of contents of the system may be provided.

The subject list screen shown in FIG. 24 will be described. The subject information section is occupied on the left side.
The subject list is displayed at the top of the entire right side, and the data list is displayed at the bottom. Items displayed in the subject information section are the same as those described with reference to FIG. The items in the subject list are ID (subject I
D number), name, registration date (date of data registration),
Number of measurements (number of times data was measured), date of birth, age, height, weight, comments (comments about the subject)
And so on. The subject list can be scrolled with a vertical scroll bar, and the items of the subject list can be scrolled with a horizontal (horizontal) scroll bar. The row of the selected subject is highlighted.

The items in the data list relating to the selected subject include the ID, the type of data (raw (raw) data or averaging (averaging)), and the sampling interval (of the signal when the data measurement was performed). Includes sampling intervals (in milliseconds), sampling time (in seconds), classification (disease classification information), Date and Time (date and time when data was measured), comments (comments on data), and the like. The data list can be scrolled with a vertical scroll bar, and the data list items can be scrolled with a horizontal (horizontal) scroll bar. The row of the selected data is highlighted.

According to the subject list screen, one line of information of each subject is displayed on the subject list. As a result, the information of each subject arranged vertically can be clearly separated, so that the discriminability can be improved. For example, it is possible to reduce the erroneous operation of selecting another subject by mistake. it can. The information of each subject can be scrolled by a horizontal (horizontal) scroll bar, and the information of the selected subject is vertically arranged for each item in a vertically long subject information section, so that visibility is improved. Does not impair. in this case,
The visibility may be further improved by allowing the items of the data list of each subject to move back and forth (left and right). Further, by displaying information of each subject on one line, many subjects can be seen at a time, so that the number of times of scrolling with the vertical scroll bar can be reduced. In addition, the data can be displayed in the lower data list by a simple operation of merely placing the cursor on the subject list from which the user wants to select data on the target subject from the subject list and clicking the cursor. Moreover, since the subject list and the data list are arranged vertically, movement of the line of sight can be reduced, so that the relevance can be easily recognized. Also, the size of the data list can be freely changed by a simple operation of moving the cursor to the upper part of the area and dragging, so that the size can be freely set according to the number of data lists. can do.

In step S-5, a desired subject line is selected from the subject list on the subject list screen. In the case of averaging processing described later, a row of raw data in the data list is always selected. Thereafter, the flow is branched into four by the menu (S-
6). According to one of the branches, a submenu “End of magnetocardiography (X)” in the menu of “File (F)” is selected, and in this case, end processing such as closing the window is performed (S-7). ), Whereby the system is shut down (S-8). Thereafter, the power of the computer 18 is turned off (S-9), and all the operations are terminated.

According to the rest of the branches, averaging processing (S-10), data analysis (S-11), and data measurement (S-12) are performed. The averaging process can be executed by selecting a submenu “Averaging (A)” in a menu “Data analysis (A)”. In addition, data analysis includes “single waveform display (W)” in the menu “data analysis (A)”
"Superimposed waveform display (M)", "Grid map display (G)", "Equimagnetic field diagram (B)", "Time integration diagram (T)", "Propagation time diagram (P)", and "Magnetic field source display" (S) "can be executed by selecting any of the submenus. Further, data measurement can be executed by selecting a submenu "measurement panel (P)" of a menu "data measurement (Q)".
After the completion of steps 10, 11 and 12, the flow returns to step S-4. The details of the subject selection in step S-5, the averaging process in step S-10, the data analysis in step S-11, and the data analysis in step S-12 are described below with reference to FIGS. This will be described in more detail.

FIG. 17 shows the flow of subject selection in step S-5 in FIG. In the case of subject selection, the flow is branched into four by menu selection or subject selection. One of the branches is specified by selecting a subject (S-5).
1) This is the case where the subject selection ends. According to another branch, a submenu "Search (S)" of the menu "List (L)" is selected. Thus, the search dialog box shown in FIG. 11 is opened (S-5-2), and the subject search condition is input using this dialog box (S-5-3). As a result, the subject is searched (S-5-4), and based on this, the display contents of the subject list on the subject list screen shown in FIG. 24 are changed (S-5-5). . According to yet another branch, the submenu "Release (X)" of the menu "List (L)" is selected. In this case, the selected subject is returned to the list of all subjects (S-5-6), and the display content of the subject list is changed (S-5-5). According to the remaining one of the branches, the submenu "Registration (R)" of the menu "List (L)" is selected. In this case, the subject registration dialog box shown in FIG. 10 is opened (S-5).
7) The subject information is input (S-5-8). In these steps, the input termination is determined until all the subjects have been entered (S-5-9), and when the entry is completed, the subject list is updated (S-5).
5-5).

In this embodiment, a plurality of input data or operation instructions to be input are displayed by displaying a pull-down menu on the display screen, except for the character input such as the name and address of the subject, and the selection target is displayed. The input operation is performed by pointing the specific target with a mouse from among the above.
As a result, most operations can be performed by mouse operation, so that a comfortable operation environment can be provided to an operator who is unfamiliar with the keyboard, and the input / operation time can be reduced. The plurality of selection targets of the pull-down menu include:
Since the device or the selection target that can be input / operated in the input / operation state is set and displayed in advance, erroneous input / erroneous operation can be reduced. Further, in this embodiment, since the cursor can be put on the input area and the input can be made via the keyboard, the degree of freedom of the input by the operator is secured.
Further, in this embodiment, it is assumed that a character is input using a keyboard. However, a dialog of the keyboard may be displayed at the time of input, and the input may be performed by operating the mouse with a mouse. Further, a handwriting input dialog may be displayed and handwriting input may be performed by operating the mouse. Furthermore, a touch panel may be provided in the display unit, and input / operation may be performed on the screen via a fingertip or an input pen. Thus, the operability of input / operation can be remarkably improved.

FIG. 18 shows a flow of data measurement in step S-12 in FIG. First, a grid map of a magnetocardiogram waveform is displayed as an initial screen as shown in FIG. 25 (S-12-1). In the figure, in the operation area section, channel selection, waveform monitor ON-OF
F, the lock-unlock of the FLL circuit 6, the automatic adjustment of the offset voltage of the AFA 7, and the operation for the heat flash can be respectively performed. Can be set.

The channel is composed of 64 channels of 8 × 8. Click the “select all channels” button or
Alternatively, all channels can be selected by dragging the channel matrix diagonally from end to end. If a channel matrix is selected in units of rows or columns or one of the items (hereinafter referred to as “channel item”) is dragged, a channel can be selected in units of rows or columns. In any case, based on the selected channel item, the magnetocardiogram waveform of the channel related to the item is displayed on the analysis data display section. In the case of selection in units of rows or columns, the display is as shown in FIG. In this case, the selected waveform is enlarged and displayed in full scale on the time axis. That is, when all 64 channels are selected, as shown in FIG. 25, the analysis data display section is divided into upper, lower, left, and right (cells) so that display of all channels is prioritized. In this case, as shown in FIG. 26, the analysis data section is divided into upper and lower parts to form a familiar graph form in which the time axis is left and right, thereby giving a display form in which visibility is prioritized.

As for the monitoring of the waveform, when the "ON" button is pressed, the acquisition of the signal and the updating of the waveform are repeated at a specified time interval, for example, from 0.5 sec to 2 sec. Monitored. When the “OFF” button is pressed, the updating of the waveform is stopped. About FLL,
Click the "Lock" or "Unlock" button,
The magnetic field lock can be performed on the 64 SQUID sensors, and the lock can be released. In this case, if one button is pressed, the state is maintained until the other button is pressed. This avoids an unselected malfunction state.

When the "AFA offset adjustment" button is clicked, the offset voltage is automatically adjusted. Clicking the "heat flash" button opens the heat flash operation dialog box shown in FIG. If a channel is selected with a mouse or an arrow key and the "OK" button is clicked, a heat flash operation is performed for the SQUID of the selected channel. If the "Cancel" button is pressed, the dialog box closes and the process ends.

For the sampling time (measurement time) and interval, click the corresponding text box with an inverted triangle to open a pull-down menu of selectable numerical values, and select a desired number from the pull-down menu. it can.
The selectable numbers are, for example, 1 second for time,
5 sec, 10 sec, 30 sec, 1 min and 2 min, and the intervals are, for example, 0.1 msec, 0.5 msec, 1.0 msec, 2.0 msec,
4.0 msec, 5.0 msec and 10.0 msec. The time may be selected from about 1 second to about 24 hours as needed. “Time” in the “scale” box means a time scale in msec, that is, a horizontal scale, and “signal” means a scale of the A / D converted signal, that is, a vertical scale. As for these, similarly to the selection of the sampling time and interval, a desired numerical value is selected from a pull-down menu opened by clicking a corresponding text box.

The AFA parameters include an input gain Igain, an output gain Ogain, a low-pass filter (LPF) frequency (reference frequency), a notch filter (BEF) frequency,
Includes high-pass filter frequency (reference frequency). Similarly, a desired number or character is selected from a pull-down menu opened by clicking a corresponding text box. The numbers or letters are for Igain, for example 1, 2, 5, 10, 20, 50,
100, 200, 500 and 1000, for Ogain for example 1, 10 and 100, and for LPF for example 30
Hz, 50 Hz, 80 Hz, 100 Hz, 200 Hz, 400 Hz and 1 kHz, Off for BEF, 50 Hz and 60 Hz, and for HPF for example 0.05 Hz, 0.1 Hz and Thru. Note that these may be input from the keyboard instead of the selection.

As the channels, in addition to the 64 channels, for example, an auxiliary channel of 16 channels is prepared, and for example, an electrocardiographic waveform may be obtained in the auxiliary channel. At the bottom of FIG. 25, the waveform of the tenth channel as a reference channel is displayed, which is the electrocardiographic waveform obtained on the tenth channel among the auxiliary channels. The magnetocardiogram waveform generally contains magnetic noise, while the electrocardiogram waveform does not contain such noise. Therefore, by comparing the displayed magnetocardiogram waveform with the electrocardiogram waveform of the reference channel, information as to whether or not the magnetocardiogram waveform contains magnetic noise can be obtained. Of course, the ECG waveform is not an auxiliary channel,
It may be obtained from any of the four channels. Further, other than the electrocardiographic waveform, an electroencephalogram, a blood flow waveform, a blood pressure waveform, or the like may be used. Further, the electrocardiographic waveform of the pregnant woman and the magnetocardiographic waveform of the fetus may be compared. Further, as the reference waveform, not only a reference waveform of one channel but also a reference waveform of a plurality of channels may be displayed. Further, the reference channel may be used to input not only a signal from a living body but also various control signals for maintenance or the like.

Returning to the flow of FIG. 18, step S-1
In 2-2, the monitor channel is selected in the manner described above (S-12-2), and when the lock button of the FLL is pressed, the magnetic fields of all SQUIDs are locked (step S-12-3). In this state, the setting of the sampling time and signal, which are the measurement parameters, and the setting of the AFA parameters are performed (step S-12-4). With respect to the setting, this setting can be omitted from the next time by using the set condition. As a result, it is not necessary to perform the condition setting every time, so that the setting time can be reduced. Note that the setting condition may be recorded by giving a name or the like so that the setting condition can be called.

When the “start” button in the “measurement” box is pressed, the measurement is started, and “measurement in progress” is displayed and a progress bar indicating the progress of the measurement is displayed as shown in FIG. (Step S-12-5). In the progress bar of this embodiment, the bar extends from left to right in the form of a bar graph as the processing progresses.
Since it suffices to know the current processing progress, a pie chart or the like may be used. Further, the progress bar is displayed at a predetermined position on the measurement screen while leaving the measurement screen around.
As a result, the contents of the display screen do not change significantly, and erroneous operations can be reduced.

When the measurement is started, the displayed signal waveform is fixed as it is, and the progress bar is displayed on the fixed display screen. The update of the progress bar is repeated, for example, every second until the set time ends (S-12-6). When the "stop" button in the "measurement" box is pressed, the measurement is stopped. When the measurement is completed, the screen shown in FIG. 26 is displayed, and the waveform is confirmed (S-12-7). Thereafter, the necessity of saving the data is determined (S-12-8). If the data needs to be saved, the menu "File (F)"-"Save (S)"
Is selected, and the signal is saved and added to the data list of the subject (S-12-9). Thereafter, it is determined whether measurement is necessary again, including the case where storage is not required (S-12-10), and the above steps are repeated if necessary, and all the steps of data measurement are ended if unnecessary. In this case, the menu is selected so that the screen display is as shown in FIG. FIG. 26 shows an example in which the channel in the second column is selected as the channel.

In FIG. 26, at the bottom of the analysis data section, there is a scroll bar 262 through which a scroll box 261 moves. The scroll box 261 is movable between the left and right ends of the scroll bar 262, and the width w of the scroll box represents a time scale. The time width between the left and right ends of the scroll bar 262 indicates the measurement time. Therefore, the displayed waveform is an enlarged waveform of a part of the waveform generated during the measurement time corresponding to the time scale w of the scroll box 261. It is. Thus, the operator indicates how long (the width of the scroll box 261) the waveform currently displayed in the analysis data portion is within the measurement time (the width of the scroll bar 262), and the waveform is the measurement time. Since it is possible to visually recognize whether the first half or the second half is indicated, the visibility can be improved. Further, since the position of the scroll box 261 and the waveform of the analysis data section are linked with each other, the cursor is moved while dragging the scroll box 261 to move the display area of the analysis data section for a predetermined time. May be viewed. In this way, the scroll bar 26 can be easily checked for a predetermined time.
2 can be treated as a table of contents and the details of measurement can be confirmed in detail.

FIG. 19 shows the flow of the averaging process in step S-10 in FIG. In the averaging process, in order to remove noise of each data measured in each channel, an addition is performed for each channel and an average value is calculated. The following processing is performed to set a reference time for the averaging processing of each channel, and the averaging processing of each channel is executed.

First, raw data of the designated subject is read (S-10-1). This is performed by selecting a row in which the "data type" in the list data of FIG. 24 is raw data. As a result, the magnetocardiogram waveform of the channel in the first column shown in FIG. 27 is displayed as an initial display (S-10-2). Next, a display channel is selected (S-10-3). FIG. 27 shows an example in which the channel in the second column is selected. Thereafter, the setting channel is designated (S-10-4). This is performed by clicking a text box of “channel” in a box of “averaging condition” in the operation area display section, or by clicking a mouse on an area displaying a waveform of a desired channel. in this case,
Click the triangle button in the text box to increase the channel number, or click the inverted triangle button to decrease the channel number. FIG. 27 shows an example in which the specified channel is the channel in the second column and second row. By this channel designation, a channel serving as a reference time for the averaging process is specified. In specifying this channel, it is preferable to select the channel having the most typical or easy-to-understand waveform. If there is no channel having a good waveform in the selected row or column, it is possible to start over from the step (S-10-3) again.

When one channel of the analysis data display section is specified, a threshold cursor 271 is displayed at the position of the designated channel as shown in FIG. Thereby, the designated channel can be visually confirmed. In FIG. 27, three slider cursors 273 to 275 movable in the left-right direction are displayed at the upper part of the analysis data display unit 805. These are automatically displayed at the same time when the display screen of FIG. 27 is displayed. Is done.

In step S-10-5, the threshold, offset time, and averaging time, which are the averaging conditions, are set by clicking the corresponding text boxes in the box "Averaging condition". Click the triangle button to increase the number, or click the inverted triangle button to decrease the number. The threshold is set by selecting a number representing the threshold in the "Threshold" text box. As a result, the threshold cursor 271 automatically moves to the position corresponding to the numeral. The moving position in that case can be clearly confirmed by the cursor line. The change (selection) of the number indicating the threshold value in the “threshold value” text box and the movement of the threshold value cursor 271 are interlocked with each other.
It can also be set by moving 1. The slider cursor 273 indicates the position (reference time) at which the rising portion of the waveform matches the threshold value set by the slider cursor 271, and the position indicated by the cursor can be clearly confirmed by the cursor line. The slider cursor 273 moves following the reference time position so as to coincide with the reference time position that changes according to the change of the threshold value. When a number representing the offset time is selected in the “Offset” text box and a number representing the averaging time is selected in the “Time” text box, the slider cursor 27 is positioned at the corresponding position.
4 and 275 move. The moving position in that case can be clearly confirmed by the cursor line of those slider cursors. Slider cursors 274 and 27
The movement of 5 is linked to the selection of a number in the “Offset” text box and the “Time” text box.
For this reason, the offset time and the averaging time can be set by moving the slider cursor.

In step S-10-6, it is set whether averaging should be performed automatically or manually as the averaging mode (S-10-7). Then, click the “Setting” button (S-10-
8) An addition process is performed. Click the "Cancel" button to cancel all averaging conditions. As the addition processing, a time t (reference time) exceeding the threshold is searched for in each channel (S-1).
0-9), and then a waveform is displayed around time t (ie, t-50 so that time t is centered on the screen).
The waveform from msec to t + 50msec is displayed.) (S-1
0-10), and it is determined whether cancel is selected in the manual mode (S-10-11),
If cancel is not selected, waveform addition is performed (S-10-12). Steps S-10-9 to S-10-12 are repeated by the number of additions for each channel, and the added data is divided by the number of additions (S-10-13), and the average is calculated. The ending process ends.

As described above, on the display screen of the averaging process shown in FIG. 27, it is possible to input / operate various conditions of the averaging process from both the operation area portion and the analysis data display portion 805. For example, it is possible to provide the operator with various setting methods, such as setting a rough condition in the analysis data section and setting a detailed value in the operation area section, and shorten the time for setting the condition. In particular,
In this embodiment, by specifying a specific channel from a plurality of channels of the analysis data display unit 805 via a cursor, the channel can be used as a reference channel for the averaging process. Is improved. Moreover, by displaying a threshold cursor or a slider cursor near the designated channel, visual recognition is possible. Furthermore, since the input / operation of various conditions of the averaging process can be performed by a threshold cursor or a slider cursor arranged near the channel, the movement of the operator's line of sight is reduced, and visualization is performed in accordance with the waveform display. Since erroneous operations can be reduced, operability can be improved. The setting conditions, for example, the latest setting conditions may be stored and displayed as the next setting conditions, or each setting condition may be stored with a name and stored.

FIG. 20 shows the flow of data analysis in step S-11 in FIG. The data analysis is intended to display various types of waveforms and diagrams to obtain information necessary for diagnosis. By selecting the menu in FIG. 9, various types of waveforms and diagrams can be selectively displayed. Can be displayed. That is, if "single waveform display (W)" of "data analysis (A)" is selected, the single waveform screen shown in FIG. 28 is displayed (S-11-2), and "data analysis (A)" is displayed. Is selected, the superimposed waveform screen shown in FIG. 29 is displayed (S-11-3), and "grid map display (G)" of "data analysis (A)" is selected. For example, the grid map waveform screen shown in FIG.
-4), if "Equimagnetic field diagram (B)" of "Data analysis (A)" is selected, the isomagnetic diagram screen shown in FIG. 31 is displayed (S-11).
-5), "Propagation time diagram (P)" of "Data analysis (A)"
Is selected, the equal propagation time diagram screen shown in FIG.
11-11), and selecting "time integral diagram (T)" of "data analysis (A)", the isochronous integral diagram screen shown in FIG. 33 is displayed (S-11-7). ,Also,
If "End (X) of magnetocardiographic system" of "File (F)" is selected, the system is ended.

In each screen, if a radio button (circular button in the drawing) in the operation area is clicked, a screen of a waveform or a diagram designated by the click is displayed instead. In FIG. 20, the branch part is not "branch by menu" but "branch by menu or radio button". Therefore, according to this embodiment, various analysis data can be obtained only by clicking the radio button in the operation area without selecting the menu of FIG. 9, so that the operation time can be reduced, Erroneous operation can be reduced and operability can be improved.

In FIGS. 28 to 30, the magnetic flux density in the “scale” box is the value of the full scale on the plus side and the minus side with reference to the zero level (unit: picotesla (pT)). The value is selected in a pull-down menu that is opened by clicking the triangle in the text box. In FIGS. 28 to 33, by clicking a radio box in the “display component” box, a waveform of a normal component or a waveform of a tangent component can be selected and displayed on the screen.

In FIG. 28, the waveform of each channel selected in the channel is displayed with the left end of the analysis data portion adjusted to the offset time. According to the analysis data, it is possible to compare the shapes and sizes of the waveforms of the channels arranged and displayed in the analysis data section in the vertical direction. Similarly, in FIG. 29, the waveforms arranged vertically in FIG. 28 are displayed in an overlapping manner, and the shapes and sizes of the waveforms can be compared.
In FIG. 30, all the channels are the same as those in FIG.
Similar to FIG. 29, it is displayed based on the offset time. Therefore, the operator can select and analyze the number of channels as needed.

In FIG. 31, a vertically elongated magnetic field strength index box 310 is arranged at the right end of the analysis data section. The magnetic field strength index boxes have different colors from each other.
It is divided into compartments. This is to improve visual angle (color) recognizability by distinguishing the intensity range of the magnetic field indicated by each island pattern on the isomagnetic diagram screen shown in FIG. 31 by the type of color. It is. That is, the center position 311 in the longitudinal direction of the magnetic field strength index box 310 is a position where the magnetic field strength is zero, and the sections above the center position are referred to as the first to sixth sections in order from the center position. Thus, for example, the first section has a magnetic field intensity range of 0 to 2 pT, the second section has a magnetic field intensity range of 2 to 4 pT, the third section has a magnetic field intensity range of 4 to 6 pT, and the fourth section has a magnetic field intensity range of 6 to 8 pT. The fifth section corresponds to a field strength range of 8 to 10 pT, and the sixth section corresponds to a field strength range of 10 to 12 pT. The same applies to the section below the center position. However, the section above the center position indicates the magnetic field strength in the plus direction, and the section below the center position indicates the magnetic field strength in the minus direction. The isomagnetic diagram shown in FIG. 31 is displayed in different colors according to the magnetic field strength according to the definition of the correspondence between the magnetic field strength range and the color in the magnetic field strength index box 310. In addition, as a color, the plus side of the magnetic field strength may be a warm color system, the minus side may be a cool color system, and the center may be yellow. Thereby, the strength of the magnetic field can be recognized in color, so that the visibility can be improved. Moreover, according to this embodiment, since the magnetic field strength index box 310 is provided near the analysis data section, the color to be compared, that is, the color assigned to the map and the predetermined color of the magnetic field strength index box 310 are determined. As you can check while comparing the gaze movement without moving much,
The relationship between the level of the magnetic field and the color can be clearly determined. In this embodiment, the magnetic field strength index box 310 is provided at the right end of the analysis data section, but may be in the vicinity of the analysis data section.
It may be on the left.

In FIG. 31, “number of maps” in the “reconstruction parameter” box indicates the number of isomagnetic maps to be displayed, and “maximum value” indicates the number of magnetic field strength index boxes 3.
The term “interval” of the magnetic field strengths corresponding to both ends of 10 means a magnetic field range corresponding to the length of each section in the magnetic field strength index box 310. The value can be selected by clicking the triangle or inverted triangle button in the corresponding text box.

At the bottom of the analysis data display section, the ECG waveform of the reference channel and two map time selection cursors 31 are shown.
1 and 312 are displayed. A division line having the same interval is displayed between the two map time selection cursors 311 and 312, and the number of the lines matches the number of maps selected by the map number selection. In addition, the two map time selection cursors 311 and 312 can move their positions independently in the left and right direction. When the movement changes the distance between the cursors, the distance between the dividing lines also changes. Are always equally spaced. Needless to say, a cursor may be provided for each division line, and each of the division lines may be set individually.
In FIG. 31, the number of displayed isomagnetic maps is 16, but these diagrams are diagrams at the time when the dividing line on the electrocardiogram waveform is located. The time is also displayed so you can see when the map is up to date.

As a result, as described with reference to FIG.
The operator indicates how long (the width of the two cursors 311 and 312) the map currently displayed on the analysis data display section is within the analysis time (the width of the electrocardiographic waveform), and the range indicated by the map. Can be grasped at a glance as to which range is within the analysis time, so that the visibility can be improved. Further, the range indicated by the map can be set by simply moving the two cursors with a mouse operation, so that the operation is easy. Furthermore, if the intervals between the dividing lines are set freely, various analysis environments can be provided to the operator, for example, by denying a questionable part and sparsely setting other parts.

When the check box of the “current direction” in the operation area is clicked to display a check mark, an arrow is displayed on the isomagnetic diagram. The isomagnetic map on which the arrow is displayed is called an arrow map (not shown). For the arrows, the position indicates the position of the channel (position of the magnetic sensor), the length indicates the strength of the magnetic field, and the direction indicates the direction of the current when the direction of the magnetic field is converted into the direction of the current.

FIG. 32 shows an equal propagation time diagram. In this diagram, the starting position of the propagation time (t _{1 in} FIG. 7) is shown.
It is possible to change the point in time by changing the position of the cursor 321 that moves on the reference waveform.
Can be changed by dragging the cursor with a mouse.

FIG. 33 shows two time integral diagrams and one difference diagram. The "difference display" of the isochronous integration diagram can be easily displayed by clicking a check box and displaying a check mark. When “differential display” is checked, four cursors 331 to 331 are displayed on the reference waveform.
34 appears, and furthermore, two isochronous integration diagrams are displayed on the upper left and right as shown, and a difference diagram is displayed on the lower left. 2
The two isochronous diagrams show the magnetocardiogram waveform, and 100 msec to 140 msec and 180 msec set using the cursors 331 and 332 and the cursors 333 and 334 on the reference waveform, respectively.
Based on values integrated over a time range of ~ 240 msec, the respective time ranges are indicated by cursors 331 and 3
32 and the cursors 333 and 334 can be changed by dragging with the mouse, respectively. The difference diagram is 2
It represents the difference between two time integral diagrams. If there is no check mark, only two cursors (for example, cursors 331 and 332) appear for the cursor, and only one isochronous integration diagram is displayed for the time integration diagram. Of course, the integration time can be changed by changing the position of the cursor. Thus, according to this embodiment,
By clicking the check mark on "Show Difference",
Since two sets of cursors for prompting the next operation are displayed, it is possible to shorten the operation time without giving any doubt about the operation.
The time range can be easily set by moving the pair of cursors with the mouse, so that the operability can be improved.

FIG. 21 shows the flow of system adjustment. The flow is branched into five by menu selection (S-1).
5). In this case, the currently displayed data is stored as it is (S-13), and the Φ-V characteristic curve shown in FIG. 34 is displayed (S-14). When "Fully automatic adjustment (A)" of "Data measurement (Q)" is selected,
The adjustment values of I _bias and V _OFF are automatically calculated for the specified channel (S-16) (the automatic calculation will be described later), and the calculated adjustment values are set in the FLL circuit (S-17). The flow returns to step S-14.

[0093] If the "data measurement (Q)" of the "V _OFF adjustment (V)" is selected, V _oFF for the specified channel is computed (S-18) (calculation of V _OFF will be described later), Thereafter, the flow proceeds to step S-17 described above. "Manual adjustment (M)" of "Data measurement (Q)"
Is selected, the manual adjustment dialog box shown in FIG. 12 is opened (S-19). When the operator inputs the adjustment values of I _bias and V _OFF for each channel, the input adjustment values are accepted (S-
20) The adjustment value is set in the FLL circuit by pressing the "OK" button in the dialog box (S-21). The dialog box is thereby closed (S-22), and the flow proceeds to step S-17.

When the "adjustment value file (F)" of "data measurement (Q)" is selected, the flow is further branched into two by a sub pull-down menu (S-22).
That is, the operator inquires the file name by selecting "Open (O)" in the sub pull-down menu, and the operator inputs the file name including the contents of FIG. 11 (S-23). The contents of the adjustment value file are FLL
The circuit is set (S-24). In addition, "data measurement (Q)"-"adjustment value file (F)"-"overwrite save"
Alternatively, the same operation as in step S-23 is performed by selecting "Save As (A)" (S-25),
The adjustment value can be written to the adjustment value file (S-26).

FIG. 22 shows the flow of the automatic calculation in step S-15 in FIG.

S-151: In the case of fully automatic adjustment, the following processing is performed for all SQUID channels one by one. The channel being processed is assumed to be ch.

S-15-2: It is assumed that the calculated bias current and offset voltage are stored in memories named IBIAS and VOFF. IBIAS and VO
The FF can hold a value equal to the number of channels, and the initial values are all set to 0. Let ΔV be the temporarily stored amplitude of the Φ-V characteristic curve.

[0098] S-15-3: For each channel ch, changes in steps of [Delta] I _bias to I _bias specified by the "scan parameters" box in Figure 34 the bias current I _b from 0 (scanning) is, [Phi I _{bias at} which the amplitude ΔV of the −V characteristic curve becomes the largest is defined as the optimum bias current IBIAS (ch) of the channel ch.

S-15-4 to 8: Bias current 0 to I
Until b, the amplitude ΔV of the Φ-V characteristic curve is obtained by the following processing. The external magnetic field Φ given to the SQUID of the channel ch is changed (scanned) from 0 to Φ _ext specified in the “scan parameter” box in FIG. 34 in steps of ΔΦ, and the A / D converted signal is stored. Then, the maximum value Mmax and the minimum value Vmin of the signal are obtained.

S-15-9-10: Here, maximum value M
IBIAS if the difference between _max and the minimum value V _min is greater than ΔV
(Ch) values at I _bias of the value of VOFF (ch) by the average of the maximum value M _max and the minimum value V _min, respectively as the ΔV in the difference between the maximum value V _max and the minimum value V _min. If Trip ΔV holds the previous value is greater than the difference between the maximum value M _max and the minimum value V _min.

[0102] S-15-11: IBIAS when the above processing the bias current I _b is repeated until the I _bias
(Ch) and VOFF (ch) are SQUID channels c
h is the optimum bias current and offset voltage.

S-15-12: By executing the above processing for all the SQUID channels, the fully automatic adjustment ends.

FIG. 23 shows V in step 18 in FIG.
4 shows an OFF adjustment flow.

S-18-1: In the case of V _OFF adjustment, the following processing is performed for all SQUID channels one by one.

S-18-2 to 6: SQ of channel ch
The external magnetic field Φ applied to the UID is changed (scanned) from 0 to Φ _ext specified in the “scan parameter” box in FIG. 34 in steps of ΔΦ, and the maximum value V _{max of the} A / D converted signal is changed. And the minimum value _Vmin .

S-18-7: SQUID channel ch
The optimal offset voltage VOFF (ch) is the maximum value V
It is calculated as the difference between the _max and the minimum value V _min.

S-18-8: The above processing is performed for all SQs
V _OFF by executing for UID channel
The adjustment ends.

[0108]

As described above, according to the present invention, the processing function display, the analysis data display, and the operation item display are performed on the same screen, and the respective displays are associated with each other. By selecting an item and selecting an operation item in the operation area display section, it is possible to easily switch the display content of the analysis data display section while visually checking it. Also, according to the present invention, a processing function display unit that is located at the top of the screen and indicates processing function items including measurement,
A list data display section showing the information of the subject as a list is displayed above the processing function display section, and data such as raw data or processed data of the specified subject is displayed below the list data display section. Since the subject data display unit including the data display unit is provided, the screen becomes easy to see.

[Brief description of the drawings]

FIG. 1 is a schematic configuration diagram of an embodiment of a biomagnetic field measurement apparatus according to the present invention.

FIG. 2 is a perspective view showing an arrangement configuration of a magnetic sensor used in the biomagnetic field measuring apparatus of FIG. 1;

FIG. 3 is used in the biomagnetic field measurement device of FIG.
FIG. 3 is a perspective view of a single magnetic sensor that detects a normal component of a magnetic field.

4 is used in the biomagnetic field measurement device of FIG.
FIG. 3 is a perspective view of a single magnetic sensor that detects a normal component of a magnetic field.

FIG. 5 is a diagram showing a positional relationship between a magnetic sensor and a chest of a subject in the biomagnetic field measuring apparatus in FIG. 1;

FIG. 6 is a time waveform chart of each component of a healthy person's biomagnetic field (cardiac magnetism) measured by each magnetic sensor in the biomagnetic field measuring apparatus of FIG. 1;

FIG. 7 is a diagram showing a time waveform of a tangential component of a magnetocardiogram of two specific channels measured on a healthy person in the biomagnetic field measuring apparatus of FIG. 1;

FIG. 8 is a diagram showing a basic layout of a display screen displayed on a display unit in the biomagnetic field measuring apparatus of FIG. 1;

9 is a diagram showing an operation menu in a menu bar section of a display screen displayed on a display unit in the biomagnetic field measurement device of FIG.

10 is a subject opened when “list (L)”-“registration (R)” is selected as an operation menu on a display screen displayed on the display unit in the biomagnetic field measurement apparatus of FIG. The figure which shows the content of the registration dialog box.

11 is a search dialog box that is opened when “list (L)”-“search (S)” is selected as an operation menu in a display screen displayed on the display unit in the biomagnetic field measurement apparatus of FIG. FIG.

12 is a manual that is opened when “data measurement (Q)”-“manual adjustment (M)” is selected as an operation menu on a display screen displayed on the display unit in the biomagnetic field measurement apparatus of FIG. The figure which shows the content of the adjustment dialog box.

FIG. 13 is an automatic menu that is opened when “data measurement (Q)”-“measurement panel (P)” is selected as an operation menu in a display screen displayed on the display unit in the biomagnetic field measurement apparatus of FIG. 1; The figure which shows the content of a diagnosis dialog box.

14 is a diagram showing a heat flash operation dialog box opened when a “heat flash” button is pressed when the display screen of FIG. 25 or FIG. 26 is displayed on the display unit in the biomagnetic field measurement apparatus of FIG. 1; The figure which shows the content.

FIG. 15 is a diagram showing a measurement progress bar displayed on a display unit during measurement in the biomagnetic field measurement device of FIG. 1;

FIG. 16 is a diagram showing a flow of an overall operation performed in the biomagnetic field measurement apparatus of FIG. 1;

FIG. 17 is a diagram showing a flow of subject selection in a subject selection step in the operation flow of FIG. 16;

FIG. 18 is a diagram showing a flow of data measurement in a data measurement step in the operation flow of FIG. 16;

FIG. 19 is a diagram showing a flow of an averaging process in an averaging process step in the operation flow of FIG. 16;

FIG. 20 is a diagram showing a flow of data analysis in a data analysis step in the operation flow of FIG. 16;

FIG. 21 is a diagram showing a flow of system adjustment performed in the biomagnetic field measuring apparatus of FIG. 1;

FIG. 22 is a view showing a flow of automatic calculation in an automatic calculation step in the system adjustment flow of FIG. 21.

FIG. 23 is a diagram showing a V _OFF adjustment flow in V _OFF adjustment step in the system adjusts the flow of FIG. 21.

FIG. 24 is a view showing a subject list screen displayed on a display unit of the biomagnetic field measuring apparatus of FIG. 1;

FIG. 25 is a view showing a data measurement screen displayed on a display unit of the biomagnetic field measurement apparatus of FIG. 1;

FIG. 26 is a view showing a waveform confirmation screen displayed on the display unit of the biomagnetic field measurement apparatus of FIG. 1 when measurement is completed.

FIG. 27 is a diagram showing an averaging screen displayed on a display unit of the biomagnetic field measuring apparatus in FIG. 1;

FIG. 28 is a diagram showing a single waveform display screen displayed on a display unit of the biomagnetic field measuring apparatus of FIG. 1;

FIG. 29 is a diagram showing a superimposed waveform display screen displayed on the display unit of the biomagnetic field measuring apparatus in FIG. 1;

FIG. 30 is a view showing a grid map display screen displayed on a display unit of the biomagnetic field measurement apparatus of FIG. 1;

FIG. 31 is a view showing an isomagnetic map display screen displayed on the display unit of the biomagnetic field measuring apparatus in FIG. 1;

FIG. 32 is a diagram showing a propagation time diagram display screen displayed on the display unit of the biomagnetic field measuring apparatus in FIG. 1;

FIG. 33 is a diagram showing a time integration diagram display screen displayed on the display unit of the biomagnetic field measurement apparatus in FIG. 1;

FIG. 34 is a view showing a system adjustment screen displayed on a display unit of the biomagnetic field measuring apparatus of FIG. 1;

[Explanation of symbols]

1: magnetic shield room, 2: subject, 3: bed,
4: Dewar, 5: Automatic replenishing device, 6: FLL circuit, 7:
Amplifier / filter / amplifier, 8: computer, 8-1: display unit, 8-2: keyboard, 8-3: mouse,
20-1 to 20-8, 21-1 to 21-8, 22-1 to
22-8, 23-1 to 23-8, 241-1 to 24-8,
25-1 to 25-8, 26-1 to 26-8 and 27-1
27-8: magnetic sensor, 10, 10 'and 10 "and 11, 11' and 11": coil, 12, 12 'and 12 ": SQUID, 13 and 14: sensor, 30: chest, 261: scroll box , 262: scroll bar, 271: threshold value cursor, 273 to 275: slider cursor, 311, 312 and 331 to 33
4: cursor, 801: title bar section, 802: menu bar section, 803: toolbar section, 804: subject information section, 805: analysis data section, 806: operation area section, 8
08: status bar section, 807-1: message bar section, 807-2: date and time display section, 808 to 814: icons.

──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Hiroyuki Suzuki 882 Ma, Hitachinaka-shi, Ibaraki Pref.Hitachi, Ltd.Measurement Equipment Division (72) Inventor Keiji Tsukada 1-280, Higashi-Koigakubo, Kokubunji-shi, Tokyo Hitachi, Ltd. In the Central Research Laboratory (56) References JP-A-2-40578 (JP, A) JP-A-6-237917 (JP, A) JP-A-4-35643 (JP, A) JP-A-7-184871 (JP, A) A) JP-A-7-194600 (JP, A) JP-A-7-129754 (JP, A) JP-A-8-266499 (JP, A) JP-A-4-141140 (JP, A) JP-A-11 -4815 (JP, A) JP-A-11-4814 (JP, A) JP-A-10-295661 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61B 5/05

Claims (15)

(57) [Claims] 1. A biological magnetic field map display device for measuring a subject's biomagnetic field at a plurality of positions and displaying a magnetic field map as a processing result thereof, comprising: a processing function display unit showing processing function items including measurement; An operation area display section including an AFA parameter setting display, and an analysis data display section displaying data measured under the conditions of the set AFA parameters , and a processing function display, an operation area display, A set above
A biological magnetic field map display device that performs display processing of analysis data display showing data measured under the conditions of FA parameters . 2. The apparatus according to claim 1, wherein the AFA parameter setting display has an HPF setting display. 3. The biological magnetic field map display device according to claim 1, wherein the operation area display unit includes a measurement time setting display for setting a measurement time. 4. The apparatus according to claim 1, wherein the operation area display unit has a display for setting a measurement interval. 5. The operation area display section according to claim 1, wherein the operation area display section has a scale setting display for setting a horizontal time scale of an output display on the analysis data display section, and the measured data is set. A biological magnetic field map display device, comprising: an analysis data display unit for displaying the data on a time scale. 6. The biological magnetic field map display device according to claim 1, wherein the operation area display unit includes a display of a measurement start button for instructing start of measurement. 7. A biological magnetic field map display device for measuring a biomagnetic field of a subject at a plurality of positions and displaying a magnetic field map as a processing result thereof, comprising: a processing function display unit showing processing function items including measurement; An operation area display unit including a magnetic field lock setting display for setting or canceling the magnetic field lock of the superconducting quantum interference device at the measurement point, and an analysis data display unit for displaying data measured at the measurement point, In addition, a biological magnetic field map display device that performs display processing of processing function display, operation area display, and analysis data display indicating data measured at measurement points on the same screen. 8. A method for displaying a magnetic field diagram of a living body in which a biomagnetic field of a subject is measured at a plurality of positions and a resulting magnetic field diagram is displayed, wherein a processing function item including the measurement is displayed on a processing function display section. Then, the AFA parameter setting display is displayed on the operation area display section, and the AFA parameter set on the analysis data display section is displayed .
Display data measured under the conditions, and the same screen to the processing function display, the display processing of the operation area display and shows the data measured with the set condition of the AFA parameter in the analysis data display unit analyzes data display To display the magnetic field of a living body. 9. The method according to claim 8, wherein a measurement time setting display for setting a measurement time is displayed on the operation area display unit. 10. The method according to claim 9, wherein a display for setting a measurement interval is displayed on the operation area display unit. 11. The magnetic field diagram of a living body according to claim 8, wherein a scale setting display for setting a horizontal time scale of an output display on the analysis data display unit is provided on the operation area display unit. Display method. 12. The method for displaying a magnetic field map of a living body according to claim 8, wherein a measurement start button for instructing start of measurement is displayed on the operation area display unit. 13. The method according to claim 12, wherein the AFA parameter setting display has an HPF setting display. 14. A biological magnetic field map display device for measuring a subject's biomagnetic field at a plurality of positions and displaying a magnetic field map as a processing result thereof, wherein a processing function item including measurement is displayed on a processing function display section. Then, a magnetic field lock setting display for setting the magnetic field lock of the superconducting quantum interference device at the measurement point is displayed on the operation area display section, and the data measured at the measurement point is displayed on the analysis data display section, and the same. A method of displaying a magnetic field of a living body, which performs display processing of a processing function display on a screen, an operation area display, and an analysis data display showing data measured at the measurement points. 15. A biological magnetic field map display device for measuring a biomagnetic field of a subject at a plurality of positions and displaying a magnetic field map as a result of the processing, a processing function display unit showing processing function items including measurement. An operation area display section including an AFA parameter setting display; an analysis data display section displaying data measured under the conditions of the set AFA parameters; and a processing function display, an operation area display, A set above
Performing display processing of an analysis data display indicating data measured under the conditions of the FA parameter; the operation area display unit displays a magnetic field lock setting for setting or releasing a magnetic field lock of the superconducting quantum interference device at the measurement point; Magnetic field display device.