CN114343578A - In vivo analyte detection system - Google Patents
In vivo analyte detection system Download PDFInfo
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- CN114343578A CN114343578A CN202111665532.3A CN202111665532A CN114343578A CN 114343578 A CN114343578 A CN 114343578A CN 202111665532 A CN202111665532 A CN 202111665532A CN 114343578 A CN114343578 A CN 114343578A
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- 238000001514 detection method Methods 0.000 title claims abstract description 97
- 239000012491 analyte Substances 0.000 title claims abstract description 31
- 238000001727 in vivo Methods 0.000 title claims abstract description 23
- 238000004891 communication Methods 0.000 claims abstract description 10
- 238000012544 monitoring process Methods 0.000 claims abstract description 8
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
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- 238000010586 diagram Methods 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 230000004913 activation Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
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Abstract
The invention discloses an in vivo analyte monitoring system, comprising: a biosensor for detecting an analyte in a living body and generating detection information; the transmitter is connected with the biosensor and used for acquiring detection information; the data receiving end can be in wireless communication connection with the transmitter and is used for sending a control instruction to the transmitter so as to instruct the transmitter to execute an operation corresponding to the control instruction; wherein the transmitter switches the operating power based on the control instruction. Because different control commands can control the transmitter to execute different operations, and the power required by different operations is different, therefore, the transmitter is switched into different working powers through different control commands, so that the electric energy loss of the transmitter is reduced, and the cruising ability of the transmitter is improved.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to an in-vivo analyte detection system.
Background
Existing continuous monitoring devices allow patients to continuously track bodily analytes, such as blood glucose, lactate, etc., on a regular basis to continuously track their health. For example, a continuous blood glucose monitor that is worn next to the skin of a patient samples blood glucose data at a constant detection rate by a detection device that is worn next to the skin and transmits the data to a data receiving end for observation by the patient. This continuity of data sampling allows patients to better and more closely understand their physical condition and changes from hour to hour and even minute to minute.
Because the continuity when detecting analyte needs the work of detection device continuity, and detection device keeps its work through self electricity storage, leads to detection device's duration relatively poor, needs the user to often take off the partial work of dismantling and charge.
Therefore, how to improve the endurance of the continuous monitoring equipment becomes a technical problem to be solved urgently.
Disclosure of Invention
In order to solve the technical problem of improving the cruising ability of continuous monitoring equipment in the prior art explained in the background art, the invention provides an in-vivo analyte detection system.
The application discloses in vivo analyte monitoring system includes: a biosensor for detecting an analyte in a living body and generating detection information; the transmitter is connected with the biosensor and used for acquiring detection information; the data receiving end can be in wireless communication connection with the transmitter and is used for sending a control instruction to the transmitter so as to instruct the transmitter to execute an operation corresponding to the control instruction; wherein the transmitter switches the operating power based on the control instruction.
Optionally, the control instruction includes a continuous work instruction, an intermittent work instruction, and a stop work instruction; the transmitter is switched to a first working power state when receiving a continuous working instruction; the transmitter is switched to a second working power state when receiving the intermittent working instruction; when the transmitter receives a stopping work instruction, the transmitter is switched to a third work power state; and the power corresponding to the first working power state, the second working power state and the third working power state is reduced in sequence.
Optionally, each time the transmitter executes an operation corresponding to the control instruction, the transmitter sends an operation execution completion instruction for indicating the operation corresponding to the current control instruction to the data receiving end, so that the data receiving end sends a next control instruction.
Optionally, the transmitter is charged through the charging base, during the charging process, the transmitter enters a third operating power state, and when the connection with the charging base is disconnected, the transmitter is switched from the third operating power state to the second operating power state.
Optionally, when the data receiving end establishes a connection with the transmitter, the data receiving end sends a historical data request instruction to the transmitter, and the transmitter switches to the first operating power state based on the historical data request instruction and sends the historical data to the data receiving end.
Optionally, when the data receiving end is disconnected from the transmitter, the transmitter switches to the second operating power state, acquires the detection information in the second operating power state, and stores the detection information as the historical data.
Optionally, when the transmitter acquires the detection information, the transmitter performs coding identification on the detection information, and stores the detection information with the coding identification information as historical data; the request history data instruction comprises a data request with coded identification information, and the transmitter transmits the history data according to the coded identification information in the request history data instruction.
Optionally, when the transmitter sends the historical data to the data receiving end, the data receiving end sends a detection instruction to the transmitter, and the transmitter switches from the first working power state to the second working power state based on the detection instruction, acquires the detection information in the second working power state, and sends the detection information to the data receiving end.
Optionally, when the preset detection period is reached, the data receiving end sends an end detection instruction to the transmitter, and the transmitter switches from the second operating power state to the third operating power state based on the end detection instruction.
Optionally, when the data receiving end establishes a connection with the transmitter, the transmitter is activated, and the transmitter enters a state of acquiring the detection information.
In the embodiment of the application, the biosensor is used for detecting an analyte in a living body and generating detection information; the transmitter is connected with the biosensor and used for acquiring detection information; the data receiving end can be in wireless communication connection with the transmitter and is used for sending a control instruction to the transmitter so as to instruct the transmitter to execute an operation corresponding to the control instruction; the transmitter switches operating power based on the control instructions. Because different control commands can control the transmitter to execute different operations, and the power required by different operations is different, therefore, the transmitter is switched into different working powers through different control commands, so that the electric energy loss of the transmitter is reduced, and the cruising ability of the transmitter is improved.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention and not to limit the invention. In the drawings:
FIG. 1 is a schematic view of an in vivo analyte detection system according to one embodiment of the present invention.
FIG. 2 is a schematic diagram of the components of an in vivo analyte detection system in accordance with one embodiment of the present invention.
FIG. 3 is a schematic view of a biosensor implantation process according to an embodiment of the present invention;
FIG. 4 is an interactive schematic of an in vivo analyte detection system according to one embodiment of the present invention.
Reference numerals: the device comprises a biosensor 10, a transmitter 20, a data receiving end 30, a charging base 40, a needle assisting device assembly 100 and a needle assisting device 101.
Detailed Description
In order to more clearly understand the technical features, objects, and effects of the present invention, embodiments of the present invention will now be described with reference to the accompanying drawings, in which the same reference numerals indicate the same or structurally similar but functionally identical elements.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and therefore the scope of the present invention is not limited by the specific embodiments disclosed below.
The present application proposes an in vivo analyte detection system, which, as shown in fig. 1, may comprise: a biosensor 10 for detecting an analyte in a living body and generating detection information; a transmitter 20 connected to the biosensor 10 for acquiring detection information; a data receiving end 30, capable of being connected with the transmitter 20 in a wireless communication manner, and configured to send a control instruction to the transmitter 20 to instruct the transmitter 20 to perform an operation corresponding to the control instruction; wherein the transmitter 20 switches the operating power based on the control instructions.
As an exemplary embodiment, the biosensor 10 may be implanted in the individual through an auxiliary device, wherein the biosensor 10 may include an implanted portion and an exposed portion exposed to the individual for connection with the transmitter 20, the implanted portion may generate an electrical signal by chemically reacting with an analyte in a cell fluid in the individual to characteristically generate the sensing information, and the transmitter 20 is connected to the exposed portion through an electrode to receive the electrical signal, i.e., receive the sensing information, and store the sensing information. In the present embodiment, when the data receiving end 30 establishes a communication connection with the transmitter 20, a control command may be sent to the transmitter 20, and the control command may control the transmitter 20 to periodically acquire the electrical signal of the sensor and store the electrical signal as the detection information; the transmitter 20 may also be controlled to periodically send detection information to the data receiving end 30; the transmitter 20 may also be controlled to transmit historical data to the data receiving end 30. In the present embodiment, the transmitter 20 switches to the operating power corresponding to the control command when receiving a different command.
In the present application, the biosensor 10 is used to detect an analyte in a living body and generate detection information; a transmitter 20 connected to the biosensor 10 for acquiring detection information; a data receiving end 30, capable of being connected with the transmitter 20 in a wireless communication manner, and configured to send a control instruction to the transmitter 20 to instruct the transmitter 20 to perform an operation corresponding to the control instruction; the transmitter 20 switches the operating power based on the control instructions. Because different control commands can control the transmitter 20 to perform different operations, and the power required by the different operations is different, the transmitter 20 is switched to different working powers according to the different control commands, so as to reduce the power consumption of the transmitter 20 and improve the cruising ability of the transmitter 20.
As an exemplary embodiment, referring to fig. 2, an in vivo analyte monitoring system may comprise a needle assist assembly 100, a transmitter 20, a charging base 40 of transmitter 20, and a data receiving end 30, which may comprise a needle assist 101 and a biosensor 10, see schematic diagram of biosensor implantation process shown in fig. 3, S1, with the protective membrane removed; s2, unlocking the protection of the needle assisting device 101; s3, triggering an implantation button; s4, separating the biosensor 10, and removing the needle booster 101; s5, fastening the emitter 20; s6, screwing the fixed emitter 20 and the biosensor 10. The biosensor 10 is implanted into an individual by the user operating the needle booster 101, the transmitter 20 is screwed on the biosensor 10, the transmitter 20 is connected with the electrode of the biosensor 10 through the conductive column, the electric signal of the biosensor 10 is obtained, and the detection information of the activation region is obtained. In this embodiment, the transmitter 20 may also be fixed to the biosensor 10 by magnetic attraction, and coupled to the biosensor 10 by wireless means, such as a coupling coil, to obtain the electrical signal of the biosensor 10.
In this embodiment, the data receiving end 30 may be a data acquisition terminal for monitoring an in vivo analyte, or may be a mobile terminal, such as a mobile phone, a tablet computer, and the like, where the data receiving end 30 and the transmitter 20 may be connected in a wireless communication manner through bluetooth, a wireless network, and the like, and the transmitter 20 may perform encoding and identifying on the detection information after acquiring the detection information, and store the detection information according to the encoding and identifying, or may perform encoding and identifying on the detection information after acquiring the detection information, and directly forward the detection information to the data receiving end 30. In this embodiment, the data receiving end 30 automatically sends an activation command to activate the transmitter 20 after establishing a connection with the transmitter 20, and the transmitter 20 can acquire the electrical signal of the biosensor 10 at a predetermined fixed time interval after being activated and convert the electrical signal into detection information.
As an exemplary embodiment, if the data receiving end 30 is kept connected to the transmitter 20, the transmitter 20 automatically transmits the detection information of the coded identification to the data receiving end 30 at regular time intervals. If the data receiving terminal 30 is disconnected from the transmitter 20, the transmitter 20 may acquire the electrical signal of the biosensor 10 at predetermined fixed time intervals during the disconnection and may convert the signal into detection information as history data. After the data receiving end 30 is disconnected from the transmitter 20 for a period of time, and then the connection is established again, the data receiving end 30 sends a data request with a coded identifier to the transmitter 20 to represent the position of the detection information received by the data receiving end 30 when the connection is disconnected, and the transmitter 20 sends the historical data stored in the disconnection period to the data receiving end 30 according to the coded identifier information of the data request.
As an exemplary embodiment, the control instruction may include a continuous operation instruction, an intermittent operation instruction, and a stop operation instruction, and for example, the continuous operation instruction may include an instruction instructing the transmitter 20 to transmit the history data, the intermittent operation instruction may include an instruction to acquire an electric signal of the biosensor 10 at preset fixed time intervals, an instruction to transmit the detection information at preset fixed time intervals, and the like, and the stop operation instruction may include an instruction to suspend acquisition of an electric signal of the biosensor 10, an instruction to suspend transmission of the detection information, and the like. In the present embodiment, the transmitter 20 switches to the first operating power state when receiving the continuous operating command; the transmitter 20 switches to the second operating power state when receiving the intermittent operating command; the transmitter 20 switches to a third operating power state when receiving the stop operating command; and the power corresponding to the first working power state, the second working power state and the third working power state is reduced in sequence.
And in the first working power state, the high-power working state or the full-power working state is adopted, the historical data can be continuously transmitted, and therefore the forwarding of the historical data can be completed as soon as possible. In the second operating power state, the operating power may be a medium power operating state or an intermittent operating state, and the operating power may be full power when the electrical signal of the biosensor 10 is acquired and the detection information is transmitted, and may be low power when the electrical signal is acquired or the detection information is transmitted, thereby saving power consumption as much as possible. In the third operating power state, the operating circuit may be in a low power operating state or a standby state, and in the standby state, the connection between the operating circuit and the power supply may be closed, so as to reduce the consumption of electric energy, thereby prolonging the cruising ability of the transmitter 20 and facilitating the use of the user.
As an exemplary embodiment, the transmitter 20 is charged through the charging base 40, during the charging process, the transmitter 20 enters a third working power state, that is, enters a low power state or a standby state, and when the connection with the charging base 40 is disconnected, the transmitter 20 may automatically turn on by detecting a charging end signal or a charging completion signal for disconnecting the connection with the charging base 40, connect the working circuit to the power supply, open the wireless interface, and enter a state to be activated; after establishing connection with the data receiving terminal 30, the state is switched to the second working power state, and the working state of acquiring the electrical signal of the biosensor 10 according to the preset fixed time interval is entered, and the working state of sending the detection information according to the preset fixed time interval is entered. The charging is carried out in a standby state or a shutdown state, the charging is automatically started after the charging base 40 is separated or the charging is finished, and the state to be activated is entered, and the triggering of other factors is not needed, so that the use by a user is facilitated.
As an exemplary embodiment, after the transmitter 20 is powered on, a wireless connection may be automatically established with the data receiving end 30 in a wireless communication manner, for example, taking the data receiving end 30 as a mobile terminal for illustration, an application program for viewing and receiving detection information is installed on the mobile terminal, when the application program is in an operating state, the application program may be automatically connected with the transmitter 20, or may be connected with the transmitter 20 in a manual network distribution manner, after the connection is established, the data receiving end 30 may automatically issue an instruction to instruct the transmitter 20 to complete an operation corresponding to the instruction, and when the transmitter 20 performs an operation corresponding to a control instruction, the data receiving end 30 sends an operation execution completion instruction to instruct the current control instruction, so that the data receiving end 30 sends a next control instruction. The data receiving end 30 can automatically and continuously receive the detection information sent by the transmitter 20. No manual operation is required.
For example, a continuous work instruction is taken as a request history data instruction, an intermittent work instruction is taken as a detection instruction, and a stop work instruction is taken as an end detection instruction:
when the data receiving end 30 establishes a connection with the transmitter 20, the data receiving end 30 sends a request historical data instruction to the transmitter 20, the transmitter 20 switches to the first operating power state based on the request historical data instruction, and sends the historical data to the data receiving end 30.
In the first operating power state, the transmitter 20 may continuously transmit the historical data to the data receiving terminal 30, and may also acquire the electrical signal of the biosensor 10 at a preset time interval and store the electrical signal as the historical data until the latest acquired detection information is transmitted to the data receiving terminal 30, so as to characterize that the transmission of the historical data is completed.
When the transmitter 20 sends the historical data to the data receiving end 30, the data receiving end 30 may send a detection instruction to the transmitter 20, and the transmitter 20 switches from the first operating power state to the second operating power state based on the detection instruction, acquires the detection information in the second operating power state, and sends the detection information to the data receiving end 30.
When the preset detection period is reached, the data receiving end 30 sends an end detection instruction to the transmitter 20, and the transmitter 20 switches from the second operating power state to the third operating power state based on the end detection instruction.
The control process for an in vivo analyte monitoring system is illustrated with reference to the signaling interaction diagram shown in FIG. 4:
s10, transmitter 20 is charged and in a third operating power state.
S20, the transmitter 20 is disconnected from the charging base 40, the transmitter 20 is turned on, and the third operating power state is switched to the second operating power state.
S30, the transmitter 20 establishes a communication connection with the data receiving end 30.
S40, the data receiving end 30 sends a request history data command to the transmitter 20.
S50, the transmitter 20 will switch to the first operating power state based on the data history data request command.
S60, the transmitter 20 transmits the historical data to the data receiving end 30 in the first operating power state.
S70, when the data receiving end 30 completes receiving the historical data, it sends a detection command to the transmitter 20.
S80, the transmitter 20 switches from the first operating power state to the second operating power state according to the detection command, and obtains the detection information in the second operating power state.
S90, the transmitter 20 sends detection information to the data receiving end 30.
S100, when the data receiving end 30 reaches the detection period, it sends an end detection instruction to the transmitter 20.
S110, the transmitter 20 switches from the second operating power state to the third operating power state according to the detection ending instruction, and ends the operation of acquiring the detection information.
The transmitter and the data receiving terminal also include memories, which may include memory and non-volatile memory, that provide instructions and data to the processor for execution. Illustratively, the Memory may be a high-speed Random-Access Memory (RAM), and the non-volatile Memory may be at least 1 disk Memory.
In the above-mentioned interactive mode between the transmitter and the data receiving terminal, the corresponding execution instruction may be read from the non-volatile memory first and then executed in the memory, or the corresponding execution instruction may be obtained from other devices first and then executed. The processor, when executing the execution instructions stored in the memory, can implement the interaction between the transmitter and the data receiving terminal.
So far, the technical solutions of the present disclosure have been described in connection with the foregoing embodiments, but it is easily understood by those skilled in the art that the scope of the present disclosure is not limited to only these specific embodiments. The technical solutions in the above embodiments can be split and combined, and equivalent changes or substitutions can be made on related technical features by those skilled in the art without departing from the technical principles of the present disclosure, and any changes, equivalents, improvements, and the like made within the technical concept and/or technical principles of the present disclosure will fall within the protection scope of the present disclosure.
The embodiments in the present specification are described in a progressive manner, and the same and similar parts among the embodiments are referred to each other, and each embodiment focuses on the differences from the other embodiments. In particular, for the system embodiment, since it is substantially similar to the method embodiment, the description is simple, and for the relevant points, reference may be made to the partial description of the method embodiment.
The above are merely examples of the present invention, and are not intended to limit the present invention. Various modifications and alterations to this invention will become apparent to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the scope of the claims of the present invention.
Claims (10)
1. An in vivo analyte monitoring system, comprising:
a biosensor for detecting an analyte in a living body and generating detection information;
the transmitter is connected with the biosensor and is used for acquiring the detection information;
the data receiving end can be in wireless communication connection with the transmitter and is used for sending a control instruction to the transmitter so as to instruct the transmitter to execute an operation corresponding to the control instruction;
wherein the transmitter switches operating power based on the control instructions.
2. The in vivo analyte detection system of claim 1 wherein said control instructions comprise a continuous duty instruction, an intermittent duty instruction, and a rest duty instruction;
the transmitter is switched to a first working power state when receiving the continuous working instruction;
the transmitter is switched to a second working power state when receiving the intermittent working instruction;
when the transmitter receives the stopping work instruction, the transmitter is switched to a third work power state;
and the power corresponding to the first working power state, the second working power state and the third working power state is reduced in sequence.
3. The in vivo analyte detection system according to claim 2, wherein said transmitter transmits an operation execution completion instruction indicating a corresponding operation to a current control instruction to said data receiving terminal every time an operation corresponding to said control instruction is completed, so that said data receiving terminal transmits a next said control instruction.
4. The in vivo analyte detection system of claim 2, wherein said transmitter is charged by a charging base, said transmitter entering a third operating power state during charging, said transmitter switching from said third operating power state to said second operating power state upon disconnection from said charging base.
5. The in vivo analyte detection system of claim 2 or 3 wherein upon said data receiving end establishing a connection with said transmitter, said data receiving end sends a request historical data instruction to said transmitter, said transmitter switches to said first operating power state based on said request historical data instruction and sends historical data to the data receiving end.
6. The in vivo analyte detection system of claim 5, wherein said transmitter switches to a second operating power state when said data receiving end is disconnected from said transmitter, and acquires said detection information at said second operating power state, storing said detection information as historical data.
7. The in vivo analyte detection system of claim 6, wherein said transmitter, upon acquiring said detection information, encodes identification information for said detection information and stores the detection information with encoded identification information as said historical data; the request historical data instruction comprises a data request with coded identification information, and the transmitter transmits the historical data according to the coded identification information in the request historical data instruction.
8. The in vivo analyte detection system of claim 5, wherein upon completion of said transmitter sending historical data to said data receiving end, said data receiving end sends a detection instruction to said transmitter, said transmitter switches from said first operating power state to said second operating power state based on said detection instruction, and acquires said detection information in said second operating power state and sends it to said data receiving end.
9. The in vivo analyte detection system of claim 8, wherein upon reaching a preset detection period, said data receiving end sends an end detection instruction to said transmitter, said transmitter switching from said second operating power state to said third operating power state based on said end detection instruction.
10. The in vivo analyte detection system of claim 5, wherein said data receiving end, upon establishing a connection with said transmitter, activates said transmitter to bring said transmitter into a state to acquire said detection information.
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| CN202111665532.3A CN114343578A (en) | 2021-12-30 | 2021-12-30 | In vivo analyte detection system |
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| CN202111665532.3A CN114343578A (en) | 2021-12-30 | 2021-12-30 | In vivo analyte detection system |
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