HUP0100813A2 - Enhancing the circulating half-life of antibody-based fusion proteins - Google Patents

Enhancing the circulating half-life of antibody-based fusion proteins

Info

Publication number
HUP0100813A2
HUP0100813A2 HU0100813A HUP0100813A HUP0100813A2 HU P0100813 A2 HUP0100813 A2 HU P0100813A2 HU 0100813 A HU0100813 A HU 0100813A HU P0100813 A HUP0100813 A HU P0100813A HU P0100813 A2 HUP0100813 A2 HU P0100813A2
Authority
HU
Hungary
Prior art keywords
life
antibody
fusion proteins
based fusion
circulation half
Prior art date
Application number
HU0100813A
Other languages
Hungarian (hu)
Inventor
Stephen D. Gillies
Yan Lan
Kin-Ming Lo
John Wesolowski
Original Assignee
Lexigen Pharmaceuticals Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexigen Pharmaceuticals Corporation filed Critical Lexigen Pharmaceuticals Corporation
Publication of HUP0100813A2 publication Critical patent/HUP0100813A2/en
Publication of HUP0100813A3 publication Critical patent/HUP0100813A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Above=0;>(57) A találmány tárgyát megnövelt in vivo keringésiféléletidejű ellenanyag alapú fúziós proteinek képezik, amelyekimmunglobulin (Ig) nehéz lánc legalább egy, Fc-receptorral szembenjelentős mértékben csökkent kötőaffinitást mutató részét tartalmazzákegy második, nem-Ig-proteinnel kapcsoltan, és amelyek in vivokeringési féléletideje hoszszabb, mint az össze nem kapcsolt második,nem-Ig-proteiné. A találmány tárgyát képezik továbbá eljárásokellenanyag alapú fúziós proteinek keringési féléletidejénekmeghosszabbítására, amelyek szerint, fúziós partnerként olyan nehézlánc izotípusokat alkalmaznak, melyek csökkent kötőaffinitást mutatnaka sejteken található Fc-re- ceptorok iránt; vagy géntechnológiai útonegy vagy több aminosavat módosítanak az IgG1 vagy IgG3 nehéz lánckomponensének konstans régiójában, miáltal ezen izotípusok Fc-receptoriránti affinitását csökkentik. A találmány szerinti megoldásalkalmazásával megnövelt in vivo keringési féléletidejű,ellenanyagalapú fúziós proteinek állíthatók elő. ÓAbove=0;>(57) The subject of the invention are antibody-based fusion proteins with an increased in vivo circulation half-life, which contain at least one part of an immunoglobulin (Ig) heavy chain with a significantly reduced binding affinity towards Fc-receptors linked to a second, non-Ig protein, and whose in vivo circulation half-life is longer than that of the unlinked second, non-Ig protein. The invention also relates to methods for extending the circulation half-life of antibody-based fusion proteins, according to which heavy chain isotypes are used as fusion partners, which would show a reduced binding affinity for Fc-receptors found on cells; or by genetic engineering, one or more amino acids are modified in the constant region of the heavy chain component of IgG1 or IgG3, thereby reducing the affinity of these isotypes towards the Fc receptor. By applying the solution according to the invention, antibody-based fusion proteins with an increased in vivo circulation half-life can be produced. HE

HU0100813A 1998-02-25 1999-02-24 Enhancing the circulating half-life of antibody-based fusion proteins HUP0100813A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7588798P 1998-02-25 1998-02-25
PCT/US1999/003966 WO1999043713A1 (en) 1998-02-25 1999-02-24 Enhancing the circulating half-life of antibody-based fusion proteins

Publications (2)

Publication Number Publication Date
HUP0100813A2 true HUP0100813A2 (en) 2001-06-28
HUP0100813A3 HUP0100813A3 (en) 2003-08-28

Family

ID=22128576

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100813A HUP0100813A3 (en) 1998-02-25 1999-02-24 Enhancing the circulating half-life of antibody-based fusion proteins

Country Status (12)

Country Link
EP (1) EP1060194A1 (en)
JP (1) JP2002505086A (en)
CN (1) CN1204147C (en)
AU (1) AU758240B2 (en)
BR (1) BR9908226A (en)
CA (1) CA2320403A1 (en)
CZ (1) CZ20003099A3 (en)
HK (1) HK1036286A1 (en)
HU (1) HUP0100813A3 (en)
NO (1) NO20004218L (en)
PL (1) PL199659B1 (en)
WO (1) WO1999043713A1 (en)

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WO1999043713A1 (en) 1999-09-02
AU2784299A (en) 1999-09-15
AU758240B2 (en) 2003-03-20
CA2320403A1 (en) 1999-09-02
EP1060194A1 (en) 2000-12-20
PL342497A1 (en) 2001-06-04
JP2002505086A (en) 2002-02-19
HUP0100813A3 (en) 2003-08-28
CZ20003099A3 (en) 2002-04-17
PL199659B1 (en) 2008-10-31
CN1291995A (en) 2001-04-18
NO20004218L (en) 2000-10-24
NO20004218D0 (en) 2000-08-23
CN1204147C (en) 2005-06-01
HK1036286A1 (en) 2001-12-28
BR9908226A (en) 2000-10-24

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