JP2002165878A - Blood storage tank - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a blood storage tank, in which damage to stored blood in reduced. SOLUTION: This blood storage tank 1' is provided with a box-shaped housing 2 and filtering and antifoaming devices 7b, 7c, and 7d respectively set inside the housing 2. The blood drawn from the main vein flows in to the filtering and antifoaming device 7b from a blood inflow port 5c, vent blood sucked from the heart flows in to the filtering and antifoaming device 7c from a blood inflow port 5a and sucked blood sucked from an operation field (other than the heart) flows in to the filtering and antifoaming device 7d from a blood inflow port 5b. The filter member 27 of the filtering and antifoaming device 7d filters foreign matters from the sucked blood. The vent blood passes through the filter member 22 of the filtering and antifoaming device 7c and enters a blood storage space 25 without being in contact with the foreign matters filtered from the sucked blood.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a blood reservoir.

[0002]

2. Description of the Related Art In cardiac surgery, for example, a blood pump is operated to bleed blood from a patient's vein (large vein), gas is exchanged by an artificial lung, and this blood is returned to the patient's artery. The artificial lung extracorporeal blood circulation is performed.

In the extracorporeal blood circulation of an artificial lung, in addition to a main circuit consisting of a blood removal line from the vena cava and a blood supply line to the artery, a suction circuit for sucking blood collected in the operative field and a suction circuit inside the heart. A vent circuit for aspirating the collected blood is provided.

In such a suction circuit and a vent circuit, the aspirated blood aspirated from the operative field (outside the heart) and the vent blood aspirated from the inside of the heart are stored in a blood reservoir for temporarily storing these bloods. (Cardiotomy Reservoir). A filter member is provided in the blood reservoir to filter foreign substances from the blood and remove bubbles in the blood. The blood filtered and defoamed in the blood reservoir is returned to the patient's body.
Such a blood reservoir also has a buffer function for adjusting the amount of blood in the circuit and keeping the amount of blood returned constant.

Among the blood flowing into the blood reservoir as described above, aspirated blood from outside the heart contains a relatively large amount of foreign substances such as fat globules, tissue fragments, denatured proteins, and aggregates other than blood. . On the other hand, vented blood from the heart usually has a low content of those foreign substances and is close to blood removed from the vena cava,
Less damaged blood.

[0006] In a conventional blood reservoir, aspirated blood from outside the heart and vent blood from the heart are merged in the blood reservoir and then filtered by the same filter member. For this reason, the vent blood, which has had little damage, comes into contact with the foreign matter filtered from the aspirated blood when passing through the filter member in the blood reservoir, and is activated by reacting with the foreign matter. There is.

[0007]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a blood reservoir that can reduce damage to stored blood.

[0008]

This and other objects are achieved by the present invention which is defined below as (1) to (11).

(1) A housing having a first inlet into which vent blood from the heart flows, a second inlet into which aspirated blood from outside the heart flows, and a blood outlet, and the inside of the housing. And a filter member for filtering the inflowing blood, wherein the vented blood flowing into the housing is configured to pass through the filter member without contacting the foreign matter filtered out from the aspirated blood. A blood reservoir.

(2) The first inflow port, which is in communication with the first inflow port, at least a part of which is defined by the filter member.
The blood reservoir according to the above (1), comprising: a filter chamber of (1), and a second filter chamber communicating with the second inflow port, at least a part of which is defined by the filter member.

(3) The first filter chamber and the second filter chamber are formed by partitioning a space surrounded by the same filter member by a partition.
The blood reservoir according to 1.

(4) The blood reservoir according to (2), wherein the first filter chamber and the second filter chamber are defined by separate filter members.

(5) The blood reservoir according to (4), wherein the filter member defining the first filter chamber and the filter member defining the second filter chamber have different conditions. Tank.

(6) The effective area of the filter member defining the first filter chamber is different from the effective area of the filter member defining the second filter chamber. The blood reservoir according to any one of the above.

(7) The blood reservoir according to any one of (1) to (6), further comprising defoaming means in which an antifoaming agent is carried on the filter member and / or the carrier.

(8) a defoaming agent carried on a filter member defining the first filter chamber and / or a carrier installed in the first filter chamber;
(7) having a filter member defining the filter chamber of (1) and / or an antifoaming agent supported on a carrier provided in the second filter chamber, wherein the total carrying amounts of both are different from each other. Blood reservoir.

(9) A first blood introduction tube for introducing blood from the first inlet to the first filter chamber, and blood is introduced from the second inlet to the second filter chamber. The blood reservoir according to any one of (2) to (8), further including a second blood introduction tube.

(10) The blood reservoir according to the above (9), wherein the first blood introduction tube extends below the second blood introduction tube.

(11) The housing has a third inflow port into which blood from the vena cava flows, communicates with the third inflow port, at least a part of which is defined by the filter member. The blood reservoir according to any one of (2) to (10), further including a third filter chamber.

[0020]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, a blood reservoir according to the present invention will be described in detail based on a preferred embodiment shown in the accompanying drawings.

<First Embodiment> FIG. 1 is a side view showing a first embodiment of a blood reservoir according to the present invention, and FIG. 2 is a sectional view taken on line AA in FIG.
3 is a cross-sectional view taken along line CC in FIG. 2,
FIG. 4 is a cross-sectional view taken along the line BB in FIG. 1, and FIG. 5 is a circuit diagram in the extracorporeal lung extracorporeal blood circulation.

The blood reservoir 1 shown in FIG. 1 temporarily stores blood removed from the vena cava, and temporarily stores aspirated blood from outside the heart and vented blood from the heart. A blood reservoir (cardiotomy reservoir) to be stored is integrated, and has a housing 2 composed of a housing body 3 and a lid 4. Inside the housing 2, a blood storage space 25 for storing blood is formed.

The housing body 3 has a box shape having a projecting portion 31 projecting downward on the left side in FIG.
A tubular blood outlet 6 communicating with the blood storage space 25 is formed below the protrusion 31.

The cover 4 is fitted to the upper end of the housing body 3 so as to cover the upper opening of the housing body 3.
At a predetermined position of the lid 4, a tubular blood inlet 5a,
5b and 5c are formed respectively.

Blood inlets 5a to 5c and blood outlet 6
Are connected in the artificial lung extracorporeal blood circulation circuit as follows.

As shown in FIG. 5, the blood inlet 5a (first
Is connected to a tube of a vent suction line 80. That is, blood (hereinafter, referred to as “vent blood”) sucked by the pump 82 from inside the heart (particularly the left atrium and left ventricle) flows into the blood inflow port 5a.
This vented blood is a blood which has a small content of foreign substances such as fat globules, tissue fragments, denatured proteins and aggregates other than blood, and is relatively less damaged. In addition, vented blood also has a relatively small amount of air bubbles.

The tube of the suction line 81 in the heart chamber (thoracic cavity) is connected to the blood inlet 5b (second inlet).
That is, blood (hereinafter, referred to as “aspirated blood”) sucked by the pump 83 from an operation field (outside the heart) such as in a heart cavity (thoracic cavity) flows into the blood inlet 5b. This aspirated blood has a relatively high content of foreign substances as described above. Further, the aspirated blood also contains a relatively large amount of air bubbles.

The tube of the blood removal line 84 is connected to the blood inlet 5c (third inlet). That is, the blood removed from the vena cava flows into the blood inlet 5c.

The blood that has flowed into the blood reservoir 1 from the blood inlets 5a to 5c flows out of the blood outlet 6 after foreign substances and bubbles have been removed by filtration and defoaming devices 7a and 7b, which will be described later.

The tube of the line connected to the oxygenator 86 is connected to the blood outlet 6. In the middle of this line, a blood pump 85 is installed.

The blood oxygenated by the oxygenator 86 is sent into the artery through the tube of the blood supply line 88. An arterial filter 87 is provided in the middle of the blood supply line.

As shown in FIG. 4, a priming liquid injection port 5d used for injecting a priming liquid into a filtration and defoaming device 7b described later is formed on the side of the blood inlet 5c.

A degassing port 5e is formed on the side of the blood inlet 5c opposite to the priming liquid inlet 5d. Some of the air bubbles broken by the filtering and defoaming devices 7a and 7b to be described later are discharged to the outside as air from the deaeration port 5e. In addition, the inflow and outflow of air accompanying the increase and decrease of blood in the blood reservoir 1 are performed through the deaeration port 5e.

In such a housing 2, the volume of the blood storage space 25 is not particularly limited. For example, about 3000 to 5000 ml for adults and about 1000 to 5000 ml for children.
Preferably, the volume is about 2500 ml.

The constituent materials of the housing body 3 and the cover 4 are, for example, polycarbonate, acrylic resin,
Polyethylene terephthalate, polyethylene, polypropylene, polystyrene, polyvinyl chloride, acryl-styrene copolymer, acryl-butadiene-styrene copolymer, etc., among which polycarbonate, acrylic resin, polystyrene, polyvinyl chloride Is preferred.

The housing body 3 and the lid 4 are
It is preferably substantially transparent so that the amount of stored blood and the state of blood inside can be visually checked.

A scale (not shown) indicating the amount of stored blood is provided on the front (left end face in FIG. 1) and side faces of the housing body 3.
Is preferably provided.

The blood reservoir 1 removes foreign matter and air bubbles contained in the blood flowing into the blood reservoir 25.
Two filter defoamers 7a and 7b are provided. Hereinafter, the configurations of these filtration and defoaming devices will be sequentially described.

The filtering and defoaming device 7a is a device in which vented blood from the blood inlet 5a and aspirated blood from the blood inlet 5b flow into the inside thereof, and constitutes a cardiotomy filter. As shown in FIG. 2, the filtration and defoaming device 7a includes a blood introduction tube 20 connected to the blood inlet 5a.
A blood introduction tube 14 connected to the blood inlet 5b, a filter member 15, an antifoaming member 16 installed in an upper portion inside the filter member 15, and a blood distribution member 17
And a partition 19.

The blood introduction tube 14 is a tubular member that extends substantially vertically and has an inner diameter that gradually decreases downward.
The upper end communicates with the blood inlet 5b. Also,
The lower end of the blood introduction tube 14 is located slightly above the lower end surface 161 of the defoaming member 16 described later, whereby the blood (aspirated blood) introduced into the blood introduction tube 14 from the blood inlet 5b is The blood is dropped from the lower end of the blood introduction tube 14 and supplied to the filtering and defoaming device 7a without contacting the defoaming member 16. In addition, since the lower end of the blood introduction tube 14 is located relatively above (above the lower end of the blood introduction tube 20), the foreign matter filtered by the filter member 27 causes the filtration in the defoaming device 7a. Even when the liquid level rises to some extent, it does not sink into the liquid, so that bubbling is suppressed.

The upper end of the blood introduction tube 20 is connected to the blood inlet 5
a. The lower end of the blood introduction tube 20 is preferably formed to extend below the lower end of the blood introduction tube 14. Thereby, since the blood dropped from the lower end of the blood introduction tube 20 gently collides with the blood distribution member 17, foaming can be reduced.

The constituent materials of the blood introduction tubes 14 and 20 include, for example, polycarbonate, acrylic resin, polyethylene terephthalate (PET), polybutylene terephthalate (PBT), polyethylene, polypropylene,
Polymer materials such as polystyrene, polyvinyl chloride, acrylic-styrene copolymer, acrylic-butadiene-styrene copolymer, various ceramics such as various glasses, alumina and silica, metals such as stainless steel, aluminum, copper and titanium, various Examples of the material include a carbon material and the like or a combination of two or more of them. Among them, polyvinyl chloride, polycarbonate, polystyrene, PET, and stainless steel are particularly preferable.

Around the blood introduction tubes 14 and 20, a filter member 15 preferably having a cylindrical shape is provided. The filter member 15 has a function of removing foreign substances and bubbles in blood.

The material of the filter member 15 is made of a porous material having sufficient blood permeability. Examples of such a porous material include a mesh (net) -like material, a woven fabric, a nonwoven fabric, and the like, and these can be used alone or in any combination (especially, by laminating). In the present invention, the filter member 15 preferably includes a nonwoven fabric. This is because the nonwoven fabric has excellent blood permeability and can effectively remove foreign substances in blood.

The constituent material of the filter member 15, especially the constituent material of the non-woven fabric, is a polymer such as polyester such as PET and PBT, nylon (polyamide), polyolefin such as tetron, rayon, polypropylene and polyethylene, and polyvinyl chloride. Materials include those obtained by combining two or more of these materials, and among them, polyester, polypropylene, and polyethylene are particularly preferable.

The filter member 15 may be subjected to a hydrophilic treatment such as a plasma treatment or a coating of a hydrophilic polymer material, if necessary, in order to further improve the blood permeability. In this case, the hydrophilic treatment such as the plasma treatment may be performed according to a conventional method.

As shown in FIG. 3, the filter member 15 is composed of an inner layer 155 formed by pleating the above-mentioned material and an outer layer 156 adhered to the outer periphery of the inner layer 155. ing.

Since the inner layer 155 is formed in a pleated shape, the effective area of the filter member 15 can be sufficiently secured. Further, the outer layer 156 has a function of regulating the deformation of the inner layer 155 with the defoaming member 16 and holding the filter member 15 in a fixed shape, and a relatively hard mesh, net or frame member is used. It is preferably used.

At the lower end opening of the filter member 15, the blood distribution member 1 protruding toward the inside of the filtration and defoaming device 7a is provided.
7 is mounted. The blood distribution member 17 has a function of distributing blood that has fallen from the lower end of the blood introduction tube 14 toward the inner surface of the filter member 15.

The lower end of the filter member 15 is fixed to the outer periphery of the blood distribution member 17 with a filler 18, and the upper ends of the filter member 15 and the defoaming member 16 are filled with a blood introduction tube by the filler 18. 14 is fixed to the base.

It is preferable that an antifoaming member 16 carrying an antifoaming agent is provided on the upper inner peripheral surface of the filter member 15. Thereby, the bubbles can be more reliably removed. The defoaming agent carried on the defoaming member 16 has a function of breaking bubbles when air bubbles come in contact with the defoaming agent,
Typical examples thereof include silicone (compound type, oil type, etc. containing silica).

The method of supporting the defoaming agent on the defoaming member 16 is, for example, impregnating, applying or spraying a material containing a defoaming agent, followed by drying (for example, 30 ° C., 18 ° C.).
0 minutes).

Examples of the material of the defoaming member 16 include foams such as foamed polyurethane, foamed polyethylene, foamed polypropylene, and foamed polystyrene, meshes, woven fabrics, nonwoven fabrics, and sintered bodies such as porous ceramics and resins. Although various porous materials can be mentioned, it is preferable to use a material having relatively low blood passage resistance (pressure loss).

When a foam having a low resistance to the passage of blood, such as a foamed polyurethane or other porous material, is used, the pore diameter is about 20 μm to 5 mm, and especially about 3 μm.
The thickness is preferably about 0 μm to 2 mm.

It is preferable that the position of the lower end surface 161 of the defoaming member 16 is near or above the liquid level (maximum liquid level L _max ) at the maximum blood storage volume of the blood reservoir 1.

Here, the maximum blood storage volume means a limit blood volume beyond which the blood may overflow from the blood storage tank 1 and differs depending on the function and structure of the blood storage tank 1, but is usually 70-100 of the real volume of the blood storage space 25
%.

Incidentally, the same defoaming agent as described above may also be carried on the filter member 15 (especially on the upper side) by the same carrying method.

The filter member 15 has a partition wall 19 inside.
Are installed along the axial direction (vertical direction). Thereby, the internal space of the filter member 15 is divided into a first filter chamber 71 on the right side in FIG. 2 and a second filter chamber 72 on the left side in FIG. That is, the filter chamber 71 is defined (enclosed) by the right part of the filter member 15 in FIG. 2 and the partition wall 19, and the filter chamber 72 is formed by the left part of the filter member 15 in FIG. It is defined (enclosed and formed) by the partition wall 19.

The blood introduction tube 20 is located in the first filter chamber 71, and vented blood flows from the blood inlet 5a. Further, the blood introduction tube 14 is located in the second filter chamber 72, and the aspirated blood from the blood inlet 5b flows in. That is, the vented blood and the aspirated blood flowing into the filtering and defoaming device 7a do not come into contact with each other until they pass through the filter member 15.

With such a configuration, the filtration and defoaming device 7a
The vented blood that has flowed into the filter member 1
It passes through the filter member 15 without contacting foreign substances such as fat globules, tissue fragments, denatured proteins, and aggregates other than blood filtered out by the filter 5. For this reason, the vent blood does not activate in response to the foreign matter, and a state with little damage is maintained. Therefore, damage to the whole blood that is sent (returned) after being temporarily stored in the blood storage tank 1 is reduced, and adverse effects on the living body can be reduced.

Next, the filtering and defoaming device 7b will be described. Regarding the filtering and defoaming device 7b, the description of the same items as those of the filtering and defoaming device 7a is omitted.

As shown in FIG. 4, the filtering and defoaming device 7b
The apparatus includes a blood introduction tube 8 connected to the blood inlet 5a, a filter member 9, and a defoaming member 10 installed above the filter member 9. In addition, the filtration and defoaming device 7b
Inside, a third filter chamber 73 is defined by the filter member 9, and the third filter chamber 73 communicates with the blood inlet 5 a via the blood introduction tube 8. Such a filtering and defoaming device 7b removes air bubbles and foreign substances contained in blood removed from the vena cava.

The blood introduction tube 8 is a straight tubular member extending substantially vertically, and has an upper end connected to the blood inlet 5a. Further, the lower end of the blood introduction tube 8 is extended to near the bottom in the filtration and defoaming device 7b. Thereby, the blood introduced from the blood inlet 5a into the blood introduction tube 8 is supplied into the filtration and defoaming device 7b without contacting the defoaming member 10 described later, and is introduced into the blood at the time of such blood introduction. Is prevented from being mixed with the antifoaming agent.

A priming liquid introduction pipe 11 smaller in diameter than the blood introduction pipe 8 is provided in the filtration / defoaming apparatus 7b.
The upper end is connected to the priming liquid inlet 5d. Further, the lower end of the priming liquid introduction pipe 11 is extended to near the bottom in the filtration and defoaming device 7b, similarly to the blood introduction pipe 8.

Around the blood introduction pipe 8 and the priming liquid introduction pipe 11, a filter member 9 and a defoaming member 10 are provided.

As the material of the filter member 9, the same material as described above is preferably used, but it is particularly preferable to include a mesh-like material. This is because the mesh is excellent in blood permeability, has high opening accuracy, and can effectively remove bubbles and the like.

Here, the mesh is a sheet-like member having a regularly arranged mesh.
Examples include fiber woven or knitted articles, integrally molded articles, and processed articles.

The constituent material of the filter member 9, particularly, the constituent material of the mesh is a polymer such as polyester such as PET and PBT, nylon (polyamide), polyolefin such as tetron, rayon, polypropylene and polyethylene, and polyvinyl chloride. Material, aluminum,
Metal materials such as stainless steel, or a combination of two or more of these materials may be mentioned.
In particular, polyester, polypropylene, polyethylene,
Stainless steel is preferred.

The opening of the mesh of the mesh used for the filter member 9 is preferably about 15 to 300 μm, particularly preferably 20 to 200 μm. If it exceeds 300 μm, fine air bubbles may pass through the mesh network together with blood, and if it is less than 15 μm, the blood passage resistance increases, and the liquid level of the blood in the filtration and defoaming device 7b increases. This is because it tends to rise.

The filter member 9 can be subjected to a hydrophilic treatment such as a plasma treatment or a coating of a hydrophilic polymer material, if necessary, in order to further improve the blood permeability. In this case, the hydrophilic treatment such as the plasma treatment may be performed according to a conventional method.

With the filter member 9 described above, for example, bubbles having a diameter of about 20 μm or more can be effectively removed.

Since such a filter member 9 itself has low rigidity, in the configuration example shown in FIG. 4, it is supported and fixed by a lattice-shaped frame member 12. As the constituent material of the frame member 12, the same material as that of the blood introduction tube 8 can be used.

It is preferable that an antifoaming member 10 carrying the same antifoaming agent as described above is provided above the filter member 9. The material of the defoaming member 10 is the same as described above. In addition, the filter member 9 (particularly the upper side)
Also, the same defoaming agent as described above may be supported by the same supporting method.

It is preferable that the position 101 of the lower end face of the defoaming member 10 is near or above the liquid level (maximum liquid level L _max ) at the maximum blood storage volume of the blood reservoir 1.

In the present invention, the filter defoaming device 7b may not be provided.

<Second Embodiment> FIG. 6 is a partial sectional side view showing a second embodiment of the blood reservoir according to the present invention.

Hereinafter, a second embodiment of the blood reservoir according to the present invention will be described with reference to this figure, but the description will focus on the differences from the above-described embodiment, and a description of similar items will be omitted.

The blood reservoir 1 'shown in FIG. 6 is replaced with a filter defoamer 7a for filtering and removing vent blood and a filter defoamer for filtering and removing aspirated blood, instead of the filter defoamer 7a of the blood reservoir 1. It is the same as the first embodiment except that it has a device 7d. That is, the present embodiment is different from the first embodiment in that the filtering and defoaming device for vented blood and the filtering and defoaming device for aspirated blood are separate.

The filtering and defoaming device 7c for vented blood includes a blood introduction tube 21 having an upper end communicating with the blood inflow port 5a, a filter member 22 provided around the blood introduction tube 21,
It has a defoaming member 23 installed at an upper part inside the filter member 22 and a blood distribution member 24 installed at the lower end of the filter member 22. Inside the first filter chamber, a filter member 22 is provided. Is formed around the periphery.

Further, a filtration and defoaming device 7d for aspirated blood is provided.
Is a blood introduction tube 26 whose upper end communicates with the blood inlet 5b.
A filter member 27 installed around the blood introduction tube 26, a defoaming member 28 installed at an upper part inside the filter member 27, and a blood distribution member 29 installed at the lower end of the filter member 27. are doing.

In these filtration and defoaming devices 7c and 7d, filter members 22 and 27, defoaming members 23 and 28,
The details of the blood distribution members 24 and 29
This is the same as that described for the filtering and defoaming device 7a of the embodiment.

Further, a blood introducing tube 21 for introducing vent blood is provided.
Is preferably provided to extend below the blood introduction tube 26 for introducing aspirated blood. Thus, foaming can be reduced as in the first embodiment.

In the present embodiment, the filtering and defoaming device 7c
The vented blood that has flowed into the filter member does not come into contact with foreign substances such as fat globules, tissue fragments, denatured proteins, and aggregates other than blood that has been filtered from the aspirated blood by the filter member 27 in the filtration and defoaming device 7d. Pass 23. Therefore, the vent blood does not react with the foreign substance and is not activated. Therefore, similarly to the first embodiment, the damage of the blood which is temporarily stored in the blood storage tank 1 'and then sent (returned) is reduced as a whole, and the adverse effect on the living body can be reduced.

The above-mentioned effect is more remarkable by setting the filter member 23 defining the first filter chamber 71 and the filter member 27 defining the second filter chamber 72 under different conditions. It is exhibited in. Here, the condition of the filter member refers to various conditions such as an effective area, a material, a shape, a structure, a dimension, and an opening (opening).

For example, since the aspirated blood usually has a larger inflow than the vented blood, the filter member 27 for the aspirated blood is generally used.
Has a larger effective area than the filter member 23 for vented blood, foreign substances and bubbles contained in the aspirated blood can be removed more effectively.

In addition, the filter member 23 and the filter member 27 may be made of different materials or apertures in consideration of the difference in the amount of foreign matter as described above.

Further, by making the total carrying amount (total weight) of the defoaming agent of the defoaming member 23 with respect to the vent blood smaller than the total carrying amount of the defoaming agent of the defoaming member 28 with respect to the aspirated blood.
The amount of the antifoaming agent mixed into the blood is reduced, and the blood damage can be further reduced. That is, since the amount of air bubbles contained in the vent blood is usually smaller than that of the aspirated blood, it is possible to reduce the amount of the antifoaming agent. With this, the amount of the antifoaming agent mixed into the blood can be reduced as a whole, and an excellent defoaming effect can be stably obtained.

In order to provide a difference in the total amount of the defoaming agent carried between the two defoaming members 23 and 28, the volume of the defoaming member is not limited even if the amount (weight per unit volume) of the defoaming agent is different. They may be different, or both may be different.

The defoaming agents in the defoaming member 23 and the defoaming member 28 may have the same composition or different compositions (for example, different types and amounts of additives).

As described above, in this embodiment, since the filtration and defoaming device for vented blood and the filtration and defoaming device for aspirated blood are separated, various conditions of the filtration and defoaming device are set for each blood. Can be easily optimized, thereby improving the condition of the blood flowing out of the blood reservoir 1 '.

Further, in the first embodiment, the first
By providing the above-described differences between the filter chamber 71 and the second filter chamber 72 in the conditions of the filter member 15 and the carrying amount of the defoaming agent, the same effects as in the present embodiment can be obtained.

Although the blood reservoir of the present invention has been described with reference to the illustrated embodiment, the present invention is not limited to this, and each part constituting the blood reservoir may have any function that can exhibit the same function. It can be replaced with that of the configuration.

[0093]

Next, the blood reservoir of the present invention will be described in more detail with reference to specific examples.

(Example) A blood reservoir having the structure shown in FIG. 6 was manufactured. Various conditions in this blood reservoir are as shown in Table 1 below.

[0095]

[Table 1]

Comparative Example A blood reservoir having a different structure from the blood reservoir shown in FIGS. 1 to 4 in that the blood reservoir was not provided with the partition wall 19 and the blood introduction tube 20 was prepared. That is, in the blood reservoir of this comparative example, the blood flowing from the blood inlet 5a and the blood flowing from the blood inlet 5b are different from each other in the filter member 1.
Merge before passing through 5. Various conditions in this blood reservoir are as shown in Table 2 below. In the blood reservoir of the comparative example, the same reference numerals as in FIGS. 1 to 4 are used for the respective parts for convenience.

[0097]

[Table 2]

The following experiments were performed on the blood reservoirs of the above-mentioned Example and Comparative Example. FIG. 7 is a blood circulation circuit diagram in this experiment.

Each blood reservoir of the example and the comparative example was connected to the circulation circuit shown in FIG. That is, in this circulation circuit, the roller pump 60 and the heat exchanger 61 were provided in the line connected to the blood outlet 6. When this line exits the heat exchanger 61, it is branched into two lines, a vent line 62 and a suction line 63, the tube of the vent line 62 is connected to the blood inlet 5a, and the tube of the suction line 63 is connected to the blood line. It was connected to the inlet 5b. Further, an air mixing line 64 was provided in the middle of the suction line 63.

Such a circulation circuit was filled with a mixture of 200 ml of heparinized human fresh blood and 350 ml of lactated Ringer's solution, at a blood temperature of 37 ° C. and an average flow rate of 1000 ml / min.
For perfusion (circulation). At this time, air (bubbles) is added to the blood flowing through the suction line 63 at a rate of 10 ml / min.
Was mixed. After a while, the second filter chamber 7
In No. 2, it was observed that aggregates were separated from the blood in the suction line 63 by filtration.

Two hours after the start of the perfusion, blood immediately after the blood outlet 6 was collected from each circulation circuit, and the platelet count, white blood cell count, β-TG, and granulocyte elastase were added to each blood sample. It was measured. Note that β-TG is a factor generated by activating platelets, and granulocyte elastase is a factor generated by activating leukocytes.

The results of the measurement are shown in Table 3 below. The number of platelets and the number of leukocytes are shown as percentages (% of pre) with respect to the measured value before perfusion.

[0103]

[Table 3]

From the results shown in Table 3, it can be seen that the number of platelets and the number of leukocytes after blood circulation in the circulation circuit using the blood storage tank of the example are much larger than those in the circulation circuit using the blood storage tank of the comparative example. I was Further, in the circulation circuit using the blood reservoir of the example, β-TG and granulocyte elastase were significantly less than in the circulation circuit using the blood reservoir of the comparative example, and the degree of blood activation was small. From the above, it has been clarified that the circulation circuit using the blood reservoir of the example has significantly reduced blood damage as compared with the circulation circuit using the blood reservoir of the comparative example.

[0105]

As described above, according to the present invention, since the activation of the inflowing vent blood can be suppressed, the damage to the stored blood can be reduced.

When the filter member defining the first filter chamber and the filter member defining the second filter chamber have different conditions from each other, each of the vented blood and the aspirated blood is different. , And the above-mentioned effect is more remarkably exhibited.

In the case where the defoaming means is provided, if a difference is provided between the total amount of the defoaming agent carried in the first filter chamber and the total amount of the defoaming agent carried in the second filter chamber, the difference between the storage amount This can further reduce the damage to the blood.

[Brief description of the drawings]

FIG. 1 is a side view showing a first embodiment of a blood reservoir according to the present invention.

FIG. 2 is a sectional view taken along line AA in FIG.

FIG. 3 is a sectional view taken along line CC in FIG. 2;

FIG. 4 is a sectional view taken along line BB in FIG.

FIG. 5 is a circuit diagram in extracorporeal blood circulation in an artificial lung.

FIG. 6 is a partial sectional side view showing a second embodiment of the blood reservoir according to the present invention.

FIG. 7 is a diagram showing a blood circulation circuit used in an experiment in an example.

[Explanation of symbols]

1, 1 'blood storage tank 2 housing 25 blood storage space 3 housing body 31 projecting part 4 lid 5a, 5b, 5c blood inlet 5d priming liquid inlet 5e deaeration port 6 blood outlet 7a, 7b, 7c, 7d Foam device 71 First filter chamber 72 Second filter chamber 73 Third filter chamber 8 Blood introduction tube 9 Filter member 10 Defoaming member 101 Position 11 Priming liquid introduction tube 12 Frame member 14 Blood introduction tube 15 Filter member 155 Inner layer 156 Outer layer 16 Defoaming member 161 Lower end surface 17 Blood distribution member 18 Filler 19 Partition wall 20, 21 Blood introduction tube 22 Filter member 23 Defoaming member 24 Blood distribution member 26 Blood introduction tube 27 Filter member 28 Defoaming member 29 Blood distribution member 60 roller pump 61 heat exchanger 62 vent line 3 the suction line 64 aerated line 80 vent the suction line 81 heart chamber (thoracic) in the suction line 82, 83 pump 84 blood removal line 85 blood feed pump 86 oxygenator 87 arterial filter 88 blood feed line L _max maximum liquid level

Claims (11)

[Claims] 1. A housing having a first inlet into which vented blood from inside the heart flows, a second inlet into which aspirated blood from outside the heart flows, and a blood outlet, wherein the housing has: And a filter member for filtering the inflowing blood, wherein the vented blood flowing into the housing is configured to pass through the filter member without contacting foreign matter filtered out from the aspirated blood. A blood reservoir characterized by the following. 2. A first filter chamber communicating with the first inlet, at least a part of which communicates with a first filter chamber defined by the filter member, and the second inlet, and at least a part thereof. The blood reservoir according to claim 1, further comprising a second filter chamber defined by the filter member. 3. The blood reservoir according to claim 2, wherein the first filter chamber and the second filter chamber are formed by partitioning a space surrounded by the same filter member by a partition. 4. The blood reservoir according to claim 2, wherein the first filter chamber and the second filter chamber are defined by separate filter members. 5. The blood reservoir according to claim 4, wherein the filter member defining the first filter chamber and the filter member defining the second filter chamber have different conditions. 6. The effective area of a filter member defining the first filter chamber and an effective area of a filter member defining the second filter chamber are different from each other. Blood reservoir. 7. The blood reservoir according to claim 1, further comprising defoaming means in which an antifoaming agent is carried on the filter member and / or the carrier. 8. A filter member defining the first filter chamber and / or an antifoaming agent carried on a carrier installed in the first filter chamber, and defining the second filter chamber. The blood reservoir according to claim 7, further comprising a filter member and / or an antifoaming agent carried on a carrier provided in the second filter chamber, wherein the total carrying amounts of both are different from each other. 9. A first blood introduction tube for introducing blood from the first inflow port to the first filter chamber;
The blood reservoir according to any one of claims 2 to 8, further comprising a second blood introduction tube for introducing blood from the inflow port into the second filter chamber. 10. The first blood introduction tube is provided extending below the second blood introduction tube.
The blood reservoir according to 1. 11. The housing has a third inflow port into which blood from the vena cava flows, and communicates with the third inflow port, at least a portion of which is defined by the filter member. The blood reservoir according to any one of claims 2 to 10, further comprising a third filter chamber.