CN110290834A - With epidermis electronic monitoring and treatment pain - Google Patents
With epidermis electronic monitoring and treatment pain Download PDFInfo
- Publication number
- CN110290834A CN110290834A CN201780084773.4A CN201780084773A CN110290834A CN 110290834 A CN110290834 A CN 110290834A CN 201780084773 A CN201780084773 A CN 201780084773A CN 110290834 A CN110290834 A CN 110290834A
- Authority
- CN
- China
- Prior art keywords
- sensor
- physical feeling
- pain
- processor
- movement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000002193 Pain Diseases 0.000 title claims abstract description 254
- 230000036407 pain Effects 0.000 title claims abstract description 245
- 210000002615 epidermis Anatomy 0.000 title claims description 243
- 238000011282 treatment Methods 0.000 title claims description 73
- 238000012544 monitoring process Methods 0.000 title abstract description 24
- 230000033001 locomotion Effects 0.000 claims abstract description 447
- 239000012636 effector Substances 0.000 claims abstract description 115
- 239000000758 substrate Substances 0.000 claims abstract description 99
- 238000000034 method Methods 0.000 claims abstract description 88
- 238000001514 detection method Methods 0.000 claims abstract description 62
- 238000004891 communication Methods 0.000 claims description 130
- 238000005259 measurement Methods 0.000 claims description 100
- 210000003491 skin Anatomy 0.000 claims description 71
- 230000000694 effects Effects 0.000 claims description 63
- 210000003205 muscle Anatomy 0.000 claims description 47
- 230000004913 activation Effects 0.000 claims description 40
- 230000004044 response Effects 0.000 claims description 38
- 239000000126 substance Substances 0.000 claims description 32
- 210000000707 wrist Anatomy 0.000 claims description 29
- 230000035479 physiological effects, processes and functions Effects 0.000 claims description 25
- 206010003246 arthritis Diseases 0.000 claims description 20
- 230000005540 biological transmission Effects 0.000 claims description 19
- 230000000638 stimulation Effects 0.000 claims description 19
- 210000003423 ankle Anatomy 0.000 claims description 18
- 230000000284 resting effect Effects 0.000 claims description 16
- 238000002604 ultrasonography Methods 0.000 claims description 14
- 239000000700 radioactive tracer Substances 0.000 claims description 13
- 239000012491 analyte Substances 0.000 claims description 11
- 210000000746 body region Anatomy 0.000 claims description 11
- 229920000642 polymer Polymers 0.000 claims description 11
- 210000004243 sweat Anatomy 0.000 claims description 10
- 208000000112 Myalgia Diseases 0.000 claims description 9
- 208000027418 Wounds and injury Diseases 0.000 claims description 9
- 210000002414 leg Anatomy 0.000 claims description 9
- 230000001537 neural effect Effects 0.000 claims description 9
- 208000004296 neuralgia Diseases 0.000 claims description 8
- 206010052428 Wound Diseases 0.000 claims description 7
- 208000006820 Arthralgia Diseases 0.000 claims description 6
- 210000002832 shoulder Anatomy 0.000 claims description 6
- 206010019233 Headaches Diseases 0.000 claims description 5
- 210000002683 foot Anatomy 0.000 claims description 5
- 210000003127 knee Anatomy 0.000 claims description 5
- 210000003371 toe Anatomy 0.000 claims description 5
- 206010043255 Tendonitis Diseases 0.000 claims description 4
- 229920001971 elastomer Polymers 0.000 claims description 4
- 231100000869 headache Toxicity 0.000 claims description 4
- 230000003213 activating effect Effects 0.000 claims description 3
- 210000001217 buttock Anatomy 0.000 claims description 3
- 239000000806 elastomer Substances 0.000 claims description 3
- 208000020947 enthesitis Diseases 0.000 claims description 3
- 239000000416 hydrocolloid Substances 0.000 claims description 3
- 230000026683 transduction Effects 0.000 claims description 3
- 238000010361 transduction Methods 0.000 claims description 3
- 208000001640 Fibromyalgia Diseases 0.000 claims description 2
- 201000002481 Myositis Diseases 0.000 claims description 2
- 230000037326 chronic stress Effects 0.000 claims description 2
- 206010029240 Neuritis Diseases 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 210000002808 connective tissue Anatomy 0.000 claims 1
- 238000002565 electrocardiography Methods 0.000 claims 1
- 210000004126 nerve fiber Anatomy 0.000 claims 1
- 238000012545 processing Methods 0.000 description 100
- 230000001133 acceleration Effects 0.000 description 90
- 230000006378 damage Effects 0.000 description 71
- 230000002452 interceptive effect Effects 0.000 description 55
- 239000000463 material Substances 0.000 description 48
- 230000035882 stress Effects 0.000 description 48
- 230000006870 function Effects 0.000 description 44
- 230000015654 memory Effects 0.000 description 42
- 210000005036 nerve Anatomy 0.000 description 41
- 230000003287 optical effect Effects 0.000 description 34
- 230000004888 barrier function Effects 0.000 description 33
- 230000005611 electricity Effects 0.000 description 33
- 230000008859 change Effects 0.000 description 28
- 238000010586 diagram Methods 0.000 description 27
- 239000000835 fiber Substances 0.000 description 25
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 24
- 230000003993 interaction Effects 0.000 description 23
- 238000003860 storage Methods 0.000 description 23
- 229910052710 silicon Inorganic materials 0.000 description 22
- 239000010703 silicon Substances 0.000 description 22
- 230000036544 posture Effects 0.000 description 18
- 238000004422 calculation algorithm Methods 0.000 description 17
- 238000005452 bending Methods 0.000 description 16
- 230000007830 nerve conduction Effects 0.000 description 16
- 239000003814 drug Substances 0.000 description 14
- 238000005516 engineering process Methods 0.000 description 14
- 238000002560 therapeutic procedure Methods 0.000 description 14
- 210000001519 tissue Anatomy 0.000 description 14
- 239000011469 building brick Substances 0.000 description 13
- 239000004744 fabric Substances 0.000 description 13
- 229910052751 metal Inorganic materials 0.000 description 13
- 239000002184 metal Substances 0.000 description 13
- 230000007246 mechanism Effects 0.000 description 12
- 230000001684 chronic effect Effects 0.000 description 11
- 238000004590 computer program Methods 0.000 description 11
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 10
- 230000008901 benefit Effects 0.000 description 10
- 239000008103 glucose Substances 0.000 description 10
- 239000004020 conductor Substances 0.000 description 9
- 230000006698 induction Effects 0.000 description 9
- 208000001294 Nociceptive Pain Diseases 0.000 description 8
- 238000013459 approach Methods 0.000 description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 230000007774 longterm Effects 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 239000007769 metal material Substances 0.000 description 8
- 229910052760 oxygen Inorganic materials 0.000 description 8
- 239000001301 oxygen Substances 0.000 description 8
- ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 description 7
- 241000208340 Araliaceae Species 0.000 description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 7
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 7
- 235000003140 Panax quinquefolius Nutrition 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 7
- 238000000576 coating method Methods 0.000 description 7
- 210000003414 extremity Anatomy 0.000 description 7
- 235000008434 ginseng Nutrition 0.000 description 7
- 239000010931 gold Substances 0.000 description 7
- 238000003384 imaging method Methods 0.000 description 7
- 230000001965 increasing effect Effects 0.000 description 7
- 230000004048 modification Effects 0.000 description 7
- 238000012986 modification Methods 0.000 description 7
- -1 polyethylene Polymers 0.000 description 7
- 239000004065 semiconductor Substances 0.000 description 7
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 6
- 208000005298 acute pain Diseases 0.000 description 6
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 6
- 210000000988 bone and bone Anatomy 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 210000003128 head Anatomy 0.000 description 6
- 230000003387 muscular Effects 0.000 description 6
- 239000002121 nanofiber Substances 0.000 description 6
- 230000008685 targeting Effects 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 241000209094 Oryza Species 0.000 description 5
- 235000007164 Oryza sativa Nutrition 0.000 description 5
- 229910021607 Silver chloride Inorganic materials 0.000 description 5
- 208000005392 Spasm Diseases 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000003792 electrolyte Substances 0.000 description 5
- 229910021389 graphene Inorganic materials 0.000 description 5
- 230000009931 harmful effect Effects 0.000 description 5
- 229940088597 hormone Drugs 0.000 description 5
- 239000005556 hormone Substances 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 208000021722 neuropathic pain Diseases 0.000 description 5
- 210000000929 nociceptor Anatomy 0.000 description 5
- 230000002441 reversible effect Effects 0.000 description 5
- 235000009566 rice Nutrition 0.000 description 5
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 5
- 230000000007 visual effect Effects 0.000 description 5
- 101800004538 Bradykinin Proteins 0.000 description 4
- 102400000967 Bradykinin Human genes 0.000 description 4
- 206010011985 Decubitus ulcer Diseases 0.000 description 4
- 206010017577 Gait disturbance Diseases 0.000 description 4
- 108010015776 Glucose oxidase Proteins 0.000 description 4
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 206010033664 Panic attack Diseases 0.000 description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
- 208000004210 Pressure Ulcer Diseases 0.000 description 4
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 4
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 4
- 208000003443 Unconsciousness Diseases 0.000 description 4
- 230000001154 acute effect Effects 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 4
- 230000001070 adhesive effect Effects 0.000 description 4
- 230000009910 autonomic response Effects 0.000 description 4
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 description 4
- 210000000038 chest Anatomy 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 210000003195 fascia Anatomy 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 210000000245 forearm Anatomy 0.000 description 4
- 230000005021 gait Effects 0.000 description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 4
- 229910052737 gold Inorganic materials 0.000 description 4
- 230000005484 gravity Effects 0.000 description 4
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 4
- 230000002757 inflammatory effect Effects 0.000 description 4
- 238000007689 inspection Methods 0.000 description 4
- 230000000302 ischemic effect Effects 0.000 description 4
- 238000003475 lamination Methods 0.000 description 4
- 230000001404 mediated effect Effects 0.000 description 4
- 239000002127 nanobelt Substances 0.000 description 4
- 210000003739 neck Anatomy 0.000 description 4
- 108091008700 nociceptors Proteins 0.000 description 4
- 238000011017 operating method Methods 0.000 description 4
- 208000019906 panic disease Diseases 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 239000011591 potassium Substances 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 210000002435 tendon Anatomy 0.000 description 4
- 239000010936 titanium Substances 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 208000000003 Breakthrough pain Diseases 0.000 description 3
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 description 3
- 102000004414 Calcitonin Gene-Related Peptide Human genes 0.000 description 3
- 208000000094 Chronic Pain Diseases 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 3
- 239000004366 Glucose oxidase Substances 0.000 description 3
- 206010029216 Nervousness Diseases 0.000 description 3
- 201000001263 Psoriatic Arthritis Diseases 0.000 description 3
- 208000036824 Psoriatic arthropathy Diseases 0.000 description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 3
- 206010044565 Tremor Diseases 0.000 description 3
- 210000000467 autonomic pathway Anatomy 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 230000036772 blood pressure Effects 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 230000008602 contraction Effects 0.000 description 3
- 238000000151 deposition Methods 0.000 description 3
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000006073 displacement reaction Methods 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 210000001097 facial muscle Anatomy 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 229940116332 glucose oxidase Drugs 0.000 description 3
- 235000019420 glucose oxidase Nutrition 0.000 description 3
- 210000004209 hair Anatomy 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- 229910052451 lead zirconate titanate Inorganic materials 0.000 description 3
- 210000003041 ligament Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000004118 muscle contraction Effects 0.000 description 3
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 3
- 239000013307 optical fiber Substances 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 230000008520 organization Effects 0.000 description 3
- 201000008482 osteoarthritis Diseases 0.000 description 3
- 238000002496 oximetry Methods 0.000 description 3
- 238000002638 palliative care Methods 0.000 description 3
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 230000000770 proinflammatory effect Effects 0.000 description 3
- 230000001107 psychogenic effect Effects 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 230000000241 respiratory effect Effects 0.000 description 3
- 230000029058 respiratory gaseous exchange Effects 0.000 description 3
- 206010039073 rheumatoid arthritis Diseases 0.000 description 3
- 229920005573 silicon-containing polymer Polymers 0.000 description 3
- 230000007958 sleep Effects 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- 230000008093 supporting effect Effects 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- 239000004753 textile Substances 0.000 description 3
- 229910052719 titanium Inorganic materials 0.000 description 3
- 230000000472 traumatic effect Effects 0.000 description 3
- 239000013598 vector Substances 0.000 description 3
- 238000004804 winding Methods 0.000 description 3
- 108091023037 Aptamer Proteins 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 102400000739 Corticotropin Human genes 0.000 description 2
- 101800000414 Corticotropin Proteins 0.000 description 2
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 2
- 206010016059 Facial pain Diseases 0.000 description 2
- 206010061991 Grimacing Diseases 0.000 description 2
- 208000004454 Hyperalgesia Diseases 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 241001062009 Indigofera Species 0.000 description 2
- 102000004125 Interleukin-1alpha Human genes 0.000 description 2
- 108010082786 Interleukin-1alpha Proteins 0.000 description 2
- 108090001005 Interleukin-6 Proteins 0.000 description 2
- 108090001007 Interleukin-8 Proteins 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- 108010073450 Lactate 2-monooxygenase Proteins 0.000 description 2
- 101800003845 Neuropeptide Y Proteins 0.000 description 2
- 102400000064 Neuropeptide Y Human genes 0.000 description 2
- 108090000189 Neuropeptides Proteins 0.000 description 2
- 102000003797 Neuropeptides Human genes 0.000 description 2
- 208000000114 Pain Threshold Diseases 0.000 description 2
- ORNBQBCIOKFOEO-YQUGOWONSA-N Pregnenolone Natural products O=C(C)[C@@H]1[C@@]2(C)[C@H]([C@H]3[C@@H]([C@]4(C)C(=CC3)C[C@@H](O)CC4)CC2)CC1 ORNBQBCIOKFOEO-YQUGOWONSA-N 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 208000031074 Reinjury Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 208000013200 Stress disease Diseases 0.000 description 2
- 208000004760 Tenosynovitis Diseases 0.000 description 2
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000004411 aluminium Substances 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 230000002917 arthritic effect Effects 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 239000003990 capacitor Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 230000010485 coping Effects 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 2
- 229960000258 corticotropin Drugs 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- FMGSKLZLMKYGDP-USOAJAOKSA-N dehydroepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 FMGSKLZLMKYGDP-USOAJAOKSA-N 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 2
- 229960002986 dinoprostone Drugs 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 210000000624 ear auricle Anatomy 0.000 description 2
- 238000002567 electromyography Methods 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 230000005669 field effect Effects 0.000 description 2
- 229930195712 glutamate Natural products 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 210000001624 hip Anatomy 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 229960000890 hydrocortisone Drugs 0.000 description 2
- 230000000917 hyperalgesic effect Effects 0.000 description 2
- 208000018875 hypoxemia Diseases 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- HFGPZNIAWCZYJU-UHFFFAOYSA-N lead zirconate titanate Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ti+4].[Zr+4].[Pb+2] HFGPZNIAWCZYJU-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000004973 liquid crystal related substance Substances 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 230000005055 memory storage Effects 0.000 description 2
- 229910044991 metal oxide Inorganic materials 0.000 description 2
- 238000010295 mobile communication Methods 0.000 description 2
- 208000019382 nerve compression syndrome Diseases 0.000 description 2
- 210000001640 nerve ending Anatomy 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 230000005693 optoelectronics Effects 0.000 description 2
- 238000006213 oxygenation reaction Methods 0.000 description 2
- 230000037040 pain threshold Effects 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 238000005424 photoluminescence Methods 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 229920000301 poly(3-hexylthiophene-2,5-diyl) polymer Polymers 0.000 description 2
- 229920000052 poly(p-xylylene) Polymers 0.000 description 2
- 229920002037 poly(vinyl butyral) polymer Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 229960000249 pregnenolone Drugs 0.000 description 2
- ORNBQBCIOKFOEO-QGVNFLHTSA-N pregnenolone Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 ORNBQBCIOKFOEO-QGVNFLHTSA-N 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 229960003387 progesterone Drugs 0.000 description 2
- 239000000186 progesterone Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000011321 prophylaxis Methods 0.000 description 2
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 2
- 150000003180 prostaglandins Chemical class 0.000 description 2
- XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 description 2
- 238000002106 pulse oximetry Methods 0.000 description 2
- 229940107700 pyruvic acid Drugs 0.000 description 2
- 230000011514 reflex Effects 0.000 description 2
- 238000004153 renaturation Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000000392 somatic effect Effects 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- ADNPLDHMAVUMIW-CUZNLEPHSA-N substance P Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 ADNPLDHMAVUMIW-CUZNLEPHSA-N 0.000 description 2
- 229960003604 testosterone Drugs 0.000 description 2
- 210000000115 thoracic cavity Anatomy 0.000 description 2
- 108010050939 thrombocytin Proteins 0.000 description 2
- 229940034208 thyroxine Drugs 0.000 description 2
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 2
- 208000009935 visceral pain Diseases 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- RPAJSBKBKSSMLJ-DFWYDOINSA-N (2s)-2-aminopentanedioic acid;hydrochloride Chemical compound Cl.OC(=O)[C@@H](N)CCC(O)=O RPAJSBKBKSSMLJ-DFWYDOINSA-N 0.000 description 1
- GKWLILHTTGWKLQ-UHFFFAOYSA-N 2,3-dihydrothieno[3,4-b][1,4]dioxine Chemical compound O1CCOC2=CSC=C21 GKWLILHTTGWKLQ-UHFFFAOYSA-N 0.000 description 1
- LLLVZDVNHNWSDS-UHFFFAOYSA-N 4-methylidene-3,5-dioxabicyclo[5.2.2]undeca-1(9),7,10-triene-2,6-dione Chemical compound C1(C2=CC=C(C(=O)OC(=C)O1)C=C2)=O LLLVZDVNHNWSDS-UHFFFAOYSA-N 0.000 description 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 108060001064 Calcitonin Proteins 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 206010009696 Clumsiness Diseases 0.000 description 1
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229910001218 Gallium arsenide Inorganic materials 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 229910052689 Holmium Inorganic materials 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 208000003456 Juvenile Arthritis Diseases 0.000 description 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 description 1
- 206010054949 Metaplasia Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108010061951 Methemoglobin Proteins 0.000 description 1
- 102000002151 Microfilament Proteins Human genes 0.000 description 1
- 108010040897 Microfilament Proteins Proteins 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 208000016285 Movement disease Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 208000029549 Muscle injury Diseases 0.000 description 1
- 229920000557 Nafion® Polymers 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 206010039203 Road traffic accident Diseases 0.000 description 1
- 239000002042 Silver nanowire Substances 0.000 description 1
- 206010058907 Spinal deformity Diseases 0.000 description 1
- 241000254223 Syntexis Species 0.000 description 1
- 208000000491 Tendinopathy Diseases 0.000 description 1
- 206010043269 Tension headache Diseases 0.000 description 1
- 208000008548 Tension-Type Headache Diseases 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- MCEWYIDBDVPMES-UHFFFAOYSA-N [60]pcbm Chemical compound C123C(C4=C5C6=C7C8=C9C%10=C%11C%12=C%13C%14=C%15C%16=C%17C%18=C(C=%19C=%20C%18=C%18C%16=C%13C%13=C%11C9=C9C7=C(C=%20C9=C%13%18)C(C7=%19)=C96)C6=C%11C%17=C%15C%13=C%15C%14=C%12C%12=C%10C%10=C85)=C9C7=C6C2=C%11C%13=C2C%15=C%12C%10=C4C23C1(CCCC(=O)OC)C1=CC=CC=C1 MCEWYIDBDVPMES-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 206010053552 allodynia Diseases 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 238000004082 amperometric method Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000037147 athletic performance Effects 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 230000002567 autonomic effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000009954 braiding Methods 0.000 description 1
- 230000007177 brain activity Effects 0.000 description 1
- PWLNAUNEAKQYLH-UHFFFAOYSA-N butyric acid octyl ester Natural products CCCCCCCCOC(=O)CCC PWLNAUNEAKQYLH-UHFFFAOYSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 208000003295 carpal tunnel syndrome Diseases 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000002322 conducting polymer Substances 0.000 description 1
- 229920001940 conductive polymer Polymers 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000005034 decoration Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- KVEAILYLMGOETO-UHFFFAOYSA-H dicalcium magnesium diphosphate Chemical compound P(=O)([O-])([O-])[O-].[Mg+2].[Ca+2].[Ca+2].P(=O)([O-])([O-])[O-] KVEAILYLMGOETO-UHFFFAOYSA-H 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000005518 electrochemistry Effects 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 230000005662 electromechanics Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 210000003811 finger Anatomy 0.000 description 1
- 230000005057 finger movement Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 239000003574 free electron Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 210000005003 heart tissue Anatomy 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- KJZYNXUDTRRSPN-UHFFFAOYSA-N holmium atom Chemical compound [Ho] KJZYNXUDTRRSPN-UHFFFAOYSA-N 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 210000003692 ilium Anatomy 0.000 description 1
- 150000002466 imines Chemical class 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- AMGQUBHHOARCQH-UHFFFAOYSA-N indium;oxotin Chemical compound [In].[Sn]=O AMGQUBHHOARCQH-UHFFFAOYSA-N 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229920000592 inorganic polymer Polymers 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 description 1
- 238000009940 knitting Methods 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000010338 mechanical breakdown Methods 0.000 description 1
- 210000001617 median nerve Anatomy 0.000 description 1
- 208000032184 meralgia paresthetica Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000015689 metaplastic ossification Effects 0.000 description 1
- 210000003632 microfilament Anatomy 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 229910021421 monocrystalline silicon Inorganic materials 0.000 description 1
- 210000000663 muscle cell Anatomy 0.000 description 1
- 210000001087 myotubule Anatomy 0.000 description 1
- UUIQMZJEGPQKFD-UHFFFAOYSA-N n-butyric acid methyl ester Natural products CCCC(=O)OC UUIQMZJEGPQKFD-UHFFFAOYSA-N 0.000 description 1
- 239000002070 nanowire Substances 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 230000007383 nerve stimulation Effects 0.000 description 1
- 230000006855 networking Effects 0.000 description 1
- 230000002981 neuropathic effect Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N o-dimethylbenzene Natural products CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000008058 pain sensation Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 238000001259 photo etching Methods 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000767 polyaniline Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 210000002442 prefrontal cortex Anatomy 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 108091008706 proprioceptors Proteins 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 238000013441 quality evaluation Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 208000012802 recumbency Diseases 0.000 description 1
- 208000000029 referred pain Diseases 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000036387 respiratory rate Effects 0.000 description 1
- 230000026416 response to pain Effects 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 230000020341 sensory perception of pain Effects 0.000 description 1
- SDLBJIZEEMKQKY-UHFFFAOYSA-M silver chlorate Chemical compound [Ag+].[O-]Cl(=O)=O SDLBJIZEEMKQKY-UHFFFAOYSA-M 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 230000008326 skin blood flow Effects 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 201000004415 tendinitis Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000000287 tissue oxygenation Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000001515 vagal effect Effects 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0622—Optical stimulation for exciting neural tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4824—Touch or pain perception evaluation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6832—Means for maintaining contact with the body using adhesives
- A61B5/6833—Adhesive patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7271—Specific aspects of physiological measurement analysis
- A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7271—Specific aspects of physiological measurement analysis
- A61B5/7282—Event detection, e.g. detecting unique waveforms indicative of a medical condition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0625—Warming the body, e.g. hyperthermia treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
- A61B2562/0214—Capacitive electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0219—Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/06—Arrangements of multiple sensors of different types
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
- A61B2562/164—Details of sensor housings or probes; Details of structural supports for sensors the sensor is mounted in or on a conformable substrate or carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
- A61B5/0022—Monitoring a patient using a global network, e.g. telephone networks, internet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/02405—Determining heart rate variability
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/02416—Detecting, measuring or recording pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/0816—Measuring devices for examining respiratory frequency
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
- A61B5/1121—Determining geometric values, e.g. centre of rotation or angular range of movement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/389—Electromyography [EMG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0492—Patch electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36003—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of motor muscles, e.g. for walking assistance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0626—Monitoring, verifying, controlling systems and methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
Abstract
Describe the system and method for the pain status for monitoring, treating and preventing individual.On the one hand, a kind of system includes but is not limited to: deformable substrate;Sensor module, it is coupled to the deformable substrate, the sensor module includes motion sensor and biosensor, and the sensor module is configured as generating one or more sensing signals to the detection of the physiological parameter of the physical feeling to the detection of the movements of parts of the body and by the biosensor based on by the motion sensor;Processor comprising be configured as identifying the circuit of the physiological status of the individual subjects based at least one of the movement of the physical feeling or described physiological parameter;And effector, the processor can be operatively coupled to and be configured to respond to the control of the processor and influence the physical feeling.
Description
All themes of priority application are incorporated herein by reference in the case where these themes are not inconsistent with this paper.
Summary of the invention
On the one hand, a kind of pain therapy equipment includes but is not limited to: deformable substrate is configured to tested with individual
The skin surface of the physical feeling of person engages;Sensor module is coupled to the deformable substrate, the sensor module packet
Motion sensor and biosensor are included, the sensor module is configured as being based on by the motion sensor to the body
The detection of the movement at position and by the biosensor detection of the physiological parameter of the physical feeling is generated one or
Multiple sensing signals;Processor, can be operatively coupled to the sensor module and being configured as receive it is one or
Multiple sensing signals, the processor include being configured as in the movement or the physiological parameter based on the physical feeling
At least one circuit to identify at least one physiological status (including pain status) of the individual subjects;And effect
Device can be operatively coupled to the processor and be configured to respond to the processor based on the physical feeling
Control when pain status to identify the individual Z examination person of the movement or at least one of the physiological parameter and influence
The physical feeling.
In one aspect, a kind of method includes but is not limited to: via epidermis electronic equipment detection movements of parts of the body and
The physiological parameter of the physical feeling;Physiology ginseng based on the movement and the physical feeling to the physical feeling
Several detections generates one or more sensing signals;One or more of sensing signals are received with computer processor;It is based on
At least one of the movement of the physical feeling or the physiological parameter identify at least the one of the individual subjects
Kind pain status;And based at least one of the movement of the physical feeling or described physiological parameter to identify
When stating at least one pain status of individual subjects, control signal is sent with activation effect device and acts on the body
Position.
Foregoing summary is merely illustrative, and is not intended to be in any way limiting.By reference to attached drawing and connect
The detailed description got off, other than the aspect of above description, embodiment and feature, further aspect, embodiment
It also will become obvious with feature.
Detailed description of the invention
Figure 1A is the schematic diagram of an embodiment of epidermis electronic equipment, and it illustrates the individual units of the equipment.
Figure 1B is the schematic cross section of an embodiment of epidermis electronic equipment, and it illustrates the single lists of the equipment
Member.
Fig. 2A is the schematic diagram of an embodiment of epidermis electronic equipment, and which show be configured to using acceleration measuring
Measure the unit in orientation.
Fig. 2 B is the schematic diagram of an embodiment of epidermis electronic equipment, which show be configured to using inclinometer and/
Or the unit in gyroscope measurement orientation.
Fig. 2 C is the diagram configured according to the sensor of an embodiment of epidermis electronic equipment.
Fig. 3 A is the decomposition diagram of an embodiment of epidermis electronic equipment, and it illustrates more details.
Fig. 3 B is the schematic diagram of an embodiment of epidermis electronic equipment, and it illustrates the more details of electronic component.
Fig. 4 A is the schematic diagram of the another embodiment of epidermis electronic equipment.
Fig. 4 B is the signal of the electronic device layer (electronics layer) of the another embodiment of epidermis electronic equipment
Figure.
Fig. 5 is the schematic diagram of two to communicate with each other the embodiment of epidermis electronic equipment.
Fig. 6 is the signal for measuring the embodiment of the epidermis electronic equipment relative to the orientation of several physical feelings
Figure.
Fig. 7 is the flow chart that the operation of an embodiment of epidermis electronic equipment is described in detail.
Fig. 8 is the flow chart with additional detail, and it illustrates the operations of the embodiment to epidermis electronic equipment.
Fig. 9 is for monitoring, treating and preventing showing for the system of repeated stress damage, arthritis or other medical conditions
It is intended to.
Figure 10 is the schematic diagram of the embodiment of all systems as shown in Figure 9.
Figure 11 is the schematic diagram of the embodiment of all systems as shown in Figure 9.
Figure 12 is the schematic diagram of the embodiment of all systems as shown in Figure 9.
Figure 13 is the schematic diagram of the embodiment of all systems as shown in Figure 9.
Figure 14 is the schematic diagram of the embodiment of all systems as shown in Figure 9.
Figure 15 A is the schematic diagram of the embodiment of all systems as shown in Figure 9.
Figure 15 B is the schematic diagram of the embodiment of all systems as shown in Figure 9.
Figure 16 is for monitoring, treating and preventing repeated stress damage, arthritis or the system of other medical conditions
Schematic diagram.
Figure 17 is monitoring, prevents and treats medical conditions relevant to repeated stress damage, arthritis or other medicine
The flow chart of the method for illness.
Figure 18 is the flow chart for showing the various aspects of method shown in such as Figure 17.
Figure 19 is the flow chart for showing the various aspects of method shown in such as Figure 17.
Figure 20 is the flow chart for showing the various aspects of method shown in such as Figure 19.
Figure 21 is the flow chart for showing the various aspects of method shown in such as Figure 19.
Figure 22 is the flow chart for showing the various aspects of method shown in such as Figure 19.
Figure 23 is the flow chart for showing the various aspects of method shown in such as Figure 17.
Figure 24 is the flow chart for showing the various aspects of method shown in such as Figure 17.
Figure 25 is the flow chart for showing the various aspects of method shown in such as Figure 17.
Figure 26 is the flow chart for showing the various aspects of method shown in such as Figure 17.
Figure 27 is the flow chart for showing the various aspects of method shown in such as Figure 26.
Figure 28 is the flow chart for showing the various aspects of method shown in such as Figure 17.
Figure 29 is the flow chart for showing the various aspects of method shown in such as Figure 17.
Figure 30 is the flow chart for showing the various aspects of method shown in such as Figure 17.
Figure 31 is including but not limited to supervised for the schematic diagram for the system for monitoring and treating the physiological status of individual subjects
Survey and treat the pain status of individual subjects.
Figure 32 is the schematic diagram of the embodiment of system shown in such as Figure 31.
Figure 33 is the schematic diagram of the embodiment of system shown in such as Figure 31.
Figure 34 is the schematic diagram of the embodiment of system shown in such as Figure 31.
Figure 35 is the schematic diagram of the embodiment of system shown in such as Figure 31.
Figure 36 is the schematic diagram of the embodiment of system shown in such as Figure 31.
Specific embodiment
Attached drawing is had references in next detailed description, attached drawing forms a part of this paper.In the accompanying drawings, unless up and down
Text states otherwise, and otherwise similar symbol usually identifies similar component.It is retouched in detailed description, attached drawing and claim
The illustrated embodiment stated is not intended to be limited.Without departing substantially from the spirit or scope of theme described in this paper the case where
Under, it can use other embodiments, other variations can also be made.
In general, epidermis electronic equipment may include sheet electron circuit.The thin layer is supported by barrier layer, and optionally by base
The encapsulation of plate layer.The equipment is configured to be attached to skin or its hetero-organization or otherwise engages skin or its hetero-organization (example
Such as by via jointing material be fixed to skin on), by external pressure (such as by surround or around physical feeling winding material
The pressure that material (for example, fabric, clothes, gloves, bandage etc.) provides) it is held in place, it is fixed on textile, fabric, clothing
In clothes, accessory (such as gloves, socks, fingerstall etc.) etc..The equipment is additionally configured to that electronic circuit is allowed to be bent without being damaged
It is bad.Epidermis electronic equipment includes the electronic equipment for measuring various parameters.In general, epidermis electronic equipment can be used for various medical treatment
Using.
With reference to Figure 1A, the embodiment of epidermis electronic equipment 100 is shown as including substrate layer 105.Epidermis electronic equipment
100 further include the electronic device layer 107 between substrate layer 105 and barrier layer 109.Electronic device layer 107 is worn with view 110
Substrate layer 105 is crossed to show.It include unit 120 in electronic device layer 107.Electronic equipment 100 is illustrated as being attached on epidermis
In surfaces for attachment 103.
Substrate layer 105 is transmitted in surfaces for attachment 103 convenient for epidermis electronic equipment 100.For example, substrate layer 105 can mention
For the backing for electronic device layer 107 to be transferred to surfaces for attachment 103.Then substrate layer 105 can be from electronic device layer 107
Removing, is attached to electronic device layer 107 in surfaces for attachment 103 via barrier layer 109.Substrate layer 107 can also be in processing table
Protection is provided during skin electronic equipment 100 for electronic device layer 107.Substrate layer 105 also provides support for electronic device layer 107.
Barrier layer 109 can be the elastomer or polymer for being suitable for contacting with organic organization.In some embodiments, barrier layer
109 are biocompatible materials or are inert material in other cases.In some embodiments, barrier layer 109 can have
There is low elastic modulus, for example, it has the elasticity for the elasticity modulus for being substantially less than (for example, being less than half) surfaces for attachment 103
Modulus.For example, barrier layer 109 may include low modulus polymers material.Such as PDMS or BASF.For example, substrate layer 105 can be with
It is rubber or silicone material.In some embodiments, substrate layer 105 can be water-soluble.By epidermis electronic equipment
After 100 are transferred in surfaces for attachment 103, substrate layer 105 can be dissolved.In some embodiments, substrate layer 105 does not need
It is biocompatible, because it is completely or partially moved after epidermis electronic equipment 100 is transferred in surfaces for attachment 103
It removes.Substrate layer 105 is that electronic device layer 107 provides the influence for being protected from external damage source.External damage source may include wet
Gas, physical damage (for example, from the user for touching epidermis electronic equipment 100), electrical interference, magnetic disturbance etc..
In one embodiment, surfaces for attachment 103 is the skin of user.In other embodiments, surfaces for attachment 103 is wrapped
Include other organs.For example, surfaces for attachment 103 can be bone, musculature, heart, lung etc..In some embodiments, it is attached
Surface 103 is attachment or the bandage that will be attached to skin or other organs.In some embodiments, surfaces for attachment 103 is all
Such as gloves, fingerstall covering.
Epidermis electronic equipment 100 keeps contacting with surfaces for attachment 103 by bringing into conformal contact.In some embodiments, table
Skin electronic equipment 100 is contacted by atomic force or the Van der Waals interaction holding being in close contact with surfaces for attachment 103.At other
In embodiment, epidermis electronic equipment 100 keeps contacting with surfaces for attachment 103 by using adhesive.It can be electric by epidermis
Sub- equipment 100 applies adhesive after being placed in surfaces for attachment 103.For example, adhesive can be the spray on bandage
Or it can be adhesive tape.It can also include component of the adhesive as barrier layer 109.
According to an embodiment, barrier layer 109 is at least partially around electronic device layer 107.In some embodiments,
Barrier layer 109 surrounds entire epidermis electronic device layer 107.In other embodiments, barrier layer 109 only with substrate layer 105
Electronic device layer 107 is coated on opposite surface.Barrier layer 109 can also partly coat electronic device layer 107, so that electric
It can be contacted between the element or unit of sub-device layer 107 and surfaces for attachment 103.
A is continued to refer to figure 1, electronic device layer 107 is between substrate layer 105 and barrier layer 109.Barrier layer 109 and/or
Substrate layer 105 provides support for the element of electronic device layer 107.The substrate (shown in dotted line) that passes through of view 110 shows electronics
Device layers 107.In one embodiment, electronic device layer 107 includes 120 array of unit.Unit 120 includes individual sensor
Or component.Unit 120 is also communicated with the other component in electronic device layer 107.In some embodiments, unit 120 can be with
It communicates with one another or is communicated with the subset of other units 120 in epidermis electronic equipment 100.Unit 120 can also be with other yuan
Part communication.For example, unit 120 can be with power supply, control circuit and/or communication apparatus communication.Unit 120 can also include connection
So that power can be transmitted to the component in unit, component input/output and/or the multiplex electronics being to and from unit.
In some embodiments, unit 120 may include sensor, such as accelerometer, inclinometer, magnetometer or gyroscope.Consider
To small-scale epidermis electronic equipment 100 and associated components, these sensors can be MEMS (MEMS) type;MEMS
Accelerometer, gyroscope and inclinometer can be commercially available from multiple suppliers.Sensor is also possible to integrated circuit or on piece
A part of system (SOC) is supported by it.Unit 120 can also include interaction equipment, such as drug delivery system, electricity
Pole, motion capture markers etc..Interaction equipment is also possible to MEMS, a part of integrated circuit or by integrated circuit support
Part or SOC.According to various alternate embodiments, unit 120 may include convenient for sensor output, transformer, amplifier, use
In the circuit of the multiplexing of the circuit of processing data and control signal, one or more transistors etc..
Figure 1B shows the cross-sectional view of an embodiment of epidermis electronic equipment 100.Substrate layer 105 be relative to
The top of surfaces for attachment 103 and electronic device layer 107 is protected to exempt to be affected by.Barrier layer 109 and connection table
Face 103 contacts and protects electronic device layer 107 from the influence of surfaces for attachment 103.Electronic device layer 107 is located at barrier layer 109
Between substrate layer 105.Electronic device layer 107 is shown as with the unit 120 being located therein.
As previously mentioned, surfaces for attachment 103 can be the skin of user.Epidermis electronic equipment 100 is attached to by barrier layer 109
In surfaces for attachment 103.Also protect the electronic component of epidermis electronic equipment 100 from as caused by surfaces for attachment 103 in barrier layer 109
Damage.The electronic device layer 107 of electronic component including epidermis electronic equipment 100 is coupled on barrier layer 109.Finally, substrate
Layer 105 is coupled on electronic device layer 107.Substrate layer 105 can provide surface, construct epidermis electronic equipment on a surface
100, which also protects the electronic component of epidermis electronic equipment 100, and/or promotes epidermis electronic equipment 100 and surfaces for attachment
103 attachment (for example, the removing surface that can be caught when being attached epidermis electronic equipment 100 is provided).
In an alternate embodiment, epidermis electronic equipment may include the subset of above-mentioned layer.For example, epidermis electronic equipment 100
It can only include barrier layer 109 and electronic component as described herein.Barrier layer 109 can protect electronic component, and epidermis electronics is set
Standby 100 are attached to surfaces for attachment 103, and provide the surface of building epidermis electronic equipment 100.Substrate layer 105 is that epidermis electronics is set
Standby 100 selectable unit (SU).
Fig. 2A shows the schematic diagram of a part of the epidermis electronic equipment 100 according to an embodiment, and shows
The sensor and sensor combinations that can be used.In some embodiments, epidermis electronic equipment 100 includes one or more single
Axis accelerometer 700.Each accelerometer is located in one in unit 120.Single-axis accelerometer 700 can be with such as first
The angle positioning of angle 720 and second angle 730 etc.Some embodiments of epidermis electronic equipment 100 include that multiaxis accelerates
Degree meter 710.
In one embodiment, epidermis electronic equipment 100 includes two or more single-axis accelerometers 700.It is each to add
Speedometer is a part of individual unit 120.Other portions of unit 120 promotion single-axis accelerometer 700 and electronic device layer 107
Communication between part.Unit 120 may include one or more transistors.As shown in the view 110 being shown in broken lines, single shaft adds
Speedometer 700 is a part of electronic device layer 107.Single-axis accelerometer 700 is the MEMS along single axis measurement acceleration
Accelerometer.A single-axis accelerometer 700 is shown with the positioning of first angle 720.Show another single-axis accelerometer
700 with the positioning of second angle 730.By positioning two single-axis accelerometers, epidermis electronic equipment with different angle 720 and 730
100 rotation and orientation can be exported according to sensor to be determined.Different angles 720 and 730 can lead to single-axis accelerometer
Along different plane positionings.Single-axis accelerometer can be slightly or completely opposite.Some embodiment party of epidermis electronic equipment 100
Case includes multi-axial accelerometer 710.
It may include the additional sensor in the embodiment of epidermis electronic equipment 100 that Fig. 2 B, which is shown,.These are additional
Sensor may include one in uniaxial inclinometer 703, multiaxis inclinometer 713, single axis gyroscope 705 and multiaxis gyroscope 715
It is a or multiple.Inclinometer can be used for measuring orientation of the epidermis electronic equipment 100 relative to gravity direction.One uniaxial inclinometer
703 can be positioned with first angle 723.Another uniaxial inclinometer 703 can be positioned with second angle 733.By with difference
Angle 723 and 733 positions two uniaxial inclinometers, can be exported according to sensor and determine epidermis electronic equipment 100 relative to weight
Two components in the orientation in power direction.Different angles 720 and 730 can cause uniaxial inclinometer fixed along different axis
Position.Uniaxial inclinometer can be used for measuring the pitch angle or roll angle relative to gravity direction.Some realities of epidermis electronic equipment 100
The scheme of applying includes multiaxis inclinometer 713, that is, to measure pitch angle or roll angle.In some embodiments, electronic device layer
107 include one or more gyroscopes to measure the angular speed of epidermis electronic equipment 100.In some embodiments, electronics fills
Setting layer 107 includes one or more single axis gyroscopes 705 (for example, MEMS vibrational structure gyroscope).One single axis gyroscope 705
It can be positioned with first angle 725.Another single axis gyroscope 705 can be positioned with second angle 735.By with different angle
725 and 735 two single axis gyroscopes of positioning can export the two of the angular speed for determining epidermis electronic equipment 100 according to sensor
A component.Different angles 725 and 735 can cause uniaxial inclinometer to orient along different axis.Single axis gyroscope can be used for
Measure pitch angle, roll angle and/or yaw angle.Some embodiments of epidermis electronic equipment 100 include multiaxis gyroscope 715.
Fig. 2 C shows the embodiment of epidermis electronic equipment 100, wherein arranging two sensors to measure epidermis electricity
The movement (angle and/or translation) of sub- equipment 100.Single-axis accelerometer 704 is shown it and measures the Z that axis is parallel to three-dimensional space
Axis is simultaneously positioned along the Z axis.Single-axis accelerometer 704 has the first angle 720 that zero angle is limited with axis Z.Show second
Single-axis accelerometer 706, measurement axis are not aligned with axis Z.Second accelerometer 706 has by the second angle relative to Z axis
The measurement axis of 730 definition.The angle can be greater than zero degree.The measurement axis of second single-axis accelerometer 706 is further by angle 731
It limits, angle 731 limits the measurement axis relative to X-Y plane.Shown in embodiment as shown, 704 He of single-axis accelerometer
706 are configured as slightly with respect to (for example, single-axis accelerometer 704 is aligned with Z axis, and the second single-axis accelerometer 706 is positioned to
Second angle 730 is 30 angle and 731 degree of angle are 15 degree).In some embodiments, multiple single-axis accelerometers 703
It is configured as measuring the acceleration along X, Y and Z axis.In a further embodiment, in addition to measuring along X, the acceleration of Y and Z axis
Except degree, additional single axis gyroscope is also configured to measure the rotation around X, Y and Z axis.In some embodiments, one or
Multiple single shaft inclinometers replace one or more accelerometers or gyroscope.Uniaxial inclinometer can also be used for providing redundant measurement.
In some embodiments, the measured value provided by one or more inclinometers is used to verify the epidermis determined using other data
The orientation of electronic equipment.In some embodiments, single axis gyroscope replaces one or more accelerometers.Single axis gyroscope
It can be used for providing redundant measurement.In some embodiments, accelerometer, inclinometer and/or gyroscope include multiaxis acceleration
Meter, multiaxis inclinometer and/or multiaxis gyroscope.
In one embodiment, single-axis accelerometer 704 is located on axis.Second single single-axis accelerometer 706 is along phase
Same axis positioning is still from 704 transverse shift of accelerometer.Single-axis accelerometer 704 and the second single single-axis accelerometer 706
It is positioned to measure along same axis but with the acceleration of contrary sign.Acceleration along axis will be read in two accelerometers
It is negative acceleration that one, which is another in positive acceleration and two accelerometers,.Therefore, when there are acceleration without revolving
When turning, the summation of the acceleration measured by single-axis accelerometer 704 and the second single single-axis accelerometer 706 will be zero or be about
Zero (for example, it is contemplated that arrive measurement error etc., about zero).It will lead to by the rotation of two accelerometer measures by two accelerometers
The net acceleration of measurement.Therefore, the single-axis accelerometer for two displacements being relatively aligned along same axis can detecte or survey
Amount rotation, i.e. angular speed and/or angular acceleration.
In general and Figure 1A -2C is referred to, sensor (for example, accelerometer, inclinometer, gyroscope etc.) is in epidermis electronics
Positioning and orientation, allow to the angular movement and orientation of measuring device in the electronic device layer 107 of equipment 100.Many configurations are
It is possible, and the embodiments described herein is not intended to be limited.By using the opposite of discussed type or slightly phase
Pair single-axis sensors, epidermis electronic equipment 100 can be configured as the orientation and/or angular movement of measuring device, and therefore survey
The orientation and/or angular movement of surfaces for attachment 103 attached by scale skin electronic equipment 100 (for example, the physical feelings such as limbs).?
In some embodiments, multiple single-axis sensors are used to measure the orientation of epidermis electronic equipment 100.For example, six uniaxial acceleration
Degree meter 103 can be used for measuring a total of six freedom degree.Six single-axis accelerometers can measure X-axis acceleration, Y-axis acceleration and
Z axis acceleration and the pitching angular acceleration around these axis, rolling angular acceleration and yaw angular acceleration.In some embodiment party
In case, identical function is realized using the combination of multiple sensors type.For example, three single-axis accelerometers can be configured
For measurement X-axis acceleration, Y-axis acceleration and Z axis acceleration, wherein the other three single axis gyroscope is configured as measurement about this
Rate of pitch, angular velocity in roll and the yaw rate of a little axis.Other sensors can also be used for measurement epidermis electronic equipment 100
With orientation, rotation and/or the position of surfaces for attachment 103.For example, measuring the more of X-axis acceleration, Y-axis acceleration and Z axis acceleration
Axis accelerometer can be used cooperatively with multiaxis gyroscope, with measurement around the rate of pitch of these axis, angular velocity in roll and partially
Navigate angular speed.
Fig. 3 A shows the decomposition diagram of an embodiment of epidermis electronic equipment 100.The embodiment includes substrate
Layer 105, the electronic device layer 107 including material layer 111 and barrier layer 109.It further include stopping opening 119 in barrier layer 109.
Substrate layer 105 can provide physical support for electronic device layer 107.Substrate layer 105 can also promote epidermis electronics
Equipment 100 (it includes electronic device layer 107 and barrier layer 109) is attached to surfaces for attachment 103.In some embodiments, base
Plate layer 105, which can be, to be abandoned or is dissolved after epidermis electronic equipment 100 is already attached to surfaces for attachment 103.
Electronic device layer 107 is shown as including the component in material layer 111.Layer 111 can be used for for electronic device layer 107
Component provide mechanical support.It can also be used in the manufacture for promoting electronic device layer 107.In some embodiments, electronics fills
It sets layer 107 and (for example, without layer of support material) is only constituted by electronic component therein.In such a case, it is possible in substrate layer
105 or barrier layer 109 on manufacture electronic device layer 107.Substrate layer 105 or barrier layer 109 provide manufacture and use epidermis electronics
Mechanical support needed for equipment 100.
Substrate layer 105 provides protection for the component of electronic device layer 107.Substrate layer 105 can prevent external force and element dry
Disturb the function of electronic device layer 107.For example, substrate layer 105 can prevent moisture from reaching electronic device layer 107.In some implementations
In scheme, substrate layer 105 can also prevent the physical damage of the component to electronic device layer 107.Substrate layer 105 can also shield
Electronic device layer 107 is influenced from foreign radiation sources, magnetic field, light etc..In some embodiments, barrier layer 109 is permeable
Or it is semi-permeable.For example, barrier layer 109 can be it is semi-permeable so that drug can pass through barrier layer 109 shift.
As depicted in FIG., barrier layer 109 may include one or more blocking openings 119.In one embodiment, stop opening
119 correspond to specific unit or 120 groups of unit.The element and surfaces for attachment for stopping opening 119 to enable electronic device layer 107
103 directly contact.Sensor 770, which can pass through, stops opening 119 directly to contact with surfaces for attachment 103.In some embodiments
In, epidermis electronic equipment 100 can advantageously promote the behaviour of one or more sensors 770 configured with opening 119 is stopped
Make.For example, allowing directly to contact the precision that the alignment sensor of such as accelerometer etc can be improved with surfaces for attachment 103.
Similarly, the sensor of such as humidity sensor etc can have improved reading if contacting with surfaces for attachment 103.Barrier
Opening 119 is hindered to be also convenient for the operation of interactive device 780.It, can be with if interactive device 780 is directly contacted with surfaces for attachment 103
More effectively operate.
Fig. 3 B shows the electronic building brick 113 according to an embodiment.Electronic building brick 113 includes being located at electronic device layer
Component in 107.As shown, electronic building brick 113 and component therein can not be supported by additional material layer 111 (for example,
Electronic building brick 113 can only include circuit and component, without backing material, also without substrate).In some embodiments,
Electronic building brick 113 is generated on substrate layer 105 and (is not shown in Fig. 3 B).Electronic building brick 113 may include unit 120, sensor
770, interactive device 780, the power supplys 740 for being connected to other component via power connection 741, are connected to via communication connection 753
The communication equipment 750 of other component, control circuit 760 connect 751 with input/output.In some embodiments, control circuit
760 further include memory 761, processor 763 and multiplexer 765.
Interactive device 780 enables epidermis electronic equipment 100 to interact with surfaces for attachment 103.Interactive device 780 can be matched
It is set to apply the form of voltage and/or drug conveying and provide stimulation to surfaces for attachment.For example, interactive device 780 can be
MEMS delivery system.Alternatively, interactive device 780 can be the electricity for the voltage of application to be transmitted to surfaces for attachment
Pole.Interactive device 780 also enables external equipment to interact with epidermis electronic equipment 100.For example, camera or motion capture system can
To monitor the position of epidermis electronic equipment.Interactive device 780 can be passive movement and capture label.Interactive device 780 can also be with
It is active movement capture label.In some embodiments, interactive device 780 is the light-emitting diodes controlled by control circuit 760
It manages (LED).LED intermittently can be illuminated so that motion capture system can record the orientation and/or shifting of epidermis electronic equipment 100
It is dynamic.The data can be used for calibration surface electronic equipment 100.It can also estimate table in the data collected according to sensor 770
It is used as constraint when the orientation and movement of skin electronic equipment.For example, the bearing data from motion capture system can make
It is used as boundary or limitation when calculating the orientation of physical feeling with epidermis electronic equipment 100 (for example, if motion capture system determines
Arm has been rotated through 30 degree, then can be restricted to 30 degree by the corresponding calculating that epidermis electronic equipment 100 carries out).Further
Embodiment in, interactive device 780 include biosensor.Biosensor can be wearable sensors.Physiology sensing
Device can be by skin contact with user or with the skin of user close to providing the information about user.For example, physiology
Sensor may include heart rate sensor, respiration transducer, heat sensor, blood pressure sensor, hydration sensor device, Oximetry sensing
Device, electrocardiograph, electroencephalograph and/or electromyograph.
Multiple interactive devices 780 may include in the single electronic device layer 107 of epidermis electronic equipment 100.Multiple friendships
Mutual equipment 780 can also be located on more than one epidermis electronic equipment 100.Multiple epidermis electronic equipments 100 and corresponding more
Communication equipment 750 and each epidermis electronic equipment on each epidermis electronic equipment 100 can be used in a interactive device 780
Control circuit 760 on 100 is coordinated and is controlled.
Communication equipment 750 may include in electronic building brick 113.Communication equipment 750 is to and from table by communication connection 753
Face electronic equipment 100 provides data transmission.Communication connection 753 can be communication equipment 750 and another source or data sink
Between wired or wireless connection.For example, communication connection 753 can be through wireless network (for example, WiFi, Zigbee, bluetooth
Deng) connection, wireline interface (for example, Ethernet, USB, firewire (Firewire) etc.) or other communication connection (for example, infrared
Line, optics, ultrasonic wave etc.).In some embodiments, communication equipment 750 is wireless networking device or wired networked devices,
It establishes communication connection 753 and data/signal is sent and/or received by communication connection 753.
Power is transferred to the other component in electronic device layer 107 by power connection 741 from power supply 740.Power connection 741
From component (such as interactive device 780 He of the power supply 740 into communication equipment 750, control circuit 760, unit 120 and unit 120
Sensor 770) power is provided.Power connection 741 can be wired or wireless connection.Power connection 741 can be conductor wire (example
Such as, copper, aluminium etc.).Power connection 741 can be semiconductor.In the case where power connection 741 is wired connection, power connection
741 are configured as keeping mechanical integrity when the component of electronic device layer 107 is moved relative to each other.For example, power connects
741 can be the sufficiently long electric wire of length so that component can move without will lead to power connection 741 deformation be enough to disconnect
Connection.Power connection 741 is also possible to the wireless connection for transmission power (for example, directly induction, resonance magnetic induction etc.).
Component of the power supply 740 into electronic device layer 107 provides power.In one embodiment, power supply 740 is battery.
For example, power supply 740 can be disposable battery, rechargeable battery and/or detachable battery.In some embodiments, power supply
740 are configured such that and can recharge in the case where not removing power supply 740 from electronic device layer 107 to power supply 740.Example
Such as, power supply 740 can be configured as the rechargeable battery recharged by wireless charging (for example, induction charging).
In other embodiments, power supply 740 is configured as receiving direct current from the source outside electronic device layer 107.In other reality
It applies in scheme, power supply 740 is configured as receiving alternating current from the source outside electronic device layer 107.Power supply 740 may include transformation
Device.In some embodiments, power supply 740 is configured as receiving power (for example, power supply 740 is made to be to be configured from radio sources
For the coil for receiving power by induction).According to various alternate embodiments, power supply 740 can be capacitor, can be matched
It is set to by wired or wireless source, one or more solar batteries or is configured as filling by the Meta Materials of microwave offer power
Electricity.
With continued reference to Fig. 3 B, input/output connection 751 can be the conducting wire between unit 120 and control circuit 760 and connect
It connects.Input/output connection 751 is configured such that connection can be bent and deform without by mechanical breakdown.This
In the case of, input/output connection 751 is configured as movement and deformation phases in epidermis electronic equipment 100 due to surfaces for attachment 103
Between connection between maintenance unit 120 and control circuit 760.In some embodiments, input/output connection 751 passes through packet
Include the conducting wire for the extra length that tie point is separated from each other and can deformation while keeping mechanical integrity.For example, defeated
Enter/export connection 751 can be with relaxation conducting wire so that two or more components can be moved relative to each other and
The mechanical deterioration that input/output will not be caused to connect.In some embodiments, input/output connection 751 is conductor wire (example
Such as, copper, aluminium etc.).Input/output connection 751 can be semiconductor.In some embodiments, input/output, which connects 751, is
It is wirelessly connected.
Input/output connection 751 enables the component in unit 120 to transfer data to control circuit 760.Unit 120
Interior component can connect 751 by input/output and output data to control circuit.For example, being located at the sensing in unit 120
Measurement data can be output to control circuit 760 across input/output connection 751 in the form of a voltage by device 770.Input/defeated
Connection 751 also enables control circuit and the component communication in unit 120 out.Control circuit 760 can be connected by input/output
It connects 751 component into unit 120 and sends input.For example, control circuit 760 can send input signal to interactive device 780,
To make interactive device 780 that drug or chemical substance are transported to surfaces for attachment 103.Unit 120 can also promote to communicate.Control
Circuit 760 can also use input/output connection 751 to send calibration signal to sensor 770 or interactive device 780.Some
In embodiment, power connection 741 connects 751 with input/output and is integrated into single connection.It can be with for example, being integrated and connected
Power and input/output are provided by modulation or other variable signals.
In some embodiments, electronic building brick 113 includes control circuit 760.Control circuit 760 can also include multichannel
Multiplexer 765, processor 763 and memory 761.Processor 763 can be implemented as general processor, specific integrated circuit
(ASIC), one or more field programmable gate arrays (FPGA), digital signal processor (DSP), groups of processing component or
Other suitable electronic processing components.Memory 761 be by store be convenient for various processing described herein data and/or based on
One or more equipment (for example, RAM, ROM, flash memory, hard-disc storage etc.) of calculation machine code.Memory 761 can be or including
Non-transient volatile memory or nonvolatile memory.Memory 761 may include database element, target code component,
Script component or message structure for supporting any other type of various activities and message structure described herein.Memory
761 can be communicatively connected to processor 763, and provide the calculating for executing process described herein to processor 763
Machine code or instruction.Multiplexer 765 can be configured as that allow multiple sensors 770 and/or interactive device 780 to share defeated
Enter/export connection 751.In some embodiments, unit 120 additionally aids signal of the multiplexing from multiple components.
In some embodiments, control circuit 760 is configured as receiving data from sensor 770.For example, control circuit
760 can receive the acceleration information of the voltage form measured from acceleration transducer.The data can be led to by control circuit 760
Cross the reception of multiplexer 765.Sensing data can be stored in memory 761 by control circuit 760.Control circuit 760
Sensing data can be output to communication equipment 750.In some embodiments, control circuit 760 is additionally configured to biography
Sensor 770 sends control signal.For example, control circuit 760 can calibrate sensor by sending control signal to sensor
770.Control circuit 760 can also close or open sensor 770.For example, control circuit 760, which can be sent, causes unit 120
Sensor 770 is connect to the control signal of 741 disconnections with power.Control circuit 760 is also an option that using processor 763 and deposits
Reservoir 761 receives data from which sensor.Control circuit 760 can receive control signal from communication equipment 750.In some realities
It applies in scheme, control circuit 760 also generates control signal using processor 763 and memory 761.For example, control circuit 760 can
In response to sending control signal from the received abnormal data of sensor with closure sensor 770.Control circuit 760 can also be rung
Ying Yu sends control signal from the data of other sensors 770 with closure sensor 770.For example, if detecting minimum add
Speed can then close some sensors 770 to save power supply 740.When a plurality of sensors are used, a sensor 770 can
To be maintained at on-position.When detecting increased acceleration activity, control circuit 760 can reactivate or open residue
Sensor 770.
In some embodiments, control circuit 760 is additionally configured to receive data from interactive device 780.For example, control
Circuit 760 can receive medication delivery data from medicament delivery device.The data can pass through multiplexing by control circuit 760
Device 765 receives.The data can be stored in memory 761 by control circuit 760.Control circuit 760 can be by interactive device
Data are output to communication equipment 780.In some embodiments, control circuit 760 is additionally configured to send control signals to friendship
Mutual equipment 750.For example, control circuit 760 can send control signal to medicament delivery device, so that the equipment is by medicament administration
To surfaces for attachment 103.Interactive device 780 can also be closed and be opened to control circuit 760.
Control circuit 760 can receive signal from the other component in electronic device layer 107.For example, control circuit 760 can
To receive signal from communication equipment 750.Control circuit 760 may also receive from the signal of power supply 740.For example, control circuit
760 can receive the expression from power supply 740, and how many power is available signal.This point can be used in control circuit 760
Take further action.The information or other information are transmitted to for example, communication equipment 750 can be used in control circuit 760
Another equipment.Control circuit 760 can also by control electronic device layer 107 include unit 120, interactive device 780 and/or
Component including sensor 770 is taken action.In some embodiments, the function of control circuit 760 by unit 120 electricity
Road executes.For example, unit 120 may include the above-mentioned function for enabling the network of unit 120 or unit 120 to execute control circuit 760
The transistor and/or other component of energy.In other embodiments, control circuit 760 is located at not in electronic device layer 107
Region in.In one embodiment, communication equipment 750 can send and receive control signal and data.For example, external control
Circuit can execute above-mentioned function, and wherein communication equipment 750 is in the component of electronic device layer 107 (for example, sensor 770 and friendship
Mutual equipment 780) and external control circuit between relay data.
Sensor 770 in electronic building brick 113 may include the sensor for being configured to measurement bearing data.Bearing data can wrap
Include the acceleration about surfaces for attachment 103, orientation, the data of movement, angular movement and/or rotation.For example, sensor 770 can wrap
Single-axis accelerometer, multi-axial accelerometer are included, in single axis gyroscope, multiaxis gyroscope, uniaxial inclinometer or multiaxis inclinometer
It is one or more.In some embodiments, the combination of these sensors is for measuring acceleration, orientation, movement, angular movement
And/or rotation.In some embodiments, sensor 770 includes the sensor for measuring the characteristic of surfaces for attachment 103.Example
Such as, sensor 770 can be humidity sensor, electrode, temperature sensor (for example, thermistor, thermocouple etc.), optical sensing
Device, hydration sensor device etc..Interactive device 780 may include being configured as changing surfaces for attachment 103 or providing to control circuit 760
The equipment of data.For example, interactive device 780 may include medicament delivery device, chemical delivery equipment, electrode, motion-captured biography
Sensor, LED etc..
Fig. 4 A shows the embodiment for being expressed as another epidermis electronic equipment of epidermis electronic equipment 101.In some realities
It applies in scheme, big component is contained in and the sensor and/or interactive device point in electronic building brick 113 by epidermis electronic equipment 101
In the shell opened.These big components can be located at outside the flexible patch including electronic device layer 107 and barrier layer 109.This and packet
Include the epidermis electronic equipment 100 of most of component (for example, most of component is in flexible patch) in electronic device layer 107 not
Together.Epidermis electronic equipment 101 is shown with electronic module 610.Electronic module 610 can keep power supply 740, communication equipment
Any one of 750 and/or control circuit 760 are whole.In one embodiment, electronic module 610 shows with view 110
Electronic device layer 107 out separates (for example, electronic module 610 can accommodate the component outside electronic building brick 113 and can mention
For the connection with electronic building brick 113).Electronic module 610 can be the shell comprising above-mentioned component.For example, electronic module 610 can
To be plastics or polymer shell, which, which has, leads to the access for being contained in component therein.Electronic module 610 is also possible to
Film or other protective cases.
In some embodiments, electronic module 610 makes power supply 740, communication equipment 750 and/or control circuit 760
Scale can than them in electronic device layer 107 when scale it is big.For example, power supply 740 can be bigger battery.Processing circuit
760 can be integrated circuit or SOC.In some embodiments, electronic module 610 is connected to electronics by power connection 741
Device layers 107.Electronic device module 610 can connect the 741 component (example from power supply 740 to electronic device layer 107 by power
Such as, sensor, interactive device etc.) power is provided.In a further embodiment, electronic module 610 also passes through input/output
Connection 751 is connected to electronic device layer 107.Electronic device module 610 can connect 751 by one or more input/output
It is connected to electronic device layer 107 and/or electronic building brick 113.This can promote other component (for example, sensor, interactive device
Deng) use.The use of multiple input/output connections 751 can partially or completely reduce the needs to multiplexing.
With reference to Fig. 4 A-4B, multi-axial accelerometer 710, multiaxis gyroscope is can be used in epidermis electronic equipment 100 and/or 101
715 and multiaxis inclinometer 713 measurement in a closed series the orientation of a point of surfaces for attachment, acceleration, movement, angular movement, rotation,
Angular speed, angular acceleration and/or position (for example, bearing data).Using the combination of these sensors, six-freedom degree can be used
Determine orientation, acceleration, movement, angular movement, rotation, angular speed, angular acceleration and/or the position of surfaces for attachment.It can be used
The measurement of six-freedom degree is realized in multiple combinations of sensor.
In some embodiments, a type of sensor is used as the constraint of the measurement to another sensor.For example, from
The data that multiaxis inclinometer 713 is collected may be used as to the data collected by multi-axial accelerometer 710 or multiaxis gyroscope 715
Constraint.The angle of gravimetric measurements relative to multiaxis inclinometer may be used as the pact integrated to accelerometer or gyro data
Beam.In some embodiments, sensor integration accelerometer.It in some embodiments, can be directly using from deviational survey
The measured value (for example, for angle relative to gravity) of instrument.Inclinometer measured value is also used as to from multiaxis acceleration
The integral of data or the integral of the data from multiaxis gyroscope 715 of meter 710 ask the inspection in derived orientation.This can be used for
Restraining error is propagated.This can also include the data verified using inclinometer measurement data from other sensors and/or test
The orientation for the epidermis electronic equipment that card is determined using other data.
Epidermis electronic equipment 100 and/or 101 can be used at the other point of other sensor group measurement surfaces for attachment
Orientation, acceleration, movement, angular movement, rotation, angular speed, angular acceleration and/or position.Epidermis electronic equipment 100 and/or
101 can be used these other sensors (for example, multi-axial accelerometer, multiaxis gyroscope 715 and/or multiaxis inclinometer
713) orientation at multiple points to measure surfaces for attachment 103 and an epidermis electronic equipment 100, acceleration, movement, angle fortune
Dynamic, rotation, angular speed, angular acceleration and/or position.
In some embodiments, orientation, acceleration, shifting are measured at multiple points using multiple epidermis electronic equipments 100
Dynamic, angular movement, rotation, angular speed, angular acceleration and/or position.Measurement from multiple epidermis electronic equipments 100 and/or 101
Value (measured value of epidermis electric room) may be used as the constraint to other sensors measured value and integral.Processing can be passed through
The application constraint of circuit 513.In some embodiments, it is constrained by the application of control circuit 760.
In some embodiments, multiple 107 (each individual barrier layer 109 with their own of electronic device layer
With substrate layer 105 (for example, multiple epidermis electronics patches)) it is connected to identical electronic module 610.This can enable can utilize list
A Power Support 740, communication equipment 750 and control circuit 610 are measured and are interacted at multiple of surfaces for attachment 103.
With continued reference to Fig. 4 B, electronic module 610 can be connected to data acquisition and processing equipment via communication connection 753
510.Data acquisition and processing equipment 510 include communication equipment 750.Communication equipment 750 makes data acquisition and processing equipment 510
The communication equipment that data can be received and/or control signal and send data and/or control signal in electronic module 610
750.In some embodiments, the communication equipment 750 in data acquisition and processing equipment 510 can receive data and/or control
Signal processed and by data and/or control signal be sent in the electronic device layer 107 of epidermis electronic equipment 100 and/or 101
Communication equipment 750.
In some embodiments, data acquisition and processing equipment 510 further include processing circuit 513.Processing circuit 513 from
Epidermis electronic equipment 100 and/or 101 receives data.Processing circuit 513 analyzes data.For example, processing circuit 513 can be used
Algorithm calculates or estimates orientation, acceleration, movement, rotation, angular speed and/or the position of epidermis electronic equipment 100 and/or 101
It sets.These algorithms may include Kalman (Kalman) filter, kinetic filter, custom algorithm (a customized
algorithm).Processing circuit 513 can calculate or estimate epidermis electronic equipment 100 and/or 101 or multiple epidermis electronic equipments
The direction of one or more positions on 100 and/or 101, acceleration, movement, angular movement, angular acceleration, rotation, angular speed
The orientation and/or.
In some embodiments, processing circuit 513 also sends control signals to epidermis electronic equipment 100.For example, number
Communication equipment 750 can be used to the transmission control of epidermis electronic equipment 100 with the processing circuit 513 of processing equipment 510 according to obtaining
Signal, to calibrate sensor 770.In order to promote above-mentioned function, processing circuit 513 and/or data acquisition and processing equipment 510 can
To include one or more of processor and memory.
Data acquisition and processing (DAP) equipment 510 can calculate equipment output to other and transport about orientation, acceleration, movement, angle
Dynamic, rotation, angular speed, angular acceleration and/or position data, control signal and/or estimation or calculating.Data acquisition and processing (DAP)
Equipment 510 can also be exported to one or more epidermis electronic equipments 100 and/or 101.This may include will be by an epidermis electricity
The data that sub- equipment 100 or 101 is collected are output to the second epidermis electronic equipment 100 or 101.In some embodiments, data
It obtains and processing equipment 510 includes user interface.In other embodiments, data acquisition and processing equipment 510 are by other
Computer control.In some embodiments, data acquisition and processing equipment 510 can also output data to another calculating
Machine.In some embodiments, there is power supply 740, communication equipment 750 and the control circuit being integrated in electronic device layer 107
760 epidermis electronic equipment 100 is connected to data acquisition and processing equipment 510.
Fig. 5 shows the embodiment of the epidermis electronic equipment 100 and 101 to communicate with one another.Two or more epidermises electricity
Sub- equipment 100 or 101 can be communicated with one another by communication connection 753 and communication equipment 750.Communication connection 753 can be wireless
Connection or wired connection.Multiple epidermis electronic equipments 100 can also be communicated with data acquisition and processing equipment 510.Use two
Or more epidermis electronic equipment 100 or 101 make it possible to measure multiple points simultaneously.For example, can be by using two or more
A epidermis electronic equipment 100 come relative to another point orientation, acceleration, movement, rotation, angular speed, angular acceleration and/or
Position measures orientation, acceleration, movement, rotation, angular speed, angular acceleration and/or the position of a point.
Fig. 6 shows an embodiment of the multiple epidermis electronic equipments 100 used by user 680.In an embodiment
In, multiple epidermis electronic equipments 100 are attached to user 680.Epidermis electronic equipment 100 can be used wireless communication connection 753 into
Row communication.Can transfer data to may include processing circuit 513 data acquisition and processing equipment 510.Outside sensing is set
Standby 550 can be also used for collecting the information about user 680 and/or epidermis electronic equipment 100.External sensor device 550 may be used also
To utilize 753 transmission data of wireless communication connection.
In one embodiment, epidermis electronic equipment 100 is placed in the various physical feelings of user 680.For example, epidermis
Electronic equipment can be placed on finger, hand, forearm, upper arm, foot, leg, head etc..In some embodiments, user 680
Surfaces for attachment 103 is his or her skin.Each epidermis electronic equipment can use uniaxial or multi-axial accelerometer, single shaft or more
One or combinations thereof in axis inclinometer or single shaft or multiaxis gyroscope measures orientation.Epidermis electronic equipment 100 can be used
Communication connection 753 and communication equipment 750 communicate with one another and/or communicate with data acquisition and processing equipment 510.In the embodiment
In, communication connection 753 is illustrated as being wirelessly connected.In some embodiments, epidermis electronic equipment 100 can form network (example
Such as, ad hoc network).Data and control signal can be transmitted to epidermis electronic equipment 100 by the network of epidermis electronic equipment 100
Other networks.Multiple networks of epidermis electronic equipment 100 can be with shared information.This can enable can be obtained by individual data
Data are collected from multiple networks (for example, one network of each user, has multiple users) with processing equipment 510.
Fig. 6, which also shows two or more epidermis electronic equipments 100, can be used for measuring surfaces for attachment relative to each other
Parameter (for example, orientation, acceleration, movement, angular movement, rotation, angular speed, angular acceleration and/or position).As shown, can
With the surfaces for attachment parameter of the surfaces for attachment parameter measurement forearm relative to upper arm.This makes epidermis electronic equipment 100 and data
It obtains and processing equipment 510 can determine that direction or movement of the forearm relative to upper arm.A body can be measured in this way
Relative bearing, acceleration, movement, angular movement, rotation, angular speed, angular acceleration and/or the position at position and another physical feeling
It sets.For another example can determine the orientation of finger relative to hand.Epidermis electronic equipment 100 can also be used to measure surfaces for attachment parameter
Variation.These changes are determined for the movement of user, for example, gait, gesture, athletic performance (for example, golf,
Throwing etc.) etc..The measurement can utterly be carried out or relative to other one or more by single epidermis electronic equipment 100
A epidermis electronic equipment 100 carries out.For example, the variation of orientation and angular speed can be measured when the leg of user is mobile.The measurement
It can utterly be carried out by epidermis electronic equipment 100.The measurement can also be surveyed relative to the mobile trunk of user 680
Amount.In this case, measured value is collected by the epidermis electronic equipment 100 on trunk and the epidermis electronic equipment 100 on leg.Phase
Orientation and angular speed can be calculated by data acquisition and processing equipment 510.In some embodiments, single epidermis electronics is set
Standby 100 can be used for measuring the surfaces for attachment parameter at multiple positions.This may include multiple positions of multiple physical feelings.Example
Such as, single epidermis electronic equipment 100 can measure the trunk of user 680 and the orientation of leg.
Various technologies can be used to determine or estimate the orientation of user 680, accelerate in data acquisition and processing (DAP) equipment 510
Degree, movement, angular movement, rotation, angular speed, angular acceleration and/or position.Data acquisition and processing equipment 510 also can be used
Identical or other technologies determine the posture and/or gesture of user 680.These technologies may include by algorithm, Kalman filtering
Device and/or other kinetic filters are applied to the pact that measurement and/or application are provided by one or more epidermis electronic equipments 100
Beam.For example, Kalman filter can be used for estimating to attach to the orientation of the epidermis electronic equipment 100 of the physical feeling of user.Side
Position can be described by various types of state vectors, such as Eulerian angles, quaternary number etc..Because epidermis electronic equipment 100 makes
Some sensor measurement angular movements (for example, measuring angular speed by gyroscope, passing through accelerometer measures angular acceleration)
Rather than (for example, passing through inclinometer, field sensor etc.) directly measures orientation, therefore the dynamic filter based on physics can be used
Wave device (for example, Kalman filter) carrys out estimation orientation.This filter may include additional state variable (such as angular speed
And/or angular acceleration), they (for example, passing through the continuous propagation of the differential equation, pass through state by the link of state propagation model
The discrete propagation of transfer matrix).Kinetic filter includes measured value relevant to state variable (for example, angular acceleration is opposite
Acceleration measuring magnitude, the gyroscope measured value of angular speed, the inclinometer of angle orientation or field measure etc.), each measured value
May depend on single status variable or multiple state variables (for example, angular movement measured value is also generally dependent on the direction of sensor,
Therefore orientation is depended on).Kinetic filter may include the estimation to the noise in this measurement, and therefore include it to each
Probabilistic estimation of the estimation of state variable;These uncertainty estimations can be tracked at any time by filter.It can hold
It changes places and formulates kinetic filter and indicate (for example, angle is to (vs) quaternary number), different measurements to handle different state vectors
Type (combination of direct angle measurement and/or angular speed and/or angular acceleration) and different sensors are (for example, magnetic force
Meter and inclinometer, rotation is to ring laser to vibratory gyroscope).The comparison of various kinetic filters for body sensor network
It is presented on " Analysis of Filtering Methods for 3D Acceleration Signals in Body
Sensor Network”,Wei-zhong Wang,Bang-yu Huang,Lei Wang,Bulletin of Advanced
In Technology Sensors, Vol 5, No 7,2011.The document of Kalman filter for three-dimensional position estimation
It (Presentations) include: " Design, Implementation, and Experimental Results of a
Quaternion-Based Kalman Filter for Human Body Motion Tracking”,Xiaoping Yun,
Eric Bachmann,IEEE Transactions on Robotics,Vol 22,No 6,2006;"Kalman-Filter-
Based Orientation Determination Using Inertial/Magnetic Sensors:Observability
Analysis and Performance Evaluation”,Angelo Sabatini,Sensors,September 27,
2011;"Using an Extended Kalman Filter for Rigid Body Pose Estimation",Kjartan
Halvorsen,et al,Journal of Biomechanical Engineering,Vol 127,p 475(2005);And
“An Extended Kalman Filter for Quaternion-Based Orientation Estimation Using
MARG Sensors”,Joao Marins,et al,2001IEEE/RSJ International Conference on
Intelligent Robots and Systems,Maui Oct 29–Nov 3,2001.In some embodiments, constraint by
Other sources, such as model, the external sensor device of human motion etc. provide.In some embodiments, constraint can define model
It encloses, the measured value of epidermis electronic equipment 100 is considered effectively in this range.Data acquisition and processing equipment 510
Kalman or other kinetic filters can be used to combine various measured values and/or constraint.This may cause than based on one
Measurement or data point estimate preferably to the estimation of known variables known variables.Furthermore it is possible to reduce signal noise and not
Accuracy.
Multiple epidermis electronic equipments 100 can be used for the state of measurement user 680.Epidermis electronic equipment can be used for surveying
Measure the posture of user 680.By measuring orientation, acceleration, movement, angular movement, rotation, angle speed in one or more positions
Degree, angular acceleration and/or position, can determine the posture of user.It is, for example, possible to use the inclinometers for measuring various physical feelings
Determine that user 680 is seated, stands or recumbency with accelerometer.If a people is seated, the deviational survey on trunk and leg
Instrument is read the different of angle relative to gravity are provided.Indicate the corresponding accelerometer or gyroscope of little or no acceleration
Reading can indicate that user 680 is just seated.Alternative configuration and sensor can be used for detecting various postures.In some embodiments,
Measured posture includes the positioning of one or more physical feelings during movement or certain types of movement.For example, epidermis
Electronic equipment 100 can running when measurement user 680 posture by ensure it is appropriate in the form of or for improving form.For example,
Epidermis electronic equipment 100 can be measured when swinging golf club the posture of user 680 by ensure it is appropriate in the form of or be used for
Improvement form.In some embodiments, single epidermis electronic equipment 100 can be used for measuring the ginseng of the surfaces for attachment at multiple positions
Number.
Multiple epidermis electronic equipments 100 can be used for measuring the posture made by user 680.Given body portion can be measured
Orientation, acceleration, movement, angular movement, rotation, angular speed, angular acceleration and/or the position of position and the variation of identical parameters.
For example, the epidermis electronic equipment 100 being placed on finger, hand and arm can be used for detecting the hand made using these physical feelings
Gesture.For example, measuring the orientation of these physical feelings, acceleration, movement, angular movement, rotation, angular speed, angular acceleration and/or position
It sets and the variation of identical parameters can make it possible to explain sign language.In some embodiments, gesture is defined as one or more
Any one or more special exercises of a physical feeling.Epidermis electronic equipment 100 can measure movement, and data acquisition and
These movements can be compared by processing equipment 510 with gesture library.Gesture library may include the movement comprising gesture.Use this
Compare, data acquisition and processing equipment 510 can be estimated or determine whether to have made gesture.
In the posture and/or gesture for determining user 680, manikin can be with one or more epidermis electronic equipments
100 and data acquisition and processing equipment 510 be used in combination.Manikin can be the computer model of human motion and offer
Mode relative to the movement that all possible motion model inspection measures.Manikin may include human body link model, flesh
Meat skeleton model or other motion models.Human Modeling can be the rigid body with restriction shape of interconnection by human body link model
Group, these rigid bodies pass through the joint connection with the angle restriction limited.Document about these models includes: " Motion
Models for People Tracking”,David Fleet,Visual Analysis of Humans,Chapter 10,
Springer-Verlag(2011);" A 3-D Biomechanical Skeleton Model for Posture and
Movement Analysis”,Moreno D’Amico,et al,Research into Spinal Deformities 5,
IOS Press(2006).Rigid body, interconnection and the system in joint of the restriction can be used for based in one or more physical feelings
Azimuth sensing epidermis electronic equipment simulate posture and posture movements.The model can be it is general, or can for
People user carries out personalized.In some embodiments, adjusted using the measurement provided by epidermis electronic equipment 100 it is general or
Personalized model.Data acquisition and processing equipment manikin can be used assist in or estimate user 680 posture and/
Or gesture.For example, when determining or estimating the orientation of the point measured by epidermis electronic equipment 100, acceleration, movement, angular movement, rotation
Turn, angular speed, angular acceleration and/or when position, human body link model may be used as the constraint of sensor measurement and integral.One
In a little embodiments, further constraint includes the measured value of the additional sensor from such as inclinometer etc.From one
Or the measurement result of multiple inclinometers or magnetometer can be used for checking the orientation estimated by accelerometer.The technology is available
In the propagation of limitation mistake.In some embodiments, further constraint can also include epidermis electric room measured value.
With continued reference to Fig. 6, one or more external sensor devices 550 can be used in combination with epidermis electronic equipment 100.?
In some embodiments, external sensor device 550 is the equipment outside epidermis electronic equipment 100, for measuring orientation, accelerating
Degree, movement, angular movement, rotation, angular speed, angular acceleration and/or position.External sensor device 550 can be camera or movement
Capture imaging sensor.External sensor device 550 can be used for intermittently measuring to determine posture.For example, coming from external phase
The image of machine can be used for measuring the orientation of user 680, acceleration, movement, angular movement, rotation, angular speed, angular acceleration and/
Or position.In some embodiments, the measurement knot of the motion capture image sensor from actively or passively interactive device 780
Fruit is used to determine orientation, acceleration, movement, angular movement, rotation, angular speed, angular acceleration and/or the position of user 680.It comes from
The measurement result of one or more external sensor devices 550 can be used for resetting the determination based on epidermis electronic equipment 100.For example,
The measurement result obtained from external sensor device 550 can be used for calibrating the sensor of one or more epidermis electronic equipments 100.?
In some embodiments, the measurement result from external sensor device 550 can be used for updating or individual face body Model is to be used for
User 680.Manikin is also used as the calibration point of the sensor of one or more epidermis electronic equipments 100.Interactive device
780 can also calibrate in an identical manner.In some embodiments, external sensor device 550 is connected via communication connection 753
To data acquisition and processing equipment 510.External sensor device 550 may include communication equipment 750 to promote via communication connection
753 communication.In some embodiments, external sensor device 550 can connect via communication connection 753 and communication equipment 750
Connection control circuit 760.
In one embodiment, epidermis electronic equipment 100 using the field source of antenna and another position determine its relative to
The position of the another location and/or movement.Sensor 770 can be or including one or more antennas.For example, one or more
Antenna can be in dipole antenna, loop aerial, plate aerial, magnetometer, vector magnetometer and/or other kinds of antenna
It is one or more.One or more antennas can be used to measure field source in epidermis electronic equipment 100.Field source based on one or more
Measurement, epidermis electronic equipment 100 can estimate epidermis electronic equipment 100 relative to the position of field source, orientation, angular movement, rotation
Turn and/or other are moved.
Field source can be the source of any measurable field.For example, field source can be magnetic field sources, electromagnetic radiation (for example, microwave,
Radio wave etc.), and/or measurable field other sources.Field source can be microwave generator and/or antenna, transmitting set
And/or antenna or be configured to generates other combinations of the hardware of measurable field.In some embodiments, nature can be used
Magnetometer can be used to measure the magnetic field of the earth in field source, such as epidermis electronic equipment, and it is thus determined that one of its orientation or
Multiple angle components.Epidermis electronic equipment 100 may include the one or more for measuring the type of the field generated by field source
Antenna.Epidermis electronic equipment 100 may include the additional firmware for receiving and/or measuring one or more field sources.For example, table
Skin electronic equipment 100 may include receiver, signal processing hardware and/or other hardware.
In one embodiment, field source is emitted by the second epidermis electronic equipment 100.This can enable the first epidermis electronics to set
Standby 100 can determine that its relative to the position of the second epidermis electronic equipment 100 of transmitting field source, orientation, angular movement, rotation and/or
Other movements.Azimuth information can be sent to epidermis electronic equipment 100 from other positions, and it includes the information about field source, examples
Such as, the type of field source, space field mode, frequency, orientation etc..Field source can be interactive device 780 or be included in interactive device 780
In.In other embodiments, field source can be fixed.For example, field source can be the fixed launcher for generating field, it includes
One or more individually epidermis electronic equipments 100.When field source is fixed, one or more epidermis electronic equipments 100 can be surveyed
Measure individual absolute position, the orientation, angular movement relative to fixed field source, rotation and/or other movements.Fixing field source may include
In data acquisition and processing equipment 510 or another fixed equipment.In some embodiments, one or more epidermis electronics are set
Standby 100 can determine them relative to the position of other epidermis electronic equipments 100, orientation, rotation, angular movement and/or other fortune
It is dynamic.In some embodiments, epidermis electronic equipment can be by corresponding to other epidermis electronic equipments absolutely by relative information
To its absolute position of information combinational estimation, orientation, rotation, angular movement and/or other movements.
In one embodiment, epidermis electronic equipment 100 determines source using the range of range sensor and another position
Determine its position and/or orientation relative to another location (for example, second epidermis electronic equipment).Range sensor may include
One or more receivers are used to detect the range signal that source generation is determined by range.For example, range determines that source can be generated
Range signal including pulse ultrasonic wave or pulse electromagnetic wave.Range sensor (is supersonic detector or electromagnetic detection respectively
Device) it can detecte incidence wave, and it is based on arrival time, determine that range determines the range between source and range sensor.Individually
Range sensor can be used for detection range itself.However, in some embodiments, epidermis electronic equipment 100 include it is multiple away from
From sensor, and from range determining the difference range in source and determine that epidermis electronic equipment is true relative to range using each
Determine the orientation in source.Azimuth information can be sent to epidermis electronic equipment 100 from other positions, and it includes determine source about range
Information, such as pulse timing, wave frequency rate, emission mode, the orientation in source etc..It is, for example, possible to use two range sensors to determine
One angle component in direction, and three range sensors can be used for determining two angle components in direction.In an embodiment
In, range sensor and range determine that the effect in source can overturn;Here, epidermis electronic equipment 100 may include multiple (examples
Such as, 2 or 3) range determines source, and another position (for example, second epidermis electronic equipment) may include range sensor.
It can be used for determining the orientation of epidermis electronic equipment 100 by the difference range measurement that range sensor carries out.In some embodiments
In, epidermis electronic equipment 100 includes that one or more ranges determine both source and one or more range sensors, and use exists
Reflector (for example, diffusion, transmitting, retroeflection) at another position is to determine that source returns to distance and passes from range for range signal
Sensor, so that can determine that the range and/or orientation between epidermis electronic equipment 100 and other positions.
In a further embodiment, multiple fields can be used for measuring relative to multiple (fixed and/or mobile) field sources
Position, orientation, rotation, angular movement and/or other movements.For example, field source can have different timing or frequency, so that table
Skin electronic equipment 100 can distinguish multiple field sources.This can enable other technologies can be used to estimate one or more epidermis electronics
Position, rotation and/or other movements of equipment.Its position is carried out for example, multiple field sources can be used in epidermis electronic equipment 100
Triangulation.
In other above-mentioned embodiments, absolute and/or relative position, orientation, rotation, angular movement and/or other movements
Estimation can be calculated by one or more epidermis electronic equipments 100.It is, for example, possible to use set in one or more epidermis electronics
One or more control circuits on standby 100 execute calculating.Epidermis electronic equipment 100 can be used it is described herein a kind of or
Multiple technologies transmit information for these calculating.In other embodiments, calculating is executed far from epidermis electronic equipment 100.
For example, information (for example, situ measurements) can be transmitted to by one or more epidermis electronic equipments 100 can execute this paper
The data acquisition and processing equipment 510 of the calculating.
Referring still to Fig. 6, address, position, orientation, rotation and/or other measurements moved and/or estimation can be used for executing
Various movements and/or further calculating.Orientation, movement and/or position may be used as controlling one or more interactive devices 780
Parameter.For example, orientation, movement or position can be used for controlling delivery system.If user 680 lies down (for example, by table
Skin electronic equipment 100 and/or data acquisition and processing equipment 510 determine), then it can indicate that delivery system does not deliver analgesic
Medicine.On the contrary, can be referred to by data acquisition and processing equipment 510 and/or control circuit 760 if user 680 is moving
Show delivery system to apply anodyne.
By measuring orientation, acceleration, movement, angular movement, rotation, angular speed, angle acceleration after triggering interactive device
The variation of degree and/or position and/or aforementioned item, can measure the influence of interaction.This is also possible that can calibrate interaction sets
Standby 780.It, can be with for example, if the parameter posture of user 680 (for example, during movement) measured does not show improvement
The drug of larger dose is used when activating interactive device 780 next time.
In addition, orientation, movement and/or position can be used for controlling sensor 770.For example, if user is in position of lying down
It sets, then it can be with closure sensor 770 and/or interactive device 780 to save power.In some embodiments, described herein
Any parameter (for example, orientation, posture, acceleration etc.) may be used as the basis of alarm.When some or multiple parameters are more than threshold value
When, epidermis electronic equipment 100 can provide alarm.For example, if detecting the quick acceleration in the event of such as traffic accident etc,
The LED in surface electronics can be then illuminated, or is illuminated with corresponding to the particular color of seriousness, it can to alert observer
The injury of energy.Such configuration can also be used in other settings (for example, physiotherapy).In some embodiments,
Alarm is provided by data acquisition and processing equipment 510.Data acquisition and processing equipment 510 can be used display and provide alarm.
Data acquisition and processing equipment 510 can provide alarm (for example, to mobile computing device or phone to another equipment or computer
There is provided alarm).
Orientation is measured referring now to Figure 7, showing according to an embodiment using one or more epidermis electronic equipments
Method 810.The orientation on the surface attached by surface electronics and/or the data (812) of angular movement are provided.This can be with
It is realized by any combination of previously described sensor.Then collecting sensor data (814).For example, control circuit can
With collection/acquisition data.Control circuit can collect in part with multiplexer/obtain data.In some embodiment party
In case, unit auxiliary multiplexing.In some embodiments, sensing data is then delivered to data acquisition and processing is set
It is standby.The combination of control circuit and communication equipment can be used to complete in this.Algorithm is applied to sensing data (816).One
In a little embodiments, data acquisition and processing equipment apply the algorithm.In other embodiments, control circuit applies the calculation
Method.One or more algorithms can be used, and algorithm can perform various functions.It makes an uproar for example, algorithm can be used for reducing signal
Sound eliminates extraneous data point, generates the constraint etc. for calculating the orientation and/or position of surfaces for attachment.Used algorithm can
Including Kalman filter, kinetic filter or other customized filters.Estimation calculates surfaces for attachment and/or epidermis electronics
The orientation of equipment, movement, rotation and/or position (818).In some embodiments, data acquisition and processing equipment use biography
Orientation, movement, rotation and/or the position of surfaces for attachment and/or epidermis electronic equipment are estimated or are calculated in sensor data and/or constraint
It sets.In other embodiments, control circuit using sensing data and/or constraint come estimate or calculate surfaces for attachment and/or
Orientation, movement, rotation and/or the position of epidermis electronic equipment.In a further embodiment, it is also calculated using one or more
Method executes calculating.In addition to or other than replacing orientation, rotation and/or the position of surfaces for attachment and/or epidermis electronic equipment, may be used also
To estimate posture.In some embodiments, the position, orientation of physical feeling, movement and/or rotation can refer to physical feeling
In/on from surfaces for attachment and therefore be different from the different position in the position of epidermis electronic equipment 100 (for example, the ginseng of forearm
The midpoint that position can be located at radius is examined, and surfaces for attachment is located on the crust surface near wrist;In this case, two
Position, orientation, movement and the rotation of position can be different due to direct acting offset.It calculates executing these (for example, really
Orientation or posture) when, the constraint or inspection generated from other sources can be used in data acquisition and processing equipment.For example, constraint
Algorithm, additional sensor (such as inclinometer) and/or external sensor device (such as motion capture image sensor) can be passed through
It provides.After estimating or calculating orientation, rotation, movement and/or the position of surfaces for attachment, epidermis electronic equipment can be by making
Circulation is started again at sensor, to generate the orientation on the surface attached by epidermis electronic equipment and/or the data of rotation.
In some embodiments, step (812)-(818) execute in data pipeline operation simultaneously.For example, when first group of data
When for computer azimuth, algorithm can be used, second group is filtered, third group can be collected by control circuit, and can be with
The 4th group is generated by sensor.
While next step circulation, additional move can be taken.In some embodiments, in next step
Circulation takes additional move before starting.It, can school after estimating or calculating orientation, rotation and/or the position of surfaces for attachment
Quasi- sensor and/or interactive device (820).Data acquisition and processing equipment, which can determine, needs to calibrate sensor and/or interaction
Equipment.Using the data of the other sensors on epidermis electronic equipment, the data from external sensor device, model and/
Or calculated constraint, data acquisition and processing equipment combination control circuit can calibrate sensor or interactive device.Some
In embodiment, calibration is only completed by control circuit.Data acquisition and processing (DAP) equipment can be covered and be run by processing circuit
Predetermined calibration algorithm.Other than calibration sensor and/or interactive device and/or control interactive device, or individually, also
It can store various types of data (822).In some embodiments, data are stored by data acquisition and processing equipment.?
In other embodiments, data are stored by control circuit.Data are stored locally in data acquisition and processing equipment, or
It can be for transmission to other computer, display equipment, mobile device etc..In some embodiments, storage result and/or only one
Partial data.In some embodiments, interim storing data allows equipment to show the figure table of data and/or data
Show.Other than calibration sensor and/or interactive device and/or storing data, or individually, one or more can also be controlled
A interactive device (824).Data acquisition and processing (DAP) equipment combination control circuit can activate one or more interactive devices.Example
Such as, in the particular orientation for determining user, data acquisition facility and control circuit can activate interactive device to deliver drug.?
In some embodiments, interactive device is controlled by control circuit, without the input from data acquisition and processing equipment.
Referring now to Figure 8, showing the operating method 900 of epidermis electronic equipment according to an embodiment.It is attached epidermis electricity
Sub- equipment (902).Epidermis electronic equipment is attached to surfaces for attachment 103, and surfaces for attachment 103 may include skin, bone, muscle groups
It knits, heart, lung etc..In some embodiments, surfaces for attachment 103 is attachment or will be attached to the taut of skin or other organs
Band.It obtains sensing data (904).Obtaining sensing data may include the one or more parameters for measuring surfaces for attachment 103.
In some embodiments, the sensor 770 in epidermis electronic equipment 100 measures one or more parameters of surfaces for attachment 103.
For example, the orientation by the electronic device layer 107 in epidermis electronic equipment 100 that sensor 770 can measure surfaces for attachment 103 is forced
Close orientation.Sensor 770 can also measure the orientation of surfaces for attachment 103, acceleration, movement, angular movement, rotation, angular speed,
Angular acceleration and/or the rate of change of position.In some embodiments, pass through control circuit 760 or data acquisition and processing
The rate of change of these parameters of the calculating of equipment 510.Collecting sensor data (906).For example, sensing data is received by control circuit
Collection.The multiplexer 765 in control circuit 760 can be used to complete in this.It handles data (908).For example, control circuit
760 can be used processor 763 and memory 761 to calculate the orientation of epidermis electronic equipment 100.Various technical offices can be passed through
Reason data are accelerated with orientation, acceleration, movement, angular movement, rotation, angular speed, the angle of estimating or calculate epidermis electronic equipment 100
Degree and/or position.For example, control circuit 760 Kalman filter, kinetic filter or other algorithms can be used calculating or
Estimate the orientation of epidermis electronic equipment 100.Control circuit 760 can also be expert at using constraint in calculating, such as from epidermis electricity
The data of other sensors 770 in sub- equipment 100, come from external sensing at the data from another epidermis electronic equipment 100
The data and/or model of equipment 550.Control circuit 760 can also monitor sensor 770 irregularly to be measured.
After obtaining and handling data, show data (922).In some embodiments, control circuit 760 is by data
Data acquisition and processing equipment 510 are sent to be shown.In other embodiments, data acquisition and processing equipment 510
Show data.The data of display can be original sensor data, constraint, model, processed data, the estimation of surfaces for attachment
Orientation, acceleration, movement, angular movement, rotation, angular speed, angular acceleration and/or position, position, orientation, gait and/or appearance
One of graphical representation of gesture etc. or combinations thereof.In some embodiments, data are shown in another computer or equipment (number
Relevant information is sent to it with processing equipment 510 according to obtaining) on.Method 900 can pass through the biography using epidermis electronic equipment 100
Sensor 770 measures one or more parameters to start again at.In some embodiments, it is carried out several times before showing data
Iteration.In some embodiments, the iteration of a step only occurs.
In some embodiments, control signal (910) is sent after control circuit 760 handles data.Control signal
Sensor 770 and/or interactive device 780 can be sent to.In the case where control signal is sent to sensor 770, control
Sensor 770 (912) processed.This may include calibration sensor 770.This can also include opening or closing sensor 770.It is controlling
In the case that signal processed is sent to interactive device 780, control interactive device 780 (914).This may include activation interactive device
780, for example, to convey drug with medicament delivery device.Control interactive device 780 can also include opening or closing interactive device
780.After control sensor 770 or control interactive device 780, this method can be by utilizing epidermis electronic equipment 100
Sensor 770 measures one or more parameters to start again at.
In some embodiments, control circuit 760 uses communication equipment 750 and communication after data have been processed
Connect 753 output datas.In other embodiments, the possible previously not processed mistake of the data of output is (for example, control circuit
760 can export measurement data from sensor 770 in the case where no estimation or calculating direction).It can output data to
Data acquisition and processing equipment 510.In some embodiments, other equipment are output data to.For example, data can export
To other epidermis electronic equipments 100 or it is output to computer in addition to data acquisition and processing equipment 510.Available and place
Manage the data of output.In some embodiments, data are obtained and are handled by data acquisition and processing equipment 510.Data acquisition
Data can be obtained using epidermis electronic equipment 100 by communication equipment 750 and communication connection 753 with processing equipment 510.Data
Orientation, acceleration, movement, angular movement, rotation, angular speed, the angle for estimating or calculating epidermis electronic equipment 100 can be passed through
The various technologies of acceleration and/or position are handled.For example, Kalman filtering can be used in data acquisition and processing equipment 510
Device, kinetic filter or other algorithms calculate or estimate the orientation of epidermis electronic equipment 100.Data acquisition and processing equipment
510 can also when being calculated using constraint, such as the other sensors 770 in epidermis electronic equipment 100 data,
Data from another epidermis electronic equipment 100, data and/or model from external sensor device 550.Further
In embodiment, it can be sent out after obtaining data from sensor 770 and handling data by data acquisition and processing equipment 510
Send control signal.Data acquisition and processing equipment 510 can send control signal after obtaining and handling data.Control signal
Communication equipment 750 can be used and communication connection 753 is sent to control circuit 760.In some embodiments, control circuit
760 send control signal using the data of transmission or information, as indicated by data acquisition and processing equipment 510.Control electricity
The calculating that road 760 is also based on control circuit 760 sends control signals to one or more interactive devices 780 and/or one
A or multiple sensors 770.For example, control circuit 760 can detected unrelated (extraneous) by control circuit 760
Sensor 770 is sent to be corrected by calibration control signal after measurement result.
It should be noted that can make although Fig. 7-8 provides the various examples of operation epidermis electronic equipment 100
With other steps and/or component, and all such embodiments are within the scope of this disclosure.For example, using epidermis electricity
The method 810 of sub- equipment 100 may include other step or component.Sensor 770 can produce about orientation, acceleration,
The number of the characteristic (for example, humidity) of movement, angular movement, rotation, angular speed, angular acceleration and/or position or any other measurement
According to.In some embodiments, unit 120 executes the function of multiplexing sensor output.In this case, control circuit
760 function can be executed by unit 120 and/or data acquisition and processing equipment 510.In some embodiments, data obtain
It takes and is executed with the function of processing equipment 510 by control circuit 760.For example, control circuit 760 can be configured as algorithm application
In sensing data and estimation or the orientation, rotation and/or the position that calculate surfaces for attachment 103.In another example, epidermis electronics
The operating method 900 of equipment may include other step or component.Each step of method 900 can be (for example, such as in flowing water
In line operation) it is performed simultaneously.Other steps and component can with it is disclosed about component and its function and table in figures 7 and 8
The disclosure of the function of skin electronic equipment is consistently used in method shown in Fig. 7 and 8.
It also describes for monitoring repeated stress damage and arthritic system and method.Repeated stress damage may
Including due to repeating and strong body kinematics or vibration and the physical feeling harmful position continuous positioning in biomethanics
The damage of caused tendon, nerve and other soft tissues, and may be with the numbness of muscle, pain and syntexis and the table that dies down
Sign.These system and method include from the one or more biosensors and motion-sensing being located near subject's physical feeling
Device generates sensing signal.In one embodiment, system and method described herein can be used for by from being configured as monitoring
The one or more of one or more physiological status of subject and one or more movements of subject's physical feeling or position
Biosensor and motion sensor generate sensing signal to monitor and treat medical conditions, and pass through one or more effectors
Effect to physical feeling provide effect.Medical conditions may include but be not limited to the noninflammatory illness based on joint (for example, joint
Bitterly, osteoarthritis), inflammatory disorders based on joint are (for example, rheumatoid arthritis, psoriasis arthropathica, arthritis, strong
Straightforward rachitis, Juvenile idiopathic arthritis and systemic loupus erythematosus), the illness based on start-stop point is (for example, start-stop point
It is scorching), the illness (for example, myotenositis, tenosynovitis) based on tendon, the illness based on ligament (for example, strain), be based on Nerve entrapments
Or stress disorder or syndrome are (for example, wrist is restricted and suppress by means of administrative decrees, etc., elbow is restricted and suppress by means of administrative decrees, etc., shank is restricted and suppress by means of administrative decrees, etc., nervus radialis card pressure, cacesthesia stock
Bitterly) etc..(a kind of wrist restrict and suppress by means of administrative decrees, etc.) is related to median nerve and is pressed when it enters wrist by canalis carpi for example, carpal tunnel syndrome
Compel, and may be related (see, e.g., Palmer, Best Pract Res Clin Rheumatol.Feb with occupational factor
2011;25 (1): 15-29, be incorporated herein by reference).
In one embodiment, system and method described herein is tested to monitor using one or more biosensors
One or more physiological status of person simultaneously generate sensing signal in response to this.Biosensor includes but is not limited to electromyogram graphy
Device, strain transducer, temperature sensor, optical sensor (for example, LED) and acoustic sensor.
In one embodiment, system and method described herein is tested to monitor using one or more motion sensors
The movements of parts of the body of person or position, and sensing signal is generated in response to this.Motion sensor includes but is not limited to be configured
For measure physical feeling repeating motion sensor, be configured as measurement movements of parts of the body number of repetition sensing
Device, the sensor for being configured as the speed that measurement physical feeling moves, the duration for being configured as measurement physical feeling movement
Sensor, be configured as measurement physical feeling relative to the arrangement of the second physical feeling sensor and be configured as surveying
Measure the sensor of movements of parts of the body angle.
In one embodiment, system and method described herein is using one or more effectors come in response to sensing
Device assembly generate sensing signal processing and influence physical feeling.Effector include but is not limited to tactile stimulator (for example, by
Be configured to provide for the position about physical feeling tactile instruction tactile stimulator) and nerve stimulator (for example, being configured as
There is provided the nerve stimulator of the treatment stimulation or resistance plug to nerve conduction).
In one embodiment, as shown in figure 9, system 1000 is configured as monitoring and treating and repeated stress damage phase
Medical conditions, arthritis or other medical conditions of pass.System 1000 includes substrate 1002, sensor module 1004, processor
1006 and effector 1008.In one embodiment, system 1000 include epidermis electronic system (EES) with monitor for monitoring,
Prevent and treat physiology, position and the fortune of medical conditions relevant to repeated stress damage, arthritis or other medical conditions
Dynamic situation.EES describes electronic system classification, which provides the thickness for being suitable for engaging with skin surface, has
Imitate elasticity modulus and flexibility (see, e.g., Kim et al., Epidermal Electronics, Science,
Vol.333,838-843 (2011) and Yeo et al., Multifunctional Epidermal Electronics
Printed Directly Onto the Skin, Advanced Materials Vol.25 (20), 2773-2778 (2013),
It is incorporated herein by reference) and may include sensor (for example, physiology, temperature, strain transducer) and interlock circuit (example
Such as, transistor, diode, photodetector, RF component, capacitor, oscillator).
Substrate 1002 is deformable (for example, flexible, stretchable) substrate, is configured to the skin table with subject
Face bonding.The deformable nature of substrate 1002 promotes interaction/engagement with skin surface, and skin surface is usually low modulus
With deformable natural surface.For example, substrate 1002 may include elastomer polymer, hydrocolloid film, nanometer film (for example, silicon is received
Rice film) or one of other deformable materials or a variety of.For example, substrate 1002 may include one or more coatings.According to each
Kind mechanism, substrate 1002 can be positioned near skin surface, are including but not limited to fixed on skin by jointing material, and
It is held in place by external pressure, the external pressure is for example by the material of winding physical feeling (for example, fabric, clothes
Deng) provide pressure.In one embodiment, substrate 1002 is configured as reversibly deforming to be equipped with base with physical feeling
The compatibility of deformation of the skin surface of plate 1002.In one embodiment, substrate 1002 includes being configured to engage with skin surface
Breathable elastomeric piece, the electronic component of EES reside in the breathable elastomeric on piece (see, for example, Kim et al.,
It is incorporated herein by reference).In one embodiment, substrate 1002 include limited by opposite structural resiliency structure base board it is micro-
Fluid enclosure, the electronic component of EES is between opposite structural resiliency structure base board (see, for example, Xu et al, Soft
Microfluidic Assemblies of Sensors,Circuits,and Radios for the Skin,Science,
Vol.344,70-74 (2014), are incorporated herein by reference).
Substrate 1002 may be configured to interact with the skin surface of particular body portion.In exemplary embodiment
In, physical feeling includes finger, hand, wrist, toe, foot, ankle, arm, ancon, leg, knee, shoulder, hip, vertebral part
Position (for example, close to region of one or more of cervical vertebra, thoracic vertebrae, lumbar vertebrae, sacrum backbone and tail bone), flank position are (for example, close
The region of rib cage, such as the position of rib cage attachment backbone), trunk, one in neck and head zone (for example, face, scalp)
Person or more persons.For example, substrate 1002 can meet tubular structure with promote with the interaction of finger or toe (see, e.g.,
Ying et al.,Silicon nanomembranes for fingertip electronics,Nanotechnology,
Vol.23, No.34,1-7 (2012), are incorporated herein by reference).In one embodiment, as shown in Figure 10, system 1000
It is located in the wrist 1100 of subject, for monitoring, preventing and treating with wrist or against other physical feelings of wrist
(including but not limited to hand, one or more fingers and arm) relevant medical conditions relevant to repeated stress damage, pass
Section inflammation or other medical conditions.
Referring to Fig. 9-14, sensor module 1004 includes motion sensor 1010 and biosensor 1012.Sensor group
Part 1004 is configured as based on motion sensor 1010 to the detection of movements of parts of the body and biosensor 1012 to body
The detection of the physiological parameter at position generates one or more sensing signals.In one embodiment, motion sensor 1010 wraps
Include one or more of accelerometer (for example, accelerometer 1400) and proximity sensor (for example, proximity sensor 1402)
To detect movements of parts of the body and generate sensing signal in response to this.Proximity sensor may include infrared sensor (for example, red
One or more of outer sensor 1404) and optical sensor (for example, optical sensor 1406).In one embodiment,
Proximity sensor is configured as sensing the second physical feeling close to the physical feeling where system 1000.For example, system 1000
It can be positioned in the wrist of subject, and motion sensor 1010 may include proximity sensor, the proximity sensor quilt
It is configured to detect presence, the position, angle of another physical feeling (such as hand, palm, arm, finger, shoulder etc.) close to wrist
One of degree and movement or more persons.In one embodiment, proximity sensor is configured as sensing another with skin surface
A part or the equipment engaged with another physical feeling.For example, system 1000 can be positioned in the physical feeling of subject, and
And second system 1000 is located in physical feeling nearby or is located in another physical feeling, wherein the movement of system 1000 passes
The proximity sensor of sensor 1010 can sense one of presence, position, angle and movement of second system 1000 or more
Person.
Motion sensor 1010 is configured as one or more in the position of detection movements of parts of the body and physical feeling
It is a.Physical feeling can be the position engaged with system 1000, or can be the close portion in the position engaged with system 1000
Position.In one embodiment, motion sensor 1010 generates sensing signal based on the repeating motion of physical feeling.For example, system
1000 can be positioned in the wrist of subject, and motion sensor 1010 measures the repetition bending or bending of wrist, such as
To move hand or one or more fingers.In one embodiment, motion sensor 1010 measures the weight of movements of parts of the body
Again it counts.For example, system 1000 can be positioned on the finger of subject, and the measurement of motion sensor 1010 specific finger is curved
Folding or curved number of repetition.Measurement number of repetition may include but be not limited to measurement and zero repetition occurred, and measure limited repetition time
Number measures duplicate number at the appointed time section, and determines that number of repetition is more than threshold number (for example, there is subject
The threshold value of the risk of repeated strain Damage).In one embodiment, motion sensor 1010 measures movements of parts of the body speed
Degree.For example, system 1000 can be positioned on the ankle of subject, and motion sensor 1010 measures the movement speed of ankle
Degree, for example, during walking movement during ankle flexion the movement velocity of ankle, during walking movement relative to ground
One or more of movement velocity or the movement velocity during other movements.In one embodiment, motion sensor
1010 measurement movements of parts of the body duration.Duration may include total exercise duration (example in a period of time
One or more of such as, comprising the duration moved is repeated several times) and total exercise duration of single repeating motion.Example
Such as, system 1000 can be positioned on the finger of subject, and motion sensor 1010 measurement whithin a period of time bending or
The duration and finger for being bent the movement of finger for example hold relative to the duplicate movement of the single of the movement of palm, hand or wrist
One or more of continuous time.The period of measurement movement can include but is not limited to tested in 1 minute, 1 hour, 1 day
Person is awake and part when enlivening, 1 day or longer duration.In one embodiment, sensor module 1004 is matched
It is set to the arrangement for measuring physical feeling whithin a period of time.For example, in physical feeling is in static, in movement, and
It is maintained at while be not one or more of resting position (for example, tense) position, sensor module 1004 can be with
The arrangement of time passage measurement physical feeling.In one embodiment, the measurement of motion sensor 1010 is at 1000 place of system
Physical feeling is relative to the second physical feeling during the movement of one or more of physical feeling and the second physical feeling
Arrangement.For example, system 1000 can be positioned on the phalanx of subject, and motion sensor 1010 measure phalanx relative to by
Arrangement of the wrist or ankle of examination person during phalanx or the movement of wrist/ankle.In one embodiment, motion sensor 1010 is surveyed
Measure movements of parts of the body angle.For example, system 1000 can be positioned on the arm of subject, and motion sensor 1010
Measure arm (for example, relative to trunk, relative to the resting position of arm, relative to another physical feeling etc.) movement angle
Degree.The repeating motion of physical feeling, the number of repetition of movements of parts of the body, physical feeling are measured by motion sensor 1010
Arrangement relative to the second physical feeling of the speed of movement, the duration of movements of parts of the body, physical feeling, Yi Jishen
One or more information provided in the movement angle of body region can determine whether subject has weight with help system 1000
Renaturation stress damage or risk with the presence or absence of repeated stress damage, and can provide about for by system 1000
Treat or avoid the data of the movement of specific repeated stress damage.
Biosensor 1012 is configured as the physiological parameter of the subject where detection system 1000.In an embodiment
In, biosensor 1012 detects the body by the physical feeling and the close position engaged with system 1000 that engage with system 1000
One or more local physiological parameters provided in body region.Biosensor 1012 can be additionally configured to detection system
The systemic physiological parameter of subject where 1000.In one embodiment, biosensor 1012 includes electromyograph
(EMG) (Figure 13 shows electromyograph 1408), such as sensor electrode are configured to monitor close to 1000 place of system
The bioelectrical activity of the musculature of physical feeling.In one embodiment, biosensor 1012 includes strain transducer (example
Such as, strain transducer 1410).For example, strain transducer can be the sensor based on silicon nanometer film, it is located at skin surface
On, to measure the physiological parameter based on strain (see, e.g., Son et al., Multifunctional wearable
devices for diagnosis and therapy of movement disorders,Nature
Nanotechnology, Vol.9,397-404 (2014) are incorporated herein by reference herein).In one embodiment, physiology
Sensor 1012 includes temperature sensor (for example, temperature sensor 1412).For example, temperature sensor can include but is not limited to
Single point temperature sensor, aerial image temperature sensor, and it is configured to the Miniature temperature biography of micro-heating element or actuator
Sensor, such as one or more micro temperature sensors comprising the thin snakelike feature of thin metal or the PIN with nanoscale film
Diode is (see, e.g., Webb et al., Ultrathin conformal devices for precise and
continuous thermal characterization of human skin,Nature Materials,Vol.12,
938-944 (2013), is incorporated herein by reference).In one embodiment, biosensor 1012 includes optical sensor
(for example, optical sensor 1414) is configured to the optical characteristics of the physical feeling where measuring system 1000.For example, optics
Sensor can include but is not limited to light emitting diode (LED) (for example, light emitting diode 1416), and LED and photoelectric sensor are assisted
It adjusts, imaging device, such as camera, etc..In one embodiment, biosensor 1012 includes acoustic sensor (for example, sound
Learn sensor 1418).Acoustic sensor can provide the data about joint motions, joint include but is not limited to wrist, ancon,
Shoulder, ankle, knee and buttocks.
Processor 1006 is configured as receiving one or more sensing signals from sensor module 1004 and handles sensing letter
Number, to provide control signal to the part of system 1000, such as is provided to effector 1008 and control signal.In an embodiment
In, processor 1006 is coupled to the resident part of appliance of substrate 1002.Optionally, processor 1006 can be located remotely from substrate
1002 position, and can be sent and received signal by relevant wireless communications method, the signal includes but is not limited to
Acoustic communication signal, optical communication signal, radiocommunication signals, Infrared communications signals, ultrasonic communication signal etc..Processor
1006 may include microprocessor, central processing unit (CPU), digital signal processor (DSP), specific integrated circuit (ASIC),
Field programmable gate entrance (FPGA) etc., or any combination thereof, and may include discrete number or analog circuit element or electricity
Sub- equipment, or combinations thereof.In one embodiment, calculating equipment includes having the one or more of multiple predefined logical blocks
ASIC.In one embodiment, calculating equipment includes one or more FPGA with multiple programmable logic orders.
Effector 1008 is operatively coupled to processor 1006 and in response to processor 1006 to one in following item
Or multinomial control and influence physical feeling: prevent and treat and repeated stress damage, arthritis or other medical conditions
Relevant medical conditions.In one embodiment, effector 1008 include tactile stimulator (for example, tactile stimulator 1420) and
One or more of nerve stimulator (for example, nerve stimulator 1422).Tactile stimulator can to subject provide about
The instruction of the position of physical feeling.For example, sensor module 1004 can be generated about the physical feeling where system 1000
One or more sensing signals of position, wherein processor 1006 receives sensing signal and indicates effector 1008 (for example, tactile
Stimulator) instruction about position is provided a user, such as realized by providing a user vibratory response.In an embodiment
In, processor 1006 determines that the position of physical feeling is harmful position in biomethanics.For example, processor 1006 can will be by
One or more sensing signals that sensor module 1004 generates are stored in answering in resident or remote memory storage devices with expression
The reference data of loss on transmission wound is compared.Then, processor 1006 can indicate tactile stimulator (such as by provide vibration effect
Fruit) physical feeling is influenced, it is instruction as biomethanics nocuousness position to provide the position of physical feeling.In an embodiment
In, processor 1006 determines that physical feeling has kept current location to last longer than threshold duration.For example, processor
1006 can be by one of the duration about physical feeling in specific position generated by sensor module 1004 or more
A sensing signal is compared with the threshold duration being stored in resident or remote memory storage devices.Threshold duration can
Based on the biomechanical data for indicating when the repeated stress damage of possible generation.Then, processor 1006 can indicate to touch
Feel that stimulator (such as by providing vibrating effect) influences physical feeling, has kept current location to continue to provide physical feeling
Time is longer than the instruction of threshold duration.
Effector 1008 may include nerve stimulator, be configured as into the subject where system 1000 one or
Multiple nerves provide electro photoluminescence.In one embodiment, nerve stimulator generates electric current or pulse is close therapeutically to stimulate
The nerve of physical feeling where system 1000.Treating stimulation can be used for treating or avoiding the repeated stress damage of subject.
In one embodiment, nerve stimulator is configured as that the nerve of the nerve close to the physical feeling where system 1000 is stimulated to pass
It leads.Stimulation nerve conduction causes the feeling of movements of parts of the body or physical feeling.For example, sensor module 1004 is based on movement
Sensor 1010 is to the detection of movements of parts of the body or position and biosensor 1012 to the physiological parameter of physical feeling
Detection and generate one or more sensing signals, wherein processor 1006 receives one or more sensing signals and indicates effect
Device 1008 stimulates the nerve conduction of the nerve close to the physical feeling where system 1000 by generating electric current or pulse, thus
Cause movements of parts of the body or causes the feeling to influence physical feeling of physical feeling.In one embodiment, nerve stimulation
Device is configured to stimulate nerve conduction after physical feeling is maintained at the specific position duration threshold period.For example, motion-sensing
Device 1010 can provide one or more sensing signals of the position about physical feeling during of short duration lasting.When one
Or multiple sensing signals correspond to threshold duration of short duration lasting period period in do not deviate significantly from when, be
System 1000 can be inferred that physical feeling is maintained in specific position.Threshold duration can correspond to physical feeling and be answered
Become damage risk or strain Damage risk increased time.
In one embodiment, nerve stimulator is configured as power block close to the mind of the physical feeling where system 1000
The nerve conduction of warp.For example, nerve stimulator generates electric current or pulse to interfere the nerve conduction of nerve, the nerve of block nerves
Conduction, the nerve conduction for changing nerve etc..Block nerves conduct the nociceptor that can inhibit subject.For example, being based on
Motion sensor 1010 is to the detection of movements of parts of the body and biosensor 1012 to the physiological parameter of physical feeling
It detects and generates one or more sensing signals, wherein processor 1006 receives one or more sensing signals and indicates effector
1008 stop the nerve conduction of the nerve close to the physical feeling where system 1000 by generating electric current or pulse, to press down
The feeling of pain of subject processed influences physical feeling.In one embodiment, stop nerve conduction that can inhibit physical feeling
Movement.For example, generating in sensor module 1004 indicates that physical feeling is maintained at one or more of biomethanics nocuousness position
In the case where a sensing signal, processor 1006 can control effector 1008 to stop the nerve of the nerve close to physical feeling
Conduction is to inhibit movements of parts of the body, to avoid keeping and being repositioned onto biomethanics nocuousness position.For inhibiting
Other indicators of physical feeling movement including but not limited to indicate the repeating motion of repeated stress damage, protect physical feeling
Hold is being more than the position etc. of threshold duration.
In one embodiment, as shown in figure 11, system 1000 includes power supply 1200, is configured as to system 1000
One or more components provide power, including but not limited to mention to sensor module 1004, processor 1006 and effector 1008
For power.In one embodiment, power supply 1200 is coupled to the resident part of appliance of substrate 1002.Resident part of appliance shows
Example includes but is not limited to battery (for example, hull cell) and is configured to convert light energy into electric energy for the component of system 1000
The solar battery (for example, solar battery based on silicon) used.In one embodiment, power supply 1200 includes far from substrate
One or more components of 1002 positioning, pass through relevant wireless power method power signals, the wireless power method
Including but not limited to power signal is inductively.In such embodiments, system 1000 includes being located in substrate 1002
On one or more components, the component is configured as executing one or more of following operation: receiving, processing and distribution
Power signal from the component positioned far from substrate 1002.For example, system 1000 may include being coupled to the nothing of substrate 1002
Linear heat generation rate coil, be configured as receive remote power signal, for example originating from remote transmission coil remote power signal (referring to
Such as Kim et al., it is incorporated herein by reference).
In one embodiment, as shown in figure 12, system 1000 includes the comparison module that can be accessed by processor 1006
1300, by the movements of parts of the body detected by the motion sensor 1010 of sensor module 1004 and by sensor module
The physiological parameter for the physical feeling that 1004 biosensor 1012 detects is compared with the reference data for indicating strain Damage.?
In one embodiment, processor 1006 accesses comparison module 1300, computer storage by access computer storage 1302
Device 1302 can include but is not limited to random access memory (RAM), read-only memory (ROM), and electrically erasable is read-only
Memory (EEPROM), flash memory or other memory technologies, CD-ROM, digital versatile disc (DVD) or other disc memories,
Cassette, tape, magnetic disk storage or other magnetic storage apparatus or any other can be used for store tieed up by comparison module 1300
The medium of information needed that is protecting and being accessed by processor 1006 or other access equipments.Reference data can be by system
1000 computer storage 1302 stores, can be by processor 1006 via radio apparatus access, or can be by another
Kind method can be used for processor 1006.Reference data may include physiology related with acute or traumatic damage and biomethanics
Information, described acute or traumatic damage include but is not limited to muscle or soft tissue (for example, ligament, tendon, prosthese or other knots
Form tissue) strain, strain or tearing.Reference data may include physiology related with long-term or chronic medical illness and biology
Mechanical information, the long-term or chronic medical illness
It may include but be not limited to noninflammatory illness (for example, arthralgia, osteoarthritis), the inflammation based on joint based on joint
Disease illness is (for example, rheumatoid arthritis, psoriasis arthropathica, arthritis, ankylosing spondylitis, adolescent idiopathic close
Section is scorching and systemic loupus erythematosus), the illness (for example, enthesitis) based on start-stop point, the illness based on tendon is (for example, flesh
Tendonitis, tenosynovitis), the illness (for example, chronic strain) based on ligament, based on Nerve entrapments or stress disorder or syndrome (example
Such as, wrist is restricted and suppress by means of administrative decrees, etc., elbow is restricted and suppress by means of administrative decrees, etc., shank is restricted and suppress by means of administrative decrees, etc., nervus radialis card pressure, meralgia paraesthetica) etc..
By realizing the agreement of comparison module 1300, processor 1006 can be by obtained by sensor module 1004 and body
The related movement in position, position and physiological data are compared with the reference data for indicating strain Damage, and carry out related body
The determination of the risk or possibility of strain Damage occurs for position.In one embodiment, processor 1006 is also based on from sensor
The received data of component 1004 determine the movement to be executed by effector 1008 compared between reference data.For example,
In the case that processor 1006 determines that physical feeling is in the opposite high risk for causing strain Damage, processor 1006 be can control
Effector 1008 is taken the first movement (for example, electric effect nerve conduction), and if processor 1006 determines at physical feeling
In cause strain injure relatively low-risk in, then processor 1006 can control effector 1008 take the second movement (for example, to
Subject provides the visible, sense of hearing or tactile alert).
In one embodiment, as shown in figure 14, system 1000 further includes being configured as transmitting information from system 1000
Reporter 1500.Information from reporter 1500 can by visual means (for example, visual information), audible mode (for example,
Auditory information) and as one of data (for example, one or more data-signal associated with the information to be transmitted)
Or a variety of offers.In one embodiment, reporter 1500 reports the actuating of effector 1008, the physical feeling detected
Movement or one or more of position and the physiological status detected.Reporter 1500 can be provided about physical feeling
Movement, the warning or instruction of position and physiological status.For example, reporter 1500 can be configured as the life reported to physical feeling
The warning of the risk of the harmful positioning of material resources.It is harmful in biomethanics to position the risk (example that will affect repeated strain Damage
Such as, it is determined by the processor 1006 of realization comparison module 1300).In one embodiment, reporter 1500 is configured as reporting
Accuse the instruction at position of moving.Reporter 1500 can be combined with effector 1008 and be worked, to act in effector 1008
When, such as when haptic stimulus occurs by the tactile stimulator of effector 1008, vision or acoustic background are provided to subject.
In one embodiment, reporter 1500 includes display 1502, is configured as believing using system 1000 to subjects reported
Breath, transmission information otherwise provide information.Display 1502 can include but is not limited to graphic user interface (GUI),
Touch panel unit (for example, capacitive touch screen), liquid crystal display (LCD), light emitting diode (LED) display and based on projection
Display.In one embodiment, reporter 1500 includes transmitter 1504, is configured as sending out information from system 1000
It is sent to remote location 1506 (for example, remote entity, remote equipment etc.).In one embodiment, remote location includes that communication is set
It is standby, such as one or more of mobile communication equipment and computer system comprising but it is not limited to mobile computing device (example
Such as, hand-portable computers, personal digital assistant (PDA), portable computer, netbook computer, tablet computer
Deng), mobile telephone equipment (for example, cellular phone and smart phone) including with smart phone and tablet computer (for example, flat
Plate computer) equipment of associated function, portable gaming device, portable media player, multimedia equipment, satellite navigation
Equipment (for example, global positioning system (GPS) navigation equipment), eBook reader device (electronic reader), smart television
(TV) equipment, surface calculate equipment (for example, desktop computer), personal computer (PC) equipment and use based on the man-machine of touch
The other equipment at interface.Reporter 1500 can (Figure 14 shows nothing via one or more connection and wireless communication mechanism
Line communication mechanism 1508) communicated with remote location 1506 (for example, sending and receiving signal of communication), the communication mechanism include but
It is not limited to acoustic communication signal, optical communication signal, radiocommunication signals, Infrared communications signals, ultrasonic communication signal etc..
In one embodiment, remote location 1506 includes being configured as storing and executing one or more computers and can holding
The computer system of line program, thus reporter can be stored in computer system program interaction (for example, remote access,
Execute etc.) and modified.For example, Figure 14 shows remote location 1506 comprising computer system 610, computer system 610
With the computer executable program 612 being stored thereon.In one embodiment, department of computer science is supplied to by reporter 1500
The information of system 610 is used for the field of to-fill procedure, such as field associated with the risk of repeated stress damage.Implement one
In scheme, program 612 includes dispatcher software, is configured to supply personal scheduling function, such as by personnel placement to knot of tissue
In particular task in structure, while considering the risk of repeated stress damage relevant to the various tasks that personnel are participated in, and
And the reality of the practical risk of the repeated stress damage including the individual engaged with system 1000 provided by reporter 1500
Data.For example, dispatcher software may include making computer system when being executed by the computer processor in computer system 610
610 provide the instruction of real time personnel scheduling.Reporter 1500 based on movement, position and the physiological status measured can be and system
The one or more individual of 1000 engagements provides information relevant to the repeated risk of stress damage, so as to the progress of program 612
Real time personnel dispatching distribution, such as personnel assignment substantially determine immediately or in real time, so as on personal basis, tissue
Basis etc. minimizes the risk of repeated stress damage.
For in another example, dispatcher software may include instruction, when by the computer processor in computer system 610
When execution, which makes computer system 610 provide long-term personal scheduling.Reporter 1500 can based on measure movement, position
Set one or more individuals with physiological status to be engaged to system 1000 provide it is relevant with the repeated risk of stress damage
Information so that program 612 carries out long-term personal scheduling distribution, such as is over time determined personnel assignment, with
Just personal basis, in terms of the risk of repeated stress damage minimized.
For in another example, dispatcher software may include executing when by the computer processor in computer system 610
When make computer system 610 provide personnel tracking instruction.Reporter 1500 can be based on movement, position and the physiology shape measured
Condition provides information relevant with the repeated risk of stress damage for the one or more individuals engaged to system 1000, so as to journey
The risk of the tracking of sequence 612 repeated stress damage relevant to particular individual, can coordinate with the specific distribution of tracking individual,
Such as to be determined based on risk of the specific distribution task by individual processing to individual repeated stress damage.With it is groups of
Individual is compared, and can be used for tracking the tendency of the repeated stress damage risk of individual by the information that reporter 1500 provides, such as
To determine whether particular individual than the groups of individual is engaged in the harmful activity of more biomethanics, whether to determine particular individual
More biomethanics nocuousness positioning are engaged in than the groups of individual (to distribute for executing with particular job for example, individual has
The incorrect form of associated various tasks), etc..
Figure 15 A shows the example context of the embodiment of the system of may be implemented 1000.As shown, system 1000 is located at
On the finger 1600a of subject.In one embodiment, system 1000 further includes the second equipment, which is configured as
Believed based on the detection to movements of parts of the body, position and physiological parameter where the second equipment to generate one or more sensings
Number.Then, second device can influence the physical feeling where it, as described by the effector 1008 herein with reference to system 1000
's.For example, as shown in fig. 15, system 1000 includes another finger 1600b of the same hand positioned at subject, but can be with
It is configured using other positions, but includes but is not limited to the different piece that the second equipment 1602 is located in same finger 1600a
On, or the second equipment 1602 is located in hand, wrist, toe, foot, ankle, arm, ancon, leg, knee, shoulder, hip
Portion, backbone position (for example, close to region of one or more of cervical vertebra, thoracic vertebrae, lumbar vertebrae, sacrum backbone and tail bone), flank position
(for example, the region of close rib cage, such as rib cage are attached the position of backbone), trunk, neck and head zone are (for example, face, head
Skin) on.
In one embodiment, example is shown in Figure 15 B, and the second equipment 1602 includes deformable substrate 1604, passes
Sensor component 1606, processor 1608 and effector 1610.Second equipment 1602 includes epidermis electronic system (EES) to monitor use
In physiology, the position of monitoring, prevention and treatment medical conditions relevant to repeated stress damage, arthritis or other medical conditions
It sets and moving situation.Deformable substrate 1604 is deformable (for example, flexible, stretchable) substrate, is configured to subject's
Skin surface engagement.The deformable nature of substrate 1604 promotes interaction/engagement with skin surface, and skin surface is usually
Low modulus and deformable natural surface.In one embodiment, the structure of substrate 1604 is with as described herein with corresponding
The structure of the substrate 1002 of function is similar or identical.
As shown in fig. 15b, the sensor module 1606 of the second equipment 1602 includes that motion sensor 1612 and physiology sense
Device 1614.Sensor module 1606 is configured as based on by inspection of the motion sensor 1612 to movements of parts of the body or position
It surveys and biosensor 1614 generates one or more sensing signals to the detection of the physiological parameter of physical feeling.Implement one
In scheme, the structure of sensor module 1606, motion sensor 1612 and biosensor 1614 respectively with biography described herein
Sensor component 1004, motion sensor 1010 and 1012 structure of biosensor are similar or identical comprising but be not limited to have
Accelerometer, proximity sensor, electromyograph (EMG), the strain transducer, temperature sensor, optics of corresponding function
Sensor and acoustic sensor.
Processor 1608 is configured as receiving one or more sensing signals from sensor module 1606 and handles sensing letter
Number, to provide control signal to the part of the second equipment 1602, such as is provided to effector 1610 and control signal.Implement one
In scheme, the structure of processor 1608 is similar with the structure of the processor 1006 described herein with corresponding function or phase
Together.
Effector 1610 is operatively coupled to processor 1608 and in response to processor 1608 in following operation
One or more is controlled and influences physical feeling: being prevented and treated and repeated stress damage, arthritis or other medicine
The relevant medical conditions of situation.For example, effector 1610 is under the control of processor 1608 based on to from sensor module
The processing of 1606 one or more sensing signals influences finger 1600b.In one embodiment, the structure of effector 1610
Similar or like with the structure of the effector 1008 as described herein with corresponding function, effector 1008 includes but is not limited to
Tactile stimulator and nerve stimulator.
In one embodiment, one or more components of system 1000 are interacted with the second equipment 1602.System 1000
One or more components and the second equipment 1602 be configured as in detection system 1000 and the second equipment 1602 it is corresponding other
Component presence.Belong to for example, the motion sensor 1010 of system 1000 can sense the one or more of the second equipment 1602
Property is to detect the presence of the second equipment on finger 1600b, and the motion sensor 1612 of the second equipment 1602 can sense and be
One or more attributes of system 1000, such as the presence of the substrate 1002 on finger 1600a, with depositing for detection system 1000
?.In one embodiment, the motion sensor 1010 of system 1000 can sense one or more attributes of finger 1600b with
Detect finger 1600b presence, finger 1600b relative to finger 1600a the degree of approach and finger 1600b relative to finger
One or more of arrangement of 1600a.In one embodiment, the motion sensor 1612 of the second equipment can sense finger
One or more attributes of 1600a to detect the presence of finger 1600a, finger 1600a relative to finger 1600b the degree of approach with
And arrangement one or more of of the finger 1600a relative to finger 1600b.
In one embodiment, as shown in fig. 15b, the second equipment 1602 includes communication interface 1616, is used for from second
Equipment 1602 send signal of communication, and via one or more connection (for example, wired connections) and wireless communication mechanism from
Remote location or equipment receive signal of communication, the communication mechanism include but is not limited to acoustic communication signal, optical communication signal,
Radiocommunication signals, Infrared communications signals, ultrasonic communication signal etc..Figure 15 B shows an embodiment, wherein communication connects
Mouth 1616 includes the reporter 1618 for being configured as transmitting information from the second equipment 1602.Information from reporter 1618 can be with
By visual means (for example, visual information), audible mode (for example, auditory information) and as data (for example, with to pass
The associated one or more data-signals of the information sent) one or more of provide.In one embodiment, reporter
The structure and function of 1618 structure and function and reporter 1500 as described herein is similar or identical.
In one embodiment, the communication interface 1616 of the second equipment 1602 promotes the second equipment 1602 and system 1000
Communication and interaction between other component (including but not limited to processor 1006 and reporter 1500).Therefore, communication interface
1616 promote the data between the second equipment 1602 and the other component of system 1000 to transmit.Data may include but be not limited to and imitate
The actuating of device (for example, effector 1008, effector 1610) is answered, the movements of parts of the body detected or position are (for example, by transporting
Dynamic sensor 1010, motion sensor 1612 sense), the physiological status detected (is passed by biosensor 1012, physiology
What sensor 1614 sensed), about the warning or instruction of movements of parts of the body, position and physiological status, with physical feeling
Movement, position and physiological status it is related warning or instruction it has been reported that instruction, physical feeling is relative to another body
The position of position and the second equipment 1602 are relative to one or more phases in the position of one or more components of system 1000
Associated data.
Referring now to Figure 16, showing the example context 1700 that embodiment may be implemented.Environment 1700 includes the first system
System 1702, second system 1704 and the communication interface 1706 being coupled between the first system 1702 and second system 1704.First
System 1702 and second system 1704 be configured as monitoring, prevent and treat with the relevant medical conditions of repeatability stress damage,
Arthritis or other medical conditions, and physiology, position and moving situation are monitored using epidermis electronic system (EES), to monitor,
Prevent and treat medical conditions relevant to repeated stress damage, arthritis or other medical conditions.Communication interface 1706 is just
In the one or more signals of communication of transmission between the first system 1702 and second system 1704.As shown, the first system
1702 include: deformable substrate 1708, is configured to interact with the skin surface of particular body portion;Including motion-sensing
The sensor module 1710 of device 1712 and biosensor 1714 is configured to based on motion sensor 1712 to physical feeling
Movement detection and biosensor 1714 one or more sensing letters are generated to the detection of the physiological parameter of physical feeling
Number;Processor 1716 is configured as receiving one or more sensing signals from sensor module 1710 and handles sensing signal
To provide control signal to the part of the first system 1702;And effector 1718, it is operatively coupled to processor 816
To influence body part to the control of one or more of following operation in response to processor 1716: prevent and treat with again
The relevant medical conditions of renaturation stress damage, arthritis or other medical conditions.Substrate 1708, sensor module 1710, processing
Device 1716 and effector 1718 can correspond respectively to substrate 1002, sensor module 1004, processor 1006 and effector
1008.Second system 1704 includes: deformable substrate 1720, is configured as the skin surface phase interaction with particular body portion
With;Sensor module 1722 including motion sensor 1724 and biosensor 1726 is configured as being based on passing through movement
Sensor 1724 is to the detection of movements of parts of the body and by biosensor 1726 to the physiological parameter of physical feeling
Detection is to generate one or more sensing signals;Processor 1728, be configured as from sensor module 1722 receive one or
Multiple sensing signals simultaneously handle sensing signal to provide control signal to the part of second system 1704;With effector 1730,
It is operatively coupled to processor 1728, to come in response to control of the processor 1728 to one or more of following operation
It influences body part: preventing and treating medical conditions relevant to repeated stress damage, arthritis or other medical conditions.Base
Plate 1720, sensor module 1722, processor 1728 and effector 1730 can correspond respectively to substrate 1604, sensor module
1606, processor 1608 and effector 1610.Communication interface 1706 promotes between the first system 1702 and second system 1704
Communication, and the logical of one or more of the first system 1702 and second system 1704 and remote equipment or position can be promoted
Letter.In one embodiment, communication interface 1706 includes and one or more of the first system 1702 and second system 1706
Associated reporter, such as with reference to described in reporter 1500 and reporter 1618.In one embodiment, example context
1700 include the electricity with one or more power communications in the first system 1702, second system 1704 and communication interface 1706
Source.For example, power supply can be remotely located from the first system 1702, second system 1704 and communication interface 1706, and to the first system
System 1702, second system 1704 and communication interface 1706 provide one or more wireless power signals.
Figure 17 shows for monitor, prevent and treat to the relevant medical conditions of repeatability stress damage, arthritis or
The method 1800 of other medical conditions.Method 1800, which is shown, detects body via epidermis electronic system (EES) in frame 1802
At least one of the position at position and movement.For example, the movement provided in the system (such as system 1000) based on EES passes
Sensor 1010 can detecte at least one of position and movement of physical feeling as described herein.Method 1800 further includes in frame
One or more sensing signals are generated based on the detection of position and at least one of movement to physical feeling in 1804.Example
Such as, motion sensor 1010 can based on to physical feeling position and movement at least one of detection come generate one or
Multiple sensing signals, as described herein.Method 1800 further includes handling one or more sensing signals in frame 1806 with determination
Cause the risk of repeated stress damage.For example, processor 1006 can receive the motion sensor from sensor module 1004
The 1010 one or more sensing signals generated, and can handle one or more sensing signals and cause repeatability to be answered with determination
The risk of power damage, such as realized by accessing and executing comparison module 1300, as described herein.Method 1800 further include
Execution movement is in frame 1808 to reduce the risk for causing repeated stress damage.For example, processor 1006 can be to effector
1008, which provide one or more control signals, reduces the risk for causing repeated stress damage to influence physical feeling, such as herein
It is described.
Figure 18 depicts other aspects of method 1800 shown in Figure 17.Frame 1806 shows the one or more senses of processing
Signal is surveyed to determine the risk for causing repeated stress damage, and including optional frame 1900, optional frame 1900 is shown one
A or multiple sensing signals are compared to determine the risk for causing strain Damage with the reference data for indicating strain Damage.Example
Such as, processor 1006 is accessible and executes comparison module 1300, the one or more that will be generated by sensor module 1004
Sensing signal is compared with the reference data for indicating strain Damage.Frame 1900 further includes optional frame 1902, and it illustrates be based on
By one or more sensing signals and indicate that the reference data of strain Damage is compared to the determination movement to be executed.For example,
Processor 1006 can determine effect compared with the reference data for indicating strain Damage by sensing signal based on one or more
Which device 1008 takes act: in the case where guaranteeing to act immediately, processor 1006 can be determined to be pierced by effector 1008
Nerve conduction is swashed to cause movements of parts of the body;In the lesser situation of risk of repeated stress damage, processor 1006
It can determine and provide touching simulation by effector 1008.
Figure 19 depicts other aspects of method 1800 shown in Figure 17.Frame 1806 shows execution movement and is drawn with reducing
The risk of repeated stress damage is played, and including optional frame 2000, it illustrates report induced repetitive strain Damages
The determination of risk is to reduce risk.Frame 2000 includes optional frame 2002, and it illustrates provide the tactile instruction of risk.Frame 2002 wraps
Optional frame 2004 is included, it illustrates the risk provided based on vibration instruction and optional frames 2006, and it illustrates provide about body
The tactile of the position at position indicates.Frame 2006 includes optional frame 2008, is biomethanics nocuousness position it illustrates the position is provided
The tactile instruction set and frame 2010, the time for being in the position it illustrates offer physical feeling compare threshold duration
Time longer tactile instruction.
Figure 20 depicts other aspects of method 1800 shown in Figure 19.Frame 1806 shows execution movement and is drawn with reducing
The risk of repeated stress damage is played, and including optional frame 2000, it illustrates reports to determine that causing repeatability answers loss on transmission
The risk of wound is to reduce risk.Frame 2000 includes optional frame 2100, and it illustrates provide visually indicating for risk.Frame 2100 includes
Optional frame 2102 shows and provides visually indicating for the position about physical feeling.Frame 2102 includes optional frame 2104, is shown
There is provided the position be biomethanics nocuousness position visually indicate and optional frame 2106, it illustrates provide physical feeling
The time for being in the position longer than threshold duration visually indicates.
Figure 21 depicts other aspects of method 1800 shown in Figure 19.Frame 1806 shows execution movement and is drawn with reducing
The risk of repeated stress damage is played, and including optional frame 2000, it illustrates reports to determine that causing repeatability answers loss on transmission
The risk of wound is to reduce risk.Frame 2000 includes optional frame 2200, and it illustrates provide the audible indication of risk.Frame 2200 includes
Optional frame 2202, it illustrates provide the audible indication of the position about physical feeling.Frame 2202 includes optional frame 2204, is shown
The audible indication and optional frame 2206 for providing that the position is biomethanics nocuousness position are gone out, it illustrates provide body
Position has been in the time audible indication longer than threshold duration of position.
Figure 22 depicts other aspects of method 1800 shown in Figure 19.Frame 1806 shows execution movement and is drawn with reducing
The risk of repeated stress damage is played, and including optional frame 2000, it illustrates reports to determine that causing repeatability answers loss on transmission
The risk of wound is to reduce risk.Frame 2000 includes optional frame 2300,2302,2304 and 2306.Frame 2300 shows report and is matched
At least one in the actuating for being set to the effector of execution movement, the movements of parts of the body detected or the physiological status detected
Person.Frame 2302, which is shown, provides the warning of the risk of biomethanics nocuousness positioning of physical feeling.Frame 2304 shows offer shifting
It leaves the instruction of body region.Frame 2306, which is shown, is transmitted to remote location and including optional frame 2308 and optional frame for determination
2310, optional frame 2308 shows the program interaction with storage on the computer systems, and optional frame 2310 shows modification storage
Program on the computer systems.
Figure 23 depicts other aspects of method 1800 shown in Figure 17.Frame 1808 shows execution movement and is drawn with reducing
The risk of repeated stress damage is played, and including optional frame 2400, it illustrates the nerves stimulated close to physical feeling.Frame
2400 include optional frame 2402, and it illustrates cause physical feeling by stimulating the nerve conduction of the nerve close to physical feeling
Movement or at least one of feeling.Frame 2402 includes optional frame 2404, specific it illustrates being maintained in physical feeling
In causing movements of parts of the body after the position duration threshold period by the nerve conduction of stimulation nerve or feeling extremely
Few one.
Figure 24 depicts other aspects of method 1800 shown in Figure 17.Frame 1808 shows execution movement and is drawn with reducing
The risk of repeated stress damage is played, and including optional frame 2500, it illustrates power blocks close to the nerve of physical feeling
Nerve conduction.Frame 2500 include optional frame 2502, it illustrates power block close to physical feeling nerve nerve conduction with
Inhibition of pain receptor and optional frame 2504, display power block close to physical feeling nerve nerve conduction to inhibit body
The movement of body region.
Figure 25 depicts other aspects of method 1800 shown in Figure 17.Frame 1802 is shown via epidermis electronic system
(EES) detect at least one of the position and movement of physical feeling, and including optional frame 2600,2602,2604,2606,
2608 and 2610.Frame 2600 shows the repeating motion via epidermis electronic system (EES) measurement physical feeling.Frame 2602 is shown
Via the number of repetition of epidermis electronic system (EES) measurement movements of parts of the body.Frame 2604 is shown via epidermis electronics
System (EES) measures movements of parts of the body speed.Frame 2606, which is shown, measures physical feeling via epidermis electronic system (EES)
Exercise duration.Frame 2608 is shown via epidermis electronic system (EES) measurement physical feeling relative to the second body
The arrangement of position.Frame 2610, which is shown, measures movements of parts of the body angle via epidermis electronic system (EES).
Figure 26 depicts other aspects of method 1800 shown in Figure 17, and including optional frame 2700, it illustrates
Via the physiological parameter and optional frame 2702 of epidermis electronic system (EES) detection physical feeling, it illustrates based on to body
The detection of the physiological parameter at position generates one or more sensing signals.
Figure 27 depicts other aspects of method 1800 shown in Figure 26.Frame 2700 is shown via epidermis electronic system
(EES) physiological parameter of physical feeling is detected, and including optional frame 2800,2802,2804,2806 and 2808.Frame 2800 shows
The temperature of detection physical feeling is gone out.Frame 2802 shows the strain of detection physical feeling.Frame 2804 shows detection body
The blood flow of position.Frame 2806 shows the blood oxygen level of detection physical feeling.Frame 2808 shows the electrical activity of detection physical feeling.
Figure 28 depicts other aspects of method 1800 shown in Figure 17, and including optional frame 2900, it illustrates
Via the arrangement of epidermis electronic system (EES) detection physical feeling.Frame 2900 includes optional frame 2902, and it illustrates via epidermis
Electronic system (EES) detects angle and optional frame 2904 close to the joint of physical feeling, and it illustrates via epidermis electronics
System (EES) detects the arrangement of physical feeling whithin a period of time.
Figure 29 depicts other aspects of method 1800 shown in Figure 17, and including optional frame 3000, it illustrates
The equipment engaged at least one of the physical feeling and another physical feeling is detected via epidermis electronic system (EES), with
And optional frame 3002, it illustrates send signal of communication to equipment.Frame 3002 includes optional frame 3004, and it illustrates transmissions to be based on
The one or more sensing signals generated to the detection of at least one of the position of physical feeling and movement are to equipment.
Figure 30 depicts other aspects of method 1800 shown in Figure 17, and including optional frame 3100, it illustrates
At least one in the position and movement of the second physical feeling of the physical feeling is detected via epidermis electronic system (EES)
Person.
Also describe the system, apparatus and method for monitoring and treating pain and associated disease.Pain can be attributed to
Many physiology and nervous disorders, and can be experienced according to various pain status by individual subjects.In one embodiment, pain
State includes types of pain, pain level, pain quality or combinations thereof.For example, pain status may include non-pain state, pain hair
Work, PAIN MODEL, chronic ache, Acute Pain, Combination pain status, Hyperalgesic pain state, allodynic state,
Breakthrough pain state, neuropathic pain state, nociceptive pain state, non-nociceptive pain state, a combination thereof etc..Pain
Type may include such as nociceptive pain (for example, since mechanical, heat and/or chemical interaction cause), body pain, nerve
Property pain, visceral pain, facial pain and psychogenic pain, wherein various types of pain can be according to specific biosystem or position
Set (for example, muscle skeleton, neuropathic etc.) experience, or can be non local.For example, types of pain may include spontaneous
Property pain (for example, in the case where there is no stimulation), caused pain (for example, occurring in response to stimulation), lasting pain
Pain or intermittent pain.For example, pain level may include the intensity, seriousness or degree of pain.Pain quality may include but not
It is limited to intensity, violent degree, dullness, scorching hot, cold, tenderness, itch, spasm, radioactivity, tingling, palpitates from nervousness, pain, fatigue, depth
Spend, tremble or shock by electricity, stab etc., with and combinations thereof.The assessment tool for assessing pain status can be for example including instrument or instrument
Combination and designed for monitor physiological reaction related software, physiological reaction include chemical change, biopotential, muscle swash
Living and its variation.Assess pain status assessment tool can for example including instrument or instrument combination (for example, motion sensor,
Biosensor or combinations thereof) and the related software designed for monitoring autonomic response as described herein.For example, assessment pain
The assessment tool of state may include subjective tool, such as pain quality evaluation scale and McGill pain questionnaire.Implement one
In scheme, subjective tool can be provided to system 1000 with baseline or compared with the associated data of pain level, in turn can be with
As threshold value pain level or other comparison pain indexs.
Pain is generally existing in human and animal group.Only lift several examples, it was reported that most of crowds (60% to
85%) its in life sometime live through muscle origin back pain, about 30% population experience muscular fascia touching
Pain caused by hair point.About 50,000,000 Americans suffer from arthritis (such as osteoarthritis or inflammatory arthritis), and at least
30% patient with moderate chronic pain and the patient with significant chronic pain more than 50% fail to obtain enough
Pain relief.Therefore, pain is to seek the personal common factor of medical treatment etc..With traditional treatment pain and shortage treatment pain
Bitterly relevant cost (for example, lost wages, deformity, medical facilities cost etc.) has a significant impact to entire society's tool.For example, according to
Report, based on the lost wages as caused by disabled and other indirect expenses, 2003, which are only arthritic macroeconomy influence, is
128000000000 dollars.In addition, being to be mutually related on pain and motion essence.Known movement and the cause of disease of pain and its illness, effect
Fruit, prevention and treatment are related.System described herein, device and method from be located at subject physical feeling near one or
Multiple biosensors and motion sensor generate sensing signal, to provide the physiological status of individual subjects (for example, pain shape
State) index.In one embodiment, system and method described herein can be used for by sensing from one or more physiology
Device and motion sensor generate sensing signal to monitor and treat individual subjects pain experienced, one or more of lifes
Reason sensor and motion sensor are configured as the one or more physiological parameters and individual subjects of monitoring individual subject
One or more movements of physical feeling or position, and effect is provided to physical feeling by the effect of one or more effectors
Fruit.For example, ultrasonic transducer can be used as the effector for influencing individual subjects, such as to control in system, apparatus and method
Treat pain relevant to movements of parts of the body, pain relevant with physiological parameter or combinations thereof.
In embodiments, movements of parts of the body can indicate the pain of Individual Experience.For example, can cause to ache to movement
The conscious or unconscious fear of pain can change movements of parts of the body, to indicate acute or chronic pain.For example, to urgency
Property pain or chronic ache physiological adaptability can cause movements of parts of the body function short-term or change in long term (for example, increase
Or inhibit muscle activation), and therefore can indicate pain.For example, the change of physical feeling movement can show as influencing body
The movement at position (for example, muscle) or the significant of excitement minimize, protectiveness moves, clumsy gait, limping, activity or stress
Redistribute, the change of load, obviously using non-advantage limbs, reduce force production, lack using physical feeling, work of breathing
Energy obstacle, clamping plate use.For example, conscious or unconscious coping mechanism is (for example, grimacing, obviously rubbing or massaging body
Body region etc.) it can indicate pain.For example, non-autonomous reaction (for example, reflection, spasm etc.) can indicate pain.Implementing
In scheme, individual movements of parts of the body can be the source of pain, reason, or induction or deterioration pain, and therefore, can
To determine that special exercise is associated with pain.For example, certain movements can repeat related (example to the increase of pain in time
Such as, it is indicated by the variation of autonomic response or by Subjective Reports, the variation of the autonomic response is raw by chemical sensor, electricity
Manage the measurement such as sensor, biopotential transducer).In embodiments, individual movements of parts of the body can be pain
Prophylactic treatment or therapeutic treatment.For example, lacking movement or repeating motion can indicate that pain risk increases, and indicate appropriate
The movement for treating or preventing the sensing and record of movement can indicate the reduction of pain risk.In one embodiment, muscular fatigue
Can be associated with myalgia, myalgia can be caused or can be the index of myalgia.
In one embodiment, movements of parts of the body can be provided about when can using or should use effector
Treatment instruction.For example, effector can be used in physical feeling experience (for example, previously or same in system, apparatus and method
When) determine the associated movement of the increase with pain when to individual subjects provide treatment, for example, as palliative treatment.Example
Such as, system, apparatus and method can be used effector come in the physical feeling of individual subjects lack movement or individual by
Examination person rested a period of time more than threshold time period when to individual subjects provide treatment.Induce individual subjects fortune
The dynamic treatment carried out can be precautionary measures (for example, induced motion is to prevent arthralgia, myalgia or the breaking-out of pressure sore).For example,
System, apparatus and method can be used effector individual subjects be in rest (for example, currently do not undergo substantial motion,
Such as take exercise, walk, language of making a sign with the hand etc.) when to individual subjects provide treatment.To individual subjects during resting state
Convenient and non-interrupted mechanism can be provided to treat the pain of individual subjects experience (for example, chronic or long-term pain by treating
Bitterly).
In one embodiment, system and method described herein is tested to monitor using one or more biosensors
One or more physiological status of person simultaneously generate sensing signal in response to this.Biosensor may include, but be not limited to, and electricity is raw
Reason sensor, electrocardiograph, electroculogram tracer (electrooculograph), micro- nerve trace electrode, flesh is moved and traced
Device, electromyograph (for example, surface electromyography tracer), acoustics flesh move and trace sensor, mechanical flesh moves and traces sensor,
Accelerometer flesh is dynamic trace sensor, strain transducer, pressure sensor, temperature sensor, optical sensor (for example, LED,
Pulse blood oxygen instrument etc.), near infrared sensor, skin conductance sensor, bio-impedance sensor, pH sensor, acoustic sensor,
Chemical sensor.
In one embodiment, system and method described herein is using one or more motion sensors come monitoring individual
The movements of parts of the body of subject or position, and sensing signal is generated in response to this.Motion sensor may include but be not limited to
Aspect sensor, accelerometer, proximity sensor (for example, infrared sensor, optical sensor etc.), force snesor, pressure pass
Sensor is configured as the repetition for measuring the sensor of the repeating motion of physical feeling, being configured as measurement movements of parts of the body
The sensor of number is configured as measuring the sensor of the speed of movements of parts of the body, is configured as measurement physical feeling
The sensor of the duration of movement, be configured as measurement physical feeling relative to the arrangement of the second physical feeling sensor,
It is configured as the sensor of measurement movements of parts of the body angle.Movements of parts of the body can indicate the pain of Individual Experience,
Can indicate the risk of pain, can indicate the source of pain, can provide about when can be used treatment expression or its
Combination.
In one embodiment, system and method described herein is using one or more effectors come in response to sensor
Component generate sensing signal processing and influence physical feeling.For example, one or more effectors may include one or more
Ultrasonic transducer, the ultrasonic transducer include but is not limited to ultrasound transducer array, are configured to generate low intensity ultrasound letter
Number ultrasonic transducer, be configured to generate high intensity focused ultrasound signal ultrasonic transducer, be configured to generate as low
The ultrasonic transduction of the ultrasonic signal of the high-frequency ultrasonic signal of dosage is configured to generate the super of ultrasonic signal on the basis of chopping
Sonic transducer, is configured to according to multiple treatment moulds the ultrasonic transducer for being configured to generate ultrasonic signal in continuous foundation
Formula generate ultrasonic signal ultrasonic transducer, be configured to according to multiple supersonic frequencies generate ultrasonic signal ultrasonic transducer,
It is configured to be placed on the ultrasonic transducer of the different location in the physical feeling of individual subjects.One or more effectors can
Including but not limited to electrode, magnetic stimulator, photic stimulator are (for example, being configured to generate the photic stimulator of infrared light, being configured to
Generate the photic stimulator etc. of low intensity pulse infrared light, and combinations thereof), caloric stimulator and combinations thereof.
In one embodiment, referring generally to Fig. 9-14 and 31-36, system 1000 (or pain therapy equipment) is configured
For monitoring and treating individual subjects pain experienced.System 1000 includes substrate 1002, sensor module 1004, processing
Device 1006 and effector 1008 are placed in individual subjects with the pain indication of monitoring individual subject and pass through effector
1008 URIN Treatment pain.In one embodiment, system 1000 includes epidermis electronic system (EES) or combines epidermis electric
The equipment of sub-device, to monitor physiology, position and moving situation, to monitor, to prevent and treat individual subjects experienced
Pain.Substrate 1002 is configured as: meeting the profile (for example, curvature of limbs) and body of the physical feeling of individual subjects
The skin surface engagement at position, or combinations thereof.For example, substrate 1002 may include deformable (for example, conformal, flexible, stretchable
Deng) material, it is configured to engage and meet physical feeling, including but not limited to engages and meet the skin surface of physical feeling.
Physical feeling such as Figure 10 is shown as wrist 1000, however, system 100 can be positioned in any physical feeling, the body
Position includes but is not limited to arm, ancon, wrist, hand, finger, leg, buttocks, knee, ankle, foot, toe, facial area, head
Region (for example, close to region of one or more cranium fleshes on face or head), neck area, torso area, backbone position, sacrum
Ilium joint etc. or its skin part.The flexible nature (for example, flexibility and tensility) of substrate 1002 promotes and physical feeling
Interaction/engagement, which includes usual low modulus and deformable natural skin surface.In an embodiment
In, substrate 1002 may include stretchable/flexible fabric, paper or polymer (for example, natural or synthetic elastomer polymer, polyamides
Imines, polyethylene, organic polymer, such as PDMS, sub- dimethylbenzene, Parylene, inorganic polymer, biopolymer are multiple
Condensation material or any combination of them), diaphragm (for example, hydrocolloid diaphragm), film (for example, nanometer film, such as silicon nanometer film),
With one of breathable elastomeric piece or other deformable (for example, stretchable, flexible, flexible) materials or a variety of.Root
According to various mechanism, substrate 1002 be can be positioned near skin surface, including but not limited to be fixed to skin by jointing material
On, by external pressure (such as by surround or around physical feeling winding material (for example, fabric, clothes, gloves, bandage
Deng) pressure that provides) be held in place, it is fixed on textile, fabric, clothes, accessory (such as gloves, socks, fingerstall
Deng) in etc..
In one embodiment, system 1000 includes at least one flexible or stretchable electronic component.For example, sensor
Component 1004 (for example, motion sensor 1010, biosensor 1012 etc. as described herein), processor (and interlock circuit)
At least one of 1006 or effector 1008 may include being coupled to the flexible or stretchable electronic device of substrate 1002 by it
It is formed.For example, the interconnection (not shown) between these components or in circuit may include flexible or stretchable electronic device (example
Such as, snakelike conductive trace realizes stretchable interconnection) or formed by it, and it is coupled to substrate 1002.For example, power supply (example
Such as, power supply 1200 as described herein) it may include flexible or stretchable electronic device or by flexible or stretchable electronics
Device is formed, and is may be coupled on substrate 1002.In one embodiment, at least one flexible or stretchable ministry of electronics industry
Part is included at least one of waveform, bending, grid (for example, open grid), buckle or snakelike geometry.It is real one
It applies in scheme, at least one described flexible or stretchable electronic component includes at least one nano wire, at least one nanobelt
Or at least one nanometer film.For example, system 1000 may include the one or more multifunction electronics for including stretchable/flexiblesystem
Unit, stretchable/flexiblesystem include the sensor module communicated by interlock circuit (for example, using processor 1006)
(for example, sensor module 1004), effector (for example, effector 1008) and power supply (for example, power supply 1200), it is described mutually powered-down
Road includes the interconnection piece resided among or on deformable substrate (for example, substrate 1002).
In one embodiment, system 1000 may include at least one super-thin electronic component.For example, ultra-thin (for example, being less than
20 microns) electronic component may include thinned chip (for example, the thinned silicon wafer for being adhered to polymeric substrates), ultra-thin core
Piece etc..For example, ultra-thin circuit may include by the hydatogenesis using ultraviolet (UV) photoetching and etching such as poly- to diformazan
The conductive layer formed on the deformable substrate (for example, substrate 1002) of benzene etc.For example, sensor module 1004, processor
At least one of 1006 or effector 1008 may include super-thin electronic device.
In one embodiment, system 1000 may include at least one conductor wire, yarn or fabric.For example, sensor group
Part 1004, processor 1006 or effector 1008 may include at least one conductor wire or yarn.Conductor wire, yarn or fabric can be with
Enough electric currents are configured to supply to cause at least one of the wired or wireless coupling between such as electronic component.Example
Such as, conductor wire, yarn or fabric, which can be formed, is configured as in one or more sensors component 1006, one or more effects
The processor 1006 (or its circuit) to work in communication between device 108 or other circuits of system 1000 or other circuits.
It works for example, conductor wire, yarn or fabric can be formed in the communication being configured between multiple multifunction electronic units
Circuit at least part, each multifunction electronic unit includes one or more sensors component 1006, one or more
Effector 1008 and processor 1006.Conductive fiber, line and yarn may include metal material, semi-metallic, semi insulating material,
Semiconductor material (for example, silicon and GaAs) or transparent conductive material (for example, indium tin oxide (ITO) material).For example, can
To use braiding, knitting or embroidery that electric wire or yarn are embedded in textile, or such as the non-of bonding etc can be used and knit
Production technology is made to be attached electric wire or yarn.For example, the conductive yarn with curved configuration can be (for example, by suture or lead to
Cross bonding) it is attached on elastic fabric and can be formed the sensor module of the individual one or more physical features of measurement
1004 all or part of, the measurement for example when since specific skin pattern etc. causes curved configuration to be changed into
Row.
Sensor module 1004 is coupled on substrate 1002 and including motion sensor 1010 and biosensor 1012.
Sensor module 1004 is configured as detection and biosensor based on motion sensor 1010 to movements of parts of the body
The detection of the physiological parameter of 1012 pairs of physical feelings generates one or more sensing signals.One or more sensing signals can be with
One or more movements of physical feeling, one or more physiological parameters or combinations thereof of physical feeling are associated.Implement one
In scheme, as shown in figure 31, motion sensor 1010 includes aspect sensor 3200 (for example, referring to figs. 1A to the list of Fig. 8 description
Member 120), in accelerometer (for example, accelerometer 1400) and proximity sensor (for example, proximity sensor 1402) one or
It is multiple, to detect movements of parts of the body and generate sensing signal in response to this.For example, aspect sensor 3200 may include such as this
Single-axis accelerometer described in text, the single-axis accelerometer of pairs of alignment relative, the antenna for being configured to measurement field source, distance pass
One or more of sensor, multi-axial accelerometer, gyroscope, inclinometer or combinations thereof, with based on physical feeling orientation or
Orientation differences measure movements of parts of the body.Proximity sensor 1402 may include infrared sensor (for example, infrared sensor
And one or more of optical sensor (for example, optical sensor 1406) 1404).In one embodiment, close to sensing
Device is configured as sensing the second physical feeling close to the physical feeling where system 1000.For example, system 1000 can position
In the wrist of individual subjects, and motion sensor 1010 may include proximity sensor, which is configured
For detect the presence of another physical feeling (such as hand, palm, arm, finger, shoulder etc.) of neighbouring wrist, position, angle and
One or more of movement.In one embodiment, proximity sensor 1402 is configured as sensing another with skin surface
Part or the equipment with another physical feeling interface.For example, system 1000 can be positioned at the physical feeling of individual subjects
On, and second system 1000 is located in physical feeling nearby or in another physical feeling, wherein the motion-sensing of system 1000
The proximity sensor of device 1010 can sense one or more of presence, position, angle and movement of second system 1000.?
In one embodiment, motion sensor 1010 includes pressure sensor, which can be individual sensor, or
Component as one or more of aspect sensor 3200 or proximity sensor 1402 is incorporated into.Pressure sensor can be with
It is more than one section of threshold duration that whether (for example, via sensing signal), which provides idle about individual or its physical feeling,
The instruction of time, this can provide index in turn for the operation of effector 1008.For example, what induction individual subjects movement carried out
Treatment can be precautionary measures (for example, induced motion is to prevent arthralgia, myalgia or the breaking-out of pressure sore).
Motion sensor 1010 is configured as one or more in the position of detection movements of parts of the body and physical feeling
It is a.Movements of parts of the body, the position of physical feeling or combinations thereof can indicate the pain status of individual subjects experience.Example
Such as, to movement can cause the conscious or unconscious fear of pain that can change movements of parts of the body, thus indicate it is acute or
Chronic ache.For example, to the physiological adaptability of Acute Pain or chronic ache can cause the short-term of movements of parts of the body function or
Change in long term (for example, increasing or inhibit muscle activation), and therefore can indicate pain.For example, the change of physical feeling movement
It can show as influencing the movement of physical feeling (for example, muscle) or the significant of excitement minimizes, protectiveness moves, clumsy step
State, limping, the redistributing of activity or stress, the change of load, obviously using non-advantage limbs, reduce force production, lack
It is used using physical feeling, respiratory dysfunction, clamping plate.For example, conscious or unconscious coping mechanism is (for example, play tricks
Face, obviously rub or the position etc. that harmonizes the body) can indicate pain.For example, non-autonomous reaction (for example, reflection, spasm etc.)
It can indicate pain.In embodiments, individual movements of parts of the body can be the source of pain, reason, or induction or
Deteriorate pain, and hence, it can be determined that special exercise is associated with pain.The position of movements of parts of the body, physical feeling
Or combinations thereof can indicate individual subjects experience the increased risk of pain, for example, when have determined movement in time with
When pain correlation (for example, as represented by variation of autonomic response) or when movement (for example, lacking movement) or repeating motion show
There are when pain risk.The physiological status of individual subjects can be determined with promoting processor 1006 by detecting these movements, this can be with
It assists in determining whether to treat individual subjects by the movement of effector 1008.In addition, movements of parts of the body can provide
About the instruction that when can be treated using effector 1008.For example, processor 1006 can (for example, via one or
Multiple control signal, such as electric control signal) instruction effector 1008 individual subjects be in rest (for example, currently without
Go through substantial motion, such as take exercise, walk, language of making a sign with the hand etc.) when to individual subjects provide treatment.For example, in physical feeling
When the associated movement of the increase with pain for undergoing (for example, previously or concurrently) to determine, processor 1006 can indicate effect
Device 1008 provides treatment to individual subjects, for example, as palliative treatment.For example, processor 1006 can indicate effector
1008 in the physical feeling of individual subjects lack movement or individual subjects rested more than threshold time period
Treatment is provided to individual subjects when a period of time.The treatment that induction individual subjects movement carries out can be precautionary measures (example
Such as, induced motion is to prevent arthralgia, myalgia or the breaking-out of pressure sore).
Physical feeling can be the position engaged with system 1000, or to can be the position engaged with system 1000 close
Position.In one embodiment, motion sensor 1010 generates sensing signal based on the repeating motion of physical feeling.For example,
System 1000 can be positioned in the wrist of subject, and motion sensor 1010 measures the repetition bending or bending of wrist,
Such as to be measured during hand or one or more finger movements.In one embodiment, motion sensor 1010 measures body
The number of repetition of the movement at position.For example, system 1000 can be positioned on the finger of subject, and motion sensor 1010
Measure specific finger bending or curved number of repetition.Measurement number of repetition may include but be not limited to measurement and zero repetition occurred,
Limited number of repetition is measured, duplicate number at the appointed time section is measured, and determines that number of repetition is more than threshold number (example
Such as, subject is made to be in the threshold value of the risk of pain).For example, can by motion sensor 1010, in processor 1006 or
One or more of counter 3202 or timer 3204 present in a combination thereof promote the measurement of number of repetition.It is real one
It applies in scheme, motion sensor 1010 measures movements of parts of the body speed.For example, system 1000 can be positioned at subject's
On ankle, and motion sensor 1010 measures the movement velocity of ankle, such as during walking movement during ankle flexion
The movement velocity of ankle, relative to the movement velocity on ground during walking movement or in the movement velocity during other movements
One or more.In one embodiment, motion sensor 1010 measures the movements of parts of the body duration.Duration
It may include total exercise duration (for example, duration comprising movement is repeated several times) and the single repetition in a period of time
One or more of total exercise duration of movement.Timer 3204 can promote this duration to measure.For example, being
System 1000 can be positioned on the cheek of individual subjects or close to facial muscles, and motion sensor 1010 measure cheek or
The duration (for example, to indicate funny face or the relevant physical feeling movement of other pain) of the contraction of facial muscles.Measurement moves
The dynamic period can include but is not limited to several seconds (for example, 10 seconds, 30 seconds), 1 minute, 20 minutes, 30 minutes, 1 hour, 1
Portion when subject in it is part when regaining consciousness and enlivening, the subject in 1 day is in sleep or other disabled states
Divide, 1 day or longer duration.In one embodiment, sensor module 1004 is configured as measuring whithin a period of time
The arrangement of physical feeling.For example, in movement, and being maintained at is not resting position in physical feeling is in static
While one or more of (for example, tension) position, sensor module 1004 can measure physical feeling over time
Arrangement.In one embodiment, the measurement of motion sensor 1010 is in the physical feeling where system 1000 relative to the second body
Arrangement of the body region during the movement of one or more of physical feeling and the second physical feeling.For example, system 1000 can
To be located on the phalanx of subject, and motion sensor 1010 measure phalanx relative to subject wrist or ankle in phalanx
Or the arrangement during the movement of wrist/ankle.In one embodiment, motion sensor 1010 measures movements of parts of the body angle
Degree.For example, system 1000 can be positioned on the arm of subject, and the measurement of motion sensor 1010 arm (for example, relative to
Trunk, relative to the resting position of arm, relative to another physical feeling etc.) movement angle.Pass through motion sensor
The 1010 measurement repeating motions of physical feeling, the number of repetition of movements of parts of the body, the speed of movements of parts of the body, body
Arrangement and movements of parts of the body angle of the duration, physical feeling of the movement at position relative to the second physical feeling
In one or more information provided can determine whether subject be undergoing pain or in experience with help system 1000
Pain risk (for example, delay breaking-out pain or repeated injury pain) in, such as move whether be pain symptom or pain
The reason of pain factor.
In one embodiment, motion sensor 1010 is configured as to indicate motion state, the individual of individual subjects
One or more sensing signals of the duration of the resting state of the resting state or individual subjects of subject are sent everywhere
Manage device 1006.For example, the motion state of individual subjects can indicate that individual subjects (or its physical feeling) are currently being transported
It is dynamic, and the resting state of individual subjects can indicate that individual subjects (or its physical feeling) do not move, or not surpass
It crosses the rate of threshold rates or is moved between orientation.In one embodiment, processor 1006 is based on coming from motion sensor
1010 sensing signal determines the resting state of individual.For example, processor 1006 can autokinesis in future sensor 1010 sense
It surveys signal and is in the reference data rested with physical feeling is indicated and is compared, to determine that the physical feeling of individual subjects is just
In experience resting state (for example, being under movement threshold or movement threshold relative to reference data) or active state (example
It such as, is more than movement threshold relative to reference data).In one embodiment, processor 1006 is configured to only in physical feeling
Activation effect device 1008 is influenced when rest with (for example, by ultrasound, electricity, magnetic, light or thermostimulation, as further described herein)
Physical feeling.For example, when the sensing signal from motion sensor 1010 indicates that physical feeling is undergoing resting state, place
Reason device 1006 can indicate effector 1008 (for example, via one or more electric control signals) activation to influence physical feeling.
For example, effector 1008 can be operated only when individual subjects or particular body portion to be treated are in rest, example
Such as when individual subjects are in sleep state, lie on furniture, drive or ride over vehicle it is medium when operation.In another example and
Speech, effector 1008 can be in rest in individual subjects or particular body portion to be treated or be in same position
The period for being continued above predetermined time length operates later.In one embodiment, processor 1006 is configured in response to
The predetermined amount of exercise of physical feeling and activation effect device 1008 are to influence physical feeling.For example, when coming from motion sensor 1010
Sensing signal indicate physical feeling meet or be more than predetermined amount of exercise when, for example, be more than physical feeling traveling threshold value away from
From, more than the threshold motion time of physical feeling, more than physical feeling threshold value orientation etc. whens, processor 1006 can indicate to imitate
Answer device 1008 (for example, by one or more electric control signals) activation to influence physical feeling.In one embodiment, it handles
Device 1006 is configured in response to the movement of the predefined type of physical feeling and activation effect device 1008 to influence physical feeling.Example
Such as, when the sensing signal from motion sensor 1010 indicates that physical feeling experienced certain types of movement, processor
1006 can indicate effector 1008 (for example, via one or more electric control signals) activation to influence physical feeling.For example,
Sensing signal from motion sensor 1010 can indicate that physical feeling undergoes certain types of movement, such as can indicate to ache
Gout nearly increased scheduled high movement velocity, the output of high-caliber power, too fast step (for example, indicate trip), certain party
Upward movement (for example, the distortion in instruction joint) etc..For example, the sensing signal from motion sensor 1010 can indicate shadow
Ring the obvious minimum of the movement or excitement of physical feeling (for example, muscle), such as " protection ".For example, coming from motion sensor
1010 sensing signal can indicate that physical feeling experienced certain types of movement, such as undergo scheduled movement velocity (example
Such as, individual subjects are being slowed down), face's distortion, clumsy gait, limpings, significantly rub using non-advantage limbs, obviously or
Harmonize the body position (for example, repetition or deep massage) etc., can indicate the discomfort of individual subjects experience or the degree of pain.
Such case may be used as processor 1006 should activation effect device 1008 index.
Biosensor 1012 is configured as one or more physiology ginseng of the individual subjects where detection system 1000
Number, wherein such physiological parameter can provide and whether be undergoing pain about individual subjects or individual subjects are passing through
The instruction of the pain for what degree gone through.In one embodiment, the detection of biosensor 1012 is by engaging with system 1000
One or more local physiologicals provided in physical feeling and the close physical feeling of the physical feeling engaged with system 1000
Parameter.In addition biosensor 1012 can be configured or alternatively be configured as the complete of the subject where detection system 1000
Body physiological parameter.In one embodiment, as shown in figure 32, biosensor 1012 may include electro-physiological sensor 3300, the heart
Electrograph tracer 3302, electroculogram tracer 3304, micro- neural tracer 3306, myograph 3308, electromyograph
(EMG) 3310, surface electromyography tracer 3312, acoustics flesh it is dynamic trace sensor 3314, mechanical flesh it is dynamic trace sensor 3316,
Accelerometer flesh is dynamic to be traced sensor 3318, strain transducer 3320, temperature sensor 3322, optical sensor 3324, shines
Diode (LED) 3326, oximeter 3328, near infrared sensor 3330, skin conductance sensor 3332, bio-impedance sensor
3334, pH sensor 3336, acoustic sensor 3338, chemical sensor 3340, pressure sensor 3342 or combinations thereof.For example,
Biosensor 1012 may include multiple sensors, such as the combination of multiple single sensor types or different sensors type,
Its is arranged in an array or otherwise (for example, via one or more leads and/or wireless coupling, such as in sensor position
Between setting) it is communicatively coupled.
Electro-physiological sensor 3300 can based on the physiological parameter to physical feeling detection (such as pass through detection with biology
The associated one or more electrical characteristics of cell or tissue) one or more sensing signals are generated, and may include brain electricity
Figure instrument (EEG) (for example, its electrical activity for being used to measure brain) includes silicon metal oxide semiconductor field effect transistor
(MOSFET) sensor electrode, the electrocardiograph (ECG) 3302 (for example, being measured for cardiac electrical activity), eye of amplification
Electrograph tracer (EOG) 3304 (for example, measuring for eye electrical activity), electromyograph (EMG) 3310 are (for example, for surveying
Measure the electrical activity of muscle), surface EMG3312 (for example, EMG of Noninvasive type), micro- neural tracer 3306 (for example, with
Electrical activity measurement in nerve fibre), skin conductance sensor 3332, one or more in bio-impedance sensor 3334 etc.
It is a.For example, the electro-physiological sensor of such as EEG, ECG, EOG or EMG (for example, surface EMG) etc may include one or more
Capacitance sensor or silicon metal oxide semiconductor field effect transistor (MOSFET).For capacitance sensing, electro-physiological sensor
3300 may include measuring electrode and the capacitively coupled reference electrode of measuring electrode and grounding electrode, thus feel in the electrodes
The displacement current answered provides data relevant to ECG, EMG, EOC etc..In one embodiment, one or more electrodes include with
The snakelike network of filiform of individual's skin surface insulation, such as the insulation with high dielectric constant, tensility and adhesiveness
Layer (for example, dimethyl silicone polymer).For example, the electro-physiological sensor of such as ECG etc may include one or more dry electrodes
Or comprising with such as silver-colored microballoon, the conductive material mixing of silver nanowires or carbon structure (e.g., including carbon nano-structured) etc
The conducting polymer of binder polymer (for example, dimethyl silicone polymer).It is set for example, EOG 3304 can be resident skin
Activity that is standby, being configured as in the muscle of detection control eyes and eyelid movement.For example, surface EMG may include piezoelectric membrane
Sensor.In one embodiment, electro-physiological sensor 3300 can be electro-physiological sensor array.In one embodiment,
The muscle activity of physical feeling where 3300 measuring system of electro-physiological sensor 1000, such as during physical feeling movement,
Measurement during during lacking movement or combinations thereof.For example, system 1000 can be positioned on the phalanx of subject, and electricity is raw
Phalanx of sensor 3300 (for example, EMG 3310) measurement of science in phalanx or the movement of wrist/ankle or during lacking movement
Muscle activity.
Myograph 3308 can based on the physiological parameter to physical feeling detection (such as by detection with one or
Multiple muscle associated one or more attributes) generate one or more sensing signals, and may include EMG 3310,
Surface EMG 3312, acoustics flesh move and trace sensor 3314 (for example, for measuring the sound in muscular movement), mechanical flesh is moved and retouched
Note sensor 3316 (for example, for measuring the oscillation in contraction of muscle), accelerometer flesh are moved and are traced in sensor 3318 etc.
It is one or more.For example, mechanical flesh is dynamic, to trace sensor 3316 may include Electret Condencer Microphone, the acceleration as detector
Meter, instrument based on laser etc..For example, acoustics flesh is dynamic, to trace sensor 3314 may include acoustic transducer.For example, acoustics flesh is dynamic
Tracing sensor 3314 may include the acoustic sensor with microphone.
In one embodiment, biosensor 1012 includes the electro-physiological sensor for being configured to measure bioelectrical signals
3300 (for example, EEG, ECG 3302), EOG 3304, micro- neural tracer 3306, EMG 3310, surface EMG 3312, acoustics
Flesh is dynamic to trace that sensor 3314, mechanical flesh are dynamic to trace that sensor 3316, accelerometer flesh are dynamic to trace sensor 3318 etc., wherein giving birth to
Object electric signal can indicate the pain status of individual subjects.In one embodiment, electro-physiological sensor 3300 includes being used for
Detect the EMG of the bioelectrical signals of the locally or systemically index as pain in muscle.For example, being located in subject's face
Surface EMG (for example, surface EMG 3312) on musculus can when muscle because subject feels body somewhere pain shrink when
The bioelectrical signals of (such as during grimacing or lower jaw is tightly stung) detection muscle.For example, the surface EMG being located on trapezius muscle can
To measure the high bioelectric for indicating high stress level relevant to experience pain.For example, being located at the surface EMG on biceps
The bioelectric of expression relevant to pain or pain risk excessive use and fatigue can be measured.For example, in repeated work
The surface EMG that period is located on muscle, which can be measured, indicates that repeated injury stress be with ache related or pain risk biology
Electrical activity.It is received for example, the surface EMG being located on muscle during movement can detecte expression sustained muscle relevant to pain
The bioelectrical signals of contracting (for example, muscle turns convulsion or spasm).For example, being located at one or more facial muscles or one or more necks
Surface EMG (for example, surface EMG 3312) on portion's muscle can detecte with audible or not audible voice (for example, pain
Bitterly relevant sounding) associated muscular movement.In one embodiment, electro-physiological sensor 3300 includes EMG, is used for
The flesh positioned relative to the second physical feeling is detected during the movement of one or more of physical feeling and the second physical feeling
Bioelectrical signals in meat.For example, system 1000 can be positioned in the wrist of individual subjects, and electro-physiological sensor
3300 may include the electromyograph (not shown) for being configured to detect the movement in one or more fingers.
In one embodiment, sensor module 1004 include electro-physiological sensor 3300, micro- neural tracer 3306 or
Myograph 3308 is configured to clearly measure the electrical activity mediated by A Delta (A δ) nerve fibre (for example, indicating
Sharp local pain).In one embodiment, sensor module 1004 is traced including electro-physiological sensor 3300, micro- nerve
Device 3306 or myograph 3308 are configured to clearly measure the electrical activity mediated by C nerve fibre (for example, indicating more
Unrestrained property pain, such as pain relevant to inflammation).In one embodiment, electro-physiological sensor 3300, micro- neural tracer
3306 or myograph 3308 be configured as the electrical activity that measurement is mediated by A Delta (A δ) fiber and fiber C, wherein only when
One in A Delta (A δ) fiber or fiber C be sluggish and when one in A Delta (A δ) fiber or fiber C is
When active, one or more sensing signals from sensor module 1004 are transferred to processor 1006.Alternatively, it senses
Device assembly 1004 can send one or more sensings when A Delta (A δ) each of fiber or fiber C are active
Signal, thus processor 1006 is configured as ignoring the corresponding with one in A Delta (A δ) fiber or fiber C of sensing signal
Part.
In one embodiment, biosensor 1012 includes being configured as measurement signal (example relevant to contraction of muscle
Such as, acoustic signal or mechanical signal) myograph (traced for example, EMG 3310, surface EMG 3312, acoustics flesh are dynamic
Sensor 3314, mechanical flesh are dynamic to trace sensor 3316, and accelerometer flesh is dynamic to trace sensor 3318 etc.), wherein being received with muscle
The relevant signal that contracts can indicate the pain status of individual subjects.It traces sensor 3314 for example, acoustics flesh is dynamic and can measure
The sound wave as caused by muscle fibers contract thus determines when that muscle or muscle group are misapplied, causes to ache to assess muscle activity
Pain and damage.
Strain transducer 3320 may include but be not limited to metal laminated strain transducer, silicon nanometer film strain transducer, pressure
Quick resistance strain sensor, bonding metal strain transducer, waveform configuration strain transducer, open mesh structure sensor, mutually
Lock one or more of metal coated nano fiber strain sensor etc..In one embodiment, strain transducer is matched
It is set to the physiological characteristic of measurement physical feeling comprising but be not limited to inflammation, swelling etc..Metal laminated strain transducer can wrap
Include be located at the second metal material on the first metal material, wherein between the first metal material and the second metal material described
Material when being installed to interested surface the material buckles or bending during resistivity between difference the table can be provided
The instruction of the strain of face experience.For example, in one embodiment, metal laminated strain transducer includes titanium/gold lamination (Ti/Au
Lamination), with a thickness of every 60 nanogold, 10 nano-titanium.For the percent strain between about 0.5% and 3.0%, Ti/Au
Lamination can provide the resistance between about 305 ohm and 330 ohm, this can be used for the resistance variations and body of lamination
The strain of position experience is associated.
Silicon nanometer film strain transducer may include thin silicon strip band to provide thin crystalline semiconductor band, and wherein silicon is received
The variation for the relative resistance that rice film is undergone during the bending or bending of silicon when being installed to interested surface can provide surface
The instruction of the strain of experience.For example, in one embodiment, silicon nanometer film strain transducer includes silicon nanometer film, with a thickness of
For about 100nm to about 400nm, width is about 10 μm to about 100 μm, and length is about 100 μm to about 1000 μm.Multiple silicon nanometer film items
Band can be used for strain relevant to physical feeling along different shaft monitorings, such as pass through the longitudinal axis use along physical feeling
Silicon nanometer film simultaneously uses silicon nanometer film (for example, the longest dimension of silicon nanometer film is parallel to phase along the transverse axis of physical feeling
The axis answered).For example, silicon nanometer film can be arranged in array.
Piezoresistance strain transducer may include the material to generate electricity in deformation.In one embodiment, piezoresistance is answered
Become sensor and is included in the material that the midpoint of material (for example, silicon nanometer film, semiconductor material, metal material etc.) is nearby tapered
Material strip band (for example, with offer " dog bone " structure), to provide electricity when undergoing mechanical strain (for example, bending, bending etc.)
The variation of resistance.For example, piezoresistance strain transducer may include the conical silicon nanometer film for being coupled to physical feeling, silicon is received
Electric power caused by rice film is associated with the strain that physical feeling is undergone.In one embodiment, piezoresistance strain transducer
Including lead zirconate titanate (PZT) nanobelt being coupled between gold and platinum electrode, wherein the nanobelt generates electricity in deformation.Example
Such as, in one embodiment, piezoresistance strain transducer includes the lead zirconate titanate nanobelt for being coupled to physical feeling, will be received
Rice is associated with the strain that physical feeling is undergone with generated electric power.
Bonding metal strain transducer may include the metal material on substrate with grid arrangement.Metal material can construct
At filament or foil.In one embodiment, at least part of grid is affixed directly in physical feeling.In experience mechanical strain
When (for example, bending, bending etc.), grid can show the linear change of resistance.For example, in one embodiment, will bond
Metal strain sensor application in physical feeling with the resistance variations of metal grill are related to the strain that physical feeling is undergone
Connection.
Waveform configuration strain transducer may include the relatively brittle waveform configuration material (example being incorporated on flexible support material
Such as, monocrystalline silicon).In one embodiment, waveform configuration material includes the base of substantially flat, in a substantial continuous manner
It is mechanically coupled on flexible support material.In one embodiment, waveform configuration material is in discontinuous bound fraction (example
Such as, at " paddy " of wave) it is mechanically coupled on flexible support material.Waveform configuration material can be micron order or nanoscale knot
Structure (for example, band, film, line etc.), wherein the amplitude of waveform configuration material and wavelength can change in response to mechanical strain.Example
Such as, in one embodiment, the strain transducer of waveform configuration is applied to physical feeling, by the resistance of waveform configuration material
Change associated with the strain that physical feeling is undergone.
The strain transducer of open mesh structure includes the open grid material with grid connection at bridging element,
The plane internal rotation of grid material can be provided when undergoing mechanical strain (for example, bending, bending etc.).It can be by elongation strain
The end of open grid material is applied to cause plane internal rotation at bridging element, this can change the opening in grid
Shape (for example, changing between hollow square and open diamonds).For example, not being aligned with the connecting bridge of open grid material
The strain applied on direction will lead to connecting bridge and rotate around tie point, to provide stretchable strain transducer.Implement one
In scheme, by the strain transducer of open mesh structure be applied to physical feeling, by the resistance variations of open grid material with
The strain of physical feeling experience is associated.
The nanofiber strain transducer of interlocking metal coating may include the nanofiber battle array of interlocking metal coating
Column, each array are supported by baseplate material, to provide interconnection and the electricity of different level between array when applying external strain
Resistance.For example, the nanofiber strain transducer of interlocked metallic coating may include the polymer nano of two high aspect ratio platinum coating
Rice fiber array, each array are supported on thin dimethyl silicone polymer (PDMS) substrate, wherein when applying mechanical strain
When, the degree of nanofiber interconnection and the resistance of sensor are changed in a manner of reversible directionality.It in one embodiment, will be mutual
The nanofiber strain transducer of the metal coating of lock is applied to physical feeling, and the resistance variations of array and physical feeling are passed through
The strain gone through is associated.
In one embodiment, biosensor 1012 includes temperature sensor 3322.For example, temperature sensor 3322 can
To include but is not limited to single point temperature sensor, aerial image temperature sensor and be configured to micro-heating element or actuator
Micro temperature sensor, for example, combine the thin snakelike feature of thin metal or one of the PIN diode with nanoscale film or
Multiple micro temperature sensors.E.g., including the temperature sensor of heat sensor and/or optical sensor can detecte and postpone
Property (for example, after exercise first in 24 hours) breaking-out DOMS (DOMS) (damage of muscle caused by sometimes referred to as moving
Wound) relevant raised tissue temperature (for example, tissue temperature in muscle or proximate skin).
In one embodiment, biosensor 1012 includes acoustic sensor 3338, is configured as measurement physiology thing
One or more acoustic features of part.For example, acoustic sensor 3338 may include at least one microphone or acoustic transducer.Example
Such as, acoustic sensor 3338 can be configured as the joint noise in the arthritis knuckle of detection experience pain relevant to movement
(for example, grabbing sound or bang).For example, acoustic sensor 3338 may include being configured as detection muscle skeleton acoustics
The acoustic sensor (for example, acoustics skin texture sensor 3314) of feature.For example, acoustic sensor 3338 can be configured as detection
Sound event (for example, groan, sounding or voice), such as indicates the sound event of pain.For example, acoustic sensor 3338 can be with
It is configured as detecting the acoustic feature indicated from the physiological event (such as heartbeat, valve closure, blood flow, breathing etc.) of main response.
In one embodiment, biosensor 1012 includes optical sensor 3324, and optical sensor 3324 is configured
For the optical characteristics of the physical feeling where measuring system 1000.In one embodiment, optical sensor 3324 is configured as
Measure blood flow characteristic associated with physical feeling.In one embodiment, optical sensor 3324 is configured as measurement and body
The associated temperature characterisitic of body region.In one embodiment, optical sensor 3324 is configured as measurement and (for example, swollen
In swollen tissue) the relevant pressure of physical feeling, strain or deformation behaviour.In one embodiment, optical sensor 3324 is matched
It is set to measurement heart rate or respiratory rate.In one embodiment, optical sensor 3324 is configured as measurement transmitted light or reflected light
At least one of.For example, optical sensor 3324 can include but is not limited to photodiode, light emitting diode (LED) (example
Such as, light emitting diode 3326), the LED that coordinates with photoelectric sensor (for example, photodetector), fibre optical sensor is (for example, light
Fine beam, fiber bragg grating (Bragg Grating) sensor, fluorescopy sensor etc.), flexible photonic sensor, blood oxygen
Count 3328 (for example, pulse oximetry, near-infrared oximeters etc.), imaging device (such as camera) or combinations thereof.Fibre optical sensor
It may include intrinsic fibre optical sensor (for example, fibre optical sensor represents sensing element) and external fiber sensor (for example, light
Conveyer, characteristic by will be influenced by the received measured variable of individual detector (measurand) or modulation) and can
To provide the measurement to physical parameter, physical parameter is such as, but not limited to temperature, power, torque, strain, position etc..Implement one
In scheme, fibre optical sensor is configured for measurement one or more of heart tissue or respiratory tissue, such as sensing
The temperature that may be used as pain indicator of respective organization, strain, deformation (for example, swelling).For example, fibre optical sensor (for example,
Single fiber line, multiple optical fiber cables in parallel, multiple optical fiber cables in matrix, helical configuration, honeycombed configuration or other configurations
Deng, or combinations thereof) can be for example supported by fabric, band or silk ribbon relative to physical feeling, it thus can from the light that optical fiber issues
To be collected by controller as (for example, from physical feeling, from fabric etc.) reflection or transmitted light to determine its light feature
(for example, wavelength, intensity etc.).Comparison between these features in different time periods can provide the physiology about physical feeling
The instruction of the variation of state, such as provided via temperature change, strain, metaplasia etc..In one embodiment, optical sensing
Device 3324 includes one or more photoelectron devices, with based on one or more physical features to individual subjects measurement or
Sensing is to generate one or more sensing signals.For example, photoelectron device may include but be not limited to one or more polymer hairs
Optical diode (PLED), one or more organic photodetectors (OPD) or combinations thereof.In one embodiment, photoelectron fills
The light that transmitting different wave length is configured as including multiple polymer LEDs (PLED) is set (for example, green light, feux rouges, indigo plant
Light etc.), with one or more organic photodetectors (for example, having poly- (3- hexyl thiophene) (P3HT): (6,6)-phenyl-
C61- methyl butyrate (PCBM) active layer) combination be arranged to super flexible reflected impulse oximeter.
In one embodiment, biosensor 1012 includes near infrared sensor 3300, is configured to measurement body
The physiological characteristic of position, such as, but not limited to tissue oxygenation, blood analyte, for example, oxygen, carbon monoxide, ferrihemoglobin,
Total hemoglobin, glucose, protein or lipid, or measurement brain activity (prefrontal cortex activity relevant to nociception).
For example, related with the activation of neuroceptor and pain increase by the hypoxemia in the detectable muscle of NIR Oximetry.
For example, biosensor 1012 can measure the oxygenation in ear-lobe, such as by being configured to substrate 1002 to surround ear-lobe
Or the other parts of ear measure, thus biosensor can pass through transmissivity measurement oxygenation.For example, by blood oxygen
What meter 3328 detected causes the skin blood flow of hypoxemia or ischaemic to reduce the finger that can be pain or pain risk
Sign is associated, and the pain is for example from pressure sore.In one embodiment, pressure sensor 3342 is configured as sensing body
The swelling associated with pain of the possibility of body region is one or more of stiff.For example, biosensor 1012 or processing
At least one of device 1006 includes the circuit for being configured to determine that physical feeling ischemic risk, and the determination is for example by comparing
One or more (for example, from pressure sensor 3342 or other biosensors) sensing signals and indicate ischemic risk
The reference data of the factor carries out.For example, at least one of biosensor 1012 or processor 1006 include being configured as really
Surely be applied to the circuit of the risk of the chronic stress in physical feeling, the determination for example by comparing it is one or more (for example,
From pressure sensor 3342 or other biosensors) sensing signal and indicate the reference numbers of the risk factors based on pressure
According to progress.In one embodiment, pressure sensor 3342 can use pressure (for example, passing through mechanical probes) or electric signal
One or more of (for example, passing through Electrode Operation) stimulates physical feeling, has with pain to measure the possibility of physical feeling
The tenderness of pass is tetanic.
In one embodiment, biosensor 1012 be configured as detection indicate autonomic nerves system response one or
The variation of multiple physiological parameters, including but not limited to biopotential, electricity physiological signal, heart rate, heart rate variability, arterial pressure,
The variation of plethysmograph wave amplitude, skin conductivity level, skin conductivity fluctuation number and its time-derivative etc..Including biotic potential and
The variation of autonomic nerves system including the variation of electricity physiological signal can be used as index existing for pain.For example, ECG 3302
It is configurable to measurement heart rate variability;The reduction of heart rate variability power in high frequency band (i.e. 0.15-0.4Hz) can be with table
Show panic attacks.It is received for example, oximeter 3328 (for example, pulse oximetry or light plethysmograph) can be configured to assessment blood vessel
Contracting;Caused and can be indicated by light-plethysmographic waveform amplitude reduction that oximeter 3328 detects by peripheral blood vessel contraction
Pain.For example, skin conductance sensor 3320 can be configured to the variation of detection skin conductivity;It can be fluctuated by skin conductivity
Level and the variation of quantity can indicate pain come the variation of plating (electro-galvanic) skin properties measured
In the presence of.For example, surface EMG 3312 can be configured to the variation of bioelectrical signals in detection superciliary corrugator muscle;Drawn by autonomic nerves system
The variation for the muscle tone led can indicate the presence of pain.
In one embodiment, one or more of sensor module 1004 or processor 1006 can be configured as from
The signal detected is included in for example, extracting information in the electricity physiological signal detected to handle, analyze, receive or to transmit
The subset of all information in signal detected.For example, ECG 3302 can capture the electricity physiological signal from heart, and
The signal includes can be with the feature of such as heart rate, eartbeat interval and heart rate variability of independent evaluations etc;For example, heart rate variability
The reduction of property can indicate panic attacks.For example, EMG 3312 can capture the signal from superciliary corrugator muscle, and the signal includes
It can be with features such as the amplitude of independent evaluations, frequencies;For example, the amplitude of EMG signal and the variation of entropy can indicate the presence of pain.
In one embodiment, one or more biosensors 1012 are configured as combining two or more physiology ginseng
Number (for example, autonomous response parameter) simultaneously provides single multi-parameter sensing signal.In one embodiment, one or more physiology pass
Sensor 1012 is configured as providing the signal about two or more physiological parameters to processor 1006, and processor 1006
Information is combined into single multi-parameter signals.In one embodiment, system 1000 is configured as more ginsengs of assessment autonomic signals
Number is compound to determine instruction existing for pain.In one embodiment, biosensor 1012, which is configured as detection, indicates autonomous
The variation of one or more physiological parameters of response in nervous system, for quantifying pain status.For example, biotic potential and
The variation that quantifies of electricity physiological signal can be used as the index of pain intensity.For example, being measured by skin conductance sensor 3320
Higher skin conductivity level can indicate high-intensitive pain.
In one embodiment, biosensor 1012 includes the chemical sensor 3340 for being configured to measurement analyte,
In this analyte can indicate the pain status of individual subjects.In one embodiment, chemical sensor 3340 may include
For detecting the sensor of the analyte in sweat.For example, chemical sensor 3340 may include for detecting the sugar in sweat
The increased sensor of level of class (such as glucose), salt (such as lactate or glutamate).For example, chemical sensor 3340
It may include the sensor for detecting hormone (such as cortisol or adrenaline).For example, chemical sensor 3340 may include using
In detection inflammatory mediator (for example, prostaglandin (for example, PGE2), bradykinin, thrombocytin, atriphos, pyruvic acid etc.) or
The sensor of proinflammatory cytokine (IL-1 α, IL- β, IL-6, TNF α, IL-8).For example, chemical sensor 3340 may include being used for
Detect the sensor of pH variation.For example, chemical sensor 3340 may include for detect ion or electrolyte (for example, hydrogen, sodium,
Potassium, chlorine, calcium, magnesium, phosphate etc.) sensor.In one embodiment, chemical sensor 3340 is included in poly- pair of mechanical flexibility
The multichannel perspiration sensor array manufactured on ethylene terephthalate (PET) substrate.Multichannel perspiration sensor array may include
Amperometric glucose sensor, current mode lactate sensor or combinations thereof may include being fixed on silver/silver chlorate (Ag/
AgCl) glucose oxidase in the permeable membrane (for example, polysaccharide chitosan film) of electrode and lactate oxidase are to promote reference
Electrode and to electrode be used for the amperometric glucose sensor, current mode lactate sensor or combinations thereof.Sensor can be with
Generate and the metabolin (such as glucose, lactate etc.) between working electrode and silver/silver chloride reference electrode abundance at than
The current signal of example.Multichannel perspiration sensor array can additionally or alternatively include the ion selectivity with reference electrode
Electrode (for example, for measuring sodium and potassium level), may include the electrode of polyvinyl butyral (PVB) coating.Multichannel sweat
Liquid sensor array can include additionally or alternatively temperature sensor, including but not limited to based on the temperature sensor of resistance
(for example, by insulating layer, such as chrome gold (Cr/Au) microfilament of parylene layer support).In one embodiment, chemistry passes
Sensor 3340 includes the perspiration sensor based on graphene, with snakelike golden net and golden doped graphene (for example, passing through chemistry
The golden doped graphene of vapor deposition (CVD) manufacture) it is double-deck.Perspiration sensor based on graphene can also include waterproof membrane
(for example, silicone layer), humidity sensor (for example, poly- (3,4- Ethylenedioxy Thiophene electrode), glucose sensor (for example,
The transfer sensor of charge based on Prussia (Prussian) indigo plant), pH sensor (for example, polyaniline), to electrode (for example,
Ag/AgCl), tremble sensor (for example, graphene), sweat absorbed layer (for example, Nafion layers), or combinations thereof.For example, chemical
Sensor 3340 may include for detecting the protein in sweat (for example, proinflammatory cytokine, inflammatory mediator, hormone etc.)
Or the sensor of its peptide.In one embodiment, chemical sensor 3340 may include for sensing tissue fluid (for example, blood
Liquid) in analyte transdermal sensor.For example, chemical sensor 3340 may include being configured to Reverse iontophoresis therapy
The sensor of (for example, Reverse iontophoresis extraction), to extract analyte (for example, glucose) from clearance space without piercing through
Skin.For example, chemical sensor 3340 may include the micropin for entering in organization space.
Chemical sensor 3340 can contribute to determine the pain status of individual subjects.For example, plysiochemical substance water
Flat variation and the increase that muscle uses or that there are pain conditions is related.For example, in sweat or bodily tissue (for example, interstitial group
Knit) in measurable lactate level or glucose level (for example, hormone of response release) increase and the increase that uses of muscle
Or pain there are related.For example, in response to pain release one or more hormones (for example, cortisol, pregnenolone,
DHEA, corticotropin (ACTH), capture amine (for example, adrenaline or norepinephrine) testosterone, progesterone, it is female swash
Element, thyroid releasing hormone (TRH), trilute (T3), thyroxine (T4)) increased level can be in sweat
Or it is measured in other body fluid.For example, in response to neuropeptide (such as neuropeptide tyrosine, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 and the calcitonin gene phase of pain release
Close peptide (CGRP)) or other neurotransmitters (such as glutamate) can be measured in sweat or other body fluid.For example, pain (example
Such as, tenderness, allodynia and hyperalgia) pass through such as bradykinin discharged during movement or exercise and PGE 2 etc
Endogenous mediator and it is related to the sensibility of muscular injuries receptor.For example, atriphos (ATP) and electrolyte level
Increase or uneven and low pH usually may be related with the pain increase that individual subjects are undergone;ATP and hydrogen ion are to pass through
The stimulant of nerve endings is activated in conjunction with acceptor molecule, and the pathology of skeletal muscle and Pathological Physiology variation are along with pH
Decline.For example, tissue metabolism's increase causes oxygen level to reduce (can detect by oximetry) during movement, cause under pH
Drop and hydrogen atom accumulation (as above detectable), this can activate nerve endings to cause pain in turn.For example, muscle cramp (is held
Continuous, involuntary contraction of muscle) along with muscle ischemic, this leads to pH decline and algesiogenic substance such as bradykinin, ATP
With hydrionic release.For example, electrolyte level change may in the activation of nociceptor ion channel (for example,
Transient receptor potential family member) it is related.
In one embodiment, chemical sensor 3340 includes electrochemical sensor.For example, electrochemical sensor can wrap
Include but be not limited to: current enzyme electrode detects glucose or lactate oxidase using glucose oxidase to detect lactic acid;
Or one or more ion selective electrode (for example, potentiometer), it can detecte electrolyte (such as sodium, potassium) and can be used for
PH monitoring.In one embodiment, electrochemical sensor utilizes Reverse iontophoresis therapy.For example, electrochemistry may include
Pairs of Reverse iontophoresis therapy electrode (for example, Ag/AgCl), reference electrode (Ag/AgCl) and working electrode is (for example, general
Shandong scholar is blue), selective amperometry biological sensing (for example, being handled with glucose oxidase) can be modified for.One
In embodiment, electrochemical sensor includes ligand, such as aptamer.For example, gold nano grain/aptamer modified electrode can be used for
Detect protein.In one embodiment, chemical sensor 3340 is transmitted including miniflow figure fluid, such as logical by microfluid
Road (for example, formed in substrate 1002 or other supporting substrates or formed by substrate 1002 or other supporting substrates).For example, micro-
Interested analyte can be transported to the detector on substrate 1002 from physical feeling by fluid channel, or for system
1000 accommodate for subsequent remote analysis.In embodiments, system 1000 may include one in algometer or algometer
It is a or multiple.For example, biosensor 1012 may include one or more of algometer or algometer, (for example, passing through
The operation of algometer or algometer, compared with independently of the operation of algometer or algometer pain experienced etc.) provide pass
In the instruction of the pain of individual subjects experience.
Processor 1006 is configured as reception (for example, from sensor module 1004) and examines with by motion detector 1010
One of individual subjects where the movements of parts of the body that measures or the system 100 detected by biosensor 1012
Or the associated one or more sensing signals of one or more of multiple physiological parameters, and provide and one or more is sensed
The analysis of signal.For example, processor 1006 is a including being configured as identifying based on the analysis to one or more sensing signals
The circuit of the physiological status (for example, pain status) of body subject.In one embodiment, processor 1006 includes being configured as
Identify the physiological status of individual subjects (for example, pain based on the movements of parts of the body detected by motion sensor 1010
Pain state) circuit.In one embodiment, processor 1006 includes being configured as based on by one or more biosensors
The 1012 one or more physiological parameters detected identify the electricity of the physiological status (for example, pain status) of individual subjects
Road.In one embodiment, processor 1006 includes being configured as based on the physical feeling detected by motion sensor 1010
Movement and each of one or more physiological parameters for being detected by biosensor 1012 identification individual subjects
The circuit of physiological status (for example, pain status).For example, in one embodiment, processor 1006 is operatively coupled to pass
Sensor component 1004 so that processor 1006 be configured as one from motion detector 1010 or biosensor 1012 or
The one or more sensing signals of multiple receptions.
In one embodiment, as shown in figure 12, system 1000 includes the comparison module that can be accessed by processor 1006
1300, the movements of parts of the body that is detected with the motion sensor 1010 compared by sensor module 1004 or by sensor
One in the one or more physiological parameters for the physical feeling that one or more biosensors 1012 of component 1004 detect
Person or more persons and the reference data for indicating physiological status.In one embodiment, physiological status includes pain status, pain class
At least one of type, pain level or pain quality.For example, reference data may include exercise data or physiological parameter data
One or more of, wherein such data can be associated with pain status, but it is not limited to, pain associated with pain status
Pain state such as non-pain state, panic attacks, PAIN MODEL, chronic ache, Acute Pain, Combination pain status, pain sensation mistake
Quick property pain status, allodynic state, breakthrough pain state, neuropathic pain states, nociceptive pain state, non-injury
Property pain status, a combination thereof or similar state.For example, reference data may include motion reference data or physiological reference data
One or more of, the motion reference data indicate movements of parts of the body function short-term or change in long term (for example, by
Increase or inhibit muscle activation in the physiological adaptability to Acute Pain or chronic ache), protection act, funny face, clumsiness step
State, limping, the redistributing of activity or pressure, the change of load, obviously using non-advantage limbs, influence physical feeling (for example,
Muscle) movement or excitement it is obvious minimize, the obvious friction of physical feeling or massage (for example, repetition or deep massage),
Force production reduce, lack using physical feeling, respiratory dysfunction, using clamping plate, it is involuntary reaction (for example, reflection, convulsion
Contraction etc.) etc., or combinations thereof, the physiological reference data include but is not limited to heart rate (including indicate pain heart rate variation or
The variation of heart rate), blood pressure (including indicate pain blood pressure), electric physiological data (including but not limited to the electrical activity of heart,
The electrical activity (for example, cornea-retina normality current potential, pupil diameter etc.) of eyes), nerve impulse, musculoskeletal pressure or electricity
Activity (the including but not limited to current potential, musculoskeletal acoustics of muscle cell generation or mechanical property (for example, vibration) etc.) is answered
Parameter according to (for example, related to muscle), temperature (including indicate pain temperature change), blood oxygen data (including expression pain
Blood oxygen variation), skin conductivity data (variation including indicating the skin conductivity of pain), bioimpedance data (including table
Show the variation of the bio-impedance of pain), pH data (including indicate pain pH value variation or chemical data (including indicate pain
The variation of the chemical analyte concentration of pain), the chemical data includes but is not limited to sweat analyte, tissue analyte, carbohydrate
(such as glucose), salt (such as sodium chloride), lactate, electrolyte (such as sodium, chloride, potassium etc.), hormone (such as cortex
Alcohol, adrenaline, pregnenolone, DHEA, testosterone, progesterone, estrogen, triiodo thryonine (T3) and thyroxine
(T4)), neuropeptide (such as neuropeptide tyrosine, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 and calcitonin gene-related peptide (CGRP)), peptide, protein or nucleotide or through repairing
The nucleotide (for example, atriphos) of decorations, inflammatory mediator (for example, prostaglandin (for example, PGE2), bradykinin, thrombocytin,
Atriphos, pyruvic acid etc.), proinflammatory cytokine (IL-1 α, IL- β, IL6, TNF α, IL-8) or it is provided herein other
Movement or physiological factor.In one embodiment, reference data may include exercise data associated with types of pain or life
Manage one or more of supplemental characteristic, wherein such data can with nociceptive pain (for example, due to mechanical, heat and/or
Or chemical interaction causes), body pain, neuropathic pain, splanchnodynia, superficial pain and psychogenic pain it is associated, but
It is not limited to associated with these.In one embodiment, reference data may include exercise data associated with pain level
Or one or more of physiological parameter data, wherein such data can be with pain intensity, pain severity or pain journey
Degree is associated, but is not limited to associated with these.In one embodiment, reference data may include and pain quality or pain
One or more of the associated exercise data of quantity or physiological parameter data, wherein such data can be with the master of pain
It is associated (such as subjective special with those of being identified by individual subjects to see feature (for example, subjective pain threshold value or tolerance threshold)
Sign is associated), but be not only restricted to associated with these.Types of pain can also include spontaneous pain (for example, not stimulating
In the case where occur), caused pain (for example, occurring in response to stimulation), constant pain or intermittent pain.One
In embodiment, motion sensor 1010, biosensor 1012 or combinations thereof may include for assessing by individual subjects
The stimulator of caused reaction.For example, stimulator may include egersimeter, caloric stimulator, photic stimulator etc..Types of pain may be used also
Including head pain or headache, tension headache, cervical headache, migraine or combinations thereof may include but be not limited to.
In one embodiment, reference data may include the specific threshold value of user or tolerance information.For example, when a body-sensing
When to pain, individual can (for example, passing through user interface 3600 as described herein) indicated to system 1000.Then, system
1000 can shoot the snapshot of one or more of physiological status, motion state, location status of individual etc., threshold value is arranged
Pain level, physiology or kinematic parameter is associated with the pain of Individual Experience, etc., it can be used as oneself of personal story
The comparator of principal parameter.Whether system 1000 can be aggravated with monitoring individual and reception about pain, if be dissipated, if in class
The different other individual input of type, position, chronology (chronology) etc..
In one embodiment, processor 1006 is configured in response to correspond to individual subjects pain shape experienced
The physiological status of state and activation effect device 1008 are to influence physical feeling.For example, system 1000 can (by processor 1006,
Sensor module 1004 or combinations thereof) identify the physiological status of individual subjects, wherein corresponding to the physiology of specific pain status
State is used as the trigger that physical feeling is treated to activation effect device 1008 of processor 1006.For example, processor
1006 can be compared physiological status with activation effect device 1008 with the reference data for indicating trigger condition, wherein this touching
Clockwork spring part can be specified pain status, the pain status include but is not limited to non-pain state, panic attacks, PAIN MODEL,
Chronic ache, Acute Pain, Combination pain status, Hyperalgesic pain state, allodynic state, breakthrough pain shape
State, neuropathic pain states, nociceptive pain state, non-nociceptive pain state, a combination thereof.In one embodiment, it handles
Device 1006 be configured in response to correspond to individual subjects experience pain level, individual subjects experience types of pain,
The physiological status of the pain quality of individual subjects experience or combinations thereof carrys out activation effect device 1008.For example, processor 1006 can
Being compared physiological status with the reference data for indicating trigger condition with activation effect device 1008, wherein this trigger condition
It can be specified pain level, types of pain or pain quality comprising but nociceptive pain is not limited to (for example, due to machine
Tool, heat and/or chemical interaction cause), body pain, neuropathic pain, visceral pain, facial pain, psychogenic pain,
It is intensity, the seriousness of pain, the degree of pain, myofasical pain syndrome or the illness of pain, acutely degree, dullness, scorching hot, cold
Cold, tenderness itch, spasm, radioactivity, tingling, palpitates from nervousness, pain, fatigue, depth, trembles or shock by electricity, stabs etc. and its group
It closes.In one embodiment, processor 1006 is configured in response to from biosensor 1012 about in physical feeling
Pain position information and activation effect device 1008 to influence physical feeling.For example, processor 1006 may be in response to from one
A or multiple EMG 3310 or surface EMG 3312 to determine specific muscle (for example, anatomically or in history known
Muscle) in cause the information of the activation of regional pain to carry out activation effect device 1008.For example, processor 1006 can be in response to coming
From indicating which muscle is undergoing the subset of two or more EMG 3310 or surface EMG 3312 sensor of pain
Information carrys out activation effect device 1008.
In one embodiment, processor 1006 accesses comparison module or reference by access computer storage 1302
One or more of data, computer storage 1302 can include but is not limited to random access memory (RAM), read-only deposit
Reservoir (ROM), electrically erasable programmable read-only memory (EEPROM), flash memory or other memory technologies, CD-ROM, number
General optic disc (DVD) or other disc memories, cassette, tape, magnetic disk storage or other magnetic storage devices can
For storing being safeguarded by comparison module 1300 or memory manager and can be set by processor 1006 or other correlation access
Any other medium of the information needed of standby access.
Processor 1006 includes for handling one or more sensing signals from sensor module 104 and to system
1000 one or more components (such as effector 1008) provide the component of instruction.For example, processor 1006 may include micro- place
Manage device, central processing unit (CPU), digital signal processor (DSP), specific integrated circuit (ASIC), field-programmable gate array
Arrange (FPGA) etc., or any combination thereof, and may include discrete digital or analog circuit element or electronic device, or combinations thereof.
In one embodiment, processor 1006 includes one or more ASIC with multiple predefined logical blocks.Implement one
In scheme, processor 1006 includes one or more FPGA with multiple programmable logic orders.Computer memory device can
, can be associated with external equipment with integrated with system 1000, and wirelessly or non-wirelessly communication protocols can be passed through by system 1000
View or combinations thereof accesses.For example, reference data can be by being coupled to the computer storage of the substrate 1002 of system 1000
1302 storages (such as can pass through telenet by another method by processor 1006 via radio apparatus access
Network, cloud network etc.) it can be used for processor 1006, or combinations thereof.In one embodiment, as shown in figure 33, processor 1006 wraps
Receiver 3400 or transceiver 3402 (for example, antenna etc.) or combinations thereof are included or are operatively coupled to, to pass through wireless or have
Line communication protocol receives reference data information or other information (for example, corresponding threshold information, programming information), with promotion system
1000 operation or control.For example, receiver 3400 can receive one or more signals of communication from external equipment 3406, it is external
Equipment 3406 with but be not limited to control programming, reference data, inquiry (for example, be used for from system 1000 to external equipment 3406
It sends the inquiry of information, the inquiry of motion state for determining individual subjects, work as previous existence for determine individual subjects
The inquiry etc. of reason state (for example, pain status)), or combinations thereof it is associated.In embodiments, processor 1006 can add
Ground includes alternatively transmitter 3404 or transceiver 3402 (for example, antenna etc.), to send between the component of system 1000
Information sends information to the component of exterior, such as communicates with external equipment 3406.This communication may include example
Such as, processor 1006 is accessing one or more databases of storage reference or programming data, calculating agreement, system update etc.
Or the instruction of memory devices.External equipment 3406 may include in receiver 3408, transceiver 3410 or transmitter 3412
One or more, to promote the component communication with system 1000.It is set for example, external equipment 3406 can include but is not limited to communication
Standby or electronic equipment, such as one or more of mobile communication equipment or computer system comprising but be not limited to one or
Multiple mobile computing devices are (for example, hand-portable computers, personal digital assistant (PDA), laptop computer, net book
Computer, tablet computer etc.), mobile telephone equipment (for example, cellular phone and smart phone) including with smart phone peace
The equipment of plate computer (for example, plate) associated function, wearable or portable device (e.g., including with system 1000
In the sensor in identical physical feeling, the sensor, tested far from individual that is located at from system 1000 in different physical feelings
Sensor, the sensor on Different Individual subject etc. of person's positioning), portable gaming device, portable media play
Device, multimedia equipment, enhancing or virtual reality (VR) system (for example, VR headphone, VR immersion experiencing system), satellite
Navigation equipment (for example, global positioning system (GPS) navigation equipment), eBook reader device (electronic reader), intelligence electricity
Equipment (for example, desktop computer), personal computer (PC) equipment are calculated depending on (TV) equipment, surface and use the people based on touch
The other equipment at machine interface.System 1000 and external equipment 3406 can via receiver 3400,3408, transceiver 3402,
3410 and transmitter 3404,3412 communicate (for example, sending and receiving signal of communication) each other, such as pass through one or more
Wired and wireless communication mechanism communicates each other, the wired and wireless communication mechanism include but is not limited to sound communication signal,
Optic communication signal, wireless communication signals, Infrared communications signals, supersonic communication signal etc..In one embodiment, system 1000 can
Using using the communication from external equipment 3406 as pilot guide (for example, when joining effect device 1008, when start through
It is sensed etc. by sensor module 1004).
Processor 1006 sensing signal can coordinate the operation of system 1000 and based on one or more based on one or more
The physiological status (for example, pain status) of a sensing signal identification individual subjects.For example, processor can be based on identifying
The situation of physiological status (for example, pain status) and the individual subjects experience of individual subjects is (for example, resting state, movement
State etc.) carry out the operation of coordinating effect device 1008.Effector 1008 is operatively coupled to processor 1006, and in response to place
It manages the control of device 1006 and is configured to influence the physical feeling of individual subjects.In one embodiment, as shown in figure 34, effect
Device may include but be not limited to ultrasonic transducer 3500, electrode 3502, magnetic stimulator 3504, photic stimulator 3506, caloric stimulator
3508, the acoustic stimulator 3510, mechanical stimulator 3512, vibratory stimulation device 3514 or combinations thereof.
Ultrasonic transducer 3500 generate be directed to individual subjects physical feeling ultrasonic wave (or signal), such as
Treat physical feeling.In one embodiment, effector 1008 includes ultrasound transducer array.For example, effector 1008 can wrap
The first ultrasonic transducer and the second ultrasonic transducer are included, the first ultrasonic transducer is configured to be placed on the body of individual subjects
On first position on position, the second ultrasonic transducer is configured to be placed on the second position in the physical feeling of individual subjects
On.Ultrasound transducer array can the different location based on energy converter, the different moulds based on the ultrasonic wave generated by ultrasonic transducer
Formula etc. provides local treatment.In one embodiment, ultrasonic transducer 3500 be configurable to generate low-intensity ultrasonic (for example,
Low-intensity treats ultrasonic (LITUS);Low-intensity, long duration ultrasonic therapy).For example, ultrasonic transducer 3500 can produce
About 30mW/cm2To about 1000mW/cm2Ultrasonic wave, wherein this low-intensity can be applied to the physical feeling of individual subjects
Up to most about 8 hours.As another example, ultrasonic transducer 3500 may include diverging wave transducer, about 2.5 to about
With about 0.03W/cm under the frequency of 3MHz2To about 2W/cm2Ultrasound intensity operation, the treatment continuously less than about 18 hours.One
In embodiment, low-intensity ultrasonic corresponds to the about 90mW/cm at energy converter planar2Space time mean intensity, wherein 1 is small
When treat to physical feeling the ultrasonic energy of about 1795J be provided, and wherein treatment in 6 hours for physical feeling provides about 9596J
Ultrasonic energy.In general, bigger sound, which can deposit, can provide better clinical effectiveness, wherein it has been found that each treatment
Phase average deposition 4228J provides clinically significant as a result, and being deposited without for average 2019J is provided relative to control or dummy treatment
Statistics or clinically significant difference.In one embodiment, ultrasonic transducer 3500 includes that power controller and two are super
Sonic transducer, each energy converter have the frequency of 3MHz, 0.132W/cm2Intensity, so that the treatment phase for 4 hours provides about
The accumulation ultrasound energy deposition of 18720J.In one embodiment, ultrasonic transducer 3500 includes divergent lens, by ultrasonic wave
Scatter to diverging acoustic therapies region.In one embodiment, ultrasonic transducer 3500 is configurable to generate high-strength focused super
Sound wave (for example, HIFU).For example, ultrasonic transducer 3500 can produce about 2.5 to about 3MHz, about 1900W/cm2To about
2810W/cm2, for about the high-intensity focusing ultrasonic wave of 3 to about 15 seconds duration.In one embodiment, high-intensitive poly-
Burnt ultrasonic wave can provide nerve block.1000W/cm is greater than about in strength level2When, treatment can lead to the office in tissue
Portion's coagulation necrosis and structure are destroyed, so that biological effect can be limited to by the focusing therapy region of HIFU ultrasonic transducer 3500
The specific targeting regions of physical feeling are to be treated (for example, to provide nerve block etc.).In one embodiment,
Focusing therapy region is about 1mm × 10mm.In one embodiment, effector 1008 includes imaging device, in order to target body
The targeting regions of body region.Imaging device may include that the ultrasonic imaging of the wideband frequency for example with about 5MHz to about 10MHz is changed
Energy device, to provide high echogenic area domain in the focal point of ultrasonic transducer 3500 with during ultrasonic imaging energy converter simultaneously operating,
This can be convenient for via bright or light regional observation targeting regions.In one embodiment, ultrasonic transducer 3500 is configured to generate
Low dosage, high frequency ultrasound.For example, ultrasonic transducer 3500 can produce the frequency of about 1MHz, about 0.5 to about 3W/cm2,
The low dosage high-frequency ultrasonic that pulse pattern is about 1:4.In one embodiment, the treatment of low dosage, high frequency ultrasound continues
Time includes treating for daily five minutes, for about 20 courses for the treatment of.In one embodiment, ultrasonic transducer 3500 is about 8MHz's
With about 0.15W/cm under frequency2The period of operation about 15 seconds, duty ratio is about 0.01%, and targeting regions are cortex after volume.
In one embodiment, ultrasonic transducer 3500 is under the frequency of about 0.5MHz with about 5.9W/cm2Operation about 500 milliseconds when
Section, duty ratio is about 36%, and targeting regions are main somatic cortex S1.In one embodiment, ultrasonic transducer
3500 under the frequency of about 0.25MHz with about 0.3W/cm2To about 2.5W/cm2The period of about 300 milliseconds of operation, duty ratio are about
50%, and targeting regions are main somatic cortex S1.In one embodiment, ultrasonic transducer 3500 be configured as with
Based on pulse, ultrasonic signal is generated based on continuity or combinations thereof.
In one embodiment, ultrasonic transducer 3500 is configured as according at least the first treatment mode and the second treatment mould
Formula generates ultrasonic signal.Treatment mode can be related to spatial model (for example, the depth for changing the position for the treatment of, changing treatment
Deng), timing mode, intensity mode etc..For example, in one embodiment, processor 1006 is based on dynamically according to the first treatment
Mode and the second treatment mode instruction ultrasonic transducer 3500 alternately produce ultrasonic signal.In one embodiment, the first treatment
Mode and the second treatment mode according to the target site of the physical feeling of individual subjects (for example, the position on body or limb,
Such as the position on skin surface) or at least one of the target depths of physical feeling of individual subjects and it is different.One
In embodiment, ultrasonic transducer 3500 generates ultrasonic signal according to multiple supersonic frequencies, wherein can be in response to processor
1006 or the control of internal ultrasonic transducer controller tune or adjust frequency.In one embodiment, effector 1008 wraps
Include the first ultrasonic transducer 3500 and the second ultrasonic transducer 3500, the first ultrasonic transducer 3500 be configured to be placed on individual by
On first position in the physical feeling of examination person, and the second ultrasonic transducer 3500 is configured to be placed on the body of individual subjects
On the second position on position.For example, the first ultrasonic transducer 3500 and the second ultrasonic transducer 3500 can be relative to one another
Be spaced apart (for example, in different physical feelings, in the different zones of identical physical feeling, in identical physical feeling
Opposite side on etc.), wherein energy converter can receive different source frequencies with to individual subjects provide treatment.
In one embodiment, photic stimulator 3506 is configured to generate infrared light.For example, photic stimulator 3506 can produce
Infrared light as low intensity pulse infrared light.In embodiments, photic stimulator 3506 generates about 0.3 to about 0.4J/cm2's
Light, than the threshold value of histological tissue damage can occur (for example, about 0.8 to about 1.0J/cm2) about 2.5 times small.Optical stimulation device
3506 may include laser to promote to treat, and wherein laser may include but be not limited to holmium: YAG laser (2.12 μ
M), free electron laser (2.1 μm), alexandrite laser (750nm), solid-state laser (1.87 μm) or combinations thereof.One
In embodiment, photic stimulator 3506 generates light so that about 6 to about 10 degrees Celsius of skin surface temperature increase is (for example, with to week
It encloses nerve and stimulation is provided).For example, processor 1006 can guide photic stimulator 3506 to generate light to provide from instantaneous tissue heating
Photo-thermal effect (for example, there is the temperature gradient mediated in about 3.8 to about 6.4 degrees Celsius of time of aixs cylinder level and space).
In one embodiment, effector 1008 and its stimulation are (for example, vibratory stimulation, ultrasound stimulation, mechanical stimulus, light
Learn stimulation, electro photoluminescence etc.) proprioceptor, mechanoceptor or light touch receptor can be engaged;Stimulate this nerve that can produce
The raw feeling to nervous system, competes with the signal from nociceptor (for example, nociceptor), to reduce individual
Pain nerve perception.In one embodiment, effector 1008 and its stimulation can engage the body in ear or on ear
Position (for example, vagal stimulation).In one embodiment, effector 1008 and its stimulation can engage one or more fleshes
Fascia trigger point.
In one embodiment, processor 1006 is configured as being in resting state (for example, sleeping when individual subjects
Be seated whens feeling, read, seeing TV or other electronic equipments etc., prostrate etc.) when activation effect device 1008.For example, effector 1008
It may include ultrasonic transducer 3500, ultrasonic transducer 3500 is configured to provide for high power pain threshold ultrasound
(HPPTUS), so that potential muscular fascia trigger point desensitization is (for example, cause the pathologic of the muscle fibre of part and referred pain
Change, and do not cause spontaneous local pain) to carry out pain therapy.In one embodiment, multiple HPPTUS are applied
It is applied to physical feeling (for example, when individual subjects are motionless or rest) during treatment.For example, the quantity of HPPTUS application can
To include but is not limited to 3 to 10 treatments at potential muscular fascia trigger point.For example, single HPPTUS application may include but unlimited
In with the 0.5W/cm of 1MHz2To 1.2W/cm2Continuous wave apply ultrasonic energy about 5 minutes.
In one embodiment, as shown in figure 35, system 1000 further includes user interface 3600.User interface 3600 can be with
Processor 1006 is operatively coupled to the operation of promotion system 1000.For example, in one embodiment, processor 1006 can
It is operatively coupled to user interface 3600, and is configurable to generate one or more signals of communication so that user interface 3600 is aobvious
Show.Signal of communication for display may include the request for example inputted about the user of the mode of operation of effector 1008.For example,
System 1000 can seek the approval of user (for example, individual, health care professionals etc. where system 1000) or not criticize
Standard comes certain functions of operating system, the including but not limited to function of effector 1008.In one embodiment, processor 1006
It is configured to respond to prevent the activation of effector 1008 via the user command of user interface 3600.For example, processor
1006 can show the request for the user's input that whether should be activated about effector 1008 with indicative user interface 3600.User can
With selection refusal activation command to prevent effector 1008 from activating at this moment.In one embodiment, processor 1006 is configured
To carry out activation effect device 1008 in response to the user command via user interface 3600.For example, processor 1006 can indicate to use
The request for the user's the input whether display of family interface 3600 should activate about effector 1008.User can choose activation or make
Obtaining activation command can allow effector 1008 to activate at this moment, or scheduling enables time or the movement shape of the activation of effector 1008
State.For example, individual can guide user command with the only activation effect device 1008 during rest by user interface 3600, such as
The activation effect device 1008 when individual subjects are by sleep or rest.User interface 3600 may include but be not limited to graphical user circle
Face (GUI), touch screen component (for example, capacitive touch screen), liquid crystal display (LCD), light emitting diode (LED) display or
Display based on projection, or combinations thereof.
In one embodiment, as shown in figure 36, system 1000 includes being operatively coupled to effector 1008, processor
1006 or combinations thereof timer 3700.In one embodiment, processor 1006 is configured to respond to the treatment of effector
Duration and the activation for stopping effector 1008.For example, the accessible maximum reference time duration (example of processor 1006
Such as, store in memory 1302, can be accessed in other words by processor 1006), thus processor 1006 can compare by
The treatment time that timer 3700 tracks.Maximum reference time duration is met by the treatment time that timer 3700 tracks,
Processor 1006 indicates that effector 1008 stops activation.In one embodiment, processor 1006 is configured to respond to effect
The treatment intensity of device 1008 and the activation for stopping effector 1008.For example, the accessible treatment referenced strength (example of processor 1006
Such as, store, or can be accessed by processor 1006 in memory 1302) maximum intensity, thus processor 1006 can
With the treatment intensity that the operation (for example, during single treatment, during multiple treatments etc.) compared by effector 1008 provides,
It can depend on the power output of effector 1008, the duration for the treatment of of effector 1008, effector 1008 treatment frequency
Rate etc..When the treatment intensity determined by processor 1006 meets the maximum intensity for the treatment of referenced strength, processor 1006 is indicated
Effector 1008 stops activation.
In one embodiment, effector 1008 is configured to influence physical feeling with treatment of arthritis (for example, Bones and joints
Inflammation, rheumatoid arthritis, psoriatic arthritis etc.), arthralgia, myalgia, neuralgia, enthesitis, myalgia, fibromyalgia,
At least one of headache or treatment of traumatic pain.In one embodiment, effector 1008 is configured as through active treatment shadow
Ring physical feeling.For example, processor 1006 can indicate that effector 1008 influences when individual subjects just undergo pain status
Physical feeling.In one embodiment, effector 1008 is configured as influencing physical feeling by prophylactic treatment.For example, working as
When the pain status of individual subjects is less than threshold value pain, processor 1006 can indicate that effector 1008 is undergone in individual subjects
Physical feeling is influenced before pain status or induction individual subjects are mobile to prevent pain status.In one embodiment, it imitates
Device 1008 is answered to be configured as influencing physical feeling by palliative treatment.
In one embodiment, system 1000 is configured to determine that or is received to the individual subjects where system 1000
Mark, to determine whether to provide or enable certain functions.For example, system 1000 can be configured as only for certain authorization individuals
Operation disables certain feature or functions thus if unidentified or unauthorized people attempts to use system 1000.It is real one
It applies in scheme, system 1000 is configured as the individual subjects where identifying system 1000, and thus system 1000 makes certainly
Certain system units can be operated when identifying the individual for being authorized to use particular system 1000.For example, sensor module 1004 can
With the physical trait of the individual subjects where detection system 1000, to generate one or more bodies associated with physical trait
Part sensing signal.Physical trait may include but be not limited to skin shape characteristic (for example, skin surface pattern, hair follicle pattern, hole
Pattern, pigmentation etc.), vessel properties or layout (for example, artery pattern, characteristic or layout;Vein pattern, characteristic or layout
Deng), current-mode (for example, photovoltaic current-mode) or dermal resistance rate measurement.In one embodiment, processor 1006 or its
Identity sensing signal is compared system unit by he with the reference data for the individual for being associated with the system of being authorized to use 1000.When
When identity sensing signal and reference data have the corresponding relationship of affirmative, system 1000 can make it possible to operate certain system function
Can, include but is not limited to make it possible to operate sensor module 1004 to carry out pain monitoring, makes it possible to 1008 (example of operational effect device
Such as, only in the association of individual certainly, when so that individual being authorized to operating system 1000), select particular treatment (for example, ginseng
Examining data may include the corresponding relationship between identity and particular treatment, thus after confirming identity, select particular treatment
Scheme is with the operation for effector 1008) so that information relevant to the state of the operation of system 1000 or individual subjects
(for example, electric health record or other healthy diaries) etc. can be transferred at record.
The state of the art has developed to such a degree: the hardware of many aspects of system, software and/or solid
Almost without difference between part implementation;The use of hardware, software and/or firmware is usually (but not always, because certain
In situation, the selection between hardware and software can become significant) representative cost and benefit tradeoff design alternative.There are energy
Enough realize the variety carrier of approach described herein and/or system and/or other technologies (for example, hardware, software and/or solid
Part), and preferred carrier can become according to the situation of deployment the method and/or system and/or other technologies.For example, if
Implementer determine speed and accuracy be it is most important, then the carrier of predominantly hardware and/or firmware may be selected in implementer;Substitution
Ground, if flexibility is most important, the implementation of the optional predominantly software of implementer;Alternatively, implement again alternatively
Some combinations of hardware, software and/or firmware may be selected in person.Accordingly, there exist can be realized approach described herein and/or set
Standby and/or other technologies several viable carriers are inherently better than other carriers without a kind of carrier, because will be made
Any carrier be according to dispose the carrier situation and implementer focus particularly on point (for example, speed, flexibility or
Predictability) depending on selection, and any of them one may all change.It will be appreciated by those skilled in the art that realizing
The optics aspect of mode can generally use the hardware, software and/or firmware of optics aspect.
In some implementations described herein, logic and similar implementation may include software or other controls
Structure.For example, electronic circuit can have one or more electric currents being constructed and arranged to realize various functions described herein
Path.In some implementations, one or more media can be configured to keep or transmit in this medium to run by this
Load bearing equipment detectable implementation when the equipment of the text execution can detect instruction.In some change case, for example, realizing
Mode may include update to existing software or firmware or gate array or programmable hardware or other modifications, for example, by execute with
It is described herein one or more operate it is relevant one or more instruction receive or send realization.Alternately or in addition, exist
In some change case, implementation may include dedicated hardware, software, fastener components and/or execution or otherwise call
The general purpose module of personal module.Specification or other implementations can pass through one or more of tangible transmission media described herein
Example is sent, optionally by grouping transmission or otherwise by passing through distributed medium in different times.
Alternatively or additionally, implementation may include executing special instruction sequence or otherwise calling for making
It can, trigger, coordinate, request or be otherwise result in the circuit of above-mentioned any feature operation occurred one or more times.Some
In change case, the operability of this paper or the description of other logicalities can be directly expressed as source code and be compiled as or with its other party
It is executable instruction sequence that formula, which is called,.In some situations, for example, C++ or other code sequences can be by direct compilations or with it
His mode be embodied as senior descriptor language (for example, can logic synthetic language, hardware description language, hardware design emulation and/or
Other such expression patterns).Alternately or in addition, some or all of logical expression with hardware physics realization it
Before can be expressed as Verilog type hardware description or other circuit models, answered in particular for basic operation or sequential key type
With.In view of these introductions, those skilled in the art will understand how to obtain, configuration and the suitable transmission of optimization or computing element,
Material supply, actuator or other universal architectures.
The detailed description of front elaborates system, equipment by the use of block diagram, flow chart and/or embodiment
And/or the various embodiments of method.As long as these block diagrams, flow chart and/or embodiment include one or more functions and/
Or operation, it will be appreciated by those skilled in the art that each function in such block diagram, flow chart or embodiment and/or
Operation can be realized by oneself and/or jointly by hardware in extensive range, software, firmware or their almost any combination.
In embodiments, if the stem portion of subject matter described herein can pass through specific integrated circuit (ASIC), field programmable gate
Array (FPGA), digital signal processor (DSP) or other integrated forms are realized.However, embodiments disclosed herein
Some aspects can wholly or partly equivalence enforcement in integrated circuits, as one run on one or more computers or
Multiple computer programs (for example, as one or more programs run in one or more computer systems), as one or
One or more programs run on multiple processors are (for example, as one or more journeys run on one or more microprocessors
Sequence), as firmware or as their almost any combination, and in view of the disclosure, design circuit and/or write for software
And/or the code of firmware can be completely in the limit of power of those skilled in the art.In addition, the mechanism of subject matter described herein
Various forms of program products can be distributed as, and is applicable in the illustrated embodiment of subject matter described herein and is used for
The specific type of the practical signal bearing medium for executing distribution is unrelated.
In a general sense, it will be understood by those skilled in the art that embodiments described herein can be by having
It electric component (such as hardware, software, firmware and/or their almost any combination) in extensive range and in extensive range assigns
Give mechanical force or movement component (such as rigid body, spring or twist mechanism, hydraulic system, electromagnetic actuating device and/or they
Almost any combination) various types of Mechatronic Systems individually and/or jointly realize.Therefore, " machine used herein
Electric system " includes but is not limited to: grasping with converter (for example, actuator, motor, piezo-electric crystal, MEMS (MEMS) etc.)
The circuit that operatively couples, the circuit at least one integrated circuit, has extremely the circuit at least one discrete circuit
The circuit of a few specific integrated circuit forms the universal computing device configured by computer program (for example, by least partly
Realize the general purpose computer of the computer program configuration of approach described herein and/or equipment or by least partly realizing
The computer program of approach described herein and/or equipment configuration microprocessor) circuit, formed storage equipment (for example,
Various forms of memories (for example, random access memory, flash memory, read-only memory etc.)) circuit, formed communication equipment
The circuit of (for example, modem, communication switchboard, optoelectronic device etc.), and/or non-electric system similar therewith are (for example, light
Similar systems learn or other).It should be appreciated by those skilled in the art that the example of Mechatronic Systems includes but is not limited to various disappears
Expense property electronic product system, Medical Devices and other systems, such as electric transportation system, factory automation system, safety system
System and/or communication/computing system.One skilled in the art would recognize that unless the context requires otherwise, otherwise being made herein
Electromechanics is not necessarily limited to electrically and mechanically activate system both with the two.
In a general sense, described herein to pass through hardware in extensive range, software, firmware and/or their times
The various aspects that meaning combination is realized by oneself and/or jointly can be considered as including various types of " circuits ".Therefore, this paper institute
" circuit " used includes but is not limited to: the circuit at least one discrete circuit, the electricity at least one integrated circuit
Road, the circuit at least one specific integrated circuit, formed configured by computer program universal computing device (for example, by
At least partly realize the general purpose computer of the computer program configuration of approach described herein and/or equipment or by least
Partly realize the microprocessor of the computer program configuration of approach described herein and/or equipment) circuit, form storage
The circuit of equipment (for example, various forms of memories (for example, random access memory, flash memory, read-only memory etc.)) and/
Or form the circuit of communication equipment (for example, modem, communication switchboard, optoelectronic device etc.).Subject matter described herein
It can be in a manner of analog or digital or their some combinations are realized.
Those skilled in the art will appreciate that at least part of system as described herein and/or technique can be integrated
Into image processing system.Typical image processing system generally comprises one or more in lower list: system unit housing, view
Frequency display equipment, the memory of such as volatibility or nonvolatile memory etc, such as microprocessor or Digital Signal Processing
The computational entity of the processor of device etc, such as operating system etc, driver, application program, one or more interactive device (examples
Such as, touch tablet, touch screen, antenna etc.) including feedback loop and control motor (for example, for sensing lens location and/or speed
The feedback of degree, the control motor that desired focus is provided for moving/distorting camera lens) control system.Image processing system
Using the suitable of such as those commercially available components usually found in Digital Still system and/or digital mobile system etc
Commercially available component realize.
Those skilled in the art will appreciate that at least part of system as described herein and/or technique can be integrated
Into data processing system.Data processing system generally comprises one or more in lower list: system unit housing, video are shown
The memory of equipment, such as volatibility or nonvolatile memory etc, such as microprocessor or digital signal processor etc
Processor, the computational entity of such as operating system etc, driver, graphic user interface, application program, one or more interactions
Equipment (for example, touch tablet, touch screen, antenna etc.), and/or including feedback loop and control motor (for example, be used for sensing the feedback of position
And/or the feedback of speed, the control motor for moving and/or adjusting component and/or quantity) control system.Data processing
System is using such as those suitable cities usually found in data calculating communication and/or network calculations communication system
Component is sold to realize.
It will be appreciated by those skilled in the art that at least part of system as described herein and/or technique can be integrated
Into micronic dust (mote) system.It will be appreciated by those skilled in the art that typical mote system generally comprises one in lower list
Or it is multinomial: the memory of such as volatibility or nonvolatile memory etc, such as microprocessor or digital signal processor it
The computational entity of the processor of class, such as operating system etc, user interface, driver, sensor, actuator, application program,
One or more interactive devices (for example, antenna USB port, audio port etc.) including feedback loop and control motor (for example, with
In sensing or estimated location and/or the feedback of speed, the control motor for moving and/or adjusting component and/or quantity) control
System processed.Mote system can be realized using such as those suitable components found in mote calculating/communication system.This
The specific example of kind of component include such as intel corporation (Intel Corporation) and/or Ke Ersibo company
The mote component of (Crossbow Corporation) and hardware, software and/or the firmware of support.
In some cases, the use of system or method can occur in somewhere, except component is located at this area
So.For example, in a distributed computing environment, the use of distributed computing system can occur in somewhere, but the portion of the system
Part but can be located at this area except (for example, be located at this area except relay, server, processor, signal bearing medium,
Send computer, receive computer etc.).Equally, the sale of system or method can occur in somewhere, but the group of system or method
Part is but located at except this area and/or is used except this area.
In addition, at least part of realization of the system for executing method in an area does not interfere the system another
Use in one area.
(for example, operation), equipment, object and adjoint it will be appreciated by those skilled in the art that components described herein
Their discussion is for the purpose of clear concept is used as example, and various configuration modifications are predictable.Therefore, as herein
Used, the specific example and subsidiary discussion illustrated is intended to represent its more generally class.In general, any specific
It is exemplary using being intended to represent its class, and specific component (for example, operation), equipment and object do not include being not construed as
Limitation.
For the substantially any plural number of this paper and/or the use of singular references, those skilled in the art can be according to upper and lower
Complex conversion is odd number and/or odd number is converted to plural number by text and/or application.For clarity, various singular/plural displacements
It does not illustrate specially herein.
Subject matter described herein elaborate sometimes include it is in different other components or from other different portions
The different components that part is connected.It should be appreciated that the framework described in this way is only exemplary, and in fact implementable realization
Many other frameworks of identical function.In conceptual meaning, realize that any part setting of identical function all effectively " is closed
Connection ", the function of making it desirable to is achieved.Therefore, it combines herein to realize that any two component of specific function can quilt
Be considered as " operatively coupled " each other so that desired function is achieved, regardless of framework or intermediate member how.Equally, this
The associated any two component of sample can also be considered as " being operatively connected " each other or " operatively coupled " is desired to realize
Function, and can any two component associated in this way can also be considered as desired to realize each other " can be operatively coupled "
Function.Specific example that can be operatively coupled include but is not limited to be capable of physics pairing and/or physics interaction component,
And/or be capable of wireless interaction and/or wireless interaction component, and/or logic interaction and/or be capable of logic interaction portion
Part.
In some cases, one or more components are referred to alternatively as " being configured to " herein, " being configured to ", " can grasp
Work/operation comes ", " suitable for/may be adapted to ", " can ", " can in accordance with/in accordance with " etc..It will be appreciated by those skilled in the art that on unless
It hereafter requires otherwise, otherwise such term (for example, " being configured to ") can generally comprise the component of active state and/or non-live
The component of dynamic state and/or the component of armed state.
Though the particular aspects of theme as described herein have been illustrated and described, it will be clear that those skilled in the art,
Based on teaching herein, it can make a change and repair without departing substantially from subject matter described herein and its wider range of aspect
Change, therefore, all such changes and modification are included in their scope by the attached claims, are considered as and are retouched in this paper
In the true spirit and range of the theme stated.
It will be appreciated by those skilled in the art that in general, herein especially in appended claims (for example, appended power
Benefit require main body) used in term be generally intended to as " open " term (for example, term "comprising" should be explained
For " including but not limited to ", term " having " should be interpreted " having at least ", term " includes " should be interpreted " including
But it is not limited to ", etc.).Those skilled in the art are it will be further understood that if be intended to institute's introducing claim statement object
Particular number, then this intention can be explicitly recited in the claim, and if there is no such record, just it is not present
Such intention.For example, as the auxiliary to understanding, claims appended below may include introducing phrase "at least one" and
The use of " one or more " states object with introducing claim.But the use of this kind of phrase should not be construed as to imply that
It will be stated containing this institute's introducing claim by the introducing that indefinite article "a" or "an" states object to claim
Any specific rights requirement of object is limited to the claim only comprising a this statement object, even if wanting in same right
When asking including the indefinite articles such as introducing phrase " one or more " or "at least one" and "a" or "an" also so (example
Such as, " one " and/or "one" should be typically interpreted to refer to "at least one" or " one or more ");For being weighed for introducing
It is also same for the use of the definite article of benefit requirement statement object.In addition, even if institute's introducing claim has been expressly recited
State the particular number of object, skilled persons will also appreciate that, this record should generally also be interpreted to refer to
It is that documented quantity (for example, only recording " two statement objects " without other modifiers, typically refers at least two less
State object or two or more statement object).In addition, using similar with " at least one of A, B and C etc. " usual
In the case of language, it is however generally that, this structure mean it will be understood by those skilled in the art that usual meaning (for example, " having
A, the system of at least one of B and C " will include but be not limited to the only system of the A, system of only B, the system of only C, same
When system with A and B, there is the system of A and C while there is the system of B and C, and/or there is A, B and C simultaneously simultaneously
System, etc.).In the case of using the idiom similar with " at least one of A, B or C etc. ", it is however generally that, this
Kind of structure mean it will be understood by those skilled in the art that usual meaning (for example, " system at least one of A, B or C "
It will include but be not limited to the only system of A, the system of only B, the system of only C while there is the system of A and B while having
The system of A and C has the system of B and C, and/or the system simultaneously with A, B and C, etc. simultaneously).Those skilled in the art
It will be further understood that in general, unless context clearly states, otherwise propose disjunction word that two or more may be selected items and/or
Phrase, either in specification, claims, still in the accompanying drawings, all should be understood as it is estimated including one of them, appoint
One or two a possibility that.For example, phrase " A or B " would generally be understood to include the possibility of " A " or " B " or " A and B "
Property.
The disclosure is carried out referring to various exemplary implementation schemes.However, those skilled in the art will appreciate that not
Embodiment can be changed and modified in the case where being detached from disclosure range.For example, according to concrete application or considering and being
The associated any amount of cost function of the operation of system, various operating procedures and component for carrying out operating procedure can be with
Implemented with alternative;For example, one or more steps can be deleted, modifies or be combined with other steps.
In addition, as one of ordinary skill will recognize, the principle of the disclosure including component can reflect
In computer program product on computer readable storage medium, the computer readable storage medium, which has, is embodied in storage
Computer readable program code component in medium.Using any tangible, non-transitory computer-readable storage media, packet
Include magnetic storage apparatus (hard disk, floppy disk etc.), light storage device (CD-ROM, DVD, Blu-ray Disc etc.), flash memory and/or analog.
These computer program instructions can be loaded into general purpose computer, special purpose computer or other programmable data processing devices to produce
Life device, so that the instruction executed on computer or other programmable data processing units creates for realizing specified function
Component.These computer program instructions can also be stored in computer readable memory, and the computer-readable memory can
Guidance computer or other programmable data processing units are run in a specific way, so that being stored in computer-readable memory
Instruction generate product, the execution component including executing specified function.Computer program instructions can also be loaded into computer or its
So that series of operation steps are executed on a computer or other programmable device to produce in its programmable data processing unit
The process that raw computer executes, so that the instruction executed on a computer or other programmable device is provided for realizing specified function
The step of energy.
Previous embodiment is described by reference to various embodiments.However, those of ordinary skill in the art will
It recognizes, can carry out various modifications and change without departing from the scope of this disclosure.Accordingly, it is to be understood that the disclosure is to say
Bright property rather than it is restrictive, and it is all it is such modification be intended to include within its scope.Equally, above about various realities
The scheme of applying describes beneficial effect, further advantage and solution to the problem.However, can lead to any beneficial effect, advantage or
Beneficial effect, advantage, solution to the problem and any element that solution occurs or becomes more apparent upon should not be managed
It solves to be crucial, required or basic feature or element.As used herein, the terms "include", "comprise" and its it is any its
What its modification was intended to cover nonexcludability includes, so that the process, method, product or the equipment that include element list not only include that
A little elements, and may include be not explicitly listed or such process, method, system, product or device intrinsic other members
Element.
In one embodiment, system integrates in this way, i.e., system is set as special configuration for pain therapy
The unique system of the function of standby or system (for example, system 100), and any related computing devices of system are as claimed
System special purpose computer rather than general purpose computer.In one embodiment, at least one of system is associated
Special purpose computer of the calculating equipment for system claimed, rather than general purpose computer.In one embodiment,
The associated calculating equipment of at least one of system and specific ROM hardwired are to indicate that at least one calculates equipment.Implement one
In scheme, those skilled in the art are recognized, pain therapy equipment or system (for example, system 100) at least in pain sensing and
Improvement is realized in the technical field of pain therapy.
Although disclosed herein many aspects and embodiment, to those skilled in the art, other aspects and
Embodiment can be obvious.Various aspects disclosed herein and embodiment be for purposes of illustration and be not intended into
Row limitation, real scope and spirit are shown by next claim.
Claims (49)
1. a kind of system comprising:
Deformable substrate is configured to engage with the skin surface of the physical feeling of individual subjects;
Sensor module, is coupled to the deformable substrate, and the sensor module includes motion sensor and physiology sensing
Device, the sensor module be configured as based on by the motion sensor to the detection of the movements of parts of the body and by institute
Biosensor is stated to the detection of the physiological parameter of the physical feeling to generate one or more sensing signals;
Processor can be operatively coupled to the sensor module and be configured as receiving one or more of sensing letters
Number, the processor includes being configured as at least one of the movement or the physiological parameter based on the physical feeling
Come identify the individual subjects physiological status circuit;With
Effector can be operatively coupled to the processor and be configured to respond to the control of the processor and influence
The physical feeling.
2. system according to claim 1, wherein the effector includes at least one ultrasonic transducer.
3. system according to claim 1, wherein at least one described ultrasonic transducer is configured as according at least first
Treatment mode and the second treatment mode generate ultrasonic signal.
4. system according to claim 1, wherein the processor is configured to guiding at least one described ultrasonic transduction
Device is alternately produced the ultrasonic signal according to first treatment mode and second treatment mode on a dynamic basis.
5. system according to claim 4, wherein first treatment mode is according to the bodies of the individual subjects
At least one of the target site of body region or the target depth of the physical feeling of the individual subjects and described
Two treatment modes are different.
6. system according to claim 1, wherein at least one described ultrasonic transducer is configured as according to multiple ultrasounds
Frequency generates ultrasonic signal.
7. system according to claim 1, wherein at least one described ultrasonic transducer includes: the first ultrasonic transducer,
It is configured as on the first position being placed in the physical feeling of the individual subjects;With the second ultrasonic transducer,
It is configured as on the second position being placed in the physical feeling of the individual subjects.
8. system according to claim 1, wherein the effector includes electrode, magnetic stimulator, photic stimulator, thermostimulation
At least one of device, the acoustic stimulator, mechanical stimulator or vibratory stimulation device.
9. system according to claim 1, wherein the biosensor includes electro-physiological sensor, electrocardiography
At least one of device, electroculogram tracer, micro- neural tracer, myograph or electromyograph.
10. system according to claim 1, wherein the biosensor includes strain transducer, temperature sensor, light
Learn sensor or pressure sensor.
11. system according to claim 10, wherein at least one of the biosensor or the processor wrap
Include the circuit for being configured to determine that the risk for the chronic stress being applied in the physical feeling.
12. system according to claim 10, wherein the biosensor includes near infrared sensor, skin conductivity biography
In sensor, bio-impedance sensor, pH sensor, chemical sensor, motion sensor, aspect sensor or acoustic sensor
At least one.
13. system according to claim 12, wherein the chemical sensor includes biomarker specific sensor
Component.
14. system according to claim 12, wherein the chemical sensor is configured to the analyte in detection sweat.
15. system according to claim 12, wherein the aspect sensor includes single-axis accelerometer, pairs of phase
To the single-axis accelerometer of alignment, it is configured to antenna, range sensor, multi-axial accelerometer, gyroscope or the survey of measurement field source
At least one of oblique instrument.
16. system according to claim 12, wherein the motion sensor include accelerometer, pressure sensor or
Proximity sensor.
17. system according to claim 16, wherein the proximity sensor is configured as sensing close to the body
Second physical feeling of position.
18. system according to claim 12, wherein the motion sensor is configured as measuring the physical feeling
Duplicate movement.
19. system according to claim 12, wherein the motion sensor is configured as measuring the physical feeling
The number of repetition of movement.
20. system according to claim 12, wherein the motion sensor is configured as measuring the physical feeling
At least one in the angle of the speed of movement, the duration of the movements of parts of the body or the movements of parts of the body
Person.
21. system according to claim 12, wherein the motion sensor is configured as to the processor transmission table
Show one or more signals of the motion state of the individual subjects.
22. system according to claim 12, wherein the motion sensor is configured as to the processor transmission table
Show one or more signals of the resting state of the individual subjects.
23. system according to claim 1, wherein the processor is configured to only the physical feeling during the break
The effector is activated to influence the physical feeling.
24. system according to claim 1 further includes user interface.
25. system according to claim 1, wherein the processor can be operatively coupled to the user interface, and
One or more signals of communication are configurable to generate so that the user interface is shown.
26. system according to claim 25, wherein one or more of signals of communication include user input about
The request of the mode of operation of the effector.
27. system according to claim 1, wherein the processor is configured in response to via the user interface
User command and the activation for preventing the effector.
28. system according to claim 1, wherein the processor is configured in response to via the user interface
User command activates the effector.
29. system according to claim 1 further includes the timer that can be operatively coupled to the effector.
30. system according to claim 1, wherein the effector is configured to influence the physical feeling, to be used for
Treatment of arthritis, arthralgia, neuritis, neuralgia, enthesitis, start-stop point pain, myositis, myalgia, fibromyalgia, headache or wound
At least one of wound property pain.
31. system according to claim 1, wherein the physical feeling is joint, connective tissue, nerve fiber or muscle
At least one of.
32. system according to claim 1, wherein the physical feeling include finger, hand, wrist, toe, foot, ankle,
In arm, ancon, leg, knee, shoulder, ear, neck, head, buttocks, backbone position, articulatio sacroiliaca or trunk at least
One.
33. system according to claim 1, wherein the deformable substrate include elastomer polymer, hydrocolloid film,
One of film, nanometer film or breathable elastomeric piece are a variety of.
34. system according to claim 1, wherein the deformable substrate includes glove part, fingerstall part, parcel
Point, at least one of joint support part or garment parts.
35. system according to claim 1, further include: it is configured as receiving the one or more from external equipment
At least one of receiver or transceiver of signal of communication.
36. system according to claim 35, wherein the external equipment includes the biography in the individual subjects
Sensor.
37. system according to claim 35, wherein the processor is configured in response to coming from the external equipment
One or more of signals of communication and activate the effector to influence the physical feeling.
38. system according to claim 35, wherein the processor is configured in response to coming from the external equipment
One or more of signals of communication and prevent the activation of the effector.
39. system according to claim 35, wherein the external equipment includes the sensing far from the individual subjects
Device.
40. system according to claim 1 further includes neural sensor, the neural sensor is configured as identifying
The neural target acted for the effector.
41. a kind of method comprising:
Via the physiological parameter of epidermis electronic system (EES) detection movements of parts of the body and the physical feeling;
The detection of the physiological parameter based on the movement and the physical feeling to the physical feeling, generate one or
Multiple sensing signals;
One or more of sensing signals are received with computer processor;
The individual subjects are identified based at least one of the movement of the physical feeling or described physiological parameter
Physiological status;And
When identifying the physiological status, control signal is sent with activation effect device and acts on the physical feeling.
42. according to the method for claim 41, wherein the movement or the physiological parameter based on the physical feeling
At least one of include: the physiological status that identifies the individual subjects
The pain of the individual is identified based at least one of the movement of the physical feeling or described physiological parameter
At least one of state, pain level, types of pain or pain quality.
43. according to the method for claim 41, wherein based in the movements of parts of the body or the physiological parameter
At least one sends control signal with activation effect device and acts on the physical feeling when identifying the physiological status
Include:
When identifying the physiological status of the individual subjects, control signal is sent to activate at least one ultrasonic transduction
Device acts on the physical feeling.
44. according to the method for claim 43, wherein in at least one pain for identifying the individual subjects
When state, sends control signal and act on the physical feeling to activate at least one ultrasonic transducer and include:
In at least one pain status for identifying the individual subjects, control signal is sent to activate array ultrasonic
Energy converter acts on the physical feeling.
45. according to the method for claim 41, further include:
The ultrasound letter is alternately produced between first treatment mode and second treatment mode on a dynamic basis
Number.
46. according to the method for claim 41, further include: measure the physical feeling repeating motion or the body
At least one of the number of repetition of movement at position.
47. according to the method for claim 41, further include:
Measure the speed of the movement of the physical feeling, the duration of the movement of the physical feeling, the body
When body region is located at the threshold distance of the second physical feeling of distance relative to arrangement, the physical feeling of the second physical feeling
In the angle of the quantity of interior situation, the movements of parts of the body, or power relevant to the movements of parts of the body extremely
Few one.
48. according to the method for claim 41, wherein detect movements of parts of the body via epidermis electronic system (EES)
Physiological parameter with the physical feeling includes:
By the resting state for indicating the motion states of the individual subjects, the individual subjects or the individual subjects
One or more signals of at least one of the duration of resting state are sent to the computer processor.
49. according to the method for claim 41, further include:
It duration in response to the treatment carried out by the effector, the intensity of the treatment carried out by the effector or comes from
At least one of one or more signals of communication of external equipment stop activating the effector.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/361,953 US10279200B2 (en) | 2014-07-17 | 2016-11-28 | Monitoring and treating pain with epidermal electronics |
US15/361,999 | 2016-11-28 | ||
US15/361,953 | 2016-11-28 | ||
US15/361,999 US10279201B2 (en) | 2014-07-17 | 2016-11-28 | Monitoring and treating pain with epidermal electronics |
PCT/US2017/063243 WO2018098417A1 (en) | 2016-11-28 | 2017-11-27 | Monitoring and treating pain with epidermal electronics |
Publications (1)
Publication Number | Publication Date |
---|---|
CN110290834A true CN110290834A (en) | 2019-09-27 |
Family
ID=62195587
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201780084773.4A Pending CN110290834A (en) | 2016-11-28 | 2017-11-27 | With epidermis electronic monitoring and treatment pain |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP3544681A4 (en) |
JP (1) | JP2020512846A (en) |
CN (1) | CN110290834A (en) |
TW (1) | TW201825045A (en) |
WO (1) | WO2018098417A1 (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110840412A (en) * | 2019-12-09 | 2020-02-28 | 苏州大学 | Pain signal detection device based on animal body communication and detection method thereof |
CN111319320A (en) * | 2020-02-27 | 2020-06-23 | 电子科技大学 | Multifunctional electronic fabric and construction method and application thereof |
CN111568382A (en) * | 2020-05-21 | 2020-08-25 | 中国计量科学研究院 | Intelligent measurement system for intra-thyroid irradiation iodine measurement |
CN111714354A (en) * | 2020-06-09 | 2020-09-29 | 北京航空航天大学 | Intelligent ultrasonic pain relieving device |
CN112023265A (en) * | 2020-09-28 | 2020-12-04 | 杭州神络医疗科技有限公司 | Electrical stimulation device |
CN112617749A (en) * | 2019-11-19 | 2021-04-09 | 奇异平台股份有限公司 | Physiological and biochemical monitoring device |
CN113243892A (en) * | 2021-06-28 | 2021-08-13 | 遵义医科大学附属医院 | Multifunctional pain assessment mold |
CN113288419A (en) * | 2021-05-28 | 2021-08-24 | 常州纵慧芯光半导体科技有限公司 | Laser device and appearance that moults |
CN116649972A (en) * | 2023-07-04 | 2023-08-29 | 珠海美华医疗科技有限公司 | Blood collection auxiliary device for blood culture bottle |
TWI817409B (en) * | 2021-04-22 | 2023-10-01 | 群創光電股份有限公司 | Electronic device and operation method thereof |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11247039B2 (en) | 2016-05-03 | 2022-02-15 | Btl Healthcare Technologies A.S. | Device including RF source of energy and vacuum system |
US10583287B2 (en) | 2016-05-23 | 2020-03-10 | Btl Medical Technologies S.R.O. | Systems and methods for tissue treatment |
US10556122B1 (en) | 2016-07-01 | 2020-02-11 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
LU100021B1 (en) * | 2017-01-13 | 2018-07-30 | Adapttech Ltd | Socket fitting system |
TWI676788B (en) * | 2018-10-12 | 2019-11-11 | 研能科技股份有限公司 | Health monitoring device |
TWI699783B (en) * | 2018-11-08 | 2020-07-21 | 佛教慈濟醫療財團法人 | Intelligent medical treatment auxiliary system and method thereof |
US11642081B2 (en) | 2019-02-01 | 2023-05-09 | X Development Llc | Electrode headset |
US11583231B2 (en) | 2019-03-06 | 2023-02-21 | X Development Llc | Adjustable electrode headset |
WO2020209846A1 (en) * | 2019-04-09 | 2020-10-15 | Somniferum Labs LLC | Pain level determination method, apparatus, and system |
CN117771550A (en) * | 2019-04-11 | 2024-03-29 | 比特乐医疗方案股份有限公司 | Device for providing a time-varying magnetic field and a radio frequency field to a body region of a patient |
TR201917004A2 (en) | 2019-11-04 | 2021-05-21 | Zorluteks Tekstil Ticaret Ve Sanayi Anonim Sirketi | AN ELECTRIC STIMULATING SYSTEM |
JP2021129891A (en) * | 2020-02-21 | 2021-09-09 | 住友電気工業株式会社 | Terminal device, emotion analysis device, emotion analysis system, and emotion analysis method |
KR102355171B1 (en) * | 2020-03-02 | 2022-01-26 | 고려대학교 산학협력단 | High Voltage Microcurrent Diagnostic Device |
TWI799740B (en) * | 2020-03-05 | 2023-04-21 | 緯創資通股份有限公司 | Optical sensing device |
TWI773972B (en) * | 2020-03-05 | 2022-08-11 | 緯創資通股份有限公司 | Optical sensing device |
AU2021269187B2 (en) | 2020-05-04 | 2023-02-23 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
US11878167B2 (en) | 2020-05-04 | 2024-01-23 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
CN114077301B (en) * | 2020-08-20 | 2023-10-10 | 鹏鼎控股(深圳)股份有限公司 | Virtual reality glove and manufacturing method thereof |
CN117897208A (en) * | 2021-07-12 | 2024-04-16 | 科尔泰利公司 | Wearable device for generating external shock waves |
US11896816B2 (en) | 2021-11-03 | 2024-02-13 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090076343A1 (en) * | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Energy Management for Adherent Patient Monitor |
US20160015280A1 (en) * | 2014-07-17 | 2016-01-21 | Elwha Llc | Epidermal electronics to monitor repetitive stress injuries and arthritis |
WO2016019250A1 (en) * | 2014-08-01 | 2016-02-04 | Tricord Holdings, Llc | Modular physiologic monitoring systems, kits, and methods |
US20160129274A1 (en) * | 2014-11-10 | 2016-05-12 | Sam Boong Park | Wearable energy delivery system |
US20160228640A1 (en) * | 2015-02-05 | 2016-08-11 | Mc10, Inc. | Method and system for interacting with an environment |
US20160242646A1 (en) * | 2015-07-07 | 2016-08-25 | Padraic R. Obma | Noninvasive medical monitoring device, system and method |
US20160317383A1 (en) * | 2013-12-31 | 2016-11-03 | Iftech Inventing Future Technology Inc. | Wearable devices, systems, methods and architectures for sensory stimulation and manipulation and physiological data acquisition |
-
2017
- 2017-11-22 TW TW106140457A patent/TW201825045A/en unknown
- 2017-11-27 JP JP2019528460A patent/JP2020512846A/en active Pending
- 2017-11-27 EP EP17875036.0A patent/EP3544681A4/en not_active Withdrawn
- 2017-11-27 WO PCT/US2017/063243 patent/WO2018098417A1/en active Application Filing
- 2017-11-27 CN CN201780084773.4A patent/CN110290834A/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090076343A1 (en) * | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Energy Management for Adherent Patient Monitor |
US20160317383A1 (en) * | 2013-12-31 | 2016-11-03 | Iftech Inventing Future Technology Inc. | Wearable devices, systems, methods and architectures for sensory stimulation and manipulation and physiological data acquisition |
US20160015280A1 (en) * | 2014-07-17 | 2016-01-21 | Elwha Llc | Epidermal electronics to monitor repetitive stress injuries and arthritis |
WO2016019250A1 (en) * | 2014-08-01 | 2016-02-04 | Tricord Holdings, Llc | Modular physiologic monitoring systems, kits, and methods |
US20160129274A1 (en) * | 2014-11-10 | 2016-05-12 | Sam Boong Park | Wearable energy delivery system |
US20160228640A1 (en) * | 2015-02-05 | 2016-08-11 | Mc10, Inc. | Method and system for interacting with an environment |
US20160242646A1 (en) * | 2015-07-07 | 2016-08-25 | Padraic R. Obma | Noninvasive medical monitoring device, system and method |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112617749A (en) * | 2019-11-19 | 2021-04-09 | 奇异平台股份有限公司 | Physiological and biochemical monitoring device |
CN110840412A (en) * | 2019-12-09 | 2020-02-28 | 苏州大学 | Pain signal detection device based on animal body communication and detection method thereof |
CN111319320A (en) * | 2020-02-27 | 2020-06-23 | 电子科技大学 | Multifunctional electronic fabric and construction method and application thereof |
CN111568382A (en) * | 2020-05-21 | 2020-08-25 | 中国计量科学研究院 | Intelligent measurement system for intra-thyroid irradiation iodine measurement |
CN111568382B (en) * | 2020-05-21 | 2023-04-07 | 中国计量科学研究院 | Intelligent measurement system for intra-thyroid irradiation iodine measurement |
CN111714354A (en) * | 2020-06-09 | 2020-09-29 | 北京航空航天大学 | Intelligent ultrasonic pain relieving device |
CN111714354B (en) * | 2020-06-09 | 2021-11-26 | 北京航空航天大学 | Intelligent ultrasonic pain relieving device |
CN112023265A (en) * | 2020-09-28 | 2020-12-04 | 杭州神络医疗科技有限公司 | Electrical stimulation device |
TWI817409B (en) * | 2021-04-22 | 2023-10-01 | 群創光電股份有限公司 | Electronic device and operation method thereof |
CN113288419A (en) * | 2021-05-28 | 2021-08-24 | 常州纵慧芯光半导体科技有限公司 | Laser device and appearance that moults |
CN113243892A (en) * | 2021-06-28 | 2021-08-13 | 遵义医科大学附属医院 | Multifunctional pain assessment mold |
CN116649972A (en) * | 2023-07-04 | 2023-08-29 | 珠海美华医疗科技有限公司 | Blood collection auxiliary device for blood culture bottle |
CN116649972B (en) * | 2023-07-04 | 2024-03-29 | 珠海美华医疗科技有限公司 | Blood collection auxiliary device for blood culture bottle |
Also Published As
Publication number | Publication date |
---|---|
EP3544681A4 (en) | 2020-06-10 |
JP2020512846A (en) | 2020-04-30 |
WO2018098417A1 (en) | 2018-05-31 |
EP3544681A1 (en) | 2019-10-02 |
TW201825045A (en) | 2018-07-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN110290834A (en) | With epidermis electronic monitoring and treatment pain | |
CN110248601A (en) | Body kinematics or situation are monitored according to motion scheme using conformal electronic device | |
US10390755B2 (en) | Monitoring body movement or condition according to motion regimen with conformal electronics | |
US10383550B2 (en) | Monitoring body movement or condition according to motion regimen with conformal electronics | |
US10279200B2 (en) | Monitoring and treating pain with epidermal electronics | |
US10279201B2 (en) | Monitoring and treating pain with epidermal electronics | |
JP7296344B2 (en) | Conformal sensor system for detection and analysis of cardiac activity | |
US20220249022A1 (en) | Modular physiologic monitoring systems, kits, and methods | |
AU2015296139B2 (en) | Modular physiologic monitoring systems, kits, and methods | |
US20210244941A1 (en) | Methods and apparatus for a wearable electronic digital therapeutic device | |
CN105142714B (en) | For controlling the apparatus and method trembled | |
US20180200514A1 (en) | Non-invasive nerve stimulation | |
Postolache et al. | Smart clothes for rehabilitation context: technical and technological issues | |
JP7434163B2 (en) | non-invasive nerve stimulation | |
WO2023196805A2 (en) | Wearable electronic for digital healthcare |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190927 |
|
WD01 | Invention patent application deemed withdrawn after publication |