IN2014DN10236A - - Google Patents

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IN2014DN10236A
IN2014DN10236A IN10236DEN2014A IN2014DN10236A IN 2014DN10236 A IN2014DN10236 A IN 2014DN10236A IN 10236DEN2014 A IN10236DEN2014 A IN 10236DEN2014A IN 2014DN10236 A IN2014DN10236 A IN 2014DN10236A
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India
Prior art keywords
terpenes
methods
produced
microbial fermentation
pathway enzymes
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Wendy Chen
Fungmin Liew
Michael Koepke
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Lanzatech New Zealand Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49670710&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014DN10236(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lanzatech New Zealand Ltd filed Critical Lanzatech New Zealand Ltd
Publication of IN2014DN10236A publication Critical patent/IN2014DN10236A/en

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    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
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    • C12Y101/01267—1-Deoxy-D-xylulose-5-phosphate reductoisomerase (1.1.1.267)
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    • C12Y117/07—Oxidoreductases acting on CH or CH2 groups (1.17) with an iron-sulfur protein as acceptor (1.17.7)
    • C12Y117/07001—(E)-4-Hydroxy-3-methylbut-2-enyl-diphosphate synthase (1.17.7.1)
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    • C12Y202/01—Transketolases and transaldolases (2.2.1)
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    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01009—Acetyl-CoA C-acetyltransferase (2.3.1.9)
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    • C12Y205/0101—(2E,6E)-Farnesyl diphosphate synthase (2.5.1.10), i.e. geranyltranstransferase
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    • C12Y207/07—Nucleotidyltransferases (2.7.7)
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    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
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    • C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
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    • C12Y503/03002—Isopentenyl-diphosphate DELTA-isomerase (5.3.3.2)
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Terpenes are valuable commercial products used in a diverse number of industries. Terpenes may be produced from petrochemical sources and from terpene feed stocks such as turpentine. However these production methods are expensive unsustainable and often cause environmental problems including contributing to climate change. Microbial fermentation provides an alternative option for the production of terpenes. One or more terpenes and/or precursors can be produced by microbial fermentation of a substrate comprising CO. Recombinant microorganisms may be used in such methods. Carboxydotrophic acetogenic recombinant microorganisms can be used in such methods. The recombinant microorgnsims may contain exogenous mevalonate (MVA) pathway enzymes and/or DXS pathway enzymes for example.
IN10236DEN2014 2012-06-01 2013-06-04 IN2014DN10236A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261654412P 2012-06-01 2012-06-01
PCT/NZ2013/000095 WO2013180584A1 (en) 2012-06-01 2013-06-04 Recombinant microorganisms and uses therefor

Publications (1)

Publication Number Publication Date
IN2014DN10236A true IN2014DN10236A (en) 2015-08-07

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IN10236DEN2014 IN2014DN10236A (en) 2012-06-01 2013-06-04

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US (5) US20130323820A1 (en)
EP (3) EP3346008B1 (en)
JP (2) JP6643083B2 (en)
CN (3) CN104822823B8 (en)
DK (2) DK3346008T3 (en)
EA (1) EA028892B1 (en)
ES (2) ES2841725T3 (en)
IN (1) IN2014DN10236A (en)
PL (2) PL3346008T3 (en)
WO (1) WO2013180584A1 (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130323820A1 (en) * 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
US9783828B2 (en) 2012-10-23 2017-10-10 Sekisui Chemical Co., Ltd. Recombinant cell, and method for producing isoprene
RU2013146377A (en) * 2013-10-17 2015-04-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING ISOPRENE USING BACTERIA OF THE GENUS Bacillus
HUE051262T2 (en) 2014-01-28 2021-03-01 Lanzatech New Zealand Ltd Method of producing a recombinant microorganism
CA2936252C (en) * 2014-01-30 2019-08-20 Lanzatech New Zealand Limited Recombinant acetogenic bacterium with mutated lactate biosynthesis pathway enzyme and methods of use thereof
JP6325862B2 (en) * 2014-03-25 2018-05-16 積水化学工業株式会社 Recombinant cells and method for producing cyclic monoterpenes
JP2016059313A (en) * 2014-09-17 2016-04-25 積水化学工業株式会社 Recombinant cell, and method for producing isoprene or cyclic isoprenoid
PT3209786T (en) 2014-10-22 2023-06-26 Lanzatech Nz Inc Multi-stage bioreactor processes
PL3210012T3 (en) 2014-10-22 2024-01-15 Lanzatech Nz, Inc. Gas testing unit and method
PT3230459T (en) * 2014-12-08 2020-12-18 Lanzatech New Zealand Ltd Recombinant microorganisms exhibiting increased flux through a fermentation pathway
US10131884B2 (en) 2015-02-23 2018-11-20 Lanzatech New Zealand Limited Recombinant acetogenic bacterium for the conversion of methane to products
DE102015103608A1 (en) * 2015-03-11 2016-09-15 Basf Se Process for the microbial de novo synthesis of terpenes
US20170145441A1 (en) 2015-08-17 2017-05-25 INVISTA North America S.à.r.l. Methods, hosts, and reagents related thereto for production of unsaturated pentahydrocarbons, derivatives and intermediates thereof
US20190017076A1 (en) 2015-08-17 2019-01-17 Invista North America S.A.R.L. Methods, cells and reagents for production of isoprene, derivatives and intermediates thereof
CA3051235C (en) 2015-10-13 2022-05-03 Lanzatech New Zealand Limited Genetically engineered bacterium comprising energy-generating fermentation pathway
US20180334657A1 (en) * 2015-11-30 2018-11-22 Sekisui Chemical Co., Ltd. Recombinant cell, method for producing recombinant cell, and method for producing organic compound
US10995347B2 (en) * 2015-12-03 2021-05-04 Lanzatech New Zealand Limited Arginine supplementation to improve efficiency in gas fermenting acetogens
US10358661B2 (en) 2015-12-28 2019-07-23 Lanzatech New Zealand Limited Microorganism with modified hydrogenase activity
CA3083080C (en) 2016-02-01 2021-10-19 Lanzatech New Zealand Limited Integrated fermentation and electrolysis process
CN114908093A (en) 2016-02-26 2022-08-16 朗泽科技新西兰有限公司 CRISPR/CAS system for C1 immobilized bacteria
CN109477063A (en) 2016-05-14 2019-03-15 朗泽科技有限公司 Aldehyde with change: the active microorganism of ferredoxin oxide-reductase and correlation technique
JPWO2018070141A1 (en) * 2016-10-13 2019-08-08 積水化学工業株式会社 Obligate anaerobic acetic acid producing microorganism and recombinant microorganism
KR102000755B1 (en) * 2016-12-27 2019-07-17 한국과학기술원 A recombinant microorganism introduced exotic genes and a method for producing useful product from carbon dioxide and formic acid using the recombinant microorganism
GB201701548D0 (en) * 2017-01-31 2017-03-15 Univ Manchester Process for producing monoterpenes
US11162115B2 (en) 2017-06-30 2021-11-02 Inv Nylon Chemicals Americas, Llc Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons
WO2019006255A1 (en) 2017-06-30 2019-01-03 Invista North America S.A.R.L. Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof
MY193827A (en) 2017-09-08 2022-10-27 Lanzatech Inc Processes and systems for metabolite production using hydrogen rich c1-containing substrates
US11505809B2 (en) 2017-09-28 2022-11-22 Inv Nylon Chemicals Americas Llc Organisms and biosynthetic processes for hydrocarbon synthesis
CN109722404B (en) * 2017-10-30 2021-03-12 中国石油化工股份有限公司 Engineering strain and method for preparing farnesene by using cellulose
CA3084263A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
EP3728614A4 (en) 2017-12-19 2021-11-24 Lanzatech, Inc. Microorganisms and methods for the biological production of ethylene glycol
EP3728212A1 (en) 2017-12-21 2020-10-28 Zymergen Inc. Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
KR20200110705A (en) 2018-02-12 2020-09-24 란자테크, 인크. Process to improve carbon conversion efficiency
KR102122898B1 (en) * 2018-02-26 2020-06-15 주식회사 엠디헬스케어 Nanovesicles derived from Blautia bacteria and Use thereof
EA202092427A1 (en) 2018-04-20 2021-02-02 Ланцатек, Инк. INTERMITTED ELECTROLYSIS FLOWS
WO2020106722A1 (en) 2018-11-19 2020-05-28 Lanzatech, Inc. Integration of fermentation and gasification
CN112969795A (en) 2019-02-08 2021-06-15 朗泽科技有限公司 Process for recovering close boiling products
CN109666683B (en) * 2019-02-27 2021-10-29 昆明理工大学 Acetyl coenzyme A acetyltransferase gene RKAcaT2 and application thereof
CN113614240A (en) 2019-03-20 2021-11-05 环球生物能源公司 Improved means and methods for production of isobutene from acetyl-CoA
CN109777815B (en) * 2019-03-28 2021-10-29 昆明理工大学 HMG-CoA synthetase gene RKHMGCS and application thereof
US11772038B2 (en) 2019-07-11 2023-10-03 Lanzatech, Inc. Methods for optimizing gas utilization
CN110702821B (en) * 2019-11-26 2022-06-07 四川大学华西医院 Typing detection kit for chronic obstructive pulmonary disease
US11976310B2 (en) 2020-02-17 2024-05-07 Scientist Of Fortune S.A. Method for the incorporation of formaldehyde into biomass
WO2021248015A1 (en) 2020-06-06 2021-12-09 Lanzatech, Inc. Microorganism with knock-in at acetolactate decarboxylase gene locus
AU2022218205A1 (en) 2021-02-08 2023-05-25 Lanzatech, Inc. Recombinant microorganisms and uses therefor
TW202307202A (en) 2021-08-06 2023-02-16 美商朗澤科技有限公司 Microorganisms and methods for improved biological production of ethylene glycol
WO2023031482A1 (en) 2021-09-06 2023-03-09 Global Bioenergies Organisms producing less crotonic acid
EP4144838A1 (en) 2021-09-06 2023-03-08 Global Bioenergies Organisms producing less crotonic acid

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2002A (en) 1841-03-12 Tor and planter for plowing
US5173429A (en) 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
US5593886A (en) 1992-10-30 1997-01-14 Gaddy; James L. Clostridium stain which produces acetic acid from waste gases
EP2305825B1 (en) * 1998-07-06 2015-01-14 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
UA72220C2 (en) 1998-09-08 2005-02-15 Байоенджініерінг Рісорсиз, Інк. Water-immiscible mixture solvent/cosolvent for extracting acetic acid, a method for producing acetic acid (variants), a method for anaerobic microbial fermentation for obtaining acetic acid (variants), modified solvent and a method for obtaining thereof
ATE332390T1 (en) 2000-07-25 2006-07-15 Emmaus Foundation Inc METHOD FOR INCREASE PRODUCTION OF THE FERMENTATIVE PRODUCTION OF ETHANOL
ATE405638T1 (en) * 2001-06-06 2008-09-15 Dsm Ip Assets Bv IMPROVED ISOPRENOID PRODUCTION
US8114645B2 (en) * 2006-05-19 2012-02-14 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
US7704723B2 (en) 2006-08-31 2010-04-27 The Board Of Regents For Oklahoma State University Isolation and characterization of novel clostridial species
US8257957B2 (en) * 2006-09-26 2012-09-04 The Regents Of The University Of California Production of isoprenoids and isoprenoid precursors
EP2152854A2 (en) * 2007-05-01 2010-02-17 Acidophil LLC Methods for the direct conversion of carbon dioxide into a hydrocarbon using a metabolically engineered photosynthetic microorganism
US20090082495A1 (en) * 2007-09-20 2009-03-26 Rene Jean Zimmer Pneumatic Tire
MX302107B (en) * 2007-09-20 2012-08-08 Amyris Biotechnologies Inc Production of isoprenoids.
EP2217696B1 (en) 2007-11-13 2015-09-16 Lanzatech New Zealand Limited Novel bacteria and methods of use thereof
CA2709107A1 (en) * 2007-12-13 2009-06-18 Danisco Us Inc. Compositions and methods for producing isoprene
EP2245137B1 (en) * 2008-01-22 2017-08-16 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
WO2009111513A1 (en) * 2008-03-03 2009-09-11 Joule Biotechnologies, Inc. Engineered co2 fixing microorganisms producing carbon-based products of interest
WO2010019696A2 (en) * 2008-08-12 2010-02-18 Allylix, Inc. Method for production of isoprenoids
CA2748887A1 (en) * 2008-12-30 2010-07-08 Danisco Us Inc. Methods of producing isoprene and a co-product
TWI427149B (en) * 2009-06-17 2014-02-21 Danisco Us Inc Improved isoprene production using the dxp and mva pathway
US8759047B2 (en) * 2009-09-16 2014-06-24 Coskata, Inc. Process for fermentation of syngas from indirect gasification
US8143037B2 (en) 2010-03-19 2012-03-27 Coskata, Inc. Ethanologenic Clostridium species, Clostridium coskatii
WO2011160081A1 (en) * 2010-06-17 2011-12-22 Danisco Us Inc. Fuel compositions comprising isoprene derivatives
US8987431B2 (en) * 2010-07-01 2015-03-24 Coskata, Inc. Essential genes encoding conserved metabolic pathway function in autotrophic solventogenic clostridial species
WO2012019169A1 (en) * 2010-08-06 2012-02-09 Danisco Us Inc. Production of isoprene under neutral ph conditions
US20120045807A1 (en) * 2010-08-19 2012-02-23 Lanzatech New Zealand Limited Process for producing chemicals using microbial fermentation of substrates comprising carbon monoxide
US8759070B2 (en) * 2010-09-10 2014-06-24 University Of Delaware Recombinant clostridia that fix CO2 and CO and uses thereof
US20110236941A1 (en) 2010-10-22 2011-09-29 Lanzatech New Zealand Limited Recombinant microorganism and methods of production thereof
US20110256600A1 (en) * 2011-02-02 2011-10-20 Lanzatech New Zealand Limited Recombinant Microorganisms and Methods of Use Thereof
TWI541348B (en) 2011-02-25 2016-07-11 藍瑟科技紐西蘭有限公司 Recombinant carboxydotrophic acetogenic microorganisms and uses therefor
US20130273625A1 (en) * 2011-10-07 2013-10-17 Danisco Us Inc. Methods for increasing microbial production of isoprene, isoprenoids, and isoprenoid precursor molecules using glucose and acetate co-metabolism
WO2013181647A2 (en) * 2012-06-01 2013-12-05 Danisco Us Inc. Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms
US20130323820A1 (en) * 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
US20150152441A1 (en) 2013-11-29 2015-06-04 Lanzatech New Zealand Limited Methods and systems for improving fermentation efficiency

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