JP2007064829A - Testing tool - Google Patents

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Publication number
JP2007064829A
JP2007064829A JP2005252137A JP2005252137A JP2007064829A JP 2007064829 A JP2007064829 A JP 2007064829A JP 2005252137 A JP2005252137 A JP 2005252137A JP 2005252137 A JP2005252137 A JP 2005252137A JP 2007064829 A JP2007064829 A JP 2007064829A
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Prior art keywords
pressing member
liquid container
lid
liquid
absorbent material
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JP2005252137A
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Japanese (ja)
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Koji Gotanda
光司 五反田
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Fujirebio Inc
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Fujirebio Inc
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Priority to JP2005252137A priority Critical patent/JP2007064829A/en
Priority to PCT/JP2006/317202 priority patent/WO2007026814A1/en
Publication of JP2007064829A publication Critical patent/JP2007064829A/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber

Abstract

<P>PROBLEM TO BE SOLVED: To prevent a liquid in a liquid container from being splashed when breaking a sealing member of the liquid container by pushing down a seal breaker, and to stably and uniformly permeate the liquid into the first absorption material, in a testing tool constituted to push-break the sealing member of the liquid container stored in a case main body by the seal breaker of a lid in order to develop thereby the liquid in the liquid container to a detecting part. <P>SOLUTION: The seal breaker 9 is provided with a breaking piece 22, and a pressing member 21 provided to cover the breaking piece 22, for the use in the present invention. The breaking piece 22 is pushed by the pressing member 21 to break directly the sealing member 3 of the liquid container 4, and the first absorption material 5 is immersed into the liquid container 4. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

この発明は、免疫測定などにおける検体中の測定対象物を検知するためのディスポーザブルタイプの試験用具に関する。   The present invention relates to a disposable type test tool for detecting a measurement object in a specimen in immunoassay or the like.

従来、この種の試験用具として、測定対象物を展開液により展開して検出部まで移送するタイプのものが知られており、小型で、高感度で、簡単かつ迅速に検知ができるとされている。
このような試験用具の一例として、特許第３２３７５４０号公報に開示のものがある。 Conventionally, as this type of test tool, a type in which a measurement object is developed with a developing solution and transferred to a detection unit is known, and is said to be small, highly sensitive, and easily and quickly detected. Yes.
An example of such a test tool is disclosed in Japanese Patent No. 3327540.

この試験用具は、例えば酵素免疫検定法（ＥＩＡ）に用いられる場合、図５および図６に示すように、全体の形状が細長い箱状となっており、ケース本体１とこのケース本体１を覆う蓋部２とから概略構成されている。
ケース本体１には、図６に示すように、その長手方向の一端部側に、アルミニウム箔などのシール部材３で密閉され、内部に展開液が満たされた液体容器４が収容されている。この液体容器４のシール部材３上には、テープ状の第１の吸収材５が載置されている。 When this test tool is used, for example, in an enzyme immunoassay (EIA), as shown in FIGS. 5 and 6, the overall shape is an elongated box shape, and covers the case body 1 and the case body 1. The lid 2 is schematically configured.
As shown in FIG. 6, the case body 1 accommodates a liquid container 4 that is sealed with a sealing member 3 such as an aluminum foil and filled with a developing solution at one end in the longitudinal direction. On the seal member 3 of the liquid container 4, a tape-shaped first absorbent material 5 is placed.

この第１の吸収材５の一方の端部側には、テープ状の第２の吸収材６の一端部が、第１の吸収材５の下側であってシール部材３の上側に、第１の吸収材５と重なり合うように置かれている。また、第２の吸収材６の長手方向のほぼ中間位置には、第３の吸収材７がこの上に置かれている。さらに、第２の吸収材６の他端部側には、第４の吸収材８がこの上に載置されている。   One end of the first absorbent 5 has one end of a tape-like second absorbent 6 below the first absorbent 5 and above the seal member 3. It is placed so as to overlap one absorbent material 5. A third absorbent material 7 is placed on the second absorbent material 6 at a substantially intermediate position in the longitudinal direction. Furthermore, on the other end side of the second absorbent material 6, a fourth absorbent material 8 is placed thereon.

上記第１の吸収材５には、特定の酵素、例えばアルカリホスタファーゼの場合には、この酵素で分解し発色する基質、例えば５−ブロモ−４−クロロ−３−インドリルリン酸ナトリウム（ＢＣＩＰ）やｐ−ニトロフェニルホスフェートなどを含有した吸水性の不織布、濾紙などが用いられる。
また、第２の吸収材６には、測定対象物と特異的に結合する第１の物質（例えば、抗原、抗体など）が固定されている検出部を有するニトロセルロースのメンブランなどが用いられる。 In the case of the first absorbent 5, in the case of a specific enzyme such as alkaline hostase, a substrate that decomposes and develops color with this enzyme, such as sodium 5-bromo-4-chloro-3-indolylphosphate ( BCIP), water-absorbing nonwoven fabric containing p-nitrophenyl phosphate, filter paper, and the like are used.
As the second absorbent material 6, a nitrocellulose membrane having a detection unit on which a first substance (for example, an antigen, an antibody, etc.) that specifically binds to the measurement object is fixed is used.

第３の吸収材７には、上記特定の酵素、例えばアルカリホスタファーゼで標識された測定対象物と特異的に結合する第２の物質（例えば、酵素標識抗原、酵素標識抗体など）を含有する吸水性の不織布、濾紙などが用いられる。
第４の吸収材８には、試薬を含まない吸水性の不織布、濾紙などが用いられる。 The third absorbent material 7 contains a second substance (for example, enzyme-labeled antigen, enzyme-labeled antibody, etc.) that specifically binds to the measurement target labeled with the specific enzyme, for example, alkaline hostase. Water-absorbing nonwoven fabric, filter paper, etc. are used.
For the fourth absorbent 8, a water-absorbing non-woven fabric or a filter paper that does not contain a reagent is used.

一方、このケース本体１を覆う蓋部２には、図５に示すように、その長手方向の一端側から、シールブレイカー９、検体滴下窓１０、判定窓１１および蒸散窓１２がこの順序で他端側に向けて所定の間隔を介して設けられている。
そして、この蓋部２は、そのシールブレイカー９がケース本体１の液体容器４上に、検体滴下窓１０が第３の吸収材７上に、判定窓１１が第２の吸収材６の検出部上に、蒸散窓１２が第４の吸収材８上にそれぞれ位置するようケース本体１に重ね合わせられている。 On the other hand, as shown in FIG. 5, a seal breaker 9, a specimen dropping window 10, a determination window 11, and a transpiration window 12 are arranged in this order on the lid portion 2 covering the case body 1 from one end side in the longitudinal direction. It is provided at a predetermined interval toward the end side.
The lid 2 has a seal breaker 9 on the liquid container 4 of the case body 1, a specimen dropping window 10 on the third absorbent 7, and a determination window 11 on the second absorbent 6 detection unit. Above, the transpiration window 12 is overlaid on the case body 1 so as to be positioned on the fourth absorbent material 8 respectively.

上記シールブレイカー９は、図７に示すように、大屋根部１３と、この大屋根部１３の反対側に延びる小屋根部１４と、大屋根部１３と小屋根部１４との側方に延びる２つの側屋根部１５、１５とからなる寄棟屋根状の部材である。
また、このシールブレイカー９のこれらの各屋根部１３、１４、１５のそれぞれの境界となる稜線部分は、弱化線部１６となっている。 As shown in FIG. 7, the seal breaker 9 includes a large roof portion 13, a small roof portion 14 extending on the opposite side of the large roof portion 13, and two sides extending laterally between the large roof portion 13 and the small roof portion 14. It is a dormitory roof-like member composed of side roof portions 15 and 15.
Moreover, the ridge line part used as the boundary of each of these roof parts 13,14,15 of this seal breaker 9 is the weakening line part 16. FIG.

この弱化線部１６は、シールブレイカー９をなす材料の厚さを薄くして形成した部分であり、この弱化線部１６が存在することで、シールブレイカー９を押し下げた際、シールブレイカー９が不可逆的に押し込められた状態になる。また、シールブレイカー９の大屋根部１３は、上記第２の吸収材６側に配設されている。   The weakened line portion 16 is a portion formed by reducing the thickness of the material forming the seal breaker 9, and the presence of the weakened line portion 16 makes the seal breaker 9 irreversible when the seal breaker 9 is pushed down. Will be pushed in. The large roof portion 13 of the seal breaker 9 is disposed on the second absorbent material 6 side.

さらに、シールブレイカー９の大屋根部１３の頂部の裏側から、破断突起１８が垂下して設けられている。この破断突起１８は、シールブレイカー９を押し下げた際に、第１の吸収材５の一部を下方に押しつけるとともに液体容器４のシール部材３を破断し、第１の吸収材５の一部を液体容器４内に満たされた展開液に浸すようにするものである。この破断突起１８は、板状のもので、その長手方向が蓋部２の長手方向に直交するように配置されている。   Further, a fracture protrusion 18 is provided to hang down from the back side of the top of the large roof portion 13 of the seal breaker 9. When the seal breaker 9 is pushed down, the fracture protrusion 18 presses a part of the first absorbent material 5 downward, breaks the seal member 3 of the liquid container 4, and removes a part of the first absorbent material 5. The liquid container 4 is immersed in a developing liquid. The fracture protrusions 18 are plate-shaped, and are arranged so that the longitudinal direction thereof is orthogonal to the longitudinal direction of the lid portion 2.

上記ケース本体１および蓋部２は、低密度ポリエチレン、ポリプロピレンなどの熱可塑性樹脂を精密射出成形して形成されたものであって、両者を機械的に嵌合する方法や熱溶着する方法などで組み立てられている。   The case body 1 and the lid portion 2 are formed by precision injection molding of a thermoplastic resin such as low density polyethylene or polypropylene. The case body 1 and the lid portion 2 may be mechanically fitted to each other or thermally welded. It is assembled.

このような試験用具にあっては、試料液を検体滴下窓１０に滴下し、第３の吸収材７に吸収させる。ついで、シールブレイカー９の大屋根部１３を指先等で押し下げる。これにより、上述のように、破断突起１８が押し下げられ、第１の吸収材５の一部が液体容器４の展開液に浸され、展開液が第１の吸収材５から第２の吸収材６に展開、移動し、さらに第４の吸収材８に向けて展開、移動する。
一定時間経過後、判定窓１１を介して第２の吸収材６の検出部を観察し、判定窓１１における発色を確認し、検体中の測定対象物について陽性または陰性の判定を行う。 In such a test tool, the sample solution is dropped on the specimen dropping window 10 and is absorbed by the third absorbent 7. Next, the large roof portion 13 of the seal breaker 9 is pushed down with a fingertip or the like. Thereby, as described above, the fracture protrusion 18 is pushed down, a part of the first absorbent 5 is immersed in the developing liquid in the liquid container 4, and the developing liquid is transferred from the first absorbent 5 to the second absorbent. 6 expands and moves, and further expands and moves toward the fourth absorbent 8.
After a lapse of a certain time, the detection part of the second absorbent material 6 is observed through the determination window 11, the coloration in the determination window 11 is confirmed, and the measurement object in the sample is determined to be positive or negative.

ところで、このような従来の試験用具の使用にあっては、図８（ａ）に示すように、シールブレイカー９の大屋根部１３を押し下げる操作を行う。この時、破断突起１８は、図８（ｂ）に示すように、まず第１の吸収材５を下方に押し下げ、ついでこの第１の吸収材５を介して液体容器４のシール部材３を押し下げ、突き破ることになる。   By the way, in using such a conventional test tool, an operation of pushing down the large roof portion 13 of the seal breaker 9 is performed as shown in FIG. At this time, as shown in FIG. 8B, the breaking protrusion 18 first pushes down the first absorbent material 5, and then pushes down the seal member 3 of the liquid container 4 via the first absorbent material 5. , Will break through.

このようなシール部材３の破断形態では、厚さの厚い第１の吸収材５がシール部材３を押し破って、液体中に押し込まれるため、液体容器４中の液体が飛び散り、所定量の液体を浸透させることができないことがあった。また、大屋根部１３の押圧方向によっては、シールブレイカー９が斜めに吸収材５を液体容器４中に押し込むため、第１の吸収材５への液体の浸透が不均一になることもあった。
特許第３２３７５４０号公報 In such a ruptured form of the seal member 3, since the thick first absorbent member 5 pushes through the seal member 3 and is pushed into the liquid, the liquid in the liquid container 4 is scattered, and a predetermined amount of liquid In some cases, it was not possible to penetrate. Further, depending on the pressing direction of the large roof portion 13, the seal breaker 9 pushes the absorbent material 5 into the liquid container 4 at an angle, so that the liquid permeation into the first absorbent material 5 may become non-uniform. .
Japanese Patent No. 3327540

よって、本発明における課題は、シールブレイカーを押し下げて、液体容器のシール部材を破断する際に、液体容器中の液体が飛散することを防止し、かつ第１の吸収材への液体の浸透が安定して均一に行われるようにすることにある。   Therefore, the problem in the present invention is that when the seal breaker is pushed down to break the seal member of the liquid container, the liquid in the liquid container is prevented from splashing and the penetration of the liquid into the first absorbent material is prevented. The goal is to be stable and uniform.

かかる課題を解決するため、
請求項１にかかる発明は、ケース本体と、このケース本体を覆う蓋部とからなり、
ケース本体には、シール部材で密閉された液体容器と、この液体容器のシール部材上に載置された第１の吸収材が設けられており、
蓋部には、シールブレイカーが形成されており、
上記蓋部は、そのシールブレイカーが第１の吸収材上に位置するようにしてケース本体に取り付けられ、
上記シールブレイカーは、破断片と、この破断片を覆うようにして設けられた押圧部材を備えており、
上記破断片は、押圧部材に押圧されて上記液体容器のシール部材を直接破るとともに上記第１の吸収材を液体容器中の液体に浸すものであることを特徴とする試験用具である。 To solve this problem,
The invention according to claim 1 includes a case main body and a lid portion covering the case main body.
The case body is provided with a liquid container sealed with a sealing member and a first absorbent material placed on the sealing member of the liquid container,
A seal breaker is formed on the lid,
The lid is attached to the case body so that the seal breaker is positioned on the first absorbent material,
The seal breaker includes a broken piece and a pressing member provided so as to cover the broken piece,
The broken piece is a test tool that is pressed by the pressing member to directly break the sealing member of the liquid container and immerses the first absorbent in the liquid in the liquid container.

請求項２にかかる発明は、上記押圧部材は、壁部とこの壁部に連設された片流れ状の屋根部を有し、屋根部の下部が上記蓋部に対して回動可能に取り付けられ、壁部の下部が蓋部に対して離脱可能に取り付けられ、
上記破断片は、板状であって、その長手方向の一端部のみが蓋部に対して対して回動可能に取り付けられ、その長手方向の他端部には破断突起が設けられ、この破断突起が上記第１の吸収材の外方に位置するように設けられていることを特徴とする請求項１記載の試験用具である。 According to a second aspect of the present invention, the pressing member has a wall portion and a single-flow roof portion provided continuously to the wall portion, and a lower portion of the roof portion is rotatably attached to the lid portion. The lower part of the wall part is detachably attached to the lid part,
The broken piece is plate-shaped, and only one end portion in the longitudinal direction thereof is rotatably attached to the lid portion, and a breaking protrusion is provided at the other end portion in the longitudinal direction. The test tool according to claim 1, wherein the protrusion is provided so as to be located outside the first absorbent material.

請求項３にかかる発明は、上記押圧部材の壁部には、係合凹部が形成され、上記蓋部には、この係合凹部に離脱可能に係止する係合凸部が設けられており、
押圧部材を押圧しない状態では、上記係合凸部と上記係合凹部が互いに係合して押圧部材が蓋部から上方に突出した状態になっており、
押圧部材を押圧したあとの状態では、上記壁部の上部が上記係合凸部に係止され、押圧前の元の位置に復帰できないようになっていることを特徴とする請求項２記載の試験用具である。 According to a third aspect of the present invention, an engagement recess is formed in the wall portion of the pressing member, and an engagement projection is provided on the lid so as to be releasably locked to the engagement recess. ,
In a state where the pressing member is not pressed, the engaging convex portion and the engaging concave portion are engaged with each other, and the pressing member protrudes upward from the lid portion,
The upper part of the said wall part is latched by the said engagement convex part in the state after pressing a press member, It cannot prevent returning to the original position before a press. It is a test tool.

本発明によれば、上記押圧部材を指等で押し下げることで、上記係合凸部と上記係合凹部との係合が解除され、押圧部材自体が回動して押し下げられる。この押圧部材の押し下げにより、破断片が回動して押し下げられ、まずその先端の破断突起が液体容器のシール部材を直接押し破る。すなわち、破断片の破断突起の位置が第１の吸収材の外方になるように定められているので、第１の吸収材を介してシール部材を押し破ることはない。   According to the present invention, by pressing down the pressing member with a finger or the like, the engagement between the engaging convex portion and the engaging concave portion is released, and the pressing member itself is rotated and pressed down. By pushing down the pressing member, the broken piece is rotated and pushed down. First, the breaking protrusion at the tip directly pushes the sealing member of the liquid container. That is, since the position of the breaking protrusion of the broken piece is determined to be outside the first absorbent material, the sealing member is not pushed through the first absorbent material.

続いて、押圧部材のさらなる押し下げにより破断片が第１の吸収材を押し下げ、既に破られたシール部材の空隙を押し拡げて第１の吸収材が液体容器中の液体に浸される。
このような動作を行うことで、第１の吸収材が液体容器中の液体に浸される際に急激に浸されることがなくなり、液体が飛散することがなくなる。また、第１の吸収材が板状の破断片に押されるため、第１の吸収材の端部が広い面積で液体中に没することになって、液体の浸透が安定して均一に行われる。 Subsequently, the broken piece pushes down the first absorbent material by further pushing down the pressing member, and the first absorbent material is immersed in the liquid in the liquid container by expanding the gap of the already broken seal member.
By performing such an operation, when the first absorbent material is immersed in the liquid in the liquid container, it is not suddenly immersed, and the liquid does not scatter. Further, since the first absorbent material is pushed by the plate-shaped fracture piece, the end of the first absorbent material is submerged in the liquid in a large area, so that the penetration of the liquid is performed stably and uniformly. Is called.

また、押圧部材の押し下げ操作が終了後、押圧部材の壁部の上部が上記係合凸部に係止し、押圧部材の上方への回動が阻止されて元の状態に復帰することがない。このため、試験用具が使用済みであるか、使用後であるかを容易に外観から簡単に視認できる。   In addition, after the pressing-down operation of the pressing member is completed, the upper portion of the wall portion of the pressing member is locked to the engaging convex portion, and the upward rotation of the pressing member is prevented and the original state is not restored. . For this reason, it can be easily visually recognized from the appearance whether the test tool has been used or after use.

さらに、押圧部材を押し下げない状態では、押圧部材の係止凹部に蓋部の係止凸部が嵌合した状態となっており、ある程度の力（１〜２ｋｇ）を加えて押し下げない限り、押圧部材が押し下げられることがない。このため、誤操作が防止できるとともに、外観から試験用具が未使用であることが確認できる。   Furthermore, in a state where the pressing member is not pushed down, the locking convex portion of the lid portion is fitted to the locking concave portion of the pressing member, and the pressing member is pressed unless pressed down by applying a certain amount of force (1-2 kg). The member is not pushed down. For this reason, it is possible to prevent erroneous operation and to confirm from the appearance that the test tool is unused.

以下、本発明を図面に基づいて詳しく説明する。
図１および図２は、本発明の試験用具の要部であるシールブレイカーとその周辺部の一例を示すもので、これ以外の部分は先に説明した従来のものと同一であるので、その説明を省略する。
図１は、試験用具をその長手方向に沿って切断した断面図であって、従来のものと同一構成要件には同一符号を付してある。また、図２は図１のＩＩ−ＩＩ線で断面視した断面図である。 Hereinafter, the present invention will be described in detail with reference to the drawings.
FIG. 1 and FIG. 2 show an example of a seal breaker which is a main part of the test tool of the present invention and its peripheral part, and the other parts are the same as the conventional ones described above, so that explanation Is omitted.
FIG. 1 is a cross-sectional view of a test tool cut along its longitudinal direction, and the same reference numerals are given to the same constituent elements as those in the prior art. 2 is a cross-sectional view taken along line II-II in FIG.

この例において、シールブレイカー９は、押圧部材２１と破断片２２とから概略構成されている。
押圧部材２１は、ほぼ鉛直方向に配置された平面形状が矩形の１枚の壁部２３Ａと、この壁部２３Ａの側方に延びる平面形状が三角形の２枚の側壁部（図示せず）と、壁部２３Ａと側壁部の上部に連接された片流れ状に傾斜し平面形状が矩形の屋根部２４とから構成されている。上記壁部２３Ａの下部の外表面には水平方向に延びる溝状の係合凹部２５が形成されている。 In this example, the seal breaker 9 is generally constituted by a pressing member 21 and a broken piece 22.
The pressing member 21 includes one wall portion 23A having a rectangular planar shape arranged in a substantially vertical direction, and two side wall portions (not shown) having a triangular planar shape extending to the side of the wall portion 23A. The roof portion 24 is composed of a wall portion 23A and a roof portion 24 which is connected to the upper portion of the side wall portion and is slanted in a single flow shape and has a rectangular planar shape. A groove-like engaging recess 25 extending in the horizontal direction is formed on the outer surface of the lower portion of the wall portion 23A.

上記屋根部２４の外表面には複数の小さな半球状の凹部２６、２６・・が形成され、滑り止めとして機能するようになっている。また、屋根部２４の下部は、蓋部２に対して回動可能に取り付けられている。すなわち、蓋部２のシールブレイカー９の周囲部分には、これを取り囲むようにして隆起した堤部２７が形成されており、この堤部２７の相対向する２箇所に軸支穴（図示せず）が形成され、この軸支穴に屋根部２４に下部から横方向に延びる軸棒（図示せず）が挿入されており、これにより蓋部２に対して押圧部材２１が回動可能に取り付けられている。
また、押圧部材２１の内部空間にはその長手方向に延びる２本の補強用リブ２１Ａ、２１Ａが互いに平行に間隔を配して設けられている。 A plurality of small hemispherical concave portions 26, 26,... Are formed on the outer surface of the roof portion 24 so as to function as slip stoppers. Moreover, the lower part of the roof part 24 is attached with respect to the cover part 2 so that rotation is possible. That is, a bank portion 27 is formed around the seal breaker 9 of the lid portion 2 so as to surround the seal breaker 9, and shaft support holes (not shown) are formed at two opposite locations of the bank portion 27. ) Is formed, and a shaft rod (not shown) extending in the lateral direction from the lower portion is inserted into the shaft support hole in the shaft support hole, whereby the pressing member 21 is rotatably attached to the lid portion 2. It has been.
Further, two reinforcing ribs 21 </ b> A and 21 </ b> A extending in the longitudinal direction are provided in the internal space of the pressing member 21 so as to be spaced apart from each other in parallel.

上記破断片２２は、押圧部材２１の下方に位置し、押圧部材２１に覆われるようにして設けられている。この破断片２２は、平面形状が矩形の板材からなるもので、その長手方向に沿って補強リブ２８が形成されている。また、破断片２２は、その長手方向の基端部のみでヒンジ部２７Ａを介して蓋部２の堤部２７に取り付けられ、これ以外の周辺部は堤部２７から離れており、これによって破断片２２は蓋部２に対して回動可能となっている。   The broken piece 22 is located below the pressing member 21 and is provided so as to be covered with the pressing member 21. The fracture piece 22 is made of a plate having a rectangular planar shape, and reinforcing ribs 28 are formed along the longitudinal direction thereof. In addition, the broken piece 22 is attached to the bank portion 27 of the lid portion 2 via the hinge portion 27A only at the base end portion in the longitudinal direction, and the other peripheral portion is separated from the bank portion 27, thereby breaking. The fragment 22 is rotatable with respect to the lid 2.

さらに、破断片２２の長手方向の先端部の下面側には、４個の小さな破断突起２９、２９・・が、その短手方向に一列に間隔を配して設けられている。   Further, on the lower surface side of the distal end portion in the longitudinal direction of the fracture piece 22, four small fracture projections 29, 29,...

また、上記堤部２７には、その押圧部材２１の壁部２３に形成された係合凹部２５に対応する位置に、水平方向に突出した土手状の係合凸部３０が設けられており、この係合凸部３０と係合凹部２５とが弾性変形して互いに係止もしくは離間できるようになっており、これにより押圧部材２１が蓋部２に対して離脱可能になっている。   Further, the bank portion 27 is provided with a bank-like engagement convex portion 30 protruding in the horizontal direction at a position corresponding to the engagement concave portion 25 formed in the wall portion 23 of the pressing member 21. The engaging convex portion 30 and the engaging concave portion 25 are elastically deformed so that they can be locked or separated from each other, whereby the pressing member 21 can be detached from the lid portion 2.

さらに、押圧部材２１の内側空間に設けられた２本の補強用リブ２１Ａ、２１Ａと側壁部との下端面は、破断片２２の上表面とほぼ接するように、押圧部材２１と破断片２２とが位置決めされている。   Further, the pressing member 21 and the broken piece 22 are arranged so that the lower end surfaces of the two reinforcing ribs 21A and 21A provided in the inner space of the pressing member 21 and the side wall portion are substantially in contact with the upper surface of the broken piece 22. Is positioned.

また、第１の吸収材５の先端部の位置が、破断片２２の先端部の破断突起２９、２９・・の位置よりも内方に下がっていて、破断突起２９、２９・・が下方に降りた際に、これが第１の吸収材５に当たらないようになっている。   Further, the position of the tip of the first absorbent member 5 is inwardly lower than the positions of the break protrusions 29, 29,... At the tip of the broken piece 22, and the break protrusions 29, 29,. When it gets off, it does not hit the first absorbent material 5.

図中符号４は、ケース本体１に設けられた液体容器を示し、符号３は、この液体容器４の開口部を封止するアルミニウム箔などからなるシール部材を示す。
この例の液体容器４では、その底部３１の形状が従来のものと若干異なっている。
この底部３１は、図示したように後方に傾斜した前部３２とほぼ水平な中間部３３と前方に傾斜した後部３４とからなっている。 In the figure, reference numeral 4 denotes a liquid container provided in the case body 1, and reference numeral 3 denotes a sealing member made of an aluminum foil or the like for sealing the opening of the liquid container 4.
In the liquid container 4 of this example, the shape of the bottom 31 is slightly different from the conventional one.
As shown in the figure, the bottom portion 31 includes a front portion 32 inclined rearward, a substantially horizontal intermediate portion 33, and a rear portion 34 inclined forward.

そして、後部３４の長さが液体容器２の長さのほぼ半分を占め、前部３２の長さがこれよりもかなり短くなっていて、前部３２と中間部３３との側に液体が多く溜まるようになっている。その結果、少量の液体でも液体容器２に液体が残ることがなく、確実に液体を浸透させることができる。
なお、図１および図２に示した状態は、試験用具の使用前の状態を描いたものである。 The length of the rear part 34 occupies almost half of the length of the liquid container 2, the length of the front part 32 is considerably shorter than this, and there is a lot of liquid on the side of the front part 32 and the intermediate part 33. It has come to accumulate. As a result, even with a small amount of liquid, the liquid does not remain in the liquid container 2, and the liquid can be surely permeated.
In addition, the state shown in FIG. 1 and FIG. 2 depicts the state before use of the test tool.

この例の試験用具を使用する場合には、シールブレイカー９の押圧部材２１を指先等で押し下げる。この時、押圧部材２１の係合凹部２５と堤部２７の係合凸部３０が係止状態となっているので、１〜２ｋｇ程度の力を加えたときに初めてかかる係合が解除されて、押圧部材２１がその軸棒を中心として回動して押し下げられる。   When the test tool of this example is used, the pressing member 21 of the seal breaker 9 is pushed down with a fingertip or the like. At this time, since the engaging concave portion 25 of the pressing member 21 and the engaging convex portion 30 of the bank portion 27 are in a locked state, the engagement is not released until a force of about 1 to 2 kg is applied. The pressing member 21 is rotated about the shaft rod and pushed down.

そして、押圧部材２１の補強用リブ２１Ａと側壁部との下端面が破断片２２の上表面とほぼ接しているので、押圧部材２１の押し下げと同時に破断片２２も下方に押し下げられる。この破断片２２の押し下げにより、その破断突起２９、２９・・が液体容器４のシール部材３に当たり、これを突き破る。   Since the lower end surfaces of the reinforcing rib 21A and the side wall portion of the pressing member 21 are substantially in contact with the upper surface of the broken piece 22, the broken piece 22 is pushed downward simultaneously with the pressing of the pressing member 21. When the broken piece 22 is pushed down, the broken projections 29, 29... Hit the seal member 3 of the liquid container 4 and break through it.

さらなる押圧部材２１および破断片２２の押し下げにより、第１の吸収材５がその先端側の部分からシール部材３の突き破られて生じた空隙を押し拡げつつ液体容器４内に押し込まれ、第１の吸収材５が液体中に浸される。
液体容器４の液体中に浸された第１の吸収材５は、図２に示すように、破断片２２全体で押し込まれた状態となっていて、液体容器４の底部３１の形状に沿った状態となっている。 When the pressing member 21 and the broken piece 22 are further pushed down, the first absorbent member 5 is pushed into the liquid container 4 while expanding the gap generated by the breakage of the seal member 3 from the tip side thereof, and the first absorbent member 5 is pushed. The absorbent material 5 is immersed in the liquid.
As shown in FIG. 2, the first absorbent material 5 immersed in the liquid of the liquid container 4 is in a state of being pushed in the whole broken piece 22, and conforms to the shape of the bottom 31 of the liquid container 4. It is in a state.

図３は、押圧部材２１を押し下げ切った状態を示すもので、この状態では押圧部材２１の壁部２３Ａの上部が堤部２７に設けられた係合凸部３０に当たって上方への移動が阻止され、押圧部材２１および破断片２２が元の使用前の状態に復帰することがない。   FIG. 3 shows a state in which the pressing member 21 is pushed down. In this state, the upper portion of the wall portion 23A of the pressing member 21 hits the engaging convex portion 30 provided on the bank portion 27 and is prevented from moving upward. The pressing member 21 and the broken piece 22 do not return to the original state before use.

このため、この例の試験用具にあっては、押圧部材２１の押し下げにより、破断片２２が回動して押し下げられ、まずその先端の破断突起２９・２９・・が液体容器４のシール部材３を直接押し破る。すなわち、第１の吸収材５を介してシール部材３を押し破ることはない。   For this reason, in the test tool of this example, when the pressing member 21 is pushed down, the broken piece 22 is rotated and pushed down. First, the breaking protrusions 29, 29,. Directly break through. That is, the sealing member 3 is not pushed through the first absorbent material 5.

このため、第１の吸収材５が液体容器４中の液体に浸される際に急激に浸されることがなくなり、液体が飛散することがなくなる。また、第１の吸収材５が板状の破断片２２に押されるため、第１の吸収材５が広い面積で液体中に没することになって、液体の浸透が安定して均一に行われる。   For this reason, when the 1st absorber 5 is immersed in the liquid in the liquid container 4, it will not be immersed suddenly and a liquid will not scatter. Further, since the first absorbent material 5 is pushed by the plate-shaped fracture piece 22, the first absorbent material 5 is submerged in the liquid over a wide area, so that the liquid permeation is stably and uniformly performed. Is called.

また、押圧部材２１の押し下げ操作が終了後、押圧部材２１の壁部２３Ａの上部が上記係合凸部３０に係止し、押圧部材２１の上方への回動が阻止されて元の状態に復帰することがない。このため、試験用具が使用済みであることが外観から簡単に視認できる。   In addition, after the pressing operation of the pressing member 21 is finished, the upper portion of the wall portion 23A of the pressing member 21 is locked to the engaging convex portion 30, and the upward rotation of the pressing member 21 is prevented to return to the original state. There is no return. For this reason, it can be easily visually recognized from the appearance that the test tool has been used.

さらに、押圧部材２１を押し下げない状態では、押圧部材２１の係止凹部２５に蓋部２の係止凸部３０が嵌合した状態となっており、ある程度の力（１〜２ｋｇ）を加えて押し下げない限り、押圧部材２１が押し下げられることがない。このため、誤操作が防止できるとともに、外観から試験用具が未使用であることが確認できる。   Further, in a state where the pressing member 21 is not pushed down, the locking convex portion 30 of the lid portion 2 is fitted to the locking concave portion 25 of the pressing member 21, and a certain amount of force (1-2 kg) is applied. Unless pressed down, the pressing member 21 is not pressed down. For this reason, it is possible to prevent erroneous operation and to confirm from the appearance that the test tool is unused.

また、液体容器４の底部３１の形状を図示のようにしたことにより、液体の大部分が第１の吸収材５に吸収され、液体の無駄がなくなる。   In addition, since the shape of the bottom 31 of the liquid container 4 is as shown in the figure, most of the liquid is absorbed by the first absorbent 5 and the waste of the liquid is eliminated.

図４（ａ）ないし（ｄ）は、本発明の試験用具により免疫測定を実施するための吸収材の二つの例を示すもので、（ａ）および（ｂ）はその第１の例を示し、（ａ）は平面図で、（ｂ）は断面図である。また、（ｃ）および（ｄ）はその第２の例を示し、（ｃ）は平面図で、（ｄ）は断面図である。これらの図において、図６に示した従来のものと同一構成部分には同一符号を付してある。   4 (a) to 4 (d) show two examples of an absorbent material for performing an immunoassay with the test device of the present invention, and (a) and (b) show the first example. , (A) is a plan view and (b) is a cross-sectional view. Further, (c) and (d) show a second example, (c) is a plan view, and (d) is a cross-sectional view. In these drawings, the same components as those of the conventional one shown in FIG.

試験用具のケース本体１の中には、複数の吸収材の部材で構成された部材が装着されている。これらの複数の部材は、ニトロセルロースメンブレン、濾紙、不織布等を所定の長さに裁断した後、それぞれ重ね合わせることにより試験用具の吸収材を構成している。
本発明の試験用具では、前記の通り、押圧部材２１により押し下げられるシールブレーカー９と第１の吸収材５が、シールブレーカー９に設けられた破断突起２９に近接するが、接触しないよう位置決めすることが効率よく試験を実施するためには好ましい。 In the case body 1 of the test tool, a member composed of a plurality of absorbent members is mounted. The plurality of members constitute an absorbent material for a test tool by cutting a nitrocellulose membrane, filter paper, nonwoven fabric or the like into a predetermined length and then superposing them.
In the test tool of the present invention, as described above, the seal breaker 9 and the first absorbent 5 that are pushed down by the pressing member 21 are positioned close to the fracture protrusion 29 provided on the seal breaker 9 but not in contact with each other. Is preferable for conducting the test efficiently.

そこで、図４（ａ）ないし（ｄ）に示す通り、試験用具で用いられる複数の部材は、水不溶性のシート２６上の所定の位置に貼り付け固定することが好ましい。
水不溶性のシート２６としては、ポリエチレン、ポリプロピレン、ポリスチレン等の熱可塑性樹脂シート、水不透過性のコート紙等を用いることが好ましい。
シート２６は、図４（ａ）に示す通り、複数の吸収材と同一の幅であっても、図４（ｃ）に示す通り、吸収剤よりも広い幅であってもよい。複数の吸収材をシート２６へ固定するためには、展開速度、検査に影響を及ぼさない接着剤を用いるか、また、固定用の針などを用いることができる。 Therefore, as shown in FIGS. 4A to 4D, the plurality of members used in the test tool are preferably attached and fixed at predetermined positions on the water-insoluble sheet 26.
As the water-insoluble sheet 26, it is preferable to use a thermoplastic resin sheet such as polyethylene, polypropylene or polystyrene, a water-impermeable coated paper, or the like.
The sheet 26 may have the same width as the plurality of absorbent materials as shown in FIG. 4A, or may be wider than the absorbent as shown in FIG. 4C. In order to fix the plurality of absorbent materials to the sheet 26, an adhesive that does not affect the developing speed and the inspection can be used, or a fixing needle or the like can be used.

さらに、図４（ａ）ないし（ｄ）に示す通り、上記方法により作成したシート２６の第４の吸収材８側の端部には、ケース本体１に設けた突起（図示せず）と係合する開口３７を設けることことができる。この開口３７によって、ケース本体１への複数の吸収材の部材についての位置決めが容易となり、製造工程の改善とともに、シールブレーカー９と第１の吸収材５とが位置決めされた再現性のよい性能を有する試験用具を作製することができる。   Further, as shown in FIGS. 4A to 4D, a protrusion (not shown) provided on the case body 1 is engaged with the end of the sheet 26 prepared by the above method on the fourth absorbent material 8 side. A mating opening 37 can be provided. This opening 37 facilitates positioning of the members of the plurality of absorbent members to the case main body 1 and improves the manufacturing process, and has a highly reproducible performance in which the seal breaker 9 and the first absorbent member 5 are positioned. A test tool can be produced.

本発明の試験用具における要部の例を示すもので、使用前の状態を示す概略断面図である。The example of the principal part in the test tool of this invention is shown, and it is a schematic sectional drawing which shows the state before use. 図１のＩＩ−ＩＩ線で断面視した縦断面図である。FIG. 2 is a longitudinal sectional view taken along line II-II in FIG. 1. 本発明の試験用具における使用後の状態を示す概略断面図である。It is a schematic sectional drawing which shows the state after use in the test tool of this invention. 本発明の試験用具の吸収材の組合せ例を示す図面である。It is drawing which shows the example of a combination of the absorber of the test tool of this invention. 従来の試験用具を示す上平面図である。It is an upper top view which shows the conventional test tool. 従来の試験用具を示す図５のＩＩ−ＩＩ′線で切断した縦断面図である。It is the longitudinal cross-sectional view cut | disconnected by the II-II 'line | wire of FIG. 5 which shows the conventional test tool. 従来の試験用具におけるシールブレイカーを示す概略断面図である。It is a schematic sectional drawing which shows the seal breaker in the conventional test tool. 従来の試験用具におけるシールブレイカーの動作を示す説明図である。It is explanatory drawing which shows operation | movement of the seal breaker in the conventional test tool.

符号の説明Explanation of symbols

１・・・ケース本体、２・・・蓋部、３・・・シール部材、４・・・液体容器、５・・・第１の吸収材、６・・・第２の吸収材、９・・・シールブレイカー、２１・・・押圧部材、２２・・・破断片、２３Ａ・・・壁部、２４・・・屋根部、２５・・・係合凹部、２９・・・破断突起、３０・・・係合凸部。 DESCRIPTION OF SYMBOLS 1 ... Case main body, 2 ... Cover part, 3 ... Seal member, 4 ... Liquid container, 5 ... 1st absorber, 6 ... 2nd absorber, 9 ..Seal breaker, 21 ... Pressing member, 22 ... fragment, 23A ... wall, 24 ... roof, 25 ... engaging recess, 29 ... breaking projection, 30 ..Engaging protrusions

Claims (3)

ケース本体と、このケース本体を覆う蓋部とからなり、
ケース本体には、シール部材で密閉された液体容器と、この液体容器のシール部材上に載置された第１の吸収材が設けられており、
蓋部には、シールブレイカーが形成されており、
上記蓋部は、そのシールブレイカーが第１の吸収材上に位置するようにしてケース本体に取り付けられ、
上記シールブレイカーは、破断片と、この破断片を覆うようにして設けられた押圧部材を備えており、
上記破断片は、押圧部材に押圧されて上記液体容器のシール部材を直接破るとともに上記第１の吸収材を液体容器中の液体に浸すものであることを特徴とする試験用具。 It consists of a case body and a lid that covers this case body.
The case body is provided with a liquid container sealed with a sealing member and a first absorbent material placed on the sealing member of the liquid container,
A seal breaker is formed on the lid,
The lid is attached to the case body so that the seal breaker is positioned on the first absorbent material,
The seal breaker includes a broken piece and a pressing member provided so as to cover the broken piece,
The test tool according to claim 1, wherein the broken piece is pressed by the pressing member to directly break the sealing member of the liquid container and immerses the first absorbent in the liquid in the liquid container. 上記押圧部材は、壁部とこの壁部に連設された片流れ状の屋根部を有し、屋根部の下部が上記蓋部に対して回動可能に取り付けられ、壁部の下部が蓋部に対して離脱可能に取り付けられ、
上記破断片は、板状であって、その長手方向の一端部のみが蓋部に対して対して回動可能に取り付けられ、その長手方向の他端部には破断突起が設けられ、この破断突起が上記第１の吸収材の外方に位置するように設けられていることを特徴とする請求項１記載の試験用具。 The pressing member has a wall portion and a single-flow roof portion provided continuously to the wall portion, a lower portion of the roof portion is rotatably attached to the lid portion, and a lower portion of the wall portion is a lid portion. It is attached detachably with respect to
The broken piece is plate-shaped, and only one end portion in the longitudinal direction thereof is rotatably attached to the lid portion, and a breaking protrusion is provided at the other end portion in the longitudinal direction. The test tool according to claim 1, wherein the protrusion is provided so as to be located outside the first absorbent material. 上記押圧部材の壁部には、係合凹部が形成され、上記蓋部には、この係合凹部に離脱可能に係止する係合凸部が設けられており、
押圧部材を押圧しない状態では、上記係合凸部と上記係合凹部が互いに係合して押圧部材が蓋部から上方に突出した状態になっており、
押圧部材を押圧したあとの状態では、上記壁部の上部が上記係合凸部に係止され、押圧前の元の位置に復帰できないようになっていることを特徴とする請求項２記載の試験用具。

An engagement recess is formed in the wall portion of the pressing member, and an engagement protrusion that is releasably locked in the engagement recess is provided in the lid.
In a state where the pressing member is not pressed, the engaging convex portion and the engaging concave portion are engaged with each other, and the pressing member protrudes upward from the lid portion,
The upper part of the said wall part is latched by the said engagement convex part in the state after pressing a press member, It cannot prevent returning to the original position before a press. Test tool.

JP2005252137A 2005-08-31 2005-08-31 Testing tool Withdrawn JP2007064829A (en)

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