CN110426373A - A kind of method of Brillouin scattering and optical coherence elastogram in situ detection - Google Patents
A kind of method of Brillouin scattering and optical coherence elastogram in situ detection Download PDFInfo
- Publication number
- CN110426373A CN110426373A CN201910638803.2A CN201910638803A CN110426373A CN 110426373 A CN110426373 A CN 110426373A CN 201910638803 A CN201910638803 A CN 201910638803A CN 110426373 A CN110426373 A CN 110426373A
- Authority
- CN
- China
- Prior art keywords
- sample
- optical
- elastogram
- brillouin scattering
- light
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
Abstract
The present invention provides the method for a kind of Brillouin scattering and optical coherence elastogram in situ detection, using the method for wavelength-division multiplex and confocal optical path by Brillouin scattering elastogram system and the optical coherence elastogram system integration, then the carry out image checking that two kinds of detection systems are independent of each other may be implemented by the sequential control system of computer, so as to complete the in situ detection of two kinds of elasticity modulus of sample bulk modulus and the coefficient of rigidity in the case where not mobile example position.The invention has the advantages that the comparative study of two kinds of elasticity modulus technical support can be provided for the clinically diagnosis of numerous diseases and early prevention.This is for clinically a variety of diseases, diagnosis, treatment and the prevention of especially multiple ophthalmology disease have great significance and be worth at present.
Description
Technical field
The present invention relates to a kind of imaging detection method of biological tissue elasticity modulus, specially a kind of achievable Brillouin dissipates
Penetrate the method with optical coherence elastogram in situ detection.
Background technique
Brillouin scattering elastogram and optical coherence elastogram are the newest of biological tissue elasticity nature examination at present
Means, the physical principle of the two is different, can obtain the bulk modulus and the coefficient of rigidity of biological tissue respectively, this for
The diagnoses and treatment of some clinical diseases, especially ophthalmology disease (myopia, keratoconus etc.) are of great significance.But now with
There are still some technical restrictions for the research of pass Brillouin scattering elastogram and optical coherence elastogram.
The myopia of present clinically some chronic diseases especially ophthalmology, presbyopia disease as cataract in other words, very
It can not directly judge whether to fall ill in early period when more, can be detected from the angle of biomethanics using the mode of elastomeric check
Whether the property of tissue has occurred pathologic change, so need the means of elastomeric check to obtain the resilient nature of tissue,
But other technological means can not accomplish the so high precision of optical instrument, and the use of optical instrument be a kind of lossless hand
Section.Why to do comparison is because the present coefficient of rigidity and bulk modulus are it is considered that sample characterization resilient nature
Classical physics amount, but since the magnitude of two kinds of elasticity modulus is usually poor very much, is not available same system and makes ratio
Compared with, thus the advantages of our patent may be implemented this problem, do so be exactly can be respectively from analysis group in two kinds of modulus
How the elasticity knitted changes on earth, and can determining two kinds of elasticity modulus in other words, which kind of is particularly suited for clinically biological group
The detection for knitting resilient nature differs greatly, and there is no a kind of technological means that can be realized simultaneously the detection of two kinds of elasticity modulus at present,
It is even more impossible to carry out the comparative study of two kinds of elasticity modulus.
Summary of the invention
The purpose of the present invention is to provide a kind of achievable Brillouin scattering and optical coherence elastogram in situ detections
Method.Since the pathogenesis of current many clinical diseases is related to the change of its bio-mechanical property, there are many elasticity
The detection method of modulus is in conceptual phase, and wherein Brillouin scattering elastography can detecte the body bullet of biological tissue
Property modulus, optical coherence elastography can detecte the coefficient of rigidity of biological tissue, these two methods are at present
The most possible technological means for realizing the detection of biological tissue elasticity modulus.But since two kinds of technological means detect bulk modulus
It is different with the physical mechanism of the coefficient of rigidity, therefore there is no a kind of technological means that being total to for two kinds of elasticity modulus may be implemented at present
With detection and comparative study, main cause is because Brillouin scattering elastogram and optical coherence elastogram measure respectively
Bulk modulus and the coefficient of rigidity have different elasticity modulus magnitudes, and body modulus is in Gpa magnitude and modulus of shearing in kpa
Magnitude.
The present invention is using the confocal integrated unlike signal channel for being implemented in combination with two kinds of optical systems of wavelength-division multiplex and optical path
It is integrated, the integrated of Brillouin scattering elastogram system and optical coherence elastogram system may be implemented, and then realize detection
The in situ detection and comparative study of bulk modulus and the coefficient of rigidity.Then two kinds are realized by computer sequential control algorithm
The asynchronous detection in the original position of optical system.
A kind of method of achievable Brillouin scattering and optical coherence elastogram in situ detection, the system that the present invention uses
Forming includes wideband light source SLD1, optoisolator 2, photo-coupler 3, collimating mirror 1, optical attenuator 5, condenser lens 1, instead
Penetrate mirror 7, wavelength division multiplexer 8, optical collimator 9, scanning galvanometer 10, focusing objective len 11, annular ultrasonic transducer 12, collimating mirror two
13, condenser lens 2 14, diffraction grating 15, condenser lens 3 16, COMES camera 17, computer 18, narrow linewidth laser 19,
Optical circulator 20, collimating mirror 3 21, cylindrical mirror 1, virtual phase control battle array spectrometer VIPA 1, cylindrical mirror 2 24, rectangular aperture
One 25, condenser lens 4 26, virtual phase control battle array spectrometer VIPA 2 27, condenser lens 5 28, rectangular aperture 2 29, condenser lens
6 30, condenser lens 7 31, the method for EMCCD32.
Detailed process is as follows for the method for foregoing invention:
(1) subsystem one: acoustic radiation force optical coherence elastogram
The system core principle is that the ultrasonic action generated using ultrasonic transducer inspires shearing in biological tissue surface
Then wave obtains the speed that shearing wave is propagated in sample surfaces using optical coherence elastography, and then by shearing wave wave
Corresponding relationship between speed and tissue modulus of shearing calculates the modulus of shearing and Young's modulus of sample, can be by following formula meter
It obtains:
E is modulus of shearing in formula, and ρ is sample rate, VSFor shear-wave velocity.Detailed process is as follows for system:
1. wideband light source SLD (1) launches the broadband near infrared light that central wavelength is 850nm, it is by central wavelength
The optoisolator of 850nm, central wavelength are the photo-coupler of 850nm, are divided into the two-beam that phase power ratio is 90:10, wherein function
Collimating mirror one of the reference beam through central wavelength 850nm that rate is 10%, optical attenuator, condenser lens one are incident on reflecting mirror,
Reference beam is after reflecting mirror reflects by backtracking at coupler；
2. the sample light that another beam power is 90% passes through wavelength division multiplexer, optical collimator, scanning vibration from coupler outgoing
Mirror, focusing objective len, annular ultrasonic transducer are incident at sample, scanning galvanometer by computer driver control to sample into
Row 3-D scanning, annular ultrasonic transducer is controlled the ultrasonic exciting for generating MHz by computer drivers, in sample surfaces
Elastic wave is generated, after then sample light and sample tissue are had an effect, back-scattering light, which is focused after object lens focus, prolongs original
Road is interfered back to photo-coupler and reference light；Sample light and with reference to the interference light signal after the interference of light from optical coupling
Another channel of device is emitted, and collimated mirror two, condenser lens two focuses on diffraction grating, and interference light is divided through diffraction grating, by
Condenser lens three focuses on COMES camera, and COMES camera is acquired interference signal by computer drivers control
Processing, can complete the detection function of optical coherence elastogram system at this time；
(2) subsystem two: Brillouin scattering elastogram
The system core principle is to inspire Brillouin scattering in sample using laser, acoustooptical effect is generated, by scanning
F-P interferometer and photon receiver obtain the Brillouin shift of sample, and then obtain the velocity of sound, and the body of sample is calculated by the velocity of sound
Elasticity modulus.It can be calculated by following formula:
K is modulus of shearing in formula, and ρ is sample rate, VcFor phonon speed.
Detailed process is as follows for system:
3. the continuous laser that wavelength is 532nm is then issued by narrow linewidth laser, through optical circulator, wavelength division multiplexer,
Collimator, scanning galvanometer, focusing objective len, annular ultrasonic transducer focus at sample, and scanning galvanometer and ring-shaped ultrasonic change at this time
Energy device is no longer scanned and is motivated by ultrasound operation by computer control, and the backward Brillouin scattering signal of sample is by conglomeration
Mirror focuses, and returns along original optical path；
It is emitted 4. being exported in optical circulator, collimated mirror three, virtual phase control battle array spectrometer VIPA is entered after cylindrical mirror one
One, then through cylindrical mirror two, condenser lens four is incident on after rectangular aperture one and focuses on virtual phase control battle array spectrometer VIPA bis-, pass through
Twice after the frequency selection of spectrometer, emergent light focuses on rectangular aperture two by condenser lens five, then line focus lens six
Become directional light, then parallel optical signal is focused above EMCCD by condenser lens seven, is controlled by computer drives
EMCCD is acquired processing to Brillouin scattering spectrum.
Further, the optical path of subsystem one is connected by optical fiber, condenser lens two, diffraction grating 15, condenser lens three
16, COMES camera 17 forms grating spectrograph package module.
Further, wavelength division multiplexer, optical collimator, narrow linewidth laser, optical circulator and collimating mirror three are light
Fibre connection, constitutes the signal excitation optical path of Brillouin scattering elastogram system.
The present invention has the advantages that 1. are used as a kind of biological tissue elasticity modulus image-forming detecting system device, it is mainly
By the confocal integrated mode of wavelength-division multiplex and optical path by two kinds of Brillouin scattering elastogram and optical coherence elastogram not
Signal optical path with optical system is integrated, and the original of two kinds of different detection systems is realized by computer sequential control system
Position detection.
2. Brillouin scattering elastogram and optical coherence elastogram signal optical path are integrated, it may be implemented two kinds
The in situ detection of detection method reduces influence of the environmental factor in sample moving process to testing inspection result.
3. Brillouin scattering elastogram and optical coherence elastogram signal optical path are integrated, by Brillouin scattering
Elastogram and optical coherence elastogram signal optical path are integrated, and bulk modulus and the coefficient of rigidity may be implemented
In situ detection, it is possible to prevente effectively from influence of the other factors to experimental result in sample moving process, can be independent of each other into
The in situ detection of two kinds of detection modes of row, reducing the intrinsic difference of sample itself, (there may be differences for property of different sampled points itself
It is different) influence to experimental result.
Detailed description of the invention
Fig. 1 is the principle of the present invention figure.
Shown in Fig. 1: wideband light source SLD1, optoisolator 2, photo-coupler 3, collimating mirror 1, optical attenuator 5, condenser lens
One 6, reflecting mirror 7, wavelength division multiplexer 8, optical collimator 9, scanning galvanometer 10, focusing objective len 11, annular ultrasonic transducer 12, collimation
Mirror 2 13, condenser lens 2 14, diffraction grating 15, condenser lens 3 16, COMES camera 17, computer 18, narrow-linewidth laser
Device 19, optical circulator 20, collimating mirror 3 21, cylindrical mirror 22, virtual phase control battle array spectrometer VIPA23, cylindrical mirror 24, rectangular aperture
25, condenser lens 4 26, virtual phase control battle array spectrometer VIPA27, condenser lens 5 28, rectangular aperture 29, condenser lens 6 30,
Condenser lens 7 31, EMCCD32.
Specific embodiment
The present invention relates to a kind of method of achievable Brillouin scattering and optical coherence elastogram in situ detection, features
It is using wavelength-division multiplex and the confocal integrated method of optical path, by Brillouin scattering elastogram and two kinds of optical coherence elastogram
Together, the in situ detection and comparative study of bulk modulus and the coefficient of rigidity may be implemented in the system integration.
The present invention relates to a kind of method of achievable Brillouin scattering and optical coherence elastogram in situ detection, features
It is to use wideband light source SLD1, optoisolator 2, photo-coupler 3, collimating mirror 1, optical attenuator 5, condenser lens 1, instead
Penetrate mirror 7, wavelength division multiplexer 8, optical collimator 9, scanning galvanometer 10, focusing objective len 11, annular ultrasonic transducer 12, collimating mirror two
13, condenser lens 2 14, diffraction grating 15, condenser lens 3 16, COMES camera 17, computer 18, narrow linewidth laser 19,
Optical circulator 20, collimating mirror 3 21, cylindrical mirror 22, virtual phase control battle array spectrometer VIPA23, cylindrical mirror 24, rectangular aperture 25 gather
Focus lens 4 26, virtual phase control battle array spectrometer VIPA27, condenser lens 5 28, rectangular aperture 29, condenser lens 6 30 focus saturating
Mirror 7 31, the method for EMCCD32.
(1) subsystem one: acoustic radiation force optical coherence elastogram
The system core principle is that the ultrasonic action generated using ultrasonic transducer inspires shearing in biological tissue surface
Then wave obtains the speed that shearing wave is propagated in sample surfaces using optical coherence elastography, and then by shearing wave wave
Corresponding relationship between speed and tissue modulus of shearing calculates the modulus of shearing and Young's modulus of sample, can be by following formula meter
It obtains:
E is modulus of shearing in formula, and ρ is sample rate, VSFor shear-wave velocity.Detailed process is as follows for system:
It is 850nm by central wavelength 1. wideband light source SLD1 launches the broadband near infrared light that central wavelength is 850nm
Optoisolator 2, central wavelength is the photo-coupler 3 of 850nm, is divided into the two-beam that phase power ratio is 90:10, wherein power
For 10% collimating mirror one 4 of the reference beam through central wavelength 850nm, optical attenuator 5, condenser lens 1 is incident on reflecting mirror
7, reference beam is after the reflection of reflecting mirror 7 by backtracking at coupler；
2. the sample light that another beam power is 90% passes through wavelength division multiplexer 8, optical collimator 9, scanning from coupler outgoing
Galvanometer 10, focusing objective len 11, annular ultrasonic transducer 12 are incident at sample, scanning galvanometer 10 by computer 18 driver
Control carries out 3-D scanning to sample, and annular ultrasonic transducer 12 is controlled the ultrasonic wave for generating MHz by 18 driver of computer
Excitation generates elastic wave in sample surfaces, and after then sample light and sample tissue are had an effect, back-scattering light is focused
Object lens 11 prolong backtracking after focusing and interfere to photo-coupler 3 and reference light；Sample light and with reference to dry after the interference of light
Optical signal is related to be emitted from another channel of photo-coupler 3, collimated mirror 2 13, condenser lens 2 14 focuses on diffraction grating 15,
Interference light is divided through diffraction grating 15, is focused on COMES camera 17 by condenser lens 3 16, and COMES camera 17 is by computer
The control of 18 drivers is acquired processing to interference signal, can complete the detection function of optical coherence elastogram system at this time
Energy；
(2) subsystem two: Brillouin scattering elastogram
The system core principle is to inspire Brillouin scattering in sample using laser, acoustooptical effect is generated, by scanning
F-P interferometer and photon receiver obtain the Brillouin shift of sample, and then obtain the velocity of sound, and the body of sample is calculated by the velocity of sound
Elasticity modulus.It can be calculated by following formula:
K is modulus of shearing in formula, and ρ is sample rate, VcFor phonon speed.
Detailed process is as follows for system:
3. then the continuous laser that wavelength is 532nm is issued by narrow linewidth laser 19, through optical circulator 20, wavelength-division multiplex
Device 8, collimator, scanning galvanometer 10, focusing objective len 11, annular ultrasonic transducer 12 focus at sample, at this time scanning galvanometer 10
Operation, the backward Brillouin of sample are no longer scanned and are motivated by ultrasound by the control of computer 18 with annular ultrasonic transducer 12
Scattered signal is focused by focusing objective len 11, is returned along original optical path；
It is emitted 4. being exported in optical circulator 20, collimated mirror 3 21, virtual phase control battle array spectrometer is entered after cylindrical mirror 1
VIPA 1 is incident on condenser lens 4 26 after rectangular aperture 1 and focuses on virtual phase control battle array light then through cylindrical mirror 2 24
Spectrometer VIPA 2 27, after the frequency selection through spectrometer twice, emergent light focuses on rectangular aperture two by condenser lens 5 28
29, then line focus lens 6 30 become directional light, then are focused EMCCD32 by 7 31 pairs of parallel optical signals of condenser lens
Above, processing is acquired to Brillouin scattering spectrum by 18 drive control EMCCD32 of computer.
Further, the optical path of subsystem one is connected by optical fiber, condenser lens 2 14, diffraction grating 15, condenser lens
3 16, COMES camera 17 forms grating spectrograph package module.
Further, wavelength division multiplexer 8, optical collimator 9, narrow linewidth laser 19, optical circulator 20 and collimating mirror three
21 be optical fiber connection, constitutes the signal excitation optical path of Brillouin scattering elastogram system.
The present invention relates to a kind of method of achievable Brillouin scattering and optical coherence elastogram in situ detection, features
It is computer sequential control system to realize that two kinds of optical systems were independent of each other work, when optical coherence elastogram system
When system work, computer controls annular ultrasonic transducer sending ultrasonic action and generates shearing wave in sample surfaces, then computer
Scanning galvanometer is driven to carry out image checking.After the detection of optical coherence elastogram is completed, computer drives ring energy ultrasound is changed
Energy device and scanning galvanometer stop working, at this time Brillouin scattering elastogram system starts, complete Brillouin scattering elasticity
Image checking.It is possible thereby to realize the in situ detection and comparative study of bulk modulus and the coefficient of rigidity, sample is avoided
Influence of the intrinsic difference of nature to laboratory test results.
Not limited to this, any change or replacement expected without creative work should all be covered in guarantor of the invention
Within the scope of shield.Therefore, protection scope of the present invention should be determined by the scope of protection defined in the claims.
Claims (3)
1. a kind of method of Brillouin scattering and optical coherence elastogram in situ detection, which comprises the steps of:
(1) subsystem one: acoustic radiation force optical coherence elastogram
The system core principle is that the ultrasonic action generated using ultrasonic transducer inspires shearing wave in biological tissue surface, so
The speed that shearing wave is propagated in sample surfaces is obtained using optical coherence elastography afterwards, and then by shear-wave velocity and group
Modulus of shearing and Young's modulus that the corresponding relationship between modulus of shearing calculates sample are knitted, can be calculated by following formula
It arrives:
E is modulus of shearing in formula, and ρ is sample rate, VSFor shear-wave velocity.Detailed process is as follows for system:
It is 850nm's by central wavelength 1. wideband light source SLD (1) launches the broadband near infrared light that central wavelength is 850nm
Optoisolator (2), central wavelength are the photo-coupler (3) of 850nm, are divided into the two-beam that phase power ratio is 90:10, wherein power
For 10% collimating mirror one (4) of the reference beam through central wavelength 850nm, optical attenuator (5), condenser lens one (6) is incident on
Reflecting mirror (7), reference beam is after reflecting mirror (7) are reflected by backtracking at coupler；
2. the sample light that another beam power is 90% passes through wavelength division multiplexer (8) from coupler outgoing, optical collimator (9), scanning
Galvanometer (10), focusing objective len (11), annular ultrasonic transducer (12) are incident at sample, and scanning galvanometer (10) is by computer (18)
Driver control to sample carry out 3-D scanning, annular ultrasonic transducer (12) by computer (18) driver control produce
The ultrasonic exciting of raw MHz generates elastic wave in sample surfaces, after then sample light and sample tissue are had an effect, back
It is focused after object lens (11) focus to scattering light and prolongs backtracking and interfered to photo-coupler (3) and reference light；Sample light and
It is emitted with reference to the interference light signal after the interference of light from another channel of photo-coupler (3), collimated mirror two (13), condenser lens
Two (14) focus on diffraction grating (15), and interference light is divided through diffraction grating (15), focus on COMES by condenser lens three (16)
On camera (17), COMES camera (17) is acquired processing to interference signal by the control of computer (18) driver, at this time may be used
To complete the detection function of optical coherence elastogram system；
(2) subsystem two: Brillouin scattering elastogram
The system core principle is to inspire Brillouin scattering in sample using laser, generates acoustooptical effect, is done by scanning F-P
Interferometer and photon receiver obtain the Brillouin shift of sample, and then obtain the velocity of sound, and the body elasticity of sample is calculated by the velocity of sound
Modulus.It can be calculated by following formula:
K is modulus of shearing in formula, and ρ is sample rate, VcFor phonon speed.
Detailed process is as follows for system:
3. then the continuous laser that wavelength is 532nm is issued by narrow linewidth laser (19), through optical circulator (20), wavelength-division multiplex
Device (8), collimator, scanning galvanometer (10), focusing objective len (11), annular ultrasonic transducer (12) are focused at sample, are swept at this time
It retouches galvanometer (10) and annular ultrasonic transducer (12) and is no longer scanned and is motivated by ultrasound operation, sample by computer (18) control
The backward Brillouin scattering signal of product is focused by focusing objective len (11), is returned along original optical path；
It is emitted 4. being exported in optical circulator (20), collimated mirror three (21), cylindrical mirror one (22) enters virtual phase control battle array spectrum afterwards
Instrument VIPA mono- (23) is incident on condenser lens four (26) after rectangular aperture one (25) and focuses on void then through cylindrical mirror two (24)
Quasi- phased array spectrometer VIPA bis- (27), after the frequency selection through spectrometer twice, emergent light is poly- by condenser lens five (28)
Coke arrives rectangular aperture two (29), and then line focus lens six (30) become directional light, then by condenser lens seven (31) to directional light
Signal is focused EMCCD (32) above, is carried out by computer (18) drive control EMCCD (32) to Brillouin scattering spectrum
Acquisition process.
2. the method for Brillouin scattering according to claim 1 and optical coherence elastogram in situ detection, feature exists
In, the optical path of subsystem one is connected by optical fiber, condenser lens two (14), diffraction grating (15) 15, condenser lens three (16) 16,
COMES camera (17) 17 forms grating spectrograph package module.
3. the method for Brillouin scattering according to claim 1 and optical coherence elastogram in situ detection, feature exist
In wavelength division multiplexer (8), optical collimator (9), narrow linewidth laser (19), optical circulator (20) and collimating mirror three (21) are equal
For optical fiber connection, the signal excitation optical path of Brillouin scattering elastogram system is constituted.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910638803.2A CN110426373B (en) | 2019-07-16 | 2019-07-16 | In-situ detection method for Brillouin scattering and optical coherence elastography |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910638803.2A CN110426373B (en) | 2019-07-16 | 2019-07-16 | In-situ detection method for Brillouin scattering and optical coherence elastography |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110426373A true CN110426373A (en) | 2019-11-08 |
| CN110426373B CN110426373B (en) | 2021-11-26 |
Family
ID=68409615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910638803.2A Active CN110426373B (en) | 2019-07-16 | 2019-07-16 | In-situ detection method for Brillouin scattering and optical coherence elastography |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110426373B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110879249A (en) * | 2019-11-29 | 2020-03-13 | 南昌航空大学 | System device for measuring limit shear modulus of biological Newtonian fluid |
| CN111466884A (en) * | 2020-04-28 | 2020-07-31 | 北京信息科技大学 | Optical coherent elastic imaging device |
| CN111830134A (en) * | 2020-07-15 | 2020-10-27 | 上海工程技术大学 | Ultrasonic nondestructive testing system |
Citations (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0200028A2 (en) * | 1985-04-08 | 1986-11-05 | International Standard Electric Corporation | Coherent optical fiber communication with frequency-division-multiplexing |
| EP1178580A1 (en) * | 1999-04-13 | 2002-02-06 | Sumitomo Electric Industries, Ltd. | Optical transmitter and optical transmission system comprising the same |
| US20070171402A1 (en) * | 2004-05-01 | 2007-07-26 | Sensornet Limited | Direct measurement of brillouin frequency in destributed optical sensing systems |
| CN200962160Y (en) * | 2006-09-29 | 2007-10-17 | 李志扬 | Imaging device based on active optical phase conjugation |
| CN101144729A (en) * | 2007-09-30 | 2008-03-19 | 南京大学 | Brillouin optical time domain reflection measuring method based on quick fourier transform |
| US20090103931A1 (en) * | 2007-10-19 | 2009-04-23 | Grigoryan Vladimir S | Systems and methods for the coherent non-differential detection of optical communication signals |
| CN101852655A (en) * | 2010-04-13 | 2010-10-06 | 中国计量学院 | Distributed fiber Raman/Brillouin scattering sensor |
| CN103196584A (en) * | 2013-03-12 | 2013-07-10 | 重庆大学 | Measurement method for temperature and stress in fiber and Brillouin optical time domain reflectometer |
| EP2976603A1 (en) * | 2013-03-18 | 2016-01-27 | Omnisens S.A. | Brillouin optical distributed sensing device and method with improved tolerance to sensor failure |
| US20160206194A1 (en) * | 2013-10-11 | 2016-07-21 | Wavelight Gmbh | Diagnosis system and diagnosis method |
| CN105890633A (en) * | 2016-05-24 | 2016-08-24 | 郑州轻工业学院 | Device for measuring Brillouin scattering of sample to be measured under high pressure condition |
| US20170059428A1 (en) * | 2015-09-02 | 2017-03-02 | Lios Technology Gmbh | Device and Method for Spatially Resolved Measurement of Temperature and/or Strain by Brillouin Scattering |
| JP2017120186A (en) * | 2015-12-28 | 2017-07-06 | 日本電信電話株式会社 | Brillouin frequency shift distribution measurement system, brillouin frequency shift distribution measurement device, brillouin frequency shift distribution measurement method, and brillouin frequency shift distribution measurement program |
| CN107764741A (en) * | 2017-09-28 | 2018-03-06 | 南昌航空大学 | A kind of detection means for integrating stimulated Brillouin scattering and optical coherence elastogram |
| CN107907507A (en) * | 2017-09-28 | 2018-04-13 | 南昌航空大学 | A kind of lubricating oil elasticity modulus detection method based on Brillouin scattering spectrum |
| CN108348151A (en) * | 2015-09-02 | 2018-07-31 | 通用医疗公司 | Monitoring characteristic implementation procedure based on biological tissue |
| EP3353502A1 (en) * | 2015-09-22 | 2018-08-01 | Institut Français des Sciences et Technologies des Transports, de l'Amenagement et des Reseaux | Measurement system and temperature and/or shape change sensor using brillouin back-reflection analysis |
| CN108514404A (en) * | 2018-03-28 | 2018-09-11 | 深圳市太赫兹科技创新研究院 | Optical coherence tomography system |
| CN109875504A (en) * | 2019-01-15 | 2019-06-14 | 温州医科大学 | One kind being based on the viscoelastic method of jet-propelled optical coherence elastography non-invasive measurement cornea |
| CN111000532A (en) * | 2019-07-16 | 2020-04-14 | 南昌航空大学 | Oral cavity soft tissue detection device and method based on optical Doppler imaging |
-
2019
- 2019-07-16 CN CN201910638803.2A patent/CN110426373B/en active Active
Patent Citations (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0200028A2 (en) * | 1985-04-08 | 1986-11-05 | International Standard Electric Corporation | Coherent optical fiber communication with frequency-division-multiplexing |
| EP1178580A1 (en) * | 1999-04-13 | 2002-02-06 | Sumitomo Electric Industries, Ltd. | Optical transmitter and optical transmission system comprising the same |
| US20070171402A1 (en) * | 2004-05-01 | 2007-07-26 | Sensornet Limited | Direct measurement of brillouin frequency in destributed optical sensing systems |
| CN200962160Y (en) * | 2006-09-29 | 2007-10-17 | 李志扬 | Imaging device based on active optical phase conjugation |
| CN101144729A (en) * | 2007-09-30 | 2008-03-19 | 南京大学 | Brillouin optical time domain reflection measuring method based on quick fourier transform |
| US20090103931A1 (en) * | 2007-10-19 | 2009-04-23 | Grigoryan Vladimir S | Systems and methods for the coherent non-differential detection of optical communication signals |
| CN101852655A (en) * | 2010-04-13 | 2010-10-06 | 中国计量学院 | Distributed fiber Raman/Brillouin scattering sensor |
| CN103196584A (en) * | 2013-03-12 | 2013-07-10 | 重庆大学 | Measurement method for temperature and stress in fiber and Brillouin optical time domain reflectometer |
| EP2976603A1 (en) * | 2013-03-18 | 2016-01-27 | Omnisens S.A. | Brillouin optical distributed sensing device and method with improved tolerance to sensor failure |
| US20160206194A1 (en) * | 2013-10-11 | 2016-07-21 | Wavelight Gmbh | Diagnosis system and diagnosis method |
| CN108348151A (en) * | 2015-09-02 | 2018-07-31 | 通用医疗公司 | Monitoring characteristic implementation procedure based on biological tissue |
| US20170059428A1 (en) * | 2015-09-02 | 2017-03-02 | Lios Technology Gmbh | Device and Method for Spatially Resolved Measurement of Temperature and/or Strain by Brillouin Scattering |
| EP3139133A1 (en) * | 2015-09-02 | 2017-03-08 | LIOS Technology GmbH | Device and method for local measurement of temperature and/or strain using brillouin scattering |
| EP3353502A1 (en) * | 2015-09-22 | 2018-08-01 | Institut Français des Sciences et Technologies des Transports, de l'Amenagement et des Reseaux | Measurement system and temperature and/or shape change sensor using brillouin back-reflection analysis |
| JP2017120186A (en) * | 2015-12-28 | 2017-07-06 | 日本電信電話株式会社 | Brillouin frequency shift distribution measurement system, brillouin frequency shift distribution measurement device, brillouin frequency shift distribution measurement method, and brillouin frequency shift distribution measurement program |
| CN105890633A (en) * | 2016-05-24 | 2016-08-24 | 郑州轻工业学院 | Device for measuring Brillouin scattering of sample to be measured under high pressure condition |
| CN107907507A (en) * | 2017-09-28 | 2018-04-13 | 南昌航空大学 | A kind of lubricating oil elasticity modulus detection method based on Brillouin scattering spectrum |
| CN107764741A (en) * | 2017-09-28 | 2018-03-06 | 南昌航空大学 | A kind of detection means for integrating stimulated Brillouin scattering and optical coherence elastogram |
| CN108514404A (en) * | 2018-03-28 | 2018-09-11 | 深圳市太赫兹科技创新研究院 | Optical coherence tomography system |
| CN109875504A (en) * | 2019-01-15 | 2019-06-14 | 温州医科大学 | One kind being based on the viscoelastic method of jet-propelled optical coherence elastography non-invasive measurement cornea |
| CN111000532A (en) * | 2019-07-16 | 2020-04-14 | 南昌航空大学 | Oral cavity soft tissue detection device and method based on optical Doppler imaging |
Non-Patent Citations (12)
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110879249A (en) * | 2019-11-29 | 2020-03-13 | 南昌航空大学 | System device for measuring limit shear modulus of biological Newtonian fluid |
| CN110879249B (en) * | 2019-11-29 | 2022-06-03 | 南昌航空大学 | System device for measuring limit shear modulus of biological Newtonian fluid |
| CN111466884A (en) * | 2020-04-28 | 2020-07-31 | 北京信息科技大学 | Optical coherent elastic imaging device |
| CN111466884B (en) * | 2020-04-28 | 2022-10-25 | 北京信息科技大学 | Optical coherent elastography device |
| CN111830134A (en) * | 2020-07-15 | 2020-10-27 | 上海工程技术大学 | Ultrasonic nondestructive testing system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110426373B (en) | 2021-11-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7023558B2 (en) | Acousto-optic monitoring and imaging in a depth sensitive manner | |
| CN110426373A (en) | A kind of method of Brillouin scattering and optical coherence elastogram in situ detection | |
| CA2476174C (en) | Low-coherence interferometric apparatus for light-optical scanning of an object | |
| KR910004225B1 (en) | Method and device for nondestructive evaluation | |
| US8174704B2 (en) | Optical imaging system based on coherence frequency domain reflectometry | |
| US20140293290A1 (en) | Method and System for Compact Optical Coherence Tomography | |
| EP2683289B1 (en) | Multi-channel optical coherence tomography for imaging and temperature and force sensing | |
| US10209226B2 (en) | Photoacoustic microscope apparatus | |
| JP2018507028A (en) | Optical instrument for biomechanical diagnosis of eye diseases | |
| RU2561867C2 (en) | Device and method for optical coherence tomography | |
| CN103175837A (en) | Method and device for detecting defect in matrix | |
| US20050030548A1 (en) | Interferometric optical apparatus and method for measurements | |
| CN110426372A (en) | A kind of sweep-frequency Békésy audiometer Brillouin scattering bulk modulus imaging detection method | |
| JP4094555B2 (en) | Torsional vibration measuring device | |
| CN110772217A (en) | Method for improving signal-to-noise ratio of Brillouin elastography system through interference type optical path | |
| CN104977275B (en) | A kind of OCT image device and method under the ultrasonic field excitation of SBS | |
| CN109674441B (en) | Multi-beam elasticity measurement system and method based on optical switch and micro-lens array | |
| CN109620131B (en) | Common-path micro-lens array multi-beam optical coherence elasticity measurement system and method | |
| JP6917663B2 (en) | Optical interference unit for optical coherence tomography equipment | |
| JP2019147015A (en) | Optical instrument for biomechanical diagnosis of eye disease | |
| JP2017111062A (en) | Optical coherence tomograph | |
| US20160161244A1 (en) | Wavelength encoded multi-beam optical coherence tomography | |
| RU2632993C2 (en) | Fibre-optic switch of laser spectrometer | |
| JP2005106706A (en) | Instrument and method for measuring refractive index and thickness | |
| CN211347940U (en) | Small frequency shift excitation Raman detection device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |