IT1227626B - Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione - Google Patents

Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione

Info

Publication number
IT1227626B
IT1227626B IT8822770A IT2277088A IT1227626B IT 1227626 B IT1227626 B IT 1227626B IT 8822770 A IT8822770 A IT 8822770A IT 2277088 A IT2277088 A IT 2277088A IT 1227626 B IT1227626 B IT 1227626B
Authority
IT
Italy
Prior art keywords
increased dissolution
drugs
procedure
preparation
increased
Prior art date
Application number
IT8822770A
Other languages
English (en)
Other versions
IT8822770A0 (it
Inventor
Mara Lucia Lovrecich
Original Assignee
Vectorpharma Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vectorpharma Int filed Critical Vectorpharma Int
Publication of IT8822770A0 publication Critical patent/IT8822770A0/it
Priority to IT8822770A priority Critical patent/IT1227626B/it
Priority to YU02211/89A priority patent/YU221189A/xx
Priority to IL9245489A priority patent/IL92454A/en
Priority to DK198905958A priority patent/DK175684B1/da
Priority to DE68923157T priority patent/DE68923157T2/de
Priority to HU896191A priority patent/HU203468B/hu
Priority to SU894742518A priority patent/RU1837868C/ru
Priority to EP89121865A priority patent/EP0371431B1/en
Priority to AT89121865T priority patent/ATE123940T1/de
Priority to KR1019890017219A priority patent/KR900007398A/ko
Priority to PT92416A priority patent/PT92416B/pt
Priority to ES89121865T priority patent/ES2076192T3/es
Priority to JP1308833A priority patent/JP2823170B2/ja
Priority to CA002004064A priority patent/CA2004064C/en
Priority to FI895693A priority patent/FI895693A0/fi
Application granted granted Critical
Publication of IT1227626B publication Critical patent/IT1227626B/it
Priority to US07/827,496 priority patent/US5354560A/en
Priority to SU925052176A priority patent/RU2097027C1/ru
Priority to US08/203,034 priority patent/US5449521A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/797—Lipid particle
    • Y10S977/798—Lipid particle having internalized material
    • Y10S977/799—Containing biological material
    • Y10S977/801—Drug
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Electroluminescent Light Sources (AREA)
  • Control Of El Displays (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT8822770A 1988-11-28 1988-11-28 Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione IT1227626B (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT8822770A IT1227626B (it) 1988-11-28 1988-11-28 Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione
YU02211/89A YU221189A (en) 1988-11-28 1989-11-22 Process for obtaining pharmaceutic compounds, with increased dissolving speed
AT89121865T ATE123940T1 (de) 1988-11-28 1989-11-27 Arzneimittel auf trägern mit erhöhter lösungsgeschwindigkeit und verfahren zu ihrer herstellung.
ES89121865T ES2076192T3 (es) 1988-11-28 1989-11-27 Farmacos soportados con proporcion de disolucion incrementada, y un proceso para su preparacion.
DE68923157T DE68923157T2 (de) 1988-11-28 1989-11-27 Arzneimittel auf Trägern mit erhöhter Lösungsgeschwindigkeit und Verfahren zu ihrer Herstellung.
HU896191A HU203468B (en) 1988-11-28 1989-11-27 Process for producing pharmaceutical compositions on carrier with improved solubility
SU894742518A RU1837868C (ru) 1988-11-28 1989-11-27 Способ получени лекарственного средства на носителе с повышенной скоростью растворени
EP89121865A EP0371431B1 (en) 1988-11-28 1989-11-27 Supported drugs with increased dissolution rate, and a process for their preparation
IL9245489A IL92454A (en) 1988-11-28 1989-11-27 Drugs with an increased rate of mass and preparation
KR1019890017219A KR900007398A (ko) 1988-11-28 1989-11-27 증가된 용해속도를 갖는 지지된 약물 및 이의 제조방법
PT92416A PT92416B (pt) 1988-11-28 1989-11-27 Processo de preparacao de drogas suportadas possuindo velocidade de dissolucao aumentada
DK198905958A DK175684B1 (da) 1988-11-28 1989-11-27 Lægemiddel med forøget opløsningshastighed og indeholdende et bærestof samt fremgangsmåde til fremstilling af et sådant lægemiddel
JP1308833A JP2823170B2 (ja) 1988-11-28 1989-11-28 溶解率を向上した担体支持薬剤およびその製造方法
CA002004064A CA2004064C (en) 1988-11-28 1989-11-28 Supported drugs with increased dissolution rate, and a process for theirpreparation
FI895693A FI895693A0 (fi) 1988-11-28 1989-11-28 Baerare/laekemedelskompositioner med foerbaettrad loeslighet och foerfarande foer framstaellning av dessa.
US07/827,496 US5354560A (en) 1988-11-28 1992-01-30 Supported drugs with increased dissolution rate, and a process for their preparation
SU925052176A RU2097027C1 (ru) 1988-11-28 1992-07-16 Лекарственные препараты на носителе
US08/203,034 US5449521A (en) 1988-11-28 1994-02-28 Supported drugs with increased dissolution rate, and a process for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8822770A IT1227626B (it) 1988-11-28 1988-11-28 Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione

Publications (2)

Publication Number Publication Date
IT8822770A0 IT8822770A0 (it) 1988-11-28
IT1227626B true IT1227626B (it) 1991-04-23

Family

ID=11200272

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8822770A IT1227626B (it) 1988-11-28 1988-11-28 Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione

Country Status (16)

Country Link
US (2) US5354560A (it)
EP (1) EP0371431B1 (it)
JP (1) JP2823170B2 (it)
KR (1) KR900007398A (it)
AT (1) ATE123940T1 (it)
CA (1) CA2004064C (it)
DE (1) DE68923157T2 (it)
DK (1) DK175684B1 (it)
ES (1) ES2076192T3 (it)
FI (1) FI895693A0 (it)
HU (1) HU203468B (it)
IL (1) IL92454A (it)
IT (1) IT1227626B (it)
PT (1) PT92416B (it)
RU (2) RU1837868C (it)
YU (1) YU221189A (it)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5569469A (en) * 1984-10-16 1996-10-29 Vectorpharma International, S.P.A. Poorly soluble medicaments supported on polymer substances in a form suitable for increasing their dissolving rate
IT1241088B (it) * 1990-03-27 1993-12-29 Chiesi Farma Spa Procedimento per la preparazione di complessi piroxicam/ciclodestrina,prodotti ottenuti e loro composizioni farmaceutiche
HU210921B (en) * 1990-03-28 1995-09-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine formed with cyclodextrines and pharmaceutical compositions containing them
IT1246188B (it) * 1990-07-27 1994-11-16 Resa Farma Procedimento per la preparazione di composizioni farmaceutiche aventi aumentata velocita' di dissoluzione della sostanza attiva e composizioni ottenute.
IT1243745B (it) * 1990-10-17 1994-06-21 Vectorpharma Int Composizioni terapeutiche transdermali contenenti farmaco e/o agente promotore dell'assorbimento cutaneo supportato su particelle microporose e microsfere polimeriche e loro preparazione.
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
US5552160A (en) * 1991-01-25 1996-09-03 Nanosystems L.L.C. Surface modified NSAID nanoparticles
ATE196426T1 (de) * 1991-06-21 2000-10-15 Takeda Chemical Industries Ltd Zyklodextrin-zusammensetzung enthaltend fumagillol-derivate
DK0644755T3 (da) * 1992-06-10 1997-09-22 Nanosystems Llc Overflademodificerede NSAID-nanopartikler
IT1255462B (it) * 1992-07-28 1995-11-02 Grazia Maffione Metodo di preparazione di composti di inclusione di nimesulide con ciclodestrine
AU660852B2 (en) * 1992-11-25 1995-07-06 Elan Pharma International Limited Method of grinding pharmaceutical substances
HU213200B (en) 1993-05-12 1997-03-28 Chinoin Gyogyszer Es Vegyeszet The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production
GB9316580D0 (en) * 1993-08-10 1993-09-29 Smithkline Beecham Plc Pharmaceutical composition
TW384224B (en) * 1994-05-25 2000-03-11 Nano Sys Llc Method of preparing submicron particles of a therapeutic or diagnostic agent
US5684121A (en) * 1994-12-06 1997-11-04 Isp Investments Inc. N-vinyl lactam polymer containing tablets of low friability and high rate of dissolution
US5547948A (en) * 1995-01-17 1996-08-20 American Home Products Corporation Controlled release of steroids from sugar coatings
US5759577A (en) * 1995-01-17 1998-06-02 American Home Products Corporation Controlled release of steroids from sugar coatings
US5518738A (en) * 1995-02-09 1996-05-21 Nanosystem L.L.C. Nanoparticulate nsaid compositions
US5612053A (en) 1995-04-07 1997-03-18 Edward Mendell Co., Inc. Controlled release insufflation carrier for medicaments
US6348469B1 (en) 1995-04-14 2002-02-19 Pharma Pass Llc Solid compositions containing glipizide and polyethylene oxide
ES2149471T3 (es) * 1995-04-20 2000-11-01 Eurand Int Compuesto con glicolato de almidon sodico como material soporte y productos a base de dicho compuesto.
US20050267302A1 (en) * 1995-12-11 2005-12-01 G.D. Searle & Co. Eplerenone crystalline form exhibiting enhanced dissolution rate
US5686133A (en) * 1996-01-31 1997-11-11 Port Systems, L.L.C. Water soluble pharmaceutical coating and method for producing coated pharmaceuticals
HUP9600758A2 (en) * 1996-03-27 1998-03-02 Cyclolab Ciklodextrin Kutato F Diclofenac composition of diminished gastrointestinal irritation and enhanced biological resorption
US6048547A (en) * 1996-04-15 2000-04-11 Seth; Pawan Process for manufacturing solid compositions containing polyethylene oxide and an active ingredient
WO1997039761A1 (en) 1996-04-19 1997-10-30 Alpha Therapeutic Corporation A process for viral inactivation of lyophilized blood proteins
FR2757397B1 (fr) * 1996-12-23 1999-03-05 Mazal Pharma Composition pharmaceutique a base de rheine ou de diacerheine a biodisponibilite amelioree
US20050004049A1 (en) * 1997-03-11 2005-01-06 Elan Pharma International Limited Novel griseofulvin compositions
US6797289B2 (en) * 1998-02-13 2004-09-28 Nutramax Laboratories, Inc. Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals
US20070141181A1 (en) 1998-02-13 2007-06-21 Nutramax Laboratories, Inc. Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals
US6451771B1 (en) 1999-02-12 2002-09-17 Nutramax Laboratories, Inc. Use of anabolic agents anti-catabolic agents and antioxidant agents for protection treatment and repair of connective tissues in humans and animals
US6086242A (en) * 1998-02-27 2000-07-11 University Of Utah Dual drive planetary mill
US6197347B1 (en) 1998-06-29 2001-03-06 Andrx Pharmaceuticals, Inc. Oral dosage for the controlled release of analgesic
US6524620B2 (en) 1998-07-20 2003-02-25 Andrx Pharmaceuticals, Inc. Diltiazem controlled release formulation and method of manufacture
FR2786100B1 (fr) * 1998-11-24 2002-03-01 Aventis Laboratoire Nouvelle application therapeutique de la nicergoline
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6264981B1 (en) 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
US20030083493A1 (en) * 1999-12-08 2003-05-01 Barton Kathleen P. Eplerenone drug substance having high phase purity
AU784490B2 (en) * 1999-12-08 2006-04-13 Pharmacia Corporation Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect
EA008449B1 (ru) * 1999-12-08 2007-06-29 Фармация Корпорейшн Кристаллическая форма эплеренона
UA74539C2 (en) 1999-12-08 2006-01-16 Pharmacia Corp Crystalline polymorphous forms of celecoxib (variants), a method for the preparation thereof (variants), a pharmaceutical composition (variants)
US20060153914A1 (en) * 1999-12-10 2006-07-13 Biovail Laboratories International S.R.L. Chronotherapeutic diltiazem formulations and the administration thereof
US7108866B1 (en) 1999-12-10 2006-09-19 Biovall Laboratories International Srl Chronotherapeutic diltiazem formulations and the administration thereof
MY120279A (en) * 2000-05-26 2005-09-30 Pharmacia Corp Use of a celecoxib composition for fast pain relief
US20020146409A1 (en) * 2001-01-30 2002-10-10 Herring Steven W. Methods for stabilizing lyophilized blood proteins
ES2375105T3 (es) 2001-06-18 2012-02-24 Noven Pharmaceuticals, Inc. Administración mejorada de medicamentos en los sistemas transdérmicos.
EP1269994A3 (en) * 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
EP1404302B1 (en) * 2001-06-22 2010-11-03 Pfizer Products Inc. Pharmaceutical compositions comprising adsorbates of amorphous drug
US20030073609A1 (en) 2001-06-29 2003-04-17 Pinkerton Thomas C. Enhanced pharmacokinetic profile of intradermally delivered substances
ES2295379T3 (es) * 2001-06-29 2008-04-16 Eurand Pharmaceuticals Ltd. Procedimiento de activacion termodinamica de medicamentos insolubles en agua cargados en polimeros reticulados.
MXPA04002762A (es) * 2001-09-25 2004-06-29 Pharmacia Corp Formas de estado solido de n-(2 -hidroxiacetil) -5-(4-piperidil) -4-(4-pirimidinil) -3-(4-clorofenil) pirazol.
CA2474838C (en) * 2002-02-01 2009-01-06 Pfizer Products Inc. Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials
US20040105889A1 (en) * 2002-12-03 2004-06-03 Elan Pharma International Limited Low viscosity liquid dosage forms
US9101540B2 (en) * 2002-04-12 2015-08-11 Alkermes Pharma Ireland Limited Nanoparticulate megestrol formulations
US7101576B2 (en) 2002-04-12 2006-09-05 Elan Pharma International Limited Nanoparticulate megestrol formulations
US20100226989A1 (en) * 2002-04-12 2010-09-09 Elan Pharma International, Limited Nanoparticulate megestrol formulations
AU2003230885A1 (en) * 2002-04-12 2003-10-27 Elan Pharma International Ltd. Nanoparticulate megestrol formulations
ITMI20021074A1 (it) * 2002-05-20 2003-11-20 Actimex S R L Composizione ternaria comprendente una sostanza attiva e processo di comacinazione per la sua preparazione
UY27939A1 (es) 2002-08-21 2004-03-31 Glaxo Group Ltd Compuestos
DE10259640A1 (de) * 2002-12-18 2004-07-08 Hager & Werken Gmbh & Co Kg Einfärbemittel zur Sichtbarmachung von Plaque-Bildung auf Zähnen sowie Verfahren zur Herstellung eines solchen Einfärbemittels
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
US9358296B2 (en) 2003-02-24 2016-06-07 Pharmaceutical Productions Inc. Transmucosal drug delivery system
US9498454B2 (en) 2003-02-24 2016-11-22 Pharmaceutical Productions Inc. Transmucosal drug delivery system
US10172810B2 (en) 2003-02-24 2019-01-08 Pharmaceutical Productions, Inc. Transmucosal ketamine delivery composition
US9254294B2 (en) 2003-02-24 2016-02-09 Pharmaceutical Productions Inc. Transmucosal hormone delivery system
CA2516816C (en) 2003-02-24 2012-02-07 Pharmaceutical Productions, Inc. Transmucosal drug delivery system
DE60309356T2 (de) * 2003-06-27 2007-08-30 Bioprogress S.P.A. Zusammensetzung, durch zusammen vermahlen eines wirkstoffes mit einem n-vinyl-2-pyrrolidon/vinylacetatkopolymers erhältlich
CN101875961B (zh) 2003-07-22 2015-01-07 艾尼纳制药公司 用于预防和治疗相关病症而作为5-ht2a血清素受体调节剂的二芳基和芳基杂芳基脲衍生物
BRPI0413277A (pt) * 2003-08-04 2006-10-10 Pfizer Prod Inc composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas
AU2006262144A1 (en) * 2005-06-22 2007-01-04 Elan Pharma International, Limited Nanoparticulate megestrol formulations
BRPI0709410A2 (pt) * 2006-03-20 2011-07-12 Javelin Pharmaceuticals Inc composição farmacêutica e método para tratar um mamìfero necessitando de um agente analgésico, anti-inflamatório ou um antipirético
JP5823093B2 (ja) 2006-03-28 2015-11-25 ジャヴェリン ファーマシューティカルズ インコーポレイテッド 低投与量のジクロフェナク及びβ−シクロデキストリンの配合物
AU2016203251B2 (en) * 2006-06-30 2017-11-16 Iceutica Pty Ltd Methods for the Preparation of Biologically Active Compounds in Nanoparticle Form
CA2653384C (en) * 2006-06-30 2017-03-14 Iceutica Pty Ltd Methods for the preparation of biologically active compounds in nanoparticulate form
CL2007002689A1 (es) 2006-09-18 2008-04-18 Vitae Pharmaceuticals Inc Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras.
TWI415845B (zh) 2006-10-03 2013-11-21 Arena Pharm Inc 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物
EP2190844B3 (en) 2007-08-15 2013-07-17 Arena Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
US8821924B2 (en) 2007-09-14 2014-09-02 Wockhardt Ltd. Rhein or diacerein compositions
US20100285114A1 (en) * 2007-09-27 2010-11-11 Rahul Dabre Pharmaceutical compositions of rhein or diacerein
EP2520285A1 (en) * 2007-09-27 2012-11-07 Wockhardt Limited Pharmaceutical compositions of rhein or diacerein
WO2009048940A2 (en) * 2007-10-08 2009-04-16 Dr. Reddy's Laboratories Ltd. Diacerein pharmaceutical formulations
US8642062B2 (en) 2007-10-31 2014-02-04 Abbott Cardiovascular Systems Inc. Implantable device having a slow dissolving polymer
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
NO2364142T3 (it) 2008-10-28 2018-06-16
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
EP2349336B1 (en) * 2008-10-28 2017-11-22 Agency For Science, Technology And Research Mesoporous material excipients for poorly aqueous soluble ingredients
US7828996B1 (en) * 2009-03-27 2010-11-09 Abbott Cardiovascular Systems Inc. Method for the manufacture of stable, nano-sized particles
DK2421513T3 (en) 2009-04-24 2018-03-26 Iceutica Pty Ltd UNKNOWN FORMULATION WITH INDOMETHACIN
US20120164203A1 (en) * 2009-06-17 2012-06-28 Raman Premachandran Process for preparation of stable, microencapsulated and sustained release biocidal actives and composition thereof
AR077692A1 (es) 2009-08-06 2011-09-14 Vitae Pharmaceuticals Inc Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo
JP5870775B2 (ja) * 2011-05-11 2016-03-01 ライオン株式会社 錠剤及びその製造方法
EP2734204A4 (en) 2011-07-22 2015-03-18 Chemocentryx Inc POLYMORPHIC FORMS OF 4-TERT-BUTYL-N- [4-CHLORO-2- (1-OXY-PYRIDINE-4-CARBONYL) -PHENYL] -BENZENE-SULFONAMIDE SODIUM SALT
CA2841967C (en) 2011-07-22 2020-06-16 Chemocentryx, Inc. A crystalline form of the sodium salt of 4-tert-butyl-n-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzenesulfonamide
KR101378951B1 (ko) * 2011-07-29 2014-03-31 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 생체이용률이 향상된 초산 메게스트롤 분말을 포함하는 경구투여용 제제 및 이의 제조방법
PL2751094T3 (pl) 2011-09-01 2018-11-30 Glaxo Group Limited Nowa postać krystaliczna
WO2013032310A1 (ko) * 2011-09-02 2013-03-07 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 메게스트롤 속붕해정 및 이의 제조 방법
EP2793856B1 (en) * 2011-12-23 2015-12-16 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Orally-disintegrating formulations of flurbiprofen
US20150004229A1 (en) * 2011-12-27 2015-01-01 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Combined pharmaceutical formulation containing diacerein
ITMI20120092A1 (it) 2012-01-26 2013-07-27 Micro Macinazione S A Compositi di inclusione farmaco-carrier preparati con processo di attivazione meccano-chimica mediante mulini a getto di fluido ad alta energia
KR102237799B1 (ko) 2012-11-14 2021-04-08 더블유.알. 그레이스 앤드 캄파니-콘. 생물학적 활성 물질 및 비-정렬된 무기 산화물을 함유하는 조성물
US9526734B2 (en) 2014-06-09 2016-12-27 Iceutica Pty Ltd. Formulation of meloxicam
PE20170146A1 (es) 2014-06-25 2017-03-08 Glaxosmithkline Ip Dev Ltd Sales cristalinas de (s)-6-((1-acetilpiperidin-4-il)amino)-n-(3-(3,4-dihidroisoquinolin-2(1h)-il)-2-hidroxipropil)pirimidino-4-carboxamida
CN107148418A (zh) 2014-09-08 2017-09-08 葛兰素史密斯克莱知识产权发展有限公司 2‑(4‑(4‑乙氧基‑6‑氧代‑1,6‑二氢吡啶‑3‑基)‑2‑氟苯基)‑n‑(5‑(1,1,1‑三氟‑2‑甲基丙‑2‑基)异噁唑‑3‑基)乙酰胺的晶型
AU2016276966A1 (en) 2015-06-12 2018-01-18 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of REM sleep behavior disorder
JP2018520187A (ja) 2015-07-15 2018-07-26 アクソヴァント サイエンシーズ ゲゼルシャフト ミット ベシュレンクテル ハフツングAxovant Sciences GmbH 神経変性疾患と関連する幻覚の予防および処置のために有用な５−ｈｔ２ａセロトニン受容体のモジュレーターとしてのジアリールおよびアリールヘテロアリール尿素誘導体

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3079303A (en) * 1958-12-11 1963-02-26 Smith Kline French Lab Basic tablet granulation and process of using same
BE590276A (it) * 1959-04-30
US3328256A (en) * 1963-05-27 1967-06-27 William E Gaunt Spherical beads and their production
NL6414091A (nl) * 1964-12-04 1966-06-06 Organon Nv Werkwijze voor het vloeibaar maken van poeders alsmede de aldus verkregen poeders
JPS5132719A (en) * 1974-09-13 1976-03-19 Yoshinobu Nakai Iyakuhinnoshorihoho
US4107288A (en) * 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US4037794A (en) * 1974-09-23 1977-07-26 Dierks & Sohne Granulation apparatus
DE2742442C3 (de) * 1977-09-21 1980-03-06 Balcke-Duerr Ag, 4030 Ratingen Elastische Kupplung
JPS5849428A (ja) * 1981-09-16 1983-03-23 Takeda Chem Ind Ltd 細粒剤の製造法
DE3485000D1 (de) * 1983-06-28 1991-10-10 Takeda Chemical Industries Ltd Gemahlene mischung.
DE3346123A1 (de) * 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
GB8403359D0 (en) * 1984-02-08 1984-03-14 Erba Farmitalia Pharmaceutical compositions
US4837031A (en) * 1987-09-17 1989-06-06 Mallinckrodt, Inc. Compositions containing ibuprofen

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HU203468B (en) 1991-08-28
DK595889D0 (da) 1989-11-27
PT92416A (pt) 1990-05-31
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DE68923157D1 (de) 1995-07-27
DK595889A (da) 1990-05-29
ATE123940T1 (de) 1995-07-15
EP0371431A3 (en) 1991-10-09
JP2823170B2 (ja) 1998-11-11
PT92416B (pt) 1995-08-09
KR900007398A (ko) 1990-06-01
RU2097027C1 (ru) 1997-11-27
HU896191D0 (en) 1990-02-28
US5449521A (en) 1995-09-12
EP0371431A2 (en) 1990-06-06
FI895693A0 (fi) 1989-11-28
CA2004064C (en) 2000-02-08
YU221189A (en) 1991-06-30
DE68923157T2 (de) 1995-11-09
CA2004064A1 (en) 1990-05-28
IL92454A (en) 1994-06-24
IT8822770A0 (it) 1988-11-28
IL92454A0 (en) 1990-08-31
RU1837868C (ru) 1993-08-30
DK175684B1 (da) 2005-01-17
EP0371431B1 (en) 1995-06-21
HUT52366A (en) 1990-07-28
US5354560A (en) 1994-10-11

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