CN1552282A - Blood pressure measuring method and device based on heart sound signal - Google Patents
Blood pressure measuring method and device based on heart sound signal Download PDFInfo
- Publication number
- CN1552282A CN1552282A CNA03138059XA CN03138059A CN1552282A CN 1552282 A CN1552282 A CN 1552282A CN A03138059X A CNA03138059X A CN A03138059XA CN 03138059 A CN03138059 A CN 03138059A CN 1552282 A CN1552282 A CN 1552282A
- Authority
- CN
- China
- Prior art keywords
- blood pressure
- electrocardiosignal
- pressure measuring
- cardiechema signals
- measuring method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Abstract
A method based on cardiac sound signals for measuring blood pressure features that the electronic triggering time of human heart and the mechanical closing time of cardiac valve, which are based on some points on cardiac sound signal, are used to measure the blood pressure by linear regression method. Its equipment is an air bag type non-destructive blood pressure measurer.
Description
Technical field
The present invention relates generally to the measurement of blood pressure, be particularly related to a kind of like this method and device, it calculates patient's systolic pressure by utilizing pulse delivery time between electrocardiosignal top and the next cardiechema signals top, mean pressure, diastolic pressure, thus a kind of new method and new equipment that can carry out continuous measurement to blood pressure provided in the non-intruding mode.
Technical background
Existing blood pressure measuring instrument can be divided into two big classes: damaged formula (invasive) sphygomanometer of a) directly measuring blood pressure with the remain-type ductus arteriosus: damaged formula (non-invasive) sphygomanometer of nothing of b) measuring blood pressure with indirect method.The former has certain risk to patient, infects and external haemorrhage because it may cause.Though the latter slightly owes accurately than the former, can bring safe, comfortable and convenient to patient, thereby be widely used in hospital, clinic and on a large scale in the generaI investigation, and be concerned about that by more and more the families of own blood pressure situation and individual use.
Blood pressure, an indication as individual physical condition is just receiving increasing concern, has promoted the improvement development of various indirect measurement of blood pressure methods thus.Current, the method for indirect measurement of blood pressure mainly comprises tone mensuration sphygomanometer, pulse sphygomanometer, light change in volume sphygomanometer and pulse delivery time method.
The ultimate principle that tone is measured sphygomanometer (Tonometry) is: when blood vessel was subjected to the external object compressing, the circumferential stress of blood vessel wall was eliminated, and at this moment intrinsic pressure the and external pressure of blood vessel wall equates.By to the tremulous pulse pressurization, need not directly to invade blood vessel tremulous pulse is flattened.Utilize one group to place surperficial eparterial array of pressure sensors measurement to make tremulous pulse keep flat pressure, the result who is drawn directly measures similar waveform to conduit, and reuse certain calculation method just can calculate each force value from waveform.But, this sphygomanometer to position, the angle of pick off, be added in eparterial pressure size all very responsive, and with respect to other sphygomanometers, their price is expensive excessively, does not obtain the success on the market.
Pulse sphygomanometer (Sphygmomanometer) utilizes an inflatable cuff to come blocking blood flow, and comes gaging pressure with a mercury gauge or aneroid manometer or electronic pressure gauge.Have the rubber bulb of valve alive to inflate with one to cuff, perhaps on automatic sphygmomanometer with adjustable air feeder inflation.When carrying out blood pressure measurement, with hands or open automatically rubber bulb live the valve venting so that the pressure in the cuff decrescence.Except cuff and piezometer, the 3rd important component part of pulse sphygomanometer is the listening device of answering Ke Shi (Korotkoff) sound.The inflated type cuff is tied up on patient's upper arm, and when the cuff inflation, it will block brachial artery.Stethoscope is placed on the cuff tip, the brachial dance place.The slowly emptying of air in cuff, the doctor just answers the Ke Shi sound with stethoscope.Auscultation (Auscultatory method) relies on everyone sensitivity and the discriminative power to sound.So this method is owing to the difference of interpersonal audition accuracy has strengthened the error of measuring.For improving the repeatability of test, adopt microphone to replace the work of people's ear in some automatic equipments.Automatically auscultation apparatus uses the operation method based on sound to come estimated systolic blood pressure and diastolic pressure.Micropkonic use has reduced the discriminative power to sound, has increased the sensitivity to interference sound simultaneously.But for making the result who measures automatically more reliable, vibratory drilling method is arisen at the historic moment.Vibratory drilling method (Oscillometricmethod) is to measure the amplitude of cuff internal pressure concussion, this value by blood flow by blood vessel and blood vessel wall is expanded record.The uniqueness of vibratory drilling method is to come with the air capacity in the cuff force value of monitor blood flow.This method can be used for measuring urgent rescue patient and the extra heavy Ke Shi sound that nurses.During use, the cuff of inflation is tied up on patient's upper arm.In deflation course, the pressure in the cuff doubles trickle arteriopalmus moment.The increase of moment of beating is because blood flow also will be resisted the pressure that exists in the cuff by brachial artery the time.The pressure of this instantaneous variation is by the perception of the institute of the piezoelectric transducer in the cuff.Therefore, during cuff deflation, this sensor record all pressure change.Different with auscultation is that what vibratory drilling method was measured is mean pressure, and utilizes it that systolic pressure, diastolic pressure are estimated.Ramsey (1991) points out, unique parameter that vibratory drilling method is measured is a mean arterial pressure, is a strongest data that can compare with systolic pressure, diastolic pressure.Because it records when being cuff pressure shock range maximum.This characteristic makes that the value of mean arterial pressure is very reliable, even under the weak excessively situation of hypopiesia, vasoconstriction and pulse.When the clinician want to obtain accurately pressure value with cuff formula pulse sphygomanometer, the cuff of selecting suitable size was very important.The pressure hypothesis that acts on arterial wall is to equate with pressure in the cuff of outside.Yet the pressure in the cuff is by its intermediary material Transfer.When cuff has enough width and length, the tremulous pulse under the pressure in the cuff just can be delivered to equably.When a slight cuff be used in one too big strong hand arm time error will produce.At this moment pressure can not act on the tremulous pulse that has certain-length under the cuff equably, but converges.Another problem of cuff formula pulse sphygomanometer is that it can not be measured continually.During use, must earlier give the cuff inflation, make its pressure reach for example 160mmHg with the time in several seconds, then with each seconds two millimetres of mercury speed make pressure decline, that is, drop to about 60mmHg with about 50 seconds time chien shih pressure.So complete blood pressure determination was finished general needs about one minute.Confluxing of arm hypomere venous blood will have influence on the accuracy of the blood pressure measurement that next time on same arm, carries out and stop with cuff constantly.
Light change in volume (Photoplethysmograph or PPG) sphygomanometer is widely known by the people now.It utilizes light to come the variation of patient's blood flow in perception and the record heart loop process.Because it is the equipment of no damaged formula, people just are devoted to carry out with it the research of blood pressure measurement.For example, in U.S. Patent No. 5,269, disclose a kind of method of utilizing light change in volume method to carry out blood pressure measurement in 310.This method utilizes the relation between blood pressure and the blood flow to measure blood pressure.Though this method can not have the blood pressure measurement of damaged formula easily, it need assist calculating blood pressure with computer, and still can not carry out continuous blood pressure and measure.
A kind of method that can be used to frequently to measure blood pressure is to utilize the damaged formula sphygomanometer of the nothing that is enclosed within on the finger.During use, on patient's finger, put a latex finger-stall, the capsule bag of a dress water is arranged in this latex finger-stall, absolute pliability is arranged.The hydraulic pressure of water pocket Dai Li is just adjusted to the diastole that is lower than patient and is pressed.When heart shrinks so that blood flow stream when crossing finger tip, finger tip will swell, thereby hydraulic pressure sensor is produced pressure.The pressure that the periphery blood flow pours in the undulatory property of finger tip generation adds that lasting hydraulic pressure is exactly the output valve of pressure transducer.The method of the measurement periphery blood pressure of the damaged formula of the nothing that the damaged formula sphygomanometer on the finger is an economy.
Also has a kind of method that is called impedance volumetric method (impedance plethysmograph), the change in volume when being used for measuring the tremulous pulse expansion.The variation of measured place tremulous pulse volume can change its electrical conductivity (impedance).Value tracing different time records just obtains the impedance waveform, is similar to the light volume waveform of pressure and estimates pressure value.
Yet, think all that based on the above-mentioned smooth volumetric method or the sphygomanometer of impedance volume graphical method it is relevant that blood pressure changes with volume of blood flow, and from the variation of volume, obtain data.Though both sometimes are similar, be not like this constantly.So continuing to carry out blood pressure measurement does not also need a kind of very actual useful method with will having damaged formula.
Also having a kind of method is to use the relation between arterial pressure and the pulse wave velocity to determine that blood pressure, its title are pulse wave velocity (Pulse wave velocity or PWV) or pulse delivery time method (Pulse Transit Time or PTT).From the statistics viewpoint, pulse wave velocity is the sign of age and blood pressure.Pulse wave velocity is the sign of blood vessel elasticity with corresponding pulse propagation time in the certain distance.When increased blood pressure, vasodilation makes the blood vessel hardening, and pulse wave velocity is accelerated.Therefore, pulse wave velocity or the variation of the pulse delivery time variation that can draw blood pressure.Principle with the pulse wave velocity measuring blood pressure will obtain step description in the back.Need use the instrument (as cuff formula sphygomanometer) of other measuring blood pressures to proofread and correct based on the monitoring of blood pressure instrument of pulse delivery time.
Work as timing, need to measure blood pressure and pulse delivery time under rest state and the kinestate.Suppose that blood pressure and pulse delivery time under rest state are P1 and T1, and they are respectively P2 and T2 under the kinestate, and correlation coefficient is M and C, then pressure value P1 and P2 can be by following formulates:
P1＝M×T1+C
P2＝M×T2+C
Equation above observing is because P1, P2, T1 and T2 value are to determine that M and C can determine that then then pressure value can only be obtained by the pulse delivery time at timing when measuring.Therefore, when utilizing this method to measure blood pressure, the correlation coefficient M and the C that must obtain the pulse transmission time and obtain by correction.Measuring blood pressure by the pulse transmission speed is no damaged formula, and can continuous measurement.But,, thereby strengthened the pseudo-shadow that moves, the continuous measurement when therefore this method is not adapted at moving owing to pick off also can measure other signals that limb motion produces.
Summary of the invention
Therefore, the present invention makes at the above-mentioned problems in the prior art, its objective is damaged formula continuous blood pressure measuring method of the nothing that a kind of novelty is provided and device.
To achieve these goals, described according to a first aspect of the invention, it provides a kind of blood pressure measuring method based on cardiechema signals, and this method may further comprise the steps: 1) gather electrocardiosignal on one's body from the measured; 2) gather cardiechema signals on one's body from the measured; 3) on described electrocardiosignal that collects and cardiechema signals, select a reference point respectively; 4) time difference between described two reference points of calculating; 5) other required parameter during calculating blood pressure is measured; And 6) pass through with described time difference and described other parameter substitution one blood pressure measurement formula, to calculate blood pressure measurement.
According to the present invention aspect first in described method, the reference point on the described electrocardiosignal be on the R type ripple in the electrocardiosignal a bit, be preferably the top point of R type ripple.Reference point on the described cardiechema signals be on the second heart sound signal in the cardiechema signals a bit, be preferably the top point of second heart sound signal, the absolute value maximum that preferably utilizes the second heart sound signal is as its top point.
Can also comprise the step of described time difference being got multiple averaging in the described step 4), described multiple averaging is preferably 10 times at least.
In an embodiment of the present invention, described step 5) further comprises the step of reference data calculating blood pressure that utilization records in advance other required parameter in measuring.The described reference data that records in advance can be imported by external equipment, also can read from a memory device.
In addition, the blood pressure measurement of calculating in described step 5) can be systolic pressure, mean pressure or diastolic pressure.
Described according to a second aspect of the invention, it provides a kind of blood pressure measuring device based on cardiechema signals, and this device comprises: the electrocardiosignal sensing unit is used for perception measured's electrocardiosignal; The cardiechema signals sensing unit is used for perception measured's cardiechema signals and it is converted into the signal of telecommunication from acoustical signal; Early stage, signal processing unit was used for the signal from described electrocardiosignal induction module or described cardiechema signals induction module is filtered and amplifies; And data processor, it and described early stage signal processing unit be of coupled connections, be used to receive described electrocardiosignal and cardiechema signals, and blood pressure calculated to obtain blood pressure measurement according to blood pressure measurement formula and described electrocardiosignal and described cardiechema signals.
In the described device, described device also comprises aspect second according to the present invention: input block, and it links to each other with described data processor, is used to import the required parameter of calculating blood pressure; And memory element, it links to each other with described data processor, is used for required parameter of storage computation blood pressure and formula.In addition, described device also can comprise the wireless transmission unit, and it also links to each other with described data processor, is used for sending the blood pressure measurement that described data processor calculates to the far-end receiving system to do further processing.Described device also can comprise an outer housing, is used for supporting and putting described device.
Described electrocardiosignal sensing unit comprises the pick off that is used to detect electrocardiosignal, and this pick off can adopt but be not limited to three conducting electrodes, and the size of these three conducting electrodes both can be the same or different.
Described cardiechema signals sensing unit comprises the pick off that is used to detect cardiechema signals, and this pick off can adopt has certain thickness thin film, also can adopt mike, in order to convert described cardiechema signals to the signal of telecommunication from acoustical signal.
Can be applied to making things convenient for patient's long periods of wear to use in the middle of the small-sized blood pressure measurement device such as wrist formula wrist-watch according to device of the present invention, thereby realize blood pressure measurement non-intrusion type, successive, miniaturization.In addition, in some applications, can also utilize unlimited data transmission module that the pressure value that records is reached the alarm signal of undesired pressure value is passed to professional health care personnel at a distance with wireless mode, so that medical personnel monitor in real time to the patient.
Description of drawings
Below in conjunction with accompanying drawing the specific embodiment of the present invention is elaborated, by these explanations, it is clearer that above-mentioned purpose of the present invention, advantage and feature will become.In following accompanying drawing:
Fig. 1 is used for explanation and how utilizes electrocardiosignal and cardiechema signals to detect the pulse delivery time;
Fig. 2 is the flow chart of the inventive method when integrated operation;
Fig. 3 is the flow chart of the inventive method when debugging mode is operated;
Fig. 4 is the flow chart of the inventive method when detecting electrocardiosignal top and cardiechema signals top;
Fig. 5 is that the inventive method is detecting the flow chart of pulse during the delivery time;
Fig. 6 is the flow chart of the inventive method when utilizing each parameter to come calculating blood pressure;
Fig. 7 is the graphic extension of the inventive method, is used to explain blood pressure and the relation of pulse delivery time;
Fig. 8 (a), 8 (b) and 8 (c) are respectively according to front view, rearview and the side view of the described blood pressure measuring device of the embodiment of the invention when specifically using;
Fig. 9 is the structural representation block diagram according to the described blood pressure measuring device of the embodiment of the invention.
The specific embodiment
At first will be specifically described the described method of the embodiment of the invention referring to figs. 1 to Fig. 7.
Between the triggered time of electrocardiosignal and heartbeat, there is certain relation.And there is certain relation in the deadline of cardiechema signals and heartbeat.Blood begins to flow after the cardiac pumping, and behind the pump blood agglomeration bundle, blood is flowed back to heart by the cardiac valve prevention.First heart sound produces owing to Tricuspid valve and mitral closure.Second heart sound is then by valve of pulmonary trunk and aortic valve and produce.They all are to stop blood to flow back to heart from health.
Time difference between electrocardiosignal and the second heart sound signal has comprised the blood pressure information.Hypertensive the time, blood flow is accelerated, this moment valve of pulmonary trunk and aortic valve close than normal the time fast.As a result, will produce short electrocardiosignal and the time difference of second heart sound signal, be called as the pulse delivery time (pulse transit time or PTT).
Therefore, between pulse delivery time and blood pressure, exist specific relation.The present invention just is based on above-mentioned principle and carries out blood pressure measurement.
By 15 measured's measurement result is analyzed, can obtain the relation between pulse delivery time and the blood pressure, its result is as shown in Figure 7.Pulse delivery time and blood pressure can be by following The Representation Equation:
Blood pressure=M * PTT+C
Wherein, M and and C be the coefficient of this linear equation, for different measured, its numerical value is different.Therefore, must transfer survey earlier before measuring, to determine regression coefficient M and the C with the corresponding linear equation of measured.As long as determine coefficient M and C in the above-mentioned equation, just can calculate pressure value by measuring the pulse delivery time (PTT).Its detail will obtain respectively describing in the back.
Fig. 1 is used for explanation and how utilizes electrocardiosignal and cardiechema signals to detect the pulse delivery time.As shown in Figure 1, time 110, time 120 and time 130 are represented the time amplitude of electrocardiosignal and cardiechema signals respectively.Time 110 is tops of electrocardiosignal, and the time 120 is tops of first heart sound, and the time 130 is tops of second heart sound.These time values have been represented the reference value of decision pulse delivery time.The pulse delivery time 140 is the time difference of time 110 and time 130.The pulse delivery time 140 is the indexs that are used to predict systolic pressure, mean pressure and diastolic pressure.
As shown in Figure 1, the absolute amplitude place of cardiechema signals is proposed as reference point, in particular, because the amplitude of cardiechema signals can often change, thus utilize absolute value can eliminate the influence of phase place, and blood pressure information more accurately is provided.
Fig. 2 is the flow chart of the inventive method when integrated operation.As shown in Figure 2, mainly comprise 4 steps according to the method that is used to measure blood pressure of the present invention.At first, in step 210, enter the survey pattern of transferring.Need to determine some required parameters in the blood pressure measurement process in this pattern, its detailed process will obtain describing in detail in the back.Then, carry out the top detection algorithm in step 220, it is used to determine the vertical time location of electrocardiosignal 110 and the vertical time location of cardiechema signals 130.Next, in step 230, decide the value of pulse delivery time 140 according to the time difference between the top of electrocardiosignal 110 and cardiechema signals 130.Next step determines in step 240 whether the sum of place's pulse delivery time reaches preset value (for example 10 times).Use the single pulse delivery time to go to determine blood pressure will have many factors of instability, thereby increase the error that blood pressure detects.In the described method of the embodiment of the invention, adopted the meansigma methods of 10 pulse delivery times.Step 220 need be repeated until 10 pulse delivery times detected till.Next step, in step 250, blood pressure measurement parameter and the measured difference substitution average time blood pressure measurement formula of step 230 by being obtained in the accent survey pattern with step 210 just can calculate blood pressure, comprise systolic pressure, mean pressure and diastolic pressure.After determining blood pressure, the pressure value that records will be transmitted to step 260 whether judging normally, if pressure value not in range of normal value, then system can send wrong information, and in step 270 blood pressure measurement is shown.Other if desired blood pressure measurement, then step 280 is with repeating step 210,220,230,240,250,260 and 270.
Below will be elaborated to above-mentioned 4 key steps 210,220,230 and 250.
Fig. 3 is the flow chart of the inventive method when debugging mode is operated.As shown in Figure 3, in step 310, the blood pressure that user utilizes standard-sphygmomanometer to record by input keyboard input, and they are kept in the middle of the memory element.In the present embodiment, we represent diastolic pressure, represent mean pressure, represent systolic pressure with Dia_cal with Mea_cal with Sys_cal.These three variablees can be stored with the form of array, and the size suggestion of array is triplex row four row.
Next step, the function of step 320 is the same with the function of step 220.
Next step, the function of step 330 is the same with the function of step 230.
Next step, the function of step 340 is the same with the function of step 240, its preset value also is the same with the preset value of step 240 (for example 10).
Above-mentioned steps 220,230 and 240 will be further specified in the back.
Set up a personalized linear regression line, need four groups reference pressure value and pulse delivery time at least.Then, whether the group number of step 350 decision pulse delivery time equals preset value, and in the present embodiment, its preset value is 4.Step 320,330 and 340 is need be repeated until till the arrival of four group pulse delivery times.
Four groups are stored as Sys_cal (1), Sys_cal (2), Sys_cal (3) and Sys_cal (4) respectively with reference to systolic pressure.Four groups are stored as Mea_cal (1), Mea_cal (2), Mea_cal (3) and Mea_cal (4) respectively with reference to mean pressure.Four groups are stored as Dia_cal (1), Dia_cal (2), Dia_cal (3) and Dia_cal (4) respectively with reference to diastolic pressure.Four groups of reference pulse delivery times of calculating in the step 320,330 and 340 then are stored as PTT_cal (1), PTT_cal (2), PTT_cal (3) and PTT_cal (4) respectively.In step 360,, just can determine each regression coefficient M1, M2, M3, C1, C2 and C3 in the linear regression line by following equation according to above-mentioned four groups of standard pressure values and corresponding pulse delivery time:
M1＝SXY_Sys/SSX_PTT (1)
M2＝SXY_Mea/SSX_PTT (2)
M3＝SXY_Dia/SSX_PTT (3)
C1＝ Sys_cal-M1× PTT_cal (4)
C2＝ Mea_cal-M2× PTT_cal (5)
C3＝ Dia_cal-M3× PTT_cal (6)
In above-mentioned equation, i represents repeated index, n represents the quantity of referential array, its numerical value is 4 in the present embodiment, M1 and C1 are the coefficients that is used to set up the systolic pressure equation of linear regression, M2 and C2 are the coefficients that is used to set up the mean pressure equation of linear regression, and M3 and C3 are the coefficients that is used to set up the diastolic pressure equation of linear regression.
Next step, in step 370, coefficient M1, M2, M3, C1, C2 and C3 are saved into memory element, are used for later blood pressure measurement and calculate.
Fig. 4 is the flow chart when detecting electrocardiosignal top and cardiechema signals top in the step 220 shown in Figure 2.As shown in Figure 4, in the middle of the algorithm of top detection, in order to lower behaviour's influence that tone signal caused, the amplitude pre-value of electrocardiosignal need be set.Be effective electrocardiosignal when the amplitude numerical value of electrocardiosignal just should be during greater than its amplitude pre-value promptly, top point is also looked in this effective numerical value.The amplitude numerical value of all electrocardiosignaies is by normalized, and its numerical range should be between 0 and 1.In the present embodiment, the amplitude pre-value of electrocardiosignal is 0.6 and is stored in step 410.The effectiveness of amplitude pre-value is obtained in experiment according to 15 former measured.
Next step, in step 420, all amplitude numerical value just are retained greater than the electrocardiosignal of amplitude pre-value, and other signal less than the amplitude pre-value is then deleted.As a result, all amplitudes will form a new inferior array greater than the signal of amplitude pre-value.In step 430, find out the electrocardiosignal numerical value of amplitude maximum in new inferior array, and find out corresponding time value.And this time value promptly is the position of electrocardiosignal top point.After step 410,420 and 430 processing, in the time of each heart beating, the top point of electrocardiosignal just can be detected.At last, in step 440,, also the position probing of cardiechema signals top point is come out according to the position of electrocardiosignal top point.
Fig. 5 is that step 230 shown in Figure 2 is detecting the flow chart of pulse during the delivery time.As shown in Figure 5, in step 510, electrocardiosignal top point is calculated with the time difference of cardiechema signals top point, and this time difference is defined as the pulse delivery time.Then, in step 520, relatively whether the numerical value of pulse delivery time exceeds default numerical range.In the present embodiment, the numerical value of preset value is 200 milliseconds to 400 milliseconds, and its numerical value is obtained in experiment according to 15 measured.If the pulse delivery time of step 510 output has exceeded the scope of preset value, then step 520 will be deleted its pulse delivery time and controlled step 220 and be gone repetition once top point detection in addition.If then step 530 will be preserved pulse delivery time value in the middle of the memory element, be used for later blood pressure measurement within the scope of preset value the detected pulse delivery time.The meansigma methods of pulse delivery time is based on a plurality of heart beating number of times and obtains, and its number of times is being preestablished in step 240.In the present embodiment, the preset value of number of times is 10 times.
Fig. 6 is the flow chart of step 250 shown in Figure 2 when calculating blood pressure.As shown in Figure 6, in step 610, data processor calculates measured's systolic pressure by using the correlation coefficient that is stored in the memory element, and its computing formula formula is:
Sys_out＝M1×PTT_ave+C1 (7)
Wherein, Sys_out represents measured's systolic pressure, and M1 and C1 are the correlation regression coefficients that calculates in transferring the survey pattern, and as shown in Figure 3, they are saved in step 370.PTT_ave is the parameter that is calculated by pulse delivery time calculating function shown in Figure 5, and it is saved in step 530.
In step 620, the mean pressure that the data processor utilization is calculated the measured with the correlation coefficient that is stored in the memory element, its equation is:
Mid_out＝M2×PTT_ave+C2 (8)
Wherein, Mid_out represents measured's mean pressure, and M2 and C2 are the correlation regression coefficients that calculates in transferring the survey pattern, and as shown in Figure 3, they are saved in step 370.PTT_ave is the parameter that is calculated by pulse delivery time calculating function shown in Figure 5, and it is saved in step 530.
In step 630, the data processor utilization uses the correlation coefficient that is stored in the memory element to calculate measured's diastolic pressure, and its equation is:
Dia_out＝M3×PTT_ave+C3 (9)
Wherein, Dia_out represents measured's diastolic pressure, and M3 and C3 are the correlation regression coefficients that calculates in transferring the survey pattern, and as shown in Figure 3, they are saved in step 370.PTT_ave is the parameter that is calculated by pulse delivery time calculating function shown in Figure 5, and it is saved in step 530.
At last, in step 640, the systolic pressure that records, mean pressure and diastolic pressure are output, and control is given step 260 then, as shown in Figure 2.
Fig. 7 is the graphic extension of the inventive method, is used to explain blood pressure and the relation of pulse delivery time.Figure 7 illustrates one based on the measured and with four groups of rectilinear linear regression lines of setting up with reference to systolic pressure and four group pulse delivery times.It is-0.99001 that square among the figure is expressed regression coefficient, and its probability is 0.00999.Notice that in the middle of regression data was analyzed, the high more and probability of regression coefficient (absolute value) is low had more represented when setting up linear regression line the error between its four groups of reference datas (systolic pressure and pulse delivery time) and linear regression line more little.Its detail can be with reference to Chatterjee Samprit 1938, " simple linear regression " (Simple Linear Regression), inRegression analysis by example, New York, Wiley, 2000.Eight groups of trianglees among Fig. 7 have shown eight groups of measurement data, its mean error equals-5.3132mmHg, standard variance is 7.6508mmHg, and above numerical value is according to the error gained between the pressure value of standard-sphygmomanometer and blood pressure measuring device of the present invention output.
Next will be specifically described the described device of the embodiment of the invention with reference to figure 9 and Fig. 8 (a), 8 (b) and 8 (c).
Fig. 9 is the structural representation block diagram according to the described blood pressure measuring device of the embodiment of the invention.As shown in Figure 9, this device comprises electrocardiosignal sensing unit 910, cardiechema signals sensing unit 920, early stage signal processing unit 930, input block 940, memory element 950, data processor 960, agitator 970 and wireless transmission unit 980.
Electrocardiosignal sensing unit 910 is used to respond to the signal of telecommunication that is produced by human body, is used to collect electrocardiosignal in device of the present invention.This sensing unit is not limited to dried electrode, also can be wet electrode.Electrocardiosignal by 910 outputs of electrocardiosignal sensing unit is sent to signal processing unit 930 in early stage.Cardiechema signals sensing unit 920 is used to respond to the acoustical signal that is produced by human body and change this acoustical signal into the signal of telecommunication, and it is used to collect cardiechema signals in an embodiment of the present invention.This induction apparatus is not limited to Electret Condencer Microphone, also can be piezoelectric transducer.Cardiechema signals by 920 outputs of cardiechema signals sensing unit also is sent to signal processing unit 930 in early stage.Early stage, signal processing unit 930 was used at a certain frequency band and the selected signal of wave amplitude inner filtration.In device of the present invention, 910 induced electrocardiosignaies of electrocardiosignal sensing unit are adjusted to the wave amplitude gain coefficient and equal 1000, and its frequency band is adjusted to 5 to 40Hz.920 induced cardiechema signals of cardiechema signals sensing unit then are adjusted to the wave amplitude gain coefficient and equal 40, and its frequency band is adjusted into 25 to 1000Hz.The signal of signal processing unit 930 outputs is transmitted to data processor 960 by early stage.Input block 940 is mainly used in transfers the survey pattern, and the parameter of its input is stored in memory element 950.In an embodiment of the present invention, input block can be keyboard input devices, can certainly other input equipment.Memory element 950 is in store by parameter and the calculating blood pressure required formula (will in the back obtain explanation) of user by input block 940 inputs.The function of data processor 960 is: 1) collect by the signal of signal processing unit processes in early stage, detect electrocardiosignal and cardiechema signals the top point, calculate the time difference between their top points; 2) collect parameter by input block 940 inputs, and in debugging mode design factor; 3), and utilize blood pressure measurement formula and the actual pulse delivery time that records to calculate systolic pressure, mean pressure and diastolic pressure according to the coefficient that calculates at debugging mode.In addition, it can also have its function, for example, sends the blood pressure that has calculated to wireless transmission unit 980.The signal of data processor 960 usefulness agitators 970 is as its clock signal.Agitator 970 provides a clock signal to data processor 960, and it can be moved.Wireless transmission unit 980 is used to receive the pressure value that is calculated by data processor 960, and its signal is sent to display or far-end receiving system to carry out post-processed.
For the person of ordinary skill of the art, because each building block in the said apparatus all is a technique known, for example, can pass through below with reference to their particulars of document acquisition: 1) M.J.Burke, " be used for low power ECG amplifier/detector that dried electrode heart rate monitors " (Low-power ECG amplifier/detector for dry-electrode heart ratemonitoring), Medical ﹠amp; Biological Engineering ﹠amp; Computing, vol.32, pp.678-83,1994; 2) Sergio Franco, " active filter: chapter 1; operational amplifier and Analogous Integrated Electronic Circuits design-second edition " (Active Filters:Part I, in Design withOperational Amplifiers and Analog Integrated Circuits-2nd edition), NewYork, The McGraw-Hill Companies, 1997; 3) Lai Qiwen, " 8051 single-chip embedded systems: cross the threshold and practice is used ", the Taibei, civilian stalwart information limited company, 2002; And 4) Ian Hickman, and " chapter 3: the RF part in simulation and the RF circuit " (Part 3:RF ", in Analog ﹠amp; RF Circuits), Oxford, Newnes:An Imprint ofButterworth-Heinemann, 1998, therefore no longer it is elaborated herein.
Fig. 8 (a), 8 (b) and 8 (c) are respectively according to front view, rearview and the side view of the described blood pressure measuring device of the embodiment of the invention when specifically using.Shown in Fig. 8 (a), thin film 810 is used to collect acoustic signal, and it is used as the cardiechema signals sensing unit of collecting cardiechema signals in device of the present invention, and its thin film has certain thickness (for example 0.25 millimeter).Three conductive electrodes 820,830 and 840 are used to collect the signal of telecommunication, and it is used as the electrocardiosignal sensing unit of collecting electrocardiosignal in device of the present invention, its size can unanimity also can be inconsistent.Pectoral girdle 850 has certain elasticity, is made by insulator, and it is fixed on measured's front to device of the present invention with socket 860 and 870.Thin film 810 is fixed on the place ahead of instrument outer housing 880, and outwards little curved, is used to obtain signal more clearly.Three conductive electrodes 820,830 and 840 are by average fixed the place ahead at instrument outer housing 880.Thin film 880 is designed to by the outstanding outer housing 880 of the distance that equates, shown in Fig. 8 (c) with three conductive electrodes.Instrument outer housing 880 is become by the insulated with material system that is similar to artificial resin, is used for preventing the short circuit of conductive electrode 820,830 and 840.
Shown in Fig. 8 (b) and 8 (c), integrated package 890 is fixed in the back side of instrument outer housing 880.Integrated package 890 comprises: data processor, early stage signal processing unit, memory element, input block, agitator and wireless transmission unit; Its function is: carry out signal filtering, carry out letter gain control, in transferring the survey pattern, calculate the required parameter of blood pressure measurement, carry out the detection of electrocardiosignal top point and cardiechema signals top point, the time difference of carrying out between electrocardiosignal top point and the cardiechema signals top point detects, store a equation of linear regression about pulse delivery time and blood pressure, allow user input transfer parameter in the survey pattern, according to the coefficient of transferring in the survey pattern, the equation of pulse delivery time and storage calculates systolic pressure, mean pressure and diastolic pressure, and the blood pressure that calculates is transferred to receiving terminal shows.
Claims (22)
1. blood pressure measuring method based on cardiechema signals, this method may further comprise the steps:
1) gathers electrocardiosignal on one's body from the measured;
2) gather cardiechema signals on one's body from the measured;
3) on described electrocardiosignal that collects and cardiechema signals, select one or more reference points respectively;
4) calculate time difference between the reference point on reference point and the corresponding cardiechema signals on the described electrocardiosignal;
5) other required parameter during calculating blood pressure is measured; And
6) pass through with described time difference and described other parameter substitution blood pressure measurement formula, to calculate blood pressure measurement.
2. blood pressure measuring method as claimed in claim 1 is characterized in that, the blood pressure measurement formula in the described step 6) comprises following formula: blood pressure=M * PTT+C, and wherein, M and C are parameter required in the described blood pressure measurement, and PTT then is described time difference.
3. blood pressure measuring method as claimed in claim 1 or 2 is characterized in that, the reference point on the described electrocardiosignal is the point on the R type ripple in the electrocardiosignal.
4. blood pressure measuring method as claimed in claim 3 is characterized in that, the reference point on the described electrocardiosignal is the top point of the R type ripple in the electrocardiosignal.
5. blood pressure measuring method as claimed in claim 1 or 2 is characterized in that, the reference point on the described cardiechema signals is the point on the second heart sound signal in the cardiechema signals.
6. blood pressure measuring method as claimed in claim 5 is characterized in that, the reference point on the described cardiechema signals is the top point of the second heart sound signal in the cardiechema signals.
7. blood pressure measuring method as claimed in claim 6 is characterized in that, the top point of described second heart sound signal is the point of absolute value maximum in the second heart sound signal.
8. blood pressure measuring method as claimed in claim 1 or 2 is characterized in that, also comprises the step of described time difference being got multiple averaging in the described step 4).
9. blood pressure measuring method as claimed in claim 8 is characterized in that described multiple averaging is 10 times at least.
10. blood pressure measuring method as claimed in claim 1 or 2 is characterized in that, described step 5) further comprises the step of reference data calculating blood pressure that utilization records in advance required parameter in measuring.
11. blood pressure measuring method as claimed in claim 10 is characterized in that, the described reference data that records in advance can be imported by external equipment, also can read from a memory device.
12. blood pressure measuring method as claimed in claim 1 or 2 is characterized in that, the blood pressure measurement of calculating in described step 5) is systolic pressure, mean pressure or diastolic pressure.
13. the blood pressure measuring device based on cardiechema signals, this device comprises:
The electrocardiosignal sensing unit is used for perception measured's electrocardiosignal;
The cardiechema signals sensing unit is used for perception measured's cardiechema signals and it is converted into the signal of telecommunication from acoustical signal;
Early stage, signal processing unit was used for the signal from described electrocardiosignal induction module or described cardiechema signals induction module is filtered and amplifies; And
Data processor, it and described early stage signal processing unit be of coupled connections, be used to receive described electrocardiosignal and cardiechema signals, and blood pressure calculated to obtain blood pressure measurement according to blood pressure measurement formula and described electrocardiosignal and described cardiechema signals.
14. blood pressure measuring device as claimed in claim 13 is characterized in that, described device also comprises:
Input block, it links to each other with described data processor, is used to import the required parameter of calculating blood pressure; And
Memory element, it links to each other with described data processor, is used for required parameter of storage computation blood pressure and formula.
15. blood pressure measuring device as claimed in claim 13 is characterized in that, described device also comprises:
The wireless transmission unit, it links to each other with described data processor, is used for sending the blood pressure measurement that described data processor calculates to the far-end receiving system to do further processing.
16. blood pressure measuring device as claimed in claim 13 is characterized in that, described device also comprises an outer housing, is used for supporting and putting described device.
17. blood pressure measuring device as claimed in claim 13 is characterized in that, described electrocardiosignal sensing unit comprises the pick off that is used to detect electrocardiosignal.
18. blood pressure measuring device as claimed in claim 17 is characterized in that, described pick off is three conducting electrodes.
19. blood pressure measuring device as claimed in claim 18 is characterized in that, described three conducting electrodes measure-alike.
20. blood pressure measuring device as claimed in claim 13 is characterized in that, described cardiechema signals sensing unit comprises the pick off that is used to detect cardiechema signals.
21. blood pressure measuring device as claimed in claim 20 is characterized in that, described pick off is for having certain thickness thin film.
22. blood pressure measuring device as claimed in claim 20 is characterized in that, described pick off is a mike, is used for converting described cardiechema signals to the signal of telecommunication from acoustical signal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB03138059XA CN100346741C (en) | 2003-05-29 | 2003-05-29 | Blood pressure measuring method and device based on heart sound signal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB03138059XA CN100346741C (en) | 2003-05-29 | 2003-05-29 | Blood pressure measuring method and device based on heart sound signal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1552282A true CN1552282A (en) | 2004-12-08 |
| CN100346741C CN100346741C (en) | 2007-11-07 |
Family
ID=34323642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB03138059XA Expired - Fee Related CN100346741C (en) | 2003-05-29 | 2003-05-29 | Blood pressure measuring method and device based on heart sound signal |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100346741C (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102525546A (en) * | 2012-01-09 | 2012-07-04 | 南京邮电大学 | Heart sound acquisition device based on photoelectric displacement sensor |
| CN102727192A (en) * | 2012-06-21 | 2012-10-17 | 大连理工大学 | Pulmonary circulation blood pressure monitoring equipment based on body surface phonocardiogram and method for monitoring pulmonary circulation blood pressure by using equipment |
| CN102791192A (en) * | 2009-10-29 | 2012-11-21 | Cn体系药物技术有限公司 | Apparatus and methods for enhancing and analyzing signals from a continous non-invasive blood pressure device |
| CN105792864A (en) * | 2013-09-20 | 2016-07-20 | 柏林心脏有限公司 | Blood pump control system and method for controlling a blood pump |
| CN106580276A (en) * | 2016-12-16 | 2017-04-26 | 天津工业大学 | Pulse wave conduction time acquisition method based on correlation |
| CN107348953A (en) * | 2017-08-10 | 2017-11-17 | 上海理工大学 | Pulse array mixed mode blood pressure monitor system |
| CN107736883A (en) * | 2017-10-24 | 2018-02-27 | 京东方科技集团股份有限公司 | Blood pressure measuring method and device |
| CN113171069A (en) * | 2021-03-05 | 2021-07-27 | 上海立阖泰医疗科技有限公司 | Embedded graphic blood pressure measuring system |
| CN113796888A (en) * | 2021-08-20 | 2021-12-17 | 雄志医疗设备科技(苏州)有限公司 | Detection method and device based on mechanical heart valve sound and readable storage medium |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1121798A (en) * | 1994-08-16 | 1996-05-08 | 北京工业大学 | Cardiovascular function dynamic parameter testing analysis method and apparatus |
| CN1127939C (en) * | 1995-07-28 | 2003-11-19 | 北京新兴生物医学工程研究发展中心 | Method for measuring arterial blood pressure by using pulse wave and apparatus thereof |
| JP3829220B2 (en) * | 1997-10-09 | 2006-10-04 | オムロンヘルスケア株式会社 | Cardiac function monitoring device |
| US6368283B1 (en) * | 2000-09-08 | 2002-04-09 | Institut De Recherches Cliniques De Montreal | Method and apparatus for estimating systolic and mean pulmonary artery pressures of a patient |
-
2003
- 2003-05-29 CN CNB03138059XA patent/CN100346741C/en not_active Expired - Fee Related
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102791192A (en) * | 2009-10-29 | 2012-11-21 | Cn体系药物技术有限公司 | Apparatus and methods for enhancing and analyzing signals from a continous non-invasive blood pressure device |
| CN102791192B (en) * | 2009-10-29 | 2015-02-25 | Cn体系药物技术有限公司 | Apparatusfor enhancing and analyzing signals from a continuous non-invasive blood pressure device |
| CN102525546A (en) * | 2012-01-09 | 2012-07-04 | 南京邮电大学 | Heart sound acquisition device based on photoelectric displacement sensor |
| CN102525546B (en) * | 2012-01-09 | 2013-07-03 | 南京邮电大学 | Heart sound acquisition device based on photoelectric displacement sensor |
| CN102727192A (en) * | 2012-06-21 | 2012-10-17 | 大连理工大学 | Pulmonary circulation blood pressure monitoring equipment based on body surface phonocardiogram and method for monitoring pulmonary circulation blood pressure by using equipment |
| US10080830B2 (en) | 2013-09-20 | 2018-09-25 | Berlin Heart Gmbh | Blood pump control system and method for controlling a blood pump |
| CN105792864A (en) * | 2013-09-20 | 2016-07-20 | 柏林心脏有限公司 | Blood pump control system and method for controlling a blood pump |
| US11420041B2 (en) | 2013-09-20 | 2022-08-23 | Berlin Heart Gmbh | Blood pump control system and method for controlling a blood pump |
| CN106580276A (en) * | 2016-12-16 | 2017-04-26 | 天津工业大学 | Pulse wave conduction time acquisition method based on correlation |
| CN107348953A (en) * | 2017-08-10 | 2017-11-17 | 上海理工大学 | Pulse array mixed mode blood pressure monitor system |
| CN107736883A (en) * | 2017-10-24 | 2018-02-27 | 京东方科技集团股份有限公司 | Blood pressure measuring method and device |
| CN113171069A (en) * | 2021-03-05 | 2021-07-27 | 上海立阖泰医疗科技有限公司 | Embedded graphic blood pressure measuring system |
| CN113171069B (en) * | 2021-03-05 | 2024-01-26 | 上海立阖泰医疗科技有限公司 | Embedded graphic blood pressure measurement system |
| CN113796888A (en) * | 2021-08-20 | 2021-12-17 | 雄志医疗设备科技(苏州)有限公司 | Detection method and device based on mechanical heart valve sound and readable storage medium |
| CN113796888B (en) * | 2021-08-20 | 2024-04-12 | 雄志医疗设备科技(苏州)有限公司 | Method and device for detecting sound based on mechanical heart valve and readable storage medium |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100346741C (en) | 2007-11-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100346740C (en) | Blood pressure measuring device and method based on the pulse information of radial artery | |
| CN107865647B (en) | Blood pressure detection device and method for calibrating blood pressure detection device | |
| US5913826A (en) | Wideband external pulse cardiac monitor | |
| US8574161B2 (en) | Vital sign monitor for cufflessly measuring blood pressure using a pulse transit time corrected for vascular index | |
| EP1332715A2 (en) | Arteriosclerosis inspecting apparatus | |
| TW200843697A (en) | Arterial blood pressure monitor with a liquid filled cuff | |
| CN100584276C (en) | Electronic auscultation apparatus | |
| US20010012916A1 (en) | Blood pressure measuring device | |
| CN1320411A (en) | Non-wound method and device for measuring blood pressure | |
| CA2326740A1 (en) | Method and apparatus for determining cardiac output or total peripheral resistance | |
| CN103648376B (en) | Lossless blood pressure monitor system | |
| US20120157791A1 (en) | Adaptive time domain filtering for improved blood pressure estimation | |
| US20140128754A1 (en) | Multimodal physiological sensing for wearable devices or mobile devices | |
| US20020052554A1 (en) | Automatic blood-pressure measuring apparatus | |
| CN107233108A (en) | A kind of wearable sticker of acquisition volume message number | |
| CN110301906A (en) | Device for non-invasively measuring blood pressure | |
| CN100346741C (en) | Blood pressure measuring method and device based on heart sound signal | |
| US6565515B2 (en) | Pulse-wave-propagation-velocity-relating-information obtaining apparatus and blood-pressure-index measuring apparatus | |
| CN1762300A (en) | Human body physiological parameter monitor device based on high frequency light capacity trace signal | |
| CN101664307A (en) | Acquisition and processing method for measuring kororkoff sound information of blood pressure with auscultatory method and device | |
| CN112890790A (en) | Wearable noninvasive dynamic blood pressure tracking and monitoring method | |
| CN111449637A (en) | Evaluation system and method for arteriovenous internal fistula blood vessel | |
| WO2012145938A1 (en) | Piezoelectric blood-pressure sensor | |
| CN105167764A (en) | Blood pressure measuring device and method | |
| CN1582845A (en) | Blood pressure measuring method based on photoelectric plethysmographic signals with temperature compensation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20071107 Termination date: 20120529 |