US20040093646A1
(en)
*
|
1988-02-26 |
2004-05-13 |
Erwin Robert L. |
Production of lysosomal enzymes in plants by transient expression
|
US6846968B1
(en)
*
|
1988-02-26 |
2005-01-25 |
Large Scale Biology Corporation |
Production of lysosomal enzymes in plants by transient expression
|
US6660500B2
(en)
|
1988-02-26 |
2003-12-09 |
Large Scale Biology Corporation |
Production of peptides in plants as viral coat protein fusions
|
US20050032211A1
(en)
*
|
1996-09-26 |
2005-02-10 |
Metabogal Ltd. |
Cell/tissue culturing device, system and method
|
IL155588A0
(en)
*
|
2003-04-27 |
2003-11-23 |
Metabogal Ltd |
Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
|
US7361331B2
(en)
*
|
1996-10-18 |
2008-04-22 |
Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food |
Plant bioreactors
|
ES2138924B1
(es)
*
|
1998-01-23 |
2000-10-01 |
Consejo Superior Investigacion |
Promotor y secuencias reguladoras de ha ds10 g1: un gen lea de girasol expresado exclusivamente en semillas desde la fase de maduracion.
|
US6096546A
(en)
*
|
1998-01-30 |
2000-08-01 |
Board Of Trustees, Rutgers, The State University Of New Jersey |
Methods for recovering polypeptides from plants and portions thereof
|
EP1078075A2
(de)
*
|
1998-05-13 |
2001-02-28 |
Harbor-Ucla Research and Education Institute |
Rekombinante (alpha)-l-iduronidase, deren herstellungs- und aufreinigungs-verfahren, und verfahren zur behandlung von durch diese hervorgerufene mangelerkrankungen
|
WO2000000624A1
(en)
*
|
1998-06-26 |
2000-01-06 |
Croptech Development Corporation |
Production of urokinase in plant-based expression systems
|
EP1063297B1
(de)
*
|
1999-06-22 |
2008-12-17 |
Korea Kumho Petrochemical Co. Ltd. |
Farnesylpyrophosphat-Synthase (FPS) aus Setzlingen der Sonnenblume (Helianthus annus)
|
US6642038B1
(en)
|
1999-09-14 |
2003-11-04 |
Genzyme Glycobiology Research Institute, Inc. |
GlcNAc phosphotransferase of the lysosomal targeting pathway
|
US6770468B1
(en)
|
1999-09-14 |
2004-08-03 |
Genzyme Glycobiology Research Institute, Inc. |
Phosphodiester-α-GlcNAcase of the lysosomal targeting pathway
|
US6569661B1
(en)
|
1999-11-12 |
2003-05-27 |
Biomarin Pharmaceutical Inc. |
Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
|
US6585971B1
(en)
|
1999-11-12 |
2003-07-01 |
Harbor-Ucla Research And Education Institute |
Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof
|
US6426208B1
(en)
|
1999-11-12 |
2002-07-30 |
Harbor-Ucla Research And Education Institute |
Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
|
DE60138535D1
(de)
*
|
2000-02-04 |
2009-06-10 |
Children S Hospital Res Founda |
Verwendung von lysosomal acid lipase zur behandlung von atherosklerose und ähnlichen krankheiten
|
US20020061309A1
(en)
*
|
2000-03-08 |
2002-05-23 |
Garger Stephen J. |
Production of peptides in plants as N-terminal viral coat protein fusions
|
WO2001077307A2
(en)
*
|
2000-04-06 |
2001-10-18 |
Exegenics, Inc. |
Expression system for efficiently producing clinically effective lysosomal enzymes (glucocerebrosidase)
|
US7138262B1
(en)
*
|
2000-08-18 |
2006-11-21 |
Shire Human Genetic Therapies, Inc. |
High mannose proteins and methods of making high mannose proteins
|
US20030033637A1
(en)
*
|
2001-06-05 |
2003-02-13 |
Croptech Corporation |
Gene expression and production of TGF-beta proteins including bioactive mullerian inhibiting substance from plants
|
US7812227B2
(en)
|
2001-11-13 |
2010-10-12 |
U.S. Smokeless Tobacco Company |
Cloning of cytochrome p450 genes from nicotiana
|
US7700834B2
(en)
*
|
2001-11-13 |
2010-04-20 |
U.S. Smokless Tobacco Company |
Nicotiana nucleic acid molecules and uses thereof
|
US8592663B2
(en)
|
2001-11-13 |
2013-11-26 |
U.S. Smokeless Tobacco Company Llc |
Tobacco nicotine demethylase genomic clone and uses thereof
|
US20040162420A1
(en)
*
|
2002-10-16 |
2004-08-19 |
U.S. Smokeless Tobacco Company |
Cloning of cytochrome p450 genes from nicotiana
|
US20040117869A1
(en)
*
|
2002-01-11 |
2004-06-17 |
U.S. Smokeless Tobacco Company |
Cloning of cytochrome P450 genes from Nicotiana
|
US20040111759A1
(en)
*
|
2001-11-13 |
2004-06-10 |
U.S. Smokeless Tobacco Company |
Identification and use of cytochrome P450 nucleic acid sequences from tobacco
|
US7855318B2
(en)
*
|
2001-11-13 |
2010-12-21 |
U.S. Smokeless Tobacco Company |
Cloning of cytochrome P450 genes from Nicotiana
|
US10266836B2
(en)
|
2001-11-13 |
2019-04-23 |
U.S. Smokeless Tobacco Company Llc |
Tobacco nicotine demethylase genomic clone and uses thereof
|
US7700851B2
(en)
*
|
2001-11-13 |
2010-04-20 |
U.S. Smokeless Tobacco Company |
Tobacco nicotine demethylase genomic clone and uses thereof
|
US20030124652A1
(en)
*
|
2001-12-21 |
2003-07-03 |
Novazyme Pharmaceuticals, Inc. |
Methods of producing high mannose glycoproteins in complex carbohydrate deficient cells
|
US6800472B2
(en)
*
|
2001-12-21 |
2004-10-05 |
Genzyme Glycobiology Research Institute, Inc. |
Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase
|
US6905856B2
(en)
*
|
2001-12-21 |
2005-06-14 |
Genzyme Glycobiology Research Institute, Inc. |
Soluble GlcNAc phosphotransferase
|
ITRM20020115A1
(it)
*
|
2002-03-01 |
2003-09-01 |
Plantechno S R L |
Espressione di enzimi lisosomiali in seme.
|
US7329798B2
(en)
*
|
2002-06-28 |
2008-02-12 |
University Of Guelph |
Harvest-inducible regulatory elements and methods of using same
|
AU2003245772A1
(en)
|
2002-06-28 |
2004-01-19 |
University Of Guelph |
Harvest-inducible genes form alfalfa (medicago sativa) and methods of use thereof
|
JP2004140323A
(ja)
*
|
2002-08-20 |
2004-05-13 |
Sharp Corp |
半導体レーザ装置およびその製造方法
|
US6920521B2
(en)
*
|
2002-10-10 |
2005-07-19 |
International Business Machines Corporation |
Method and system of managing virtualized physical memory in a data processing system
|
US7388079B2
(en)
*
|
2002-11-27 |
2008-06-17 |
The Regents Of The University Of California |
Delivery of pharmaceutical agents via the human insulin receptor
|
AU2007201909C1
(en)
*
|
2003-04-27 |
2011-12-01 |
Protalix Ltd. |
Production of High Mannose Proteins in Plant Culture
|
US7951557B2
(en)
*
|
2003-04-27 |
2011-05-31 |
Protalix Ltd. |
Human lysosomal proteins from plant cell culture
|
US20100196345A1
(en)
*
|
2003-04-27 |
2010-08-05 |
Protalix |
Production of high mannose proteins in plant culture
|
US7442372B2
(en)
|
2003-08-29 |
2008-10-28 |
Biomarin Pharmaceutical Inc. |
Delivery of therapeutic compounds to the brain and other tissues
|
US8637731B2
(en)
*
|
2003-10-16 |
2014-01-28 |
U.S. Smokeless Tobacco Company |
Nicotiana nucleic acid molecules and uses thereof
|
CN1926235B
(zh)
|
2003-10-16 |
2012-07-18 |
美国无烟烟草有限责任公司 |
从烟草克隆细胞色素p450基因
|
EP1691822A4
(de)
*
|
2003-12-09 |
2008-01-02 |
Ventria Bioscience |
Hochexpression von fusionspolypeptiden in pflanzensamen mit samenaufbewahrungsproteinen als fusionsträger
|
US8586837B2
(en)
*
|
2004-04-29 |
2013-11-19 |
U.S. Smokeless Tobacco Company Llc |
Nicotiana nucleic acid molecules and uses thereof
|
US20080034455A1
(en)
*
|
2004-05-21 |
2008-02-07 |
Simon Fraser University |
Production Of A Protein Localized To The Endoplasmic Reticulum Protein Bodies In A Transgenic Plant And Seed
|
DE102004043207C5
(de)
*
|
2004-09-03 |
2010-09-09 |
Südzucker AG Mannheim/Ochsenfurt |
Wurzel- und xylemparenchymspezifischer Promotor
|
BRPI0519985B1
(pt)
|
2005-02-23 |
2018-01-30 |
University Of Kentucky Research Foundation |
Método para redução do nível de nornicotina ou n-nitrosonornicotina em uma planta do gênero nicotiana ou parte desta ou em um produto de tabaco, cassete de expressão e método para a produção de uma planta do gênero nicotiana
|
CA2607678C
(en)
*
|
2005-05-09 |
2015-07-14 |
Simon Fraser University |
Production of animal proteins in n-glucosaminyltransferase i-deficient plants
|
AU2006271181B2
(en)
*
|
2005-07-18 |
2012-07-12 |
Protalix Ltd. |
Mucosal or enteral administration of biologically active macromolecules
|
WO2007030375A2
(en)
*
|
2005-09-08 |
2007-03-15 |
Children's Hospital Medical Center |
Lysosomal acid lipase therapy for nafld and related diseases
|
ES2391657T3
(es)
|
2006-02-07 |
2012-11-28 |
Shire Human Genetic Therapies, Inc. |
Composiciones estabilizadas de proteínas que tienen un resto tiol libre
|
US7871624B2
(en)
*
|
2006-06-27 |
2011-01-18 |
Saint Louis University |
Chimeral polypeptide composition for cross-placenta delivery
|
US8784833B2
(en)
|
2006-06-27 |
2014-07-22 |
Saint Louis University |
Prenatal enzyme replacement therapy for hypophosphatasia
|
US11332753B2
(en)
|
2006-12-15 |
2022-05-17 |
U.S. Smokeless Tobacco Company Llc |
Tobacco plants having reduced nicotine demethylase activity
|
US8319011B2
(en)
|
2006-12-15 |
2012-11-27 |
U.S. Smokeless Tobacco Company Llc |
Tobacco plants having reduced nicotine demethylase activity
|
BRPI0810343B1
(pt)
|
2007-05-07 |
2021-03-30 |
Protalix Ltd |
Dispositivo descartável para o cultivo e colheita de tecidos vegetais e/ou células, método de cultivo e colheita de um tecido vegetal e/ou células vegetais em um volume maior do que 400 litros e sistema de cultivo da célula vegetal
|
BRPI0815324A2
(pt)
|
2007-08-20 |
2015-07-14 |
Protalix Ltd |
"conjugado protêico que contém sacarídeos, processo de separação do conjugado protêico que contém sacarídeos, composição farmacêutica do conjugado protêico que contém sacarídeos, uso do conjugado protêico que contém sacarídeos e composto do conjugado protêico que contém sacarídeos"
|
EP2220231B1
(de)
|
2007-11-12 |
2017-10-11 |
North Carolina State University |
Änderung des tabakalkaloidgehalts durch modifizierung spezifischer cytochrom-p450-gene
|
ITUD20080055A1
(it)
|
2008-03-13 |
2009-09-14 |
Transactiva S R L |
Procedimento per la produzione di una proteina umana in pianta, in particolare un enzima lisosomiale umano ricombinante in endosperma di cereali
|
CN105126086B
(zh)
|
2009-07-28 |
2019-05-14 |
夏尔人类遗传性治疗公司 |
用于治疗戈谢病的组合物和方法
|
EP2470199B1
(de)
|
2009-08-28 |
2019-05-22 |
Icahn School of Medicine at Mount Sinai |
Dosiserhöhungs- und enzymersatztherapie zur behandlung mangelnder saurer sphingomyelinase
|
US9194011B2
(en)
|
2009-11-17 |
2015-11-24 |
Protalix Ltd. |
Stabilized alpha-galactosidase and uses thereof
|
CN102858983B
(zh)
|
2010-01-15 |
2015-08-12 |
北卡罗来纳州立大学 |
最小化烟草中去甲烟碱合成的组合物和方法
|
ES2950358T3
(es)
|
2010-04-23 |
2023-10-09 |
Alexion Pharma Inc |
Enzima de la enfermedad de almacenamiento lisosomal
|
WO2012012461A2
(en)
|
2010-07-19 |
2012-01-26 |
Shire Human Genetic Therapies, Inc. |
Mannose receptor c type 1 (mrc1) codon optimized cell line and uses thereof
|
EP3650039A1
(de)
|
2010-09-09 |
2020-05-13 |
Alexion Pharmaceuticals, Inc. |
Verwendung von lysosomaler saurer lipase zur behandlung von patienten mit mangel an lyosomaler saurer lipase
|
LT3272861T
(lt)
|
2011-01-20 |
2020-03-25 |
Protalix Ltd. |
Alfa-galaktozidazės kompozicijos
|
WO2012112681A1
(en)
|
2011-02-15 |
2012-08-23 |
Shire Human Genetic Therapies, Inc. |
Methods for treating lysosomal acid lipase deficiency
|
WO2012118779A1
(en)
|
2011-02-28 |
2012-09-07 |
North Carolina State University |
Tobacco inbred plants ncbex1f, ncbex1ms, and nc ex90
|
CN103562393A
(zh)
|
2011-02-28 |
2014-02-05 |
奥驰亚客户服务公司 |
烟草近交植物albex1f和albex1ms
|
TWI620816B
(zh)
*
|
2011-03-23 |
2018-04-11 |
苜蓿股份有限公司 |
植物衍生蛋白回收方法
|
WO2012170678A1
(en)
*
|
2011-06-07 |
2012-12-13 |
Fraunhofer Usa, Inc. |
In vivo de-glycosylation of recombinant proteins by co-expression with pngase f
|
US20140161896A1
(en)
*
|
2011-08-04 |
2014-06-12 |
Ramot At Tel-Aviv University Ltd. |
Particles for the treatment of neurodegenerative diseases
|
IN2014CN02114A
(de)
|
2011-09-20 |
2015-05-29 |
Sinai School Medicine |
|
KR20140138850A
(ko)
|
2012-03-02 |
2014-12-04 |
샤이어 휴먼 지네틱 테라피즈 인크. |
Iii형 고셔병을 치료하기 위한 조성물 및 방법
|
EP2854834A4
(de)
|
2012-05-30 |
2016-05-18 |
Biostrategies LC |
Pflanzenlektine als träger entsprechender wirkstoffe in tierischen und menschlichen zellen
|
EP4154907A1
(de)
|
2012-12-18 |
2023-03-29 |
Icahn School of Medicine at Mount Sinai |
Influenzavirusimpfstoffe und verwendungen davon
|
US9603335B2
(en)
|
2013-01-11 |
2017-03-28 |
North Carolina State University |
Tobacco inbred plants K326 SRC, CMS K326 SRC, K346 SRC, CMS K346 SRC, NC1562-1 SRC, NCTG-61 SRC, CMS NCTG-61 SRC and hybrid NC196 SRC
|
WO2014137802A1
(en)
|
2013-03-05 |
2014-09-12 |
North Carolina State University |
Tobacco inbred and hybrid plants and uses thereof
|
US9908930B2
(en)
|
2013-03-14 |
2018-03-06 |
Icahn School Of Medicine At Mount Sinai |
Antibodies against influenza virus hemagglutinin and uses thereof
|
EP3113603A1
(de)
|
2014-03-03 |
2017-01-11 |
North Carolina State University |
Inzucht- und hybridtabakpflanzen und daraus hergestellte tabakprodukte
|
EP3113602A1
(de)
|
2014-03-03 |
2017-01-11 |
North Carolina State University |
Inzucht- und hybridtabakpflanzen und daraus hergestellte tabakprodukte
|
WO2015134427A1
(en)
|
2014-03-03 |
2015-09-11 |
North Carolina State University |
Tobacco inbred and hybrid plants and tobacco products made thereof
|
EP3912635A1
(de)
*
|
2014-07-11 |
2021-11-24 |
Biostrategies LC |
Materialien und verfahren zur behandlung von leiden in zusammenhang mit sulfataseenzymen
|
AP2017009676A0
(en)
*
|
2014-07-18 |
2017-01-31 |
Philip Morris Products Sa |
Tobacco protease genes
|
WO2016118937A1
(en)
|
2015-01-23 |
2016-07-28 |
Icahn School Of Medicine At Mount Sinai |
Influenza virus vaccination regimens
|
CN109641041A
(zh)
|
2016-06-15 |
2019-04-16 |
西奈山伊坎医学院 |
流感病毒血细胞凝集素蛋白及其用途
|
CA3058652A1
(en)
|
2017-04-07 |
2018-10-11 |
Icahn School Of Medicine At Mount Sinai |
Anti-influenza b virus neuraminidase antibodies and uses thereof
|