JP2007061281A - Inhalation amount measurement system - Google Patents

Inhalation amount measurement system Download PDF

Info

Publication number
JP2007061281A
JP2007061281A JP2005249480A JP2005249480A JP2007061281A JP 2007061281 A JP2007061281 A JP 2007061281A JP 2005249480 A JP2005249480 A JP 2005249480A JP 2005249480 A JP2005249480 A JP 2005249480A JP 2007061281 A JP2007061281 A JP 2007061281A
Authority
JP
Japan
Prior art keywords
inhalation
resistor
flow
subject
inhaler
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2005249480A
Other languages
Japanese (ja)
Inventor
Kazunori Ishizeki
一則 石関
Hisatomo Oki
久朝 大木
Shigemi Nakamura
茂巳 中村
Toyoko Okada
豊子 岡田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hitachi Ltd
Original Assignee
Hitachi Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi Ltd filed Critical Hitachi Ltd
Priority to JP2005249480A priority Critical patent/JP2007061281A/en
Publication of JP2007061281A publication Critical patent/JP2007061281A/en
Pending legal-status Critical Current

Links

Images

Landscapes

  • Measuring Volume Flow (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

<P>PROBLEM TO BE SOLVED: To obtain an inhalation amount measurement system which can perform a suitable inhalation treatment by grasping the actual inhalation amount by a subject. <P>SOLUTION: The actual inhalation amount by the subject can be grasped without using an actually employed inhaler and medicaments, etc. by using an inhalation resistor 1 which gives circulation resistance equal to circulation resistance in the inhaler to air stream produced by the inspiration of the subject, a flowmeter 2 which measures the flow rate of the air stream, and the inhalation amount measurement system equipped with an output unit which outputs the measurement result of the flowmeter 2. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

本発明は、吸入量測定システムに関する。   The present invention relates to an inhalation amount measuring system.

従来、喘息等の治療においては吸入治療が行われており、その吸入治療で使用されるドライパウダー吸入器として特許文献1に開示されるものが知られている。   Conventionally, inhalation therapy has been performed in the treatment of asthma and the like, and a dry powder inhaler used in the inhalation therapy is disclosed in Patent Document 1.

この特許文献1に開示されるドライパウダー吸入器を用いた吸入治療方法では、患者がドライパウダー吸入器の吸入口をくわえ息を吸い込むことで、ドライパウダー吸入器に装填された粉末状薬剤が空気と攪拌されて肺内に吸入される。
特開平9−262295号公報
In the inhalation treatment method using the dry powder inhaler disclosed in Patent Document 1, the patient inhales inhalation through the inhalation port of the dry powder inhaler, so that the powdery medicine loaded in the dry powder inhaler is air. And inhaled into the lungs.
JP-A-9-262295

ドライパウダー吸入器で粉末状薬剤を空気と攪拌させるには、ある程度強く息を吸い込んで、速い空気流を生じさせる必要がある。ここで、粉末状薬剤を空気と攪拌するために必要な吸入量は、吸入する薬剤の種類や量、吸入器の構造等によっても異なる。また、呼吸器疾患等の患者は吸気流速が低くなって、薬剤をうまく吸入できないおそれもある。   In order to agitate powdered medicine and air with a dry powder inhaler, it is necessary to inhale a certain amount of air and generate a fast air flow. Here, the inhalation amount necessary for stirring the powdered medicine with air varies depending on the type and amount of the medicine to be inhaled, the structure of the inhaler, and the like. In addition, patients with respiratory illness and the like may have a low inspiratory flow rate and may not be able to inhale the drug well.

しかし、従来は、粉末状薬剤を空気と攪拌させるのに十分な吸入量で吸入が行われているのか否かを確認することは行われていなかった。   However, conventionally, it has not been confirmed whether or not the inhalation is performed with a sufficient amount of inhalation for stirring the powdered medicine with air.

そこで、本発明は、被験者による実際の吸入量を把握して、より適切な吸入治療を行うことができるようにするための吸入量測定システムを得ることを目的とする。   Therefore, an object of the present invention is to obtain an inhalation amount measuring system for grasping an actual inhalation amount by a subject and performing a more appropriate inhalation treatment.

請求項1の発明にあっては、吸入量測定システムにおいて、被験者の吸気によって生じた空気流に、吸入器における流通抵抗と同等の流通抵抗を与える吸入抵抗器と、前記空気流の流量を測定する流量計と、前記流量計の測定結果を出力する出力装置とを備えることを特徴としている。   According to the first aspect of the present invention, in the inhalation amount measuring system, an inhalation resistor that provides a flow resistance equivalent to the flow resistance in the inhaler to the air flow generated by the inhalation of the subject, and the flow rate of the air flow is measured. And an output device for outputting a measurement result of the flow meter.

請求項2の発明にあっては、請求項1に記載の吸入量測定システムにおいて、前記出力装置は、流量の測定結果とともに参照値を出力することを特徴としている。   According to a second aspect of the present invention, in the inhalation amount measuring system according to the first aspect, the output device outputs a reference value together with a flow rate measurement result.

請求項3の発明にあっては、請求項1または請求項2に記載の吸入量測定システムにおいて、前記吸入抵抗器の流通抵抗を可変設定できるようにしたことを特徴としている。   The invention of claim 3 is characterized in that, in the inhalation amount measuring system according to claim 1 or 2, the flow resistance of the inhalation resistor can be variably set.

請求項1の発明によれば、実際の吸入治療に使用される吸入器や薬剤等を用いることなく、上記吸入抵抗器を用いて被験者の実際の吸入量を測定することができる。   According to the first aspect of the present invention, the actual inhalation amount of the subject can be measured using the inhalation resistor without using an inhaler or a medicine used for actual inhalation treatment.

請求項2の発明によれば、出力装置によって流量の測定結果とともに参照値が出力されるため、被験者の吸入量の過不足を容易に把握することができる。   According to the invention of claim 2, since the reference value is output together with the flow rate measurement result by the output device, it is possible to easily grasp whether the inhalation amount of the subject is excessive or insufficient.

請求項3の発明によれば、吸入抵抗器に複数の異なる吸入器の流通抵抗と同等の流通抵抗を与えることができるため、被験者に対してより適切な吸入器を選択することができるようになる。   According to the invention of claim 3, since the flow resistance equivalent to the flow resistance of a plurality of different inhalers can be given to the inhalation resistor, a more appropriate inhaler can be selected for the subject. Become.

以下、本発明の実施形態について図面を参照しながら詳細に説明する。図1は、本発明の実施形態にかかる吸入量測定システムの一構成例を示す図、図2は、本発明の実施形態にかかる吸入抵抗器の断面図、図3は、一被験者が吸入量を測定した結果の一出力例を示す図、図4は、一被験者が再度測定した結果の一出力例を示す図である。   Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. FIG. 1 is a diagram showing a configuration example of an inhalation amount measuring system according to an embodiment of the present invention, FIG. 2 is a cross-sectional view of an inhalation resistor according to an embodiment of the present invention, and FIG. FIG. 4 is a diagram illustrating an output example of a result of measurement by one subject again.

本実施形態における吸入量測定システムは、図1に示すように、被験者の吸気によって生じた空気流に、治療で実際に使用する吸入器における流通抵抗と同等の流通抵抗を与える吸入抵抗器1と、当該吸入抵抗器1に装着されて空気流の流量を測定する流量計2と、当該流量計2によって測定された流量信号の出力先を切り替える端子台3と、流量信号を演算処理装置5に入力するためのインタフェース装置4と、当該流量信号に基づいて所定の演算処理を行う演算処理装置5とを備えるものである。   As shown in FIG. 1, the inhalation amount measuring system according to the present embodiment includes an inhalation resistor 1 that gives a flow resistance equivalent to the flow resistance in an inhaler actually used for treatment to an air flow generated by inhalation of a subject. A flow meter 2 mounted on the suction resistor 1 for measuring the flow rate of the air flow, a terminal block 3 for switching an output destination of the flow rate signal measured by the flow meter 2, and the flow rate signal to the arithmetic processing unit 5 The interface apparatus 4 for inputting and the arithmetic processing apparatus 5 which performs a predetermined arithmetic processing based on the said flow rate signal are provided.

吸入抵抗器1は、流量計2に装着される基体部6と、空気流に流通抵抗を付与する抵抗体8と、抵抗体8を基体部6に装着するためのキャップ7および押さえナット9と、を備えてなるものである。また、抵抗体8を基体部6に装着すると、当該基体部6の通気孔6eと抵抗体8の内部通路8aとが略一直線上に配列され、一連の空気通路が形成される。   The suction resistor 1 includes a base portion 6 attached to the flow meter 2, a resistor 8 that imparts flow resistance to the air flow, a cap 7 and a presser nut 9 for attaching the resistor 8 to the base portion 6, , Is provided. Further, when the resistor 8 is mounted on the base portion 6, the air holes 6e of the base portion 6 and the internal passage 8a of the resistor 8 are arranged on a substantially straight line, thereby forming a series of air passages.

基体部6の空気通路の軸方向の一端側には、雄ネジ部6aが突設されており、当該雄ネジ部6aを流量計2の雌ネジ孔(図示せず)に螺結することで吸入抵抗器1が流量計2に装着される。一方、他端側の外周には押さえナット9を螺結する雄ネジ6bが形成されている。また、他端側の端面6cには抵抗体8を嵌挿する円形断面の凹部6dが設けられている。   A male threaded portion 6a protrudes from one end of the air passage of the base body 6 in the axial direction, and the male threaded portion 6a is screwed into a female threaded hole (not shown) of the flowmeter 2. A suction resistor 1 is attached to the flow meter 2. On the other hand, a male screw 6b for screwing the holding nut 9 is formed on the outer periphery on the other end side. Further, a recess 6d having a circular cross section into which the resistor 8 is inserted is provided on the end face 6c on the other end side.

キャップ7は、有底円筒状の筒状部7aと該筒状部7aの開口縁に形成された円環状のフランジ部7bとを備える。また、筒状部7aの底壁部7cには貫通孔7dが形成されている。   The cap 7 includes a cylindrical portion 7a having a bottomed cylindrical shape and an annular flange portion 7b formed at the opening edge of the cylindrical portion 7a. A through hole 7d is formed in the bottom wall portion 7c of the cylindrical portion 7a.

押さえナット9は、有底円筒状に形成されており、その底壁部9aには貫通孔9bが形成されている。   The holding nut 9 is formed in a bottomed cylindrical shape, and a through-hole 9b is formed in the bottom wall portion 9a.

本実施形態では、この押さえナット9を用いて抵抗体8およびキャップ7を基体部6に取り付けている。具体的には、基体部6の端面6cに形成した凹部6dに略円筒状の抵抗体8を嵌挿して当該端面6cから突き出させ、その端面6cにフランジ部7bを対向させるとともに、当該端面6cから突き出させた抵抗体8に筒状部7aを被せる。そして、押さえナット9を、その貫通孔9bに抵抗体8および筒状部7aを挿通させた状態で雄ネジ6bに螺結し、底壁部9aの内面でフランジ部7bを端面6c側に押し付け、以て、抵抗体8を凹部6dの奥側に押し込んでいる。   In the present embodiment, the resistor 8 and the cap 7 are attached to the base body 6 using the presser nut 9. Specifically, a substantially cylindrical resistor 8 is inserted into a recess 6d formed in the end surface 6c of the base portion 6 so as to protrude from the end surface 6c, the flange portion 7b is opposed to the end surface 6c, and the end surface 6c. The cylindrical portion 7a is placed on the resistor 8 protruding from the tube. The holding nut 9 is screwed to the male screw 6b with the resistor 8 and the cylindrical portion 7a being inserted through the through hole 9b, and the flange portion 7b is pressed to the end surface 6c side with the inner surface of the bottom wall portion 9a. Thus, the resistor 8 is pushed into the back side of the recess 6d.

かかる構成によれば、押さえナット9の着脱によって抵抗体8を交換することができる。したがって、内部通路8aの形状や狭窄部8bの径や長さ等の異なる抵抗体8を複数種類準備しておき、これらを適宜に交換して装着することで、吸入抵抗器1の流通抵抗を可変設定することができる。   According to this configuration, the resistor 8 can be replaced by attaching and detaching the presser nut 9. Therefore, by preparing a plurality of types of resistors 8 having different shapes such as the shape of the internal passage 8a and the diameter and length of the narrowed portion 8b, and replacing them appropriately, the flow resistance of the suction resistor 1 can be reduced. Can be variably set.

このとき、各抵抗体8を装着した場合の吸入抵抗器1の空気抵抗を、治療で実際に使用する各吸入器の空気抵抗とあわせておくことで、当該吸入抵抗器1によって、吸入器による吸入のシミュレーションを行うことができる。   At this time, by combining the air resistance of the inhalation resistor 1 when each resistor 8 is mounted with the air resistance of each inhaler actually used in treatment, the inhalation resistor 1 causes the inhaler to Inhalation simulation can be performed.

上記吸入抵抗器1が装着された流量計2は、本実施形態においては、端子台3の入力端子3aに接続コード2aを介して接続されている。この端子台3には複数の流量計2を接続することができる。図1の例では、入力端子3aおよび出力端子3bがそれぞれ6つずつ備えられており、入力端子3aと出力端子3bとの接続関係を適宜に切り替えることができるように構成されている。そして、出力端子3bには、接続コード4aを介してインタフェース装置4が接続されており、当該インタフェース装置4が、演算処理装置5に接続されている。演算処理装置5としてはコンピュータを用いることができる。   In the present embodiment, the flow meter 2 to which the suction resistor 1 is attached is connected to the input terminal 3a of the terminal block 3 via a connection cord 2a. A plurality of flow meters 2 can be connected to the terminal block 3. In the example of FIG. 1, six input terminals 3a and six output terminals 3b are provided, respectively, so that the connection relationship between the input terminals 3a and the output terminals 3b can be appropriately switched. The interface device 4 is connected to the output terminal 3b via a connection cord 4a, and the interface device 4 is connected to the arithmetic processing device 5. A computer can be used as the arithmetic processing unit 5.

以上の構成による本実施形態において、複数種類の抵抗体8の1つを吸入抵抗器1に取り付けた状態で、被験者がキャップ7をくわえて息を吸い込む。こうして吸入抵抗器1内に生じた空気流が、流量計2によって計測される。そして、流量計2によって計測された流量信号は、端子台3を経由してインタフェース装置4へ送られ、演算処理装置5で処理可能な形態に変換されて当該演算処理装置5に入力される。   In the present embodiment having the above-described configuration, the subject inhales while holding the cap 7 with one of the plurality of types of resistors 8 attached to the inhalation resistor 1. Thus, the air flow generated in the suction resistor 1 is measured by the flow meter 2. The flow rate signal measured by the flow meter 2 is sent to the interface device 4 via the terminal block 3, converted into a form that can be processed by the arithmetic processing device 5, and input to the arithmetic processing device 5.

演算処理装置5では、入力された流量信号に基づいて所定の演算処理が実行される。本実施形態においては、演算処理装置5としてのコンピュータのディスプレイ5aに、測定された流量の経時変化がグラフ化されて表示される。また、測定結果とともに参照値Rも表示される。本実施形態においては、この参照値Rとして、抵抗体8に対応する吸入器において粉末状薬剤を十分に攪拌するのに必要な流量が表示される。   The arithmetic processing unit 5 executes predetermined arithmetic processing based on the input flow rate signal. In the present embodiment, the change over time of the measured flow rate is displayed as a graph on the display 5a of the computer as the arithmetic processing unit 5. A reference value R is also displayed together with the measurement result. In the present embodiment, as the reference value R, the flow rate necessary for sufficiently stirring the powdered medicine in the inhaler corresponding to the resistor 8 is displayed.

以下、本実施形態にかかる吸入量測定システムを用いて行った測定結果の一例を示す。   Hereinafter, an example of the measurement result performed using the inhalation amount measurement system according to the present embodiment will be shown.

図3、図4には、一被験者が本実施形態にかかる吸入量測定システムを用いて測定を行った結果が示されている。図3および図4において、横軸は時間、縦軸は流量である。   FIG. 3 and FIG. 4 show the results of measurement performed by one subject using the inhalation amount measuring system according to the present embodiment. 3 and 4, the horizontal axis represents time, and the vertical axis represents flow rate.

図3をみると、被験者の最初の吸入では、測定結果が参照値Rを超えておらず、流量が粉末状薬剤を十分に攪拌するのに必要な流量を下回り、吸入が不十分であることがわかる。   As shown in FIG. 3, in the first inhalation of the subject, the measurement result does not exceed the reference value R, the flow rate is lower than the flow rate necessary for sufficiently stirring the powdered drug, and the inhalation is insufficient. I understand.

次に、図4をみると、被験者の二度目の吸入では、測定結果が参照値Rを超えており、流量が粉末状薬剤を十分に攪拌するのに必要な流量を上回り、吸入が十分であることがわかる。   Next, referring to FIG. 4, in the second inhalation of the subject, the measurement result exceeds the reference value R, the flow rate exceeds the flow rate necessary to sufficiently stir the powdered drug, and the inhalation is sufficient. I know that there is.

このように、本実施形態によれば、被験者が吸入量測定を行った際に、その結果とともに粉末状薬剤を十分に攪拌するのに必要な流量が参照値Rとしてディスプレイ5a上に表示されるため、被験者による吸入量の過不足を容易に判断することができる。   Thus, according to the present embodiment, when the subject measures the inhalation amount, the flow rate necessary for sufficiently stirring the powdered medicine is displayed on the display 5a as the reference value R together with the result. Therefore, it is possible to easily determine whether the inhalation amount is excessive or insufficient by the subject.

以上の本実施形態によれば、実際の吸入治療に使用される吸入器とほぼ同等の負荷を与える吸入抵抗器1を用いて吸入した場合の流量を計測することができるため、被験者が実際に吸入治療に使用する吸入器を用いた場合とほぼ同等の吸入量を、本吸入抵抗器1を使用して測定することができる。したがって、被験者は実際の吸入器や薬剤等を用いることなく吸入の訓練を行うことができる。また、本実施形態にかかる吸入量測定システムを、吸入器の評価や開発等に供することも可能である。   According to the present embodiment described above, the flow rate when inhaled can be measured using the inhalation resistor 1 that gives a load substantially equivalent to that of the inhaler used in actual inhalation therapy. An inhalation amount substantially equivalent to that when using an inhaler used for inhalation therapy can be measured using the inhalation resistor 1. Therefore, the subject can perform inhalation training without using an actual inhaler or medicine. In addition, the inhalation amount measurement system according to the present embodiment can be used for evaluation and development of an inhaler.

また、本実施形態によれば、コンピュータ等の演算処理装置5のディスプレイ5aには、流量の測定結果とともに参照値Rも出力されるため、被験者の吸入量の過不足を把握することができる。したがって、被験者はより効率的に吸入の訓練を行うことができる。   Further, according to the present embodiment, since the reference value R is output together with the flow rate measurement result on the display 5a of the arithmetic processing unit 5 such as a computer, it is possible to grasp whether the inhalation amount of the subject is excessive or insufficient. Accordingly, the subject can perform inhalation training more efficiently.

また、本実施形態によれば、抵抗体8を交換することで吸入抵抗器1に様々な流通抵抗を付与できるようにしたため、種々の流通抵抗を可変設定できる吸入抵抗器を、比較的簡素な構成として得ることができる。また、様々な抵抗値を有する抵抗体8を使用して吸入量を測定することで、被験者に対してより適切な吸入器を選択することができるようになる。さらに、大人や子供など様々な被験者の吸気量を計測することで、吸入治療用の吸入器をより適したものとするための吸入器開発等も可能となる。   Further, according to the present embodiment, since various flow resistances can be imparted to the suction resistor 1 by exchanging the resistor 8, the suction resistor that can variably set various flow resistances is relatively simple. It can be obtained as a configuration. Further, by measuring the amount of inhalation using the resistor 8 having various resistance values, a more appropriate inhaler can be selected for the subject. Furthermore, by measuring the amount of inhalation of various subjects such as adults and children, it becomes possible to develop an inhaler for making the inhaler for inhalation therapy more suitable.

また、本実施形態においては、端子台3に流通抵抗の異なる吸入抵抗器1を装着した複数の流量計2を接続し、当該端子台3で、流量信号を取得する流量計2を容易に切り替えることができるため、被験者が吸入治療を行うのに適切な吸入器をより効率的に選択させることができる。また、複数の被験者の吸入に伴う流量測定を一度に行うことができるため、吸入器開発や臨床試験等の効率化が可能となる。   Further, in the present embodiment, a plurality of flow meters 2 equipped with suction resistors 1 having different flow resistances are connected to the terminal block 3, and the flow meter 2 for acquiring a flow signal is easily switched by the terminal block 3. This allows the subject to more efficiently select an appropriate inhaler for performing inhalation therapy. In addition, since flow measurement associated with inhalation of a plurality of subjects can be performed at one time, it is possible to improve the efficiency of inhaler development and clinical trials.

なお、本発明は、次のような別の実施形態に具現化することができる。以下の別の実施形態でも、上記実施形態と同様の作用および効果を得ることができる。   The present invention can be embodied in another embodiment as follows. In other embodiments described below, the same operations and effects as those of the above-described embodiment can be obtained.

(1)上記実施形態においては、演算処理装置に出力される測定結果は、グラフに表されているが、測定結果を判断することができる限りグラフ化する必要はなく、例えば最大流量や参照値を数値で表示してもよい。   (1) In the above embodiment, the measurement result output to the arithmetic processing unit is represented in a graph, but it is not necessary to graph as long as the measurement result can be determined. For example, the maximum flow rate or the reference value May be displayed numerically.

(2)上記実施形態においては、測定結果や参照値を表示出力しているが、これに替えて、例えば、プリンタによって測定結果や参照値を印刷出力したり、スピーカによって測定結果や参照値を音声出力したりしてもよい。   (2) In the above embodiment, the measurement result and the reference value are displayed and output. Instead, for example, the measurement result and the reference value are printed out by a printer, or the measurement result and the reference value are output by a speaker. Sound output may be performed.

(3)上記実施形態においては、コンピュータのディスプレイに参照値として粉末状薬剤を十分に攪拌するのに必要な流量を表示しているが、他の値を参照値として使用してもよいし、複数の参照値を出力してもよい。   (3) In the above embodiment, the flow rate necessary to sufficiently agitate the powdered medicine is displayed as a reference value on the computer display, but other values may be used as the reference value. A plurality of reference values may be output.

(4)上記実施形態においては、抵抗体を交換することで流通抵抗を変化させているが、これに替えて、例えば抵抗体の内部通路の断面積の大きさを調節可能な可変絞り機構(例えば虹彩絞り)を設ける等して流通抵抗を変化させてもよい。   (4) In the above embodiment, the flow resistance is changed by exchanging the resistor, but instead, for example, a variable throttle mechanism that can adjust the size of the cross-sectional area of the internal passage of the resistor ( For example, the flow resistance may be changed by providing an iris diaphragm.

(5)吸入抵抗器の形状も吸入器における流通抵抗と同等の流通抵抗を与えることができる限り種々の形状をとり得る。   (5) The shape of the suction resistor can take various shapes as long as it can provide a flow resistance equivalent to the flow resistance in the inhaler.

(6)上記実施形態においては、測定結果の表示をコンピュータ等の出力装置で行っているが、流量計に測定結果を表示させるように構成してもよい。   (6) In the above embodiment, the measurement result is displayed by an output device such as a computer. However, the measurement result may be displayed on a flow meter.

また、上記実施形態から把握しうる請求項以外の技術的思想について、以下にその効果と共に記載する。   Further, technical ideas other than the claims that can be grasped from the above embodiment will be described together with the effects thereof.

(イ)請求項3に記載の吸入量測定システムでは、流通抵抗の異なる抵抗体を交換して装着することで吸入抵抗器の流通抵抗を可変設定できるようにするのが好適である。   (A) In the inhalation amount measuring system according to claim 3, it is preferable that the circulation resistance of the inhalation resistor can be variably set by exchanging and mounting resistors having different circulation resistances.

こうすれば、種々の流通抵抗を可変設定できる吸入抵抗器を、比較的簡素な構成として得ることができる。   In this way, it is possible to obtain a suction resistor capable of variably setting various flow resistances with a relatively simple configuration.

本発明の実施形態にかかる吸入量測定システムの一構成例を示す図。The figure which shows the example of 1 structure of the inhalation | amount measurement system concerning embodiment of this invention. 本発明の実施形態にかかる吸入量測定システムに含まれる吸入抵抗器の断面図。Sectional drawing of the inhalation resistor contained in the inhalation amount measuring system concerning embodiment of this invention. 一被験者が本実施形態にかかる吸入量測定システムによって吸入量を測定した結果の一出力例を示す図。The figure which shows one output example as a result of one test subject measuring the inhalation amount by the inhalation amount measuring system concerning this embodiment. 一被験者が本実施形態にかかる吸入量測定システムによって再度測定した結果の一出力例を示す図。The figure which shows one output example as a result of one test subject measuring again by the inhalation amount measuring system concerning this embodiment.

符号の説明Explanation of symbols

1 吸入抵抗器
2 流量計
5 演算処理装置(出力装置)
R 参照値
1 Inhalation resistor 2 Flow meter 5 Arithmetic processing device (output device)
R reference value

Claims (3)

被験者の吸気によって生じた空気流に、吸入器における流通抵抗に対応する流通抵抗を与える吸入抵抗器と、
前記空気流の流量を測定する流量計と、
前記流量計の測定結果を出力する出力装置とを備えることを特徴とする吸入量測定システム。
An inhalation resistor that provides a flow resistance corresponding to the flow resistance in the inhaler to the air flow generated by the subject's inhalation;
A flow meter for measuring the flow rate of the air flow;
An inhalation amount measuring system comprising: an output device that outputs a measurement result of the flow meter.
前記出力装置は、流量の測定結果とともに参照値を出力することを特徴とする請求項1に記載の吸入量測定システム。   The inhalation amount measuring system according to claim 1, wherein the output device outputs a reference value together with a flow rate measurement result. 前記吸入抵抗器の流通抵抗を可変設定できるようにしたことを特徴とする請求項1または請求項2に記載の吸入量測定システム。   The inhalation amount measuring system according to claim 1 or 2, wherein a flow resistance of the inhalation resistor can be variably set.
JP2005249480A 2005-08-30 2005-08-30 Inhalation amount measurement system Pending JP2007061281A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2005249480A JP2007061281A (en) 2005-08-30 2005-08-30 Inhalation amount measurement system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005249480A JP2007061281A (en) 2005-08-30 2005-08-30 Inhalation amount measurement system

Publications (1)

Publication Number Publication Date
JP2007061281A true JP2007061281A (en) 2007-03-15

Family

ID=37924182

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2005249480A Pending JP2007061281A (en) 2005-08-30 2005-08-30 Inhalation amount measurement system

Country Status (1)

Country Link
JP (1) JP2007061281A (en)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013514818A (en) * 2009-11-03 2013-05-02 マンカインド コーポレ−ション Apparatus and method for simulating inhalation activity
US8909487B2 (en) 2009-03-11 2014-12-09 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US9041925B2 (en) 2009-03-18 2015-05-26 Mannkind Corporation Laser diffraction with inhaler enclosed in positive pressure chamber
US9339615B2 (en) 2008-06-13 2016-05-17 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9346766B2 (en) 2004-08-20 2016-05-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9364436B2 (en) 2011-06-17 2016-06-14 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US9446001B2 (en) 2005-09-14 2016-09-20 Mannkind Corporation Increasing drug affinity for crystalline microparticle surfaces
US9610351B2 (en) 2011-10-24 2017-04-04 Mannkind Corporation Methods and compositions for treating pain
US9630930B2 (en) 2009-06-12 2017-04-25 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
US9655850B2 (en) 2008-12-29 2017-05-23 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9662461B2 (en) 2008-06-13 2017-05-30 Mannkind Corporation Dry powder drug delivery system and methods
US9675674B2 (en) 2004-08-23 2017-06-13 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US9700690B2 (en) 2002-03-20 2017-07-11 Mannkind Corporation Inhalation apparatus
US9801925B2 (en) 1999-06-29 2017-10-31 Mannkind Corporation Potentiation of glucose elimination
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
US9943571B2 (en) 2008-08-11 2018-04-17 Mannkind Corporation Use of ultrarapid acting insulin
US10130581B2 (en) 2006-02-22 2018-11-20 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10342938B2 (en) 2008-06-13 2019-07-09 Mannkind Corporation Dry powder drug delivery system
US10421729B2 (en) 2013-03-15 2019-09-24 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10625034B2 (en) 2011-04-01 2020-04-21 Mannkind Corporation Blister package for pharmaceutical cartridges
US10675421B2 (en) 2008-06-20 2020-06-09 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
JP2021048930A (en) * 2019-09-21 2021-04-01 トキコシステムソリューションズ株式会社 Inhalation amount measurement system
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods

Cited By (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9801925B2 (en) 1999-06-29 2017-10-31 Mannkind Corporation Potentiation of glucose elimination
US9700690B2 (en) 2002-03-20 2017-07-11 Mannkind Corporation Inhalation apparatus
US9796688B2 (en) 2004-08-20 2017-10-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9346766B2 (en) 2004-08-20 2016-05-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9675674B2 (en) 2004-08-23 2017-06-13 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US10130685B2 (en) 2004-08-23 2018-11-20 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US9717689B2 (en) 2005-09-14 2017-08-01 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US10143655B2 (en) 2005-09-14 2018-12-04 Mannkind Corporation Method of drug formulation
US9446001B2 (en) 2005-09-14 2016-09-20 Mannkind Corporation Increasing drug affinity for crystalline microparticle surfaces
US10130581B2 (en) 2006-02-22 2018-11-20 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US9339615B2 (en) 2008-06-13 2016-05-17 Mannkind Corporation Dry powder inhaler and system for drug delivery
US10751488B2 (en) 2008-06-13 2020-08-25 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9662461B2 (en) 2008-06-13 2017-05-30 Mannkind Corporation Dry powder drug delivery system and methods
US10342938B2 (en) 2008-06-13 2019-07-09 Mannkind Corporation Dry powder drug delivery system
US9511198B2 (en) 2008-06-13 2016-12-06 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9446133B2 (en) 2008-06-13 2016-09-20 Mannkind Corporation Dry powder inhaler and system for drug delivery
US10201672B2 (en) 2008-06-13 2019-02-12 Mannkind Corporation Dry powder inhaler and system for drug delivery
US10675421B2 (en) 2008-06-20 2020-06-09 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
US10046031B2 (en) 2008-08-11 2018-08-14 Mannkind Corporation Use of ultrarapid acting insulin
US9943571B2 (en) 2008-08-11 2018-04-17 Mannkind Corporation Use of ultrarapid acting insulin
US9655850B2 (en) 2008-12-29 2017-05-23 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US10172850B2 (en) 2008-12-29 2019-01-08 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9983108B2 (en) 2009-03-11 2018-05-29 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US8909487B2 (en) 2009-03-11 2014-12-09 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US9041925B2 (en) 2009-03-18 2015-05-26 Mannkind Corporation Laser diffraction with inhaler enclosed in positive pressure chamber
US9630930B2 (en) 2009-06-12 2017-04-25 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
US9016147B2 (en) 2009-11-03 2015-04-28 Mannkind Corporation Apparatus and method for simulating inhalation efforts
US9706944B2 (en) 2009-11-03 2017-07-18 Mannkind Corporation Apparatus and method for simulating inhalation efforts
JP2013514818A (en) * 2009-11-03 2013-05-02 マンカインド コーポレ−ション Apparatus and method for simulating inhalation activity
US10625034B2 (en) 2011-04-01 2020-04-21 Mannkind Corporation Blister package for pharmaceutical cartridges
US9364436B2 (en) 2011-06-17 2016-06-14 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US10130709B2 (en) 2011-06-17 2018-11-20 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US9610351B2 (en) 2011-10-24 2017-04-04 Mannkind Corporation Methods and compositions for treating pain
US10258664B2 (en) 2011-10-24 2019-04-16 Mannkind Corporation Methods and compositions for treating pain
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US10421729B2 (en) 2013-03-15 2019-09-24 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
JP2021048930A (en) * 2019-09-21 2021-04-01 トキコシステムソリューションズ株式会社 Inhalation amount measurement system

Similar Documents

Publication Publication Date Title
JP2007061281A (en) Inhalation amount measurement system
AU2008271709B2 (en) A gas mixing device for an air-way management system
EP3542869A1 (en) Disposable sleep and breathing monitor
EP3653247B1 (en) Determination of air flow rate through an inhaler
JPH0624529B2 (en) Device for sampling and analyzing exhaled breath and disposable gas sampling device
BRPI0914308B1 (en) INHALATION SYSTEM
JP4855803B2 (en) Respiratory function testing device
JP2018524047A (en) Resuscitation and ventilation monitors
JP5896609B2 (en) Respiratory function testing device
JP7390307B2 (en) Portable handheld electronic spirometer
WO2014171547A1 (en) Walking test device
CN115955986A (en) Respiratory shunt module and sharing system configured to connect multiple patients to a single ventilator with independent ventilation parameter control
CN109475708B (en) Device and method for monitoring compliance with inhalation therapy
AU2017319818B2 (en) Device for measuring respiratory parameters of a patient
KR20220029285A (en) Mouthpiece assembly for breathing device
JP7474758B2 (en) Modular vibration measurement device with dynamic calibration
JP7109534B2 (en) Spirometer Flow Sensing Arrangement
WO2017022429A1 (en) Breathing function examining instrument
CN113784743A (en) Breathing apparatus for providing bubble CPAP
JP7153440B2 (en) breathing exercise device
KR102062206B1 (en) Breathing measuring device with sensor connection
JP2009125567A (en) Information monitoring device in living body and monitoring method
JP2021035441A (en) Respiratory flow rate measurement apparatus
JP2006184265A (en) Oral odor measuring instrument and method, and odor measuring instrument and method
JP5886060B2 (en) Respiratory flow measurement device and calibration device