CN104887216A - Multi-light-beam coherent human body skin perfusion imaging system and method - Google Patents
Multi-light-beam coherent human body skin perfusion imaging system and method Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0265—Measuring blood flow using electromagnetic means, e.g. electromagnetic flowmeter
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- A61B5/0064—Body surface scanning
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Abstract
The invention relates to a multi-light-beam coherent human body skin perfusion imaging system and a multi-light-beam coherent human body skin perfusion imaging method, and belongs to the field of clinical diagnosis. The imaging system is composed of a laser, a light-way divider, a single-mode fiber, a high-speed camera, an optical fiber, a computer and the like. By utilizing a scattering function of coherent light spread in human tissue, through a scattering characteristic, multi-light-beam coherent lighting improves coherent light, of special fibers, and through combination with advantages of traditional laser speckle contrast imaging and laser Doppler blood flow monitoring technologies, accurate body surface perfusion imaging of a human body is obtained. The method can obtain the imaging depth consistent with the imaging depth of laser Doppler blood flow monitoring, and can also achieve high temporal-spatial resolution consistent with temporal-spatial resolution of the laser speckle contrast imaging.
Description
Technical field
The present invention relates to the skin perfusion imaging technique of a kind of noinvasive, Real-Time Monitoring tissue blood flow, be specifically related to a kind of multiple beam and be concerned with human body skin Perfusion Image System and method, belong to clinical tissue blood flow imaging field.
Background technology
Early stage in nineteen sixty, the inventor of laser and first use laser person to find, when slightly being made a list in face in laser irradiation, the granular speckle that some are random can be formed.At first they claim this effect for " granule ", are referred to as afterwards " speckle ".Namely speckle when on the body surface that laser is radiated at relative coarseness (comparing with the wavelength of light), mutually interferes between the scattered light of different light path, forms Random pattern.
When by the region of illuminated with laser light through CCD imaging system, produce graininess or speckle shape Speckle on Image Plane.If scattering medium is in motion, each pixel in image will produce time dependent speckle pattern.This pattern Strength Changes over time and space contains the movable information of scattering medium.By analyzing speckle intensity change in time (as Laser Doppler Velocimeter), or the spatial statistics characteristic (as laser speckle contrast imaging) of Strength Changes, all can obtain quantitative flow rate information.
Laser Doppler vibration can not damaged, measure tissue microvascular blood flow velocity continuously, because wide accommodation, easy and simple to handle and be used widely.But laser doppler technique pointwise sampling can only survey blood flow rate, and imaging then needs to be equipped with scanning means etc., and spatial resolution is low.
Laser speckle contrast imaging method can obtain blood flowing speed information, its principle utilizes coherent light to be radiated on blood vessel, mutually interfered by after the erythrocyte scattering of moving in blood vessel, form the light distribution of speckle formula, by resolving the speckle blurring effect of this to be moved by the erythrocyte time domain that causes or spatial domain, the velocity information of Motion Particles can be obtained.Laser speckle contrast imaging technology just can realize higher spatial resolution and temporal resolution without the need to scanning, can live body ground, dynamically, contactlessly monitor blood vessels caliber and blood flow rate change, obtain hemodynamic multiple index, there is the plurality of advantages such as whole audience imaging, real-time, structure is simple, receive the concern of increasing neuroscience worker and medical worker.But laser speckle contrast imaging can only obtain the blood flowing speed information of skin surface, and can not obtain depth information.
Summary of the invention
Problem to be solved by this invention is in conjunction with laser Doppler principle and laser speckle contrast imaging technology, and object is to provide a kind of multiple beam and is concerned with human body skin Perfusion Image System and method, reasonable in design, method simple, relative inexpensiveness.
For achieving the above object, design of the present invention is as follows:
The light that laser instrument sends forms multiple beam coherent light by output optical fibre uniform irradiation on tested tissue surface, after the superposition of multiple beam coherent light enters tissue, just because histiocytic scattering forms the scattering pattern of random distribution in communication process.Control high speed camera by computer and carry out data acquisition, obtain rear orientation light and obtain scattering pattern.In data analysis, we are first by the means of Fourier transformation, based on the groundwater increment of the principle solving skin histology of laser-Doppler, make its imaging depth consistent with laser-Doppler blood flow detection, use contrast analysis to obtain the estimation of coherence time afterwards, make its imaging space resolution consistent with laser speckle contrast imaging.Therefore its main advantage is for can detect imaging depth, turn improves imaging resolution, can detect in real time and show in temporal resolution.
According to above-mentioned design, the present invention adopts following technical scheme:
A kind of multiple beam is concerned with human body skin Perfusion Image System, comprise laser instrument, optical branching device, single-mode fiber, high speed camera, optical filter, regulate support, computer, some described single-mode fibers are arranged on optical branching device, described laser instrument connects the single-mode fiber of optical branching device input, the single-mode fiber of the outfan of optical branching device is centered around around high speed camera camera lens equably, described optical filter is close on high speed camera camera lens, described computer is connected with laser instrument and high speed camera, control the switch of laser and the collection of image, described adjustment support one end connects high speed camera, the other end is fixed.
The wavelength of the light that described laser instrument sends is 830nm.
Described optical filter filters the light of below wavelength 800nm.
Described optical branching device is that single input 16 exports.
16 output optical fibres of described optical branching device are centered around around camera lens equably.
It is per second that the frame rate of described high speed camera reaches 10000 frames, and within the system, be operated in respectively at a high speed and low speed two patterns, its high speed is that 10,000 frames are per second, and low speed is that 200 frames are per second.
A kind of multiple beam is concerned with human body skin Perfusion Imaging method, and adopt above-mentioned multiple beam to be concerned with human body skin Perfusion Image System, image-forming step is as follows:
A. be adjusted to image position: according to imaged subject position, mobile adjustment support, makes high speed camera alignment lens skin surface; Open high speed camera by software, according to imaging region, the distance of adjustment high speed camera and skin surface, makes it be parked in the most clear position of image;
B. open laser instrument: open laser instrument by software control, make laser by optical branching device, be radiated at skin surface by 16 single-mode fibers, form coherent light;
C. image acquisition: image acquisition rates is divided at a high speed, i.e. 10,000 frames per second and low speed, i.e. 200 frames per second, and the two switched mutually every 1 second;
D. image procossing: for 10,000 images under high speed, to each pixel
i(x, y, t) asks fast Fourier transform, applies following formula simultaneously and obtains hematocrite concentration in tissue
cwith perfused tissue amount
pinformation:
Wherein,
a,bfor constant coefficient,
ffor frequency,
s (f)for power spectrum;
For the image of 200 under low speed, utilize speckle contrast algorithm to try to achieve and contrast angle value
k,
Wherein,
for the standard deviation of Speckle Intensity in image,
for the average of Speckle Intensity in image,
According to following formula, pass through
kvalue and time of exposure
ttry to achieve correlation time
,
，
Wherein
for constant coefficient.Final acquisition blood flow rate
v:
Wherein
cfor constant coefficient.
Compared with prior art, the present invention has following outstanding substantive distinguishing features and significant progress:
A skin perfusion imaging system for non-invasive monitoring tissue blood flow of the present invention, by low-yield coherent laser beam, generates the blood perfusion amount pcolor picture of monitored area, reasonable in design, method simple, relative inexpensiveness.Native system and method can be used for monitoring microcirculation situation that is healthy or illing tissue, also can be used for studying the microcirculation reaction under different physiological stimulation.Observation process is contactless, and application widely, comprises burn assessment, plastic surgery, wound healing and Dermatology etc.
Accompanying drawing explanation
Fig. 1 is that multiple beam of the present invention is concerned with human body skin Perfusion Image System structure chart.
Fig. 2 is product design of the present invention and application drawing.
Detailed description of the invention
Below in conjunction with accompanying drawing, enforcement of the present invention is described further.
As illustrated in fig. 1 and 2, a kind of multiple beam is concerned with human body skin Perfusion Image System, comprise laser instrument, optical branching device, single-mode fiber, high speed camera, optical filter, regulate support, computer, some described single-mode fibers are arranged on optical branching device, described laser instrument connects the single-mode fiber of optical branching device input, the single-mode fiber of the outfan of optical branching device is centered around around high speed camera camera lens equably, described optical filter is close on high speed camera camera lens, described computer is connected with laser instrument and high speed camera, control the switch of laser and the collection of image, described adjustment support one end connects high speed camera, the other end is fixed.
The wavelength of the light that described laser instrument sends is 830nm.
Described optical filter filters the light of below wavelength 800nm.
Described optical branching device is that single input 16 exports.
16 output optical fibres of described optical branching device are centered around around camera lens equably.
It is per second that the frame rate of described high speed camera reaches 10000 frames, and within the system, be operated in respectively at a high speed and low speed two patterns, its high speed is that 10,000 frames are per second, and low speed is that 200 frames are per second.
A kind of multiple beam is concerned with human body skin Perfusion Imaging method, and adopt above-mentioned multiple beam to be concerned with human body skin Perfusion Image System, image-forming step is as follows:
A. be adjusted to image position: according to imaged subject position, mobile adjustment support, makes high speed camera alignment lens skin surface; Open high speed camera by software, according to imaging region, the distance of adjustment high speed camera and skin surface, makes it be parked in the most clear position of image;
B. open laser instrument: open laser instrument by software control, make laser by optical branching device, be radiated at skin surface by 16 single-mode fibers, form coherent light;
C. image acquisition: image acquisition rates is divided at a high speed, i.e. 10,000 frames per second and low speed, i.e. 200 frames per second, and the two switched mutually every 1 second;
D. image procossing: for 10,000 images under high speed, to each pixel
i(x, y, t) asks fast Fourier transform, applies following formula simultaneously and obtains hematocrite concentration in tissue
cwith perfused tissue amount
pinformation:
Wherein,
a,bfor constant coefficient,
ffor frequency,
s (f)for power spectrum;
For the image of 200 under low speed, utilize speckle contrast algorithm to try to achieve and contrast angle value
k,
Wherein,
for the standard deviation of Speckle Intensity in image,
for the average of Speckle Intensity in image,
According to following formula, pass through
kvalue and time of exposure
ttry to achieve correlation time
,
，
Wherein
for constant coefficient.Final acquisition blood flow rate
v:
Wherein
cfor constant coefficient.
The be concerned with central principle of human body skin Perfusion Image System of multiple beam is the scattering process utilizing coherent light to propagate in tissue, in conjunction with the advantage of traditional laser speckle contrast imaging and laser-Doppler blood flow monitoring technology, first by the multiple beam coherent illumination of special optical fiber, improve the characteristic of coherent light, then data acquisition is carried out by high speed camera, when being carried out by computer more simultaneously-and frequency signal analysis, finally obtain body surface Perfusion Imaging accurately.
Claims (7)
1. a multiple beam is concerned with human body skin Perfusion Image System, it is characterized in that, comprise laser instrument, optical branching device, single-mode fiber, high speed camera, optical filter, regulate support, computer, some described single-mode fibers are arranged on optical branching device, described laser instrument connects the single-mode fiber of optical branching device input, the single-mode fiber of the outfan of optical branching device is centered around around high speed camera camera lens equably, described optical filter is close on high speed camera camera lens, described computer is connected with laser instrument and high speed camera, control the switch of laser and the collection of image, described adjustment support one end connects high speed camera, the other end is fixed.
2. multiple beam according to claim 1 is concerned with human body skin Perfusion Image System, and it is characterized in that, the wavelength of the light that described laser instrument sends is 830nm.
3. multiple beam according to claim 1 is concerned with human body skin Perfusion Image System, and it is characterized in that, described optical filter filters the light of below wavelength 800nm.
4. multiple beam according to claim 1 is concerned with human body skin Perfusion Image System, and it is characterized in that, described optical branching device is that single input 16 exports.
5. multiple beam according to claim 1 is concerned with human body skin Perfusion Image System, and it is characterized in that, 16 output optical fibres of described optical branching device are centered around around camera lens equably.
6. multiple beam according to claim 1 is concerned with human body skin Perfusion Image System, it is characterized in that, it is per second that the frame rate of described high speed camera reaches 10000 frames, and within the system, be operated in high speed and low speed two patterns respectively, its high speed is that 10,000 frames are per second, and low speed is that 200 frames are per second.
7. multiple beam is concerned with a human body skin Perfusion Imaging method, and adopt multiple beam according to claim 1 to be concerned with human body skin Perfusion Image System, it is characterized in that, image-forming step is as follows:
A. be adjusted to image position: according to imaged subject position, mobile adjustment support, makes high speed camera alignment lens skin surface; Open high speed camera by software, according to imaging region, the distance of adjustment high speed camera and skin surface, makes it be parked in the most clear position of image;
B. open laser instrument: open laser instrument by software control, make laser by optical branching device, be radiated at skin surface by 16 single-mode fibers, form coherent light;
C. image acquisition: image acquisition rates is divided at a high speed, i.e. 10,000 frames per second and low speed, i.e. 200 frames per second, and the two switched mutually every 1 second;
D. image procossing: for 10,000 images under high speed, to each pixel
i(x, y, t) asks fast Fourier transform, applies following formula simultaneously and obtains hematocrite concentration in tissue
cwith perfused tissue amount
pinformation:
Wherein,
a,bfor constant coefficient,
ffor frequency,
s (f)for power spectrum;
For the image of 200 under low speed, utilize speckle contrast algorithm to try to achieve and contrast angle value
k,
Wherein,
for the standard deviation of Speckle Intensity in image,
for the average of Speckle Intensity in image,
According to following formula, pass through
kvalue and time of exposure
ttry to achieve correlation time
,
Wherein
for constant coefficient, finally obtain blood flow rate
v:
Wherein
cfor constant coefficient.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107485383A (en) * | 2017-09-29 | 2017-12-19 | 佛山科学技术学院 | A kind of speckle blood flow imaging method and apparatus based on constituent analysis |
| CN109222952A (en) * | 2018-07-17 | 2019-01-18 | 上海健康医学院 | A kind of laser speckle perfusion weighted imaging method |
| CN110292373A (en) * | 2019-07-23 | 2019-10-01 | 优谱激光科技(南京)有限公司 | A kind of high-performance tissue blood flow detection analytical equipment |
| CN111833314A (en) * | 2020-06-22 | 2020-10-27 | 中国科学院西安光学精密机械研究所 | Skin blood perfusion non-contact monitoring method and monitoring system under motion state |
| CN112998683A (en) * | 2021-02-23 | 2021-06-22 | 上海川义医疗器械有限公司 | System and method for detecting upper limb lymphedema of breast cancer after operation based on multi-mode optical imaging technology |
| CN113063755A (en) * | 2015-11-17 | 2021-07-02 | 韩国科学技术院 | Sample characteristic detection device using chaotic wave sensor |
| CN113974574A (en) * | 2021-12-15 | 2022-01-28 | 潍坊医学院 | Imaging system and imaging method based on multi-modal optics |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113063755A (en) * | 2015-11-17 | 2021-07-02 | 韩国科学技术院 | Sample characteristic detection device using chaotic wave sensor |
| CN107485383A (en) * | 2017-09-29 | 2017-12-19 | 佛山科学技术学院 | A kind of speckle blood flow imaging method and apparatus based on constituent analysis |
| CN109222952A (en) * | 2018-07-17 | 2019-01-18 | 上海健康医学院 | A kind of laser speckle perfusion weighted imaging method |
| CN110292373A (en) * | 2019-07-23 | 2019-10-01 | 优谱激光科技(南京)有限公司 | A kind of high-performance tissue blood flow detection analytical equipment |
| CN111833314A (en) * | 2020-06-22 | 2020-10-27 | 中国科学院西安光学精密机械研究所 | Skin blood perfusion non-contact monitoring method and monitoring system under motion state |
| CN111833314B (en) * | 2020-06-22 | 2023-09-01 | 中国科学院西安光学精密机械研究所 | Non-contact monitoring method and monitoring system for skin blood perfusion under motion state |
| CN112998683A (en) * | 2021-02-23 | 2021-06-22 | 上海川义医疗器械有限公司 | System and method for detecting upper limb lymphedema of breast cancer after operation based on multi-mode optical imaging technology |
| CN112998683B (en) * | 2021-02-23 | 2024-02-20 | 上海川义医疗器械有限公司 | System and method for detecting upper limb lymphedema after breast cancer operation based on multi-mode optical imaging technology |
| CN113974574A (en) * | 2021-12-15 | 2022-01-28 | 潍坊医学院 | Imaging system and imaging method based on multi-modal optics |
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