CN111528921B - Information acquisition device - Google Patents
Information acquisition device Download PDFInfo
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- CN111528921B CN111528921B CN202010460838.4A CN202010460838A CN111528921B CN 111528921 B CN111528921 B CN 111528921B CN 202010460838 A CN202010460838 A CN 202010460838A CN 111528921 B CN111528921 B CN 111528921B
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- optical fiber
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- ultrasonic probe
- blood vessel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0891—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4416—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to combined acquisition of different diagnostic modalities, e.g. combination of ultrasound and X-ray acquisitions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
- A61B8/4455—Features of the external shape of the probe, e.g. ergonomic aspects
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
- A61B8/4488—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer the transducer being a phased array
Abstract
The invention relates to the technical field of information acquisition, in particular to an information acquisition device. In the information acquisition device provided by the invention, laser emitted by a laser source is transmitted to a self-focusing coupling optical fiber through a first discrete end optical fiber, a self-focusing laser beam output by the self-focusing coupling optical fiber is focused on the surface of a sample to be detected through a transparent ultrasonic probe to generate a photoacoustic signal, and the transparent ultrasonic probe receives the photoacoustic signal; the piezoelectric element containing rare earth is excited by laser to generate fluorescence, the fluorescence irradiates a sample to be detected to generate an optical signal, and the optical signal is transmitted to the miniature CCD image sensor through the self-focusing coupling optical fiber and the second discrete end optical fiber by the transparent ultrasonic probe; the transparent probe may also transmit and receive ultrasonic signals by itself. The device can gather the photosignal, the optoacoustic signal and the ultrasonic signal of the sample that awaits measuring, can survey the inside condition of the sample that awaits measuring after three kinds of signal analysis processing formation of image, and three kinds of signal formation of image results are compared each other, and the superiority is lacked complementarily, can improve the degree of accuracy that detects greatly.
Description
Technical Field
The invention relates to the technical field of information acquisition, in particular to an information acquisition device.
Background
With the rapid development of economic level, the living standard of people is rapidly improved, the threat of vascular diseases is increasingly prominent, and the incidence of diseases is increased year by year. The traditional blood vessel detection methods include magnetic resonance angiography, CT angiography and the like, although the methods can well display the external form and the internal contour of a blood vessel, the methods cannot display the detailed structures of the blood vessel wall and the blood vessel cavity, intravascular ultrasonic imaging utilizes a miniature ultrasonic transducer to detect the size of the blood vessel cavity and the structure of the blood vessel wall through intravascular imaging, the anatomical structure of the cross section of the blood vessel can be displayed in real time, and the methods play an irreplaceable role in detection of various blood vessel diseases.
With current techniques, the images obtained using ultrasound imaging may have artifacts that do not completely accurately reflect the structure of the blood vessel, with a simple acquisition of the ultrasound signals.
Disclosure of Invention
The invention provides an information acquisition device which can acquire various signals in blood vessels, can greatly improve the detection accuracy by imaging in various signal modes, and avoids the problems that an image obtained by simply acquiring ultrasonic signals for blood vessel detection possibly has artifacts and the internal structure of the blood vessel cannot be completely and accurately reflected.
The specific technical scheme is as follows:
the invention provides an information acquisition device, comprising: the device comprises a transparent ultrasonic probe, a laser source, a miniature CCD image sensor, a first discrete end optical fiber, a second discrete end optical fiber and a self-focusing coupling optical fiber;
the first end of the first discrete end optical fiber is connected with the laser source, the second end of the first discrete end optical fiber is connected with the first end of the self-focusing coupling optical fiber through the optical fiber coupler, and the second end of the self-focusing coupling optical fiber is connected with the transparent ultrasonic probe;
the first end of the second discrete-end optical fiber is connected with the miniature CCD image sensor, and the second end of the second discrete-end optical fiber is connected with the first end of the self-focusing coupling optical fiber through an optical fiber coupler;
the laser source is used for emitting laser, and the laser irradiates a sample to be measured through the first discrete end optical fiber and the self-focusing coupling optical fiber and the transparent ultrasonic probe to generate a photoacoustic signal;
a piezoelectric element containing rare earth is arranged in the transparent ultrasonic probe and is used for being excited by the laser to generate fluorescence, and the fluorescence irradiates the sample to be detected to generate an optical signal;
the transparent ultrasonic probe is used for transmitting an ultrasonic signal and receiving an echo of the ultrasonic signal and the photoacoustic signal.
Preferably, the piezoelectric element is a rare earth-containing piezoelectric material.
Preferably, the rare earth element in the rare earth-containing piezoelectric element is selected from Eu, Er, Pr, Sm, La, Tb, Gd, or Lu.
Preferably, the piezoelectric material in the rare earth-containing piezoelectric element is selected from piezoelectric single crystal, piezoelectric ceramic or a composite material formed by piezoelectric ceramic and polymer.
Preferably, the sample to be tested is in a cavity shape.
Preferably, the sample to be tested comprises a blood vessel or a duct.
Preferably, the method further comprises the following steps: a first imaging module and a second imaging module;
the first imaging module is connected with the miniature CCD image sensor, and the second imaging module is connected with the transparent ultrasonic probe.
Preferably, the unit arrangement mode of the piezoelectric element containing rare earth is single array unit arrangement, linear array arrangement or area array arrangement.
Preferably, the shape of the transparent ultrasound probe is concave or convex.
Preferably, the laser source is a pulsed laser.
According to the technical scheme, the invention has the following advantages:
the invention provides an information acquisition device, wherein laser emitted by a laser source in the device is transmitted to a self-focusing coupling optical fiber through a first discrete end optical fiber, a self-focusing laser beam output by the self-focusing coupling optical fiber is focused on the surface of a sample to be detected through a transparent ultrasonic probe, and a generated photoacoustic signal is received by the transparent ultrasonic probe. The piezoelectric element is excited by laser to generate fluorescence, the fluorescence irradiates a sample to be detected to generate an optical signal, and the optical signal is output to the miniature CCD image sensor through the self-focusing coupling optical fiber and the second discrete end optical fiber and converted into an electric signal. The transparent probe may also transmit and receive ultrasonic signals by itself. The device can gather the photosignal, the optoacoustic signal and the ultrasonic signal of the sample that awaits measuring, can survey the inside condition of the sample that awaits measuring after follow-up three kinds of signal analysis processing formation of image, and three kinds of signal formation of image results are compared each other, and the superiority is lacked complementarily, can improve the accuracy that the sample that awaits measuring detected greatly.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive exercise.
Fig. 1 is a schematic structural diagram of an information acquisition device according to an embodiment of the present invention;
wherein the illustration is as follows:
1. a transparent ultrasonic probe; 2. a first discrete end optical fiber; 3. a self-focusing coupling fiber; 4. a micro CCD image sensor; 5. a laser source; 6. a sample to be tested; 7. a fiber coupler; 8. a second discrete end optical fiber.
Detailed Description
The embodiment of the invention provides an information acquisition device, which is used for solving the problems that an image obtained by simply acquiring an ultrasonic signal for blood vessel detection and utilizing ultrasonic imaging at present may have artifacts and cannot completely and accurately reflect the internal structure of a blood vessel.
In order to make the objects, features and advantages of the present invention more obvious and understandable, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it should be apparent that the embodiments described below are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
One embodiment of an information collecting apparatus provided by the present invention includes: the device comprises a transparent ultrasonic probe 1, a laser source 5, a miniature CCD image sensor 4, a first discrete end optical fiber 2, a second discrete end optical fiber 8 and a self-focusing coupling optical fiber 3;
the first end of the first discrete end optical fiber 2 is connected with the laser source 5, the second end of the first discrete end optical fiber 2 is connected with the first end of the self-focusing coupling optical fiber 3 through the optical fiber coupler 7, and the second end of the self-focusing coupling optical fiber 3 is connected with the transparent ultrasonic probe 1;
the first end of the second discrete end optical fiber 8 is connected with the miniature CCD image sensor 4, and the second end is connected with the first end of the self-focusing coupling optical fiber 3 through the optical fiber coupler 7;
the laser source 5 is used for emitting excitation, and laser irradiates a sample 6 to be measured through the first discrete end optical fiber 2 and the self-focusing coupling optical fiber 3 and the transparent ultrasonic probe 1 to generate a photoacoustic signal; a piezoelectric element containing rare earth is arranged in the transparent ultrasonic probe 1, the piezoelectric element containing rare earth is used for generating fluorescence after being excited by laser, and the fluorescence irradiates on a sample 6 to be detected to generate an optical signal;
the transparent ultrasonic probe 1 is used for transmitting ultrasonic signals and receiving echoes and photoacoustic signals of the ultrasonic signals;
in the embodiment of the invention, laser emitted by a laser source 5 is transmitted to a self-focusing coupling optical fiber 3 through a first discrete end optical fiber 2, a self-focusing laser beam output by the self-focusing coupling optical fiber 3 is focused on the surface of a sample 6 to be detected through a transparent ultrasonic probe 1, and a generated photoacoustic signal is received by the transparent ultrasonic probe 1 and then transmitted to the outside for analysis and processing to perform imaging.
The piezoelectric element containing rare earth in the transparent ultrasonic probe 1 can generate fluorescence after being excited by laser, the fluorescence irradiates a sample 6 to be detected, and an optical signal reflected on the sample 6 to be detected is output to the miniature CCD image sensor 4 through the self-focusing coupling optical fiber 3 and the second discrete end optical fiber 9 and is converted into an electric signal.
The transparent probe can also transmit and receive ultrasonic signals by itself and then transmit the ultrasonic signals to the outside for analysis and processing for imaging.
The information acquisition device provided by the embodiment of the invention can acquire the optical signal, the photoacoustic signal and the ultrasonic signal of the sample 6 to be detected, and can observe the internal condition of the sample 6 to be detected after analyzing, processing and imaging the three signals, thereby greatly improving the detection accuracy of the sample 6 to be detected.
In the embodiment of the invention, the rare earth element in the rare earth-containing piezoelectric element is selected from Eu, Er, Pr, Sm, La, Tb, Gd or Lu. The piezoelectric material in the rare earth-containing piezoelectric element is selected from piezoelectric single crystal, piezoelectric ceramic or a composite material formed by piezoelectric ceramic and polymer.
In another embodiment of the information collecting device of the present invention, the sample 6 is in a cavity shape.
In another embodiment of the information collecting apparatus provided by the present invention, the sample 6 to be measured includes a blood vessel or a conduit, and in this embodiment, a blood vessel is preferred.
In another embodiment of the information acquisition apparatus, the unit arrangement mode of the piezoelectric element containing rare earth is single array element arrangement, linear array arrangement or area array arrangement.
In another embodiment of the information collecting apparatus provided by the present invention, the information collecting apparatus further includes: a first imaging module and a second imaging module;
the first imaging module is connected with the miniature CCD image sensor 4, and the second imaging module is connected with the transparent ultrasonic probe 1.
In the embodiment of the invention, the first imaging module can realize fluorescence imaging, specifically, optical signals are converted into electric signals through the CCD image sensor 4, the electric signals are amplified and then converted into digital signals, and the digital signals form images after data processing to finish fluorescence imaging. The second imaging module can realize photoacoustic imaging and ultrasonic imaging, specifically, ultrasonic signals and photoacoustic signals are converted into electric signals, the electric signals are amplified and then converted into digital signals, and the digital signals form images after data processing, so that the ultrasonic imaging and the photoacoustic imaging are completed. The imaging principle of the first imaging module and the second imaging module is the prior art, and the embodiment of the invention is not described in detail.
The information acquisition device provided by the embodiment of the invention realizes the imaging effects of high accuracy, good resolution and high recovery by utilizing the high contrast of photoacoustic imaging and the high penetration depth of ultrasonic imaging, combines the photoacoustic imaging result and the ultrasonic imaging result together for analysis and comparison, and greatly improves the detection accuracy. The device integrates photoacoustic imaging, ultrasonic imaging and fluorescence imaging, compares with each other, has good imaging effect and good contrast, and greatly improves the detection precision in the blood vessel.
In another embodiment of the information acquisition apparatus provided by the present invention, the shape of the transparent ultrasonic probe 1 is concave or convex. The transparent ultrasonic probe 1 may have any shape, and the shape of the transparent ultrasonic probe 1 is not particularly limited in the embodiment of the present invention.
In another embodiment of the information collecting apparatus provided by the present invention, the laser source 5 is a pulsed laser.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (7)
1. A blood vessel information collecting device characterized by comprising: the device comprises a transparent ultrasonic probe, a laser source, a miniature CCD image sensor, a first discrete end optical fiber, a second discrete end optical fiber and a self-focusing coupling optical fiber;
the first end of the first discrete end optical fiber is connected with the laser source, the second end of the first discrete end optical fiber is connected with the first end of the self-focusing coupling optical fiber through the optical fiber coupler, and the second end of the self-focusing coupling optical fiber is connected with the transparent ultrasonic probe;
the first end of the second discrete-end optical fiber is connected with the miniature CCD image sensor, and the second end of the second discrete-end optical fiber is connected with the first end of the self-focusing coupling optical fiber through an optical fiber coupler;
the laser source is used for emitting laser, and the laser irradiates a blood vessel through the first discrete end optical fiber and the self-focusing coupling optical fiber and through the transparent ultrasonic probe to generate a photoacoustic signal;
a piezoelectric element containing rare earth is arranged in the transparent ultrasonic probe and is used for being excited by the laser to generate fluorescence, and the fluorescence irradiates the blood vessel to generate an optical signal;
the transparent ultrasonic probe is used for transmitting an ultrasonic signal and receiving an echo of the ultrasonic signal and the photoacoustic signal.
2. The blood vessel information collecting device according to claim 1, wherein the rare earth element in the rare earth-containing piezoelectric element is selected from Eu, Er, Pr, Sm, La, Tb, Gd, or Lu.
3. The blood vessel information acquisition device according to claim 2, wherein the piezoelectric material in the rare earth-containing piezoelectric element is selected from piezoelectric single crystal, piezoelectric ceramic or a composite material formed by piezoelectric ceramic and polymer.
4. The blood vessel information collecting device according to claim 1, further comprising: a first imaging module and a second imaging module;
the first imaging module is connected with the miniature CCD image sensor, and the second imaging module is connected with the transparent ultrasonic probe.
5. The blood vessel information collecting device according to claim 1, wherein the unit arrangement of the rare earth-containing piezoelectric elements is a single-element arrangement, a linear array arrangement, or an area array arrangement.
6. The apparatus according to claim 1, wherein the shape of the transparent ultrasound probe is concave or convex.
7. The blood vessel information collecting device according to claim 1, wherein the laser source is a pulsed laser.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010460838.4A CN111528921B (en) | 2020-05-27 | 2020-05-27 | Information acquisition device |
| PCT/CN2020/101779 WO2021237895A1 (en) | 2020-05-27 | 2020-07-14 | Information acquisition device |
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| CN202010460838.4A CN111528921B (en) | 2020-05-27 | 2020-05-27 | Information acquisition device |
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| CN111528921A CN111528921A (en) | 2020-08-14 |
| CN111528921B true CN111528921B (en) | 2021-01-29 |
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| CN113838001B (en) * | 2021-08-24 | 2024-02-13 | 内蒙古电力科学研究院 | Ultrasonic wave full focusing image defect processing method and device based on nuclear density estimation |
| CN114886389A (en) * | 2022-07-14 | 2022-08-12 | 之江实验室 | Three-dimensional photoacoustic/ultrasonic dual-mode endoscope and imaging method |
| CN117898766A (en) * | 2024-03-20 | 2024-04-19 | 柔脉医疗(深圳)有限公司 | Vascular imaging method, vascular imaging device, electronic equipment and storage medium |
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| CN104288793A (en) * | 2014-10-31 | 2015-01-21 | 苏州大学 | Nanometer ultrasonic/fluorescent bimodal contrast agent as well as preparation method and application thereof |
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| WO2010028817A2 (en) * | 2008-09-10 | 2010-03-18 | Medizinische Universität Graz | Medical system |
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| CN104288793A (en) * | 2014-10-31 | 2015-01-21 | 苏州大学 | Nanometer ultrasonic/fluorescent bimodal contrast agent as well as preparation method and application thereof |
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Effective date of registration: 20220511 Address after: 528000 room a312-7, block a, Nanhai industrial think tank City Phase I, Taoyuan Road, software park, Shishan town, Nanhai District, Foshan City, Guangdong Province Patentee after: Guangdong Yunsheng Technology Co.,Ltd. Address before: No.729, Dongfeng East Road, Yuexiu District, Guangzhou City, Guangdong Province 510060 Patentee before: GUANGDONG University OF TECHNOLOGY |