CN209172280U - Multi-modality imaging system - Google Patents
Multi-modality imaging system Download PDFInfo
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- CN209172280U CN209172280U CN201721812517.6U CN201721812517U CN209172280U CN 209172280 U CN209172280 U CN 209172280U CN 201721812517 U CN201721812517 U CN 201721812517U CN 209172280 U CN209172280 U CN 209172280U
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Abstract
The utility model is suitable for Medical Imaging Technology field, disclose multi-modality imaging system, it includes display, multi-modality imaging equipment and the host being electrically connected between display and multi-modality imaging equipment, image reconstruction and processing subsystem are equipped in host, animal scan control subsystem is equipped in multi-modality imaging equipment, stationary computers tomographic imaging subsystem and photoacoustic imaging subsystem, stationary computers tomographic imaging subsystem includes electronic control circuit, for generating the multiple beam carbon nanometer X source array of X-ray needed for stationary computers tomographic imaging scans, for the photon counting detector of computer tomography projection data acquisitions and high speed processing and for the power supply for multiple beam carbon nanometer X source powering arrays, multiple beam carbon nanometer X source array, photon counting detector and power supply are all electric with electronic control circuit Property connection.The multi-modality imaging system of the utility model, image resolution ratio is high, and imaging depth is big, and dose of radiation is low.
Description
Technical field
The utility model relates to Medical Imaging Technology field more particularly to multi-modality imaging systems.
Background technique
Cancer is most common one kind in malignant tumour, is the number one killer for threatening human health.Currently, global cancer
Swift and violent growing trend is presented in case, and new cases are mainly from developing country.Since high mortality, high disability rate and medical treatment are negative
It carries on a shoulder pole the features such as big, malignant tumour has become the public health problem or even social concern that one must pay much attention in the whole world.
In patient's lethal factor caused by cancer, metastases are most important factors.
Currently, the research to metastases mainly carries out with the toy using mouse, rat as representative.Specifically grinding
When studying carefully, tumor disease model is established with toy first, the physio-pathological characteristic of its metastases is then studied, grinds
The cancer diagnosis technology of sending out new, anti-tumor drug and therapeutic evaluation is carried out to drug.It is small in the method for various research toys
Animal whole body bioluminescence imaging technology can carry out the whole body of different time points to same a collection of toy, observe for a long time, substantially drop
Low experimental cost, and the reliable experimental data of repetition is obtained, while being in metastases early stage by highly sensitive molecular probe
It can effectively be observed, to realize the entire transfer process monitored over time to tumour cell.Related major imaging techniques
Including computer tomography (Computed Tomography, CT), magnetic resonance imaging (Magnetic Resonance
Imaging, MRI) and structure imagings and the photoacoustic imaging (Photoacoustic such as ultrasonic imaging (Ultrasound)
Imaging), positron emission tomography (Positron Emission Tomography, PET) and single photon emission calculate
The functional imagings such as machine tomographic imaging (Single Photon Emission Computed Tomography, SPECT).However,
Information acquired in these single mode imaging techniques has some limitations, and can not reflect that the complexity of organism is special completely
Property, cause the research for metastases that cannot provide comprehensive and accurate information.
In view of the deficiency of above-mentioned single mode imaging technique, the prior art proposes the multi-modal of integrated structure and functional information
Image technology, and multi-modal image technology is just being increasingly used in toy whole body living imaging, for example, using PET and
The multi-modality imaging technology that CT is combined has become the clinical reference standard of multimode molecular image, in prediction neoadjuvant
Value has been illustrated with the curative effect aspect of new targeted therapy, has been used to the metastases of detection early stage recently；For another example use
It is raw that the multi-modality imaging technology that optical imagery and PET are combined has been used to the lymphatic vessel caused during detection metastases
At.
However, in the prior art, there is also certain deficiencies for toy whole body living body multi-modality imaging technology.For example,
In PET-CT imaging, the accuracy and resolution ratio of PET can be improved by the high-energy photon attenuation coefficient figure obtained in the CT image；
But compared with PET or SPECT, near-infrared photon is easier the shadow by the tissue absorption coefficient of light relative to high-energy photon
It rings, therefore utilizes the available better imaging effect of correction for attenuation concept in optical imagery.In addition, in cancer treatment,
Since the spatial resolution of PET/SPECT is too low, it is difficult accurately to describe the targeting of drug and aggregation situation, it is whole in order to obtain simultaneously
The drug metabolism situation of body and part often carries out the assessment of drug using the bimodulus probe that can respond light modality and divides
Analysis.But optical image technology can be caused imaging depth often to only have 1 millimeter or so, be made due to the strong scattering process of organism
It is limited at application.In addition, can provide high resolution structure imaging mode in, CT be imaged on display anatomical structure, form and
Density etc. has advantage, and image taking speed is fast, can also by injection contrast agent, using spectral imaging or phase contrast imaging
Enhance soft tissue contrast, but excessive X-ray radiation can change toy physiological structure and influence to turn cancer development
Move past journey and pharmaceutically-active correct judgement.When application bioluminescence imaging technology carries out long-term longitudinal research to toy, also must
The dose of radiation that must guarantee that toy is subject to is as low as possible, to mitigate its physiological effect to toy.It can be seen that existing
Still generally existing image resolution ratio is low in a particular application, imaging depth is small for small animal living body whole body multi-modality imaging technology, radiation
The big problem of dosage.
Utility model content
The purpose of this utility model is to provide a kind of multi-modality imaging systems, aim to solve the problem that existing small animal living body whole body
There is the technical problem that image resolution ratio is low, imaging depth is small, dose of radiation is big in a particular application in multi-modality imaging technology.
In order to achieve the above objectives, scheme provided by the utility model is: multi-modality imaging system, including display, multimode at
As equipment and the host being electrically connected between the display and the multi-modality imaging equipment, image weight is equipped in the host
It builds and processing subsystem, the multi-modality imaging equipment is interior equipped with animal scan control subsystem, stationary computers tomographic imaging
System and photoacoustic imaging subsystem, the stationary computers tomographic imaging subsystem includes electronic control circuit, quiet for generating
The multiple beam carbon nanometer X source array of X-ray needed for state computer tomography scans projects number for computer tomography
According to acquisition with the photon counting detector of high speed processing and for the power supply electricity for the multiple beam carbon nanometer X source powering arrays
Source, the multiple beam carbon nanometer X source array, the photon counting detector and the power supply all with the electronic control
Circuit is electrically connected.
Optionally, the multiple beam carbon nanometer X source array includes the carbon nanometer X source of multiple array distributions, the carbon
Nanometer X source includes vacuum cavity, carbon nanometer field-transmitting cathode, grid, focusing electrode and anode, the carbon nanometer Flied emission yin
Pole, the grid, the focusing electrode and the anode are all set in the vacuum cavity, and the anode interval inclination is set to described
The top of carbon nanometer field-transmitting cathode, the grid and the focusing electrode are all set to the carbon nanometer field-transmitting cathode and the sun
Between pole, and the grid, between the focusing electrode and the carbon nanometer field-transmitting cathode, the vacuum cavity is equipped with position
In the X-ray exit window of the anode side.
Optionally, the carbon nanometer field-transmitting cathode includes substrate and the cold-cathode material set on the substrate surface
Layer.
Optionally, the substrate is metal substrate or the silicon wafer coated with metal coating；And/or
The material of the cold-cathode material layer is the mixture of carbon nanotube or graphene and carbon nanotube and graphene.
Optionally, the quantity of the carbon nanometer X source is 90-180；And/or
Each carbon nanometer X source is distributed in circular array or Polygonal arrays distribution；And/or
The X-ray exit window is aluminum window or beryllium window；And/or
The vacuum degree of the vacuum cavity is 10-6Millimetres of mercury~10-11Millimetres of mercury；And/or
The grid includes bracket and the aperture plate on the bracket, and the aperture plate has to be opened for what supplied for electronic penetrated
Mouthful；And/or
The tilt angle that the anode relative level is formed is 5 °~15 °；And/or
Relative distance between the carbon nanometer field-transmitting cathode, the grid, the focusing electrode and the anode passes through
Insulation spacer is adjusted.
Optionally, the photoacoustic imaging subsystem include exciting light needed for for providing photoacoustic imaging optical subsystem,
Acoustics subsystem for being acquired to multichannel photoacoustic signal and for adjusting the Exciting incidence degree to guarantee optics
Signal and acoustic signal keep the coplanar coplanar adjusting subsystem of optoacoustic.
Optionally, the optical subsystem includes excitation light source, lens group, fiber optic bundle and ring-shaped light bowl, the lens group
Between the excitation light source and the fiber optic bundle, the fiber optic bundle is fixed on the ring-shaped light bowl and is located at the lens
Between group and the ring-shaped light bowl.
Optionally, the acoustics subsystem include high-frequency transducer's array for being detected to acoustic signal and
The multi-channel data acquisition platform handled for the detectable signal to high-frequency transducer's array.
Optionally, high-frequency transducer's array includes the high-frequency transducer of multiple array distributions, the height
Frequency ultrasonic transducer is multi-layer laminate structure comprising acoustic lens, matching layer, the Piezoelectric anisotropy being cascading from front to back
Material layer, insulation back sheet.
Optionally, the animal scan control subsystem includes location structure for being positioned to animal and is used for
The Electromechanical Control platform for driving the animal on the location structure and the location structure to move along the vertical direction；And/or
Described image is rebuild to be included the image reconstruction mould group for carrying image reconstruction algorithm, carries figure with processing subsystem
As correcting and being registrated the image calibration quasi-mode group of software, the image co-registration mould group for carrying multi-modality images fusion software, carry
The information of information extraction and display software exports mould group.
Multi-modality imaging system provided by the utility model is mutually tied using static CT imaging subsystems with photoacoustic imaging subsystem
The multi-modality imaging technology formed is closed, the synchronous of toy structure and function information is realized and obtains, and relative to existing multimode
Imaging system have image resolution ratio is high, image taking speed is fast, imaging depth is big, dose of radiation is low, can long term monitoring advantage.Tool
Body, compared with prior art, the utility model has the following beneficial effects:
(1) the static CT imaging subsystems for using multiple beam carbon nanometer X source array only need to be each without mechanical rotation
It carries out being switched fast the CT scan that high speed can be realized between a carbon nanometer X source；And static state CT imaging subsystems overcome machine
The limitation of tool revolving speed has higher image taking speed, and eliminates artifact caused by movement, to can get higher space
Resolution ratio.Further, since multiple beam carbon nanometer X source array can carry out high-speed pulse transmitting, therefore, greatly reduce CT scan
Ineffective radiation dosage in the process, and then realize the effect of ultralow radiation.
(2) different from optical image technology, the spatial resolution of the sub- technology of photoacoustic imaging is and biological from ultrasonic signal
The ultrasonic scattering of tissue scatters weak two magnitudes than light, and therefore, the utility model both has bloom using photoacoustic imaging technology
Learn contrast, but also with ultrasound to the ability of deep tissue high-resolution imaging, while plus molecular probe can also have it is highly sensitive,
"dead", high specific advantage.
(3) static state CT imaging technique and photoacoustic imaging technology are merged with having complementary advantages, cooperate, each other compare
The advantages of feature, on the one hand high by static CT imaging resolution, ultralow radiation, it is easy to it is swollen to position to carry out three-dimensional visualization
Tumor tissue may be implemented tumour and turn on the other hand using the excellent soft tissue contrast of photoacoustic imaging and highly sensitive advantage
The early stage Accurate Diagnosis of shifting and the accurate description of drug metabolism.
Detailed description of the invention
In order to illustrate the embodiment of the utility model or the technical proposal in the existing technology more clearly, below will be to embodiment
Or attached drawing needed to be used in the description of the prior art is briefly described, it should be apparent that, the accompanying drawings in the following description is only
It is some embodiments of the utility model, for those of ordinary skill in the art, in the premise not made the creative labor
Under, the structure that can also be shown according to these attached drawings obtains other attached drawings.
Fig. 1 is the structural schematic diagram of multi-modality imaging system provided by the embodiment of the utility model；
Fig. 2 is the structural schematic diagram of carbon nanometer X source provided by the embodiment of the utility model.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describing, it is clear that described embodiment is only a part of the embodiment of the utility model, rather than all
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are not making creative work premise
Under every other embodiment obtained, fall within the protection scope of the utility model.
It is to be appreciated that the directional instruction (such as up, down, left, right, before and after ...) of institute in the utility model embodiment
It is only used for explaining in relative positional relationship, the motion conditions etc. under a certain particular pose (as shown in the picture) between each component, such as
When the fruit particular pose changes, then directionality instruction also correspondingly changes correspondingly.
It should also be noted that, when an element is referred to as being " fixed " or " disposed " on another element, it can be straight
Connect on the other element or may be simultaneously present centering elements.When an element is known as " connection " another element,
It, which can be, is directly connected to another element or may be simultaneously present centering elements.
In addition, the description for being related to " first ", " second " etc. in the present invention is used for description purposes only, and cannot understand
For its relative importance of indication or suggestion or implicitly indicate the quantity of indicated technical characteristic.Define as a result, " first ",
The feature of " second " can explicitly or implicitly include at least one of the features.In addition, the technical side between each embodiment
Case can be combined with each other, but must be based on can be realized by those of ordinary skill in the art, when the combination of technical solution
Conflicting or cannot achieve when occur will be understood that the combination of this technical solution is not present, also not in the requires of the utility model
Protection scope within.
As depicted in figs. 1 and 2, multi-modality imaging system provided by the embodiment of the utility model, including display 100, multimode
Imaging device 200 and the host 300 being electrically connected between display 100 and multi-modality imaging equipment 200 are equipped in host 300
Image reconstruction and processing subsystem (not shown), multi-modality imaging equipment 200 is interior to be equipped with animal scan control subsystem 210, static state
Computer tomography subsystem 220 (i.e. static state CT imaging subsystems) and photoacoustic imaging subsystem 230, stationary computers tomography
Imaging subsystems 220 include electronic control circuit 221, for generating X-ray 500 needed for stationary computers tomographic imaging scans
Multiple beam carbon nanometer X source array 222 is visited for the photon counting of computer tomography projection data acquisitions and high speed processing
Survey device 223 and the power supply 224 for powering for multiple beam carbon nanometer X source array 222, multiple beam carbon nanometer X source battle array
Column 222, photon counting detector 223 and power supply 224 are all electrically connected with electronic control circuit 221.Multi-modality imaging equipment
200 are mainly used for being scanned animal 400 imaging, and host 300 is mainly used at the information to multi-modality imaging equipment 200
Reason, display 100 are mainly used for intuitively exporting host 300 treated information.Wherein, it in multi-modality imaging equipment 200, moves
Object scan control subsystem 210 is mainly used for carrying animal 400 and carries animal 400 and moved, stationary computers tomography at
As subsystem 220 be mainly used for animal 400 carry out structure imaging, photoacoustic imaging subsystem 230 be mainly used for animal 400 into
Row functional imaging,
Specifically, in the utility model embodiment, son is imaged using the static CT of multiple beam carbon nanometer X source array 222
System need to only be carried out being switched fast the CT that high speed can be realized between each carbon nanometer X source 2220 and be swept without mechanical rotation
It retouches；And static CT system overcomes the limitation of mechanical separator speed, has higher image taking speed, and eliminates puppet caused by movement
Shadow, to can get higher spatial resolution.Further, since multiple beam carbon nanometer X source array 222 can carry out high rapid pulse
Punching transmitting, therefore, the ineffective radiation dosage during CT scan is greatly reduced, and then realize the effect of ultralow radiation.
In addition, since the spatial resolution of the sub- technology of photoacoustic imaging is from ultrasonic signal, and the ultrasound of biological tissue dissipates
It penetrates and scatters weak two magnitudes than light, therefore, the utility model embodiment had both had high optical contrast using photoacoustic imaging technology
Degree, but also with ultrasound to the ability of deep tissue high-resolution imaging, while plus molecular probe can also have it is highly sensitive, without radiation
Property, the advantage of high specific.
Since the imaging time of optoacoustic and static state two imaging subsystems of CT has difference, therefore, in system work, can lead to
The clock of stationary computers tomographic imaging subsystem 220 is crossed, the accurate trigger signal for controlling optoacoustic subsystem, so that it is according to quiet
The acquisition timing of state computer tomography subsystem 220, synchronizes and is acquired, so that the synchronous imaging of the two can be realized.
Multi-modality imaging system provided by the embodiment of the utility model is melted using static CT imaging technique with photoacoustic imaging technology
The scheme of conjunction has the characteristics that have complementary advantages, cooperates, compares each other, wherein on the one hand by static CT imaging resolution
The advantages of height, ultralow radiation, it is easy to it carries out three-dimensional visualization and carrys out positioning tumor tissue, it is on the other hand excellent using photoacoustic imaging
Soft tissue contrast and highly sensitive advantage, the early stage Accurate Diagnosis of metastases and the essence of drug metabolism may be implemented
Really description.Therefore, multi-modality imaging system provided by the embodiment of the utility model, using stationary computers tomographic imaging subsystem
220 combine the multi-modality imaging technology to be formed with photoacoustic imaging subsystem 230, have both realized 400 structure and function information of animal
It is synchronous obtain, and it is high with image resolution ratio, image taking speed is fast, imaging depth is big, dose of radiation is low, can long term monitoring it is excellent
Gesture.
Preferably, multiple beam carbon nanometer X source array 222 includes the carbon nanometer X source 2220 of multiple array distributions, and carbon is received
Rice X source 2220 includes vacuum cavity 2221, carbon nanometer field-transmitting cathode 2222, grid 2223, focusing electrode 2224 and anode
2225, carbon nanometer field-transmitting cathode 2222, grid 2223, focusing electrode 2224 and anode 2225 are all set in vacuum cavity 2221,
The inclination of the interval of anode 2225 is set to the top of carbon nanometer field-transmitting cathode 2222, and grid 2223 and focusing electrode 2224 are all received set on carbon
Between rice field-transmitting cathode 2222 and anode 2225, and grid 2223 is located at focusing electrode 2224 and carbon nanometer field-transmitting cathode 2222
Between, vacuum cavity 2221 is equipped with the X-ray exit window 2226 positioned at 2225 side of anode.Wherein, multiple beam carbon nanometer X source
Array 222 is used to generate the X-ray 500 of different crevice projection angles needed for static CT scan, and photon counting detector 223 is used for CT
The acquisition and high speed processing of data for projection, power supply 224 are used to power to multiple beam carbon nanometer X source array 222.Carbon nanometer
X source 2220 has the characteristic that electric current is stable, high pressure resistant property is good, focal spot is small, specifically, the pipe electricity of carbon nanometer X source 2220
Stream is greater than 0.1 milliampere, and tube voltage is greater than 50 kilovolts, and focus is less than 0.1 millimeter.
Preferably, each carbon nanometer X source 2220 is distributed in circular array or Polygonal arrays are distributed, carbon nanometer X-ray
The quantity in source 2220 is 90-180, is conducive to realize 360 ° of all standings of scanning angle in this way.
Preferably, X-ray exit window 2226 is aluminum window or beryllium window.
Preferably, the vacuum degree of vacuum cavity 2221 is 10-6Millimetres of mercury~10-11Millimetres of mercury.
Preferably, carbon nanometer field-transmitting cathode 2222 includes substrate and the cold-cathode material layer set on substrate surface.It is cold
Cathode material layer can be prepared by electrophoretic deposition or chemical vapour deposition technique, and shape and size can pass through photoetching work
Skill is accurately controlled；In addition, cold-cathode material layer be preferably shaped to ellipse or rectangle, it is each to size one to obtain
The focus of cause.
Preferably, substrate is metal substrate or the silicon wafer coated with metal coating；Metal substrate specifically can be stainless
Steel disc or copper sheet or titanium sheet or molybdenum sheet etc., metal coating specifically can be copper coating or titanium coating or molybdenum coating or iron
Deng.
Preferably, the material of cold-cathode material layer is the mixing of carbon nanotube or graphene and carbon nanotube and graphene
Object.
Preferably, carbon nanometer field-transmitting cathode 2222 is placed on the pedestal of vacuum cavity 2221.
Preferably, grid 2223 includes bracket and the aperture plate on bracket, and aperture plate has to be opened for what supplied for electronic penetrated
Mouthful.Grid 2223 is mainly used for electric field needed for providing cold-cathode material layer launching electronics.Opening on aperture plate is mainly used for protecting
Anode 2225 can be reached through grid 2223 by demonstrate,proving electronics.Aperture plate includes but is not limited to tungsten net or molybdenum net.
Preferably, the tilt angle A that 2225 relative level of anode is formed is 5 °~15 °.Anode 2225 is mainly used for electricity
The acceleration of beamlet, to obtain high energy electron.Anode 2225 has reflecting target, and reflecting target is mainly used for what reflective electron bombardment generated
X-ray 500.Reflecting target can be tungsten target or molybdenum target etc..
Specifically, focusing electrode 2224 is mainly used for focusing electron beam, to obtain the focus of required size.Focusing electrode 2224 is set
There is a focal aperture, focal aperture can be the round hole or non-rotationally-symmetric elliptical aperture or slot of rotational symmetry.
Preferably, between carbon nanometer field-transmitting cathode 2222, grid 2223, focusing electrode 2224 and anode 2225 it is opposite away from
It is adjusted from by insulation spacer (not shown), in this way, being conducive to reach optimal focusing effect.
Preferably, power supply 224 includes two mesolow power supplys and a high voltage power supply.Mesolow power supply is separately connected
In grid 2223 and focusing electrode 2224, voltage range 2kV-5kV；High voltage power supply is connected to anode 2225, power range 50kV-
140kV。
Specifically, photon counting detector 223 has high-speed data acquisition, high spatial resolution and ability resolution capability
Characteristic, can give full play to 222 high-speed pulse of carbon nanometer X source array exposure advantage.The shape of photon counting detector 223
Shape is that perhaps its X-ray transition material of polygon can be cadmium telluride or cadmium-zinc-teiluride to annular.Photon counting detector 223 is perpendicular
Histogram is preferably dimensioned to be greater than 0.5cm upwards, and pixel is preferably smaller than 100 microns.
Preferably, electronic control circuit 221 include pulsed drive and sequential control circuit, Current compliance control circuit with
And parallel exposure and data acquiring control circuit.Wherein, pulsed drive and sequential control circuit are for realizing carbon nanometer X source
2220 switch and the adjusting of time for exposure, and realize being switched fast between different carbon nanometer X sources 2220.Due to preparation
The limitation of technique, therefore, the field emission performance of cathode inevitably has differences, and Current compliance control system can pass through essence
2223 voltage of grid for really adjusting each carbon nanometer X source 2220 carrys out the emission current of Wehnelt cathode, to may make different carbon
Nanometer X source 2220 keeps the consistency of electric current during the work time, and then can guarantee that the exposure dose of different angle is identical.And
Trigger signal when row exposure is mainly opened by detector with data acquisition circuit triggers the unlatching of carbon nanometer X source 2220,
To realize that carbon nanometer X source 2220 exposes the synchronous progress acquired with detector data.
Preferably, pulsed drive and sequential control circuit include driving circuit, control circuit and isolation protective circuit.Its
In, driving circuit is preferably based on IGBT, and (Insulated Gate Bipolar Transistor, i.e. insulated gate bipolar are brilliant
Body pipe) driving circuit, be mainly used for realizing control of the weak electric signal to forceful electric power signal (kilovolt high pressure)；Control circuit is preferred
It is mainly used for the control circuit based on FPGA (Field-Programmable Gate Array, i.e. field programmable gate array)
In the output for the programmable signal for realizing high time precision；Isolation circuit, which is used primarily to ensure, effectively protects control system
Shield.
Preferably, Current compliance control circuit includes that grid current adjusts unit, grid current measuring unit and control
Element processed.
Specifically, multi-modality imaging equipment 200 further includes shell 240, animal scan control subsystem 210, stationary computers
Tomographic imaging subsystem 220 and photoacoustic imaging subsystem 230 are all set in shell 240.
Preferably, the optical subsystem of exciting light needed for photoacoustic imaging subsystem 230 includes for providing photoacoustic imaging
231, the acoustics subsystem 232 for being acquired to multichannel photoacoustic signal and for adjusting Exciting incidence degree to guarantee light
It learns signal and acoustic signal keeps the coplanar coplanar adjusting subsystem (not shown) of optoacoustic.Optical subsystem 231 is mainly used for mentioning
For exciting light needed for photoacoustic imaging comprising excitation light source and multi-wavelength optical focusing block.Acoustics subsystem 232 is mainly used
It is acquired in multichannel photoacoustic signal, mainly by high-frequency transducer's array 2321 and multi-channel data acquisition platform
2322 compositions.The coplanar adjusting subsystem of optoacoustic is mainly used for automatically adjusting Exciting incidence degree, to guarantee that light/sound remains
It is coplanar.
In a particular application, due to the heterogeneity of 400 body periphery of animal, therefore, in the entire scan mistake of animal 400
Cheng Zhong can not remain the coincidence of photo-acoustic excitation (light beam section) and optoacoustic detection (acoustic beam section), to cause signal-to-noise ratio
Decline, the reconstruction quality of strong influence image.And in the present embodiment, the coplanar adjusting subsystem of optoacoustic passes through CT real-time monitoring
The accurate size of 400 periphery of animal calculates the accurate location of the illumination plane of incidence, and then controls illumination incident angle, makes its beginning
It is coplanar with supersonic sounding position eventually, guarantee the high pump probe efficiency of optoacoustic.
Preferably, optical subsystem 231 includes excitation light source, lens group, fiber optic bundle and ring-shaped light bowl, and lens group, which is set to, to swash
Between light emitting source and fiber optic bundle, fiber optic bundle is fixed on ring-shaped light bowl and between lens group and ring-shaped light bowl.Lens group, light
Fine beam and ring-shaped light bowl collectively form multi-wavelength optical focusing block.Wherein, fiber optic bundle is mainly used for the biography of the coupling to exciting light
It is defeated；Ring-shaped light bowl is mainly used for fixed fiber optic bundle.
Preferably, excitation light source is the quick nanosecond pulse optical parametric oscillator of high energy；Lens group includes that spectroscope, plano-convex are saturating
Mirror, collimation lens and condenser lens.
Preferably, acoustics subsystem 232 includes high-frequency transducer's array for being detected to acoustic signal
2321 and the multi-channel data acquisition platform 2322 that is handled for the detectable signal to high-frequency transducer's array 2321.
High-frequency transducer's array 2321 is mainly used for detecting the acoustic signal inspired, concretely ring structure.
Multi-channel data acquisition platform 2322 is mainly used for the processing to detectable signal.Multi-channel data acquisition platform 2322 can be to high frequency
Each array element of ultrasound transducer array 2321 corresponds to the pre-processing channels such as individual data acquisition, amplification, filtering, so as to
Realize the real time high-speed acquisition and pretreatment of data.
Preferably, high-frequency transducer's array 2321 includes the high-frequency transducer of multiple array distributions, Mei Gegao
Frequency ultrasonic transducer corresponds to an array element of high-frequency transducer's array 2321.High-frequency transducer is multilayer laminated knot
Structure comprising acoustic lens, matching layer, piezo-electricity composite material layer, the insulation back sheet being cascading from front to back.
Preferably, animal scan control subsystem 210 include the location structure 211 for being positioned to animal 400 with
And the Electromechanical Control platform 212 for driving the animal 400 on location structure 211 and location structure 211 to move along the vertical direction.
Location structure 211 is mainly used for precisely fixing animal 400, and Electromechanical Control platform 212 is mainly used for control and realizes animal
400 effects moved along the vertical direction.
Preferably, image reconstruction and processing subsystem include the image reconstruction mould group for carrying image reconstruction algorithm, carrying
Have image rectification be registrated the image calibration quasi-mode group of software, the image co-registration mould group for carrying multi-modality images fusion software, hold
Carrying information, which is extracted, exports mould group with the information of display software.Image reconstruction mould group specifically carries CT image and photoacoustic image
Algorithm for reconstructing.
The utility model embodiment, which provides one kind, to be had high spatial resolution, big imaging depth, extremely low side effect, can grow
The 400 whole body living body multi-modality imaging technology and systems of animal of phase monitoring.Wherein, test proves that, stationary computers tomography at
Picture subsystem 220 has the advantages that image taking speed is fast, spatial resolution is high, ultralow radiation dosage, and photoacoustic imaging subsystem 230
Have the characteristics that imaging depth is big, highly sensitive and specific, and shows stationary computers tomographic imaging by demonstration
The fusion of system 220 and photoacoustic imaging subsystem 230 has feasibility.
The above is only the preferred embodiment of the present invention, and therefore it does not limit the scope of the patent of the utility model,
Under all utility models in the utility model are conceived, equivalent structure made based on the specification and figures of the utility model
Transformation, or directly/be used in other related technical areas indirectly and be included in the scope of patent protection of the utility model.
Claims (10)
1. multi-modality imaging system, which is characterized in that including display, multi-modality imaging equipment and be electrically connected at the display with
Host between the multi-modality imaging equipment, the host is interior to be equipped with image reconstruction and processing subsystem, and the multi-modality imaging is set
It is standby interior equipped with animal scan control subsystem, stationary computers tomographic imaging subsystem and photoacoustic imaging subsystem, the static state
Computer tomography subsystem includes electronic control circuit, for generating X-ray needed for stationary computers tomographic imaging scans
Multiple beam carbon nanometer X source array, for the photon counting of computer tomography projection data acquisitions and high speed processing visit
Survey device and for the power supply for the multiple beam carbon nanometer X source powering arrays, the multiple beam carbon nanometer X source battle array
Column, the photon counting detector and the power supply are all electrically connected with the electronic control circuit.
2. multi-modality imaging system as described in claim 1, which is characterized in that the multiple beam carbon nanometer X source array includes
The carbon nanometer X source of multiple array distributions, the carbon nanometer X source include vacuum cavity, carbon nanometer field-transmitting cathode, grid,
Focusing electrode and anode, the carbon nanometer field-transmitting cathode, the grid, the focusing electrode and the anode are all set to the vacuum
In cavity, the anode interval inclination is set to the top of the carbon nanometer field-transmitting cathode, and the grid and the focusing electrode are all
Between the carbon nanometer field-transmitting cathode and the anode, and the grid is located at the focusing electrode and carbon nanometer field
Between emitting cathode, the vacuum cavity is equipped with the X-ray exit window positioned at the anode side.
3. multi-modality imaging system as claimed in claim 2, which is characterized in that the carbon nanometer field-transmitting cathode include substrate with
And the cold-cathode material layer set on the substrate surface.
4. multi-modality imaging system as claimed in claim 3, which is characterized in that the substrate is metal substrate or is coated with golden
Belong to the silicon wafer of coating；And/or
The material of the cold-cathode material layer is the mixture of carbon nanotube or graphene and carbon nanotube and graphene.
5. such as the described in any item multi-modality imaging systems of claim 2 to 4, which is characterized in that the quantity of the carbon nanometer X source
It is 90-180；And/or
Each carbon nanometer X source is distributed in circular array or Polygonal arrays distribution；And/or
The X-ray exit window is aluminum window or beryllium window；And/or
The vacuum degree of the vacuum cavity is 10-6Millimetres of mercury~10-11Millimetres of mercury；And/or
The grid includes bracket and the aperture plate on the bracket, and the aperture plate has the opening penetrated for supplied for electronic；
And/or
The tilt angle that the anode relative level is formed is 5 °~15 °；And/or
Relative distance between the carbon nanometer field-transmitting cathode, the grid, the focusing electrode and the anode passes through insulation
Gasket is adjusted.
6. multi-modality imaging system as described in claim 1, which is characterized in that the photoacoustic imaging subsystem includes for providing
The optical subsystem of exciting light needed for photoacoustic imaging, the acoustics subsystem for being acquired to multichannel photoacoustic signal and for adjusting
The Exciting incidence degree is saved to guarantee that optical signalling and acoustic signal keep the coplanar coplanar adjusting subsystem of optoacoustic.
7. multi-modality imaging system as claimed in claim 6, which is characterized in that the optical subsystem include excitation light source, thoroughly
Microscope group, fiber optic bundle and ring-shaped light bowl, the lens group are set between the excitation light source and the fiber optic bundle, and the fiber optic bundle is solid
Due on the ring-shaped light bowl and between the lens group and the ring-shaped light bowl.
8. multi-modality imaging system as claimed in claims 6 or 7, which is characterized in that the acoustics subsystem includes for sound
Learn high-frequency transducer's array for being detected of signal and for the detectable signal to high-frequency transducer's array into
The multi-channel data acquisition platform of row processing.
9. multi-modality imaging system as claimed in claim 8, which is characterized in that high-frequency transducer's array includes multiple
The high-frequency transducer of array distribution, the high-frequency transducer are multi-layer laminate structure comprising from front to back successively
Acoustic lens, matching layer, piezo-electricity composite material layer, the insulation back sheet being stacked.
10. the multi-modality imaging system as described in any one of Claims 1-4 or 6 or 7, which is characterized in that the animal scanning control
Subsystem includes location structure for being positioned to animal and for driving the location structure and positioning knot
The Electromechanical Control platform that the animal on structure is moved along the vertical direction；And/or
Described image is rebuild to be included the image reconstruction mould group for carrying image reconstruction algorithm, carries image calibration with processing subsystem
Just be registrated the image calibration quasi-mode group of software, the image co-registration mould group for carrying multi-modality images fusion software, carry information
It extracts and exports mould group with the information of display software.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042110A (en) * | 2017-12-22 | 2018-05-18 | 深圳先进技术研究院 | Multi-modality imaging system |
| WO2021129816A1 (en) * | 2019-12-28 | 2021-07-01 | Shanghai United Imaging Healthcare Co., Ltd. | Imaging systems and methods |
-
2017
- 2017-12-22 CN CN201721812517.6U patent/CN209172280U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042110A (en) * | 2017-12-22 | 2018-05-18 | 深圳先进技术研究院 | Multi-modality imaging system |
| WO2021129816A1 (en) * | 2019-12-28 | 2021-07-01 | Shanghai United Imaging Healthcare Co., Ltd. | Imaging systems and methods |
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