CN211066593U - Multi-brain-area recording electrode - Google Patents
Multi-brain-area recording electrode Download PDFInfo
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- CN211066593U CN211066593U CN201921409246.9U CN201921409246U CN211066593U CN 211066593 U CN211066593 U CN 211066593U CN 201921409246 U CN201921409246 U CN 201921409246U CN 211066593 U CN211066593 U CN 211066593U
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Abstract
The utility model discloses a many brain district recording electrode relates to medical equipment technical field. This many brain district record electrode is including arranging needle and a plurality of single brain district electrode of mutual parallel connection, and a plurality of single brain district electrodes have the link and the implantation end of relative setting respectively, and the link of a plurality of single brain district electrodes is connected with row needle electricity respectively, and a plurality of single brain district electrodes all extend along same direction, and the implantation end of two arbitrary single brain district electrodes sets up at the interval on the extending direction of single brain district electrode, a plurality of single brain district electrodes implantation end is used for inserting respectively to different target brain districts. The utility model provides a many brain district recording electrode can implant simultaneously to a plurality of target brain districts, convenient and fast, save time and human cost, and extensive applicability.
Description
Technical Field
The utility model relates to the technical field of medical equipment, particularly, relate to a many brain district recording electrode.
Background
The action potentials and the local field potentials of a plurality of brain areas of the brain of the test animal are synchronously recorded through the brain area recording electrodes, so that the problem of recording the electrical activity functions of the plurality of brain areas on the freely moving animal under a specific ethology paradigm is solved, the related loop functions under the ethology are analyzed, and the neural loop function analysis is facilitated.
At present, single brain area electrodes on the market are used for signal recording of a single brain area, when signal recording of multiple brain areas is carried out, a plurality of single brain area electrodes need to be implanted respectively and sequentially aiming at different target brain areas, more time and larger cost are consumed in the process, in addition, a plurality of single brain area electrodes need to be implanted into different positions, and the implantation cannot be carried out when the brain volume of an implanted object is smaller.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a many brain district recording electrode, it can once only implant to a plurality of different target brain districts.
The utility model provides a technical scheme:
the utility model provides a many brains district record electrode, is including arranging needle and a plurality of mutual parallel connection's single brain district electrode, and is a plurality of single brain district electrode has the link and the implantation end of relative setting respectively, and is a plurality of single brain district electrode the link respectively with arrange the needle electricity and connect, it is a plurality of single brain district electrode all extends along same direction, arbitrary two implantation end of single brain district electrode is in interval setting, a plurality of in the extending direction of single brain district electrode implantation end is used for inserting respectively to different target brain districts.
Further, a plurality of the single brain region electrodes are sequentially stacked.
Furthermore, the multiple brain region recording electrode further comprises a glue layer, and any two adjacent single brain region electrodes are connected through the glue layer.
Furthermore, the single brain region electrode comprises a plurality of electrode units, the electrode units are arranged in a row, and the electrode units extend along the same direction.
Further, a plurality of the electrode units are connected in sequence in the arrangement direction.
Further, the electrode unit includes sleeve pipe and wire electrode, the sleeve pipe cover is located on the wire electrode, the link with implant the end set up respectively in relative both ends on the wire electrode, implant the end and wear out the sleeve pipe, adjacent two the sleeve pipe of electrode unit is arranged and connects gradually in a row form, the sleeve pipe is used for guiding the wire electrode, so that implant the end insert to target brain district.
Further, the implanted ends of the electrode wires in the same single brain region electrode are flush.
Further, the connecting ends of the plurality of single brain region electrodes are flush.
Compared with the prior art, the utility model provides a many brains district recording electrode, a plurality of single brains district mutual parallel connection, and all extend along same direction, and the end of implanting into of two arbitrary single brains district electrodes sets up at the interval on the extending direction of single brains district electrode. In practical application, a plurality of single brain region electrodes which are connected together are implanted simultaneously until the implantation end of each single brain region electrode reaches the corresponding target brain region, implantation can be completed, and the implantation device is convenient and rapid to use, occupies a small space, and is not influenced by the brain volume of an implanted object. Therefore, the utility model provides a many brain district recording electrode's beneficial effect is: can implant to a plurality of target brain areas simultaneously, convenient and fast, save time and human cost, and extensive applicability.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required to be used in the embodiments will be briefly described below. It is appreciated that the following drawings depict only certain embodiments of the invention and are therefore not to be considered limiting of its scope. For a person skilled in the art, it is possible to derive other relevant figures from these figures without inventive effort.
Fig. 1 is a schematic structural diagram of a multi-brain region recording electrode according to an embodiment of the present invention;
FIG. 2 is a schematic view of the pin header of FIG. 1;
FIG. 3 is a schematic diagram of the structure of the single brain region electrode of FIG. 1;
fig. 4 is a schematic block diagram of a flow chart of a method for manufacturing a multi-brain-region recording electrode according to an embodiment of the present invention;
fig. 5 is a schematic block diagram illustrating a flow chart of a method for implanting a multi-brain region recording electrode according to an embodiment of the present invention.
Icon: 100-multiple brain region recording electrodes; 110-row needles; 111-a body portion; 113-stitch; 130-single brain region electrodes; 131-a connection end; 132-an electrode unit; 1321-cannula; 1323-wire electrode; 133-an implanted end; 150-glue line.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the drawings in the embodiments of the present invention are combined below to clearly and completely describe the technical solutions in the embodiments of the present invention. It is to be understood that the embodiments described are only some of the embodiments of the present invention, and not all of them. The components of embodiments of the present invention, as generally described and illustrated in the figures herein, may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, presented in the accompanying drawings, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the present invention, it should be understood that the relation indicating the direction or position such as "up" is based on the direction or position shown in the drawings, or the direction or position conventionally placed when the utility model is used, or the direction or position conventionally understood by those skilled in the art, and is only for convenience of description and simplification of the description, and it does not indicate or imply that the indicated device or element must have a specific direction, be constructed and operated in a specific direction, and thus, should not be construed as limiting the present invention.
Furthermore, the terms "first," "second," and the like are used merely to distinguish one description from another, and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be further noted that, unless explicitly stated or limited otherwise, the terms "disposed" and "connected" are to be interpreted broadly, and for example, "connected" may be a fixed connection, a detachable connection, or an integral connection; can be mechanically or electrically connected; the connection may be direct or indirect via an intermediate medium, and may be a communication between the two elements. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art.
The following describes in detail embodiments of the present invention with reference to the accompanying drawings.
Referring to fig. 1, a multi-brain region recording electrode 100 according to an embodiment of the present invention is used for implanting into a brain of an experimental animal to synchronously record action potentials and local field potentials of a plurality of brain regions, thereby solving a problem of recording activity functions of a plurality of brain regions on a freely moving animal in a specific ethological paradigm, and analyzing related loop functions in the ethological. The multi-brain-region recording electrode 100 provided by the embodiment can be implanted into a plurality of target brain regions at the same time, is convenient and fast, saves time and labor cost, and has wide applicability.
The multi-brain-region recording electrode 100 provided by this embodiment includes a needle bar 110 and a plurality of single brain region electrodes 130 connected in parallel, wherein the plurality of single brain region electrodes 130 are respectively inserted into different target brain regions, the plurality of single brain region electrodes 130 respectively have a connecting end 131 and an implanted end 133 that are oppositely disposed, the connecting ends 131 of the plurality of single brain region electrodes 130 are respectively electrically connected with the needle bar 110, and the implanted ends 133 of the plurality of single brain region electrodes 130 are used for being inserted into corresponding target brain regions. The plurality of single brain region electrodes 130 all extend along the same direction, that is, the plurality of single brain region electrodes 130 in the multi-brain region recording electrode 100 provided by this embodiment are all arranged in parallel, and in an actual implantation process, the implantation direction angles of the plurality of single brain region electrodes 130 are also the same. The implanted ends 133 of any two single-brain-region electrodes 130 are spaced apart in the extending direction of the single-brain-region electrodes 130, that is, the implanted end 133 of one single-brain-region electrode 130 in any two single-brain-region electrodes 130 passes over the implanted end 133 of the other single-brain-region electrode 130 in the extending direction of the single-brain-region electrode 130.
Referring to fig. 1 and 2, the pin header 110 can be connected to the electrophysiology recording apparatus. The pin header 110 includes a main body 111 and a plurality of rows of pins 113 protruding from one side of the main body 111, and the specific number and the number of the distributed layers of the pins 113 are determined according to the specific number of the single brain region electrodes 130. In this embodiment, the pin header 110 with 16 channels is adopted, that is, the number of the pins 113 is 16, and the pin header is distributed in two layers, each layer is 8, so that the two single brain region electrodes 130 are correspondingly connected, that is, the two single brain regions are correspondingly inserted.
In the actual manufacturing process, the matched pin header 110 is selected according to the number of the target brain areas, and then the corresponding single brain area electrode 130 is manufactured. For example, when the brain area corresponds to three brain areas, the pin array 110 with three rows of pins 113 is selected, and each row of pins 113 is correspondingly connected with one single brain area electrode 130. When the experimental multiple brain area is a four brain area, the 32-channel pin header 110 can be directly adopted, the pins 113 on the pin header are arranged in 4 layers, each layer is 8, the pins 113 on each layer are correspondingly connected with one single brain area electrode 130, and the 4 single brain area electrodes 130 are sequentially stacked and connected.
In the actual implantation process of the multi-brain region recording electrode 100 provided in this embodiment, since the implantation ends 133 of the plurality of single-brain region electrodes 130 are disposed at intervals in the extending direction of the single-brain region electrodes 130, the implantation ends 133 of the plurality of single-brain region electrodes 130 can stay in different brain regions of the brain of the experimental animal when the external force effect of implantation is stopped. In practical application, the multi-brain-region recording electrode 100 is selected according to different brain regions of the brain of the experimental animal, when the multi-brain-region recording electrode 100 is implanted under the action of external force, the plurality of single-brain-region electrodes 130 simultaneously move towards the respective corresponding target brain regions along the implantation direction, and stop until the implantation ends 133 of the single-brain-region electrodes 130 reach the respective corresponding target brain regions, so that the implantation of the multi-brain-region recording electrode 100 is completed, and the plurality of single-brain-region electrodes 130 are simultaneously implanted into the respective corresponding target brain regions, so that the action potentials and the local field potentials of the plurality of brain regions can be synchronously recorded.
In this embodiment, the single brain region electrodes 130 are sequentially stacked, and in other embodiments, the single brain regions 130 may be spaced side by side according to the implantation requirement, and the single brain regions 130 are connected together through other intermediate members. In addition, the plurality of single brain regions 130 may also lie in a plurality of different planes and the planes in which they lie intersect.
The multi-brain region recording electrode 100 further comprises a glue layer 150, and any two adjacent single-brain region electrodes 130 are connected through the glue layer 150. In the actual manufacturing process of the multi-brain region recording electrode 100 provided in this embodiment, two adjacent single-brain region electrodes 130 are bonded by a bonding agent such as glue, so that the multiple single-brain region electrodes 130 are sequentially stacked, and the bonding agent is solidified to form the adhesive layer 150. In other embodiments, the two adjacent single brain region electrodes 130 may be connected by other forms, such as binding by a binding member.
As shown in fig. 1 and fig. 3, the single brain region electrode 130 includes a plurality of electrode units 132, the electrode units 132 are arranged in rows, and the electrode units 132 all extend along the same direction, i.e., the electrode units 132 are parallel to each other.
In this embodiment, the plurality of electrode units 132 are sequentially connected in the arrangement direction, and two adjacent electrode units 132 are directly and sequentially bonded by a bonding agent such as glue. In other embodiments, the plurality of electrode units 132 on the same single brain region electrode 130 can be connected and fixed together by other forms, such as binding by a binding member.
The electrode unit 132 includes a sleeve 1321 and a wire 1323, the sleeve 1321 is sleeved on the wire 1323, the connection end 131 and the implantation end 133 are respectively disposed at two opposite ends of the wire 1323, and the implantation end 133 penetrates through the sleeve 1321. In the actual manufacturing process, since the wire used for the wire electrode 1323 is often soft and is difficult to be inserted into the corresponding target brain region in the implantation process, the sleeve 1321 is sleeved on the wire electrode 1323 for guiding the wire electrode 1323, so that the implantation end 133 is inserted into the target brain region. In this embodiment, the sleeve 1321 is a silicon tube, and in other embodiments, the sleeve 1321 may also be a tube made of other materials according to actual implantation requirements.
As shown in fig. 1, the multi-brain recording electrode 100 of the present embodiment has 16 channels, and the wire 1323 of each sleeve 1321 is formed by twisting two wires together, that is, each wire 1323 has two channels, that is, the number of the sleeves 1321 is 8. A layer of 4 sleeves 1321 is sleeved on the 4 electrode wires 1323 to form 4 electrode units 132, and the 4 electrode units 132 are arranged to form a single brain region electrode 130. Another layer of 4 sleeves 1321 is sleeved on the other 4 electrode wires 1323 to form 4 electrode units 132, and the 4 electrode units 132 are arranged to form another single brain region electrode 130. The two single brain area electrodes 130 are arranged in a stacked mode, a row needle 110 with 16 channels is selected correspondingly, 16 pins 113 are correspondingly arranged on the row needle 110, the 16 pins 113 are also arranged in two rows, and two metal wires in 4 electrode wires 1323 in one single brain area electrode 130 are welded with 8 pins 113 in one row in a one-to-one correspondence mode. In other embodiments, the wire electrode 1323 may be electrically connected to the pin 113 of the pin header 110 through other forms, such as a wire connection.
In other embodiments, the number of channels, such as 32 channels, may be changed according to other experimental requirements, such as the actual number of the actual target brain areas, and the corresponding pins 110 may be selected.
In this example. The implanted ends 133 of the multiple wire electrodes 1323 in the same single cerebrum area electrode 130 are flush. In other embodiments, the implanted ends 133 of the multiple wires 1323 of the same single brain region electrode 130 may have some tolerance, i.e., be substantially flush, to account for practical manufacturing uncertainties. In addition, in this embodiment, the connection ends 131 of the multiple electrode wires 1323 in the same single brain region electrode 130 are also flush.
When the multi-brain-region recording electrode 100 is implanted under an external force, the plurality of single-brain-region electrodes 130 simultaneously move toward the respective corresponding target brain regions along the implantation direction and stop until the implantation ends 133 of the single-brain-region electrodes 130 reach the respective corresponding target brain regions, that is, the implantation of the multi-brain-region recording electrode 100 is completed, and the plurality of single-brain-region electrodes 130 are simultaneously implanted into the respective corresponding target brain regions, so that the action potentials and the local field potentials of the plurality of brain regions can be synchronously recorded. Therefore, the multi-brain-region signal recording electrode pattern and the corresponding electrode implantation method are simplified, and under the condition that the brain volume of an implantation object is smaller, because the electrodes in the single brain regions are not implanted in a partitioning mode, the implantation space occupied on the surface of the brain is extremely small, the implementation range is larger, and the applicability is wide.
Therefore, the utility model provides a many brain district record electrode simple structure can implant simultaneously to a plurality of target brain districts, convenient and fast, save time and human cost, and extensive applicability.
The utility model provides a structural style that many brain district record electrode 100 provided to not be limited to the record of many brain district signal, also can implant optic fibre in some brain district and carry out the light stimulation.
Referring to fig. 4, the present invention further provides a method for manufacturing a multi-brain-region recording electrode, for manufacturing the multi-brain-region recording electrode 100 according to the embodiment, including:
step S101, measuring the distance between a plurality of target brain areas to obtain a plurality of preset distance values.
The predetermined distance value is a distance between the implanted ends 133 of any two single-brain-region electrodes 130 in the extending direction of the single-brain-region electrodes 130.
Further, the method for manufacturing the multi-brain region recording electrode further comprises the following steps:
step S102 is to connect the plurality of single brain region electrodes 130 in parallel, and to align the extending directions of the plurality of single brain region electrodes 130.
In this embodiment, one end of the electrode wire 1323 passes through the sleeve 1321 to form one electrode unit 132, and then the plurality of electrode units 132 are arranged in rows and connected in sequence to form the single brain region electrode 130. The extension direction of the single brain region electrode 130 is the extension direction of the cannula 1321.
Further, the method for manufacturing the multi-brain region recording electrode further comprises the following steps:
step S103, cutting the plurality of single brain region electrodes 130 to obtain the implanted ends 133 and the connection ends 131, and setting the implanted ends 133 of any two single brain region electrodes 130 at a preset distance value in the extending direction of the single brain region electrodes 130.
Cutting one ends of the multiple electrode wires 1323, which penetrate out of the sleeve 1321, according to the multiple preset distance values obtained in step S101, so that the interval between the electrode wires 1323 on any two single-brain-region electrodes 130 in the extending direction of the sleeve 1321 is equal to the preset distance value. One end of the cut wire electrode 1323 is the implanting end 133, and the other end opposite to the implanting end 133 is the connecting end 131.
Further, the method for manufacturing the multi-brain region recording electrode further comprises the following steps:
step S104 is to electrically connect the connection terminals 131 of the plurality of single brain region electrodes 130 to the pin header 110, respectively.
After the multi-brain recording electrode 100 is manufactured, it needs to be modified and detected. Through the utility model provides a method for making many brain areas recording electrode can make and obtain like the many brain areas electrode 100 that the embodiment provided.
Referring to fig. 5, the present invention further provides an implanting method of a multi-brain-region recording electrode, which uses the multi-brain-region recording electrode 100 provided in the embodiment, and the implanting method of the multi-brain-region recording electrode includes:
step S201, a plurality of target brain regions are located.
Positioning a plurality of target brain areas in the brain of the experimental object by means of animal brain area positioning operation and the like, and determining the implantation direction.
Further, the implantation method of the multi-brain region recording electrode further comprises the following steps:
step S202, the multi-brain region recording electrode 100 is pushed, so that the implantation ends 133 of the single brain region electrodes 130 are simultaneously inserted into the corresponding target brain regions.
Implanting the multi-brain-region recording electrode 100 according to the implantation direction determined in step S201, wherein in the implantation process, the plurality of single-brain-region electrodes 130 on the multi-brain-region recording electrode 100 all move toward the respective corresponding target brain region, and when each single-brain-region electrode 130 reaches the respective corresponding target brain region, stopping pushing, and fixing the multi-brain-region recording electrode 100 by dental cement or other fixing methods.
Further, the implantation method of the multi-brain region recording electrode further comprises the following steps:
in step S203, the multi-brain region recording electrode 100 is fixed to the skull bone.
The multi-brain region recording electrode 100 is fixed on the corresponding skull of the brain of the implantation object, and the implantation is completed.
The utility model provides an implantation method of polyencephalon district recording electrode for implant experimental brain with polyencephalon district recording electrode 100 like the embodiment provides, and in the in-service use, this implantation method of polyencephalon district recording electrode and polyencephalon district recording electrode 100 that the embodiment provided do not necessarily need to bind together completely.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. The utility model provides a many brain district record electrode, its characterized in that, is including arranging needle and a plurality of mutual parallel connection's single brain district electrode, and is a plurality of single brain district electrode has the link and the implantation end of relative setting respectively, and is a plurality of single brain district electrode the link respectively with it is connected to arrange the needle electricity, and is a plurality of single brain district electrode all extends along same direction, arbitrary two implantation end of single brain district electrode is in interval setting in the extending direction of single brain district electrode, it is a plurality of single brain district electrode the implantation end is used for inserting respectively to different target brain districts.
2. The multi-brain region recording electrode according to claim 1, wherein a plurality of the single-brain region electrodes are sequentially stacked.
3. The multibrain region recording electrode according to claim 1, further comprising a glue layer, wherein any two adjacent single brain region electrodes are connected by the glue layer.
4. The multi-brain-region recording electrode according to claim 1, wherein the single-brain-region electrode comprises a plurality of electrode units, the plurality of electrode units are arranged in a row, and the plurality of electrode units extend along the same direction.
5. The multi-brain-region recording electrode according to claim 4, wherein a plurality of the electrode units are connected in series in the arrangement direction.
6. The multi-brain-region recording electrode according to claim 4, wherein the electrode unit comprises a sleeve and a wire electrode, the sleeve is sleeved on the wire electrode, the connecting end and the implanting end are respectively arranged at two opposite ends of the wire electrode, the implanting end penetrates out of the sleeve, the sleeves of two adjacent electrode units are arranged in a row and sequentially connected, and the sleeve is used for guiding the wire electrode so that the implanting end is inserted into the target brain region.
7. The polybrain recording electrode of claim 6, wherein said implanted ends of said plurality of wires in the same single brain region electrode are flush.
8. The multibrain region recording electrode according to claim 1, wherein the connecting ends of a plurality of the single brain region electrodes are flush.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201921409246.9U CN211066593U (en) | 2019-08-27 | 2019-08-27 | Multi-brain-area recording electrode |
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| CN201921409246.9U CN211066593U (en) | 2019-08-27 | 2019-08-27 | Multi-brain-area recording electrode |
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| CN211066593U true CN211066593U (en) | 2020-07-24 |
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