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Application filed by استرا اكتيبولاغيت, الوف براندستروم ارنيfiledCriticalاسترا اكتيبولاغيت
Priority to JO19911707ApriorityCriticalpatent/JO1707B1/en
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The present invention relates to an improved method for the synthesis of omeprazole, comprising the steps of reacting 5- methoxy -2- [(4-methoxy -3.5-dimethyl -2- pyridinyl) methylthio] 1H benzimidazole with m-chloroperoxybenzoic acid in a methylene chloride solution at a substantially constant Ph of about 8.0 to 8.6 extracting the reaction mixture with aqueous naOH, separating the aqueous phase from the organic phase, and adding an alkyl format to the aqueous phase, resulting in crystallization of omeprazole.
JO19911707A1991-07-021991-07-02Improved method for synthesis
JO1707B1
(en)