CN117338254B - Alveolar water oxygen content monitoring system based on tracheal catheter photoacoustic imaging - Google Patents
Alveolar water oxygen content monitoring system based on tracheal catheter photoacoustic imaging Download PDFInfo
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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Abstract
The invention provides an alveolar water oxygen content monitoring system based on optoacoustic imaging of an endotracheal tube, which relates to the technical field of medical monitoring, and combines optoacoustic imaging with the endotracheal tube to be applied to alveolar water oxygen content monitoring of a patient, wherein micro-ring resonant cavity monomers are adopted for sensing detection in optoacoustic imaging, and compared with a micro-cavity array, the system has the advantages of small occupied space, high integration of the integral application of the endotracheal tube and high sensitivity; the scanning galvanometer in the water-oxygen detection probe is adopted to carry out two-dimensional scanning focusing, the focusing light spots traverse the scanning alveoli point by point, the alveoli image is directly reconstructed, the real-time performance is good, the result is accurate, the reconstruction of the image by a reconstruction algorithm is not needed, the accurate guidance of the alveoli position is conveniently provided for clinical monitoring of the pulmonary bubble water-oxygen content distribution, the alveoli water content and the blood oxygen content are obtained by combining the alveoli image on the basis of obtaining the alveoli water content and the blood oxygen content, and the method has great guidance significance for clinical monitoring of patients with pulmonary diseases.
Description
Technical Field
The invention relates to the technical field of medical monitoring, in particular to an alveolar water oxygen content monitoring system based on optoacoustic imaging of an endotracheal tube.
Background
The tracheal catheter is required to be used in patients with general anesthesia and serious respiratory tract infection and any patients needing respiratory auxiliary treatment, and is an essential pipeline for ensuring pulmonary ventilation and ventilation. If the water content or the oxygen content of the alveoli can be detected while the tracheal catheter is used, the method has great guiding significance for clinical monitoring of patients with pulmonary diseases.
The photoacoustic imaging is a novel nondestructive marking-free medical imaging method based on optical excitation and acoustic detection, integrates the characteristics of high resolution of optical imaging and high penetration depth of acoustic imaging, and provides a powerful and effective technical means for monitoring physiological and pathological processes inside tissues and diagnosing related diseases. The scheme adopts a flexible microcavity sensing array as a sensing detection unit, utilizes a light source generating device to output a light source, reflects the light source through a reflecting mirror and expands the beam by a beam expander, then makes the light source enter a target to be detected in a box body, absorbs light energy to thermally expand to generate instantaneous ultrasonic pulses due to the photoacoustic effect, then transmits the instantaneous ultrasonic pulses to the sensing detection unit to convert the instantaneous ultrasonic pulses into optical signals, demodulates the optical signals into electric signals, transmits the electric signal data to control imaging processing equipment to complete signal acquisition, and finally performs image reconstruction.
However, when the patient uses the tracheal catheter, if the water content or the blood oxygen content of the alveoli of the patient is to be detected at the same time, the photoacoustic imaging in the mode is required to be combined with the tracheal catheter, and the combination with the photoacoustic imaging is required to be considered when the tracheal catheter is connected with the breathing machine, on one hand, the current photoacoustic imaging system adopts a flexible microcavity sensing array, the microcavity array occupies a large space, so that the integrated level of the whole application of the tracheal catheter is low, and the array matching sensitivity is poor; on the other hand, the real-time rapid and accurate reconstruction of the alveolar images at different positions is the basis for monitoring the pulmonary bubble water oxygen content distribution of a patient, the water oxygen content distribution of different pulmonary alveoli of the patient can be known in an assisted clinical mode according to the displayed positions of the alveolar images, and the method has great guiding significance for clinical monitoring of the pulmonary alveoli of the patient.
Disclosure of Invention
In order to solve the problem that the prior art cannot accurately monitor the distribution of the pulmonary bubble water and oxygen content, the invention provides an alveolar water and oxygen content monitoring system based on the optoacoustic imaging of an endotracheal tube, which is matched with the endotracheal tube well, has high sensitivity, assists in clinically knowing the water and oxygen content distribution of different alveolus positions of a patient, and has great development prospects in optoacoustic water and oxygen detection and imaging.
In order to achieve the technical effects, the technical scheme of the invention is as follows:
an alveolar water oxygen content monitoring system based on endotracheal tube photoacoustic imaging, comprising:
the short pulse laser generator is used for outputting a short pulse laser light source;
one end of the water-oxygen detection probe is used for receiving the short pulse laser light source, and the other end of the water-oxygen detection probe is connected with the medical breathing machine through an endotracheal tube; the water oxygen detection probe is internally provided with a reflecting prism, a scanning galvanometer, a focusing lens and a microcavity sensing part, a short pulse laser light source is reflected to the scanning galvanometer by the reflecting prism, and is focused by the focusing lens after passing through the two-dimensional scanning of the scanning galvanometer, and then is incident to an alveolus to be detected, and the alveolus to be detected absorbs light energy to generate an ultrasonic pulse signal; the micro-cavity sensing part comprises a micro-ring resonant cavity monomer and a pulley waveguide coupled with the micro-ring resonant cavity monomer, and an ultrasonic pulse signal is detected by the micro-ring resonant cavity monomer and converted into an optical signal;
one end of the tracheal catheter is connected with the water oxygen detection probe, and the other end of the tracheal catheter is connected with the medical breathing machine;
the signal converter is used for receiving the optical signal and converting the optical signal into an electric signal;
the water-oxygen control analyzer is used for receiving the electric signals transmitted by the signal converter, reconstructing an alveolar image, analyzing the alveolar water-oxygen content of different alveolar positions, and combining the alveolar images to obtain the alveolar water-oxygen content distribution of different alveolar positions, wherein the alveolar water-oxygen content comprises water content and blood oxygen content.
Preferably, the wavelength of the short pulse laser light source is tunable so as to specifically excite and detect oxygen molecules and water molecules.
Preferably, the microcavity sensing part is positioned at one side of the reflecting prism, the sensing surface of the micro-ring resonant cavity monomer is opposite to the alveoli to be detected, one end of the pulley waveguide is connected with a signal light input optical fiber, and the other end of the pulley waveguide is connected with a signal light output optical fiber; the alveoli absorb light energy to generate ultrasonic pulse signals, the ultrasonic pulse signals are input from a signal light input optical fiber and transmitted into a micro-ring resonant cavity monomer through a pulley waveguide, the micro-ring resonant cavity monomer collects the ultrasonic signals and converts the ultrasonic signals into optical signals, the optical signals are coupled to the pulley waveguide and output to a signal converter through a signal light output optical fiber, and the signal converter converts the optical signals into electric signal sampling data.
Through the technical means, the micro-ring resonant cavity monomer is adopted in the water-oxygen detection probe, the sensing surface of the micro-ring resonant cavity monomer is opposite to the alveoli to be detected, so that ultrasonic signals excited by the alveoli to be detected can be conveniently received.
Preferably, the signal converter converts the optical signal based on a wavelength locking method of a resonance peak of a micro-ring resonant cavity monomer, so that the conversion speed is improved, and the conversion cost can be reduced.
Preferably, the alveolar water oxygen content monitoring system based on tracheal catheter photoacoustic imaging further comprises: the air bag and the needle tube are arranged in the air bag, and the needle tube is connected with the air bag through a pipeline to inflate the air bag so as to fix the air pipe.
Preferably, the water-oxygen control analyzer is connected with the short pulse laser generator and controls the wavelength, the power and the pulse frequency of the short pulse laser source output by the short pulse laser generator.
Preferably, the water-oxygen control analyzer is further connected with a water-oxygen detection probe, and controls the movement of the water-oxygen detection probe.
Preferably, the water-oxygen detection probe moves to drive the scanning galvanometer in the water-oxygen detection probe to move, the short pulse laser light source is reflected to the scanning galvanometer by the reflecting prism, the scanning galvanometer is subjected to two-dimensional scanning, the positions of the short pulse laser light source, which are incident to alveoli to be detected, are different after being focused by the focusing lens, the focusing light spots traverse the scanning alveoli point by point to reconstruct alveoli images at different alveoli positions, in the process of reconstructing the alveoli images, the different positions of alveoli are traversed, ultrasonic pulse signals generated by the absorption light energy of the alveoli are obtained, and finally, the electric signal sampling data at the different alveoli positions are obtained.
Through the technical means, the scanning galvanometer in the water-oxygen detection probe is adopted to perform two-dimensional scanning focusing, the focusing light spots traverse the scanning alveoli point by point, the alveoli image is directly reconstructed, the real-time performance is poor, the image reconstruction is accurate, the reconstruction algorithm is not needed, and the guidance of the accurate alveoli position is conveniently provided for clinical monitoring of the lung bubble water-oxygen content distribution.
Preferably, during water content analysis, a short pulse laser generator sends out a short pulse laser light source with wavelength matching with a water absorption peak, electric signal sampling data of different alveolus positions are finally obtained, the larger the electric signal sampling data is, the higher the alveolar water content is, and the alveolar water content distribution of different alveolus positions is obtained by combining an alveolar image;
preferably, in the blood oxygen content analysis, the short pulse laser generator emits two wavelengths of short pulse laser sources, and the excitation light intensities of the two wavelengths of short pulse laser sources are respectivelyI 1 AndI 2 the light and sound signal intensity of the excitation is respectively:
wherein,and->Respectively representing the intensity of photoacoustic signals corresponding to the two wavelengths, < ->And->Respectively representing absorption coefficients of the aerobic hemoglobin corresponding to two wavelengths excited by the short pulse laser light source; />And->Respectively representing the absorption coefficients of a certain position of the alveoli under two wavelengths excited by a short pulse laser light source; />Represents the concentration of oxyhemoglobin; />Represents the concentration of anaerobic hemoglobin; the blood oxygen content at a certain position of the alveoli is:
wherein,and->Respectively representing absorption coefficients of the anaerobic hemoglobin corresponding to two wavelengths excited by a short pulse laser light source; />And->Respectively representing the difference of absorption coefficients of the aerobic hemoglobin and the anaerobic hemoglobin corresponding to two wavelengths excited by the short pulse laser light source, and combining the alveolar images to obtain alveolar blood oxygen content distribution of different alveolar positions.
By the technical means, on the basis of acquiring the alveolar water content and the blood oxygen content, the alveolar water content and the blood oxygen content distribution of different alveolar positions are obtained by combining the alveolar images, so that the method has great guiding significance for clinical monitoring of patients suffering from pulmonary diseases.
Compared with the prior art, the technical scheme of the invention has the beneficial effects that:
the invention provides an alveolar water oxygen content monitoring system based on optoacoustic imaging of an endotracheal tube, which combines optoacoustic imaging with the endotracheal tube and is applied to alveolar water oxygen content monitoring of a patient, wherein micro-ring resonant cavity monomers are adopted for sensing detection in the optoacoustic imaging, and compared with micro-cavity arrays, the system has small occupied space, high integration of the integral application of the endotracheal tube, no need of sensing cooperation of all micro-cavity arrays and high sensitivity of the monomers; and the scanning galvanometer in the water-oxygen detection probe is adopted to perform two-dimensional scanning focusing, the focusing light spots traverse the scanning alveoli point by point, the alveoli image is directly reconstructed, the real-time performance is poor, the accuracy is realized, the reconstruction of the image by a reconstruction algorithm is not needed, the accurate guidance of the alveoli position is conveniently provided for clinical monitoring of the pulmonary bubble water-oxygen content distribution, the alveoli water content and the blood oxygen content are obtained by combining the alveoli image on the basis of obtaining the alveolar water content and the blood oxygen content, and the method has great guidance significance for clinical monitoring of patients with pulmonary diseases.
Drawings
FIG. 1 shows a block diagram of an alveolar water oxygen content monitoring system based on optoacoustic imaging of an endotracheal tube according to an embodiment of the present invention;
FIG. 2 is a schematic diagram showing the basic constitution of the internal structure of the water-oxygen detecting probe according to the embodiment of the present invention;
fig. 3 shows a schematic diagram of a microcavity sensor according to an embodiment of the present invention.
Detailed Description
The drawings are for illustrative purposes only and are not to be construed as limiting the present patent;
for better illustration of the present embodiment, some parts of the drawings may be omitted, enlarged or reduced, and do not represent actual dimensions;
it will be appreciated by those skilled in the art that some well known descriptions in the figures may be omitted.
The technical scheme of the invention is further described below with reference to the accompanying drawings and examples.
The positional relationship depicted in the drawings is for illustrative purposes only and is not to be construed as limiting the present patent;
example 1
As shown in fig. 1, this embodiment proposes an alveolar water oxygen content monitoring system based on optoacoustic imaging of an endotracheal tube, including: the device comprises a short pulse laser generator 1, a water and oxygen detection probe 2, an air pipe conduit 3, a signal converter 4 and a water and oxygen control analyzer 5, wherein the short pulse laser generator 1 is used for outputting a short pulse laser light source, and in the embodiment, the wavelength of the short pulse laser light source is tunable so as to specifically excite and detect oxygen molecules and water molecules. One end of the water and oxygen detection probe 2 is used for receiving a short pulse laser light source, the other end is connected with a medical breathing machine through an endotracheal tube 3, see fig. 1, and the alveolar water and oxygen content monitoring system based on the optoacoustic imaging of the endotracheal tube further comprises: the air sac 6 and the needle tube 7 are arranged in the air sac 6, the needle tube 7 is connected with the air sac 6 through a pipeline to inflate the air sac 6 so as to fix the air sac 3, the signal converter 4 is used for receiving optical signals and converting the optical signals into electric signals, the water-oxygen control analyzer 5 is used for receiving the electric signals transmitted by the signal converter 4, reconstructing an alveolar image and analyzing the alveolar water-oxygen contents of different alveolar positions, and the alveolar water-oxygen content distribution of different alveolar positions is obtained by combining the alveolar images, wherein the alveolar water-oxygen contents comprise water content and blood-oxygen content.
Referring to fig. 1, a short pulse laser generator 1 is connected in parallel with a catheter 3 through an excitation optical fiber 20 and is connected to one end of a water oxygen detection probe 2, the short pulse laser generator 1 outputs a light source, the light source is transmitted to the water oxygen detection probe 2 at the tail end of the catheter through the excitation optical fiber 20, as shown in fig. 2, a reflecting prism 21, a scanning galvanometer 22, a focusing lens 23 and a microcavity sensing part 24 are arranged in the water oxygen detection probe 2, the short pulse laser light source is transmitted to the water oxygen detection probe 2 through the excitation optical fiber 20, the light source is reflected to the scanning galvanometer 22 by the reflecting prism 21, and the light source is focused by the focusing lens 23 after being scanned by two-dimension scanning galvanometer 22, and then is incident to alveoli to be detected, and the alveoli to be detected absorbs light energy to generate ultrasonic pulse signals.
Referring to fig. 3, the microcavity sensing portion 24 includes a micro-ring resonator monomer 241 and a pulley waveguide 242 coupled to the micro-ring resonator monomer (241), and an ultrasonic pulse signal is detected by the micro-ring resonator monomer 241 and converted into an optical signal; the microcavity sensing part 24 is positioned at one side of the reflecting prism 21, the sensing surface of the micro-ring resonant cavity monomer 241 is opposite to the alveoli to be detected, one end of the pulley waveguide 242 is connected with the signal light input optical fiber 25, and the other end is connected with the signal light output optical fiber 26; the alveoli absorb light energy to generate ultrasonic pulse signals, the ultrasonic pulse signals are input from the signal light input optical fiber 25, transmitted into the micro-ring resonant cavity monomer 241 through the pulley waveguide 242, the micro-ring resonant cavity monomer 241 collects ultrasonic signals and converts the ultrasonic signals into optical signals, the optical signals are coupled to the pulley waveguide 242 and output to the signal converter 4 through the signal light output optical fiber 26, the signal converter 4 converts the optical signals into electrical signal sampling data, the water-oxygen control analyzer 5 receives the electrical signal sampling data, and reconstruction of an alveoli image and analysis of water content and blood oxygen content are completed.
In this embodiment, the light source output by the short pulse laser generator has a certain wavelength, and the light source is focused and then is incident on the alveoli to be detected, and the ultrasonic pulse signal excited by the alveoli to be detected is received and detected by the microcavity sensing portion 24 in the water-oxygen detecting probe 2. As shown in fig. 3, the micro-ring resonator monomer 241 in the micro-cavity sensing portion 24 has a radius R, and is coupled to the pulley waveguide 242 with a coupling pitch G; the micro-ring resonant cavity monomer 241 and the pulley waveguide 252 are made of a chalcogenide material, the top of the micro-ring resonant cavity monomer 241 and the pulley waveguide 252 are wrapped by a polymer material, the bottom is adsorbed on a substrate material, and the substrate material is made of a silicon material.
The size of the micro-ring resonant cavity monomer 241 can be adjusted according to the requirement in the processing process of the micro-cavity sensing part 24 so as to adapt to different imaging receiving angles, the micro-ring resonant cavity monomer 241 in the micro-cavity sensing part 24 is coupled with the pulley waveguide 242, the pulley waveguide 242 transmits the signal light in the signal light input optical fiber 25 into the micro-ring resonant cavity monomer 241, and then the optical signal with ultrasonic information is coupled to the pulley waveguide 242 again and finally output by the signal light output optical fiber 26. The pulley coupling mode is used for ensuring that only one polarization mode exists in the coupling process of the micro-ring resonant cavity monomer 241 and the pulley waveguide 242, so that subsequent signal conversion is facilitated, ultrasonic pulse signals are generated by alveoli to be detected, a time sequence ultrasonic signal is acquired by the micro-ring resonant cavity monomer 241 of the micro-cavity sensing part 24, the optical signals are converted into electrical signal sampling data by the signal converter 4, the electrical signal sampling data is received by the water-oxygen control analyzer 5, and reconstruction of an alveolar image is completed. In the specific implementation, the radius R of the micro-ring resonant cavity monomer 241 can be adjusted according to the requirement, and the coupling distance G of the micro-ring resonant cavity monomer 241 is not limited to a circle, but also can be spherical or square, so that the flexibility is strong, and the sensitivity and the maximum detectable angle of sensing are changed by designing different main frequencies and direction angles, so as to adapt to different imaging resolutions and imaging depths.
When the micro-ring is disturbed by external pressure, the refractive index change of the micro-ring is caused, the wavelength of the resonance peak of the micro-ring is shifted, and the time domain response of the ultrasonic signal can be restored by measuring the power change or the shift amount of the resonance peak at the maximum slope of the resonance peak.
In the embodiment, the micro-ring resonant cavity monomer 241 is adopted in the water-oxygen detection probe, the sensing surface of the micro-ring resonant cavity monomer 241 is opposite to the alveoli to be detected, so that ultrasonic signals excited by the alveoli to be detected can be conveniently received.
In the present embodiment, the signal converter 4 converts an optical signal based on a wavelength locking method of a resonance peak of the micro-ring resonator monomer 241.
Example 2
In this embodiment, the water-oxygen control analyzer 5 is further described, and as shown in fig. 1, the water-oxygen control analyzer 5 is connected to the short pulse laser generator 1, and controls the wavelength, power and pulse frequency of the short pulse laser light source output from the short pulse laser generator 1.
The water-oxygen control analyzer 5 is also connected with the water-oxygen detection probe 2, and controls the movement of the water-oxygen detection probe 2, thereby controlling the scanning position of the water-oxygen detection probe 3 and the corresponding alveolar imaging position.
In this embodiment, the water-oxygen detecting probe 2 is provided with a protective housing, the protective housing is of a closed structure, the interior of the protective housing is filled with water or ultrasonic coupling glue, and a transparent window at the top end of the water-oxygen detecting probe 2 is attached to an alveolus to be detected, so that an echo ultrasonic signal can be better received. The alveoli to be tested excite transient ultrasonic signals due to the photoacoustic effect and transmit the ultrasonic signals by taking water as a transmission medium, and in addition, the alveoli to be tested comprise but are not limited to biological pulmonary capillaries, pulmonary arteriovenous and deep tissues.
In the specific implementation, the water-oxygen detection probe 2 moves to drive the scanning galvanometer 22 in the water-oxygen detection probe 2 to move, the short pulse laser light source is reflected to the scanning galvanometer 22 by the reflecting prism 21, after being subjected to two-dimensional scanning by the scanning galvanometer 22 and then focused by the focusing lens 23, the short pulse laser light source is incident to different positions of alveoli to be detected, the focusing light spots traverse the scanning alveoli point by point to reconstruct alveoli images at different alveoli positions, in the process of reconstructing the alveoli images, the different positions of alveoli are traversed, ultrasonic pulse signals generated by light energy absorbed by the alveoli are obtained, and finally electric signal sampling data at different alveoli positions are obtained.
The scanning galvanometer in the water-oxygen detection probe is adopted to carry out two-dimensional scanning focusing, the focusing light spots traverse the scanning alveoli point by point, the alveoli image is directly reconstructed, the real-time performance is poor, the image reconstruction is accurate, the reconstruction algorithm is not needed, and the guidance of the accurate alveoli position is conveniently provided for clinical monitoring of the lung bubble water-oxygen content distribution.
Example 3
When the water content analysis is carried out by the water-oxygen control analyzer 5, the short pulse laser generator 1 sends out a short pulse laser light source with wavelength matching with the water absorption peak, and finally electric signal sampling data of different alveolus positions are obtained, the larger the electric signal sampling data is, the higher the alveolar water content is, and the alveolar water content distribution of different alveolus positions is obtained by combining an alveolar image.
When the water-oxygen control analyzer 5 performs blood oxygen content analysis, the short pulse laser generator 1 emits two short pulse laser sources with two wavelengths, and the excitation light intensities excited by the two short pulse laser sources are respectivelyI 1 AndI 2 the light and sound signal intensity of the excitation is respectively that the water and oxygen detection probe 2 is incident to a certain position of the alveoli:
wherein,and->Respectively representing the intensity of photoacoustic signals corresponding to the two wavelengths, < ->And->Respectively indicate that the aerobic hemoglobin is shortAbsorption coefficients corresponding to two wavelengths excited by a pulse laser light source; />And->Respectively representing the absorption coefficients of a certain position of the alveoli under two wavelengths excited by a short pulse laser light source; />Represents the concentration of oxyhemoglobin; />Represents the concentration of anaerobic hemoglobin; the blood oxygen content at a certain position of the alveoli is:
wherein,and->Respectively representing absorption coefficients of the anaerobic hemoglobin corresponding to two wavelengths excited by a short pulse laser light source; />And->Respectively representing the difference of absorption coefficients of the aerobic hemoglobin and the anaerobic hemoglobin corresponding to two wavelengths excited by the short pulse laser light source, and combining the alveolar images to obtain alveolar blood oxygen content distribution of different alveolar positions.
On the basis of acquiring the alveolar water content and the blood oxygen content, the alveolar water content and the blood oxygen content distribution of different alveolar positions are acquired by combining the alveolar images, and the method has great guiding significance for clinical monitoring of patients suffering from pulmonary diseases.
It is to be understood that the above examples of the present invention are provided by way of illustration only and are not intended to limit the scope of the invention. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor is it exhaustive of all embodiments. Any modification, equivalent replacement, improvement, etc. which come within the spirit and principles of the invention are desired to be protected by the following claims.
Claims (10)
1. An alveolar water oxygen content monitoring system based on endotracheal tube photoacoustic imaging, comprising:
a short pulse laser generator (1) for outputting a short pulse laser light source;
one end of the water-oxygen detection probe (2) is used for receiving the short pulse laser light source, and the other end is connected with the medical breathing machine through the tracheal catheter (3); the water oxygen detection probe (2) is internally provided with a reflecting prism (21), a scanning galvanometer (22), a focusing lens (23) and a microcavity sensing part (24), a short pulse laser light source is reflected to the scanning galvanometer (22) by the reflecting prism (21), and after being focused by the focusing lens (23), the short pulse laser light source is incident to an alveolus to be detected, and the alveolus to be detected absorbs light energy to generate an ultrasonic pulse signal; the microcavity sensing part (24) comprises a micro-ring resonant cavity monomer (241) and a pulley waveguide (242) coupled with the micro-ring resonant cavity monomer (241), and an ultrasonic pulse signal is detected by the micro-ring resonant cavity monomer (241) and converted into an optical signal;
an air pipe conduit (3), one end of which is connected with a water oxygen detection probe (2) and the other end of which is connected with a medical breathing machine;
a signal converter (4) for receiving an optical signal and converting the optical signal into an electrical signal;
and the water-oxygen control analyzer (5) is used for receiving the electric signals transmitted by the signal converter (4), reconstructing an alveolar image, analyzing the alveolar water-oxygen content of different alveolar positions, and combining the alveolar images to obtain the alveolar water-oxygen content distribution of the different alveolar positions, wherein the alveolar water-oxygen content comprises water content and blood oxygen content.
2. The endotracheal tube photoacoustic imaging-based alveolar water oxygen content monitoring system of claim 1, wherein the wavelength of the short pulse laser light source is tunable.
3. The alveolar water oxygen content monitoring system based on tracheal catheter photoacoustic imaging according to claim 1, wherein the microcavity sensing part (24) is positioned at one side of the reflecting prism (21), the sensing surface of the micro-ring resonant cavity monomer (241) is opposite to the alveoli to be detected, one end of the pulley waveguide (242) is connected with a signal light input optical fiber (25), and the other end is connected with a signal light output optical fiber (26); the alveoli absorb light energy to generate ultrasonic pulse signals, the ultrasonic pulse signals are input from a signal light input optical fiber (25), are transmitted into a micro-ring resonant cavity monomer (241) through a pulley waveguide (242), the micro-ring resonant cavity monomer (241) collects ultrasonic signals and converts the ultrasonic signals into optical signals, the optical signals are coupled to the pulley waveguide (242), and are output to a signal converter (4) through a signal light output optical fiber (26), and the signal converter (4) converts the optical signals into electrical signal sampling data.
4. An alveolar water oxygen content monitoring system based on optoacoustic imaging of an endotracheal tube according to claim 3, wherein the signal converter (4) converts the optical signal based on a wavelength locking method of resonance peaks of micro-ring resonator monomers (241).
5. The endotracheal tube photoacoustic imaging-based alveolar water oxygen content monitoring system of claim 1, further comprising: the tracheal catheter comprises an air bag (6) and a needle tube (7), wherein the tracheal catheter (3) is arranged in the air bag (6), the needle tube (7) is connected with the air bag (6) through a pipeline, and the air bag (6) is inflated to fix the tracheal catheter (3).
6. The alveolar water oxygen content monitoring system based on the optoacoustic imaging of the tracheal catheter according to claim 1, wherein the water oxygen control analyzer (5) is connected with the short pulse laser generator (1) and controls the wavelength, the power and the pulse frequency of the short pulse laser source output by the short pulse laser generator (1).
7. Alveolar water oxygen content monitoring system based on optoacoustic imaging of an endotracheal tube according to claim 1, wherein the water oxygen control analyzer (5) is further connected to a water oxygen detection probe (2), controlling the movement of the water oxygen detection probe (2).
8. The pulmonary alveolus water and oxygen content monitoring system based on tracheal catheter photoacoustic imaging according to claim 7, wherein the water and oxygen detection probe (2) moves to drive a scanning galvanometer (22) in the water and oxygen detection probe (2) to move, the short pulse laser light source is reflected to the scanning galvanometer (22) by a reflecting prism (21), after being focused by a focusing lens (23), the short pulse laser light source is incident to the pulmonary alveolus to be detected at different positions through two-dimensional scanning of the scanning galvanometer (22), a focusing light spot traverses the scanning pulmonary alveolus point by point to reconstruct the pulmonary alveolus images at different pulmonary alveolus positions, and in the process of reconstructing the pulmonary alveolus images, the ultrasonic pulse signals generated by the absorption of light energy by the pulmonary alveolus are traversed at different positions, and finally the electrical signal sampling data at different pulmonary alveolus positions are acquired.
9. The pulmonary alveolus water and oxygen content monitoring system based on the optoacoustic imaging of the tracheal catheter according to claim 8, wherein the short pulse laser generator (1) emits a short pulse laser light source with the wavelength matching the water absorption peak during the water content analysis, and finally obtains the electrical signal sampling data of different pulmonary alveolus positions, the greater the electrical signal sampling data is, the higher the pulmonary alveolus water content is, and the pulmonary alveolus water content distribution of different pulmonary alveolus positions is obtained by combining the pulmonary alveolus images.
10. The alveolar water oxygen content monitoring system based on the optoacoustic imaging of the tracheal catheter according to claim 8, wherein the short pulse laser generator (1) emits short pulse excitation of two wavelengths during blood oxygen content analysisThe excitation light intensities of the light source and the short pulse laser light source with two wavelengths are respectivelyI 1 AndI 2 the light and sound signals are respectively excited by the water and oxygen detection probe (2) entering a certain position of the alveoli:
wherein,and->Respectively representing the intensity of photoacoustic signals corresponding to the two wavelengths, < ->And->Respectively representing absorption coefficients of the aerobic hemoglobin corresponding to two wavelengths excited by the short pulse laser light source; />And->Respectively representing the absorption coefficients of a certain position of the alveoli under two wavelengths excited by a short pulse laser light source; />Represents the concentration of oxyhemoglobin; />Represents the concentration of anaerobic hemoglobin; thenThe blood oxygen content at a certain position of the alveoli is as follows:
wherein,and->Respectively representing absorption coefficients of the anaerobic hemoglobin corresponding to two wavelengths excited by a short pulse laser light source; />And->Respectively representing the difference of absorption coefficients of the aerobic hemoglobin and the anaerobic hemoglobin corresponding to two wavelengths excited by the short pulse laser light source, and combining the alveolar images to obtain alveolar blood oxygen content distribution of different alveolar positions.
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