CN110292373A - A kind of high-performance tissue blood flow detection analytical equipment - Google Patents
A kind of high-performance tissue blood flow detection analytical equipment Download PDFInfo
- Publication number
- CN110292373A CN110292373A CN201910668774.4A CN201910668774A CN110292373A CN 110292373 A CN110292373 A CN 110292373A CN 201910668774 A CN201910668774 A CN 201910668774A CN 110292373 A CN110292373 A CN 110292373A
- Authority
- CN
- China
- Prior art keywords
- laser
- speckle
- interface
- blood flow
- subsystem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000001514 detection method Methods 0.000 title claims abstract description 48
- 230000017531 blood circulation Effects 0.000 title claims abstract description 41
- 238000012545 processing Methods 0.000 claims abstract description 77
- 238000003384 imaging method Methods 0.000 claims abstract description 17
- 238000004891 communication Methods 0.000 claims description 18
- 230000013011 mating Effects 0.000 claims description 18
- 230000008081 blood perfusion Effects 0.000 claims description 12
- 241000218691 Cupressaceae Species 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 238000003745 diagnosis Methods 0.000 abstract description 4
- 201000010099 disease Diseases 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 210000003238 esophagus Anatomy 0.000 abstract description 3
- 230000002757 inflammatory effect Effects 0.000 abstract description 3
- 238000002324 minimally invasive surgery Methods 0.000 abstract description 3
- 230000006870 function Effects 0.000 description 8
- 238000010586 diagram Methods 0.000 description 7
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 230000005540 biological transmission Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 230000010412 perfusion Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 208000012322 Raynaud phenomenon Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 208000030961 allergic reaction Diseases 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000009940 knitting Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000004089 microcirculation Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000001951 hemoperfusion Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physiology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention discloses a kind of high-performance tissue blood flow detection analytical equipments, including laser and control circuit subsystem, tissue to be checked, laser speckle processing subsystem, center control subsystem, the output end of the laser and control circuit subsystem output laser simultaneously acts on the detection tissue generation speckle image, the speckle image inputs the input terminal of the laser speckle processing subsystem, and the input/output terminal of the laser speckle processing subsystem couples with the cooperation of the input/output terminal of the center control subsystem.The present invention uses high-speed commercial cmos imaging equipment, realize image rate grade image taking speed, the application of the medical domain of real-time observation blood flow variation is come true, and the possibility being used cooperatively with endoscope is provided, the diagnosis basis in terms of providing blood flow for Minimally Invasive Surgery, esophagus inflammatory bowel class disease etc..
Description
Technical field
The present invention proposes a kind of high-performance tissue blood flow detection analytical equipment, is related to swashing for tissue blood perfusion
Light imaging detection device belongs to the advanced medical diagnostic imaging equipment technical field in medical instrument.
Background technique
The detection method of the blood perfusion of human organ surface texture has very much.It is common such as fluorescence, isotope, tracer,
Infrared ray, ultrasonic wave and laser imaging etc..Current relatively advanced and widely applied detection method is laser imaging detection technique.
Laser blood perfusion imaging technique have it is not damaged, can continuously measure tissue microvascular hemoperfusion amount, wide adaptation range, behaviour
Make many advantages, such as easy.Therefore the technology is in the diagnosis of each section's disease of clinical medicine, the evaluation and medical biotechnology of lesion and damage
The general application of factory is obtained in research, as the treatment evaluation of dermatoma, the clinical assessment of burn degree, cardio-vascular clinical are treated
Evaluation, the treatment of rheumatism are assessed and to the clinical evaluations etc. in surgical operation.
Currently, blood perfusion laser imager supplier soil will include auspicious (Perimcd) company of Sweden's pa, Britain in the world
Mole (Moor Instnuments) company, the U.S. praise moral (Transonic) company and Australia angstrom moral instrument (AD
Istruments) company etc..Their the early developments blood flowmeter of contact, later developed to contactless, was scanned into a little
As mode and line scanning imagery mode, current last word can not only measure tissue blood flow's speed, additionally it is possible to measure tissue
The series such as blood oxygen saturation has the blood flow parameter of medical research value, and can visit for different tissues replacement is corresponding
Head carries out the measurement of blood flow.
The research that the country strangles Perfusion for laser more is concentrated mainly on testing principle and method, such as: patent
CN101485565A discloses a kind of laser speckle blood current imaging and analyzing method, and patent CN102357033A discloses a kind of laser
Speckle blood flow imaging processing system and method, patent CN102429650A disclose a kind of laser speckle blood flow imaging contrast analysis
Method, patent CN2019101198258 disclose a kind of measurement of combination ultrasonic Doppler fluid velocity and laser speckle two-dimensional flow
Measuring method is perfused in the SkBF of fast real-time monitoring, and patent CN205514579 U discloses a kind of for laser speckle blood
The quantitative imaging device of flow velocity degree.Wherein patent CN201520748353.X discloses a kind of microcirculation in human body blood perfusion detection
Instrument, due to, as detector, being only applicable in the blood of monitoring lesser fingers and toes of body surface area etc. using photodiode
Liquid microcirculation.
Summary of the invention
The technical problem to be solved by the present invention is to overcome the deficiencies of existing technologies, low cost, lightweight, high-performance are provided
Laser perfusion imagingt equipment, the present invention use high-speed commercial cmos imaging equipment, realize image rate grade image taking speed, will be real
When observation blood flow variation the application of medical domain (such as group etc. is waited in allergic reaction, raynaud's sign) come true, and provide
The possibility being used cooperatively with endoscope, the diagnosis in terms of providing blood flow for Minimally Invasive Surgery, esophagus inflammatory bowel class disease etc.
Foundation.
The present invention adopts the following technical scheme: a kind of high-performance tissue blood flow detection analytical equipment, which is characterized in that
Including laser and control circuit subsystem, tissue to be checked, laser speckle processing subsystem, center control subsystem, the laser
And the output end of control circuit subsystem exports laser and acts on the detection tissue and generates speckle image, the speckle image
Input the input terminal of the laser speckle processing subsystem, the input/output terminal of the laser speckle processing subsystem and it is described in
The input/output terminal of heart control subsystem cooperates connection.
As a kind of preferred embodiment, the laser and control circuit subsystem include laser control circuit PCB, infrared
Laser diode, red laser diode, the first even mating plate, the second even mating plate, the output end point of the laser control circuit PCB
Be not cooperatively connected the input terminal of the infra-red laser diode, the input terminal of the red laser diode, the infrared laser
The output end of diode is cooperatively connected the first even mating plate, and the output end of the red laser diode is cooperatively connected described the
Two even mating plates.
As a kind of preferred embodiment, the laser that laser diode issues is converted into certain area by diffuser
Equally distributed laser beam, the device that is split are guided out equipment, are radiated on a region in tissue, then by human body group
The reflection such as static substance and haemocyte in knitting is scattered back the laser speckle come, arrives at image sensor by optical lens group
Array is converted into digital electronic signal, generates blood perfusion image using the signal processing circuit on fpga chip,
It is shown in LCD display or PC equipment.
As a kind of preferred embodiment, the infra-red laser diode is used to the infrared laser that launch wavelength is 785nm
Laser is detected as blood perfusion；The red laser diode is used to the red laser that launch wavelength is 650nm and is used as detection
Area identification laser；The infrared laser that the infra-red laser diode is launched projects irradiation by the described first even mating plate
When to detection position, hot spot at a 20cmx 15cm rectangular area；The red laser diode is launched described red
When color laser is irradiated to detection position by the described second even mating plate injection, hot spot at a 20cmx 15cm rectangular area.
As a kind of preferred embodiment, the center control subsystem include main control PCB, imaging sensor PCB,
TFT touch screen, switch control knob, the main control PCB respectively with described image sensor PCB, the TFT touch screen, institute
Switch control knob's communication connection is stated, the switch control knob is mounted in power supply of the case surface for startup and shutdown and opens
It closes.
As a kind of preferred embodiment, the main control PCB uses STM32F746 microcontroller, the STM32F746
Microcontroller includes DCMI interface, TFT interface and GPIO interface, and the STM32F746 microcontroller passes through the DCMI interface
With the color image sensor PCB communication connection, the STM32F746 microcontroller passes through the TFT interface and the TFT
Touch screen communication connection, the STM32F746 microcontroller are connected by the GPIO interface and switch control knob communication
It connects.
As a kind of preferred embodiment, the laser speckle processing subsystem includes speckle processing core plate, at speckle
Motherboard, speckle camera daughter board, SSD hard disk are managed, the input/output terminal of the speckle processing core plate and speckle processing are female
The input/output terminal of plate cooperates communication connection, and the input/output terminal and the speckle of the speckle camera daughter board handle motherboard
Input/output terminal cooperates communication connection, the input/output terminal of the input/output terminal of the SSD hard disk and speckle processing motherboard
Cooperate communication connection.
As a kind of preferred embodiment, the speckle camera daughter board includes the CMOS for acquiring laser speckle image
Imaging sensor, the cmos image sensor and speckle processing motherboard cooperate communication connection；The cmos image sensing
Device uses Sony IMX174 image chip.
As a kind of preferred embodiment, the speckle processing core plate uses Zynq XCZU9EG chip, the Zynq
XCZU9EG chip include four core ARM Cortex-A53 application microprocessors, double-core ARM Cortex-R5 real-time processor,
Fpga chip, the Cortex-R5 real-time processor and the fpga chip cooperate communication connection, and the fpga chip passes through company
It connects Cypress USB3 output circuit chip and cooperates external PC equipment, the Cortex-A53 application microprocessor is embedded in Linux
Operating system, the hardware carrier as operation application software system.
As a kind of preferred embodiment, the speckle processing motherboard includes SATA hard disc interface, Display Port figure
As display interface device, Ethernet interface, USB2.0 interface, USB3.0 interface, UART interface, connecing on the speckle processing motherboard
Mouth constitutes appliance computer system with the Cortex-A53 application microprocessor, for running LPI user interface software.
As a kind of preferred embodiment, the LPI user interface software is the application software system operated in PC equipment
System, the laser speckle image for generating speckle processing circuit is shown, and provides an operation interface, makes user
The operation of equipment is controlled by mouse/keyboard.
Advantageous effects of the invention: first, benefit of the invention is that high performance tissue blood flow detection
Analytical equipment is capable of the blood flow variation of convenient and efficient, inexpensive, innoxious detection tissue；Second, benefit of the invention exists
There is up to 160 frames/second tissue speckle image acquisition in high performance tissue blood flow detection analytical equipment, deposit
Storage, transmission and processing capacity can work in image rate grade, doctor helped fast and accurately to diagnose；Third, the present invention mention
For a kind of high performance tissue blood flow detection analytical equipment, it is mainly used in the medical domain of observation blood flow variation in real time
(such as group etc. is waited in allergic reaction, raynaud's sign), and the possibility being used cooperatively with endoscope is provided, it is Minimally Invasive Surgery, esophagus
Inflammatory bowel class disease etc. provides the diagnosis basis in terms of blood flow.
Detailed description of the invention
Fig. 1 is a kind of entire block diagram of high-performance tissue blood flow detection analytical equipment of the invention.
Fig. 2 is a kind of operation principle schematic diagram of high-performance tissue blood flow detection analytical equipment of the invention.
Fig. 3 is a kind of connection signal of the first embodiment of high-performance tissue blood flow detection analytical equipment of the invention
Figure.
Fig. 4 is the laser and control circuit subsystem of a kind of high-performance tissue blood flow detection analytical equipment of the invention
Connection schematic diagram.
Fig. 5 is a kind of connection of the center control subsystem of high-performance tissue blood flow detection analytical equipment of the invention
Schematic diagram.
Fig. 6 is a kind of laser speckle processing subsystem of high-performance tissue blood flow detection analytical equipment of the invention
The connection schematic diagram of first embodiment.
Fig. 7 is the laser and control circuit subsystem of a kind of high-performance tissue blood flow detection analytical equipment of the invention
Connection schematic diagram.
Fig. 8 is a kind of connection signal of the second embodiment of high-performance tissue blood flow detection analytical equipment of the invention
Figure.
Fig. 9 is a kind of laser speckle processing subsystem of high-performance tissue blood flow detection analytical equipment of the invention
The connection schematic diagram of second embodiment.
Specific embodiment
The invention will be further described below in conjunction with the accompanying drawings.Following embodiment is only used for clearly illustrating the present invention
Technical solution, and not intended to limit the protection scope of the present invention.
Specific embodiment 1:
The invention discloses a kind of high-performance tissue blood flow detection analytical equipments.As shown in Figure 1, the device is divided into two
Point: front end unit and backend unit.The front end unit mainly has Laser emission and speckle image intake processing unit function.
The backend unit is mainly user interface elements.
The backend unit is common a high definition LCD display and a PC equipment.What is run in PC equipment is that LPI is answered
With software, a user interface is mainly provided, so that user is issued order come before controlling the operation of front end unit and observation
The blood perfusion image that end unit obtains.
Front end unit is mainly by center control subsystem, laser speckle processing subsystem and laser and control circuit subsystem
Composition.As shown in Figure 2.
The working principle of the front end unit is: the laser that laser diode issues is converted by diffuser in certain face
Equally distributed laser beam in product, the device that is split are guided out equipment, are radiated on a region in tissue.By in tissue
Static substance and the reflection such as haemocyte or be scattered back the laser come, pass through optical lens group and arrive at image sensor array, quilt
It is converted into digital electronic signal, generates blood perfusion figure using the signal processing circuit on FPGA (field programmable gate array)
Picture is shown on an lcd display.As shown in Figure 3.
Laser and control system include laser control circuit PCB, infra-red laser diode, red laser diode, first
Even mating plate and the second even mating plate.Construction is as shown in Figure 4.The infra-red laser diode is capable of the infrared of launch wavelength 785nm and is swashed
Light detects laser as blood perfusion, and power 80mW belongs to laser safety grade 3b.The red laser diode can emit
Power is that the conduct detection zone of the red laser (wavelength 650nm) of 5mW identifies laser.The infrared laser and red laser are each
From projected by an even mating plate (Diffuser) be irradiated to detection position when, hot spot at a 20cmx 15cm rectangle region
Domain.Laser belongs to security level 1 when projecting from equipment, will not constitute any injury to eyes, skin and other tissues.
The center control subsystem includes main control PCB, common color imaging sensor PCB, TFT touch screen and opens
Close control button.As shown in Figure 5.The main control PCB surrounds STM32F746G Discovery board design, and has
DCMI, TFT and GPIO interface.
The STM32F46 is ARM Coretext-M7 microcontroller (MCU), can work in 233MHz, be integrated with L1
Fast cache, 1 M byte flash memory and 240 K byte RAM, built-in DSP (containing FPU) unit and Chrom-ART image procossing add
Fast device, and DCMI(digital camera interface is provided), the interfaces such as TFT.
The common image sensor PCB selects STM32F4DIS-CAM image sensor board, has 1.3M pixel (1280
1024@15fps of x) digital camera module.The module is integrated with an OminiVision OV9655 imaging sensor,
Provide DCMI interface, the TFT touch screen selects the RK043FN48H-CT672B of ROCKTECH production, belong to condenser type,
LCD-TFT colour shows that screen size is 4.3 inches, resolution ratio 480x272.The switch control knob is mounted in outer
Shell surface is used for the power switch of startup and shutdown.
Embedded software refers to that panel controls embedded software, operates in the interaction of STM32F746 MCU realization and PC machine,
The switching on and shutting down of control system, system mode are shown, common camera image obtains etc..
The laser speckle processing subsystem include speckle processing core plate, speckle processing motherboard, speckle camera daughter board,
SSD hard disk etc..As shown in Figure 6.The speckle image camera daughter board mainly places one for acquiring laser speckle image
Cmos image sensor, Sony IMX174 image chip.It is as shown in table 1 that the chip adopts technical parameter:
1. laser speckle image sensor of table
| Resolution ratio | 1920 x 1200 |
| Pixel size | 5.86 μm square |
| Frame rate | 160 frames/s |
| ADC | 10bit or 12bit |
Data and control interface are wired on speckle processing motherboard on the IMX174 image chip, then pass through motherboard
On data-interface be connected on fpga chip.
The speckle processing core plate uses TE0808-04 PCB module.Central module on the plate is a U.S.
The high-end Zynq UltraScale+ EG MPSoC chip of one of Xilinx company.As shown in fig. 7, including following on the chip
Chief component: four core ARM Cortex-A53 application microprocessors, highest frequency 1.5GHz always；Double-core ARM
Cortex-R5 real-time processor, highest frequency 600MHz always；GPU；Computer external circuit；FPGA.
(SuSE) Linux OS is embedded on the Cortex-A53 microprocessor, it is hard that application software system may operate in this
On part.Main speckle data processing function is all realized on FPGA.One embedded application software will operate in Cortex-R5
On processor, it is mainly responsible for and the interaction of panel control subsystem, such as reception control command, returning equipment state etc..It is same
When be also responsible for the parameter configuration of the upper high speed processing unit of FPGA and the operation of function control and laser controls etc..
The laser speckle data processing circuit is characterized in: fpga chip provide high speed, concurrent operation ability and
Can neatly more new algorithm ability.Wherein data processing circuit is made of multiple processing channels, and concurrent working is high
Rate.Data processing circuit needs a large amount of memory headroom to store operational data, and the internal storage location in fpga chip is inadequate
, therefore high-speed internal memory unit is set on circuit boards for the use of data operation circuit.Data processing circuit will use hardware
Circuit description language is realized.The data/control signals flow graph of speckle processing circuit is shown in Fig. 7.
The original speckle image data of the speckle camera daughter board acquisition are passed to FPGA processing, and the speckle image of generation is logical
Cypress USB3 output circuit chip is crossed to be transferred on PC.Data processing circuit on FPGA is realized using VHDL.
The speckle processing circuit motherboard is in addition to controlling subsystem for speckle camera daughter board, speckle processing core plate, panel
System links together, additionally provide common SATA hard disc interface in a PC machine, DisplayPort image display interface,
The interfaces such as Ethernet interface, USB2.0, USB3.0, UART, the four core Cortex-A53 processing on these interfaces and Zynq chip
Device together forms an appliance computer system, can run LPI user interface software.
The LPI user interface software subsystem is the application software system operated on PC, by speckle processing electricity
The laser speckle image that road generates is shown, and provides an operation interface, so that user is passed through mouse/keyboard to control
The operation of equipment.The software systems will mainly include following components: USB3.0 image-driven program, USB2.0 image drive
Dynamic program, serial port driver etc..
The USB3.0 image-driven program is responsible for would operate in 360MB/s from front end receiver speckle image data, high speed
Data transmission bauds be this software significant challenge to be faced.It can be transformed on the basis of on the driver that Cypress is provided
It forms.The USB2.0 image-driven program is responsible for from front end receiver common color image data.The serial port driver
It is responsible for Transmission system operational order and user operation commands to front end, and the order feedback data and status data of receiving front-end.
The user interface is mainly with the following functions: providing GUI, the operating status of instant playback front end unit, instant playback speckle
Original image, the instant data for display common color image, receiving user operation commands, showing specified location in user, storage figure
Picture.
Specific embodiment 2:
The invention discloses a kind of high-performance tissue blood flow detection analytical equipments.As shown in Figure 1, the device mainly have it is sharp
Light emitting and speckle image absorb processing unit function.Mainly by center control subsystem, laser speckle processing subsystem and swash
Light and control circuit subsystem composition.Its working principle is that: the laser that laser diode issues is converted by diffuser one
Determine equally distributed laser beam in area, the device that is split is guided out equipment, is radiated on a region in tissue.By group
The reflection such as static substance and haemocyte in knitting is scattered back the laser come, arrives at image sensor battle array by optical lens group
Column, are converted into digital electronic signal, generate blood using the signal processing circuit on FPGA (field programmable gate array)
Perfusion image, shows on touch-screen display.As shown in Figure 8.
Laser and control system include laser control circuit PCB, infra-red laser diode, red laser diode, first
Even mating plate and the second even mating plate.Construction is as shown in Figure 4: the infra-red laser diode is capable of the infrared of launch wavelength 785nm and is swashed
Light detects laser as blood perfusion, and power 80mW belongs to laser safety grade 3b.The red laser diode can emit
Power is that the conduct detection zone of the red laser (wavelength 650nm) of 5mW identifies laser.
The infrared laser and red laser are projected each by an even mating plate (Diffuser) is irradiated to detection position
When, hot spot at a 20cmx 15cm rectangular area.Laser from equipment project when belong to security level 1, to eyes, skin and
Other tissues will not constitute any injury.
The center control subsystem includes main control PCB, common color imaging sensor PCB, TFT touch screen and switch
Control button.As shown in Figure 5.The main control PCB surrounds STM32F746G Discovery board design, and has
DCMI, TFT and GPIO interface.The STM32F46 is ARM Coretext-M7 microcontroller (MCU), can be worked
233MHz, is integrated with L1 fast cache, 1 M byte flash memory and 240 K byte RAM, built-in DSP (containing FPU) unit and
Chrom-ART image procossing accelerator, and DCMI(digital camera interface is provided), the interfaces such as TFT.The common image sensor
PCB selects STM32F4DIS-CAM image sensor board, the digital camera with 1.3M pixel (1280 x, 1024@15fps)
Head module.The module is integrated with an OminiVision OV9655 imaging sensor, provides DCMI interface, the TFT touching
The RK043FN48H-CT672B that screen selects ROCKTECH production is touched, belongs to condenser type, LCD-TFT colour is shown, screen size is
4.3 inches, resolution ratio 480x272.
The switch control knob is mounted in power switch of the case surface for startup and shutdown.The embedded software
Part refers to that panel controls embedded software, operates in the interaction of STM32F746 MCU realization and PC machine, the switch of control system
Machine, system mode are shown, common camera image obtains etc..
The laser speckle processing subsystem include speckle processing core plate, speckle processing motherboard, speckle camera daughter board,
SSD hard disk etc..As shown in Figure 9.The speckle image camera daughter board mainly places one for acquiring laser speckle image
Cmos image sensor, Sony IMX174 image chip.It is as shown in table 1 that the chip adopts technical parameter: the IMX174 figure
As data and control interface are wired on speckle processing motherboard on chip, then connected by data-interface on motherboard
It arrives.
The speckle processing core plate using German Trenz Electronic TE0808-04 PCB module.It should
Central module on plate is a high-end Zynq UltraScale+ EG MPSoC chip of an Xilinx company, the U.S..Such as
Shown in Fig. 7, include following chief component on the chip: four core ARM Cortex-A53 application microprocessors, highest is always
Frequency 1.5GHz；Double-core ARM Cortex-R5 real-time processor, highest frequency 600MHz always；GPU；Computer external electricity
Road；FPGA.
(SuSE) Linux OS is embedded on the Cortex-A53 microprocessor, it is hard that application software system may operate in this
On part.Main speckle data processing function is all realized on FPGA.One embedded application software will operate in Cortex-R5
On processor, it is mainly responsible for and the interaction of panel control subsystem, such as reception control command, returning equipment state etc..It is same
When be also responsible for the parameter configuration of the upper high speed processing unit of FPGA and the operation of function control and laser controls etc..
The laser speckle data processing circuit is characterized in: fpga chip provide high speed, concurrent operation ability and
Can neatly more new algorithm ability.Wherein data processing circuit is made of multiple processing channels, and concurrent working is high
Rate.Data processing circuit needs a large amount of memory headroom to store operational data, and the internal storage location in fpga chip is inadequate
, therefore high-speed internal memory unit is set on circuit boards for the use of data operation circuit.Data processing circuit will use hardware
Circuit description language is realized.The data/control signals flow graph of speckle processing circuit is shown in Fig. 7.
The original speckle image data of the speckle camera daughter board acquisition are passed to FPGA processing, and the speckle image of generation is logical
Cypress USB3 output circuit chip is crossed to be transferred in ARM microprocessor system.Data processing circuit on FPGA uses
VHDL is realized.As shown in Figure 9.The speckle processing circuit motherboard is in addition to by speckle camera daughter board, speckle processing core plate, face
Plate control subsystem links together, and additionally provides SATA hard disc interface, DisplayPort image display interface, Ethernet
The interfaces such as interface, USB2.0, USB3.0, UART, four core Cortex-A53 processors on these interfaces and Zynq chip are together
It constitutes an appliance computer system, LPI user interface software can be run.
The LPI user interface software subsystem is the application software system operated in 4 core ARM microprocessor systems
System, the laser speckle image that speckle processing circuit generates is shown, and provide an operation interface, passes through user
Mouse/keyboard controls the operation of equipment.The software systems will mainly include following components: USB3.0 image-driven journey
Sequence, USB2.0 image-driven program, serial port driver etc..
The USB3.0 image-driven program is responsible for would operate in 360MB/s from front end receiver speckle image data, high speed
Data transmission bauds be this software significant challenge to be faced.It can be transformed on the basis of on the driver that Cypress is provided
It forms.The USB2.0 image-driven program is responsible for from front end receiver common color image data.The serial port driver
It is responsible for Transmission system operational order and user operation commands to front end, and the order feedback data and status data of receiving front-end.
The user interface is mainly with the following functions: providing GUI, the operating status of instant playback front end unit, instant playback speckle
Original image, the instant data for display common color image, receiving user operation commands, showing specified location in user, storage figure
Picture.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, without departing from the technical principles of the invention, several improvement and deformations can also be made, these improvement and deformations
Also it should be regarded as protection scope of the present invention.
Claims (10)
1. a kind of high-performance tissue blood flow detection analytical equipment, which is characterized in that including laser and control circuit subsystem,
The output end of tissue to be checked, laser speckle processing subsystem, center control subsystem, the laser and control circuit subsystem is defeated
It laser and acts on the detection tissue out and generates speckle image, the speckle image inputs the laser speckle processing subsystem
Input terminal, the input/output terminal of the laser speckle processing subsystem and the input/output terminal of the center control subsystem are matched
Close connection.
2. a kind of high-performance tissue blood flow detection analytical equipment according to claim 1, which is characterized in that described to swash
Light and control circuit subsystem include laser control circuit PCB, infra-red laser diode, red laser diode, the first even light
Piece, the second even mating plate, the output end of the laser control circuit PCB are respectively cooperating with the input for connecting the infra-red laser diode
It holds, the input terminal of the red laser diode, the output end mating connection first even light of the infra-red laser diode
Piece, the output end mating connection second even mating plate of the red laser diode.
3. a kind of high-performance tissue blood flow detection analytical equipment according to claim 2, which is characterized in that described red
Outer laser diode is used to emit infrared laser as blood perfusion and detects laser；The red laser diode is used to emit red
Color laser identifies laser as detection zone；The infrared laser that the infra-red laser diode is launched passes through described first
When even mating plate injection is irradiated to detection position, hot spot is at an infrared laser spot area；The red laser diode transmitting
When the red laser out is irradiated to detection position by the described second even mating plate injection, hot spot is at one and described infrared sharp
The identical red laser spot area of light spot area.
4. a kind of high-performance tissue blood flow detection analytical equipment according to claim 1, which is characterized in that in described
Heart control subsystem includes main control PCB, imaging sensor PCB, TFT touch screen, switch control knob, the main control PCB
Respectively with described image sensor PCB, the TFT touch screen, switch control knob's communication connection, the switch control pressed
Button is mounted in power switch of the case surface for startup and shutdown.
5. a kind of high-performance tissue blood flow detection analytical equipment according to claim 4, which is characterized in that the master
It controls PCB and uses STM32F746 microcontroller, the STM32F746 microcontroller includes DCMI interface, TFT interface and GPIO
Interface, the STM32F746 microcontroller are described by the DCMI interface and described image sensor PCB communication connection
STM32F746 microcontroller passes through the TFT interface and the TFT touch screen communication connection, the STM32F746 microcontroller
Pass through the GPIO interface and switch control knob's communication connection.
6. a kind of high-performance tissue blood flow detection analytical equipment according to claim 1, which is characterized in that described to swash
Light speckle processing subsystem include speckle processing core plate, speckle processing motherboard, speckle camera daughter board, SSD hard disk, it is described dissipate
The input/output terminal of the input/output terminal of spot processing core plate and speckle processing motherboard cooperates communication connection, and the speckle is taken the photograph
As chieftain's plate input/output terminal and the speckle processing motherboard input/output terminal cooperate communication connection, the SSD hard disk
The input/output terminal of input/output terminal and speckle processing motherboard cooperates communication connection.
7. a kind of high-performance tissue blood flow detection analytical equipment according to claim 6, which is characterized in that described to dissipate
Spot camera daughter board includes the cmos image sensor for acquiring laser speckle image, the cmos image sensor with it is described
Speckle handles motherboard and cooperates communication connection；The cmos image sensor uses Sony IMX174 image chip.
8. a kind of high-performance tissue blood flow detection analytical equipment according to claim 6, which is characterized in that described to dissipate
Spot processing core plate uses Zynq XCZU9EG chip, and the Zynq XCZU9EG chip includes that four core ARM Cortex-A53 are answered
With microprocessor, double-core ARM Cortex-R5 real-time processor, fpga chip, the Cortex-R5 real-time processor with it is described
Fpga chip cooperates communication connection, and the fpga chip cooperates external display by connection Cypress USB3 output circuit chip
Equipment, the Cortex-A53 application microprocessor are embedded in (SuSE) Linux OS, and the hardware as operation application software system carries
Body.
9. a kind of high-performance tissue blood flow detection analytical equipment according to claim 8, which is characterized in that described to dissipate
Spot processing motherboard include SATA hard disc interface, Display Port image display interface, Ethernet interface, USB2.0 interface,
USB3.0 interface, UART interface, the speckle handle interface and Cortex-A53 application microprocessor composition on motherboard
Appliance computer system, for running LPI user interface software.
10. a kind of high-performance tissue blood flow detection analytical equipment according to claim 9, which is characterized in that described
LPI user interface software is application software system, and the laser speckle image for generating speckle processing circuit is shown, and
And an operation interface is provided, so that user is passed through mouse/keyboard to control the operation of equipment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910668774.4A CN110292373A (en) | 2019-07-23 | 2019-07-23 | A kind of high-performance tissue blood flow detection analytical equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910668774.4A CN110292373A (en) | 2019-07-23 | 2019-07-23 | A kind of high-performance tissue blood flow detection analytical equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110292373A true CN110292373A (en) | 2019-10-01 |
Family
ID=68031695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910668774.4A Pending CN110292373A (en) | 2019-07-23 | 2019-07-23 | A kind of high-performance tissue blood flow detection analytical equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110292373A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110786833A (en) * | 2019-12-03 | 2020-02-14 | 南昌航空大学 | Device for detecting and projecting skin tissue wound in real time by laser speckle |
Citations (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1731952A (en) * | 2002-12-30 | 2006-02-08 | 皇家飞利浦电子股份有限公司 | Analysis apparatus and method |
| CN101156778A (en) * | 2007-11-06 | 2008-04-09 | 浙江大学 | Dual-color laser scanning type medical vein display equipment |
| CN202409857U (en) * | 2011-12-29 | 2012-09-05 | 河南省正骨研究院 | Non-contact infrared detection-control intelligent thermal-radiation physiotherapeutic instrument |
| US20120277559A1 (en) * | 2009-12-08 | 2012-11-01 | Matthias Kohl-Bareis | Apparatus for Measuring Blood Parameters |
| KR20150060341A (en) * | 2013-11-26 | 2015-06-03 | 한국전기연구원 | Buit-in image senser speckle endoscope |
| CN104887216A (en) * | 2015-06-10 | 2015-09-09 | 上海大学 | Multi-light-beam coherent human body skin perfusion imaging system and method |
| CN105286785A (en) * | 2014-07-25 | 2016-02-03 | 美国科视数字系统公司 | Multispectral medical imaging devices and methods thereof |
| US20160220129A1 (en) * | 2015-02-04 | 2016-08-04 | General Electric Company | Systems and methods for quantitative microcirculation state monitoring |
| CN107854116A (en) * | 2017-11-15 | 2018-03-30 | 上海交通大学 | A kind of oral soft tissue metabolism monitoring system and method |
| CN107981855A (en) * | 2017-12-29 | 2018-05-04 | 深圳开立生物医疗科技股份有限公司 | A kind of blood flow imaging device and endoscope |
| WO2018126114A2 (en) * | 2016-12-29 | 2018-07-05 | Vanderbilt University | Methods and apparatus for intraoperative assessment of parathyroid gland vascularity using laser speckle contrast imaging and applications of same |
| WO2019045971A1 (en) * | 2017-08-28 | 2019-03-07 | East Carolina University | Multi-spectral physiologic visualization (mspv) using laser imaging methods and systems for blood flow and perfusion imaging and quantification in an endoscopic design |
| CN109820480A (en) * | 2019-02-22 | 2019-05-31 | 南京航空航天大学 | A kind of endogenous optical signal and multi-wavelength flow imaging system |
| CN109924969A (en) * | 2019-04-19 | 2019-06-25 | 优谱激光科技(南京)有限公司 | A kind of laser imaging blood perfusion detection device with light probe |
| CN211484558U (en) * | 2019-07-23 | 2020-09-15 | 优谱激光科技(南京)有限公司 | High-performance human tissue blood flow detection and analysis device |
-
2019
- 2019-07-23 CN CN201910668774.4A patent/CN110292373A/en active Pending
Patent Citations (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1731952A (en) * | 2002-12-30 | 2006-02-08 | 皇家飞利浦电子股份有限公司 | Analysis apparatus and method |
| CN101156778A (en) * | 2007-11-06 | 2008-04-09 | 浙江大学 | Dual-color laser scanning type medical vein display equipment |
| US20120277559A1 (en) * | 2009-12-08 | 2012-11-01 | Matthias Kohl-Bareis | Apparatus for Measuring Blood Parameters |
| CN202409857U (en) * | 2011-12-29 | 2012-09-05 | 河南省正骨研究院 | Non-contact infrared detection-control intelligent thermal-radiation physiotherapeutic instrument |
| KR20150060341A (en) * | 2013-11-26 | 2015-06-03 | 한국전기연구원 | Buit-in image senser speckle endoscope |
| CN105286785A (en) * | 2014-07-25 | 2016-02-03 | 美国科视数字系统公司 | Multispectral medical imaging devices and methods thereof |
| US20160220129A1 (en) * | 2015-02-04 | 2016-08-04 | General Electric Company | Systems and methods for quantitative microcirculation state monitoring |
| CN104887216A (en) * | 2015-06-10 | 2015-09-09 | 上海大学 | Multi-light-beam coherent human body skin perfusion imaging system and method |
| WO2018126114A2 (en) * | 2016-12-29 | 2018-07-05 | Vanderbilt University | Methods and apparatus for intraoperative assessment of parathyroid gland vascularity using laser speckle contrast imaging and applications of same |
| WO2019045971A1 (en) * | 2017-08-28 | 2019-03-07 | East Carolina University | Multi-spectral physiologic visualization (mspv) using laser imaging methods and systems for blood flow and perfusion imaging and quantification in an endoscopic design |
| CN107854116A (en) * | 2017-11-15 | 2018-03-30 | 上海交通大学 | A kind of oral soft tissue metabolism monitoring system and method |
| CN107981855A (en) * | 2017-12-29 | 2018-05-04 | 深圳开立生物医疗科技股份有限公司 | A kind of blood flow imaging device and endoscope |
| CN109820480A (en) * | 2019-02-22 | 2019-05-31 | 南京航空航天大学 | A kind of endogenous optical signal and multi-wavelength flow imaging system |
| CN109924969A (en) * | 2019-04-19 | 2019-06-25 | 优谱激光科技(南京)有限公司 | A kind of laser imaging blood perfusion detection device with light probe |
| CN211484558U (en) * | 2019-07-23 | 2020-09-15 | 优谱激光科技(南京)有限公司 | High-performance human tissue blood flow detection and analysis device |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110786833A (en) * | 2019-12-03 | 2020-02-14 | 南昌航空大学 | Device for detecting and projecting skin tissue wound in real time by laser speckle |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20210243425A1 (en) | Optical imaging system and methods thereof | |
| EP2945529A1 (en) | Systems and methods for noninvasive health monitoring | |
| US8351666B2 (en) | Portable imaging system having a seamless form factor | |
| CN103505222A (en) | Miniaturized multi-spectral imager for real-time tissue oxygenation measurement | |
| CN105025804A (en) | Consistent sequential ultrasound acquisitions for intra-cranial monitoring | |
| CN102871645A (en) | Near-infrared imaging ultrasonic vascular therapeutic apparatus | |
| CN205251572U (en) | Intelligent movement ultrasonic detection terminal equipment | |
| US20210400211A1 (en) | Multi-modal mobile thermal imaging system | |
| KR20130113775A (en) | Acoustic probe and acoustic diagnostic system including the same | |
| AU2018266269A1 (en) | Devices, systems and methods relating to hand-held communications devices for in situ differentiation between viral and non-viral infections | |
| CN102018497A (en) | Superficial vascular display instrument | |
| CN110292373A (en) | A kind of high-performance tissue blood flow detection analytical equipment | |
| CN206081352U (en) | Intelligence laser beauty instrument | |
| CN100553554C (en) | Identification and the mammiferous dynamic thermodynamic processes and distinguish the system of this class process of classifying | |
| CN211484558U (en) | High-performance human tissue blood flow detection and analysis device | |
| CN102014215A (en) | Mobile phone with color Doppler ultrasonic scanning function | |
| CN105581785A (en) | Light path system of vein projector and vein projector | |
| CN103784165A (en) | Ultrasonic diagnosis device | |
| US20100056912A1 (en) | Method and apparatus for automatically downloading medical imaging data | |
| CN107809956A (en) | Ultrasonic device and its operating method | |
| US20230146520A1 (en) | Dual mode three-dimensional breast imaging device and method | |
| CN203252666U (en) | Ultrasonic image diagnosis device and ultrasonic probe | |
| CN109222859A (en) | A kind of intelligent endoscope image system with AI auxiliary diagnosis function | |
| CN209252833U (en) | The detection device of fusion tactile sensing and optical tomograph imaging | |
| CN202015163U (en) | Superficial blood vessel indicator |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |