CN111990410A - Hypochlorous acid disinfectant, preparation method thereof and preparation method of disinfectant wet tissue - Google Patents
Hypochlorous acid disinfectant, preparation method thereof and preparation method of disinfectant wet tissue Download PDFInfo
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- CN111990410A CN111990410A CN202010912456.0A CN202010912456A CN111990410A CN 111990410 A CN111990410 A CN 111990410A CN 202010912456 A CN202010912456 A CN 202010912456A CN 111990410 A CN111990410 A CN 111990410A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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Abstract
The invention relates to a hypochlorous acid disinfectant, a preparation method thereof and a preparation method of a disinfectant wet tissue, wherein the hypochlorous acid disinfectant comprises the following components in parts by weight: 70-80 parts of EDI ultrapure water; 15-30 parts of hypochlorous acid generating agent; 6-12 parts of a stabilizer; 4.5-9 parts of a carbon dioxide generating agent; the hypochlorous acid disinfectant disclosed by the invention is low in smell, free of corrosiveness and wide in application range, can be safely used for air disinfection, object surface disinfection, hand disinfection, skin disinfection, medical appliances and the like, belongs to a high-level disinfectant, is low in using concentration, can achieve the effect of killing bacteria, viruses and the like only by 100ppm, and is very quick in effect of killing novel coronaviruses.
Description
Technical Field
The invention relates to the technical field of disinfection products, in particular to hypochlorous acid disinfectant, a preparation method thereof and a preparation method of disinfection wet tissues.
Background
In recent years, the disinfection of medical institution object surfaces and medical equipment has been gradually replaced by wet wipes of the disinfection type for the following reasons, first: the disinfection mode of the traditional type is to dip the disinfectant with gauze, the disinfectant needs to be diluted first when in use, the process is time-consuming and labor-consuming, the concentration dilution ratio is slightly not thorough, the disinfection is easy to cause, and the infection risk exists. Secondly, the gauze after being used is treated to cause a large amount of medical waste, which is very unfavorable for the environmental protection policy advocated by the state.
In the aspect of supervision of disinfection products in the market at present, there are so several concepts, wet tissue, sanitary wet tissue, disinfection wet tissue, wherein, wet tissue does not have the disinfection effect, sanitary wet tissue can reach low level disinfection effect, along with the development of novel coronavirus epidemic situation, disinfection wet tissue gradually appears in medical institution and people's field of vision, the composition is mainly 75% ethanol composition, quaternary ammonium salt composition, hydrogen peroxide composition etc. 75% ethanol is used as disinfectant alone, can reach the disinfection of level, hydrogen peroxide can reach high level disinfection when the addition reaches more than 5%, but the skin can be burnt to high concentration hydrogen peroxide.
The hypochlorous acid products on the market currently are mostly liquid preparations, are mainly used for hand disinfection, but are few in wet tissue products, because the stability of the hypochlorous acid factor is difficult to achieve, the hypochlorous acid disinfection factor can react with components and materials on a carrier, the stability of the hypochlorous acid disinfectant is poor, the shelf life of the traditional hypochlorous acid disinfectant can only reach the validity period of 3 months, and the traditional hypochlorous acid disinfectant needs to be under a closed condition.
Disclosure of Invention
In order to solve the defects in the prior art, the invention aims to provide a hypochlorous acid disinfectant, a preparation method thereof and a preparation method of a disinfectant wet tissue, which can improve the unstable factors of hypochlorous acid disinfectant products.
The technical scheme adopted by the invention for solving the technical problems is as follows:
the hypochlorous acid disinfectant is characterized by comprising the following components in parts by weight:
70-80 parts of EDI ultrapure water;
15-30 parts of hypochlorous acid generating agent;
6-12 parts of a stabilizer;
4.5-9 parts of a carbon dioxide generating agent.
The hypochlorous acid generating agent comprises the following components in parts by weight:
5-10 parts of hydrochloric acid;
10-20 parts of sodium hypochlorite.
The stabilizer comprises the following components in parts by weight:
3-6 parts of potassium bromide;
3-6 parts of sodium bromide.
The carbon dioxide generating agent comprises the following components in parts by weight:
4-6 parts of sodium carbonate;
0.5-3 parts of sodium bicarbonate.
The preparation method of the hypochlorous acid disinfectant is characterized by comprising the following steps of:
step 1, opening a material preparation tank, setting the temperature to 20-40 ℃, adding EDI ultrapure water, starting stirring, sequentially adding sodium carbonate and sodium bicarbonate, adding 10% dilute hydrochloric acid solution after the components are fully dissolved, and fully stirring for 2-3 hours;
step 2, adding potassium bromide and sodium bromide into a batching tank to fully dissolve the potassium bromide and the sodium bromide;
step 3, adding sodium hypochlorite into the batching tank, and adjusting the pH value of the solution to 5.5-6.5;
and 4, generating a hypochlorous acid solution in the batching tank, wherein the concentration range of the hypochlorous acid solution is between 85ppm and 220 ppm.
The batching jar adopts vacuum homogeneity emulsification jar.
The preparation method of the disinfectant wet tissue is characterized by comprising the following steps:
step 1, carrying out anti-oxidation treatment on melt-blown cloth for manufacturing the wet tissue through an antioxidant, and drying at 35-37 ℃;
and 2, fully-closed spraying is adopted by the spraying device during spraying, and carbon dioxide is continuously introduced into the closed space.
Further, the method also comprises the following steps:
and 3, filling the sterilized wet tissue into an outer package, and spraying a silver ion spraying film on the inner wall of the outer package.
The antioxidant is a mixture of tea polyphenol and phytic acid, and the addition ratio of the tea polyphenol to the phytic acid is 2-4: 1; mixing the antioxidants, and dissolving with anhydrous ethanol at a ratio of ethanol to antioxidant of 2-3: 1.
The invention has the beneficial effects that:
the hypochlorous acid disinfectant has low smell, no corrosion and wide application, can be safely used for air disinfection, object surface disinfection, hand disinfection, skin disinfection, medical appliances and the like, belongs to a high-level disinfectant, has low use concentration, can achieve the effect of killing bacteria, viruses and the like only by 100ppm, and has very quick effect of killing novel coronaviruses.
The disinfection wet tissue has good stability, the effective period can be as long as two years, the content reduction rate is less than or equal to 10 percent, the disinfection wet tissue completely meets the requirement of national standard in the disinfection industry, and based on the fact that the product is basically in a blank state in the market, on the basis of overcoming the stability of the product and being capable of being stored for two years, the disinfection factor fills the blank in the field of wet tissue that the medical disinfection wet tissue can achieve high-level disinfection effect, effectively kills bacteria and viruses and does not produce any negative effect on an acting object.
Detailed Description
The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure.
The embodiment provides a hypochlorous acid disinfectant, which comprises the following components in parts by weight:
75 parts of EDI ultrapure water;
hypochlorous acid generator: 8 parts of hydrochloric acid and 12 parts of sodium hypochlorite;
a stabilizer: 3 parts of potassium bromide and 3 parts of sodium bromide;
a carbon dioxide generating agent: 5 parts of sodium carbonate and 1 part of sodium bicarbonate.
The preparation method of the hypochlorous acid disinfectant comprises the following steps based on the parts by weight of the components of the hypochlorous acid disinfectant:
step 1, opening a dosing tank, setting the temperature to 30 ℃, adding EDI ultrapure water, starting stirring, sequentially adding sodium carbonate and sodium bicarbonate, adding a 10% dilute hydrochloric acid solution after the components are fully dissolved, and fully stirring for 2-3 hours to saturate the generated carbon dioxide in the dosing tank and form a dynamic balance in an aqueous solution; wherein, the proportioning tank for preparing the hypochlorous acid adopts a vacuum homogeneous emulsifying tank which mainly provides the uniform stirring force required by the synthesis of the hypochlorous acid, and if the stirring is not in place, the generation failure of the hypochlorous acid can be directly caused;
and 2, opening the dosing tank, and adding potassium bromide and sodium bromide to fully dissolve the potassium bromide and the sodium bromide, so that the potassium bromide and the sodium bromide can play a role of a stabilizer in a system.
Step 3, adding sodium hypochlorite into the batching tank, and adjusting the pH value of the solution to 5.8;
step 4, generating a hypochlorous acid solution in the material preparation tank, wherein the concentration of the hypochlorous acid solution is 115 ppm;
the amount of the generated hypochlorous acid solution can be adjusted by adjusting the adding amount of the dilute hydrochloric acid solution in the whole process.
A preparation method of a disinfectant wet tissue comprises the following steps:
step 1, carrying out anti-oxidation treatment on a melt-blown cloth for manufacturing the wet tissue, namely spraying an antioxidant on the surface, wherein the antioxidant is a mixture of tea polyphenol and phytic acid, the specific addition ratio is 3:1, mixing, dissolving with absolute ethyl alcohol, the ratio of the ethyl alcohol to the antioxidant is 5:2, and then drying at 35-37 ℃;
wherein, the melt-blown fabric adopts the melt-blown fabric with the gram weight of 60g, and the melt-blown fabric is formed by drafting polymer melt trickle extruded from spinneret orifices by adopting high-speed hot air flow so as to form superfine fibers which are collected on a coagulation net curtain or a roller and are bonded to form the melt-blown non-woven fabric;
step 2, fully-closed spraying is adopted by a spraying device during spraying, the spraying can be completed in a closed chamber, and carbon dioxide is continuously introduced into the closed chamber;
and 3, filling the sterilized wet tissue into an outer package, and spraying a silver ion spraying film on the inner wall of the outer package, wherein the silver ion spraying film can form charge balance with hypochlorous acid sterilization factors in the outer package of plastic bags.
Through above link and technology processing, finally obtain a stability can reach 2 years's hypochlorous acid disinfection wet piece of cloth that contains hypochlorous acid disinfection factor, conventional wet piece of cloth preparation is direct to spray the immersion fluid on the non-woven fabrics, it is just right to pack, but hypochlorous acid itself belongs to strong oxidizing substance, can take place the reaction with fibre and viscose on the non-woven fabrics to damage the non-woven fabrics, the equilibrium of hypochlorous acid antiseptic solution itself has been destroyed, stability can not guarantee, consequently bactericidal effect also can not guarantee.
The above description is only a preferred embodiment of the present invention, and the technical solutions to achieve the objects of the present invention by basically the same means are all within the protection scope of the present invention.
Claims (9)
1. The hypochlorous acid disinfectant is characterized by comprising the following components in parts by weight:
70-80 parts of EDI ultrapure water;
15-30 parts of hypochlorous acid generating agent;
6-12 parts of a stabilizer;
4.5-9 parts of a carbon dioxide generating agent.
2. The hypochlorous acid disinfectant as claimed in claim 1, wherein: the hypochlorous acid generating agent comprises the following components in parts by weight:
5-10 parts of hydrochloric acid;
10-20 parts of sodium hypochlorite.
3. The hypochlorous acid disinfectant as claimed in claim 1, wherein: the stabilizer comprises the following components in parts by weight:
3-6 parts of potassium bromide;
3-6 parts of sodium bromide.
4. The hypochlorous acid disinfectant as claimed in claim 1, wherein: the carbon dioxide generating agent comprises the following components in parts by weight:
4-6 parts of sodium carbonate;
0.5-3 parts of sodium bicarbonate.
5. The preparation method of the hypochlorous acid disinfectant is characterized by comprising the following steps of:
step 1, opening a material preparation tank, setting the temperature to 20-40 ℃, adding EDI ultrapure water, starting stirring, sequentially adding sodium carbonate and sodium bicarbonate, adding 10% dilute hydrochloric acid solution after the components are fully dissolved, and fully stirring for 2-3 hours;
step 2, adding potassium bromide and sodium bromide into a batching tank to fully dissolve the potassium bromide and the sodium bromide;
step 3, adding sodium hypochlorite into the batching tank, and adjusting the pH value of the solution to 5.5-6.5;
and 4, generating a hypochlorous acid solution in the batching tank, wherein the concentration range of the hypochlorous acid solution is between 85ppm and 220 ppm.
6. The method for preparing hypochlorous acid disinfectant as claimed in claim 5, wherein the method comprises the following steps: the batching jar adopts vacuum homogeneity emulsification jar.
7. The preparation method of the disinfectant wet tissue is characterized by comprising the following steps:
step 1, carrying out anti-oxidation treatment on melt-blown cloth for manufacturing the wet tissue through an antioxidant, and drying at 35-37 ℃;
and 2, fully-closed spraying is adopted by the spraying device during spraying, and carbon dioxide is continuously introduced into the closed space.
8. The method for preparing a sterilized wet towel according to claim 7, wherein: also comprises the following steps:
and 3, filling the sterilized wet tissue into an outer package, and spraying a silver ion spraying film on the inner wall of the outer package.
9. The method for preparing a sterilized wet towel according to claim 7, wherein: the antioxidant is a mixture of tea polyphenol and phytic acid, and the addition ratio of the tea polyphenol to the phytic acid is 2-4: 1; mixing the antioxidants, and dissolving with anhydrous ethanol at a ratio of ethanol to antioxidant of 2-3: 1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010912456.0A CN111990410A (en) | 2020-09-03 | 2020-09-03 | Hypochlorous acid disinfectant, preparation method thereof and preparation method of disinfectant wet tissue |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010912456.0A CN111990410A (en) | 2020-09-03 | 2020-09-03 | Hypochlorous acid disinfectant, preparation method thereof and preparation method of disinfectant wet tissue |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112897194A (en) * | 2021-04-19 | 2021-06-04 | 余小龙 | Production method of degradable hypochlorous acid disinfection wet tissue |
| CN113170801A (en) * | 2021-04-26 | 2021-07-27 | 贵州扬生医用器材有限公司 | Disinfectant and preparation method and application thereof |
| CN113197218A (en) * | 2021-03-30 | 2021-08-03 | 天圣制药集团股份有限公司 | Disinfectant and preparation method thereof |
| CN113907072A (en) * | 2021-09-09 | 2022-01-11 | 潍坊红阳药业有限公司 | Preparation method of high-precision weak acid hypochlorite disinfectant |
| CN115669655A (en) * | 2021-07-29 | 2023-02-03 | 重庆市普康消毒用品有限公司 | Stabilizer for chlorine-containing disinfectant, stable 84 disinfectant and preparation method thereof |
| CN116058383A (en) * | 2023-03-29 | 2023-05-05 | 山东利尔康医疗科技股份有限公司 | High-level disinfection wet tissue and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113197218A (en) * | 2021-03-30 | 2021-08-03 | 天圣制药集团股份有限公司 | Disinfectant and preparation method thereof |
| CN112897194A (en) * | 2021-04-19 | 2021-06-04 | 余小龙 | Production method of degradable hypochlorous acid disinfection wet tissue |
| CN113170801A (en) * | 2021-04-26 | 2021-07-27 | 贵州扬生医用器材有限公司 | Disinfectant and preparation method and application thereof |
| CN115669655A (en) * | 2021-07-29 | 2023-02-03 | 重庆市普康消毒用品有限公司 | Stabilizer for chlorine-containing disinfectant, stable 84 disinfectant and preparation method thereof |
| CN113907072A (en) * | 2021-09-09 | 2022-01-11 | 潍坊红阳药业有限公司 | Preparation method of high-precision weak acid hypochlorite disinfectant |
| CN116058383A (en) * | 2023-03-29 | 2023-05-05 | 山东利尔康医疗科技股份有限公司 | High-level disinfection wet tissue and preparation method thereof |
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