CN112890812A - Method, device and system for checking effectiveness of near infrared spectrum imaging equipment - Google Patents
Method, device and system for checking effectiveness of near infrared spectrum imaging equipment Download PDFInfo
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- CN112890812A CN112890812A CN202110194395.3A CN202110194395A CN112890812A CN 112890812 A CN112890812 A CN 112890812A CN 202110194395 A CN202110194395 A CN 202110194395A CN 112890812 A CN112890812 A CN 112890812A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
Abstract
The embodiment of the disclosure provides a method, a device and a system for checking the effectiveness of near infrared spectrum imaging equipment, wherein the near infrared spectrum imaging equipment comprises a transmitting probe, a receiving probe, a display and a processor, and the method comprises the following steps: acquiring a first light intensity signal, wherein the first light intensity signal is transmitted by a transmitting probe and is detected by a receiving probe after being absorbed by water; acquiring a second light intensity signal, wherein the second light intensity signal is transmitted by the transmitting probe and is absorbed by the light absorption solution and then detected by the receiving probe; calculating the relative variation of absorbance according to the first light intensity signal and the second light intensity signal; wherein the water and the light absorbing solution are located in and not in contact with the gel, the gel is used to simulate human tissue, and the light absorbing solution is used to simulate blood in a human blood vessel. The method can accurately, effectively and quantitatively demonstrate the effectiveness of the near infrared spectrum imaging equipment, and is simple, convenient, easy to operate and high in universality.
Description
Technical Field
The present disclosure relates to the field of medical device inspection technologies, and in particular, to a method, an apparatus, and a system for inspecting the effectiveness of a near infrared spectroscopy imaging device.
Background
The near infrared spectrum imaging device is an advanced medical device which is noninvasive, portable in use and capable of meeting requirements of various scenes, and is widely applied to various fields. The basic measurement principle is as follows: a pair of transmitting-receiving probes are arranged on the surface of the tissue to be detected at a certain distance to form a detection channel, the concentration of hemoglobin in the tissue changes along with the change of metabolism and oxygen consumption level, which causes the change of optical signals measured by the pair of transmitting-receiving probes, and the change of the concentration of hemoglobin in the tissue can be calculated according to the change of the signals in the optical channel.
In the prior art, a common method for verifying the effectiveness of near infrared spectrum imaging equipment is to select a subject to execute a classical manual paradigm and judge the quality of the performance of the equipment by observing whether an experiment obtains an expected response or not. In addition, the method is used for demonstrating the measurement effectiveness of the near infrared spectrum imaging equipment through fMRI (functional magnetic resonance imaging) and near infrared spectrum imaging equipment synchronous combined experiments, and the method is high in test cost, large in development difficulty and high in cost. Except for the above test method, the performance test for the near infrared spectrum imaging device mostly stays in the aspects of physical parameters such as power, spectrum, sampling rate and the like, and the parameters are only used as the physical parameter performance of the device, so that the fact that the device has the performance of measuring the hemoglobin concentration variation cannot be demonstrated.
Therefore, an accurate, effective and quantitative test method is not available to demonstrate the basic function of measuring the hemoglobin concentration variation of the near infrared spectrum imaging device.
Disclosure of Invention
The method can accurately, effectively and quantitatively demonstrate the effectiveness of the near infrared spectrum imaging equipment, and is simple, convenient and easy to operate.
The disclosed embodiments provide a method of verifying the validity of a near infrared spectroscopy imaging apparatus comprising a transmitting probe, a receiving probe, a display and a processor, the method comprising:
acquiring a first light intensity signal, wherein the first light intensity signal is emitted by the emitting probe and is detected by the receiving probe after being absorbed by water;
acquiring a second light intensity signal, wherein the second light intensity signal is emitted by the emission probe and is absorbed by a light absorption solution and then detected by the receiving probe;
calculating the relative variation of absorbance according to the first light intensity signal and the second light intensity signal; wherein the content of the first and second substances,
the water and the light absorbing solution are located in and not in contact with a gel that simulates human tissue and the light absorbing solution simulates blood in a human blood vessel.
In some embodiments, the method further comprises:
acquiring a plurality of second light intensity signals, wherein the plurality of second light intensity signals correspond to light absorption solutions with different concentrations respectively;
calculating the absorbance relative variation corresponding to the light absorption solutions with different concentrations according to the first light intensity signal and the plurality of second light intensity signals;
and performing linear fitting on the concentration numerical values of the multiple groups of light absorption solutions and the absorbance relative change numerical values corresponding to the concentration numerical values, and evaluating the linearity of the near infrared spectrum imaging equipment for measuring the hemoglobin change amount in the tissue according to the linear fitting result.
In some embodiments, the gel is formed from agar powder, intralipid (inflixilipide), and water.
In some embodiments, the light absorbing solution is an ink solution.
The disclosed embodiments also provide an apparatus for verifying the validity of a near infrared spectral imaging device, the apparatus comprising:
a container carrying a gel for simulating human tissue;
a fixing member installed on an inner wall of the container, the fixing member having a pipe fixed thereto, wherein a portion of the pipe is immersed in the gel, and an inlet and an outlet of the pipe are extended out of the container to inject a liquid into the pipe; wherein the content of the first and second substances,
and two mounting holes are formed in the side wall of the container, correspond to the two ends of the partial pipeline respectively, and are matched with the transmitting probe and the receiving probe of the near infrared spectrum imaging equipment respectively.
In some embodiments, the conduit is a transparent conduit that is used to simulate a blood vessel of a human body.
In some embodiments, the partial pipe is in a spiral shape, the spiral shape of the partial pipe being disposed facing the side wall of the container, and
the spiral center of the partial pipeline and the center of the mounting hole are positioned on the same horizontal line.
In some embodiments, the container is made of a light-tight material; or
The device also includes a light shield that can receive the container and the duct to form a light-tight space.
In some embodiments, the relative distance between the mounting hole and the portion of the conduit is in the range of 0.5cm to 8 cm.
The embodiment of the present disclosure further provides a system for checking validity of a near infrared spectrum imaging device, the system includes any one of the above devices for checking validity of a near infrared spectrum imaging device and a monitoring station, wherein the monitoring station includes:
a communication interface configured to receive a light intensity signal detected by a receiving probe of a near infrared spectroscopy imaging apparatus;
a processor configured to calculate the relative variation of absorbance according to the light intensity signal and obtain a test result;
a display configured to present the inspection result.
Compared with the prior art, the beneficial effects of the embodiment of the present disclosure are that: according to the method, the device and the system for checking the effectiveness of the near infrared spectrum imaging equipment, gel is used for simulating human body tissues, the pipeline is used for simulating blood vessels of a human body, the light absorption solution is used for simulating blood in the blood vessels of the human body, the relative variation of absorbance is calculated by respectively detecting light intensity signals absorbed by water and the light absorption solution, and the effectiveness of the near infrared spectrum imaging equipment is checked according to the relative variation of absorbance. The method can simulate the scene of the near infrared spectrum imaging device when the blood oxygen change in human tissues is actually measured, the effectiveness of the near infrared spectrum imaging device is checked by calculating the absorbance relative change, the effectiveness of the near infrared spectrum imaging device can be accurately, effectively and quantitatively demonstrated, and the method is simple, convenient, easy to operate and high in universality.
Drawings
In the drawings, which are not necessarily drawn to scale, like reference numerals may describe similar components in different views. Like reference numerals having letter suffixes or different letter suffixes may represent different instances of similar components. The drawings illustrate various embodiments generally by way of example and not by way of limitation, and together with the description and claims serve to explain the disclosed embodiments. The same reference numbers will be used throughout the drawings to refer to the same or like parts, where appropriate. Such embodiments are illustrative, and are not intended to be exhaustive or exclusive embodiments of the present apparatus or method.
FIG. 1 is a flow chart of a method of verifying the effectiveness of a near infrared spectral imaging device according to an embodiment of the present disclosure;
FIG. 2 is a front view of an apparatus for verifying the effectiveness of a near infrared spectral imaging device according to an embodiment of the present disclosure;
FIG. 3 is a top view of an apparatus for verifying the effectiveness of a near infrared spectral imaging device according to an embodiment of the present disclosure.
The members denoted by reference numerals in the drawings:
1-a container; 2-gel; 3-a fixing piece; 4-a pipeline; 41-part of pipeline; 42-an inlet; 43-an outlet; 5-transmitting the probe; 6-receiving the probe.
Detailed Description
For a better understanding of the technical aspects of the present disclosure, reference is made to the following detailed description taken in conjunction with the accompanying drawings. Embodiments of the present disclosure are described in further detail below with reference to the figures and the detailed description, but the present disclosure is not limited thereto.
The use of "first," "second," and similar terms in this disclosure is not intended to indicate any order, quantity, or importance, but rather are used to distinguish one element from another. The word "comprising" or "comprises", and the like, means that the element preceding the word covers the element listed after the word, and does not exclude the possibility that other elements are also covered. "upper", "lower", "left", "right", and the like are used merely to indicate relative positional relationships, and when the absolute position of the object being described is changed, the relative positional relationships may also be changed accordingly.
In the present disclosure, when a specific device is described as being located between a first device and a second device, there may or may not be intervening devices between the specific device and the first device or the second device. When a particular device is described as being coupled to other devices, that particular device may be directly coupled to the other devices without intervening devices or may be directly coupled to the other devices with intervening devices.
All terms (including technical or scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs unless specifically defined otherwise. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
Techniques, methods, and apparatus known to those of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate.
The embodiment of the disclosure provides a method for checking effectiveness of near infrared spectrum imaging equipment, which can check consistency and linearity of hemoglobin variation measurement in a tissue by the near infrared spectrum imaging equipment, wherein the near infrared spectrum imaging equipment comprises an emission probe, a receiving probe, a display and a processor, the emission probe is used for emitting incident light to human tissue, the receiving probe receives emergent light and transmits the emergent light signal to the processor for processing through a communication interface, hemoglobin concentration variation inside the tissue is obtained, and a processing result is presented through the display. As shown in fig. 1, the method includes:
s101, acquiring a first light intensity signal, wherein the first light intensity signal is emitted by an emitting probe and is detected by a receiving probe after being absorbed by water;
s102, acquiring a second light intensity signal, wherein the second light intensity signal is emitted by the emission probe and is absorbed by the light absorption solution and then detected by the receiving probe;
s103, calculating the relative variation of absorbance according to the first light intensity signal and the second light intensity signal; wherein the water and the light absorbing solution are located in and not in contact with the gel, the gel is used to simulate human tissue, and the light absorbing solution is used to simulate blood in a human blood vessel.
It can be understood that the method can simulate human body environment, the gel is used for simulating human body tissues, and the light absorption solution is used for simulating blood in human body blood vessels, so that the method realizes the detection on the effectiveness of the near infrared spectrum imaging equipment in the simulated human body environment, and can ensure the effectiveness and the accuracy of a detection result.
It can be understood that the gel has better stability, and the use of the gel to simulate human tissue can ensure that no additional movement interference is introduced in the test process, so that the validity and accuracy of the test result can be ensured, and if the aqueous solution is used to simulate human tissue, the aqueous solution can flow in the test process to influence the test result. It is understood that there are various methods for preparing the gel, as long as the obtained gel can simulate human tissues, and the technical scheme is not particularly limited, for example, the gel can be prepared from various materials such as milk, starch, fat emulsion, etc.
It can be understood that, in step S103, the relative variation of absorbance may be obtained by calculating the ratio of the first light intensity signal and the second light intensity signal, and the effectiveness of the near infrared spectrum imaging device may be checked according to the relative variation of absorbance, so that accurate, effective and quantitative demonstration of the effectiveness of the near infrared spectrum imaging device may be implemented, and the method is simple and easy to implement.
In some embodiments, the method may be used to verify the effectiveness of different channels on the same near-infrared spectroscopy imaging apparatus in measuring the amount of change in hemoglobin concentration in tissue, wherein the light intensity signal of one channel is measured by a pair of transmit-receive probes, for example, to verify the consistency of the various channels of the near-infrared spectroscopy imaging apparatus based on the relative amount of change in absorbance of the different channels with respect to a light absorbing solution of the same concentration.
It can be understood that the method has higher universality. In some embodiments, the method may be used to verify the validity of different models and manufacturers of near infrared spectroscopy imaging equipment, for example, the validity of each near infrared spectroscopy imaging equipment is verified based on the relative change in absorbance of the different equipment relative to a light absorbing solution of the same concentration.
It is understood that the light absorbing solution may be any solution having a light absorbing function, for example, an ink solution or other solution having a significant absorption in the near infrared spectrum, and is not particularly limited herein.
The method for checking the effectiveness of the near infrared spectrum imaging equipment provided by the embodiment of the disclosure utilizes gel to simulate human body tissues, the light absorption solution simulates blood in human body blood vessels, the relative variation of absorbance is calculated by respectively detecting light intensity signals absorbed by water and the light absorption solution, and the effectiveness of the near infrared spectrum imaging equipment is checked according to the relative variation of absorbance.
In some embodiments, the method further comprises: acquiring a plurality of second light intensity signals, wherein the plurality of second light intensity signals correspond to light absorption solutions with different concentrations respectively; respectively calculating the absorbance relative change quantity corresponding to the light absorption solutions with different concentrations according to the first light intensity signal and the plurality of second light intensity signals; and performing linear fitting on the concentration numerical values of the multiple groups of light absorption solutions and the absorbance relative change numerical values corresponding to the concentration numerical values, and evaluating the linearity of the near infrared spectrum imaging equipment for measuring the hemoglobin change amount in the tissue according to the linear fitting result.
Specifically, the linearity of the near infrared spectrum imaging device for measuring the hemoglobin variation in the tissue is the basis for the device to be able to quantitatively measure the hemoglobin variation in the tissue, and if the linearity is poor, it indicates that the device is inaccurate in measuring the hemoglobin concentration variation, which means that the device cannot claim that the device has the function of measuring the hemoglobin concentration variation.
The absorption degree that different concentrations's extinction solution was set light is different, when the evaluation near infrared spectrum imaging device was to the linearity that hemoglobin variation measured in the tissue, can be according to the second light intensity signal after the extinction solution absorption of first light intensity signal and receiving probe detection via different concentrations, calculate the absorbance relative change volume that different concentrations's extinction solution corresponds, then carry out linear fitting according to the concentration numerical value of extinction solution and its absorbance relative change volume that corresponds, obtain the fitting curve, come to evaluate the linearity that hemoglobin variation measured in the tissue to equipment according to this fitting curve.
In some embodiments, the fitted curve and the standard curve may be compared, and the linearity of the device may be quantitatively evaluated according to the comparison result, where the standard curve may be obtained by fitting the concentration values of the multiple sets of light-absorbing solutions under ideal conditions and the corresponding variation amounts of absorbance.
It will be appreciated that the gel is formed by mixing agar powder, intralipid (inflixipide) and water. In a specific embodiment, the gel is formed by mixing 1.5% of agar powder, 1% of intralipid and 97.5% of water, the gel prepared according to the proportion has optical parameters close to human tissues, can better simulate the human tissues, has better stability, and can ensure that no additional motion interference is introduced in the inspection process, thereby ensuring the validity and accuracy of the inspection result.
In some embodiments, the light absorbing solution is an ink solution, for example, an indian ink solution. Particularly, the ink solution is non-toxic and harmless, harmful substances cannot be generated in the testing process, no dangerous factors can be introduced, the ink solution is simple in configuration, the pure water is used for diluting according to a specific proportion to obtain a specific concentration, in addition, the light absorption performance of the ink solution in the near infrared spectrum range is obvious, and a good measuring effect can be achieved.
The disclosed embodiments also provide an apparatus for verifying the validity of a near infrared spectral imaging device, as shown in fig. 2-3, the apparatus comprising: a container 1 carrying a gel 2, the gel 2 being for simulating human tissue; a holder 3 mounted on the inner wall of the container 1, the holder 3 having a tube 4 fixed thereto, the tube 4 being for carrying water and a light-absorbing solution, wherein a portion of the tube 41 is immersed in the gel 2 and an inlet 42 and an outlet 43 of the tube 4 both extend out of the container 1 for injecting liquid into the tube 4; wherein, the sidewall of the container 1 is provided with two mounting holes (not shown in the figure), the two mounting holes respectively correspond to two ends of a part of the pipeline 41, and the two mounting holes are respectively matched with the transmitting probe 5 and the receiving probe 6 of the near infrared spectrum imaging device, so as to mount the transmitting probe 5 and the receiving probe 6 on the sidewall of the container 1 (as shown in fig. 2) during the inspection.
Specifically, as shown in fig. 2, the partial pipe 41 is completely immersed in the gel 2, and the positions of the transmitting probe 5 and the receiving probe 6 are also relatively lower than the liquid level of the gel 2 in the container 1, so as to ensure the validity and accuracy of the test result. When the device is used for checking the effectiveness of the near infrared spectrum imaging device, the transmitting probe 5 and the receiving probe 6 of the near infrared spectrum imaging device are respectively arranged on the mounting holes on the container 1, firstly, water is injected into the pipeline 4 through the inlet 42 of the pipeline 4, the transmitting probe 5 transmits a first light intensity signal to a part of the pipeline 4, the first light intensity signal is detected by the receiving probe 6 after being absorbed by water in a part of the pipeline 41, preferably, pure water is adopted here, then light absorption solution is injected into a part of the pipeline 41, a second light intensity signal is transmitted to a part of the pipeline 41 by the transmitting probe 5, the second light intensity signal is detected by the receiving probe 6 after being absorbed by the light absorption solution in a part of the pipeline 41, finally, the relative variation of absorbance is obtained by calculating the ratio of the first light intensity signal and the second light intensity signal, and the effectiveness of the near infrared spectrum imaging device is accurately checked according to the relative variation of, And (3) effective and quantitative demonstration.
It is understood that the first light intensity signal and the second light intensity signal may be selected when the light intensity signals are stable after a period of time.
In some embodiments, the tube 4 may be made of a soft material or a glass material. It can be understood that the pipe 4 with a smaller aperture size can be adopted, so that the injected water does not need to be discharged separately in the test process, and the water in the pipe 4 can be directly pushed forward when the light absorption solution is injected until the light absorption solution completely occupies the space of the pipe 41, so that the operation steps can be reduced, and the water in the pipe 4 can be prevented from diluting the light absorption solution to influence the accuracy of the test result.
It is understood that there are various methods for preparing the gel 2, as long as the obtained gel 2 can simulate human tissues, and the technical solution is not limited in particular, and for example, the gel 2 can be prepared from various materials such as milk, starch, fat emulsion, etc. In a specific embodiment, the gel 2 is formed by mixing 1.5% of agar powder, 1% of intralipid (inflixipide) and 97.5% of water, and the gel 2 obtained by mixing according to the proportion has good stability, can better simulate human tissues, and further ensures the validity and accuracy of a test result.
It is understood that the light absorbing solution may be any solution having a light absorbing function, for example, an ink solution or other solution having a significant absorption in the near infrared spectrum, and is not particularly limited herein.
The device for checking the effectiveness of the near infrared spectrum imaging equipment provided by the embodiment of the disclosure utilizes gel 2 to simulate human tissue, pipeline 4 simulates blood vessels in the human tissue, light absorption solution simulates blood in the human tissue, the relative variation of absorbance is calculated by respectively detecting light intensity signals absorbed by water and the light absorption solution, the effectiveness of the near infrared spectrum imaging equipment is checked according to the relative variation of absorbance, the device can simulate the scene of the near infrared spectrum imaging equipment when the blood oxygen in the human tissue is actually measured, the effectiveness of the near infrared spectrum imaging equipment is accurately, effectively and quantitatively demonstrated, the structure is simple, the operation is easy, the universality is high, and the device can be used for checking the effectiveness of the near infrared spectrum imaging equipment produced by different manufacturers in different models.
In some embodiments, the tube 4 is a transparent tube, which is used to simulate a blood vessel of a human body.
In some embodiments, the partial pipe 41 has a spiral shape (as shown in fig. 2), the spiral-shaped partial pipe 41 is disposed facing the sidewall of the container 1, and the spiral center of the partial pipe 41 is located on the same horizontal line as the center of the installation hole. It can be understood that the partial pipe 41 is designed into a symmetrical spiral shape (as shown in fig. 2), so that more part of the light received in the receiving probe 6 passes through the partial pipe 41, the coverage ratio of the partial pipe 41 in the light path is increased, and the inspection sensitivity of the device can be improved. It is understood that the coverage of the partial pipe 41 in the optical path can be improved by disposing the spiral center of the partial pipe 41 to be on the same horizontal line as the center of the installation hole.
In some embodiments, the container 1 is made of a light-tight material; or the device further comprises a light shield which can accommodate the container 1 and the duct 4 to form a light-tight space. The container 1 is designed to be made of opaque materials or a light shield is arranged to completely cover the container 1 and the pipeline 4 so as to avoid interference of external light in the test process and influence on effectiveness and accuracy of inspection.
As shown in fig. 3, the mounting hole is at a certain relative distance from a portion of the conduit 41 in the gel 2. In some embodiments, the relative distance between the mounting hole and the partial pipe 41 ranges from 0.5cm to 8cm, and the relative distance is used for simulating the distance between the position of hemoglobin concentration which can be detected by the probe when the human tissue is detected by the near infrared spectrum imaging device and the probe, namely simulating the depth from the hemoglobin concentration change part in the human tissue to the probe, so that the validity and the accuracy of the detection result can be further ensured.
The disclosed embodiment also provides a system for checking the validity of a near infrared spectrum imaging device, the system comprising the apparatus for checking the validity of a near infrared spectrum imaging device as described in any one of the above and a monitoring station, wherein the monitoring station comprises: a communication interface configured to receive a light intensity signal detected by a receiving probe of a near infrared spectroscopy imaging apparatus; a processor configured to calculate the relative variation of absorbance according to the detected light intensity signal and obtain a test result; a display configured to present the inspection result. Specifically speaking, the monitoring station is used for calculating the absorbance relative change according to the light intensity signal detected by the receiving probe so as to obtain the detection result, and the display can adopt various forms such as images and data tables to present the detection result, so that the detection result is simple and visual and is easy to understand.
It will be appreciated that the monitoring station also includes a memory having stored thereon computer-executable instructions for processing the received light intensity signals, calculating the relative amount of change in absorbance, and the like.
The system for checking the effectiveness of the near infrared spectrum imaging equipment provided by the embodiment of the disclosure utilizes gel to simulate human body tissues, pipelines simulate blood vessels in the human body tissues, light absorption solution simulates blood in the human body vessels, the relative variation of absorbance is calculated by respectively detecting light intensity signals absorbed by water and the light absorption solution, the effectiveness of the near infrared spectrum imaging equipment is checked according to the relative variation of absorbance, the system can simulate scenes of the near infrared spectrum imaging equipment when the blood oxygen in the human body tissues is actually measured, the effectiveness of the near infrared spectrum imaging equipment is accurately, effectively and quantitatively demonstrated, the system is simple in structure, easy to operate and high in universality, and can be used for checking the effectiveness of the near infrared spectrum imaging equipment produced by different models and different manufacturers.
Moreover, although exemplary embodiments have been described herein, the scope thereof includes any and all embodiments based on the disclosure with equivalent elements, modifications, omissions, combinations (e.g., of various embodiments across), adaptations or alterations. The elements of the claims are to be interpreted broadly based on the language employed in the claims and not limited to examples described in the present specification or during the prosecution of the application, which examples are to be construed as non-exclusive. It is intended, therefore, that the specification and examples be considered as exemplary only, with a true scope and spirit being indicated by the following claims and their full scope of equivalents.
The above description is intended to be illustrative and not restrictive. For example, the above-described examples (or one or more versions thereof) may be used in combination with each other. For example, other embodiments may be used by those of ordinary skill in the art upon reading the above description. In addition, in the foregoing detailed description, various features may be grouped together to streamline the disclosure. This should not be interpreted as an intention that a disclosed feature not claimed is essential to any claim. Rather, the subject matter of the present disclosure may lie in less than all features of a particular disclosed embodiment. Thus, the following claims are hereby incorporated into the detailed description as examples or embodiments, with each claim standing on its own as a separate embodiment, and it is contemplated that these embodiments may be combined with each other in various combinations or permutations. The scope of the disclosure should be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled.
The above embodiments are merely exemplary embodiments of the present disclosure, which is not intended to limit the present disclosure, and the scope of the present disclosure is defined by the claims. Various modifications and equivalents of the disclosure may occur to those skilled in the art within the spirit and scope of the disclosure, and such modifications and equivalents are considered to be within the scope of the disclosure.
Claims (10)
1. A method of verifying the validity of a near infrared spectroscopy imaging apparatus comprising a transmitting probe, a receiving probe, a display and a processor, the method comprising:
acquiring a first light intensity signal, wherein the first light intensity signal is emitted by the emitting probe and is detected by the receiving probe after being absorbed by water;
acquiring a second light intensity signal, wherein the second light intensity signal is emitted by the emission probe and is absorbed by a light absorption solution and then detected by the receiving probe;
calculating the relative variation of absorbance according to the first light intensity signal and the second light intensity signal; wherein the content of the first and second substances,
the water and the light absorbing solution are located in and not in contact with a gel that simulates human tissue and the light absorbing solution simulates blood in a human blood vessel.
2. The method of claim 1, further comprising:
acquiring a plurality of second light intensity signals, wherein the plurality of second light intensity signals correspond to light absorption solutions with different concentrations respectively;
calculating the absorbance relative variation corresponding to the light absorption solutions with different concentrations according to the first light intensity signal and the plurality of second light intensity signals;
and performing linear fitting on the concentration numerical values of the multiple groups of light absorption solutions and the absorbance relative change numerical values corresponding to the concentration numerical values, and evaluating the linearity of the near infrared spectrum imaging equipment for measuring the hemoglobin change amount in the tissue according to the linear fitting result.
3. The method of claim 1, wherein the gel is formed by mixing agar powder, intralipid (inflixilipide), and water.
4. The method of claim 1, wherein the light absorbing solution is an ink solution.
5. An apparatus for verifying the validity of a near infrared spectral imaging device, the apparatus comprising:
a container carrying a gel for simulating human tissue;
a fixing member installed on an inner wall of the container, the fixing member having a pipe fixed thereto, wherein a portion of the pipe is immersed in the gel, and an inlet and an outlet of the pipe are extended out of the container to inject a liquid into the pipe; wherein the content of the first and second substances,
and two mounting holes are formed in the side wall of the container, correspond to the two ends of the partial pipeline respectively, and are matched with the transmitting probe and the receiving probe of the near infrared spectrum imaging equipment respectively.
6. The device of claim 5, wherein the conduit is a transparent conduit configured to simulate a blood vessel of a human body.
7. The device according to claim 5, wherein the partial pipe is in the shape of a spiral, the spiral shaped partial pipe being arranged facing the side wall of the container, and
the spiral center of the partial pipeline and the center of the mounting hole are positioned on the same horizontal line.
8. The apparatus of claim 5, wherein the container is made of a light-impermeable material; or
The device also includes a light shield that can receive the container and the duct to form a light-tight space.
9. The apparatus of claim 5, wherein the mounting hole is located at a relative distance from the portion of tubing in a range of 0.5cm to 8 cm.
10. A system for checking the validity of a near infrared spectral imaging apparatus, characterized in that it comprises a device for checking the validity of a near infrared spectral imaging apparatus according to any one of claims 5 to 9 and a monitoring station, wherein said monitoring station comprises:
a communication interface configured to receive a light intensity signal detected by a receiving probe of a near infrared spectroscopy imaging apparatus;
a processor configured to calculate the relative variation of absorbance according to the light intensity signal and obtain a test result;
a display configured to present the inspection result.
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