EA200600137A1 - Способ получения аморфной формы ингибитора агрегации тромбоцитов - Google Patents

Способ получения аморфной формы ингибитора агрегации тромбоцитов

Info

Publication number
EA200600137A1
EA200600137A1 EA200600137A EA200600137A EA200600137A1 EA 200600137 A1 EA200600137 A1 EA 200600137A1 EA 200600137 A EA200600137 A EA 200600137A EA 200600137 A EA200600137 A EA 200600137A EA 200600137 A1 EA200600137 A1 EA 200600137A1
Authority
EA
Eurasian Patent Office
Prior art keywords
amorphous form
inhibitor
platelet aggregation
producing amorphous
producing
Prior art date
Application number
EA200600137A
Other languages
English (en)
Inventor
Петер Котаи Надь
Дьюла Шимиг
Йожеф Баркоци
Тамаш Грегор
Бела Фаркаш
Дьёрдь Верецкеине Донат
Кальман Надь
Дьюлане Кертвейэшши
Жужанна Сент-Кирайи
Original Assignee
Эгиш Дьёдьсердьяр Рт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0302029A external-priority patent/HU0302029D0/hu
Priority claimed from HU0401269A external-priority patent/HU226565B1/hu
Application filed by Эгиш Дьёдьсердьяр Рт. filed Critical Эгиш Дьёдьсердьяр Рт.
Publication of EA200600137A1 publication Critical patent/EA200600137A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к новому способу получения аморфной формы метил-(S)-(+)-(2-хлорфенил)-2-(6,7-дигидро-4Н-тиено[3,2-с]пиридин-5-ил-ацетата гидросульфата формулы (I)
EA200600137A 2003-07-02 2004-06-30 Способ получения аморфной формы ингибитора агрегации тромбоцитов EA200600137A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0302029A HU0302029D0 (en) 2003-07-02 2003-07-02 Amorphous form of an anticoagulant agent
HU0401269A HU226565B1 (en) 2004-06-23 2004-06-23 Process for the production of the amorphous form of clopidogrel hydrogen sulfate
PCT/HU2004/000069 WO2005003138A2 (en) 2003-07-02 2004-06-30 Process for the preparation of amorphous form of a platelet aggregation inhibitor drug

Publications (1)

Publication Number Publication Date
EA200600137A1 true EA200600137A1 (ru) 2006-06-30

Family

ID=89985325

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600137A EA200600137A1 (ru) 2003-07-02 2004-06-30 Способ получения аморфной формы ингибитора агрегации тромбоцитов

Country Status (11)

Country Link
US (1) US7396931B2 (ru)
EP (1) EP1648903A2 (ru)
JP (1) JP2007516166A (ru)
KR (1) KR20060026121A (ru)
BG (1) BG109428A (ru)
CA (1) CA2530446A1 (ru)
CZ (1) CZ200660A3 (ru)
EA (1) EA200600137A1 (ru)
PL (1) PL378711A1 (ru)
SK (1) SK50112006A3 (ru)
WO (1) WO2005003138A2 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7943567B2 (en) 2004-01-30 2011-05-17 E.I. Du Pont De Nemours And Company Production processes and systems, compositions, surfactants, monomer units, metal complexes, phosphate esters, glycols, aqueous film forming foams, and foam stabilizers
US8318656B2 (en) 2007-07-03 2012-11-27 E. I. Du Pont De Nemours And Company Production processes and systems, compositions, surfactants, monomer units, metal complexes, phosphate esters, glycols, aqueous film forming foams, and foam stabilizers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2779726B1 (fr) 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
CN100338068C (zh) 2001-01-24 2007-09-19 卡地拉健康护理有限公司 制备氯吡格雷的方法
GB0125708D0 (en) * 2001-10-26 2001-12-19 Generics Uk Ltd Novel compounds and processes
ES2316650T3 (es) * 2001-12-18 2009-04-16 Teva Pharmaceutical Industries Ltd. Polimorfos de hidrogenosulfato de clopidogrel.
EP1603920A1 (en) 2003-03-12 2005-12-14 Cadila Healthcare Ltd. Polymorph and amorphous form of (s)-(+)-clopidogrel bisulfate

Also Published As

Publication number Publication date
WO2005003138A3 (en) 2005-03-24
CZ200660A3 (cs) 2006-05-17
US7396931B2 (en) 2008-07-08
PL378711A1 (pl) 2006-05-15
KR20060026121A (ko) 2006-03-22
SK50112006A3 (sk) 2006-05-04
CA2530446A1 (en) 2005-01-13
BG109428A (en) 2006-10-31
WO2005003138A2 (en) 2005-01-13
EP1648903A2 (en) 2006-04-26
US20070117837A1 (en) 2007-05-24
JP2007516166A (ja) 2007-06-21

Similar Documents

Publication Publication Date Title
RS51401B (en) TIENO [3,2-D] PIRIMIDINSKI DERIVAT KOJI JE KORISTAN KAO INHIBITOR P13K
TW200718420A (en) Formulation of a thienopyridine platelet aggregation inhibitor
BR0318449A (pt) processo para fabricação de (+)-(s)-clopidogrel bissulfato forma-i
CY1109740T1 (el) Νεα μεθοδος συνθεσης παραγωγων της 1,3,4,5 -τετραϋδρο-2η- 3-βενζαζεπιν-2-ονης και εφαρμογη στη συνθεση της ιβαβραδινης και των αλατων προσθηκης της σε ενα φαρμακευτικως αποδεκτο οξυ
YU69604A (sh) Polimorfi klopidogrel hlorovodonika i njihova upotreba kao antitrombnih jedinjenja
EA200601260A1 (ru) Синтетические соединения, пригодные в качестве агентов формирования клубеньков бобовых растений и способы их получения
BR0207302A (pt) Trifluorometilpurinas como inibidores da fosfodiesterase 4
RS51210B (sr) Dobijanje pregaballina i srodnih jedinjenja
MX2008013724A (es) Proceso para la preparacion de formas polimorficas de hidrogeno sulfato clopidrogel.
MY141853A (en) 1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiphlogistics
BG109429A (en) A METHOD FOR OBTAINING A CRYSTAL POLYMORPHIC FORMAN FOR INHIBITING TROMBOCYTE AGGREGATION
GEP20115166B (en) 2-ARYLINDOLE DERIVATIVES AS mPGES-I INHIBITORS
DK1618113T3 (da) Hidtil ukendte krystallinske polymorfer af clopidogrel
GB0423816D0 (en) Real time optimization of well production without creating undue risk of formation instability
ATE501153T1 (de) Kristallisation von festen formen von clopidogreladditionssalzen
EA200600137A1 (ru) Способ получения аморфной формы ингибитора агрегации тромбоцитов
DE602005010369D1 (de) 2-thiaquinolizidines als Glycosidase- und Glycosyltransferase-Inhibitoren
BRPI0416678A (pt) pirazolpirimidinas
EA200601921A1 (ru) Полиморфные формы гидробромида метил-(+)-(s)-альфа-(2-хлорфенил)-6,7-дигидротиено [3,2-c] пиридин-5(4н)-ацетата, гидробромида клопидогреля
UA84335C2 (ru) Клопидогрель и его полиморфные формы
AR056805A1 (es) Un proceso para oxidacion para la preparcion de n- (3- amino-1- ( ciclobutilmetil) -2,3- dioxopropil ) -3-(n-(( ter-butilamino) carbonil )-3- metil- l- valil) -6,6- dimetil-3- azabiciclo (3.1.0) hexano -2- carboxamida y compuestos ralacionados
EA200701770A1 (ru) СПОСОБ РАЦЕМИЗАЦИИ R(-) ИЗОМЕРА МЕТИЛОВОГО ЭФИРА (2-ХЛОРФЕНИЛ)-6,7-ДИГИДРОТИЕНО[3,2-c]ПИРИДИН-5(4Н)-УКСУСНОЙ КИСЛОТЫ
AU2003235806A1 (en) Dibenzodiazepine derivates, their preparation and use
CY1112457T1 (el) Χρωμανο- και θειοxρωμανο-3-υλο-1,3-διυδρο-ιμιδαζολια ως αναστολεις της ντοπαμινο-β-υδροξυλασης, και μεθοδοι παρασκευης αυτων
DE602004030091D1 (de) Verfahren zur reduktiven deshalogenierung