ES2567279T3 - Aparato para una estimulación eléctrica del córtex - Google Patents
Aparato para una estimulación eléctrica del córtex Download PDFInfo
- Publication number
- ES2567279T3 ES2567279T3 ES09305432.8T ES09305432T ES2567279T3 ES 2567279 T3 ES2567279 T3 ES 2567279T3 ES 09305432 T ES09305432 T ES 09305432T ES 2567279 T3 ES2567279 T3 ES 2567279T3
- Authority
- ES
- Spain
- Prior art keywords
- virtual
- field
- neural
- cortex
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0529—Electrodes for brain stimulation
- A61N1/0531—Brain cortex electrodes
Landscapes
- Health & Medical Sciences (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Developmental Disabilities (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Electrotherapy Devices (AREA)
Abstract
Un aparato para la estimulación del córtex, que comprende: - una matriz de electrodos (8) que incluye un número n de electrodos (8b) adaptados para implantarse en el córtex (6) de un paciente, siendo n al menos 1; - un sistema de control (7) que controla dicha matriz de electrodos (8), estando adaptado dicho sistema de control para: (a) la recogida de un número n de señales eléctricas, cada una en un electrodo (8b) respectivo de dicha matriz de electrodos (8); caracterizado por que dicho sistema de control está adaptado para: (b) la determinación de n señales de estimulación, mediante un campo neuronal virtual que tiene una matriz virtual de n puntos que corresponden a cada electrodo de la matriz de electrodos que recoge dichas señales eléctricas, estando configurada dicha matriz virtual para recibir la señal recogida como una entrada en cada uno de los n puntos y estando adaptado dicho campo neuronal virtual para controlar el espectro de frecuencia de la actividad neuronal en el córtex, caracterizado por que cada señal de estimulación se determina mediante un valor del potencial virtual en cada punto de la matriz virtual usando la siguiente fórmula:**Fórmula** en la que: - L es un operador igual a**Fórmula** - Va es un potencial en el campo neuronal virtual; - x es una posición espacial en el campo neuronal virtual; - t es el tiempo; - Q es un dominio espacial del campo neuronal; - d(x,y) es una distancia entre dos posiciones espaciales x, y en el dominio espacial Ω. - v es una velocidad de propagación de una señal en el campo neuronal virtual; - ßa es una fuerza sináptica en el campo neuronal virtual; - Wa(d(x,y)) es un núcleo de conectividad del campo virtual; - S(V) es una función sigmoide que proporciona una correspondencia entre un potencial V y una tasa de disparo correspondiente de las neuronas; - θ es un umbral de disparo; - I(x,t) es una función de las señales eléctricas Vr(x,t) recogidas a través de los electrodos (8b) y aplicadas a los puntos de la matriz virtual en el campo neuronal virtual. en la que:**Fórmula** en las que: - ßar es una fuerza sináptica entre los campos neuronales real y virtual; - War es un núcleo de conectividad entre los campos neuronales real y virtual; -**Fórmula** es un retardo; - ae/ai son potenciales sinápticos excitatorios/inhibitorios respectivamente; - r es una relación de intervalos espaciales entre las fibras excitatoria e inhibitoria; - fmáx es una tasa de descarga máxima de neuronas en el campo neuronal; y λ es un parámetro no dimensional. (c) la emisión de dichas señales de estimulación en el córtex, respectivamente en los electrodos (8b) de dicha matriz de electrodos (8) correspondientes a los puntos de la matriz virtual
Description
Claims (1)
-
imagen1 imagen2
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09305432.8A EP2251062B1 (en) | 2009-05-14 | 2009-05-14 | Apparatus for electrical cortex stimulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2567279T3 true ES2567279T3 (es) | 2016-04-21 |
Family
ID=41202842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09305432.8T Active ES2567279T3 (es) | 2009-05-14 | 2009-05-14 | Aparato para una estimulación eléctrica del córtex |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8886324B2 (es) |
| EP (1) | EP2251062B1 (es) |
| JP (1) | JP5577402B2 (es) |
| CA (1) | CA2761637C (es) |
| ES (1) | ES2567279T3 (es) |
| WO (1) | WO2010130538A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2567279T3 (es) | 2009-05-14 | 2016-04-21 | Institut Polytechnique De Bordeaux | Aparato para una estimulación eléctrica del córtex |
| US10617361B2 (en) * | 2010-11-09 | 2020-04-14 | Osaka University | Casing of implantable device and implantable device, method for manufacturing casing of implantable device, and method for supporting treatment using implantable device |
| US11229789B2 (en) | 2013-05-30 | 2022-01-25 | Neurostim Oab, Inc. | Neuro activator with controller |
| JP2016523125A (ja) | 2013-05-30 | 2016-08-08 | グラハム エイチ． クリーシー | 局所神経性刺激 |
| US11077301B2 (en) | 2015-02-21 | 2021-08-03 | NeurostimOAB, Inc. | Topical nerve stimulator and sensor for bladder control |
| CN111601636A (zh) | 2017-11-07 | 2020-08-28 | Oab神经电疗科技公司 | 具有自适应电路的非侵入性神经激活器 |
| KR20220025834A (ko) | 2019-06-26 | 2022-03-03 | 뉴로스팀 테크놀로지스 엘엘씨 | 적응적 회로를 갖는 비침습적 신경 활성화기 |
| EP4017580A4 (en) | 2019-12-16 | 2023-09-06 | Neurostim Technologies LLC | NON-INVASIVE NERVE ACTIVATOR WITH AMPLIFIED CHARGE DISTRIBUTION |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5215088A (en) * | 1989-11-07 | 1993-06-01 | The University Of Utah | Three-dimensional electrode device |
| US7672730B2 (en) * | 2001-03-08 | 2010-03-02 | Advanced Neuromodulation Systems, Inc. | Methods and apparatus for effectuating a lasting change in a neural-function of a patient |
| DE102004060514A1 (de) | 2004-12-16 | 2006-06-29 | Forschungszentrum Jülich GmbH | Verfahren und Vorrichtung zur Desynchronisation neuronaler Hirnaktivität, Steuerung, sowie Verfahren zur Behandlung neuronaler und/oder psychiatrischer Erkrankungen |
| US8788044B2 (en) * | 2005-01-21 | 2014-07-22 | Michael Sasha John | Systems and methods for tissue stimulation in medical treatment |
| US8825166B2 (en) * | 2005-01-21 | 2014-09-02 | John Sasha John | Multiple-symptom medical treatment with roving-based neurostimulation |
| WO2009097493A2 (en) * | 2008-01-30 | 2009-08-06 | New York University | Cortical electrode array and method for stimulating and recording brain activity |
| ES2567279T3 (es) | 2009-05-14 | 2016-04-21 | Institut Polytechnique De Bordeaux | Aparato para una estimulación eléctrica del córtex |
-
2009
- 2009-05-14 ES ES09305432.8T patent/ES2567279T3/es active Active
- 2009-05-14 EP EP09305432.8A patent/EP2251062B1/en active Active
-
2010
- 2010-04-21 US US13/320,177 patent/US8886324B2/en active Active
- 2010-04-21 CA CA2761637A patent/CA2761637C/en active Active
- 2010-04-21 WO PCT/EP2010/055252 patent/WO2010130538A1/en active Application Filing
- 2010-04-21 JP JP2012510190A patent/JP5577402B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2761637A1 (en) | 2010-11-18 |
| EP2251062B1 (en) | 2016-01-13 |
| US20120109252A1 (en) | 2012-05-03 |
| WO2010130538A1 (en) | 2010-11-18 |
| JP2012526572A (ja) | 2012-11-01 |
| CA2761637C (en) | 2017-10-17 |
| EP2251062A1 (en) | 2010-11-17 |
| JP5577402B2 (ja) | 2014-08-20 |
| US8886324B2 (en) | 2014-11-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2567279T3 (es) | Aparato para una estimulación eléctrica del córtex | |
| Pulver et al. | Imaging fictive locomotor patterns in larval Drosophila | |
| Proville et al. | Cerebellum involvement in cortical sensorimotor circuits for the control of voluntary movements | |
| Vaughan et al. | Neural pathways for the detection and discrimination of conspecific song in D. melanogaster | |
| Zwart et al. | Selective inhibition mediates the sequential recruitment of motor pools | |
| Petersen et al. | Synaptic computation and sensory processing in neocortical layer 2/3 | |
| Reid | From functional architecture to functional connectomics | |
| CN106264569B (zh) | 一种基于观察性恐惧习得的共情神经实验系统 | |
| CN104523232A (zh) | 一种小型动物恐惧行为检测系统 | |
| RU2014105665A (ru) | Способ и система оценки сотрясения головного мозга | |
| BR112017022422A2 (pt) | detecção de atividade em nervos periféricos | |
| Niell | Exploring the next frontier of mouse vision | |
| Machnik et al. | The Mauthner cell in a fish with top-performance and yet flexibly tuned C-starts. II. Physiology | |
| Lin et al. | Equations governing dynamics of excitation and inhibition in the mouse corticothalamic network | |
| Tuthill et al. | Four to foxtrot: how visual motion is computed in the fly brain | |
| Dewell et al. | Escape behavior: linking neural computation to action | |
| Hayashi et al. | Acquisition of logicality in living neuronal networks and its operation to fuzzy bio-robot system | |
| Navarro-Guerrero et al. | A neurocomputational amygdala model of auditory fear conditioning: A hybrid system approach | |
| Bleckmann et al. | Nature as a model for technical sensors | |
| RU2015119809A (ru) | Способ и устройство возделывания агрокультур по управляемым зонам | |
| 袁丰 et al. | A multi-channel analog IC for in vitro neural recording | |
| Nordström et al. | Invertebrate vision: peripheral adaptation to repeated object motion | |
| Costalago Meruelo et al. | Si elegans: A computational model of C. elegans muscle response to light | |
| Macktoobian | Bi-directioal Motion Detection: A Neural Intelligent Model For Perception of Cognitive Robots | |
| Eriksson et al. | Cortical activity at different time scales: high-pass filtering separates motor planning and execution |