CN114965118B - Subcutaneous implantation type drug administration testing device - Google Patents
Subcutaneous implantation type drug administration testing device Download PDFInfo
- Publication number
- CN114965118B CN114965118B CN202210387913.8A CN202210387913A CN114965118B CN 114965118 B CN114965118 B CN 114965118B CN 202210387913 A CN202210387913 A CN 202210387913A CN 114965118 B CN114965118 B CN 114965118B
- Authority
- CN
- China
- Prior art keywords
- axis
- puncture
- driving
- assembly
- liquid injection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N3/32—Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces
- G01N3/38—Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces generated by electromagnetic means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N3/02—Details
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N3/02—Details
- G01N3/04—Chucks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/0001—Type of application of the stress
- G01N2203/0005—Repeated or cyclic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/003—Generation of the force
- G01N2203/005—Electromagnetic means
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Electromagnetism (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses a subcutaneous implantation type drug delivery testing device which comprises a puncture assembly, a driving assembly, a fixing assembly and a liquid injection assembly, wherein the puncture assembly comprises a puncture driving piece and a puncture needle, the puncture driving piece is used for driving the puncture needle to move along the Z-axis direction, the puncture needle can rotate relative to the puncture driving piece and is matched with the puncture driving piece, the driving assembly is used for driving the puncture driving piece to move along the Y-axis and the X-axis direction, the liquid injection assembly is connected with the puncture needle so as to output liquid towards the puncture needle, the fixing assembly is positioned below the puncture assembly, and the fixing assembly is used for bearing an experimental sample. The subcutaneous implantation type drug administration testing device can flexibly control the puncture point and the puncture depth, can simulate the drug administration state of the drug administration device, and can improve the experimental precision of a puncture experiment, thereby ensuring the detection precision.
Description
Technical Field
The invention relates to the technical field of medical experimental equipment, in particular to a subcutaneous implantation type drug administration testing device.
Background
The subcutaneous implanted drug delivery device is a medical device clinically used for subcutaneous implantation of patients for long-term drug delivery, is used for local drug infusion or nutrient delivery, and can infuse drugs through a non-invasive needle for multiple times, long time and repeatedly after puncture is completed, so that the infused drugs directly reach the inside of a sheath, the dosage is reduced, toxic and side effects are lightened, and the drug treatment effect is enhanced. In use, if the subcutaneous implantable drug delivery device is punctured, debris is generated, which can follow the drug into the body, thereby affecting the therapeutic effect. Thus, it is necessary to perform a penetration test on the subcutaneous implantable drug delivery device during the manufacturing process, so as to detect the penetration limit that the subcutaneous implantable drug delivery device can withstand. At present, a quality testing device for a subcutaneous implanted drug delivery device is simple in structure, can not flexibly control a puncture point, and can not well simulate the drug delivery state of the drug delivery device during use, so that the precision of a quality testing result is poor.
Disclosure of Invention
The invention aims to provide a subcutaneous implantation type drug delivery testing device which can flexibly control puncture points and puncture depths, simulate the drug delivery state of a drug delivery device, and improve the experimental precision of a puncture experiment so as to ensure the detection precision.
In order to realize the technical scheme, the technical scheme of the invention is as follows:
the invention discloses a subcutaneous implantation type drug administration testing device, which comprises: the puncture assembly comprises a puncture driving piece and a puncture needle, wherein the puncture driving piece is used for driving the puncture needle to move along the Z-axis direction, and the puncture needle can rotate relative to the puncture driving piece; the driving assembly is matched with the puncture driving piece and used for driving the puncture driving piece to move along the Y-axis and the X-axis; the liquid injection assembly is connected with the puncture needle so as to output liquid towards the puncture needle; the fixed subassembly, fixed subassembly is located puncture subassembly below, fixed subassembly is used for bearing experimental sample.
In some embodiments, the drive assembly comprises: the X-axis driving group is connected with the puncture driving piece to drive the puncture driving piece to move along the X-axis direction; and the Y-axis driving group is connected with the X-axis driving group to drive the X-axis driving group to move along the Y-axis direction.
In some specific embodiments, the X-axis drive group comprises: the X-axis fixing seat is connected with the Y-axis driving group; the X-axis driving source is arranged on the X-axis fixing seat; the X-axis sliding block is connected with the X-axis driving source and slides relative to the X-axis fixing seat under the driving of the X-axis driving source, and the X-axis sliding block is connected with the puncture driving piece.
In some specific embodiments, the Y-axis drive-group comprises: a Y-axis fixing seat; the Y-axis driving source is arranged on the Y-axis fixing seat; the Y-axis sliding block is connected with the Y-axis driving source and slides relative to the Y-axis fixing seat under the driving of the Y-axis driving source, and the Y-axis sliding block is connected with the X-axis driving group.
In some more specific embodiments, the number of the Y-axis sliding blocks is two, and the two Y-axis sliding blocks are respectively connected to two ends of the X-axis driving group.
In some embodiments, the securing assembly comprises: a water bath tank; the fixing box is arranged inside the water bath box, and the experimental sample is arranged in the fixing box; the water pump is arranged in the water bath box or the fixed box, so that liquid in the water bath box is output to the fixed box.
In some specific embodiments, a fixture is provided in the fixing box, the fixture is used for clamping the experimental sample, and the fixture includes: the fixed base is arranged on the bottom wall of the fixed box; the movable seat is arranged at intervals with the fixed base, and an exposure hole is formed in the movable seat; one end of the adjusting bolt is connected with the fixed base, and the other end of the adjusting bolt is arranged on the movable base in a penetrating way; the adjusting nut is matched with the adjusting bolt and is stopped against the movable seat.
In some embodiments, the priming assembly comprises: a liquid injection fixing seat; the liquid injection driving piece is arranged on the liquid injection fixing seat; the liquid injection needle cylinder is fixed on the liquid injection fixing seat, an injection piston of the liquid injection needle cylinder is connected with the liquid injection driving piece, and a liquid injection hole of the liquid injection needle cylinder is connected with the puncture needle through a liquid outlet pipeline.
In some specific embodiments, the priming assembly further comprises: the liquid inlet pipeline is connected with an external liquid source and the liquid injection hole; the one-way valve is arranged on the liquid inlet pipeline and the liquid outlet pipeline.
In some embodiments, the subcutaneously implantable drug delivery testing device further comprises a manipulator juxtaposed with the spike for mounting the spike to the spike drive or removing the spike from the spike drive.
The subcutaneous implantation type drug administration testing device has the beneficial effects that: the puncture driving piece can drive the puncture needle to move along the Z-axis direction, so that the function of precisely controlling the puncture depth of the puncture needle is realized. The driving component can drive the puncture needle to move along the Y-axis direction and the X-axis direction, so that the function of precisely controlling the puncture position of the puncture needle is realized. The liquid injection assembly can simulate the state of an experimental sample in the actual process on one hand, so that the accuracy is improved; on the other hand, if the experimental sample has chips, the chips can be flushed out by the injected liquid, so that the experimental sample can be conveniently observed by experimental staff.
Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.
Drawings
FIG. 1 is a schematic diagram of a subcutaneously implantable drug delivery testing device according to an embodiment of the present invention;
FIG. 2 is a schematic view showing a partial structure of a subcutaneously implantable drug delivery test device according to an embodiment of the present invention;
fig. 3 is a schematic structural view of a fixing jig according to an embodiment of the present invention.
Reference numerals:
1. a puncture assembly; 11. a puncture driving member; 12. a puncture needle;
2. a drive assembly; 21. an X-axis driving group; 211. an X-axis fixing seat; 212. an X-axis driving source; 213. an X-axis sliding block; 22. a Y-axis driving group; 221. a Y-axis fixing seat; 222. a Y-axis driving source; 223. a Y-axis sliding block;
3. a fixing assembly; 31. a water bath tank; 32. a fixed box;
4. a liquid injection assembly; 41. a liquid injection fixing seat; 42. a liquid injection driving member; 43. a liquid injection needle cylinder;
5. a fixing clamp; 51. a fixed base; 52. a movable seat; 53. an adjusting bolt; 54. an adjusting nut;
6. and a control system.
Detailed Description
In order to make the technical problems solved, the technical scheme adopted and the technical effects achieved by the invention more clear, the technical scheme of the invention is further described below by a specific embodiment in combination with the attached drawings.
In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element being referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present invention.
Furthermore, features defining "first", "second" may include one or more such features, either explicitly or implicitly, for distinguishing between the descriptive features, and not sequentially, and not lightly. In the description of the present invention, unless otherwise indicated, the meaning of "a plurality" is two or more.
In the description of the present invention, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
The following describes the specific structure of a subcutaneously implantable drug delivery test device according to an embodiment of the present invention with reference to fig. 1 to 3.
The invention discloses a subcutaneous implantation type drug delivery testing device, as shown in fig. 1, the subcutaneous implantation type drug delivery testing device of the embodiment comprises a puncture assembly 1, a driving assembly 2, a fixing assembly 3 and a liquid injection assembly 4, wherein the puncture assembly 1 comprises a puncture driving piece 11 and a puncture needle 12, the puncture driving piece 11 is used for driving the puncture needle 12 to move along the Z-axis direction, the puncture needle 12 can rotate relative to the puncture driving piece 11 to drive the driving piece 2 to be matched with the puncture driving piece 11, the driving piece 2 is used for driving the puncture driving piece 11 to move along the Y-axis and the X-axis direction, the liquid injection assembly 4 is connected with the puncture needle 12 to output liquid towards the puncture needle 12, the fixing assembly 3 is positioned below the puncture assembly 1, and the fixing assembly 3 is used for bearing an experimental sample.
It will be appreciated that during actual operation, the puncture driving unit 11 can drive the puncture needle 12 to move in the Z-axis direction, so that the puncture depth of the puncture needle 12 can be precisely controlled. The driving assembly 2 can drive the puncture needle 12 to move along the Y-axis direction and the X-axis direction, and can precisely control the puncture position of the puncture needle 12. The liquid injection assembly 4 can simulate the state of an experimental sample in the actual process on one hand, so that the accuracy is improved; on the other hand, if the experimental sample has chips, the chips can be flushed out by the injected liquid, so that the experimental sample can be conveniently observed by experimental staff. In addition, because the puncture needle 12 can rotate relative to the puncture driving piece 11, in the actual experiment process, the puncture angle can be adjusted by adjusting the angle of the puncture needle 12 relative to the puncture driving piece 11, so that the experimental result is better attached to the actual situation. The puncture needle 12 can be connected to the power output end of the puncture driving unit 11 through a spherical hinge, and a locking mechanism is designed on the spherical hinge to lock the puncture needle 12 on the puncture driving unit. Of course, in other embodiments of the present invention, the rotatable connection of the lancet 12 and the lancet driver 11 may be selected according to actual needs and is not limited to the above description.
It should be noted that the subcutaneous implantation type drug administration testing apparatus of the present embodiment further includes a control system 6, wherein the control system 6 is used for controlling the operation states of the puncture driving member 11 and the driving assembly 2, and is used for controlling various displacement sensors inside the system 6. As shown in fig. 1, the control system 6 in the present embodiment is a portable computer. Of course, the control system 6 may be selected according to actual needs, and the specific type of the control system 6 is not limited herein.
In some embodiments, as shown in FIG. 1, the drive assembly 2 includes an X-axis drive set 21 and a Y-axis drive set 22, the X-axis drive set 21 being coupled to the lancing drive 11 to drive the lancing drive 11 to move in the X-axis direction, the Y-axis drive set 22 being coupled to the X-axis drive set 21 to drive the X-axis drive set 21 to move in the Y-axis direction. It can be appreciated that, when the driving assembly 2 is split into the X-axis driving group 21 and the Y-axis driving group 22, the accurate control of the travel of the puncture needle 12 along the X-axis direction and the Y-axis direction and the accurate control of the travel along the X-axis direction can be realized very conveniently in the actual working process.
In some specific embodiments, as shown in fig. 2, the X-axis driving set 21 includes an X-axis fixing base 211, an X-axis driving source 212, and an X-axis sliding block 213, the X-axis fixing base 211 is connected to the Y-axis driving set 22, and the X-axis driving source 212 is disposed on the X-axis fixing base 211; the X-axis sliding block 213 is connected to the X-axis driving source 212, and slides relative to the X-axis fixing base 211 by the driving of the X-axis driving source 212, and the X-axis sliding block 213 is connected to the puncture driving unit 11. It can be understood that the X-axis driving source 212 drives the X-axis sliding block 213 to move the puncture needle 12 along the X-axis direction, and the accurate control of the travel of the puncture needle 12 along the X-axis direction can be realized by controlling the X-axis driving source 212, so that the stable control of the puncture position of the puncture needle 12 is improved.
In some specific embodiments, as shown in fig. 2, the Y-axis driving set 22 includes a Y-axis fixing base 221, a Y-axis driving source 222, and a Y-axis sliding block 223, where the Y-axis driving source 222 is disposed on the Y-axis fixing base 221, the Y-axis sliding block 223 is connected to the Y-axis driving source 222, and slides relative to the Y-axis fixing base 221 under the driving of the Y-axis driving source 222, and the Y-axis sliding block 223 is connected to the X-axis driving set 21. It can be appreciated that the Y-axis driving source 222 drives the Y-axis sliding block 223 to move the puncture needle 12 along the Y-axis direction, and the accurate control of the travel of the puncture needle 12 along the Y-axis direction can be realized by controlling the Y-axis driving source 222, so that the stable control of the puncture position of the puncture needle 12 is improved.
In this embodiment, the Y-axis driving source 222 may be a motor, a ball screw, an electric push rod, a pneumatic or hydraulic driving device, or a combination thereof, and the specific type of the Y-axis driving source 222 is not limited herein.
In some more specific embodiments, the number of Y-axis sliding blocks 223 is two, and the two Y-axis sliding blocks 223 are respectively connected to two ends of the X-axis driving group 21. It will be appreciated that two Y-axis sliders 223 are connected to both ends of the X-axis drive set 21 such that when the Y-axis drive source 222 drives the Y-axis sliders 223 to slide, the X-axis drive set 21 moves more stably, thereby ensuring that the puncture needle 12 moves stably along the Y-axis.
In some embodiments, as shown in fig. 2, the fixing assembly 3 includes a water bath tank 31, a fixing tank 32, and a water pump (not shown), the fixing tank 32 is provided inside the water bath tank 31, the test sample is provided inside the fixing tank 32, and the water pump is provided inside the water bath tank 31 or the fixing tank 32 to output the liquid inside the water bath tank 31 into the fixing tank 32. It can be appreciated that in the actual experiment process, the water pump can input the liquid in the water bath box 31 to the fixed box 32, so that the experiment sample can be soaked in the liquid with a certain temperature, the use scene of the experiment sample implanted into the human body in the actual use process can be well simulated, the test environment is more attached to the actual use environment of the experiment sample, and the test precision is improved.
In some specific embodiments, as shown in fig. 2-3, a fixing clamp 5 is disposed in the fixing box 32, the fixing clamp 5 is used for clamping an experimental sample, the fixing clamp 5 includes a fixing base 51, a movable base 52, an adjusting bolt 53 and an adjusting nut 54, the fixing base 51 is disposed on the bottom wall of the fixing box 32, the movable base 52 is disposed at a distance from the fixing base 51, an exposing hole is disposed on the movable base 52, one end of the adjusting bolt 53 is connected with the fixing base 51, the other end is disposed on the movable base 52 in a penetrating manner, and the adjusting nut 54 is matched on the adjusting bolt 53 and is abutted against the movable base 52. It will be appreciated that when the test sample is mounted, the test sample can be placed on the fixed base 51, and then the adjusting nut 54 is rotated to drive the movable base 52 to be pressed on the test sample, a part of the test sample is exposed from the exposed hole, so that the puncture needle 12 is convenient to puncture, and thus, the test sample is firmly fixed on the fixed clamp 5 in the test process, the test sample is prevented from shaking, and the accuracy of the puncture position is ensured.
In some embodiments, as shown in fig. 1-2, the injection assembly 4 includes an injection fixing seat 41, an injection driving member 42 and an injection needle cylinder 43, the injection driving member 42 is disposed on the injection fixing seat 41, the injection needle cylinder 43 is fixed on the injection fixing seat 41, an injection piston of the injection needle cylinder 43 is connected with the injection driving member 42, and an injection hole of the injection needle cylinder 43 is connected with the puncture needle 12 through an outlet pipe. It will be appreciated that in actual testing, the fluid must be injected into the needle 12 after a specified number of punctures to test whether the test sample is chipped, and if manual fluid injection is used, the experimenter must perform the fluid injection operation at intervals, which is very complex. In this embodiment, the liquid injection assembly 4 includes a liquid injection driving member 42 and a liquid injection syringe 43, where the liquid injection driving member 42 can drive a piston rod of the liquid injection syringe 43 to move, thereby realizing an automatic liquid injection function, reducing the complexity of experimental operation, and improving the automation degree of the subcutaneous implantation type drug administration testing device.
In some specific embodiments, the liquid injection assembly 4 further includes a liquid inlet pipe (not shown) connected to an external liquid source and the liquid injection hole, and a check valve (not shown) disposed on the liquid inlet pipe and the liquid outlet pipe. It will be appreciated that, in the actual operation, after the liquid in the liquid injection syringe 43 is used, the liquid injection driving member 42 drives the liquid injection piston of the liquid injection syringe 43 to move reversely, so that the liquid from the external liquid source can be sucked into the liquid pipe and enter the liquid injection syringe 43, thereby completing the automatic liquid filling of the liquid injection syringe 43. The liquid inlet pipe and the liquid outlet pipe are respectively provided with a one-way valve, so that on one hand, liquid in the liquid injection needle cylinder 43 can be prevented from entering an external liquid source when being injected into the puncture needle 12, and on the other hand, liquid in the puncture needle 12 can be prevented from being sucked when the liquid in the external liquid source is sucked.
In some embodiments, the subcutaneously implantable drug delivery testing device further includes a manipulator (not shown) disposed in juxtaposition with the puncture needle 12, the manipulator being configured to mount the puncture needle 12 to the puncture drive 11 or to detach the puncture needle 12 from the puncture drive 11. It can be appreciated that in the actual experimental process, the mounting and dismounting of the puncture needle 12 can be realized through the manipulator, so that the puncture needles 12 with different types can be automatically replaced to detect, and the automation degree and the compatibility of the subcutaneous implantation type drug administration testing device are improved.
Examples:
as shown in fig. 1 to 3, the subcutaneous implantation type drug administration testing apparatus of the present embodiment includes a puncture assembly 1, a driving assembly 2, a liquid injection assembly 4, a fixing assembly 3 and a manipulator, the puncture assembly 1 includes a puncture driving member 11 and a puncture needle 12, and the puncture driving member 11 is an electric cylinder and is used for driving the puncture needle 12 to move along the Z-axis direction. The driving assembly 2 comprises an X-axis driving group 21 and a Y-axis driving group 22, the X-axis driving group 21 comprises an X-axis fixing seat 211, an X-axis driving source 212 and an X-axis sliding block 213, the X-axis fixing seat 211 is connected with the Y-axis driving group 22, the X-axis driving source 212 is arranged on the X-axis fixing seat 211 and is an electric cylinder, the X-axis sliding block 213 is connected with the X-axis driving source 212 and slides relative to the X-axis fixing seat 211 under the driving of the X-axis driving source 212, and the X-axis sliding block 213 is connected with the puncture driving piece 11. The Y-axis driving group 22 includes a Y-axis fixing base 221, a Y-axis driving source 222, and a Y-axis slider 223, and the Y-axis slider 223 and the Y-axis fixing base 221 are two and are disposed at intervals along the X-axis direction. The Y-axis driving source 222 is disposed on one of the Y-axis fixing bases 221 and is an electric cylinder, one of the Y-axis sliding blocks 223 is connected with the Y-axis driving source 222, and slides relative to the Y-axis fixing base 221 under the driving of the Y-axis driving source 222, and the two Y-axis sliding blocks 223 are respectively connected to two ends of the X-axis fixing base 211. The fixed subassembly 3 includes water bath 31, fixed box 32 and water pump, fixed box 32 establishes inside water bath 31, be equipped with mounting fixture 5 in the fixed box 32, mounting fixture 5 is used for the centre gripping experiment sample, mounting fixture 5 includes unable adjustment base 51, movable seat 52, adjusting bolt 53 and adjusting nut 54, unable adjustment base 51 establishes on the diapire of fixed box 32, movable seat 52 and unable adjustment base 51 interval set up, one end of adjusting bolt 53 links to each other with unable adjustment base 51, the other end wears to establish on movable seat 52, adjusting nut 54 cooperates on adjusting bolt 53, and only support on movable seat 52. The water pump is provided in the water bath tank 31 or the fixed tank 32 to output the liquid in the water bath tank 31 into the fixed tank 32. The liquid injection assembly 4 comprises a liquid injection fixing seat 41, a liquid injection driving piece 42, a liquid injection needle cylinder 43, a liquid inlet pipeline, a liquid outlet pipeline and a one-way valve, wherein the liquid injection driving piece 42 is arranged on the liquid injection fixing seat 41. The injection syringe 43 is fixed on the injection fixing seat 41, an injection piston of the injection syringe 43 is connected with the injection driving piece 42, and an injection hole of the injection syringe 43 is connected with the puncture needle 12 through a liquid outlet pipeline. The liquid inlet pipeline is connected with an external liquid source and the liquid injection hole, and the one-way valve is arranged on the liquid inlet pipeline and the liquid outlet pipeline. A manipulator is provided in parallel with the puncture needle 12 for attaching the puncture needle 12 to the puncture driver 11 or detaching the puncture needle 12 from the puncture driver 11.
The advantages of the subcutaneously implantable drug delivery test device of this embodiment are as follows:
first: the puncture position and the puncture depth can be accurately controlled, and the puncture precision is ensured so as to ensure the detection precision;
second,: the state of the experimental sample in liquid injection can be well simulated;
third,: the state of the experimental sample in the human body can be better simulated;
fourth,: the puncture needle 12 can be automatically installed or replaced so as to realize puncture experiments of puncture needles 12 of different types;
fifth,: the liquid injection component 4 can realize automatic liquid supplement, artificial liquid supplement is not needed in the experimental process, and the operation is simplified;
sixth: after the experimental sample is installed, the experimenter only needs to set parameters in the control system 6, other operations are not needed in the experimental process, and the degree of automation is high.
In the description of the present specification, reference to the term "some embodiments," "other embodiments," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing is merely exemplary of the present invention, and those skilled in the art should not be considered as limiting the invention, since modifications may be made in the specific embodiments and application scope of the invention in light of the teachings of the present invention.
Claims (10)
1. A subcutaneously implantable drug delivery testing device comprising:
the puncture assembly (1), the puncture assembly (1) comprises a puncture driving piece (11) and a puncture needle (12), the puncture driving piece (11) is used for driving the puncture needle (12) to move along the Z-axis direction, the puncture needle (12) can rotate relative to the puncture driving piece (11), and the puncture needle (12) is connected to the power output end of the puncture driving piece 11 through a spherical hinge;
the driving assembly (2) is matched with the puncture driving piece (11), and the driving assembly (2) is used for driving the puncture driving piece (11) to move along the Y-axis and the X-axis directions;
a liquid injection assembly (4), wherein the liquid injection assembly (4) is connected with the puncture needle (12) so as to output liquid towards the puncture needle (12);
the fixing assembly (3), the fixing assembly (3) is located puncture assembly (1) below, and the fixing assembly (3) is used for bearing experimental samples.
2. The subcutaneously implantable drug delivery testing device according to claim 1, wherein the drive assembly (2) comprises:
an X-axis driving group (21), wherein the X-axis driving group (21) is connected with the puncture driving piece (11) to drive the puncture driving piece (11) to move along the X-axis direction;
and the Y-axis driving group (22) is connected with the X-axis driving group (21) to drive the X-axis driving group (21) to move along the Y-axis direction.
3. Subcutaneous implanted drug delivery testing device according to claim 2, characterized in that the X-axis drive group (21) comprises:
the X-axis fixing seat (211), the X-axis fixing seat (211) is connected with the Y-axis driving group (22);
an X-axis driving source (212), wherein the X-axis driving source (212) is arranged on the X-axis fixing seat (211);
the X-axis sliding block (213), the X-axis sliding block (213) is connected with the X-axis driving source (212) and slides relative to the X-axis fixing seat (211) under the driving of the X-axis driving source (212), and the X-axis sliding block (213) is connected with the puncture driving piece (11).
4. The subcutaneously implantable drug delivery testing device according to claim 2, wherein the Y-axis drive set (22) comprises:
a Y-axis fixing base (221);
the Y-axis driving source (222), the Y-axis driving source (222) is arranged on the Y-axis fixing seat (221);
the Y-axis sliding block (223), the Y-axis sliding block (223) is connected with the Y-axis driving source (222) and slides relative to the Y-axis fixing seat (221) under the driving of the Y-axis driving source (222), and the Y-axis sliding block (223) is connected with the X-axis driving group (21).
5. The subcutaneous implanted drug delivery testing device according to claim 4, wherein the number of Y-axis sliding blocks (223) is two, and the two Y-axis sliding blocks (223) are respectively connected to both ends of the X-axis driving group (21).
6. Subcutaneous implantable drug delivery testing device according to any of claims 1-5, characterized in that the fixation assembly (3) comprises:
a water bath tank (31);
the fixing box (32), the fixing box (32) is arranged inside the water bath box (31), and the experimental sample is arranged in the fixing box (32);
the water pump is arranged in the water bath box (31) or the fixed box (32) so as to output the liquid in the water bath box (31) into the fixed box (32).
7. The subcutaneously implantable drug delivery test device according to claim 6, wherein a fixture (5) is provided in the stationary box (32), the fixture (5) being for clamping the experimental sample, the fixture (5) comprising:
a fixed base (51), wherein the fixed base (51) is arranged on the bottom wall of the fixed box (32);
the movable seat (52) is arranged at intervals with the fixed base (51), and the movable seat (52) is provided with an exposure hole;
one end of the adjusting bolt (53) is connected with the fixed base (51), and the other end of the adjusting bolt (53) is arranged on the movable base (52) in a penetrating way;
and the adjusting nut (54) is matched with the adjusting bolt (53) and is stopped on the movable seat (52).
8. Subcutaneous implanted drug delivery testing device according to any of claims 1-5, characterized in that the infusion assembly (4) comprises:
a liquid injection fixing seat (41);
the liquid injection driving piece (42), the liquid injection driving piece (42) is arranged on the liquid injection fixing seat (41);
the liquid injection needle cylinder (43), the liquid injection needle cylinder (43) is fixed on the liquid injection fixing seat (41), an injection piston of the liquid injection needle cylinder (43) is connected with the liquid injection driving piece (42), and a liquid injection hole of the liquid injection needle cylinder (43) is connected with the puncture needle (12) through a liquid outlet pipeline.
9. The subcutaneously implantable drug delivery testing device according to claim 8, wherein the infusion assembly (4) further comprises:
the liquid inlet pipeline is connected with an external liquid source and the liquid injection hole;
the one-way valve is arranged on the liquid inlet pipeline and the liquid outlet pipeline.
10. The subcutaneously implantable drug delivery test device according to any one of claims 1 to 5, wherein the subcutaneously implantable drug delivery test device further comprises:
the manipulator is arranged in parallel with the puncture needle (12), and is used for installing the puncture needle (12) on the puncture driving piece (11) or detaching the puncture needle (12) from the puncture driving piece (11).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210387913.8A CN114965118B (en) | 2022-04-13 | 2022-04-13 | Subcutaneous implantation type drug administration testing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210387913.8A CN114965118B (en) | 2022-04-13 | 2022-04-13 | Subcutaneous implantation type drug administration testing device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114965118A CN114965118A (en) | 2022-08-30 |
| CN114965118B true CN114965118B (en) | 2023-08-22 |
Family
ID=82977782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210387913.8A Active CN114965118B (en) | 2022-04-13 | 2022-04-13 | Subcutaneous implantation type drug administration testing device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114965118B (en) |
Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204016549U (en) * | 2014-08-25 | 2014-12-17 | 黑龙江农业经济职业学院 | A kind of domestic animal continuous medicine-filling device |
| CN207041699U (en) * | 2017-02-23 | 2018-02-27 | 兰州大学 | A kind of puncture outfit that can be used for injection and continuous sucking pleural effusion |
| CN107773305A (en) * | 2017-09-11 | 2018-03-09 | 山东科技大学 | A kind of four-degree-of-freedom tumor puncture auxiliary robot |
| CN108433791A (en) * | 2018-04-26 | 2018-08-24 | 王燕青 | Adjustable needle angle sting device and its system and control method |
| CN109620368A (en) * | 2019-01-30 | 2019-04-16 | 珠海市人民医院 | It is a kind of based on CT guidance under intervening of intelligence sting device |
| CN109900885A (en) * | 2019-02-13 | 2019-06-18 | 清华大学 | Interventional medical equipment and medical material test macro and corresponding experimental method |
| CN210206909U (en) * | 2019-07-09 | 2020-03-31 | 成都旻农农业科技有限公司 | Automatic liquid feeding and absorbing device |
| CN111257546A (en) * | 2020-04-07 | 2020-06-09 | 北京众驰伟业科技发展有限公司 | POCT detection system |
| CN112315513A (en) * | 2020-11-02 | 2021-02-05 | 济南大学 | Novel breast tumor puncture biopsy device |
| CN112370647A (en) * | 2020-10-12 | 2021-02-19 | 珠海横乐医学科技有限公司 | Ultrasonic-guided multi-degree-of-freedom radioactive particle implantation robot |
| CN212748587U (en) * | 2020-05-27 | 2021-03-19 | 贝朗医疗（苏州）有限公司 | Puncture resistance testing device of implanted drug delivery device |
| CN215688294U (en) * | 2021-06-17 | 2022-02-01 | 北京万东医疗科技股份有限公司 | Puncture positioning auxiliary device and puncture assembly |
| CN215874866U (en) * | 2021-08-04 | 2022-02-22 | 张文焕 | Puncture needle positioning transmitter for ultrasonic interventional therapy |
| CN215899838U (en) * | 2021-08-20 | 2022-02-25 | 张绪国 | Puncture drawing liquid retention drainage device |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10555719B2 (en) * | 2013-03-12 | 2020-02-11 | St. Jude Medical Puerto Rico Llc | Ultrasound assisted needle puncture mechanism |
| PL2954926T3 (en) * | 2014-06-12 | 2020-06-15 | Mt.Derm Gmbh | Handheld device for the repeated puncturing of human or animal skin |
| JP6521707B2 (en) * | 2014-07-10 | 2019-05-29 | キヤノン株式会社 | Puncture planning device and puncture system |
-
2022
- 2022-04-13 CN CN202210387913.8A patent/CN114965118B/en active Active
Patent Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204016549U (en) * | 2014-08-25 | 2014-12-17 | 黑龙江农业经济职业学院 | A kind of domestic animal continuous medicine-filling device |
| CN207041699U (en) * | 2017-02-23 | 2018-02-27 | 兰州大学 | A kind of puncture outfit that can be used for injection and continuous sucking pleural effusion |
| CN107773305A (en) * | 2017-09-11 | 2018-03-09 | 山东科技大学 | A kind of four-degree-of-freedom tumor puncture auxiliary robot |
| CN108433791A (en) * | 2018-04-26 | 2018-08-24 | 王燕青 | Adjustable needle angle sting device and its system and control method |
| CN109620368A (en) * | 2019-01-30 | 2019-04-16 | 珠海市人民医院 | It is a kind of based on CT guidance under intervening of intelligence sting device |
| CN109900885A (en) * | 2019-02-13 | 2019-06-18 | 清华大学 | Interventional medical equipment and medical material test macro and corresponding experimental method |
| CN210206909U (en) * | 2019-07-09 | 2020-03-31 | 成都旻农农业科技有限公司 | Automatic liquid feeding and absorbing device |
| CN111257546A (en) * | 2020-04-07 | 2020-06-09 | 北京众驰伟业科技发展有限公司 | POCT detection system |
| CN212748587U (en) * | 2020-05-27 | 2021-03-19 | 贝朗医疗（苏州）有限公司 | Puncture resistance testing device of implanted drug delivery device |
| CN112370647A (en) * | 2020-10-12 | 2021-02-19 | 珠海横乐医学科技有限公司 | Ultrasonic-guided multi-degree-of-freedom radioactive particle implantation robot |
| CN112315513A (en) * | 2020-11-02 | 2021-02-05 | 济南大学 | Novel breast tumor puncture biopsy device |
| CN215688294U (en) * | 2021-06-17 | 2022-02-01 | 北京万东医疗科技股份有限公司 | Puncture positioning auxiliary device and puncture assembly |
| CN215874866U (en) * | 2021-08-04 | 2022-02-22 | 张文焕 | Puncture needle positioning transmitter for ultrasonic interventional therapy |
| CN215899838U (en) * | 2021-08-20 | 2022-02-25 | 张绪国 | Puncture drawing liquid retention drainage device |
Non-Patent Citations (1)
| Title |
|---|
| 一种血透专用多角度可调穿刺针的设计;唐爱静 等;《心理医生》;第23卷(第18期);第327-328页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114965118A (en) | 2022-08-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6893436B2 (en) | Percutaneous wearing device for vein access | |
| CN111671441A (en) | Robot draws blood | |
| CN111603223A (en) | Puncture device | |
| CN114965118B (en) | Subcutaneous implantation type drug administration testing device | |
| CN216877582U (en) | Automatic injection device for radioactive liquid medicine | |
| CN112842484B (en) | Safety auxiliary tool for puncture equipment | |
| CN110236657B (en) | Disposable thyroid puncture device positioning device | |
| CN215821097U (en) | Device for operating a rigid or flexible puncture needle | |
| CN219049864U (en) | Automatic injection device of angiocardiography syringe | |
| CN210990901U (en) | Auxiliary device for intravenous injection of rat tail | |
| CN214970240U (en) | Infusion device | |
| CN212879499U (en) | Fixing device is assisted in puncture | |
| CN215534875U (en) | Adjustable puncture assistor for nephrology department | |
| CN114305604A (en) | Safety injection puncture instrument | |
| CN220231261U (en) | A testing arrangement for examining infusion port is with silica gel membrane puncture resistance | |
| US20100076340A1 (en) | Device and method to extract material of a material reservoir | |
| CN106236317A (en) | A kind of trace injection instrument | |
| CN215134937U (en) | Mechanical arm injector based on image recognition | |
| CN116077759B (en) | Radiopharmaceutical injection device and method of operation thereof | |
| CN219847647U (en) | Punching seal pipe | |
| CN211325438U (en) | Breast tumor puncture positioning device | |
| CN219167336U (en) | Syringe subassembly stable form high pressure syringe | |
| CN110141395A (en) | A kind of tail vein injection auxiliary device | |
| CN215191600U (en) | Blood sampling needle head clamping structure | |
| CN215424975U (en) | Positioning and guiding device for CT or nuclear magnetic resonance puncture |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |