EP1626981A4 - Proteines protegees contre la dipeptidylpeptidase - Google Patents

Proteines protegees contre la dipeptidylpeptidase

Info

Publication number
EP1626981A4
EP1626981A4 EP04717362A EP04717362A EP1626981A4 EP 1626981 A4 EP1626981 A4 EP 1626981A4 EP 04717362 A EP04717362 A EP 04717362A EP 04717362 A EP04717362 A EP 04717362A EP 1626981 A4 EP1626981 A4 EP 1626981A4
Authority
EP
European Patent Office
Prior art keywords
dipeptidyl
peptidase
protected proteins
proteins
protected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04717362A
Other languages
German (de)
English (en)
Other versions
EP1626981A2 (fr
Inventor
Homayoun Sadeghi
Christopher P Prior
David J Ballance
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biorexis Technology Inc
Original Assignee
Biorexis Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/378,094 external-priority patent/US7176278B2/en
Application filed by Biorexis Pharmaceutical Corp filed Critical Biorexis Pharmaceutical Corp
Publication of EP1626981A2 publication Critical patent/EP1626981A2/fr
Publication of EP1626981A4 publication Critical patent/EP1626981A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP04717362A 2003-03-04 2004-03-04 Proteines protegees contre la dipeptidylpeptidase Withdrawn EP1626981A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/378,094 US7176278B2 (en) 2001-08-30 2003-03-04 Modified transferrin fusion proteins
PCT/US2003/026818 WO2004020405A2 (fr) 2002-08-30 2003-08-28 Proteines de fusion de transferrine modifiees
PCT/US2004/006462 WO2004078777A2 (fr) 2003-03-04 2004-03-04 Proteines protegees contre la dipeptidylpeptidase

Publications (2)

Publication Number Publication Date
EP1626981A2 EP1626981A2 (fr) 2006-02-22
EP1626981A4 true EP1626981A4 (fr) 2006-11-22

Family

ID=32965093

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04717362A Withdrawn EP1626981A4 (fr) 2003-03-04 2004-03-04 Proteines protegees contre la dipeptidylpeptidase

Country Status (2)

Country Link
EP (1) EP1626981A4 (fr)
WO (1) WO2004078777A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107406490A (zh) * 2015-01-23 2017-11-28 诺华股份有限公司 具有改善的半衰期的合成apelin脂肪酸缀合物

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US20050272652A1 (en) 1999-03-29 2005-12-08 Gault Victor A Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
US8129504B2 (en) 2001-08-30 2012-03-06 Biorexis Technology, Inc. Oral delivery of modified transferrin fusion proteins
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US8263545B2 (en) 2005-02-11 2012-09-11 Amylin Pharmaceuticals, Inc. GIP analog and hybrid polypeptides with selectable properties
NZ561361A (en) 2005-02-11 2010-02-26 Amylin Pharmaceuticals Inc GIP hybrid polypeptides with at least two hormonal activities
EP1926747A1 (fr) 2005-08-12 2008-06-04 Schering Corporation Fusions de mcp1
EP1942898B2 (fr) 2005-09-14 2014-05-14 Takeda Pharmaceutical Company Limited Inhibiteurs de la dipeptidyl peptidase permettant de traiter le diabete
CN102675221A (zh) 2005-09-16 2012-09-19 武田药品工业株式会社 用于制备嘧啶二酮衍生物的方法中的中间体
CA2628241C (fr) 2005-11-07 2016-02-02 Indiana University Research And Technology Corporation Analogues de glucagon a solubilite et a stabilite physiologiques ameliorees
EP2364735A3 (fr) 2005-12-16 2012-04-11 Nektar Therapeutics Conjugé de GLP-1 et de PEG ramafié
CA2646598C (fr) 2006-03-21 2014-08-19 Amylin Pharmaceuticals, Inc. Conjugues inhibiteur de peptidase-peptide et procedes d'utilisation de ceux-ci
WO2007112347A1 (fr) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Inhibiteurs de la dipeptidyl peptidase
WO2007132291A2 (fr) * 2006-05-15 2007-11-22 Digilab, Inc. Biomarqueurs pour une préforme de diabète de type 2 et méthodes de détection de la présence ou de l'absence d'une préforme du diabète de type 2
CN101501209B (zh) 2006-06-21 2013-06-05 百奥勤有限公司 具有促胰岛素活性的生物活性多肽的制备方法
AU2007278994B2 (en) 2006-07-24 2013-08-15 Biorexis Pharmaceutical Corporation Exendin fusion proteins
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
AU2007331195A1 (en) 2006-12-12 2008-06-19 Biorexis Pharmaceutical Corporation Transferrin fusion protein libraries
US7544365B2 (en) * 2006-12-14 2009-06-09 The Hospital For Sick Children TRPV1+ sensory neurons control of β-cells stress and islet inflammation in diabetes
SG177953A1 (en) 2007-01-05 2012-02-28 Univ Indiana Res & Tech Corp Glucagon analogs exhibiting enhanced solubility in physiological ph buffers
NZ578948A (en) 2007-02-15 2012-03-30 Univ Indiana Res & Tech Corp Glucagon/glp-1 receptor co-agonists
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
EP2195034A2 (fr) 2007-09-27 2010-06-16 Amylin Pharmaceuticals, Inc. Conjugués inhibiteurs de peptide/peptidase et leurs procédés de fabrication et d'utilisation
US8981047B2 (en) 2007-10-30 2015-03-17 Indiana University Research And Technology Corporation Glucagon antagonists
JP5771005B2 (ja) 2007-10-30 2015-08-26 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ グルカゴンアンタゴニスト及びｇｌｐ−１アゴニスト活性を示す化合物
AU2009210570B2 (en) 2008-01-30 2014-11-20 Indiana University Research And Technology Corporation Ester-based insulin prodrugs
TWI541023B (zh) 2008-06-17 2016-07-11 印第安納大學科技研究公司 在生理ｐｈ緩衝液中呈現增強之溶解度及穩定性之升糖激素類似物
PE20100056A1 (es) 2008-06-17 2010-01-26 Univ Indiana Res & Tech Corp Analogos de glucagon como agonistas gip
AR072160A1 (es) 2008-06-17 2010-08-11 Univ Indiana Res & Tech Corp Co-agonistas del receptor de glucagon/glp-1
JP2012512903A (ja) 2008-12-19 2012-06-07 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション アミド系グルカゴンスーパーファミリーペプチドプロドラッグ
WO2010080606A1 (fr) 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Analogues d'insuline
CA2744558A1 (fr) 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Promedicaments insuliniques a base d'amide
IN2012DN00377A (fr) 2009-06-16 2015-08-21 Univ Indiana Res & Tech Corp
US8703701B2 (en) 2009-12-18 2014-04-22 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
WO2011094337A1 (fr) 2010-01-27 2011-08-04 Indiana University Research And Technology Corporation Conjugués d'antagoniste du glucagon et d'agoniste du gip et compositions pour le traitement de troubles métaboliques et de l'obésité
JP6121323B2 (ja) 2010-05-13 2017-05-10 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ 核内ホルモン受容体の活性を示すグルカゴンスーパーファミリーのペプチド
MX2012013005A (es) 2010-05-13 2013-02-26 Univ Indiana Res & Tech Corp Peptidos de la superfamilia de glucagon que presentan actividad del receptor acoplado a proteinas g.
AU2011268327B2 (en) 2010-06-16 2016-02-25 Indiana University Research And Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
WO2011163462A2 (fr) 2010-06-24 2011-12-29 Indiana University Research And Technology Corporation Promédicaments insuliniques à base d'amide
AR084020A1 (es) 2010-11-30 2013-04-17 Genentech Inc Anticuerpos para el receptor de la barrera hematoencefalica de baja afinidad y sus usos
WO2012088116A2 (fr) 2010-12-22 2012-06-28 Indiana University Research And Technology Corporation Analogues du glucagon présentant une activité de récepteur de gip
RU2014101697A (ru) 2011-06-22 2015-07-27 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Коагонисты рецепторов глюкагона/glp-1
PE20140724A1 (es) 2011-06-22 2014-07-10 Univ Indiana Res & Tech Corp Coagonistas del receptor de glucagon/glp-1
CA2847246A1 (fr) 2011-11-17 2013-05-23 Indiana University Research And Technology Corporation Peptides de la superfamille du glucagon presentant une action sur les recepteurs aux glucocorticoides
US9573987B2 (en) 2011-12-20 2017-02-21 Indiana University Research And Technology Corporation CTP-based insulin analogs for treatment of diabetes
JP6311708B2 (ja) 2012-06-21 2018-04-18 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ Ｇｉｐ受容体活性を示すグルカゴンアナローグ
WO2014052451A2 (fr) 2012-09-26 2014-04-03 Indiana University Research And Technology Corporation Dimères analogues de l'insuline
AU2014241743B2 (en) 2013-03-14 2018-07-05 Indiana University Research And Technology Corporation Insulin-incretin conjugates
EP3197912B1 (fr) 2014-09-24 2023-01-04 Indiana University Research & Technology Corporation Promédicaments insuliniques à base d'amide lipidique
US10232020B2 (en) 2014-09-24 2019-03-19 Indiana University Research And Technology Corporation Incretin-insulin conjugates
CN109053899B (zh) * 2017-12-22 2021-11-16 湖南远泰生物技术有限公司 一种含人转铁蛋白抗原表位序列的嵌合体抗原受体
EP4364751A2 (fr) 2018-04-05 2024-05-08 Sun Pharmaceutical Industries Limited Nouveaux analogues de glp-1

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Publication number Priority date Publication date Assignee Title
WO1999043707A1 (fr) * 1998-02-27 1999-09-02 Novo Nordisk A/S Derives de glp-1 modifies a l'extremite n-terminale
WO1999046283A1 (fr) * 1998-03-09 1999-09-16 Zealand Pharmaceuticals A/S Conjugues peptidiques pharmacologiquement actifs ayant une tendance reduite a l'hydrolyse enzymatique
EP0978565A1 (fr) * 1998-01-30 2000-02-09 Suntory Limited Procede de production de peptide au moyen d'un peptide accessoire
WO2001004156A1 (fr) * 1999-07-12 2001-01-18 Zealand Pharmaceuticals A/S Peptides abaissant les niveaux de glycemie
WO2001036643A1 (fr) * 1999-11-19 2001-05-25 Transkaryotic Therapies, Inc. Produit d'assemblage d'acides nucleiques optimisant la production de produits
WO2003016349A1 (fr) * 2001-07-19 2003-02-27 Shanghai Hua-Yi Bio-Tech Lab Methode de production d'un peptide 1 de type glucagon (glp-1) 7-36 et d'un analogue de glp-1
US20030221201A1 (en) * 2001-08-30 2003-11-27 Biorexis Pharmaceutical Corporation Modified transferrin fusion proteins

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EP0978565A1 (fr) * 1998-01-30 2000-02-09 Suntory Limited Procede de production de peptide au moyen d'un peptide accessoire
WO1999043707A1 (fr) * 1998-02-27 1999-09-02 Novo Nordisk A/S Derives de glp-1 modifies a l'extremite n-terminale
WO1999046283A1 (fr) * 1998-03-09 1999-09-16 Zealand Pharmaceuticals A/S Conjugues peptidiques pharmacologiquement actifs ayant une tendance reduite a l'hydrolyse enzymatique
WO2001004156A1 (fr) * 1999-07-12 2001-01-18 Zealand Pharmaceuticals A/S Peptides abaissant les niveaux de glycemie
WO2001036643A1 (fr) * 1999-11-19 2001-05-25 Transkaryotic Therapies, Inc. Produit d'assemblage d'acides nucleiques optimisant la production de produits
WO2003016349A1 (fr) * 2001-07-19 2003-02-27 Shanghai Hua-Yi Bio-Tech Lab Methode de production d'un peptide 1 de type glucagon (glp-1) 7-36 et d'un analogue de glp-1
EP1408050A1 (fr) * 2001-07-19 2004-04-14 Shanghai Hua-Yi Bio-Tech Lab Methode de production d'un peptide 1 de type glucagon (glp-1) 7-36 et d'un analogue de glp-1
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ADELHORST K ET AL: "STRUCTURE-ACTIVITY STUDIES OF GLUCAGON-LIKE PEPTIDE-1", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 269, no. 9, 4 March 1994 (1994-03-04), pages 6275 - 6278, XP002045291, ISSN: 0021-9258 *
KAWAI K ET AL: "THE BIOLOGICAL EFFECTS OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) AND ITS STRUCTURE-ACTIVITY RELATIONSHIP", BIOMEDICAL RESEARCH, vol. 9, no. SUPPL 3, 1988, pages 213 - 217, XP000574772 *
KIEFFER T J ET AL: "DEGRADATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE AND TRUNCATED GLUCAGON-LIKE PEPTIDE 1 IN VITRO AND IN VIVO BY DIPEPTIDYL PEPTIDASE IV", ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 136, no. 8, 1 August 1995 (1995-08-01), pages 3585 - 3596, XP000574863, ISSN: 0013-7227 *
KNUDSEN LOTTE B ET AL: "Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, no. 9, 4 May 2000 (2000-05-04), pages 1664 - 1669, XP002201014, ISSN: 0022-2623 *
OHNEDA A ET AL: "THE STRUCTURE-FUNCTION RELATIONSHIP OF GLP-1 RELATED PEPTIDES IN THE ENDOCRINE FUNCTION OF THE CANINE PANCREAS", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, TOHOKU UNIVERSITY MEDICAL PRESS, SENDAI, JP, vol. 165, no. 3, November 1991 (1991-11-01), pages 209 - 221, XP008014886, ISSN: 0040-8727 *
SVETLANA MOJSOV: "STRUCTURAL REQUIREMENTS FOR BIOLOGICAL ACTIVITY OF GLUCAGON-LIKE PEPTIDE-I", INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, MUNKSGAARD, COPENHAGEN, DK, vol. 40, no. 3 / 4, 1 September 1992 (1992-09-01), pages 333 - 343, XP000311244, ISSN: 0367-8377 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107406490A (zh) * 2015-01-23 2017-11-28 诺华股份有限公司 具有改善的半衰期的合成apelin脂肪酸缀合物

Also Published As

Publication number Publication date
WO2004078777A2 (fr) 2004-09-16
EP1626981A2 (fr) 2006-02-22
WO2004078777A3 (fr) 2006-02-16

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