CN111643417B - Antiseptic composition for cosmetics and preparation method thereof - Google Patents
Antiseptic composition for cosmetics and preparation method thereof Download PDFInfo
- Publication number
- CN111643417B CN111643417B CN202010648688.XA CN202010648688A CN111643417B CN 111643417 B CN111643417 B CN 111643417B CN 202010648688 A CN202010648688 A CN 202010648688A CN 111643417 B CN111643417 B CN 111643417B
- Authority
- CN
- China
- Prior art keywords
- extract
- parts
- cosmetics
- pistachio
- preservative composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of cosmetics, and particularly relates to an antiseptic composition for cosmetics and a preparation method thereof, wherein the antiseptic composition comprises the following components in parts by weight: 1-10 parts of pistachio extract, 1-10 parts of phellinus linteus extract, 1-8 parts of isoferulic acid, 3-20 parts of polyol and 40-60 parts of deionized water. The preservative composition provided by the invention consists of the pistachio extract, the phellinus linteus extract and isoferulic acid, has a remarkable inhibition effect on various common pollution bacteria in cosmetics, can broaden the antibacterial spectrum of a single component, is a natural component, has low skin sensitization and wide pH tolerance value (3-9), and can be applied to various skin care products, color cosmetics or cosmeceuticals.
Description
Technical Field
The invention belongs to the technical field of cosmetics. More particularly, it relates to a preservative composition for cosmetics and a preparation method thereof.
Background
The addition of preservatives to cosmetics can prevent microbial growth, protect the product, prolong the shelf life of the product, ensure the safety of the product, and prevent possible infection of the consumer due to the use of products contaminated with microorganisms. The cosmetics are polluted by microorganisms to cause deterioration, and the products polluted by the microorganisms have the changes of turbidity, precipitation, color change, pH change, foaming, taste change and the like; if the emulsion system is adopted, emulsion breaking, blocking and the like can occur.
At present, the widely used chemical preservatives mainly include parabens, formaldehyde releasers, benzyl alcohol and derivatives thereof, methylisothiazolinone or phenoxyethanol and the like. Preservatives all have the optimum pH for their action (table 1 below), however most chemical preservatives have a narrow pH tolerance, resulting in their use only in cosmetics within a specific pH range; and a few of quaternary amines with a larger pH action range, such as quaternary amine-15, karson and the like, have irritation to the skin, and particularly, the quaternary amine-15 has higher irritation to the skin. Meanwhile, the single preservative with broad antibacterial spectrum is less at present, and two or more chemical preservatives are compounded. Although these chemical preservatives have excellent antibacterial properties after being compounded, they are worried and questioned by consumers due to their potential safety. Therefore, it is important to develop a safe, mild and wide pH tolerance preservative system from natural plants.
TABLE 1 cosmetic common preservative types and characteristics
Disclosure of Invention
The invention aims to solve the technical problem of overcoming the defects and defects of narrow pH value tolerance and the like of the existing chemical preservative composition and provides a preservative composition for cosmetics and a preparation method thereof. The antiseptic composition takes plant-derived components as antibacterial active components, and has the advantages of broad-spectrum antibacterial property, high safety and wide pH value tolerance.
The invention aims to provide a preservative composition for cosmetics, which comprises the following components in parts by weight: 1-10 parts of pistachio extract, 1-10 parts of phellinus linteus extract, 1-8 parts of isoferulic acid, 3-20 parts of polyol and 40-60 parts of deionized water.
Further, the preservative composition comprises the following components in parts by weight: 3-8 parts of pistachio extract, 1-6 parts of phellinus linteus extract, 3-5 parts of isoferulic acid, 12-20 parts of polyol and 40-60 parts of deionized water.
In some preferred embodiments, the preservative composition comprises 6 parts of pistachio extract, 4 parts of phellinus linteus extract, 4 parts of isoferulic acid, 15 parts of polyol, and 50 parts of deionized water.
In some preferred embodiments, the preservative composition comprises 5 parts of pistachio extract, 3 parts of phellinus linteus extract, 2 parts of isoferulic acid, 15 parts of polyol, and 50 parts of deionized water.
In some preferred embodiments, the preservative composition comprises 8 parts of pistachio extract, 5 parts of phellinus linteus extract, 3 parts of isoferulic acid, 15 parts of polyol, and 50 parts of deionized water.
In some preferred embodiments, the preservative composition comprises 8 parts of pistachio extract, 4 parts of phellinus linteus extract, 2 parts of isoferulic acid, 15 parts of polyol, and 50 parts of deionized water.
Further, the polyol is composed of caprylyl glycol and 1, 2-pentanediol in a weight ratio of 1: 1.
Pistachio is a plant of the genus pistacia of the family Anacardiaceae, produced in southwestern and southern Europe of Syria, Iraq and Russia. The pistachio nuts contain much tannin, phthalic acid, gallic acid, catechin, anthocyanin, and the like. The clearance rate of the pistachio alcohol extract on superoxide radical reaches 25.5%; the inhibition rate on lipid peroxidation is 80.8%; has certain antibacterial property on escherichia coli, pseudomonas aeruginosa, staphylococcus aureus and candida albicans; but has poor inhibition effect on common aspergillus niger and the like in cosmetics.
Phellinus linteus is a medicinal fungus belonging to genus Phellinus of family Polyporaceae, and the fruiting body contains mainly morin A and morin B as effective components, and is rich in polysaccharide and proteoglycan. At present, researches indicate that the 0.1mg/mL phellinus linteus water extract has 100 percent of inhibition rate on the release of free histamine and 45 percent of inhibition rate on the ear swelling of mice caused by dimethylbenzene; 0.5mg/mL of the phellinus linteus alcohol extract has the inhibition rate of 45% on the activity of hyaluronidase and the inhibition rate of 40% on the activity of tyrosinase, is mostly applied to cosmetics at present as a skin moisturizing agent and an antiallergic agent, has antibacterial selectivity and the MIC value of 500 mu g/mL on staphylococcus aureus, but has no obvious inhibition effect on common candida albicans, escherichia coli, pseudomonas aeruginosa and mold in cosmetics.
Isoferulic acid is cinnamic acid derivative, can be found in rhizome of Cimicifuga foetida of Ranunculaceae, and is white needle crystal with melting point of 230-236 deg.C and CAS number of 110993-57-2. Studies prove that isoferulic acid has a promoting effect on the activity of glutathione reductase, and the glutathione reductase can convert oxidized glutathione into reducing peptide, has an anti-aging effect, is often used as an antioxidant and a whitening agent, but has no application in the aspect of antibiosis.
Further, the pistachio extract is prepared by the following steps:
s1, taking the pistachio fruits, drying, crushing, adding 80-90% ethanol solution with the amount of 6-10 times of the raw materials, extracting at 70-85 ℃ for 60-100 min, filtering, retaining filter residues, concentrating and removing the solvent to obtain ethanol extract;
s2, taking filter residues, adding ethyl acetate with the weight being 1-5 times that of the filter residues, extracting for 1-3 times, 60-120 min each time, combining, and removing the solvent to obtain ethyl acetate extract;
s3, mixing the ethanol extract obtained in the step S1 and the ethyl acetate extract obtained in the step S2 according to the weight ratio of 3: 1-2, concentrating into suspension, purifying, decoloring and concentrating to obtain an extract, thus obtaining the pistachio extract.
Experiments prove that the composite bacteriostatic effect of the extract obtained by step-by-step extraction of ethanol and ethyl acetate, the phellinus linteus extract and isoferulic acid is the best, and the composite bacteriostatic agent has a good inhibitory effect on bacillus subtilis besides the obvious inhibitory effect on common escherichia coli, candida albicans, pseudomonas aeruginosa, aspergillus niger and staphylococcus aureus in cosmetics, so that the antibacterial spectrum of a single component is widened; the pH tolerance value detection shows that the antiseptic system can exert good bacteriostatic effect in the pH range of 3-9, so that the antiseptic system can be applied to most cosmetics as an antiseptic.
Further, the extraction temperature of the step S1 is 81 ℃; and/or the extraction time is 95 min; and/or the mass fraction of the ethanol solution is 80%.
Further, the extraction time in step S2 is 80 min.
Further, in the step S3, the ethanol extract and the ethyl acetate extract were mixed at a weight ratio of 3: 2. Different weight ratios have certain influence on the bacteriostatic effect of the antiseptic composition, and when the two are mixed according to the weight ratio of 3:2, a more ideal bacteriostatic effect can be obtained.
Further, the phellinus linteus extract is prepared by the following steps:
taking phellinus linteus sporocarp, crushing the phellinus linteus sporocarp into 20-mesh fine powder, adding deionized water with the weight 6-8 times that of the fine powder, decocting for 3-6 h, centrifuging, taking supernatant, adding 90-100% ethanol solution, precipitating at 4 ℃ overnight, centrifuging, and keeping precipitate; dissolving the precipitate with deionized water, dialyzing, and lyophilizing.
It is another object of the present invention to provide a cosmetic product comprising the preservative composition.
Further, the preservative composition is present in the cosmetic in a mass fraction of 0.01 to 1.0; further, the water-soluble polymer is present in a mass fraction of 0.01 to 0.5. In some preferred embodiments, the mass fraction of the preservative composition may be including but not limited to 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%.
The invention also provides the application of the preservative composition for cosmetics in preparing cosmetics. The cosmetic includes, but is not limited to, facial mask, skin cream, skin lotion, skin essence or face wash.
The invention has the following beneficial effects:
1) the preservative composition provided by the invention consists of the pistachio extract, the phellinus linteus extract and isoferulic acid, has a remarkable inhibition effect on various common pollution bacteria in cosmetics, widens the antibacterial spectrum of a single component, is a natural plant component, has low skin sensitization and wide pH tolerance value (3-9), and can be applied to various skin care products, color cosmetics or cosmeceuticals.
2) The antiseptic composition provided by the invention has an obvious bacteriostatic effect, has antioxidant and moisturizing effects, and can provide a good antiseptic effect and improve the beautifying effect of the product when being applied to a skin care product.
Detailed Description
The present invention is further illustrated by the following specific examples, which are not intended to limit the invention in any way. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated.
Unless otherwise indicated, reagents and materials used in the following examples are commercially available.
Example 1 preparation of pistachio extract
S1, drying the pistachio fruits, crushing, adding 80% ethanol solution with the amount 8 times of the raw materials, extracting at 81 ℃ for 95min, filtering, retaining filter residues, and concentrating to remove the solvent to obtain ethanol extract;
s2, taking filter residues, adding ethyl acetate with the amount 5 times that of the filter residues for extraction for 2 times, each time for 80min, combining, and removing the solvent to obtain ethyl acetate extract;
s3, mixing the ethanol extracting solution obtained in the step S1 and the ethyl acetate extracting solution obtained in the step S2 according to the weight ratio of 3:2, concentrating the mixture into a suspension, purifying the suspension by polyamide resin, decoloring the purified suspension by using activated carbon, and concentrating the purified suspension to obtain an extract, namely the pistachio extract.
Example 2 preparation of pistachio extract
S1, drying the pistachio fruits, crushing, adding 90% ethanol solution with the amount 8 times of the raw materials, extracting at 81 ℃ for 95min, filtering, retaining filter residues, and concentrating to remove the solvent to obtain ethanol extract;
s2, taking filter residues, adding ethyl acetate with the amount 5 times that of the filter residues for extraction for 3 times, 75min each time, combining, and removing the solvent to obtain ethyl acetate extract;
s3, mixing the ethanol extracting solution obtained in the step S1 and the ethyl acetate extracting solution obtained in the step S2 according to the weight ratio of 3:1, concentrating the mixture into a suspension, purifying the suspension by polyamide resin, decoloring the purified suspension by using activated carbon, and concentrating the purified suspension to obtain an extract, namely the pistachio extract.
Example 3 preparation of pistachio extract
S1, drying the pistachio fruits, crushing, adding 85% ethanol solution with the amount 8 times of the raw materials, extracting at 81 ℃ for 100min, filtering, retaining filter residues, and concentrating to remove the solvent to obtain ethanol extract;
s2, taking filter residues, adding ethyl acetate with the amount 5 times that of the filter residues for extraction for 2 times, each time for 80min, combining, and removing the solvent to obtain ethyl acetate extract;
s3, mixing the ethanol extracting solution obtained in the step S1 and the ethyl acetate extracting solution obtained in the step S2 according to the weight ratio of 3:1.5, concentrating to obtain a suspension, purifying the suspension by polyamide resin, decoloring by using activated carbon after purification, and concentrating to obtain an extract, namely the pistachio extract.
Example 4 preparation of Phellinus linteus extract
Pulverizing Phellinus linteus fruiting body into 20 mesh fine powder, adding deionized water 6 times the weight of the fine powder, decocting for 4 hr, centrifuging, collecting supernatant, adding 90% ethanol solution, precipitating at 4 deg.C overnight, centrifuging, and keeping precipitate; dissolving the precipitate with deionized water, dialyzing, and lyophilizing.
Examples 5 to 8 and comparative examples 1 to 3 anticorrosive compositions and parts by weight thereof
Note: wherein the polyhydric alcohol consists of caprylyl glycol and 1, 2-pentanediol in a weight ratio of 1: 1; the extract of pistachio described in examples 6 and 7 was obtained from the extract of pistachio prepared in example 1, and the extract of pistachio prepared in examples 2 and 3 was obtained in examples 5 and 8, respectively.
Comparative example 4: comparative example 4 is different from example 6 in that the pistachio extract is composed of only the ethanol extract prepared in step S1.
Test example one, patch test
The examples 5 to 8 and comparative examples 1 to 3 were prepared as antiseptic compositions, 30 volunteers were selected as subjects, and the sensitization of the samples was measured (the same batch of subjects was used for the samples). Placing 0.02g of sample into a patch applicator, placing the control hole as a blank control (no any substance is placed), applying the patch applicator with the sample to the back of a subject by using a hypoallergenic adhesive tape, wherein the test area is at least 5 x 5cm, allowing the subject to sit straight when applying, applying the patch from the lower part to the upper part, and slightly pressing the adhesive tape with palm to discharge air to make the adhesive tape tightly adhere to the skin for 24 hours; and (3) judging and reading 30min and 48h after the patch applicator is removed according to the following judging standard, and counting test results, wherein the test results are shown in the following table 2.
Interpretation criteria: (one) negative reaction; (+ -suspicious reaction: only mild erythema; (+) weak positive: erythema, infiltrates, and possibly small amounts of papules; strong positive (++): erythema, infiltrates, papules, blisters; (+++) very positive: erythema, infiltrates, papules, blisters, bulla.
TABLE 2 Patch test results
| Group of | Negative/rate | Weak positive/rate | Strong positive/rate | Very strong positive/rate | Positive rate |
| Example 5 | 30/100％ | 0/0 | 0/0 | 0/0 | 0 |
| Example 6 | 30/100％ | 0/0 | 0/0 | 0/0 | 0 |
| Example 7 | 30/100％ | 0/0 | 0/0 | 0/0 | 0 |
| Example 8 | 30/100％ | 0/0 | 0/0 | 0/0 | 0 |
| Comparative example 1 | 26/86.7％ | 2/6.7％ | 2/6.7％ | 0/0 | 13.3％ |
| Comparative example 2 | 29/96.7％ | 1/3.3％ | 0/0 | 0/0 | 3.3％ |
| Comparative example 3 | 24/80.0％ | 2/6.7％ | 3/10.0％ | 1/3.3％ | 20.0％ |
As can be seen from the above table, the antiseptic compositions described in examples 5 to 8 of the present invention have low skin sensitization, wherein the antiseptic compositions described in examples 5 to 7 have the highest safety, and no positive reaction is detected in 30 subjects; from the results of comparative example 1 and comparative example 3, it is clear that the pistachio extract and isoferulic acid have high irritation to the skin, particularly isoferulic acid, and 6 (20.0%) of 30 subjects detected positive reaction, while the phellinus linteus extract has a certain anti-allergy effect and low irritation to the skin.
Test example two, MIC value test
The antiseptic compositions of examples 5-8 and comparative examples 1-4 are used as samples, and the minimum inhibitory concentration MIC value of each sample is tested by a broth dilution method, wherein the test method comprises the following steps: diluting the above samples by two-fold dilution method with sterilized nutrient broth and Sabouraud's medium as dilution system to obtain dilution solutions with serial concentrations, inoculating Escherichia coli 1 × 108cfu/mL, Staphylococcus aureus 1X 108cfu/mL, Candida albicans 1X 106cfu/mL, Pseudomonas aeruginosa 1X 107cfu/mL Aspergillus niger 1X 105cfu/mL and Bacillus subtilis 1X 106cfu/mL, bacteria at 35 degrees C cultured for 36h, fungi at 28 degrees C cultured for 48h after observation. The test results are shown in table 3 below.
TABLE 3 MIC values for the samples
As can be seen from table 3 above, the pistachio extract has excellent inhibitory effects on escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa, and has a general inhibitory effect on aspergillus niger and bacillus subtilis; the phellinus linteus extract shows antibacterial selectivity, has certain inhibitory effect on staphylococcus aureus, has an MIC value of 500 mu g/mL, has certain inhibitory effect on other two bacteria, but has slightly poor inhibitory effect on fungi (candida albicans and aspergillus niger); isoferulic acid has no obvious inhibition effect on bacteria and fungi; surprisingly, the examples 5 to 8 formed by compounding the pistachio extract, the phellinus linteus extract and the isoferulic acid all have excellent inhibitory effects on common bacteria and fungi in cosmetics, and a certain synergistic effect of the three extracts on bacteriostasis is shown.
Test example III Effect of different pH on antimicrobial Activity of preservative compositions
The pH values of the anticorrosive compositions of example 6 and comparative example 1 are adjusted to 2, 3, 4, 5, 6, 7, 8, 9 and 10, and the diameter measurement test of the inhibition zone is carried out, and the test results are shown in the following tables 4 to 6.
TABLE 4 comparison of the average zone of inhibition of Escherichia coli by different pH antiseptic compositions
TABLE 5 comparison of the average zone of inhibition of Candida albicans by different pH antiseptic compositions
TABLE 6 comparison of the average zone of inhibition of Pseudomonas aeruginosa by different pH antiseptic compositions
As can be seen from tables 4-6 above, the pistachio extract has good inhibitory effect on Escherichia coli, Candida albicans and Pseudomonas aeruginosa within the range of 6-8; the preservative composition of example 6, which is compounded with the phellinus linteus extract and isoferulic acid, has excellent antibacterial effects on escherichia coli, candida albicans and pseudomonas aeruginosa within a range of 3-9, and compared with a single component, the compounded preservative composition can still maintain higher antibacterial activity at different pH values, and can be applied to different types of cosmetics.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (8)
1. The preservative composition for the cosmetics is characterized by comprising the following components in parts by weight: 1-10 parts of pistachio extract, 1-10 parts of phellinus linteus extract, 1-8 parts of isoferulic acid, 3-20 parts of polyol and 40-60 parts of deionized water;
the pistachio extract is prepared by the following steps:
s1, taking the pistachio fruits, drying, crushing, adding 80-90% ethanol solution with the amount of 6-10 times of the raw materials, extracting at 70-85 ℃ for 60-100 min, filtering, retaining filter residues, concentrating and removing the solvent to obtain ethanol extract;
s2, taking filter residues, adding ethyl acetate with the weight being 1-5 times that of the filter residues, extracting for 1-3 times, 60-120 min each time, combining, and removing the solvent to obtain ethyl acetate extract;
s3, mixing the ethanol extract obtained in the step S1 and the ethyl acetate extract obtained in the step S2 according to the weight ratio of 3: 1-2, concentrating into suspension, purifying, decoloring and concentrating to obtain an extract to obtain the pistachio extract;
the phellinus linteus extract is prepared by the following steps:
taking phellinus linteus sporocarp, crushing the phellinus linteus sporocarp into 20-mesh fine powder, adding deionized water with the weight 6-8 times that of the fine powder, decocting for 3-6 h, centrifuging, taking supernatant, adding 90-100% ethanol solution, precipitating at 4 ℃ overnight, centrifuging, and keeping precipitate; dissolving the precipitate with deionized water, dialyzing, and lyophilizing.
2. Preservative composition for cosmetics according to claim 1, characterized by comprising the following components in parts by weight: 3-8 parts of pistachio extract, 1-6 parts of phellinus linteus extract, 3-5 parts of isoferulic acid, 12-20 parts of polyol and 40-60 parts of deionized water.
3. Preservative composition for cosmetics according to claim 1, characterized in that the polyol consists of caprylyl glycol and 1, 2-pentanediol in a 1:1 weight ratio.
4. The preservative composition for cosmetics according to claim 1, wherein the extraction temperature of step S1 is 81 ℃; the extraction time is 95 min; the mass fraction of the ethanol solution is 80 percent; the extraction time in step S2 is 80 min.
5. The preservative composition for cosmetics according to claim 1, wherein the ethanol extract and the ethyl acetate extract are mixed in a weight ratio of 3:2 in the step S3.
6. A cosmetic comprising the preservative composition according to any one of claims 1 to 5.
7. The cosmetic according to claim 6, wherein the preservative composition is present in the cosmetic in a mass fraction of 0.01 to 1.0.
8. Use of the preservative composition for cosmetics according to any one of claims 1 to 5 for the preparation of cosmetics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010648688.XA CN111643417B (en) | 2020-07-07 | 2020-07-07 | Antiseptic composition for cosmetics and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010648688.XA CN111643417B (en) | 2020-07-07 | 2020-07-07 | Antiseptic composition for cosmetics and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111643417A CN111643417A (en) | 2020-09-11 |
| CN111643417B true CN111643417B (en) | 2021-06-25 |
Family
ID=72342391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010648688.XA Active CN111643417B (en) | 2020-07-07 | 2020-07-07 | Antiseptic composition for cosmetics and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111643417B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001226249A (en) * | 2000-02-17 | 2001-08-21 | Ichimaru Pharcos Co Ltd | Cosmetic composition including aqueous distillate from plant steam distillation |
| KR20040084580A (en) * | 2003-03-28 | 2004-10-06 | 전민현 | Cosmetic composition containing the extract of phellinus linteus mycelium which prevents skin wrinkles by moisturizing skin and provides antioxidation effect for anti-aging |
| CN105496847A (en) * | 2015-12-09 | 2016-04-20 | 名臣健康用品股份有限公司 | Cosmetic composition containing pistachio and hedera helix extracts |
| CN106963679A (en) * | 2017-03-28 | 2017-07-21 | 佛山汇沐化学科技有限公司 | One kind calm the nerves itching-relieving shower breast |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100500161B1 (en) * | 2004-12-22 | 2005-07-11 | 충청북도 | The manufacturing method and vinegar mushroom |
| CN109662926A (en) * | 2019-01-29 | 2019-04-23 | 广州锦同生物科技有限公司 | A kind of polywater moisturizing essence dew and preparation method thereof |
-
2020
- 2020-07-07 CN CN202010648688.XA patent/CN111643417B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001226249A (en) * | 2000-02-17 | 2001-08-21 | Ichimaru Pharcos Co Ltd | Cosmetic composition including aqueous distillate from plant steam distillation |
| KR20040084580A (en) * | 2003-03-28 | 2004-10-06 | 전민현 | Cosmetic composition containing the extract of phellinus linteus mycelium which prevents skin wrinkles by moisturizing skin and provides antioxidation effect for anti-aging |
| CN105496847A (en) * | 2015-12-09 | 2016-04-20 | 名臣健康用品股份有限公司 | Cosmetic composition containing pistachio and hedera helix extracts |
| CN106963679A (en) * | 2017-03-28 | 2017-07-21 | 佛山汇沐化学科技有限公司 | One kind calm the nerves itching-relieving shower breast |
Non-Patent Citations (1)
| Title |
|---|
| 裂蹄木层孔菌发酵产物抑菌活性的研究;邹莉等;《中国农学通报》;20131231;第29卷(第21期);第78-82页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111643417A (en) | 2020-09-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111632011B (en) | Moisturizing and skin-refreshing mask and preparation method thereof | |
| EP1722805B1 (en) | Bioactive compositions from theacea plants and processes for their production and use | |
| EP3281527B1 (en) | Antimicrobial traditional chinese medicine composition, and preparation method and use thereof | |
| CN110090190B (en) | Soothing cooling liquid for baby plants and preparation method thereof | |
| KR100961879B1 (en) | Alcoholic disinfectant containing green tea extract | |
| CN111228169A (en) | Magnolia officinalis plant anticorrosion and antibacterial composition and preparation process and application thereof | |
| CN107496245B (en) | Anti-aging liposome composition and preparation method and application thereof | |
| KR20150049027A (en) | Composition of preservatives and cosmetic composition comprising the same | |
| JP2003012489A (en) | Hyaluronidase activity inhibitor and moisture-retaining cosmetic | |
| CN108113925B (en) | Natural preservative, preparation method thereof and application thereof in cosmetics | |
| KR101511747B1 (en) | Natural Preservative Composition Containing the Extract of Lisimachiae Herba, Galla Rhois, Cassia Bark and Caryophylli Flos | |
| JP2008212136A (en) | Post-fermented tea and method for producing the same | |
| CN111643417B (en) | Antiseptic composition for cosmetics and preparation method thereof | |
| CN112516031B (en) | Plant extraction multi-effect composition and preparation method thereof | |
| CN111643416B (en) | Whitening and spot-fading mask and preparation method thereof | |
| CN112587458A (en) | Preservative composition and preparation method and application thereof | |
| EP2878342A1 (en) | Method for extraction of peat active substances and use of their combination in skin regenerating cosmetic formulations | |
| KR100981407B1 (en) | The cosmetic composition containing the natural antibiotic-complex consisted of the nelumbo nucifera leaf extracts, Kochia scoparia extracts and Lycium chinense extracts | |
| CN111297765B (en) | Roxburgh rose extract and antibacterial application thereof | |
| Dzomba | Formulation and evaluation of a herbal shampoo using flavonoid glycosides from Dicerocaryum senecioides | |
| CN108938486B (en) | Anticorrosive composite and its preparation method and application | |
| CN114469817A (en) | Pore-refining composition and preparation method and application thereof | |
| CN109276519B (en) | Paris polyphylla fermentation stock solution and preparation method and application thereof | |
| KR20220117942A (en) | Novel Punica granatum Extracts-Zinc oxide Nanoparticles and its use | |
| CN111067843A (en) | Composition with anticorrosion function and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20210603 Address after: 528137 Building 1, No.33, Sanjiang Road, Leping Town, Sanshui District, Foshan City, Guangdong Province Applicant after: Guangdong shengxueyan Biotechnology Co.,Ltd. Address before: 510665 4061, 4th floor, No.3, Hengling 2nd Road, Tangdong, Tianhe District, Guangzhou City, Guangdong Province Applicant before: Guangzhou Weichuang Technology Development Co.,Ltd. |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |