GB1344663A - Isoindoline compounds - Google Patents

Isoindoline compounds

Info

Publication number
GB1344663A
GB1344663A GB4991871A GB4991871A GB1344663A GB 1344663 A GB1344663 A GB 1344663A GB 4991871 A GB4991871 A GB 4991871A GB 4991871 A GB4991871 A GB 4991871A GB 1344663 A GB1344663 A GB 1344663A
Authority
GB
United Kingdom
Prior art keywords
alkyl
compounds
aminoalkyl
nov
analogous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4991871A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlo Erba SpA filed Critical Carlo Erba SpA
Publication of GB1344663A publication Critical patent/GB1344663A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1344663 Isoindolinone derivatives CARLO ERBA SpA 27 Oct 1971 [5 Nov 1970 10 Nov 1970] 49918/71 Heading C2C The invention comprises compounds of formula wherein R is H or C 1-4 alkyl, R 1 is H, alkyl or (CH 2 ) n NR<SP>2</SP>R<SP>3</SP>, n is 1 or 2 and R<SP>2</SP>, R<SP>3</SP> are each H or C 1-4 alkyl, and their physiologically acceptable addition salts (where R 1 is H or aminoalkyl). In examples, these compounds are prepared (1) when R 1 is H, by hydrolysing (a) the corresponding esters or nitriles (II), or (b) the analogous iminoisoindolinecarboxylic acids or alkyl esters; (2) when R 1 is alkyl, by (a) esterifying the acids, (b) reducing the analogous phthalimide compounds, (c) reacting the corresponding alkyl p-aminophenylacetates with phthalide, thiophthalide or phthalaldehyde; (3) when R 1 is aminoalkyl, by reacting the corresponding acid chlorides with R<SP>2</SP>R<SP>3</SP>N(CH 2 ) n OH. Also prepared are the iminoisoindoline and phthalimide analogues of II. Therapeutic compositions having analgesic and anti-inflammatory activity comprise compounds of the above formula, and may be administered orally, parenterally, rectally or topically.
GB4991871A 1970-11-10 1971-10-27 Isoindoline compounds Expired GB1344663A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT3151470 1970-11-10

Publications (1)

Publication Number Publication Date
GB1344663A true GB1344663A (en) 1974-01-23

Family

ID=11233714

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4991871A Expired GB1344663A (en) 1970-11-10 1971-10-27 Isoindoline compounds

Country Status (3)

Country Link
GB (1) GB1344663A (en)
SU (1) SU448644A3 (en)
YU (1) YU34989B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0047674A1 (en) * 1980-09-10 1982-03-17 Hisamitsu Pharmaceutical Co., Inc. Novel process for preparing isoindolin derivatives
GB2204579A (en) * 1987-03-10 1988-11-16 Erba Carlo Spa Optically active oxo-isoindolinyl derivatives
US7244730B2 (en) 2001-04-19 2007-07-17 Eisai Co., Ltd 2-iminopyrrolidine derivatives
US7375236B2 (en) 2003-02-19 2008-05-20 Eisai Co., Ltd. Methods for producing cyclic benzamidine derivatives
CN114249801A (en) * 2021-12-06 2022-03-29 南开大学 Cyclopeptide compound and preparation method and application thereof
CN114634440A (en) * 2020-12-16 2022-06-17 杭州中美华东制药有限公司 Indobufen crystal form X and crystal form D and preparation method thereof

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0047674A1 (en) * 1980-09-10 1982-03-17 Hisamitsu Pharmaceutical Co., Inc. Novel process for preparing isoindolin derivatives
GB2204579A (en) * 1987-03-10 1988-11-16 Erba Carlo Spa Optically active oxo-isoindolinyl derivatives
AU605253B2 (en) * 1987-03-10 1991-01-10 Farmitalia Carlo Erba S.R.L. Optically active oxo-isoindolinyl derivatives
AT392068B (en) * 1987-03-10 1991-01-25 Erba Carlo Spa OPTICALLY ACTIVE OXO-ISOINDOLINYL DERIVATIVES
GB2204579B (en) * 1987-03-10 1991-01-30 Erba Carlo Spa Optically active oxo-isoindolinyl derivatives
US7304083B2 (en) 2001-04-19 2007-12-04 Eisai R&D Management Co., Ltd. 2-iminoimidazole derivatives (2)
US7244730B2 (en) 2001-04-19 2007-07-17 Eisai Co., Ltd 2-iminopyrrolidine derivatives
US7476688B2 (en) 2001-04-19 2009-01-13 Eisai R&D Management Co., Ltd. Cyclic amidine derivatives
US7375236B2 (en) 2003-02-19 2008-05-20 Eisai Co., Ltd. Methods for producing cyclic benzamidine derivatives
CN114634440A (en) * 2020-12-16 2022-06-17 杭州中美华东制药有限公司 Indobufen crystal form X and crystal form D and preparation method thereof
CN114634440B (en) * 2020-12-16 2023-05-09 杭州中美华东制药有限公司 Indolibuprofen crystal form X and crystal form D and preparation method thereof
CN116082218A (en) * 2020-12-16 2023-05-09 杭州中美华东制药有限公司 Indolibufen crystal form D and preparation method thereof
CN116082218B (en) * 2020-12-16 2023-08-18 杭州中美华东制药有限公司 Indolibufen crystal form D and preparation method thereof
CN114249801A (en) * 2021-12-06 2022-03-29 南开大学 Cyclopeptide compound and preparation method and application thereof

Also Published As

Publication number Publication date
YU34989B (en) 1980-06-30
YU222478A (en) 1979-12-31
SU448644A3 (en) 1974-10-30

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Legal Events

Date Code Title Description
PS Patent sealed
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PE20 Patent expired after termination of 20 years