JP2008032695A - Panel for analysis and analysis device using the same - Google Patents

Panel for analysis and analysis device using the same Download PDF

Info

Publication number
JP2008032695A
JP2008032695A JP2007168311A JP2007168311A JP2008032695A JP 2008032695 A JP2008032695 A JP 2008032695A JP 2007168311 A JP2007168311 A JP 2007168311A JP 2007168311 A JP2007168311 A JP 2007168311A JP 2008032695 A JP2008032695 A JP 2008032695A
Authority
JP
Japan
Prior art keywords
analysis
inlet
panel
sample liquid
chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007168311A
Other languages
Japanese (ja)
Other versions
JP4859769B2 (en
Inventor
Hirobumi Sugimoto
博文 杉本
Masaaki Kito
正明 木藤
Masakazu Mori
政和 森
Shinichi Ninomiya
進一 二宮
Noriyuki Shinohara
紀行 篠原
Hiroshi Takano
浩 高野
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Panasonic Holdings Corp
Original Assignee
Matsushita Electric Industrial Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matsushita Electric Industrial Co Ltd filed Critical Matsushita Electric Industrial Co Ltd
Priority to JP2007168311A priority Critical patent/JP4859769B2/en
Publication of JP2008032695A publication Critical patent/JP2008032695A/en
Application granted granted Critical
Publication of JP4859769B2 publication Critical patent/JP4859769B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Abstract

<P>PROBLEM TO BE SOLVED: To provide a panel for analysis capable of preventing contamination and a shortage of sample solution even if the sample solution is attached to a periphery of an inlet. <P>SOLUTION: A chamber with which sample solution spotted to an inlet 14 is transferred is placed inside a panel 3 for analysis. The inlet 14 is formed protruding in a direction separating away from the chamber. A recess 12 is formed around the inlet 14. The inlet 14 is positioned on a panel holding member 101 for analysis of an analysis device on a center of rotation axis side so as to optically access and analyze the chamber by rotating the panel holding member 101 for analysis. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

本発明は、試料液と分析試薬との反応状態を測定するための分析用パネル及び分析装置に関するものであり、より詳細には、分析装置で試料液の成分測定に使用する分析用パネルにおける注入口の構造と注入口近傍に付着した試料液の移送手段に関する。   The present invention relates to an analysis panel and an analysis apparatus for measuring a reaction state between a sample solution and an analysis reagent, and more specifically, a note on an analysis panel used for measuring a component of a sample solution in the analysis apparatus. The present invention relates to an inlet structure and a means for transferring sample liquid adhering to the vicinity of the inlet.

従来、試料液を内部にセットした分析用パネルを用い、この分析用パネルを取り付けた分析用ディスクを軸心回りに回転させながら、光学スキャン技術を用いて、前記試料液の特性を分析する分析装置が実用化されている。   Conventionally, an analysis panel in which a sample solution is set inside is used, and an analysis disk to which the analysis panel is attached is rotated around an axis while analyzing the characteristics of the sample solution using an optical scanning technique. The device has been put into practical use.

近年、試料液の少量化、装置の小型化、短時間測定、多項目同時測定など、市場からの要求も多く、血液等の試料液をいろいろな分析試薬と反応させ、その混合物を検出し、短時間で各種病気の進行度合いを検査することができる、より高精度の分析装置が望まれている。   In recent years, there have been many demands from the market, such as sample volume reduction, device miniaturization, short time measurement, multi-item simultaneous measurement, etc., reacting sample liquids such as blood with various analytical reagents, detecting the mixture, There is a demand for a more accurate analyzer that can inspect the progress of various diseases in a short time.

例えば特許文献１などには、図２０（ａ）（ｂ）に示す構成が記載されている。
これは、図２０（ｂ）に示すように、分析用ディスク２０１の分析用パネル保持部２０４に分析用パネル２０３を装着した状態にし、図２０（ａ）に示すこの分析用ディスク２０１を、回転軸心２０２の回りに回転させて試料液を光学的に分析する。 For example, Patent Document 1 describes a configuration shown in FIGS. 20 (a) and 20 (b).
As shown in FIG. 20B, the analysis panel 203 is mounted on the analysis panel holding unit 204 of the analysis disk 201, and the analysis disk 201 shown in FIG. The sample liquid is optically analyzed by rotating around the axis 202.

分析用ディスク２０１に着脱自在の前記分析用パネル２０３は、試料液の注入口２１４と、注入口２１４と通じるキャビティ２０８と、キャビティ２０８に通じる空気口２１０とを備えており、注入口２１４は分析用パネル２０３の端面に形成されることにより試料液を注入しやすくさせるとともに、分析用ディスク２０１には、分析用パネル２０３の注入口２１４の位置に対応して吸収部材２１５が形成されており、吸収部材２１５は分析用パネル２０３の注入口２１４の周囲に付着した試料液を適量だけ吸収する。また、分析用パネル２０３を分析用パネル保持部２０４に装着した状態では、分析用パネル２０３の注入口２１４が吸収部材２１５によって密閉される。   The analysis panel 203 detachably attached to the analysis disk 201 includes a sample solution injection port 214, a cavity 208 communicating with the injection port 214, and an air port 210 communicating with the cavity 208. In addition to facilitating the injection of the sample solution by being formed on the end face of the panel for analysis 203, an absorption member 215 is formed on the analysis disk 201 corresponding to the position of the inlet 214 of the panel for analysis 203, The absorbing member 215 absorbs an appropriate amount of the sample liquid attached around the inlet 214 of the analysis panel 203. When the analysis panel 203 is attached to the analysis panel holding unit 204, the inlet 214 of the analysis panel 203 is sealed with the absorbing member 215.

分析用パネル２０３のキャビティ２０８は、注入口２１４および空気口２１０よりも分析用ディスク２０１の外周に位置するように流路が形成されており、キャビティ２０８の流路の途中には、試料液と反応するための分析試薬２０９が塗布されている。   A channel is formed in the cavity 208 of the analysis panel 203 so as to be positioned on the outer periphery of the analysis disk 201 with respect to the inlet 214 and the air port 210. An analysis reagent 209 for reacting is applied.

この分析用パネル２０３を用いた分析動作は、分析用パネル２０３を分析用ディスク２０１から取り外した状態で、分析用パネル２０３の注入口２１４に試料液を点着すると、試料液は注入口２１４と連通するキャビティ２０８内へ毛細管力により移送される。   In the analysis operation using the analysis panel 203, when the sample liquid is spotted on the inlet 214 of the analysis panel 203 in a state where the analysis panel 203 is detached from the analysis disk 201, the sample liquid is separated from the inlet 214. It is transferred by capillary force into the communicating cavity 208.

試料液をセットした分析用パネル２０３を、分析用ディスク２０１の分析用パネル保持部２０４に装着すると、分析用ディスク２０１によって注入口２１４の開口部が閉鎖される。このとき、注入口２１４の端面に付着した試料液は、吸収部材２１５と接触することによって吸収されるので、注入口２１４と対向する位置への試料液の付着や、分析用ディスク２０１の回転中の試料液の飛散などを防止することができ、以降の試料液の分析試験を安全に行うことができる。
特開２００３−１８５６７１公報 When the analysis panel 203 on which the sample solution is set is attached to the analysis panel holding unit 204 of the analysis disk 201, the opening of the inlet 214 is closed by the analysis disk 201. At this time, the sample liquid adhering to the end face of the injection port 214 is absorbed by coming into contact with the absorbing member 215, so that the sample liquid adheres to the position facing the injection port 214 and the analysis disk 201 is rotating. The sample liquid can be prevented from scattering and the subsequent analysis of the sample liquid can be performed safely.
JP 2003-185671 A

しかしながら、注入口２１４の周囲に付着した試料液を、吸収部材２１５で吸引する場合には、分析用パネル２０３のキャビティ２０８に注入された試料液も吸収部材２１５で吸引されていまい、分析試薬２０９との混合時に必要な試料液が不足して、分析試薬２０９と試料液との反応状態の測定に影響を及ぼすという課題を有している。   However, when the sample liquid adhering to the periphery of the inlet 214 is sucked by the absorption member 215, the sample liquid injected into the cavity 208 of the analysis panel 203 is not sucked by the absorption member 215, and the analysis reagent 209 The sample solution required at the time of mixing is insufficient, which has a problem of affecting the measurement of the reaction state between the analytical reagent 209 and the sample solution.

また、吸収部材２１５が分析用ディスク２０１の側に設けられているので、分析用ディスク２０１の使用を繰り返した場合には、分析用パネル２０３を分析用ディスク２０１に装着して分析する度に、注入口２１４の周囲に付着した試料液を吸収部材２１５で吸引することになるので、吸引部材２１５が試料液で次第に汚染されていく。これは、測定しようとする試料液に、汚染された物質が混入して測定に悪影響を及ぼしたり、作業者が汚染した吸収部材２１５に触れることによって、病気などに感染したりする恐れも生じさせる。また、分析の度に、吸収部材２１５を新しいものと交換したり、洗浄したりするなど手間がかかる作業が生じ、安全管理の面でも難しい課題がある。   In addition, since the absorbing member 215 is provided on the analysis disk 201 side, when the analysis disk 201 is repeatedly used, the analysis panel 203 is mounted on the analysis disk 201 and analyzed. Since the sample liquid adhering to the periphery of the inlet 214 is sucked by the absorption member 215, the suction member 215 is gradually contaminated with the sample liquid. This causes a possibility that a contaminated substance is mixed into the sample liquid to be measured to adversely affect the measurement, or that the operator touches the contaminated absorbing member 215 to infect a disease or the like. . Further, every time analysis is performed, laborious work such as replacement of the absorbing member 215 with a new one or cleaning is caused, and there is a difficult problem in terms of safety management.

そこで本発明は、上記課題を解決するものであり、たとえ、注入口２１４の周囲に試料液が付着した場合にでも、試料液の不足や、汚染防止など測定に影響を及ぼす事態の発生を防止できる分析用パネル及びそれを用いた分析装置を提供する。   Therefore, the present invention solves the above-mentioned problems, and prevents the occurrence of a situation that affects measurement, such as lack of sample liquid and prevention of contamination, even when the sample liquid adheres around the inlet 214. An analysis panel that can be used and an analysis apparatus using the same are provided.

本発明の請求項１記載の分析用パネルは、パネル本体の一側面に試料液の注入口が設けられ、前記パネル本体の内部に前記注入口に連通して前記注入口に点着された試料液が移送されるチャンバーが設けられ、前記注入口を回転軸心側に配置した状態で前記パネル本体を回転させて、前記チャンバーで前記試料液中の成分の分析を行う分析用パネルであって、前記注入口は、パネル本体の前記一側面よりチャンバーから離れる方向に突出した形状であるとともに、パネル本体の前記一側面前で前記注入口の周囲には凹部を形成したことを特徴とする。   The analysis panel according to claim 1 of the present invention is a sample in which an inlet for a sample liquid is provided on one side surface of the panel body, and the sample body is spotted on the inlet in communication with the inlet in the panel body. An analysis panel for analyzing a component in the sample liquid by rotating the panel body in a state in which a chamber for transferring the liquid is provided and the injection port is disposed on the rotation axis side; The inlet has a shape protruding from the one side of the panel body in a direction away from the chamber, and a recess is formed around the inlet before the one side of the panel body.

本発明の請求項２記載の分析用パネルは、請求項１において、前記注入口の突出量を、パネル本体の一側面とほぼ同等としたことを特徴とする。
本発明の請求項３記載の分析用パネルは、請求項１において、前記凹部の開口部の断面積は、凹部の奥端における断面積よりも同等以上の大きさであることを特徴とする。 The analysis panel according to claim 2 of the present invention is characterized in that, in claim 1, the amount of protrusion of the inlet is substantially equal to one side surface of the panel main body.
The analysis panel according to claim 3 of the present invention is characterized in that, in claim 1, the cross-sectional area of the opening of the concave portion is equal to or larger than the cross-sectional area at the back end of the concave portion.

本発明の請求項４記載の分析用パネルは、請求項１において、前記注入口は、前記凹部の底面を基端として突出していることを特徴とする。
本発明の請求項５記載の分析用パネルは、請求項１において、前記凹部の容積は、前記注入口への試料液の点着時に、前記注入口近傍に付着した試料液を受容できる大きさであることを特徴とする。 The analysis panel according to claim 4 of the present invention is characterized in that, in claim 1, the injection port protrudes with the bottom surface of the recess as a base end.
The analysis panel according to claim 5 of the present invention is the analysis panel according to claim 1, wherein the volume of the recess is large enough to accept the sample liquid adhering to the vicinity of the inlet when the sample liquid is spotted on the inlet. It is characterized by being.

本発明の請求項６記載の分析用パネルは、請求項１において、前記凹部に、前記試料液を吸収する吸収部材を配置したことを特徴とする。
本発明の請求項７記載の分析用パネルは、請求項６において、前記吸収部材を、前記軸心回りの回転により発生する遠心力によって凹部に移送された試料液に接触する位置に配置したことを特徴とする。
本発明の請求項８記載の分析用パネルは、請求項１において、前記凹部に連通して、毛細管力により試料液を保持する溝部を形成したことを特徴とする。 The analysis panel according to claim 6 of the present invention is characterized in that, in claim 1, an absorbing member that absorbs the sample solution is disposed in the recess.
The analysis panel according to claim 7 of the present invention is the analysis panel according to claim 6, wherein the absorbing member is arranged at a position in contact with the sample liquid transferred to the recess by the centrifugal force generated by the rotation around the axis. It is characterized by.
The analysis panel according to an eighth aspect of the present invention is characterized in that, in the first aspect, a groove portion is formed which communicates with the concave portion and holds the sample liquid by a capillary force.

本発明の請求項９記載の分析用パネルは、請求項８において、前記溝部は、前記凹部の底部に連通していることを特徴とする。
本発明の請求項１０記載の分析用パネルは、請求項８において、前記溝部は、前記軸心回りの回転により発生する遠心力によって、凹部に移送された試料液が、さらに前記遠心力によって内部に移送される形状であることを特徴とする。 The analysis panel according to claim 9 of the present invention is characterized in that, in claim 8, the groove portion communicates with a bottom portion of the recess.
The analysis panel according to claim 10 of the present invention is the analysis panel according to claim 8, wherein the groove portion has a sample liquid transferred to the concave portion due to a centrifugal force generated by the rotation around the axis, and the centrifugal force further includes an internal portion of the sample liquid. It is the shape conveyed by this.

本発明の請求項１１記載の分析用パネルは、請求項１において、前記凹部は、前記チャンバーと連通していることを特徴とする。
本発明の請求項１２記載の分析用パネルは、請求項１１において、前記凹部と前記チャンバーとを連通する通路を、注入口の近傍に付着した試料液が、前記軸心回りの回転により発生する遠心力によって前記チャンバー内に移送されるよう構成したことを特徴とする。 The analysis panel according to claim 11 of the present invention is characterized in that, in claim 1, the recess communicates with the chamber.
According to a twelfth aspect of the present invention, in the analysis panel according to the twelfth aspect, the sample liquid adhering to the vicinity of the inlet through the passage communicating the concave portion and the chamber is generated by rotation around the axis. It is configured to be transferred into the chamber by centrifugal force.

本発明の請求項１３記載の分析用パネルは、請求項１において、前記注入口に連通した前記チャンバーに、試料液としての血液の分析に使用する分析試薬を有することを特徴とする。   The analysis panel according to claim 13 of the present invention is characterized in that, in claim 1, the chamber communicated with the inlet has an analysis reagent used for analyzing blood as a sample solution.

本発明の請求項１４記載の分析用パネルは、請求項１において、前記注入口と前記凹部を覆う開閉可能なカバーを備えたことを特徴とする。
本発明の請求項１５記載の分析用パネルは、請求項１において、前記注入口と前記凹部を覆う開閉可能なカバーを備え、前記カバーの内側に試料液を吸収する吸収部材を設けたことを特徴とする。 The analysis panel according to a fourteenth aspect of the present invention is characterized in that in the first aspect, an openable / closable cover for covering the inlet and the recess is provided.
The analysis panel according to claim 15 of the present invention is the analysis panel according to claim 1, further comprising an openable / closable cover that covers the inlet and the recess, and an absorption member that absorbs the sample liquid is provided inside the cover. Features.

本発明の請求項１６記載の分析用パネルは、請求項１において、前記注入口と前記凹部を覆う開閉可能なカバーを備え、前記カバーの内側に試料液を吸収する吸収部材を設け、前記注入口と前記吸収部材との間に空隙を形成したことを特徴とする。   The analysis panel according to a sixteenth aspect of the present invention is the analysis panel according to the first aspect, further comprising an openable / closable cover that covers the inlet and the recess, and an absorption member that absorbs the sample liquid is provided inside the cover. A gap is formed between the inlet and the absorbing member.

本発明の請求項１７記載の分析用パネルは、請求項１において、前記チャンバーは、前記注入口に点着された試料液を一時的に保持する保持チャンバーと、分析に必要な分析試薬を保持する試薬チャンバーと、前記保持チャンバーに保持された試料液と前記分析試薬とが移送され、両者を混合させるとともに分析試薬と混合された試料液の測定が行われる測定チャンバー領域とを備えることを特徴とする。   The analysis panel according to a seventeenth aspect of the present invention is the analysis panel according to the first aspect, wherein the chamber holds a holding chamber for temporarily holding the sample liquid spotted on the inlet and an analysis reagent necessary for the analysis. And a measurement chamber region in which the sample liquid held in the holding chamber and the analysis reagent are transferred, mixed with each other, and measurement of the sample liquid mixed with the analysis reagent is performed. And

本発明の請求項１８記載の分析用パネルは、請求項１，請求項１２，請求項１４のいずれかにおいて、前記注入口の周縁部の表面、前記凹部、前記凹部と前記チャンバーとを連通する通路、前記カバー部材の内面うちの少なくとも何れかに界面活性剤が塗布されていることを特徴とする。   The analysis panel according to an eighteenth aspect of the present invention is the analysis panel according to any one of the first, twelfth, and fourteenth aspects, wherein the peripheral surface of the inlet, the concave portion, the concave portion and the chamber communicate with each other. A surfactant is applied to at least one of the passage and the inner surface of the cover member.

本発明の請求項１９記載の分析装置は、パネル本体の一側面に設けられた試料液の注入口に連通して前記注入口に点着された試料液が移送されるチャンバーが内部に設けられた分析用パネルと、前記分析用パネルが装着される分析用パネル保持部材と、前記分析用パネル保持部材を回転させて発生した遠心力によって前記注入口に点着された試料液をチャンバーに移送し、前記チャンバーの試料液に対して光学的にアクセスして信号を検出して分析処理する分析装置であって、前記分析用パネルに前記注入口を覆う開閉可能なカバーを設け、前記カバーが閉じられた状態の前記分析用パネルを、前記注入口が前記分析用パネル保持部材の回転軸心を横切るよう前記分析用パネル保持部材に装着して分析動作するよう構成したことを特徴とする。   According to a nineteenth aspect of the present invention, there is provided an analysis chamber according to the present invention, wherein a chamber is provided in the chamber to communicate with a sample liquid injection port provided on one side of the panel body and to transfer a sample liquid spotted on the injection port. An analysis panel, an analysis panel holding member on which the analysis panel is mounted, and a sample liquid spotted on the inlet by the centrifugal force generated by rotating the analysis panel holding member. And an analytical device for optically accessing the sample liquid in the chamber to detect and analyze a signal, wherein the analytical panel is provided with an openable / closable cover for covering the inlet. The analysis panel in a closed state is configured to perform an analysis operation by being attached to the analysis panel holding member so that the inlet crosses the rotational axis of the analysis panel holding member.

本発明の請求項２０記載の分析装置は、請求項１９において、前記カバーの内側に試料液を吸収する吸収部材を設けたことを特徴とする。
本発明の請求項２１記載の分析装置は、請求項１９において、前記カバーの内側に、分析用パネルの前記注入口の近傍に付着していた試料液滴を捕集する凹部を設けたことを特徴とする。 The analyzer according to claim 20 of the present invention is characterized in that, in claim 19, an absorption member for absorbing the sample liquid is provided inside the cover.
According to a twenty-first aspect of the present invention, there is provided the analyzer according to the nineteenth aspect, wherein a recess for collecting the sample droplet adhering to the vicinity of the inlet of the analysis panel is provided inside the cover. Features.

本発明の請求項２２記載の分析装置は、請求項２１において、前記凹部に毛細管力により試料液を保持する溝を形成したことを特徴とする。
本発明の請求項２３記載の分析装置は、請求項１９において、分析用パネルの前記注入口の周縁部の表面、前記カバー部材の内面のうちの少なくとも何れかに界面活性剤が塗布されていることを特徴とする。 According to a twenty-second aspect of the present invention, in the twenty-first aspect, a groove for holding a sample solution by a capillary force is formed in the concave portion.
According to a twenty-third aspect of the present invention, in the nineteenth aspect, a surfactant is applied to at least one of the peripheral surface of the inlet of the analysis panel and the inner surface of the cover member. It is characterized by that.

本発明の請求項２４記載の分析装置は、請求項１〜請求項８のいずれかに記載の分析用パネルと、前記分析用パネルが装着される分析用パネル保持部材と、前記分析用パネル保持部材を回転させて発生した遠心力によって前記注入口に点着された試料液をチャンバーに移送し、前記チャンバーの試料液に対して光学的にアクセスして信号を検出して分析処理する分析装置であって、前記分析用パネルを、前記注入口が前記分析用パネル保持部材の回転軸心寄りも外周側、または前記注入口が前記分析用パネル保持部材の回転軸心を横切るように、前記分析用パネル保持部材に装着して分析動作するよう構成したことを特徴とする。   According to a twenty-fourth aspect of the present invention, there is provided an analysis panel according to any one of the first to eighth aspects, an analysis panel holding member to which the analysis panel is mounted, and the analysis panel holding. An analyzer for transferring a sample liquid spotted on the inlet by a centrifugal force generated by rotating a member to the chamber and optically accessing the sample liquid in the chamber to detect and analyze the signal The analysis panel may be arranged such that the injection port is closer to the outer peripheral side of the analysis panel holding member than the rotation axis, or the injection port crosses the rotation axis of the analysis panel holding member. The analysis panel is mounted on the analysis panel holding member to perform an analysis operation.

本発明の請求項２５記載の分析用パネルは、パネル本体の一側面に試料液の注入口が設けられ、前記パネル本体の内部に前記注入口に連通して前記注入口に点着された試料液が移送されるチャンバーが設けられ、前記パネル本体を軸心周りに回転させて、前記チャンバーで前記試料液中の成分の分析を行う分析用パネルであって、前記注入口は、パネル本体の前記一側面よりチャンバーから離れる方向に突出した形状であるとともに、前記注入口を覆う開閉可能なカバーを前記パネル本体に設け、前記カバーの内側に、前記注入口の近傍に付着していた試料液滴を捕集する凹部または前記試料液滴を吸収する吸収部材を設け、前記カバーが閉じられた状態では、前記注入口と前記凹部との間、または、前記注入口と前記吸収部材との間には空隙を形成したことを特徴とする。   In the analysis panel according to claim 25 of the present invention, a sample liquid inlet is provided on one side surface of the panel body, and the sample communicated with the inlet inside the panel body and spotted on the inlet. A chamber through which the liquid is transferred, the panel body is rotated about an axis, and an analysis panel for analyzing the components in the sample liquid in the chamber is provided. The sample liquid has a shape protruding in a direction away from the chamber from the one side surface, and an openable / closable cover for covering the injection port is provided on the panel body, and is attached to the inside of the cover in the vicinity of the injection port. A recess for collecting droplets or an absorption member for absorbing the sample droplet is provided, and when the cover is closed, between the injection port and the recess, or between the injection port and the absorption member. In the sky Characterized in that the formation of the.

本発明の分析用パネルは、パネル本体の一側面に設けられた注入口が、パネル本体の前記一側面よりチャンバーから離れる方向に突出した形状であるとともに、パネル本体の前記一側面前で前記注入口の周囲には凹部を形成したため、前記注入口を回転軸心側に配置した状態で前記パネル本体を回転させて、前記チャンバーで前記試料液中の成分の分析を行った場合に、遠心力が発生すると、注入口の周囲に付着した試料液は、確実に凹部へ移送され収集され、チャンバー内に注入された試料液がチャンバー外に逆方向に放出されるのを防ぐという効果が得られる。   In the analysis panel of the present invention, the injection port provided on one side surface of the panel main body has a shape protruding in a direction away from the chamber from the one side surface of the panel main body, and the injection is performed in front of the one side surface of the panel main body. Since a concave portion is formed around the inlet, the centrifugal force is generated when the panel body is rotated with the inlet arranged on the rotation axis side and the components in the sample solution are analyzed in the chamber. When this occurs, the sample liquid adhering to the periphery of the injection port is reliably transferred to the recess and collected, and the effect of preventing the sample liquid injected into the chamber from being discharged in the reverse direction outside the chamber is obtained. .

また、本発明の分析装置は、パネル本体の一側面に設けられた試料液の注入口に連通して前記注入口に点着された試料液が移送されるチャンバーが内部に設けられた分析用パネルと、前記分析用パネルが装着される分析用パネル保持部材と、前記分析用パネル保持部材を回転させて発生した遠心力によって前記注入口に点着された試料液をチャンバーに移送し、前記チャンバーの試料液に対して光学的にアクセスして信号を検出して分析処理する分析装置であって、前記分析用パネルに前記注入口を覆う開閉可能なカバーを設け、前記カバーが閉じられた状態の前記分析用パネルを、前記注入口が前記分析用パネル保持部材の回転軸心を横切るよう前記分析用パネル保持部材に装着して分析動作するよう構成したため、前記分析用パネル保持部材が移転して遠心力が発生すると、注入口に点着された試料液は前記チャンバーに向かって移送される。また、前記点着の際に注入口の周囲に付着した試料液は、チャンバーとは逆方向に向かって移動して確実に前記カバーに収集されて、外部に飛散して汚染することを防ぐことができる効果が得られる。   Further, the analyzer of the present invention is provided for analysis in which a chamber is provided in which a sample liquid spotted at the inlet is transferred to and communicated with an inlet of a sample liquid provided on one side of the panel body. A panel, an analysis panel holding member on which the analysis panel is mounted, a sample solution spotted on the inlet by centrifugal force generated by rotating the analysis panel holding member, An analyzer for optically accessing a sample liquid in a chamber to detect and analyze a signal, wherein an openable / closable cover for covering the inlet is provided on the analysis panel, and the cover is closed The analysis panel in the state is configured to perform an analysis operation by being attached to the analysis panel holding member so that the inlet crosses the rotational axis of the analysis panel holding member. When wood is centrifugal force to resettlement, sample liquid is spotted on the inlet is transported toward the chamber. In addition, the sample liquid adhering to the periphery of the injection port at the time of spotting moves in the opposite direction to the chamber and is surely collected in the cover to prevent it from being scattered outside and contaminated. The effect that can be obtained.

以下に、本発明の各実施の形態を図１〜図１９に基づいて説明する。
（実施の形態１）
図１〜図６は本発明の実施の形態１を示す。 Hereinafter, embodiments of the present invention will be described with reference to FIGS.
(Embodiment 1)
1 to 6 show Embodiment 1 of the present invention.

図１は本発明の分析用パネル３を示し、図２はその分解図を示す。
分析用パネル３は、上部基板１と下部基板２との貼り合わせで構成されており、下部基板２の１つの面には、注入口１４を形成している片面１５と、注入口１４に注入された試料液を保持する保持チャンバー４と、分析試薬(図示せず)が保持されている試薬チャンバー５と、保持チャンバー５に保持された試料液と分析試薬とが移送され、両者を混合させるとともに分析試薬と混合された試料液の測定が行われる測定チャンバー領域７と、試薬チャンバー５と測定チャンバー領域７を連通する流路６と、測定チャンバー領域７を大気開放孔９に連通させる流路８とが形成されている。 FIG. 1 shows an analysis panel 3 of the present invention, and FIG. 2 shows an exploded view thereof.
The analysis panel 3 is formed by bonding the upper substrate 1 and the lower substrate 2, and one surface 15 forming an injection port 14 is formed on one surface of the lower substrate 2 and injected into the injection port 14. Holding chamber 4 for holding the sample solution, reagent chamber 5 for holding an analysis reagent (not shown), sample solution and analysis reagent held in the holding chamber 5 are transferred and mixed together In addition, a measurement chamber region 7 in which measurement of the sample liquid mixed with the analysis reagent is performed, a channel 6 that communicates the reagent chamber 5 and the measurement chamber region 7, and a channel that communicates the measurement chamber region 7 to the air opening hole 9. 8 are formed.

なお、この実施の形態では、試料液と分析試薬を混合させるチャンバーと、分析試薬と混合された試料液の測定が行われるチャンバーとを、一体型の測定チャンバー領域７として構成したが、試料液と分析試薬を混合させるチャンバーと、分析試薬と混合された試料液の測定が行われるチャンバーとに分かれて形成されていてもよい。   In this embodiment, the chamber in which the sample liquid and the analysis reagent are mixed and the chamber in which the measurement of the sample liquid mixed with the analysis reagent is configured as the integrated measurement chamber region 7. And a chamber in which the analysis reagent is mixed, and a chamber in which measurement of the sample liquid mixed with the analysis reagent is performed.

下部基板２に上部基板１を貼り合わせて、保持チャンバー４、試薬チャンバー５、測定チャンバー領域７、流路６および流路８の各開口面を閉塞して、所定の大きさの間隙を有する空洞が形成され、毛細管力による試料液の移送や、所定量の液量を保持するなど、それぞれの機能が働くようになっている。注入口１４は、下部基板２の片面１５と上部基板１の片面１６との接合で形成されている。   The upper substrate 1 is bonded to the lower substrate 2, the opening surfaces of the holding chamber 4, the reagent chamber 5, the measurement chamber region 7, the flow path 6 and the flow path 8 are closed, and a cavity having a predetermined size gap is formed. Each function functions such as transfer of a sample solution by capillary force and holding a predetermined amount of solution. The inlet 14 is formed by joining the one side 15 of the lower substrate 2 and the one side 16 of the upper substrate 1.

図３はこの分析用パネル３を分析装置の分析用パネル保持部材１０１に装着した状態を示している。分析装置は、ディスク状である分析用パネル保持部材１０１を、軸心１１を中心に回転駆動手段により回転させながら前記試料液の特性を光学的に分析する。   FIG. 3 shows a state in which the analysis panel 3 is mounted on the analysis panel holding member 101 of the analyzer. The analyzer optically analyzes the characteristics of the sample solution while rotating the disc-shaped analysis panel holding member 101 around the axis 11 by the rotation driving means.

図４に示すように、分析用パネル３の注入口１４は、保持チャンバー４から離れる方向に突出して形成されている。つまり、分析用パネル３を分析用パネル保持部材１０１にセットした状態における分析用パネル３の注入口１４は、分析用パネル３の本体の一側面より前記軸心１１に近づく方向に突出した形状に形成されており、試料液の供給がし易い。具体的には、人体の血液を採取して、これを試料液としてセットする場合には、採血用穿刺補助具であるランセット等の穿刺針を指先などの採血する部位に押し当て穿刺し、採血する部位に注入口１４を接触させて点着させることによって、試料液は毛細管力などにより保持チャンバー４に注入されて、容易に試料液を供給することができ、点着時に注入口１４以外の位置に血液が付着することを防ぐことができる。   As shown in FIG. 4, the inlet 14 of the analysis panel 3 is formed so as to protrude in a direction away from the holding chamber 4. That is, the inlet 14 of the analysis panel 3 in a state where the analysis panel 3 is set on the analysis panel holding member 101 has a shape protruding in a direction approaching the axis 11 from one side surface of the main body of the analysis panel 3. It is formed and it is easy to supply the sample solution. Specifically, when blood from a human body is collected and set as a sample solution, a puncture needle such as a lancet as a blood collection puncture aid is pressed against a blood collection site such as a fingertip, and blood is collected. The sample liquid is injected into the holding chamber 4 by capillary force or the like by allowing the injection port 14 to come into contact with a site to be applied, and the sample liquid can be easily supplied. It is possible to prevent blood from adhering to the position.

図５は分析装置の構成を示す。
本分析装置は、分析用パネル３が装着される分析用パネル保持部材１０１と、分析用パネル保持部材１０１を軸心１１の周りに回転駆動させる回転駆動手段としてのモータ１０２と、分析用パネル３内の溶液を光学的に測定するための光学測定手段１０４と、分析用パネル保持部材１０１の回転速度や回転方向、および光学測定手段１０４の測定タイミングなどを制御する制御手段１０５と、光学測定手段１０４によって得られた信号を処理して、試料液が血液の場合には、血液中の特定物質の濃度や量のほか、分析目的に応じて物質の形状、大きさなどを演算する演算部１０６と、演算部１０６で得られた結果を表示するための表示部１０７とで構成されている。 FIG. 5 shows the configuration of the analyzer.
This analysis apparatus includes an analysis panel holding member 101 to which the analysis panel 3 is mounted, a motor 102 as a rotation driving means for rotating the analysis panel holding member 101 around the axis 11, and the analysis panel 3. Optical measuring means 104 for optically measuring the solution in the inside, control means 105 for controlling the rotational speed and direction of the analysis panel holding member 101, the measurement timing of the optical measuring means 104, and the like, and optical measuring means When the signal obtained by 104 is processed and the sample liquid is blood, in addition to the concentration and amount of the specific substance in the blood, the calculation unit 106 calculates the shape and size of the substance according to the purpose of analysis. And a display unit 107 for displaying the result obtained by the calculation unit 106.

光学測定手段１０４には、分析用パネル３の測定部にレーザー光を照射するためのレーザー光源１０３と、レーザー光源１０３から照射されたレーザー光のうち、分析用デバイス１を通過した透過光の光量を検出するフォトディテクタ１０８とを備えており、測定に必要な波長の種類に応じたレーザー光源１０３とフォトディテクタ１０８を設けることができる。   The optical measurement means 104 includes a laser light source 103 for irradiating the measurement unit of the analysis panel 3 with laser light, and the amount of transmitted light that has passed through the analysis device 1 out of the laser light emitted from the laser light source 103. And a laser light source 103 and a photodetector 108 corresponding to the type of wavelength required for the measurement can be provided.

この分析装置は、その用途に応じて、分析用パネル３内のチャンバー及び流路の構成により、軸心周りの回転によって発生する遠心力を用いて、パネル内の液を移送したり、遠心分離したりする遠心分離機にもなりえる。分析用パネルの形状は、扇形状や、立方体形状やその他の形状のものでもよく、又、これらの分析用パネル３を複数個同時に、分析用パネル保持部材１０１へ装着してもかまわない。   Depending on the application, this analyzer uses the centrifugal force generated by the rotation around the axial center depending on the configuration of the chamber and flow path in the analysis panel 3 to transfer the liquid in the panel or perform centrifugation. It can also be a centrifuge. The shape of the analysis panel may be a fan shape, a cube shape, or other shapes, and a plurality of these analysis panels 3 may be mounted on the analysis panel holding member 101 simultaneously.

注入口１４の周辺部の拡大を示す図４のように、分析用パネル３の一側面で注入口１４の周囲には、前記軸心１１の側のみが開口し、さらに軸心１１より外周方向に向けて窪んだ凹部１２が形成されている。凹部１２は、軸心１１の側における開口部の断面積が、凹部１２の外周側の開口部における断面積の同等以上の大きさになるように、ゆるやかに湾曲した形状に形成したため、図３に示した状態で遠心力が発生すると、注入口１４の周囲に付着した試料液は、確実に凹部１２へ移送され、さらに凹部１２の一番低い位置へ移送されやすくなり、凹部１２の外へ飛散することなく、収集できる。   As shown in FIG. 4 showing the enlargement of the peripheral portion of the inlet 14, only the side of the axis 11 is opened around the inlet 14 on one side of the analysis panel 3, and the outer peripheral direction from the axis 11. A concave portion 12 that is recessed toward is formed. The recess 12 is formed in a gently curved shape so that the cross-sectional area of the opening on the side of the axis 11 is equal to or larger than the cross-sectional area of the opening on the outer peripheral side of the recess 12. When the centrifugal force is generated in the state shown in FIG. 4, the sample liquid adhering to the periphery of the inlet 14 is surely transferred to the concave portion 12 and further easily transferred to the lowest position of the concave portion 12 and out of the concave portion 12. Can be collected without splashing.

また、この開口されている凹部１２の底面から軸心１１に近づく方向に突出するように、前記片面１５，１６によって注入口１４の突起状に形成したことによって、注入口１４の周囲に付着した試料液は、凹部１２内へ移送されるのであるが、移送されたその位置は、凹部１２内のほぼ底面なので、試料液は凹部１２内から溢れ出すことはなく安定して収集でき、また、１つの凹部１２で収集できるという効果も得られる。   In addition, the projections of the injection port 14 are formed by the one surfaces 15 and 16 so as to protrude in the direction approaching the axis 11 from the bottom surface of the opened recess 12, so that they adhere to the periphery of the injection port 14. Although the sample liquid is transferred into the recess 12, the transferred position is almost the bottom surface in the recess 12, so that the sample liquid can be stably collected without overflowing from the recess 12, The effect that it can collect with one recessed part 12 is also acquired.

つまり、注入口１４の近傍に付着した試料液は、軸心回りの回転により発生する遠心力によって、注入口１４を形成している突起部の表面を伝わって、凹部１２内へ移送されるのである。またこのとき、保持チャンバー４内の試料液は、注入口１４の近傍に付着した試料液の凹部１２内への移送と同時に、遠心力によって、分析試薬があらかじめ担持されている試薬チャンバー５内に移送される。試薬チャンバー５内に流入した液試料は、分析用パネル保持部材１０１の回転の加速度による揺動や回転停止中の液の拡散によって、試薬チャンバー５内に担持されている分析試薬と混合されるが、試薬チャンバー５自体を直接振動させるような外的な力を作用させて混合することも可能である。   In other words, the sample liquid adhering to the vicinity of the injection port 14 is transferred into the recess 12 through the surface of the protruding portion forming the injection port 14 by the centrifugal force generated by the rotation around the axis. is there. At this time, the sample solution in the holding chamber 4 is transferred into the reagent chamber 5 in which the analysis reagent is previously supported by centrifugal force simultaneously with the transfer of the sample solution adhering to the vicinity of the inlet 14 into the recess 12. Be transported. The liquid sample that has flowed into the reagent chamber 5 is mixed with the analysis reagent carried in the reagent chamber 5 by swinging due to the rotation acceleration of the analysis panel holding member 101 or diffusion of the liquid while the rotation is stopped. It is also possible to mix by applying an external force that directly vibrates the reagent chamber 5 itself.

分析試薬と試料液との混合が所定のレベルに到達すると、試薬チャンバー５内の試料液は、毛細管力で流路６内を通じて、測定チャンバー領域７の入口まで移送される。測定チャンバー領域７をレーザー光源１０３から照射したレーザー光が通過し、試料液と分析試薬との反応状態をフォトディテクタ１０８で吸光度測定することにより、その成分の濃度を測定することができる。   When the mixing of the analysis reagent and the sample solution reaches a predetermined level, the sample solution in the reagent chamber 5 is transferred to the entrance of the measurement chamber region 7 through the channel 6 by capillary force. The laser beam irradiated from the laser light source 103 passes through the measurement chamber region 7 and the concentration of the component can be measured by measuring the absorbance of the reaction state between the sample liquid and the analysis reagent with the photodetector 108.

なお、凹部１２の容積は、試料液の注入口１４への点着時に注入口１４の近傍に付着した試料液を受容できる大きさにしたことで、試料液が凹部１２内から溢れ出すほどの容積が移送されることを防止する効果がある。試料液として血液が適用されることを想定し、ランセット等の穿刺装置を用いての指先採血による点着のような場合には、試料液の量はおよそ１０μｌ程度と推測し、この点着量を超えない範囲の採血量を注入口１４から注入するのが一般的であるため、凹部１２の容積を、最大で１０μｌに設定している。   The volume of the recess 12 is set to a size that can accept the sample solution adhering to the vicinity of the injection port 14 when the sample solution is spotted on the injection port 14, so that the sample solution overflows from the recess 12. This has the effect of preventing the volume from being transferred. Assuming that blood is applied as the sample liquid, in the case of spotting by fingertip blood collection using a puncture device such as a lancet, the amount of the sample liquid is estimated to be about 10 μl, and this spotting quantity Since the amount of blood collected in a range not exceeding 1 is generally injected from the inlet 14, the volume of the recess 12 is set to 10 μl at the maximum.

さらに、図６に示されるように、注入口１４と凹部１２とを覆う開閉可能なカバー１８を分析用パネル３に設けることによって、更に、次のような効果が得られる。
前記カバー１８を開けて注入口１４へ試料液を点着し、その後にカバー１８を閉じた状態で分析用パネル３を分析用パネル保持部材１０１に装着することによって、凹部１２へ移送されてきた試料液やチャンバー４内へ移送された試料液が、何らかの影響で注入口１４及び凹部１２の付近の分析用パネル３の側面に流出しても、カバー１８で受け止めて外部へ放出される事態の発生を防止できる。また、分析後もカバー１８を開放させることなくそのまま使い捨てすることによって、汚染の発生を防止することができ、使い捨ての分析用パネルに適している。 Furthermore, as shown in FIG. 6, by providing the analysis panel 3 with an openable / closable cover 18 that covers the inlet 14 and the recess 12, the following effects can be obtained.
The cover 18 is opened, the sample solution is spotted on the inlet 14, and then the analysis panel 3 is mounted on the analysis panel holding member 101 in a state where the cover 18 is closed. Even if the sample liquid or the sample liquid transferred into the chamber 4 flows out to the side surface of the analysis panel 3 near the inlet 14 and the recess 12 due to some influence, it is received by the cover 18 and released to the outside. Occurrence can be prevented. In addition, after the analysis, by disposing the cover 18 without opening it, the occurrence of contamination can be prevented, which is suitable for a disposable analysis panel.

また、注入口１４の周縁部の表面に界面活性剤を塗布した場合には、前記遠心力による試料液の凹部１２への移送時に、試料液が注入口１４の周縁部の表面における界面活性剤の親水性処理によって、スムーズに移送させることができる。   Further, when a surfactant is applied to the peripheral surface of the inlet 14, the sample liquid is transferred to the peripheral surface of the inlet 14 when the sample liquid is transferred to the recess 12 by the centrifugal force. By the hydrophilic treatment, it can be smoothly transferred.

このように、注入口１４の周囲に凹部１２を形成したため、注入口１４の近傍に付着した試料液が飛散して汚染されるようなことなく分析することができ、さらに、チャンバー４内に注入された試料液がチャンバー外に逆方向に放出されるのを防止するという効果が得られる。   As described above, since the concave portion 12 is formed around the inlet 14, the sample liquid adhering to the vicinity of the inlet 14 can be analyzed without being scattered and contaminated, and further injected into the chamber 4. An effect of preventing the sample liquid that has been discharged from being discharged in the reverse direction outside the chamber can be obtained.

（実施の形態２）
図７と図８は本発明の実施の形態２を示す。
なお、分析用パネル３の主な構成、および分析用パネル３が装着される分析用パネル保持部材１０１、また試料液と分析試薬との反応状態の測定方法については実施の形態１で説明した内容と同じであるため、ここでの説明は省略する。 (Embodiment 2)
7 and 8 show a second embodiment of the present invention.
The main configuration of the analysis panel 3, the analysis panel holding member 101 to which the analysis panel 3 is mounted, and the method for measuring the reaction state between the sample solution and the analysis reagent are the same as those described in the first embodiment. Since this is the same, the description here is omitted.

図７は、実施の形態２における分析用パネル３の注入口１４の近傍の構成を示す。
注入口１４の先端は、分析用パネル３の本体の一側面とほぼ同等な位置にあって、注入口１４の周囲には、前記軸心１１の側の面のみが開口し、かつ軸心１１より外周方向に向けて窪む凹部１２が形成されている。さらに凹部１２は、凹部１２の軸心１１の側における開口部の断面積は、凹部１２の外周側の開口部における断面積よりも同等以上の大きさで形成されている。また注入口１４は、凹部１２の底面から突出して形成しており、凹部１２の容積は、試料液の注入口１４への点着時に、注入口近傍に付着した試料液滴を受容できる大きさで構成されている。ここでランセット等の穿刺装置を用いて一回の指先採血で点着できる量は、１０μｌ程度が限界であり、その点着量を超えない範囲の採血量を注入口１４から注入するのが一般的である。その考えをベースに本発明では凹部１２の容量を、最大で１０μｌに設定している。 FIG. 7 shows a configuration in the vicinity of the inlet 14 of the analysis panel 3 in the second embodiment.
The tip of the inlet 14 is located at a position substantially equivalent to one side surface of the main body of the analysis panel 3, and only the surface on the axis 11 side opens around the inlet 14. A recess 12 that is recessed toward the outer peripheral direction is formed. Further, the recess 12 is formed so that the cross-sectional area of the opening on the axis 11 side of the recess 12 is equal to or larger than the cross-sectional area of the opening on the outer peripheral side of the recess 12. The inlet 14 is formed so as to protrude from the bottom surface of the recess 12, and the volume of the recess 12 is large enough to accept a sample droplet adhering to the vicinity of the inlet when the sample liquid is spotted on the inlet 14. It consists of Here, the amount that can be spotted by one fingertip blood collection using a puncture device such as a lancet is limited to about 10 μl, and it is common to inject a blood collection volume within a range not exceeding the amount of spotting from the injection port 14. Is. Based on this idea, the capacity of the recess 12 is set to 10 μl at the maximum in the present invention.

さらに凹部１２には、試料液を吸収する材料として、例えばポリプロピレンや紙材料で構成された不織布等の吸収部材２２が設けられている。
このように構成したため、試料液を注入口１４に点着して試料液を供給した状態では、図８（ａ）に示すように注入口１４の近傍には試料液滴１９が付着している。試料液滴１９が付着した分析用パネル３をそのまま分析用パネル保持部材１０１に取り付け、軸心１１回りに回転させることにより発生する遠心力によって、注入口１４の付近に付着した試料液滴は凹部１２内を矢印２０の方向に移動させられ、吸収部材２２まで移送され、最終的には吸収部材２２に吸引される。 Further, the recess 12 is provided with an absorbing member 22 such as a nonwoven fabric made of polypropylene or paper material as a material that absorbs the sample liquid.
With this configuration, when the sample liquid is spotted on the inlet 14 and the sample liquid is supplied, the sample droplet 19 is attached in the vicinity of the inlet 14 as shown in FIG. . The analysis panel 3 to which the sample droplet 19 is attached is attached to the analysis panel holding member 101 as it is, and the sample droplet adhering to the vicinity of the inlet 14 is recessed by the centrifugal force generated by rotating around the axis 11. 12 is moved in the direction of the arrow 20, transferred to the absorption member 22, and finally sucked by the absorption member 22.

試料液を吸収する吸収部材２２を配置した状態で、パネル本体内部での試料液の移送に使う所定の遠心力の作用をそのまま利用することによって、注入口近傍に付着した試料液を凹部１２へ移送させ、さらに、注入口より外周側に設けられた吸収部材２２が、移送されてきた注入口近傍に付着した試料液を、吸収して収集できるので、吸収部材２２がない場合よりも、より収集する効果が高くできる効果がある。   In the state where the absorbing member 22 that absorbs the sample liquid is disposed, the sample liquid adhering to the vicinity of the inlet is transferred to the recess 12 by directly using the action of a predetermined centrifugal force used for transferring the sample liquid inside the panel body. Furthermore, the absorption member 22 provided on the outer peripheral side of the injection port can absorb and collect the sample liquid adhering to the vicinity of the injection port that has been transferred. There is an effect that the effect of collecting can be increased.

分析用パネル３に所定量の試料液を注入後、分析用パネル保持部材１０１に取り付け、試料液滴を移送するのに必要な回転数は、１０００ｒｐｍ以上が必要であるが、凹部１２の内周全面および注入口１４の近傍に界面活性剤等で親水性処理を行った場合は、数百ｒｐｍの回転による遠心力を作用させるだけで、試料液滴を移送させることも可能である。   After injecting a predetermined amount of the sample liquid into the analysis panel 3, it is attached to the analysis panel holding member 101, and the number of rotations necessary for transferring the sample droplet is 1000 rpm or more. When hydrophilic treatment is performed on the entire surface and the vicinity of the injection port 14 with a surfactant or the like, the sample droplet can be transferred only by applying a centrifugal force by rotation of several hundred rpm.

また、吸収部材２２は凹部１２の底面に備え付けてもよいし、注入口１４と凹部１２の底面との間に設けてもよい。
また、吸収部材２２を設けたことによって、吸収部材２２に一旦保持した試料液滴１９は、分析終了後に吸収部材２２を重力が作用する方向に傾けても、吸収部材２２の外へ漏れ出しを防止できる効果がある。 Further, the absorbing member 22 may be provided on the bottom surface of the recess 12, or may be provided between the inlet 14 and the bottom surface of the recess 12.
Further, by providing the absorbing member 22, the sample droplet 19 once held on the absorbing member 22 leaks out of the absorbing member 22 even if the absorbing member 22 is tilted in the direction in which gravity acts after the analysis is completed. There is an effect that can be prevented.

さらに、実施の形態１の場合と同様に前記カバー１８を分析用パネル３に設け、カバー１８を開けて注入口１４へ試料液を点着し、その後にカバー１８を閉じた状態で分析用パネル３を分析用パネル保持部材１０１に装着することによって、試料液の流出防止に対する信頼性がより向上する。   Further, as in the case of the first embodiment, the cover 18 is provided on the analysis panel 3, the cover 18 is opened, the sample liquid is spotted on the inlet 14, and then the analysis panel is closed. By mounting 3 on the analysis panel holding member 101, the reliability of preventing the sample liquid from flowing out is further improved.

（実施の形態３）
図９と図１０は本発明の実施の形態３を示す。
実施の形態２では凹部１２内の底面、または注入口１４と凹部１２内の底面との間に吸収部材２２を設けたが、この実施の形態３では凹部１２に連通する溝部１７を設け、毛細管力により試料液滴１９を保持するように構成した点だけが異なり、その他は実施の形態２と同じである。 (Embodiment 3)
9 and 10 show Embodiment 3 of the present invention.
In the second embodiment, the absorbing member 22 is provided between the bottom surface in the concave portion 12 or between the inlet 14 and the bottom surface in the concave portion 12, but in the third embodiment, the groove portion 17 communicating with the concave portion 12 is provided, and the capillary tube is provided. The only difference is that the sample droplet 19 is held by force, and the rest is the same as in the second embodiment.

図９は実施の形態３における分析用パネル３の注入口１４の近傍を示す。
注入口１４の先端は、分析用パネル３の本体の一側面とほぼ同等な位置にあって、注入口１４の周囲には、前記軸心１１の側の面のみが開口し、軸心１１より外周方向に向けて窪む凹部１２が形成されている。さらに凹部１２は、凹部１２の軸心１１の側における開口部の断面積は、凹部１２の外周側の開口部における断面積よりも同等以上の大きさで形成されている。また注入口１４は、凹部１２の底面から突出して形成しており、凹部１２の容積は、試料液の注入口１４への点着時に、注入口近傍に付着した試料液滴を受容できる大きさで構成されている。凹部１２の底面には、凹部１２に連通する一つ以上の溝部１７が形成されている。 FIG. 9 shows the vicinity of the inlet 14 of the analysis panel 3 in the third embodiment.
The tip of the inlet 14 is located at a position substantially equivalent to one side surface of the main body of the analysis panel 3, and only the surface on the axis 11 side opens around the inlet 14. A recess 12 that is recessed toward the outer circumferential direction is formed. Further, the recess 12 is formed so that the cross-sectional area of the opening on the axis 11 side of the recess 12 is equal to or larger than the cross-sectional area of the opening on the outer peripheral side of the recess 12. The inlet 14 is formed so as to protrude from the bottom surface of the recess 12, and the volume of the recess 12 is large enough to accept a sample droplet adhering to the vicinity of the inlet when the sample liquid is spotted on the inlet 14. It consists of On the bottom surface of the recess 12, one or more groove portions 17 communicating with the recess 12 are formed.

このように構成したため、試料液を注入口１４に点着して試料液を供給した状態では、図１０（ａ）に示すように注入口１４の近傍には試料液滴１９が付着している。試料液滴１９が付着した分析用パネル３をそのまま分析用パネル保持部材１０１に取り付け、軸心１１の回りに回転させることにより発生する遠心力によって、注入口１４の付近に付着した試料液滴は、図１０（ｂ）に示すように凹部１２内を矢印２０の方向に移動させられ、凹部１２内の溝部１７の手前の位置まで移送され、最終的には図１０（ｃ）に示すように溝部１７の内部にまで移送され、そこで収集される。   With this configuration, when the sample liquid is spotted on the inlet 14 and the sample liquid is supplied, the sample droplet 19 is attached in the vicinity of the inlet 14 as shown in FIG. . A sample droplet adhering to the vicinity of the inlet 14 due to a centrifugal force generated by attaching the analysis panel 3 to which the sample droplet 19 is attached to the analysis panel holding member 101 as it is and rotating it around the axis 11 is 10 (b), the concave portion 12 is moved in the direction of the arrow 20 and transferred to a position in front of the groove portion 17 in the concave portion 12, and finally, as shown in FIG. 10 (c). It is transferred to the inside of the groove 17 and collected there.

つまり、凹部１２に連続して溝部１７を設けたことにより、凹部１２へ移送されてきた試料液滴１９は、遠心力により更に溝部１７の内部へ移送されて溝部１７の内部においてで毛細管力により保持される。毛細管力により保持されているので、その後の遠心力がない状態でも、試料液が外部へ溢れ出すことを防止できる効果が得られる。   That is, by providing the groove portion 17 continuously to the concave portion 12, the sample droplet 19 transferred to the concave portion 12 is further transferred to the inside of the groove portion 17 by centrifugal force, and by the capillary force inside the groove portion 17. Retained. Since it is held by capillary force, the effect of preventing the sample liquid from overflowing to the outside can be obtained even in the absence of subsequent centrifugal force.

このように、試料液の移送に使う所定の遠心力の作用をそのまま利用することによって、試料液滴１９が溝部１７に確実に集められるので、試料液が分析用パネル３の外に飛散するのを防ぐため、汚染されることなく分析できる。   In this way, by using the action of the predetermined centrifugal force used for transferring the sample solution as it is, the sample droplet 19 is reliably collected in the groove portion 17, so that the sample solution is scattered outside the analysis panel 3. Can be analyzed without contamination.

また、溝部１７を、凹部１２である試料受容部の最も外周側における底部に形成したことにより、凹部１２へ移送されてきた試料液滴１９を、注入口１４からより離れた位置ですべて捕集できる効果がある。   Further, since the groove portion 17 is formed at the bottom of the sample receiving portion which is the concave portion 12 on the outermost peripheral side, all the sample droplets 19 transferred to the concave portion 12 are collected at a position farther from the injection port 14. There is an effect that can be done.

また、この実施の形態３における溝部１７の断面形状は長方形状にしてあるが、別段、円形や三角形や多角形などの他の形状でもよい。何れの場合も、分析用パネル３が分析終了後、分析用パネル保持部材１０１から取り外されて重力方向に傾けられても、溝部１７内の試料液が落下しないようにするために、溝部１７の軸心１１の側の開口部２１の厚みｄが１ｍｍ以下に形成されている。   Moreover, although the cross-sectional shape of the groove part 17 in this Embodiment 3 is made into the rectangular shape, other shapes, such as a round shape, a triangle, and a polygon, may be sufficient. In any case, even if the analysis panel 3 is removed from the analysis panel holding member 101 and tilted in the direction of gravity after the analysis is completed, the groove 17 A thickness d of the opening 21 on the side of the axis 11 is formed to be 1 mm or less.

さらに、実施の形態１の場合と同様に前記カバー１８を分析用パネル３に設け、カバー１８を開けて注入口１４へ試料液を点着し、その後にカバー１８を閉じた状態で分析用パネル３を分析用パネル保持部材１０１に装着することによって、試料液の流出防止に対する信頼性がより向上する。つまり、凹部１２へ移送されてきた試料液やチャンバー内へ移送された試料液が、何らかの影響で注入口１４や凹部１２から分析用パネル３の側面に流出しても、カバー１８で受け止めて外部へ放出される事態の発生を防止できる。また、分析後もカバー１８を開放させることなくそのまま使い捨てすることによって、汚染の発生を防止することができ、使い捨ての分析用パネルに適している。   Further, as in the case of the first embodiment, the cover 18 is provided on the analysis panel 3, the cover 18 is opened, the sample liquid is spotted on the inlet 14, and then the analysis panel is closed. By mounting 3 on the analysis panel holding member 101, the reliability of preventing the sample liquid from flowing out is further improved. That is, even if the sample liquid transferred to the concave portion 12 or the sample liquid transferred into the chamber flows out of the inlet 14 or the concave portion 12 to the side surface of the analysis panel 3 due to some influence, it is received by the cover 18 and externally received. Occurrence of a situation where it is released to In addition, after the analysis, by disposing the cover 18 without opening it, the occurrence of contamination can be prevented, which is suitable for a disposable analysis panel.

（実施の形態４）
図１１と図１２は本発明の実施の形態４を示す。
実施の形態３では溝部１７は端部が閉塞していたが、この実施の形態４では通路としての溝部１７が試薬チャンバー５に連通するように構成した点だけが異なり、その他は実施の形態３と同じである。 (Embodiment 4)
11 and 12 show a fourth embodiment of the present invention.
In the third embodiment, the end of the groove portion 17 is closed. However, the fourth embodiment is different from the third embodiment only in that the groove portion 17 as a passage communicates with the reagent chamber 5. Is the same.

図１１は実施の形態４における分析用パネル３の注入口１４の近傍を示す。
保持チャンバー４を介して試薬チャンバー５に連通している注入口１４の先端は、分析用パネル３の本体の一側面とほぼ同等な位置にあって、注入口１４の周囲には、前記軸心１１の側の面のみが開口し、かつ、軸心１１より外周方向に向けて窪む凹部１２が形成されている。さらに凹部１２は、凹部１２の軸心１１の側における開口部の断面積は、凹部１２の外周側の開口部における断面積よりも同等以上の大きさで形成されている。 FIG. 11 shows the vicinity of the inlet 14 of the analysis panel 3 in the fourth embodiment.
The tip of the injection port 14 communicating with the reagent chamber 5 via the holding chamber 4 is located at a position substantially equivalent to one side surface of the main body of the analysis panel 3. Only the surface on the 11 side is open, and a recess 12 that is recessed from the shaft 11 toward the outer periphery is formed. Further, the recess 12 is formed so that the cross-sectional area of the opening on the axis 11 side of the recess 12 is equal to or larger than the cross-sectional area of the opening on the outer peripheral side of the recess 12.

また、注入口１４は凹部１２の底面から突出して形成しており、凹部１２の容積は、試料液の注入口１４への点着時に、注入口近傍に付着した試料液滴を受容できる大きさで構成されている。   Further, the injection port 14 is formed so as to protrude from the bottom surface of the recess 12, and the volume of the recess 12 is large enough to accept a sample droplet adhering to the vicinity of the injection port when the sample liquid is spotted on the injection port 14. It consists of

また、凹部１２の底面は試薬チャンバー５に連通している。詳しくは、凹部１２の底面には、一端が凹部１２に連通する一つ以上の溝部１７が形成されており、溝部１７の他端（外周方向の端部）が試薬チャンバー５に連通している。   In addition, the bottom surface of the recess 12 communicates with the reagent chamber 5. Specifically, one or more grooves 17 having one end communicating with the recess 12 are formed on the bottom surface of the recess 12, and the other end (end in the outer circumferential direction) of the groove 17 communicates with the reagent chamber 5. .

なお、この実施の形態４では、各溝部１７の他端は、注入口１４の外周側で互いに連通してから試薬チャンバー５に連通しているが、試薬チャンバー５に別々に連通していてもよい。   In the fourth embodiment, the other end of each groove portion 17 communicates with the reagent chamber 5 after communicating with the outer peripheral side of the injection port 14, but may communicate with the reagent chamber 5 separately. Good.

このように構成したため、試料液を注入口１４に点着して試料液を供給した状態では、図１２（ａ）に示すように注入口１４の近傍には試料液滴１９が付着している。試料液滴１９が付着した分析用パネル３をそのまま分析用パネル保持部材１０１に取り付け、軸心１１の回りに回転させることにより発生する遠心力によって、注入口１４の付近に付着した試料液滴は、図１２（ｂ）に示すように凹部１２内を矢印２０の方向に移動させられ、凹部１２内の溝部１７の手前の位置まで移送され、最終的には図１２（ｃ）に示すように試薬チャンバー５の内部にまで移送され、そこで収集される。   With this configuration, when the sample liquid is spotted on the inlet 14 and the sample liquid is supplied, the sample droplet 19 is attached in the vicinity of the inlet 14 as shown in FIG. . A sample droplet adhering to the vicinity of the inlet 14 due to a centrifugal force generated by attaching the analysis panel 3 to which the sample droplet 19 is attached to the analysis panel holding member 101 as it is and rotating it around the axis 11 is 12 (b), it is moved in the direction of the arrow 20 in the recess 12 and transferred to a position in front of the groove portion 17 in the recess 12, and finally as shown in FIG. 12 (c). It is transferred to the inside of the reagent chamber 5 and collected there.

つまり、凹部１２に連続して溝部１７を設けたことにより、凹部１２へ移送されてきた試料液滴１９は、遠心力により更に溝部１７の内部へ移送されて溝部１７の内部においてで毛細管力により保持され、さらに遠心力により試薬チャンバー５の内部で試料液が保持されるので、その後の遠心力がない状態でも、試料液が外部へ溢れ出すことを防止できる効果が得られる。   That is, by providing the groove portion 17 continuously to the concave portion 12, the sample droplet 19 transferred to the concave portion 12 is further transferred to the inside of the groove portion 17 by centrifugal force, and by the capillary force inside the groove portion 17. Since the sample liquid is held inside the reagent chamber 5 by the centrifugal force, it is possible to prevent the sample liquid from overflowing to the outside even in the absence of the subsequent centrifugal force.

このように、注入口１４の近傍に付着した試料液滴１９が、試料液の移送に使う所定の遠心力の作用をそのまま利用して試薬チャンバー５に確実に集められるので、試料液が飛散して汚染されるようなことなく、安全に試料液中の成分の分析が可能になる。さらに、注入口１４の周囲に付着した試料液を無駄にしないで、分析用の試料液として有効に活用できるという効果がある。これは、近年、市場からの要求である、試料分析中の試料液の少量化の要求において、容量的に不足になりがちな試料液に対して、同一の試料液で補充できるという点で、非常にメリットがある。   In this way, the sample droplet 19 attached in the vicinity of the inlet 14 is reliably collected in the reagent chamber 5 using the action of a predetermined centrifugal force used for transferring the sample solution as it is, so that the sample solution is scattered. This makes it possible to safely analyze the components in the sample solution without being contaminated. Furthermore, there is an effect that the sample liquid adhering to the periphery of the inlet 14 can be effectively used as a sample liquid for analysis without wasting it. This is because the same sample liquid can be replenished with respect to the sample liquid that tends to be insufficient in volume in recent years, which is a demand from the market, which is a demand for a small amount of sample liquid during sample analysis. Very beneficial.

また、溝部１７を凹部１２と試薬チャンバー５の間に形成されたことにより、凹部１２へ移送されてきた試料液を、注入口１４からより離れた位置で、溝部１７へ余すところなく移送できる効果がある。   Further, since the groove portion 17 is formed between the concave portion 12 and the reagent chamber 5, the sample liquid transferred to the concave portion 12 can be transferred to the groove portion 17 at a position farther from the inlet 14. There is.

また、この実施の形態４における溝部１７の断面形状は長方形状にしてあるが、別段、円形や三角形や多角形などの他の形状でもよい。何れの場合も、分析用パネル３が分析終了後、分析用パネル保持部材１０１から取り外されて重力方向に傾けられても、溝部１７内の試料液が落下しないようにするために、溝部１７の軸心１１の側の開口部２１の厚みｄが１ｍｍ以下の大きさで形成されている。   Moreover, although the cross-sectional shape of the groove part 17 in this Embodiment 4 is made into the rectangular shape, other shapes, such as a round shape, a triangle, and a polygon, may be sufficient. In any case, even if the analysis panel 3 is removed from the analysis panel holding member 101 and tilted in the direction of gravity after the analysis is completed, the groove 17 A thickness d of the opening 21 on the side of the shaft center 11 is formed with a size of 1 mm or less.

さらに、実施の形態１の場合と同様に前記カバー１８を分析用パネル３に設け、カバー１８を開けて注入口１４へ試料液を点着し、その後にカバー１８を閉じた状態で分析用パネル３を分析用パネル保持部材１０１に装着することによって、試料液の流出防止に対する信頼性がより向上する。つまり、凹部１２へ移送されてきた試料液やチャンバー内へ移送された試料液が、何らかの影響で注入口１４や凹部１２から分析用パネル３の側面に流出しても、カバー１８で受け止めて外部へ放出される事態の発生を防止できる。また、分析後もカバー１８を開放させることなくそのまま使い捨てすることによって、汚染の発生を防止することができ、使い捨ての分析用パネルに適している。   Further, as in the case of the first embodiment, the cover 18 is provided on the analysis panel 3, the cover 18 is opened, the sample liquid is spotted on the inlet 14, and then the analysis panel is closed. By mounting 3 on the analysis panel holding member 101, the reliability of preventing the sample liquid from flowing out is further improved. That is, even if the sample liquid transferred to the concave portion 12 or the sample liquid transferred into the chamber flows out of the inlet 14 or the concave portion 12 to the side surface of the analysis panel 3 due to some influence, it is received by the cover 18 and externally received. Occurrence of a situation where it is released to In addition, after the analysis, by disposing the cover 18 without opening it, the occurrence of contamination can be prevented, which is suitable for a disposable analysis panel.

（実施の形態５）
図１３〜図１５は本発明の実施の形態５を示す。
上記の各実施の形態においては、分析用パネル保持部材１０１への分析用パネル３のセット状態が、分析用パネル保持部材１０１の前記軸心１１よりも外周側に分析用パネル３の全体が配置されていたが、この実施の形態５では図１５に示すように、分析用パネル３の一部が、分析用パネル保持部材１０１の前記軸心１１を横切って反対側に突出している。 (Embodiment 5)
13 to 15 show a fifth embodiment of the present invention.
In each of the embodiments described above, the analysis panel 3 is set on the analysis panel holding member 101 so that the entire analysis panel 3 is arranged on the outer peripheral side of the axis 11 of the analysis panel holding member 101. However, in the fifth embodiment, as shown in FIG. 15, a part of the analysis panel 3 protrudes to the opposite side across the axis 11 of the analysis panel holding member 101.

この実施の形態で使用する分析用パネル３は、図１３に示すように実施の形態１〜実施の形態４の何れかにおける分析用パネル３のうちでも、前記カバー１８の付いたものを採用している。   As the analysis panel 3 used in this embodiment, the panel with the cover 18 is adopted among the analysis panels 3 in any of the first to fourth embodiments as shown in FIG. ing.

図１４と図１５は、カバー１８を有する分析用パネル３を分析用パネル保持部材１０１にセットする前後の様子を示しており、分析用パネル保持部材１０１における分析用パネル３の装着の位置が実施の形態１〜実施の形態４のそれとは異なっている。   14 and 15 show the state before and after the analysis panel 3 having the cover 18 is set on the analysis panel holding member 101, and the mounting position of the analysis panel 3 on the analysis panel holding member 101 is implemented. This is different from that of the first to fourth embodiments.

具体的には、実施の形態１〜実施の形態４では分析用パネル３が、分析用パネル保持部材１０１の軸心１１よりも外周側に装着されていたが、この実施の形態５では、分析用パネル３の注入口１４が分析用パネル保持部材１０１の軸心１１を横切るように装着されている。また、必要に応じて図１５に示すように、前記カバー１８内側に、カバー１８を閉じた状態で注入口１４に対向する位置に、空隙２４をあけて吸収部材２２が配置されている。   Specifically, in the first to fourth embodiments, the analysis panel 3 is mounted on the outer peripheral side of the axis 11 of the analysis panel holding member 101. In the fifth embodiment, the analysis panel 3 is analyzed. The injection port 14 of the panel 3 is mounted so as to cross the axis 11 of the analysis panel holding member 101. Further, as shown in FIG. 15, if necessary, an absorbing member 22 is disposed inside the cover 18 at a position facing the inlet 14 with the cover 18 closed, with a gap 24 therebetween.

このように構成したため、所定量の試料液を注入口１４から注入してカバー１８を閉じた状態の分析用パネル３を分析用パネル保持部材１０１に装着してモータ１０２を回転駆動すると、保持チャンバー４にある試料液はこれまでの実施の形態と同様に、軸心１１から試薬チャンバー５の側に向かって矢印２５方向に移動する。一方、注入口１４の近傍に付着していた試料液滴１９は、遠心力によって矢印２６の方向に移動させられ、カバー１８に捕集される。前記吸収部材２２がカバー１８内側に設けられている場合には吸収部材２２まで移送され、最終的には吸収部材２２に吸引される。つまり、注入口１４の近傍に付着した試料液滴１９は、カバー１８を閉めることで、カバー内で遮断し外部へ放出されるのを防止できる構造になっており、分析後もカバーを開放させることなく、汚染することなく、そのまま使い捨てが可能な使い捨ての分析用パネル向けに適するという効果がある。   With this configuration, when a predetermined amount of sample liquid is injected from the inlet 14 and the analysis panel 3 with the cover 18 closed is attached to the analysis panel holding member 101 and the motor 102 is driven to rotate, the holding chamber The sample solution in 4 moves in the direction of the arrow 25 from the axis 11 toward the reagent chamber 5 as in the previous embodiments. On the other hand, the sample droplet 19 adhering to the vicinity of the injection port 14 is moved in the direction of the arrow 26 by the centrifugal force and collected by the cover 18. When the absorbing member 22 is provided inside the cover 18, the absorbing member 22 is transferred to the absorbing member 22 and finally sucked by the absorbing member 22. That is, the sample droplet 19 adhering to the vicinity of the inlet 14 has a structure in which the cover 18 can be closed and prevented from being released to the outside by closing the cover 18, and the cover is opened even after analysis. Without being contaminated, there is an effect that it is suitable for a disposable analytical panel that can be disposable as it is.

吸収部材２２は、例えばポリプロピレンや紙材料で構成された不織布等を使用できる。この吸収部材２２の大きさは、前記注入口１４の近傍に付着した試料液を受容できる大きさであればよい。   For example, the absorbent member 22 may be a nonwoven fabric made of polypropylene or paper material. The absorbent member 22 may be of any size as long as it can receive the sample liquid adhering to the vicinity of the inlet 14.

このように、分析用パネル３の保持チャンバー４にある試料液を試薬チャンバー５以降への移送に使う遠心力の作用をそのまま利用することによって、注入口１４の近傍に付着した試料液滴１９をカバー１８の内部に確実に収集できる。   As described above, the sample liquid 19 in the holding chamber 4 of the analysis panel 3 is used as it is to transfer the sample liquid 19 attached to the vicinity of the inlet 14 by using the centrifugal force used for transferring the sample liquid to the reagent chamber 5 and the subsequent ones. It can be reliably collected inside the cover 18.

（実施の形態６）
図１６〜図１９は本発明の実施の形態６を示す。
カバー１８を有する分析用パネル３を分析用パネル保持部材１０１に装着した時の軸心１１と分析用パネル３との位置関係は実施の形態４と同じであるが、この実施の形態６ではカバー１８の内側に凹部２３が設けられている。 (Embodiment 6)
16 to 19 show a sixth embodiment of the present invention.
The positional relationship between the axial center 11 and the analysis panel 3 when the analysis panel 3 having the cover 18 is attached to the analysis panel holding member 101 is the same as that in the fourth embodiment. A recess 23 is provided inside 18.

図１７と図１８に示すようにカバー１８を閉じた状態において、分析用パネル３の注入口１４はカバー１８の底部から距離２７だけ離れた位置に設定して、カバー１８の底部に注入口１４が接触しない方が望ましい。カバー１８の底部から注入口１４の側に向かって突出して注入口１４の外側と距離をおいて取り囲む凹部２３の突出量２８は、注入口１４の先端が凹部２３の開口から内側に入り込むように設定されている。   17 and 18, with the cover 18 closed, the inlet 14 of the analysis panel 3 is set at a position away from the bottom of the cover 18 by a distance 27, and the inlet 14 is formed at the bottom of the cover 18. It is better not to touch. The amount of protrusion 28 of the recess 23 that protrudes from the bottom of the cover 18 toward the inlet 14 and surrounds the outside of the inlet 14 at a distance is such that the tip of the inlet 14 enters inside from the opening of the recess 23. Is set.

このように構成したため、所定量の試料液を注入口１４から注入してカバー１８を閉じた状態の分析用パネル３を分析用パネル保持部材１０１に装着してモータ１０２で回転駆動すると、保持チャンバー４にある試料液はこれまでの実施の形態と同様に、軸心１１から試薬チャンバー５の側に向かって矢印２５方向に移動する。一方、注入口１４の近傍に付着していた試料液滴１９は、遠心力によって矢印２６の方向に移動させられ、カバー１８の凹部２３に捕集される。つまり、注入口１４の近傍に付着した試料液滴１９は、カバー１８を閉めることで、カバー内で遮断し外部へ放出されるのを防止できる構造になっており、分析後もカバーを開放させることなく、汚染することなく、そのまま使い捨てが可能な使い捨ての分析用パネル向けに適するという効果がある。   With this configuration, when a predetermined amount of sample liquid is injected from the injection port 14 and the analysis panel 3 with the cover 18 closed is attached to the analysis panel holding member 101 and rotated by the motor 102, the holding chamber is obtained. The sample solution in 4 moves in the direction of the arrow 25 from the axis 11 toward the reagent chamber 5 as in the previous embodiments. On the other hand, the sample droplet 19 adhering to the vicinity of the inlet 14 is moved in the direction of the arrow 26 by the centrifugal force and collected in the concave portion 23 of the cover 18. That is, the sample droplet 19 adhering to the vicinity of the inlet 14 has a structure in which the cover 18 can be closed and prevented from being released to the outside by closing the cover 18, and the cover is opened even after analysis. Without being contaminated, there is an effect that it is suitable for a disposable analytical panel that can be disposable as it is.

なお、分析用パネル３に所定量の試料液を注入後、分析用パネル保持部材１０１に取り付け、試料液滴を移送するのに必要な回転数は、一般的には、１０００ｒｐｍ以上が必要であるが、凹部２３の内周全面，試料液滴１９の付着が予想される注入口１４の近傍に界面活性剤等で親水性処理を行った場合は、数百ｒｐｍの回転による遠心力を作用させるだけで、試料液滴を凹部２３の底部に移送して収集することも可能である。   In addition, after injecting a predetermined amount of the sample liquid into the analysis panel 3, it is attached to the analysis panel holding member 101, and the number of rotations necessary for transferring the sample droplet is generally 1000 rpm or more. However, when hydrophilic treatment is performed with a surfactant or the like on the entire inner peripheral surface of the recess 23 and in the vicinity of the injection port 14 where the sample droplet 19 is expected to adhere, a centrifugal force due to rotation of several hundred rpm is applied. It is also possible to transfer the sample droplet to the bottom of the recess 23 and collect it.

また、図１８に仮想線で示すように吸収部材２２を凹部２３に必要に応じて設けた場合には、注入口１４の近傍に付着した試料液滴１９が最終的には吸収部材２２に吸引されるので、凹部２３の開口を重力が作用する下側に傾けても、試料液が吸収部材２２の外へ漏れ出したり、注入口１４に移送され再度付着するのを防止できる効果がある。   In addition, when the absorbing member 22 is provided in the concave portion 23 as required, as indicated by the phantom line in FIG. 18, the sample droplet 19 adhering to the vicinity of the inlet 14 is finally sucked into the absorbing member 22. Therefore, even if the opening of the concave portion 23 is tilted to the lower side where the gravity acts, there is an effect that the sample liquid can be prevented from leaking out of the absorbing member 22 or being transferred to the inlet 14 and attached again.

また、実施の形態１と同様な凹部１２の構造をカバー１８内に設けてもよい。
また、前記凹部２３に連続してカバー１８内に毛細管力により試料液を保持する溝を形成してもよい。具体的には、図１９（ａ）（ｂ）（ｃ）に示すように構成する。図１９（ａ）は同実施の形態の分析用パネル３を分析装置の分析用パネル保持部材１０１に装着した状態における注入口の周辺の断面図を示す。図１９（ｂ）は注入口１４の方向からカバー１８の内側を見た正面図を示す。図１９（ｃ）は図１９（ｂ）におけるＢ−ＢＢ断面図で、図１９（ａ）の状態の水平断面図を示す。この図１９に示すように、凹部２３の底部に多数の隔壁２９が設けられている。隣接する隔壁２９との相互の間隔は、飛来した試料液滴１９を毛細管力で吸い取って保持する間隔に設定されており、分析用パネル保持部材１０１の回転によって注入口１４の周辺に付着していた試料液滴１９は、隔壁２９に飛来して隔壁２９の相互間に保持される。 The structure of the recess 12 similar to that of the first embodiment may be provided in the cover 18.
In addition, a groove for holding the sample solution by capillary force may be formed in the cover 18 continuously to the recess 23. Specifically, it is configured as shown in FIGS. 19 (a), 19 (b) and 19 (c). FIG. 19A shows a cross-sectional view of the periphery of the injection port in a state where the analysis panel 3 of the same embodiment is mounted on the analysis panel holding member 101 of the analyzer. FIG. 19B shows a front view of the inside of the cover 18 from the direction of the inlet 14. FIG. 19C is a B-BB cross-sectional view in FIG. 19B, and shows a horizontal cross-sectional view in the state of FIG. As shown in FIG. 19, a large number of partition walls 29 are provided at the bottom of the recess 23. The interval between the adjacent partition walls 29 is set to an interval for sucking and holding the flying sample droplet 19 by capillary force, and is attached to the periphery of the inlet 14 by the rotation of the analysis panel holding member 101. The sample droplet 19 comes to the partition wall 29 and is held between the partition walls 29.

本発明によれば、試料液と分析試薬の反応後の測定までを分析用パネル上で迅速に行え、特に試料液の注入に関して、操作性が非常に容易で汚染防止の面でも安全性が非常に高いので、血液などの分析装置として有用である。   According to the present invention, the measurement after the reaction between the sample solution and the analysis reagent can be performed quickly on the analysis panel. Particularly, in terms of the injection of the sample solution, the operability is very easy and the safety in terms of preventing contamination is very high. Therefore, it is useful as an analyzer for blood and the like.

本発明の実施の形態１における分析用パネルの外観斜視図1 is an external perspective view of an analysis panel according to Embodiment 1 of the present invention. 同実施の形態の分析用パネルの分解斜視図The exploded perspective view of the analysis panel of the embodiment 同分析用パネルを分析装置の分析用パネル保持部材へ装着した状態の斜視図A perspective view of the analysis panel mounted on the analysis panel holding member of the analyzer 同実施の形態の分析用パネルの注入口の周辺の拡大斜視図Enlarged perspective view around the inlet of the analysis panel of the same embodiment 同実施の形態の分析装置の構成図Configuration diagram of the analyzer of the same embodiment 同分析用パネルに開閉可能なカバーを取り付けた例を示す外観斜視図External perspective view showing an example in which an openable / closable cover is attached to the analysis panel 本発明の実施の形態２における分析用パネルの注入口の周辺の拡大断面図The expanded sectional view of the periphery of the inlet of the analysis panel in Embodiment 2 of this invention 同実施の形態の試料液滴の移送プロセスの説明図Explanatory drawing of the sample droplet transfer process of the embodiment 本発明の実施の形態３における分析用パネルの注入口の周辺の拡大断面図Enlarged sectional view around the inlet of the analysis panel according to the third embodiment of the present invention 同実施の形態の試料液滴の移送プロセスの説明図Explanatory drawing of the sample droplet transfer process of the embodiment 本発明の実施の形態４における分析用パネルの注入口の周辺の拡大断面図Enlarged sectional view around the inlet of the analysis panel according to Embodiment 4 of the present invention 同実施の形態の試料液滴の移送プロセスの説明図Explanatory drawing of the sample droplet transfer process of the embodiment 本発明の実施の形態５における分析用パネルの外観斜視図External perspective view of analysis panel according to Embodiment 5 of the present invention 同実施の形態の分析用パネルの分析装置への装着位置を示す斜視図The perspective view which shows the mounting position to the analyzer of the analysis panel of the embodiment 同分析用パネルを分析装置に装着した状態の注入口の周辺の断面図Sectional view around the inlet with the analysis panel installed in the analyzer 本発明の実施の形態６における分析用パネルのカバーを開いた外観斜視図External perspective view with cover of analysis panel open in Embodiment 6 of the present invention 同実施の形態のカバーを閉じた状態においてカバーを透視した斜視図The perspective view which saw through the cover in the state which closed the cover of the embodiment 同分析用パネルを分析装置に装着した状態の注入口の周辺の断面図Sectional view around the inlet with the analysis panel installed in the analyzer 別の実施例の（ａ）注入口の周辺の断面図と（ｂ）注入口からカバーを見た正面図と（ｃ）カバーの水平断面図(A) Cross-sectional view around the injection port, (b) Front view of the cover viewed from the injection port, and (c) Horizontal cross-sectional view of the cover in another embodiment 従来の分析用パネルを分析用パネル保持部に装着した様子を示す斜視図The perspective view which shows a mode that the conventional analysis panel was mounted | worn with the analysis panel holding | maintenance part.

符号の説明Explanation of symbols

１ 上部基板
２ 下部基板
３ 分析用パネル
４ 保持チャンバー
５ 試薬チャンバー
６ 流路
７ 測定チャンバー領域
８ 流路
９ 大気開放孔
１０ 分析装置
１１ 分析用パネル保持部材１０１の回転軸心
１２，２３ 凹部
１４ 注入口
１５，１６ 片面
１７ 溝部
１８ カバー
１９ 試料液滴
２０ 試料液の移送方向
２１ 溝部の開口部
２２ 吸収部材 DESCRIPTION OF SYMBOLS 1 Upper board | substrate 2 Lower board | substrate 3 Analysis panel 4 Holding chamber 5 Reagent chamber 6 Flow path 7 Measurement chamber area | region 8 Flow path 9 Atmospheric open hole 10 Analyzer 11 Rotation center of analysis panel holding member 101 12, 23 Recessed part 14 Note Inlet 15, 16 Single-sided 17 Groove 18 Cover 19 Sample droplet 20 Sample liquid transfer direction 21 Groove opening 22 Absorbing member

Claims (25)

パネル本体の一側面に試料液の注入口が設けられ、前記パネル本体の内部に前記注入口に連通して前記注入口に点着された試料液が移送されるチャンバーが設けられ、前記注入口を回転軸心側に配置した状態で前記パネル本体を回転させて、前記チャンバーで前記試料液中の成分の分析を行う分析用パネルであって、
前記注入口は、パネル本体の前記一側面よりチャンバーから離れる方向に突出した形状であるとともに、パネル本体の前記一側面前で前記注入口の周囲には凹部を形成した
分析用パネル。 A sample liquid injection port is provided on one side of the panel body, and a chamber is provided in the panel main body, the chamber being connected to the injection port and transferring the sample liquid spotted on the injection port. Is an analysis panel that analyzes the components in the sample solution in the chamber by rotating the panel body in a state of being arranged on the rotation axis side,
The analysis inlet panel has a shape protruding in a direction away from the chamber from the one side surface of the panel body, and a recess is formed around the injection port in front of the one side surface of the panel body. 前記注入口の突出量を、パネル本体の一側面とほぼ同等としたことを特徴とする
請求項１記載の分析用パネル。 The analysis panel according to claim 1, wherein a protruding amount of the inlet is substantially equal to one side surface of the panel main body. 前記凹部の開口部の断面積は、凹部の奥端における断面積よりも同等以上の大きさであることを特徴とする
請求項１記載の分析用パネル。 The analysis panel according to claim 1, wherein a cross-sectional area of the opening of the recess is equal to or greater than a cross-sectional area at the back end of the recess. 前記注入口は、前記凹部の底面を基端として突出していることを特徴とする
請求項１記載の分析用パネル。 The analysis panel according to claim 1, wherein the injection port protrudes with a bottom surface of the recess as a base end. 前記凹部の容積は、前記注入口への試料液の点着時に、前記注入口近傍に付着した試料液を受容できる大きさであることを特徴とする
請求項１記載の分析用パネル。 2. The analytical panel according to claim 1, wherein the volume of the recess is large enough to receive the sample liquid adhering to the vicinity of the inlet when the sample liquid is spotted on the inlet. 前記凹部に、前記試料液を吸収する吸収部材を配置したことを特徴とする
請求項１記載の分析用パネル。 The analysis panel according to claim 1, wherein an absorption member that absorbs the sample solution is disposed in the recess. 前記吸収部材を、前記軸心回りの回転により発生する遠心力によって凹部に移送された試料液に接触する位置に配置したことを特徴とする
請求項６記載の分析用パネル。 The analysis panel according to claim 6, wherein the absorbing member is disposed at a position in contact with the sample liquid transferred to the concave portion by a centrifugal force generated by rotation around the axis. 前記凹部に連通して、毛細管力により試料液を保持する溝部を形成したことを特徴とする
請求項１記載の分析用パネル。 The analysis panel according to claim 1, wherein a groove portion that communicates with the concave portion and holds the sample liquid by capillary force is formed. 前記溝部は、前記凹部の底部に連通していることを特徴とする
請求項８記載の分析用パネル。 The analysis panel according to claim 8, wherein the groove portion communicates with a bottom portion of the concave portion. 前記溝部は、前記軸心回りの回転により発生する遠心力によって、凹部に移送された試料液が、さらに前記遠心力によって内部に移送される形状であることを特徴とする請求項８記載の分析用パネル。   9. The analysis according to claim 8, wherein the groove has a shape in which the sample liquid transferred to the concave portion is further transferred to the inside by the centrifugal force due to the centrifugal force generated by the rotation around the axis. Panel. 前記凹部は、前記チャンバーと連通していることを特徴とする
請求項１記載の分析用パネル。 The analysis panel according to claim 1, wherein the recess communicates with the chamber. 前記凹部と前記チャンバーとを連通する通路を、注入口の近傍に付着した試料液が、前記軸心回りの回転により発生する遠心力によって前記チャンバー内に移送されるよう構成したことを特徴とする
請求項１１記載の分析用パネル。 The passage communicating the recess and the chamber is configured such that the sample liquid adhering to the vicinity of the injection port is transferred into the chamber by a centrifugal force generated by rotation around the axis. The analysis panel according to claim 11. 前記注入口に連通した前記チャンバーに、試料液としての血液の分析に使用する分析試薬を有することを特徴とする
請求項１記載の分析用パネル。 2. The analysis panel according to claim 1, wherein the chamber communicated with the inlet has an analysis reagent used for analyzing blood as a sample solution. 前記注入口と前記凹部を覆う開閉可能なカバーを備えたことを特徴とする
請求項１記載の分析用パネル。 The analysis panel according to claim 1, further comprising an openable / closable cover that covers the inlet and the recess. 前記注入口と前記凹部を覆う開閉可能なカバーを備え、
前記カバーの内側に試料液を吸収する吸収部材を設けたことを特徴とする
請求項１記載の分析用パネル。 An openable / closable cover covering the inlet and the recess;
The analysis panel according to claim 1, wherein an absorption member that absorbs the sample liquid is provided inside the cover. 前記注入口と前記凹部を覆う開閉可能なカバーを備え、
前記カバーの内側に試料液を吸収する吸収部材を設け、
前記注入口と前記吸収部材との間に空隙を形成したことを特徴とする
請求項１記載の分析用パネル。 An openable / closable cover covering the inlet and the recess;
An absorbing member that absorbs the sample liquid is provided inside the cover,
The analysis panel according to claim 1, wherein a gap is formed between the inlet and the absorbing member. 前記チャンバーは、
前記注入口に点着された試料液を一時的に保持する保持チャンバーと、
分析に必要な分析試薬を保持する試薬チャンバーと、
前記保持チャンバーに保持された試料液と前記分析試薬とが移送され、両者を混合させるとともに分析試薬と混合された試料液の測定が行われる測定チャンバー領域と
を備えることを特徴とする
請求項１記載の分析用パネル。 The chamber is
A holding chamber for temporarily holding the sample liquid spotted on the inlet;
A reagent chamber for holding analysis reagents necessary for analysis;
2. A measurement chamber region in which the sample liquid held in the holding chamber and the analysis reagent are transferred, mixed with each other, and measurement of the sample liquid mixed with the analysis reagent is performed. The analytical panel described. 前記注入口の周縁部の表面、前記凹部、前記凹部と前記チャンバーとを連通する通路、前記カバー部材の内面うちの少なくとも何れかに界面活性剤が塗布されていることを特徴とする
請求項１，請求項１２，請求項１４のいずれかに記載の分析用パネル。 2. The surfactant is applied to at least one of a peripheral surface of the injection port, the recess, a passage communicating the recess and the chamber, and an inner surface of the cover member. The analysis panel according to claim 12, or claim 14. パネル本体の一側面に設けられた試料液の注入口に連通して前記注入口に点着された試料液が移送されるチャンバーが内部に設けられた分析用パネルと、
前記分析用パネルが装着される分析用パネル保持部材と、
前記分析用パネル保持部材を回転させて発生した遠心力によって前記注入口に点着された試料液をチャンバーに移送し、前記チャンバーの試料液に対して光学的にアクセスして信号を検出して分析処理する分析装置であって、
前記分析用パネルに前記注入口を覆う開閉可能なカバーを設け、
前記カバーが閉じられた状態の前記分析用パネルを、前記注入口が前記分析用パネル保持部材の回転軸心を横切るよう前記分析用パネル保持部材に装着して分析動作するよう構成した
分析装置。 A panel for analysis in which a chamber in which a sample liquid spotted on the inlet is transferred in communication with an inlet of a sample liquid provided on one side surface of the panel body is provided;
An analysis panel holding member to which the analysis panel is mounted;
The sample liquid spotted on the inlet is transferred to the chamber by the centrifugal force generated by rotating the analysis panel holding member, and the signal is detected by optically accessing the sample liquid in the chamber. An analysis device for performing analysis processing,
An openable / closable cover for covering the inlet is provided on the analysis panel,
An analysis apparatus configured to perform an analysis operation by mounting the analysis panel in a state in which the cover is closed to the analysis panel holding member so that the inlet crosses the rotational axis of the analysis panel holding member. 前記カバーの内側に試料液を吸収する吸収部材を設けたことを特徴とする
請求項１９記載の分析装置。 The analyzer according to claim 19, wherein an absorption member that absorbs the sample liquid is provided inside the cover. 前記カバーの内側に、分析用パネルの前記注入口の近傍に付着していた試料液滴を捕集する凹部を設けたことを特徴とする
請求項１９記載の分析装置。 The analyzer according to claim 19, wherein a concave portion for collecting a sample droplet adhering to the vicinity of the inlet of the analysis panel is provided inside the cover. 前記凹部に毛細管力により試料液を保持する溝を形成したことを特徴とする
請求項２１記載の分析装置。 The analyzer according to claim 21, wherein a groove for holding the sample liquid is formed in the recess by capillary force. 分析用パネルの前記注入口の周縁部の表面、前記カバー部材の内面のうちの少なくとも何れかに界面活性剤が塗布されていることを特徴とする
請求項１９記載の分析装置。 The analyzer according to claim 19, wherein a surfactant is applied to at least one of the surface of the peripheral edge of the inlet of the analysis panel and the inner surface of the cover member. 請求項１〜請求項８のいずれかに記載の分析用パネルと、
前記分析用パネルが装着される分析用パネル保持部材と、
前記分析用パネル保持部材を回転させて発生した遠心力によって前記注入口に点着された試料液をチャンバーに移送し、前記チャンバーの試料液に対して光学的にアクセスして信号を検出して分析処理する分析装置であって、
前記分析用パネルを、前記注入口が前記分析用パネル保持部材の回転軸心寄りも外周側、または前記注入口が前記分析用パネル保持部材の回転軸心を横切るように、前記分析用パネル保持部材に装着して分析動作するよう構成した
分析装置。 The analysis panel according to any one of claims 1 to 8,
An analysis panel holding member to which the analysis panel is mounted;
The sample liquid spotted on the inlet is transferred to the chamber by the centrifugal force generated by rotating the analysis panel holding member, and the signal is detected by optically accessing the sample liquid in the chamber. An analysis device for performing analysis processing,
The analysis panel is held by the analysis panel so that the inlet closes to the outer peripheral side of the analysis panel holding member and the injection port crosses the rotation axis of the analysis panel holding member. An analyzer configured to be mounted on a member and perform an analysis operation. パネル本体の一側面に試料液の注入口が設けられ、前記パネル本体の内部に前記注入口に連通して前記注入口に点着された試料液が移送されるチャンバーが設けられ、前記パネル本体を軸心周りに回転させて、前記チャンバーで前記試料液中の成分の分析を行う分析用パネルであって、
前記注入口は、パネル本体の前記一側面よりチャンバーから離れる方向に突出した形状であるとともに、
前記注入口を覆う開閉可能なカバーを前記パネル本体に設け、
前記カバーの内側に、前記注入口の近傍に付着していた試料液滴を捕集する凹部または前記試料液滴を吸収する吸収部材を設け、
前記カバーが閉じられた状態では、前記注入口と前記凹部との間、または、前記注入口と前記吸収部材との間には空隙を形成した
分析用パネル。 A sample liquid inlet is provided on one side of the panel body, and a chamber is provided in the panel body, the chamber being connected to the inlet and transferring the sample liquid spotted on the inlet. An analysis panel for analyzing the components in the sample liquid in the chamber by rotating around the axis
The injection port has a shape protruding in a direction away from the chamber from the one side surface of the panel body,
A cover that can be opened and closed covering the inlet is provided on the panel body,
Provided inside the cover is a recess for collecting the sample droplets adhering to the vicinity of the inlet or an absorbing member for absorbing the sample droplets,
In the state in which the cover is closed, an analysis panel in which a gap is formed between the inlet and the recess, or between the inlet and the absorbing member.
JP2007168311A 2006-06-30 2007-06-27 Analysis panel and analyzer using the same Active JP4859769B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2007168311A JP4859769B2 (en) 2006-06-30 2007-06-27 Analysis panel and analyzer using the same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006180669 2006-06-30
JP2006180669 2006-06-30
JP2007168311A JP4859769B2 (en) 2006-06-30 2007-06-27 Analysis panel and analyzer using the same

Publications (2)

Publication Number Publication Date
JP2008032695A true JP2008032695A (en) 2008-02-14
JP4859769B2 JP4859769B2 (en) 2012-01-25

Family

ID=39122254

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007168311A Active JP4859769B2 (en) 2006-06-30 2007-06-27 Analysis panel and analyzer using the same

Country Status (1)

Country Link
JP (1) JP4859769B2 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009133831A (en) * 2007-10-30 2009-06-18 Panasonic Corp Analyzing device, and analyzing apparatus and method using the same
JP2009250906A (en) * 2008-04-10 2009-10-29 Panasonic Corp Analyzing device and sample liquid analyzing method using it
JP2010071644A (en) * 2008-09-16 2010-04-02 Panasonic Corp Analyzing device
CN102707044A (en) * 2012-05-31 2012-10-03 李云峰 Vertical western blot antibody incubation box
US9134286B2 (en) 2007-10-30 2015-09-15 Panasonic Healthcare Co., Ltd. Analyzing device, analyzing apparatus using the device, and analyzing method
EP2942104A1 (en) * 2014-05-08 2015-11-11 Radisens Diagnostics Ltd. Sample applicator for point of care device
WO2016153234A1 (en) * 2015-03-24 2016-09-29 삼성전자 주식회사 Microfluidic device and sample analysis device comprising same
CN107427834A (en) * 2015-03-24 2017-12-01 三星电子株式会社 Microfluidic device and the analyzing device including the microfluidic device
JPWO2020100987A1 (en) * 2018-11-16 2021-10-21 Ｐｈｃホールディングス株式会社 Substrate for sample analysis

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7271854B2 (en) 2019-02-26 2023-05-12 旭ファイバーグラス株式会社 Concrete curing structure and concrete curing method

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60154160A (en) * 1984-01-23 1985-08-13 Hitachi Koki Co Ltd Dispensing and measuring mechanism of centrifuged sample
JPH04504758A (en) * 1989-04-26 1992-08-20 マイグラータ　ユーケイ　リミテッド cuvette
JP2002243748A (en) * 2000-10-25 2002-08-28 Microparts G Fuer Mikrostrukturtechnik Mbh Device for analysis of fluid and controlled conveyance of fluid
JP2003185671A (en) * 2001-12-13 2003-07-03 Matsushita Electric Ind Co Ltd Disk for analysis
WO2003059484A1 (en) * 2001-12-28 2003-07-24 Hitachi, Ltd. Extractor, chemical analyzer, and chemical analyzing method
JP2004132962A (en) * 2002-08-12 2004-04-30 Bayer Healthcare Llc Fluid collecting and monitoring apparatus
JP2004239743A (en) * 2003-02-06 2004-08-26 Matsushita Electric Ind Co Ltd Disk for liquid sample analysis
JP2005249796A (en) * 2004-03-05 2005-09-15 Matthias Stiene Specimen inspection element and usage thereof
JP2006052949A (en) * 2004-08-09 2006-02-23 National Institute For Materials Science Blood analyzer and blood analyzing method
JP2006158335A (en) * 2004-12-09 2006-06-22 Olympus Corp Dividedly injecting device and culture treatment apparatus

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60154160A (en) * 1984-01-23 1985-08-13 Hitachi Koki Co Ltd Dispensing and measuring mechanism of centrifuged sample
JPH04504758A (en) * 1989-04-26 1992-08-20 マイグラータ　ユーケイ　リミテッド cuvette
JP2002243748A (en) * 2000-10-25 2002-08-28 Microparts G Fuer Mikrostrukturtechnik Mbh Device for analysis of fluid and controlled conveyance of fluid
JP2003185671A (en) * 2001-12-13 2003-07-03 Matsushita Electric Ind Co Ltd Disk for analysis
WO2003059484A1 (en) * 2001-12-28 2003-07-24 Hitachi, Ltd. Extractor, chemical analyzer, and chemical analyzing method
JP2004132962A (en) * 2002-08-12 2004-04-30 Bayer Healthcare Llc Fluid collecting and monitoring apparatus
JP2004239743A (en) * 2003-02-06 2004-08-26 Matsushita Electric Ind Co Ltd Disk for liquid sample analysis
JP2005249796A (en) * 2004-03-05 2005-09-15 Matthias Stiene Specimen inspection element and usage thereof
JP2006052949A (en) * 2004-08-09 2006-02-23 National Institute For Materials Science Blood analyzer and blood analyzing method
JP2006158335A (en) * 2004-12-09 2006-06-22 Olympus Corp Dividedly injecting device and culture treatment apparatus

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9757722B2 (en) 2007-10-30 2017-09-12 Panasonic Healthcare Holdings Co., Ltd. Microchannel analyzing device having a filling confirmation region
JP2009133831A (en) * 2007-10-30 2009-06-18 Panasonic Corp Analyzing device, and analyzing apparatus and method using the same
US10933413B2 (en) 2007-10-30 2021-03-02 Phc Holdings Corporation Analyzing device having spot application section with inclined face
US9134286B2 (en) 2007-10-30 2015-09-15 Panasonic Healthcare Co., Ltd. Analyzing device, analyzing apparatus using the device, and analyzing method
US10543484B2 (en) 2007-10-30 2020-01-28 Phc Holdings Corporation Analyzing device having an inlet with a liquid reservoir
JP2009250906A (en) * 2008-04-10 2009-10-29 Panasonic Corp Analyzing device and sample liquid analyzing method using it
JP2010071644A (en) * 2008-09-16 2010-04-02 Panasonic Corp Analyzing device
CN102707044A (en) * 2012-05-31 2012-10-03 李云峰 Vertical western blot antibody incubation box
EP2942104A1 (en) * 2014-05-08 2015-11-11 Radisens Diagnostics Ltd. Sample applicator for point of care device
US10376882B2 (en) 2014-05-08 2019-08-13 Radisens Diagnostics Ltd. Sample applicator for point of care device
WO2015169956A1 (en) 2014-05-08 2015-11-12 Radisens Diagnostics Ltd. Sample applicator for point of care device
JP2020126062A (en) * 2014-05-08 2020-08-20 ラディセンス ダイアグノスティクス リミテッド Sample applicator for point-of-care device
JP2022044735A (en) * 2014-05-08 2022-03-17 ラディセンス ダイアグノスティクス リミテッド Sample applicator for point-of-care device
WO2016153234A1 (en) * 2015-03-24 2016-09-29 삼성전자 주식회사 Microfluidic device and sample analysis device comprising same
EP3275549A4 (en) * 2015-03-24 2018-02-21 Samsung Electronics Co., Ltd. Microfluidic device and sample analysis device comprising same
CN107427834A (en) * 2015-03-24 2017-12-01 三星电子株式会社 Microfluidic device and the analyzing device including the microfluidic device
JP7174772B2 (en) 2018-11-16 2022-11-17 Ｐｈｃホールディングス株式会社 Substrate for sample analysis
JPWO2020100987A1 (en) * 2018-11-16 2021-10-21 Ｐｈｃホールディングス株式会社 Substrate for sample analysis

Also Published As

Publication number Publication date
JP4859769B2 (en) 2012-01-25

Similar Documents

Publication Publication Date Title
JP4859769B2 (en) Analysis panel and analyzer using the same
US20180221880A1 (en) Analyzing apparatus
US10543484B2 (en) Analyzing device having an inlet with a liquid reservoir
US7897398B2 (en) Centrifugal analysis device with improved mixing and method using the device
WO2008001796A1 (en) Panel for analysis and analyzer using the same
US8596150B2 (en) Analytical device with mixing cavity
JP6723409B2 (en) Analysis chip and sample analyzer
JP5376429B2 (en) Analytical device, analytical apparatus and analytical method using the same
US20100323454A1 (en) Analyzing device, and analyzing apparatus and analyzing method using the analyzing device
JP5376430B2 (en) Analytical device and analytical method using this analytical device
JP6590795B2 (en) Sample analyzer
JP6590796B2 (en) Sample analyzer
JP5273990B2 (en) Analytical device, analytical apparatus and analytical method using the same
WO2021020547A1 (en) Reagent cartridge
JP5274086B2 (en) Analytical device and sample liquid analysis method using the same
JP5958331B2 (en) Inspection chip and inspection system
JP2010151556A (en) Analyzer
JP2009115670A (en) Analyzing device and analysis apparatus and method using the same
JP2009092390A (en) Analysis device, and analysis apparatus and analysis method using the same

Legal Events

Date Code Title Description
RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20080430

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100308

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20110527

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110830

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110912

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20111004

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20111101

R151 Written notification of patent or utility model registration

Ref document number: 4859769

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R151

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20141111

Year of fee payment: 3

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S533 Written request for registration of change of name

Free format text: JAPANESE INTERMEDIATE CODE: R313533

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250