CN113533762A - Reagent storage device - Google Patents

Reagent storage device Download PDF

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Publication number
CN113533762A
CN113533762A CN202010323370.4A CN202010323370A CN113533762A CN 113533762 A CN113533762 A CN 113533762A CN 202010323370 A CN202010323370 A CN 202010323370A CN 113533762 A CN113533762 A CN 113533762A
Authority
CN
China
Prior art keywords
reagent
storage device
reagent storage
cold end
hot
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202010323370.4A
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Chinese (zh)
Inventor
张震
何太云
李双龙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Increcare Biotech Co Ltd
Original Assignee
Shenzhen Increcare Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Shenzhen Increcare Biotech Co Ltd filed Critical Shenzhen Increcare Biotech Co Ltd
Priority to CN202010323370.4A priority Critical patent/CN113533762A/en
Priority to PCT/CN2020/087497 priority patent/WO2021212537A1/en
Publication of CN113533762A publication Critical patent/CN113533762A/en
Pending legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25DREFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D19/00Arrangement or mounting of refrigeration units with respect to devices or objects to be refrigerated, e.g. infrared detectors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00594Quality control, including calibration or testing of components of the analyser
    • G01N35/00613Quality control
    • G01N35/00663Quality control of consumables
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00722Communications; Identification
    • G01N35/00732Identification of carriers, materials or components in automatic analysers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • G01N2035/00435Refrigerated reagent storage
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00594Quality control, including calibration or testing of components of the analyser
    • G01N35/00613Quality control
    • G01N35/00663Quality control of consumables
    • G01N2035/00673Quality control of consumables of reagents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00722Communications; Identification
    • G01N35/00732Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742Type of codes
    • G01N2035/00752Type of codes bar codes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system
    • G01N2035/0401Sample carriers, cuvettes or reaction vessels
    • G01N2035/0429Sample carriers adapted for special purposes
    • G01N2035/0436Sample carriers adapted for special purposes with pre-packaged reagents, i.e. test-packs
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system
    • G01N2035/0439Rotary sample carriers, i.e. carousels
    • G01N2035/0443Rotary sample carriers, i.e. carousels for reagents

Abstract

The present invention relates to a reagent storage device comprising: the pot body is provided with a containing cavity. The storage mechanism comprises at least two storage units, each storage unit comprises a rotary disc and a reagent box, the rotary discs are located in the accommodating cavities, the rotary discs can rotate in the accommodating cavities, and the reagent boxes are arranged on the rotary discs and used for storing reagents. And the refrigerating mechanism is connected with the pot body so as to keep the accommodating cavity at a set temperature. Because the storage mechanism comprises at least two storage units, the turntables of the storage units are all positioned in the accommodating cavities of the pan body, namely all the turntables share one pan body, so that the reagent storage device is more compact in structure. In order to meet the requirement of high test throughput, the number of the turntables is increased to increase the carrying number of the reagent kit, so that each turntable can be ensured to have a reasonable size, the processing precision of the turntables is ensured, and the structural compactness of the reagent storage device is further ensured.

Description

Reagent storage device
Technical Field
The invention relates to the technical field of medical instruments, in particular to a reagent storage device.
Background
The immunoassay system uses chemiluminescence or fluorescence excitation and immunoreaction principles to correlate the optical signal with the concentration of a substance to be detected to analyze the content of the substance to be detected in a sample, and is increasingly widely applied due to the characteristics of high sensitivity, specificity, wide linear range and the like. With the increase of the amount of the sample to be detected, the clinical laboratory has higher requirements on the volume and the test throughput of the immunoassay system.
The reagent storage device is an important component of the immunoassay system, and has an important influence on the volume and the test throughput of the whole immunoassay system. With the conventional reagent storage device, in order to increase the storage amount of the reagent disk for the reagent containers to improve the test throughput, the accommodating positions for setting the reagent containers on the reagent disk are generally increased, thereby resulting in a larger volume of the whole reagent storage device. The reagent storage device becomes larger in size, so that the difficulty of motion control of the reagent storage device is increased, and the processing precision of the reagent storage device is more challenging.
Disclosure of Invention
One technical problem solved by the present invention is how to make the reagent storage device more compact in construction.
A reagent storage device comprising:
the pot body is provided with an accommodating cavity;
the storage mechanism comprises at least two storage units, each storage unit comprises a rotary disc and a reagent box, the rotary discs are positioned in the accommodating cavities and can rotate in the accommodating cavities, and the reagent boxes are arranged on the rotary discs and used for storing reagents; and
the refrigerating mechanism is connected with the pot body so as to keep the accommodating cavity at a set temperature.
In one embodiment, the cold end units are symmetrically distributed in the accommodating cavity along a connecting line of centers of at least two rotating discs or a vertical median line of the connecting line of the centers of at least two rotating discs.
In one embodiment, the refrigeration mechanism comprises a cold end unit, a hot end unit and a refrigeration piece, the cold end unit is located in the accommodating cavity, the hot end unit is located outside the accommodating cavity, and one end of the cold end unit and one end of the hot end unit are respectively connected with the cold end and the hot end of the refrigeration piece.
In one embodiment, the cold end unit is located in a gap between two adjacent turntables, and the cold end unit comprises a mounting seat, a cold end cooling fin and a cold end fan, wherein the mounting seat is arranged on the cold end cooling fin, and the cold end fan is arranged on the mounting seat.
In one embodiment, the number of cold end units is an even number divided into at least one pair.
In one embodiment, the cold side fans on each pair of cold side units blow air in opposite directions.
In one embodiment, the hot end unit comprises a hot end heat sink and a hot end fan, the hot end heat sink is connected with the hot end of the refrigerating sheet and used for absorbing heat of the hot end unit of the refrigerating sheet, and the hot end fan is arranged at two ends of the hot end heat sink.
In one embodiment, the hot end unit further includes a heat dissipation air duct connected to an end of the hot end heat sink and disposed around the hot end fan, and the hot end fan discharges heat of the hot end heat sink from the heat dissipation air duct.
In one embodiment, the heat dissipation air duct is positioned below the pot body.
In one embodiment, the pot body comprises a bottom cover, a top cover and a side frame, the bottom cover and the top cover are respectively connected with two ends of the side frame, the bottom cover, the top cover and the side frame jointly enclose the accommodating cavity, the rotary disc is rotatably connected with the bottom cover, and the refrigerating mechanism is arranged on the bottom cover.
In one embodiment, at least two groups of sampling ports are arranged on the top cover, and each group of sampling ports corresponds to one storage unit.
In one embodiment, the cross-sectional shape of the side frame is rectangular or racetrack.
In one embodiment, the pot further comprises a scanner arranged on the pot body, and the scanner is located in the accommodating cavity and used for identifying bar code information on the reagent kit.
In one embodiment, the storage unit further comprises a blending gear arranged around the rotary disc, the reagent kit comprises a kit body, a rotating reagent bottle and a transmission gear, the kit body is arranged on the rotary disc, the rotating reagent bottle is rotationally connected with the kit body, and the transmission gear is arranged on the rotating reagent bottle and meshed with the blending gear.
In one embodiment, each of the storage units is loaded with all reagents required for the corresponding analysis item.
In one embodiment, the storage unit further comprises a rotating shaft and a driver, the rotating shaft is arranged in the pot body in a penetrating mode and is connected with the rotating disc, and the driver is located outside the accommodating cavity and drives the rotating shaft to rotate.
In one embodiment, the driver comprises a motor, a driving wheel, a driven wheel and a synchronous belt, wherein the driving wheel is connected with the motor, the driven wheel is arranged on the rotating shaft, and the synchronous belt is sleeved on the driving wheel and the driven wheel.
In one embodiment, the cooling mechanism includes a heat dissipation duct for discharging heat, the heat dissipation duct passing through a gap between the two drives.
One technical effect of one embodiment of the invention is that: because the storage mechanism comprises at least two storage units, the turntables of the storage units are all positioned in the accommodating cavities of the pan body, namely all the turntables share one pan body, so that the reagent storage device is more compact in structure. In addition, the refrigerating mechanism can keep the accommodating cavity at a set temperature, and because the rotary discs of the plurality of storage units and the reagent boxes are positioned in the same accommodating cavity, the temperatures of reagents in all the reagent boxes can be kept consistent, and the accuracy of subsequent test results is ensured. Moreover, in order to meet the requirement of high test throughput, the number of the turntables is increased to increase the carrying number of the reagent kit, so that each turntable can be ensured to have a reasonable size, the processing precision of the turntables is ensured, and the structural compactness of the reagent storage device is further ensured. In addition, the total weight of the single rotating disc and the reagent box carried by the rotating disc is in a reasonable value range, so that the phenomenon that the difficulty of controlling the rotating disc movement is increased due to overlarge load can be prevented.
Drawings
FIG. 1 is a schematic perspective view of a reagent storage device according to an embodiment;
FIG. 2 is a schematic exploded view of the reagent storage device of FIG. 1;
FIG. 3 is a schematic view of a portion of the reagent storage device of FIG. 1 with the support plate removed;
FIG. 4 is a schematic view of a partial structure of the reagent storage device shown in FIG. 1 including a storage unit;
FIG. 5 is a perspective view of FIG. 4 from another perspective;
FIG. 6 is an enlarged view of the structure at A in FIG. 5;
FIG. 7 is a schematic partial perspective sectional view of the reagent storage device shown in FIG. 1.
Detailed Description
To facilitate an understanding of the invention, the invention will now be described more fully with reference to the accompanying drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "inner", "outer", "left", "right" and the like as used herein are for illustrative purposes only and do not represent the only embodiments.
Referring to fig. 1 and 2, a reagent storage device 10 according to an embodiment of the present invention includes a pot 100, a storage mechanism 200, and a refrigeration mechanism 300, where the storage mechanism 200 includes at least two storage units 210.
In some embodiments, the pan body 100 includes a side frame 110, a top cover 120 and a bottom cover 130, wherein the bottom cover 130 and the top cover 120 are both in a flat plate structure and are horizontally arranged, the side frame 110 is in a ring structure and is vertically arranged, the top cover 120 is connected with the upper end of the side frame 110, the bottom cover 130 is connected with the lower end of the side frame 110, and the bottom cover 130, the top cover 120 and the side frame 110 enclose a closed accommodating cavity 101. The cross section of the side frame 110 is rectangular or racetrack shaped, which makes the side frame 110 easy to process, and makes the whole pan body 100 well ensure the processing precision on the basis of lower processing cost. At least two groups of sampling ports 121 are arranged on the top cover 120, each group of sampling ports 121 corresponds to one storage unit 210, and a sampling needle is used for entering and exiting the storage unit 210 to suck a reagent. Each set of sampling ports 121 provides for a sampling needle to reach multiple cavities on the reagent cartridge 212 of the storage unit 210.
Referring to fig. 2, fig. 3 and fig. 4, in some embodiments, there may be two or more memory cells 210, and the embodiment takes two memory cells 210 as an example for description. Each storage unit 210 includes a turntable 211, a reagent cartridge 212, a kneading gear 213, a rotation shaft 214, and a driver 215. The turntable 211, the reagent kit 212 and the mixing gear 213 are located in the accommodating cavity 101, and the driver 215 is located outside the accommodating cavity 101. The rotating shaft 214 is inserted into the bottom cover 130 of the pot body 100, the upper end of the rotating shaft 214 is connected with the rotating disc 211, and the lower end of the rotating shaft 214 is located outside the accommodating cavity 101 and connected with the driver 215. The rotary disk 211 is a disc-shaped structure, a plurality of mounting positions are arranged on the rotary disk 211 and are arranged at intervals along the circumferential direction of the rotary disk 211, the reagent cartridges 212 are in one-to-one correspondence with the mounting positions, the reagent cartridges 212 are fixed on the mounting positions, the number of the mounting positions on each rotary disk 211 can be 15-50, for example, the number of the mounting positions on each rotary disk 211 can be 25, so that 50 reagent cartridges 212 can be stored on line by two rotary disks 211 at the same time. Each storage unit 210 is loaded with all reagent components required by a corresponding analysis item, so that all reagent components of the analysis item can be absorbed by a sampling needle on the same storage unit 210, and the problem that one analysis item needs to absorb reagents in two storage units 210 is solved, thereby effectively avoiding the problems of low reagent absorption efficiency, inconvenience in loading and unloading of the reagent kit 212 and the like in the same item.
The driver 215 is used for driving the rotating shaft 214 to rotate, so that the rotating shaft 214 drives the rotating disc 211 to rotate, when the rotating disc 211 rotates around the rotating shaft 214, the relative position of the reagent cartridge 212 and the rotating disc 211 is kept constant, and the reagent cartridge 212 revolves around the rotating shaft 214 along with the rotating disc 211.
Referring to fig. 5 and 6, the reagent cartridge 212 includes a cartridge body 212a, a rotary reagent bottle 212b, a homogeneous reagent bottle 212c, and a driving gear. The cassette body 212a is disposed on the mounting position of the turntable 211, the cassette body 212a may be opened with a plurality of cavities, and the rotary reagent bottle 212b and the homogeneous reagent bottle 212c are accommodated in different cavities. The number of homogeneous reagent bottles 212c may be plural, and each homogeneous reagent bottle 212c contains a reagent having a specific composition. The reagents contained in the homogeneous reagent bottles 212c are recorded as homogeneous reagents, and for the homogeneous reagent bottles 212c on the same cassette 212a, the components of the homogeneous reagents contained in different homogeneous reagent bottles 212c are different. Homogeneous reagents are usually in solution. In the whole process that the reagent kit 212 rotates along with the rotating disc 211, the homogeneous reagent bottle 212c remains stationary in the cavity, and the homogeneous reagent bottle 212c does not rotate relative to the cassette body 212 a.
The number of the rotating reagent bottles 212b may be one, and the rotating reagent bottles 212b are placed in the most peripheral cavity of the cassette body 212a, which is closer to the mixing gear 213 than the other cavities. The rotating reagent bottle 212b contains a reagent in suspension, which is referred to as a solid-phase reagent for which the solid magnetic particles are in suspension. The rotating reagent bottle 212b may be cylindrical, and of course, the cavity for accommodating the rotating reagent bottle 212b may also be cylindrical, the rotating reagent bottle 212b is inserted into the cylindrical cavity, the transmission gear is connected to or installed at the bottom of the rotating reagent bottle 212b and located outside the cavity, the transmission gear is an external gear, the blending gear 213 may be an internal gear, the blending gear 213 is disposed around the turntable 211, and the transmission gear is engaged with the blending gear 213. Therefore, when the rotating shaft 214 drives the rotating disc 211 to rotate, the cassette body 212a rotates around the rotating shaft 214 following the rotation of the rotating disc 211, so that both the rotating reagent bottle 212b and the homogeneous reagent bottle 212c rotate around the rotating shaft 214, and meanwhile, since the transmission gear at the bottom of the rotating reagent bottle 212b is meshed with the blending gear 213, the blending gear 213 drives the rotating reagent bottle 212b to rotate around the central axis thereof relative to the cassette body 212a through the transmission gear, namely, the rotating reagent bottle 212b rotates in the cassette body 212 a.
Therefore, when the rotating shaft 214 drives the rotating disc 211 to rotate, the rotating reagent bottle 212b can simultaneously generate revolution and rotation, and the action of the revolution and rotation simultaneously causes the suspension in the rotating reagent bottle 212b to generate stronger oscillation, so that the solid-phase reagent in the suspension state forms turbulent flow, and finally the solid magnetic particles in the solid-phase reagent are always in the suspension state, i.e. the solid-phase reagent is uniformly mixed, so that the solid magnetic particles are prevented from being deposited at the bottom of the rotating reagent bottle 212b, and the solid-phase reagent subsequently extracted through the sampling needle contains a certain proportion of solid magnetic particles, thereby ensuring the accuracy of the subsequent test result. Since the homogeneous reagent bottle 212c contains the homogeneous reagent in a solution state, the homogeneous reagent bottle 212c does not need to be mixed uniformly.
Referring to fig. 6, the blending gear 213 is a circular gear, the blending gear 213 may be formed by splicing a plurality of circular arc-shaped racks 213a instead of an integrally formed processing method, and the circular arc-shaped racks 213a having a smaller size may reduce the manufacturing cost of a related mold or fixture, and may also reduce the processing difficulty, so that the processing precision and the processing efficiency of a single circular arc-shaped rack 213a may be easily ensured, and after the circular arc-shaped racks 213a are spliced to form the blending gear 213, the size and the form and position precision of the blended gear 213 may be well ensured. Therefore, by forming the kneading gear 213 by joining a plurality of circular arc-shaped racks 213a, which are easy to improve the processing accuracy and efficiency, the total manufacturing cost of the whole kneading gear 213 can be effectively reduced, and the processing efficiency and the processing accuracy of the kneading gear 213 can be improved.
Referring to both fig. 3 and 4, the driver 215 is positioned below the bottom cover 130 and the turntable 211 is positioned above the bottom cover 130 such that the driver 215 and the turntable 211 are on opposite sides of the bottom cover 130. The driver 215 comprises a supporting plate 140, a motor 215a, a driving wheel 215b, a driven wheel 215c and a timing belt 215d, wherein the motor 215a, the driving wheel 215b and the driven wheel 215c are all arranged on the supporting plate 140, and the supporting plate 140 plays a bearing and mounting role for the motor 215a, the driving wheel 215b and the driven wheel 215 c. The motor 215a may be a servo motor 215a or a stepping motor 215a, the motor 215a intermittently rotates, the rotating wheel is connected with the output shaft of the motor 215a, the driven wheel 215c is connected with the lower end of the rotating shaft 214, the synchronous belt 215d is sleeved on the driving wheel 215b and the driven wheel 215c, and the diameter of the driven wheel 215c is larger than that of the driving wheel 215b, so that the driven wheel 215c decelerates the motion output by the driving wheel 215b, and the torque of the driven wheel 215c is improved. When the motor 215a rotates, the turntable 211 can be driven to intermittently move by the rotating shaft 214, and when the motor 215a stops driving the turntable 211, the solid phase reagent and the homogeneous phase reagent can be sucked in the rotating reagent bottle 212b and the homogeneous phase reagent bottle 212c by the sampling needle for subsequent measurement and analysis. In some embodiments, the two rotating discs 211 independently and alternately transfer the target reagent cartridges 212 thereon to the positions below the corresponding sampling ports at regular intervals for the respective sampling needles to suck reagents. Therefore, the requirement on the rotating speed of the rotary table 211 can be further reduced, the requirement on the load of driving is further reduced, and the difficulty of driving control is reduced.
With the conventional reagent storage device 10, in order to increase the reagent storage capacity in response to a high test throughput (the number of test results per unit time), the total weight of the carousel 211 and the reagent cartridges 212 carried by the carousel 211 is increased by increasing the number of mounting positions on the carousel 211, and the load on the driver 215 is then excessive, which results in an increase in the difficulty of the driving control technique of the driver 215. In addition, since the turntable 211 is oversized, it is difficult to ensure its machining accuracy.
With the reagent storage device 10 in the above embodiment, by arranging two storage units 210 on the same pan body 100, that is, by arranging two rotary discs 211 in the accommodating cavity 101, as the number of the rotary discs 211 is increased, the total number of the mounting bits of the two rotary discs 211 is increased under the condition that the number of the mounting bits of a single rotary disc 211 is kept unchanged or even reduced, so that the carrying number of the reagent cartridges 212 in the whole reagent storage device 10 can be increased, thereby meeting the requirement of the test throughput. Therefore, the single rotary table 211 can be ensured to have a reasonable size, so that the processing precision of the rotary table 211 is ensured, and the total weight of the single rotary table 211 and the reagent boxes 212 carried by the rotary table 211 is in a reasonable value range, thereby effectively preventing the phenomenon that the difficulty of control technology is increased due to the overlarge load of the driver 215. Therefore, by using two rotating discs 211 to share one pan body 100, on the basis of increasing the total number of reagent kits 212 to adapt to the measured flux, not only each rotating disc 211 has a relatively reasonable size, but also the volume of the whole reagent storage device 10 is favorably reduced, so that the reagent storage device 10 is more compact in structure, and the difficulty in controlling the movement of the rotating discs 211 is reduced.
Because two independent storage units 210 are arranged, when one storage unit 210 fails, the other storage unit 210 can continue to work, so that the phenomenon that the conventional reagent storage device 10 cannot work completely due to the failure of one storage unit 210 is avoided, and the reliability and fault tolerance of the whole reagent storage device 10 are improved. Of course, in the case where one of the storage units 210 continues to operate, the storage unit 210 in which the failure occurred may be repaired to subsequently restore the state in which the two storage units 210 can be used simultaneously.
Referring to fig. 1, 2 and 7, in some embodiments, the refrigeration mechanism 300 includes a cold-end unit 310, a hot-end unit 320, a refrigeration sheet 330, a heat insulation plate 340 and a heat dissipation duct 323, where the cold-end unit 310 is located in the accommodating chamber 101, and the hot-end unit 320 and the heat dissipation duct 323 are located outside the accommodating chamber 101. The number of cold end units 310 is at least two, for example, the number of cold end units 310 is an even number divided into one or more pairs. The at least two cold end units 310 are symmetrically distributed in the accommodating cavity 101 along a connecting line of the centers of the at least two rotating discs 211 or a vertical middle dividing line of the connecting line of the centers of the at least two rotating discs 211. This not only helps to improve the cooling efficiency, but also helps to maintain the temperature uniformity at each point in the accommodating chamber 101. In one embodiment, referring to FIG. 5, the cold end units 310 are positioned in the gap between the two disks 211, symmetrically distributed along a line connecting the centers of the two disks 211. Therefore, the space between the two turntables 211 in the accommodating cavity 101 is fully utilized, the layout of the whole machine is facilitated, more parts can be accommodated in the limited accommodating cavity 101, and the size of the whole pot body 100 is reduced.
The cold end unit 310 comprises a cold end cooling fin 311, a cold end fan 312 and a mounting seat 313, the cold end cooling fin 311 is connected with the cold end of the refrigerating fin 330, the mounting seat 313 is connected with the cold end cooling fin 311 and abuts against the bottom cover 130 of the pot body 100, and the cold end fan 312 is fixed on the mounting seat 313. The hot end unit 320 comprises hot end heat sinks 321 and hot end fans 322, the hot end heat sinks 321 are connected with the bottom cover 130 of the pan body 100 and are used for absorbing the heat of the hot ends of the refrigeration sheets 330, and the number of the hot end fans 322 is at least two. When the number of the hot side fans 322 is two, the two hot side fans 322 are respectively fixed to both ends of the hot side heat sink 321. The heat-dissipating air passage 323 is connected to the end of the hot-side heat sink 321, the hot-side heat sink 321 is disposed around the hot-side fan 322, and the hot-side fan 322 exhausts the heat of the hot-side heat sink 321 from the heat-dissipating air passage 323. For the same hot-end unit 320, the number of the heat-dissipating air channels 323 may be two, that is, two ends of the hot-end heat-dissipating fins 321 are both connected with one heat-dissipating air channel 323, and certainly, the number of the heat-dissipating air channels 323 may be one, that is, only one end of the hot-end heat-dissipating fins 321 is connected with the heat-dissipating air channel 323. The heat dissipation air duct 323 is located below the pan body 100, so that the space on the peripheral side of the pan body 100 can be saved, and space is reserved for arrangement of other devices of the whole machine. Further, the heat dissipation duct 323 is located below the center of the pan body 100 and passes through the gap between the two drivers 215, which further saves the space of the whole device.
The bottom cover 130 may be formed with a through-hole in which the insulation plate 340 and the cooling plate 330 may be installed, so that the insulation plate 340 and the cooling plate 330 are sandwiched between the hot-side heat dissipation fin 321 and the cold-side heat dissipation fin 311. The cooling plate 330 may be a peltier cooling plate 330 made of a semiconductor material. When the refrigeration mechanism 300 operates, the cold end of the refrigeration sheet 330 generates refrigeration, and the refrigeration is transferred into the accommodating cavity 101 through the cold end cooling fin 311, the heat at the hot end of the refrigeration sheet 330 is transferred to the hot end cooling fin 321, and the hot end fan 322 can discharge the heat from the cooling air duct 323 to the outside. For the cold side fans 322 on the same pair of cold side units 310, the blowing direction is reversed. For example, the cold-end fan 312 on one of the cold-end units 310 is used for drawing air from the cold-end heat sink 311, and the cold-end fan 312 on the other cold-end unit 310 is used for supplying air to the cold-end heat sink 311, so that the air circulation in the accommodating chamber 101 can be accelerated, the refrigeration effect in the accommodating chamber 101 is improved, the same temperature is ensured in each space in the accommodating chamber 101, and all reagents in the reagent kit 212 are kept at the same temperature. In addition, the reagent cartridges 212 driven by the two rotating discs 211 rotate independently, so that air in the accommodating cavity 101 can be stirred, cold air flow is further accelerated, and temperature uniformity is kept.
Because two storage units 210 share one pot body 100, two rotary discs 211 are located in the accommodating cavity 101 in the same pot body 100, and the refrigerating mechanism 300 is connected with the pot body 100, when the refrigerating mechanism 300 generates a refrigerating effect to keep the accommodating cavity 101 at a set temperature (2-8 ℃), reagent boxes 212 on the two rotary discs 211 are located in a refrigerating environment (the accommodating cavity 101) with the same temperature, all reagent components in all the reagent boxes 212 are kept at the same temperature, so that the temperature consistency of reagents stored in the whole reagent storage device 10 is ensured, the influence on the reagent performance due to inconsistent temperature is reduced, and the accuracy of subsequent test results is ensured. Moreover, the two cold end units 310 share the same heat dissipation air duct 323, so that the number of the heat dissipation air ducts 323 can be reduced, and the reagent storage structure is more compact. Furthermore, the cold end unit 310 is located in the gap between the two turntables 211, and the hot end heat sink 321 is located below the cold end heat sink 311, which is more beneficial to the overall spatial layout of the hot end heat sink 321 and the heat dissipation air duct 323.
Referring to fig. 7, in some embodiments, the reagent storage device 10 further includes a scanner 400, and the scanner 400 is disposed on an inner wall surface of the side frame 110, so that the scanner 400 is located in the accommodating cavity 101 of the pot body 100, that is, the scanner 400 can fully utilize an existing installation space of the accommodating cavity 101, and does not occupy an installation space outside the accommodating cavity 101, thereby improving the compactness of the reagent storage device 10 in structure. The number of scanners 400 and the number of turrets 211 may be equal, i.e., one scanner 400 per turret 211. The scanner 400 is used to scan the barcode on the reagent cartridge 212, thereby identifying the barcode information on the reagent cartridge 212 to identify and distinguish the reagents of different analysis items. The fixed design of scanner 400, i.e., the fixed connection of scanner 400 directly to side frame 110, also results in a more compact reagent storage device 10 and reduced manufacturing costs.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (18)

1. A reagent storage device, comprising:
the pot body is provided with an accommodating cavity;
the storage mechanism comprises at least two storage units, each storage unit comprises a rotary disc and a reagent box, the rotary discs are positioned in the accommodating cavities and can rotate in the accommodating cavities, and the reagent boxes are arranged on the rotary discs and used for storing reagents; and
the refrigerating mechanism is connected with the pot body so as to keep the accommodating cavity at a set temperature.
2. The reagent storage device of claim 1, wherein the refrigeration mechanism comprises a cold end unit, a hot end unit and a refrigeration piece, the cold end unit is located in the accommodating cavity, the hot end unit is located outside the accommodating cavity, and one end of the cold end unit and one end of the hot end unit are respectively connected with the cold end and the hot end of the refrigeration piece.
3. The reagent storage device of claim 2 wherein the cold end units are symmetrically distributed within the housing chamber along a line joining the centers of at least two of the carousels or a perpendicular bisector of a line joining the centers of at least two carousels.
4. The reagent storage device of claim 2 wherein the cold end unit is located in a gap between two adjacent of the carousels, the cold end unit comprising a mount, a cold end heat sink and a cold end fan, the mount being disposed on the cold end heat sink and the cold end fan being disposed on the mount.
5. Reagent storage device according to claim 4 wherein the number of cold end units is an even number divided into at least one pair.
6. The reagent storage device of claim 5 wherein the cold end fans on each pair of cold end units blow air in opposite directions.
7. The reagent storage device of claim 2 wherein the hot side unit comprises a hot side heat sink and a hot side fan, the hot side heat sink being connected to the hot side of the chilling plate and configured to absorb heat from the hot side unit of the chilling plate, the hot side fan being disposed at each end of the hot side heat sink.
8. The reagent storage device of claim 7 wherein the hot side unit further comprises a heat sink air duct connected to an end of the hot side heat sink and disposed around the hot side fan, the hot side fan removing heat from the hot side heat sink from the heat sink air duct.
9. The reagent storage device of claim 8 wherein the heat dissipation duct is located below the pan body.
10. The reagent storage device of claim 1, wherein the pan body comprises a bottom cover, a top cover and side frames, the bottom cover and the top cover are respectively connected with two ends of the side frames, the bottom cover, the top cover and the side frames together enclose the accommodating cavity, the turntable is rotatably connected with the bottom cover, and the refrigeration mechanism is arranged on the bottom cover.
11. The reagent storage device of claim 10 wherein at least two sets of sample ports are provided on the top cover, each set of sample ports corresponding to one of the storage units.
12. The reagent storage device of claim 10 wherein the cross-sectional shape of the side frame is rectangular or racetrack.
13. The reagent storage device of claim 1 further comprising a scanner disposed on the pan body, the scanner being positioned within the receiving cavity and configured to identify barcode information on the reagent cartridge.
14. The reagent storage device of claim 1, wherein the storage unit further comprises a blending gear arranged around the turntable, the reagent kit comprises a kit body, a rotating reagent bottle and a transmission gear, the kit body is mounted on the turntable, the rotating reagent bottle is rotatably connected with the kit body, and the transmission gear is arranged on the rotating reagent bottle and meshed with the blending gear.
15. The reagent storage device of claim 1, wherein each of the storage units is loaded with all reagents required for a corresponding analysis item.
16. The reagent storage device of claim 1, wherein the storage unit further comprises a rotating shaft and a driver, the rotating shaft is arranged in the pot body in a penetrating manner and connected with the rotary disc, and the driver is positioned outside the accommodating cavity and drives the rotating shaft to rotate.
17. The reagent storage device of claim 16 wherein the driver comprises a motor, a drive wheel, a driven wheel and a synchronous belt, the drive wheel is connected to the motor, the driven wheel is disposed on the shaft, and the synchronous belt is sleeved on the drive wheel and the driven wheel.
18. The reagent storage device of claim 16 wherein the refrigeration mechanism includes a heat dissipation duct for heat removal, the heat dissipation duct passing through a gap between the two drives.
CN202010323370.4A 2020-04-22 2020-04-22 Reagent storage device Pending CN113533762A (en)

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JPH0754326B2 (en) * 1986-06-24 1995-06-07 株式会社東芝 Automatic chemical analyzer
US7842504B2 (en) * 2004-04-02 2010-11-30 Siemens Healthcare Diagnostics Inc. Method for increasing throughput in an automatic clinical analyzer by duplicating reagent resources
JP2009288094A (en) * 2008-05-29 2009-12-10 Toshiba Corp Automatic analyzer
JP6651443B2 (en) * 2013-10-17 2020-02-19 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドSiemens Healthcare Diagnostics Inc. Basic structure of a compact, high-capacity analytical instrument
CN108195118A (en) * 2018-01-31 2018-06-22 深圳迎凯生物科技有限公司 Reagent storage means
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CN212134719U (en) * 2020-04-22 2020-12-11 深圳迎凯生物科技有限公司 Reagent storage device

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